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    Adam Abate, PhD

    TitleAssistant Professor
    SchoolUCSF School of Pharmacy
    DepartmentBioengineering and Therapeutic Sciences
    Address1700 4th Street
    San Francisco CA 94158
    Phone415-476-9819

       Biography 
       Awards and Honors
      Harvard University2000 - 2002Stanley A. Marks Scholar
      NSF2013 - 2018CAREER Award
      NSF, NIMS2013 - 2014US-Japan Young Scientist Exchange Program

       Overview 
       Overview
      Dr. Adam Abate is a physicist who brings a unique research program to the campus. His research employs microfluidics for high-throughput biological applications. He has developed microfluidic methods to create emulsions that consist of droplets of very precise and consistent sizes and to manipulate the processing and contents of individual droplets in different ways. The droplets are used to create micro-compartments, which can be loaded with single cells and other active materials, such as drugs, nutrients, and assay reagents. By chaining together different microdevice components, the droplets can be used as tiny "test tubes" for performing chemical and biological reactions. This allows multiple, independent reactions to take place at the rate of thousands per second, while using minuscule amounts of total reagent. Adam is using this approach for directed evolution, genetic sequencing, and cell sorting.

       Interests
      microfluidics, droplet-based microfluidics, soft-condensed matter physics, granular physics, microparticle synthesis, emulsification, bioengineering, drug encapsulation, high-throughput screening, directed evolution, sequencing

       ORNG Applications 
       Websites
       Featured Videos
       In The News

       Bibliographic 
       Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Lim SW, Abate AR. Ultrahigh-throughput sorting of microfluidic drops with flow cytometry. Lab Chip. 2013 Dec 7; 13(23):4563-72.
        View in: PubMed
      2. Abate AR, Hung T, Sperling RA, Mary P, Rotem A, Agresti JJ, Weiner MA, Weitz DA. DNA sequence analysis with droplet-based microfluidics. Lab Chip. 2013 Nov 12; 13(24):4864-9.
        View in: PubMed
      3. Eastburn DJ, Sciambi A, Abate AR. Ultrahigh-throughput Mammalian single-cell reverse-transcriptase polymerase chain reaction in microfluidic drops. Anal Chem. 2013 Aug 20; 85(16):8016-21.
        View in: PubMed
      4. Eastburn DJ, Sciambi A, Abate AR. Picoinjection enables digital detection of RNA with droplet rt-PCR. PLoS One. 2013; 8(4):e62961.
        View in: PubMed
      5. Thompson CS, Abate AR. Adhesive-based bonding technique for PDMS microfluidic devices. Lab Chip. 2013 Feb 21; 13(4):632-5.
        View in: PubMed
      6. Romero PA, Abate AR. Flow focusing geometry generates droplets through a plug and squeeze mechanism. Lab Chip. 2012 Dec 21; 12(24):5130-2.
        View in: PubMed
      7. Rotem A, Abate AR, Utada AS, Van Steijn V, Weitz DA. Drop formation in non-planar microfluidic devices. Lab Chip. 2012 Nov 7; 12(21):4263-8.
        View in: PubMed
      8. O'Donovan B, Eastburn DJ, Abate AR. Electrode-free picoinjection of microfluidic drops. Lab Chip. 2012 Oct 21; 12(20):4029-32.
        View in: PubMed
      9. Duncanson WJ, Lin T, Abate AR, Seiffert S, Shah RK, Weitz DA. Microfluidic synthesis of advanced microparticles for encapsulation and controlled release. Lab Chip. 2012 Jun 21; 12(12):2135-45.
        View in: PubMed
      10. Abate AR, Mary P, van Steijn V, Weitz DA. Experimental validation of plugging during drop formation in a T-junction. Lab Chip. 2012 Apr 21; 12(8):1516-21.
        View in: PubMed
      11. Romanowsky MB, Abate AR, Rotem A, Holtze C, Weitz DA. High throughput production of single core double emulsions in a parallelized microfluidic device. Lab Chip. 2012 Feb 21; 12(4):802-7.
        View in: PubMed
      12. Liu T, Seiffert S, Thiele J, Abate AR, Weitz DA, Richtering W. Non-coalescence of oppositely charged droplets in pH-sensitive emulsions. Proc Natl Acad Sci U S A. 2012 Jan 10; 109(2):384-9.
        View in: PubMed
      13. Abate AR, Rotem A, Thiele J, Weitz DA. Efficient encapsulation with plug-triggered drop formation. Phys Rev E Stat Nonlin Soft Matter Phys. 2011 Sep; 84(3 Pt 1):031502.
        View in: PubMed
      14. Knowles TP, White DA, Abate AR, Agresti JJ, Cohen SI, Sperling RA, De Genst EJ, Dobson CM, Weitz DA. Observation of spatial propagation of amyloid assembly from single nuclei. Proc Natl Acad Sci U S A. 2011 Sep 6; 108(36):14746-51.
        View in: PubMed
      15. Thiele J, Windbergs M, Abate AR, Trebbin M, Shum HC, Förster S, Weitz DA. Early development drug formulation on a chip: fabrication of nanoparticles using a microfluidic spray dryer. Lab Chip. 2011 Jul 21; 11(14):2362-8.
        View in: PubMed
      16. Mary P, Chen A, Chen I, Abate AR, Weitz DA. On-chip background noise reduction for cell-based assays in droplets. Lab Chip. 2011 Jun 21; 11(12):2066-70.
        View in: PubMed
      17. Abate AR, Weitz DA. Faster multiple emulsification with drop splitting. Lab Chip. 2011 Jun 7; 11(11):1911-5.
        View in: PubMed
      18. Mary P, Abate AR, Agresti JJ, Weitz DA. Controlling droplet incubation using close-packed plug flow. Biomicrofluidics. 2011; 5(2):24101.
        View in: PubMed
      19. Abate AR, Weitz DA. Air-bubble-triggered drop formation in microfluidics. Lab Chip. 2011 May 21; 11(10):1713-6.
        View in: PubMed
      20. Abate AR, Weitz DA. Syringe-vacuum microfluidics: A portable technique to create monodisperse emulsions. Biomicrofluidics. 2011; 5:14107.
        View in: PubMed
      21. Abate AR, Kutsovsky M, Seiffert S, Windbergs M, Pinto LF, Rotem A, Utada AS, Weitz DA. Synthesis of monodisperse microparticles from non-Newtonian polymer solutions with microfluidic devices. Adv Mater. 2011 Apr 19; 23(15):1757-60.
        View in: PubMed
      22. Abate AR, Thiele J, Weitz DA. One-step formation of multiple emulsions in microfluidics. Lab Chip. 2011 Jan 21; 11(2):253-8.
        View in: PubMed
      23. Abate AR, Hung T, Mary P, Agresti JJ, Weitz DA. High-throughput injection with microfluidics using picoinjectors. Proc Natl Acad Sci U S A. 2010 Nov 9; 107(45):19163-6.
        View in: PubMed
      24. Thiele J, Abate AR, Shum HC, Bachtler S, Förster S, Weitz DA. Fabrication of polymersomes using double-emulsion templates in glass-coated stamped microfluidic devices. Small. 2010 Aug 16; 6(16):1723-7.
        View in: PubMed
      25. Abate AR, Thiele J, Weinhart M, Weitz DA. Patterning microfluidic device wettability using flow confinement. Lab Chip. 2010 Jul 21; 10(14):1774-6.
        View in: PubMed
      26. Seiffert S, Thiele J, Abate AR, Weitz DA. Smart microgel capsules from macromolecular precursors. J Am Chem Soc. 2010 May 12; 132(18):6606-9.
        View in: PubMed
      27. Romanowsky MB, Heymann M, Abate AR, Krummel AT, Fraden S, Weitz DA. Functional patterning of PDMS microfluidic devices using integrated chemo-masks. Lab Chip. 2010 Jun 21; 10(12):1521-4.
        View in: PubMed
      28. Agresti JJ, Antipov E, Abate AR, Ahn K, Rowat AC, Baret JC, Marquez M, Klibanov AM, Griffiths AD, Weitz DA. Ultrahigh-throughput screening in drop-based microfluidics for directed evolution. Proc Natl Acad Sci U S A. 2010 Mar 2; 107(9):4004-9.
        View in: PubMed
      29. Schonbrun E, Abate AR, Steinvurzel PE, Weitz DA, Crozier KB. High-throughput fluorescence detection using an integrated zone-plate array. Lab Chip. 2010 Apr 7; 10(7):852-6.
        View in: PubMed
      30. Shum HC, Abate AR, Lee D, Studart AR, Wang B, Chen CH, Thiele J, Shah RK, Krummel A, Weitz DA. Droplet microfluidics for fabrication of non-spherical particles. Macromol Rapid Commun. 2010 Jan 18; 31(2):108-18.
        View in: PubMed
      31. Abate AR, Weitz DA. High-order multiple emulsions formed in poly(dimethylsiloxane) microfluidics. Small. 2009 Sep; 5(18):2030-2.
        View in: PubMed
      32. Abate AR, Poitzsch A, Hwang Y, Lee J, Czerwinska J, Weitz DA. Impact of inlet channel geometry on microfluidic drop formation. Phys Rev E Stat Nonlin Soft Matter Phys. 2009 Aug; 80(2 Pt 2):026310.
        View in: PubMed
      33. Tang SK, Li Z, Abate AR, Agresti JJ, Weitz DA, Psaltis D, Whitesides GM. A multi-color fast-switching microfluidic droplet dye laser. Lab Chip. 2009 Oct 7; 9(19):2767-71.
        View in: PubMed
      34. Abate AR, Chen CH, Agresti JJ, Weitz DA. Beating Poisson encapsulation statistics using close-packed ordering. Lab Chip. 2009 Sep 21; 9(18):2628-31.
        View in: PubMed
      35. Franke T, Abate AR, Weitz DA, Wixforth A. Surface acoustic wave (SAW) directed droplet flow in microfluidics for PDMS devices. Lab Chip. 2009 Sep 21; 9(18):2625-7.
        View in: PubMed
      36. Chen CH, Shah RK, Abate AR, Weitz DA. Janus particles templated from double emulsion droplets generated using microfluidics. Langmuir. 2009 Apr 21; 25(8):4320-3.
        View in: PubMed
      37. Abate AR, Durian DJ. Effective temperatures and activated dynamics for a two-dimensional air-driven granular system on two approaches to jamming. Phys Rev Lett. 2008 Dec 12; 101(24):245701.
        View in: PubMed
      38. Abate AR, Krummel AT, Lee D, Marquez M, Holtze C, Weitz DA. Photoreactive coating for high-contrast spatial patterning of microfluidic device wettability. Lab Chip. 2008 Dec; 8(12):2157-60.
        View in: PubMed
      39. Abate AR, Lee D, Do T, Holtze C, Weitz DA. Glass coating for PDMS microfluidic channels by sol-gel methods. Lab Chip. 2008 Apr; 8(4):516-8.
        View in: PubMed
      40. Abate AR, Katsuragi H, Durian DJ. Avalanche statistics and time-resolved grain dynamics for a driven heap. Phys Rev E Stat Nonlin Soft Matter Phys. 2007 Dec; 76(6 Pt 1):061301.
        View in: PubMed
      41. Abate AR, Durian DJ. Spatially heterogeneous dynamics in a granular system near jamming. Chaos. 2007 Dec; 17(4):041107.
        View in: PubMed
      42. Abate AR, Durian DJ. Topological persistence and dynamical heterogeneities near jamming. Phys Rev E Stat Nonlin Soft Matter Phys. 2007 Aug; 76(2 Pt 1):021306.
        View in: PubMed
      43. Abate AR, Durian DJ. Approach to jamming in an air-fluidized granular bed. Phys Rev E Stat Nonlin Soft Matter Phys. 2006 Sep; 74(3 Pt 1):031308.
        View in: PubMed
      44. Abate AR, Durian DJ. Partition of energy for air-fluidized grains. Phys Rev E Stat Nonlin Soft Matter Phys. 2005 Sep; 72(3 Pt 1):031305.
        View in: PubMed
      45. Ambroso MA, Santore CR, Abate AR, Durian DJ. Penetration depth for shallow impact cratering. Phys Rev E Stat Nonlin Soft Matter Phys. 2005 May; 71(5 Pt 1):051305.
        View in: PubMed
      46. Ojha RP, Abate AR, Durian DJ. Statistical characterization of the forces on spheres in an upflow of air. Phys Rev E Stat Nonlin Soft Matter Phys. 2005 Jan; 71(1 Pt 2):016313.
        View in: PubMed
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