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    Robert Fletterick, PhD

    TitleProfessor
    SchoolUCSF School of Medicine
    DepartmentBiochemistry and Biophysics
    Address600 16th Street
    San Francisco CA 94158
    Phone415-476-5080

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       Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Benod C, Villagomez R, Filgueira CS, Hwang PK, Leonard PG, Poncet-Montange G, Rajagopalan S, Fletterick RJ, Gustafsson JÅ, Webb P. The Human Orphan Nuclear Receptor Tailless (TLX, NR2E1) Is Druggable. PLoS One. 2014; 9(6):e99440.
        View in: PubMed
      2. Bhattacharya S, Lou X, Hwang P, Rajashankar KR, Wang X, Gustafsson JÅ, Fletterick RJ, Jacobson RH, Webb P. Structural and functional insight into TAF1-TAF7, a subcomplex of transcription factor II D. Proc Natl Acad Sci U S A. 2014 Jun 24; 111(25):9103-8.
        View in: PubMed
      3. Larsen CC, Dumitrescu A, Guerra-Argüero LM, Gállego-Suárez C, Vazquez-Mellado A, Vinogradova M, Fletterick R, Refetoff S, Weiss RE. Incidental Identification of a Thyroid Hormone Receptor Beta (THRB) Gene Variant in a Family with Autoimmune Thyroid Disease. Thyroid. 2013 Dec; 23(12):1638-43.
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      4. Benod C, Carlsson J, Uthayaruban R, Hwang P, Irwin JJ, Doak AK, Shoichet BK, Sablin EP, Fletterick RJ. Structure-based discovery of antagonists of nuclear receptor LRH-1. J Biol Chem. 2013 Jul 5; 288(27):19830-44.
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      5. Kumar A, Möcklinghoff S, Yumoto F, Jaroszewski L, Farr CL, Grzechnik A, Nguyen P, Weichenberger CX, Chiu HJ, Klock HE, Elsliger MA, Deacon AM, Godzik A, Lesley SA, Conklin BR, Fletterick RJ, Wilson IA. Structure of a novel winged-helix like domain from human NFRKB protein. PLoS One. 2012; 7(9):e43761.
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      6. Yumoto F, Nguyen P, Sablin EP, Baxter JD, Webb P, Fletterick RJ. Structural basis of coactivation of liver receptor homolog-1 by ß-catenin. Proc Natl Acad Sci U S A. 2012 Jan 3; 109(1):143-8.
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      7. Benod C, Vinogradova MV, Jouravel N, Kim GE, Fletterick RJ, Sablin EP. Nuclear receptor liver receptor homologue 1 (LRH-1) regulates pancreatic cancer cell growth and proliferation. Proc Natl Acad Sci U S A. 2011 Oct 11; 108(41):16927-31.
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      8. Buzón V, Carbó LR, Estruch SB, Fletterick RJ, Estébanez-Perpiñá E. A conserved surface on the ligand binding domain of nuclear receptors for allosteric control. Mol Cell Endocrinol. 2012 Jan 30; 348(2):394-402.
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      9. De Leon JT, Iwai A, Feau C, Garcia Y, Balsiger HA, Storer CL, Suro RM, Garza KM, Lee S, Kim YS, Chen Y, Ning YM, Riggs DL, Fletterick RJ, Guy RK, Trepel JB, Neckers LM, Cox MB. Targeting the regulation of androgen receptor signaling by the heat shock protein 90 cochaperone FKBP52 in prostate cancer cells. Proc Natl Acad Sci U S A. 2011 Jul 19; 108(29):11878-83.
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      10. Hjelm RP, Stone DB, Fletterick RJ, Mendelson RA. Decoration of microtubules in solution by the kinesin-14, Ncd. Acta Crystallogr D Biol Crystallogr. 2010 Nov; 66(Pt 11):1218-23.
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      11. Wilbur JD, Hwang PK, Ybe JA, Lane M, Sellers BD, Jacobson MP, Fletterick RJ, Brodsky FM. Conformation switching of clathrin light chain regulates clathrin lattice assembly. Dev Cell. 2010 May 18; 18(5):841-8.
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      12. Pfaff SJ, Fletterick RJ. Hormone binding and co-regulator binding to the glucocorticoid receptor are allosterically coupled. J Biol Chem. 2010 May 14; 285(20):15256-67.
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      13. Wilbur JD, Hwang PK, Brodsky FM, Fletterick RJ. Accommodation of structural rearrangements in the huntingtin-interacting protein 1 coiled-coil domain. Acta Crystallogr D Biol Crystallogr. 2010 Mar; 66(Pt 3):314-8.
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      14. Vinogradova MV, Malanina GG, Reddy AS, Fletterick RJ. Structure of the complex of a mitotic kinesin with its calcium binding regulator. Proc Natl Acad Sci U S A. 2009 May 19; 106(20):8175-9.
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      15. Jouravel N, Sablin E, Togashi M, Baxter JD, Webb P, Fletterick RJ. Molecular basis for dimer formation of TRbeta variant D355R. Proteins. 2009 Apr; 75(1):111-7.
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      16. Sablin EP, Woods A, Krylova IN, Hwang P, Ingraham HA, Fletterick RJ. The structure of corepressor Dax-1 bound to its target nuclear receptor LRH-1. Proc Natl Acad Sci U S A. 2008 Nov 25; 105(47):18390-5.
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      17. Sablin EP, Blind RD, Krylova IN, Ingraham JG, Cai F, Williams JD, Fletterick RJ, Ingraham HA. Structure of SF-1 bound by different phospholipids: evidence for regulatory ligands. Mol Endocrinol. 2009 Jan; 23(1):25-34.
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      18. Cruz LA, Estébanez-Perpiñá E, Pfaff S, Borngraeber S, Bao N, Blethrow J, Fletterick RJ, England PM. 6-Azido-7-nitro-1,4-dihydroquinoxaline-2,3-dione (ANQX) forms an irreversible bond to the active site of the GluR2 AMPA receptor. J Med Chem. 2008 Sep 25; 51(18):5856-60.
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      19. Wilbur JD, Chen CY, Manalo V, Hwang PK, Fletterick RJ, Brodsky FM. Actin binding by Hip1 (huntingtin-interacting protein 1) and Hip1R (Hip1-related protein) is regulated by clathrin light chain. J Biol Chem. 2008 Nov 21; 283(47):32870-9.
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      20. Vinogradova MV, Malanina GG, Reddy VS, Reddy AS, Fletterick RJ. Structural dynamics of the microtubule binding and regulatory elements in the kinesin-like calmodulin binding protein. J Struct Biol. 2008 Jul; 163(1):76-83.
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      21. Jouravel N, Sablin E, Arnold LA, Guy RK, Fletterick RJ. Interaction between the androgen receptor and a segment of its corepressor SHP. Acta Crystallogr D Biol Crystallogr. 2007 Nov; 63(Pt 11):1198-200.
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      22. Arnold LA, Kosinski A, Estébanez-Perpiñá E, Fletterick RJ, Guy RK. Inhibitors of the interaction of a thyroid hormone receptor and coactivators: preliminary structure-activity relationships. J Med Chem. 2007 Nov 1; 50(22):5269-80.
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      23. Estébanez-Perpiñá E, Arnold LA, Arnold AA, Nguyen P, Rodrigues ED, Mar E, Bateman R, Pallai P, Shokat KM, Baxter JD, Guy RK, Webb P, Fletterick RJ. A surface on the androgen receptor that allosterically regulates coactivator binding. Proc Natl Acad Sci U S A. 2007 Oct 9; 104(41):16074-9.
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      24. Estébanez-Perpiñá E, Jouravel N, Fletterick RJ. Perspectives on designs of antiandrogens for prostate cancer. Expert Opin Drug Discov. 2007 Oct; 2(10):1341-55.
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      25. Estébanez-Perpiñá E, Arnold LA, Jouravel N, Togashi M, Blethrow J, Mar E, Nguyen P, Phillips KJ, Baxter JD, Webb P, Guy RK, Fletterick RJ. Structural insight into the mode of action of a direct inhibitor of coregulator binding to the thyroid hormone receptor. Mol Endocrinol. 2007 Dec; 21(12):2919-28.
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      26. Wang SX, Pandey KC, Scharfstein J, Whisstock J, Huang RK, Jacobelli J, Fletterick RJ, Rosenthal PJ, Abrahamson M, Brinen LS, Rossi A, Sali A, McKerrow JH. The structure of chagasin in complex with a cysteine protease clarifies the binding mode and evolution of an inhibitor family. Structure. 2007 May; 15(5):535-43.
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      27. Vinogradova MV, Stone DB, Malanina GG, Mendelson RA, Fletterick RJ. Ca ion and the troponin switch. Adv Exp Med Biol. 2007; 592:47-57.
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      28. Wang SX, Pandey KC, Somoza JR, Sijwali PS, Kortemme T, Brinen LS, Fletterick RJ, Rosenthal PJ, McKerrow JH. Structural basis for unique mechanisms of folding and hemoglobin binding by a malarial protease. Proc Natl Acad Sci U S A. 2006 Aug 1; 103(31):11503-8.
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      29. Luginbühl B, Kanyo Z, Jones RM, Fletterick RJ, Prusiner SB, Cohen FE, Williamson RA, Burton DR, Plückthun A. Directed evolution of an anti-prion protein scFv fragment to an affinity of 1 pM and its structural interpretation. J Mol Biol. 2006 Oct 13; 363(1):75-97.
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      30. Arnold LA, Estébanez-Perpiñá E, Togashi M, Shelat A, Ocasio CA, McReynolds AC, Nguyen P, Baxter JD, Fletterick RJ, Webb P, Guy RK. A high-throughput screening method to identify small molecule inhibitors of thyroid hormone receptor coactivator binding. Sci STKE. 2006 Jun 27; 2006(341):pl3.
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      31. Pirani A, Vinogradova MV, Curmi PM, King WA, Fletterick RJ, Craig R, Tobacman LS, Xu C, Hatch V, Lehman W. An atomic model of the thin filament in the relaxed and Ca2+-activated states. J Mol Biol. 2006 Mar 31; 357(3):707-17.
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      32. Blumenschein TM, Stone DB, Fletterick RJ, Mendelson RA, Sykes BD. Dynamics of the C-terminal region of TnI in the troponin complex in solution. Biophys J. 2006 Apr 1; 90(7):2436-44.
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      33. Fletterick RJ. Molecular modelling of the androgen receptor axis: rational basis for androgen receptor intervention in androgen-independent prostate cancer. BJU Int. 2005 Dec; 96 Suppl 2:2-9.
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      34. Arnold LA, Estébanez-Perpiñá E, Togashi M, Jouravel N, Shelat A, McReynolds AC, Mar E, Nguyen P, Baxter JD, Fletterick RJ, Webb P, Guy RK. Discovery of small molecule inhibitors of the interaction of the thyroid hormone receptor with transcriptional coregulators. J Biol Chem. 2005 Dec 30; 280(52):43048-55.
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      35. Togashi M, Nguyen P, Fletterick R, Baxter JD, Webb P. Rearrangements in thyroid hormone receptor charge clusters that stabilize bound 3,5',5-triiodo-L-thyronine and inhibit homodimer formation. J Biol Chem. 2005 Jul 8; 280(27):25665-73.
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      36. Blumenschein TM, Stone DB, Fletterick RJ, Mendelson RA, Sykes BD. Calcium-dependent changes in the flexibility of the regulatory domain of troponin C in the troponin complex. J Biol Chem. 2005 Jun 10; 280(23):21924-32.
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      37. Vinogradova MV, Stone DB, Malanina GG, Karatzaferi C, Cooke R, Mendelson RA, Fletterick RJ. Ca(2+)-regulated structural changes in troponin. Proc Natl Acad Sci U S A. 2005 Apr 5; 102(14):5038-43.
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      38. Togashi M, Borngraeber S, Sandler B, Fletterick RJ, Webb P, Baxter JD. Conformational adaptation of nuclear receptor ligand binding domains to agonists: potential for novel approaches to ligand design. J Steroid Biochem Mol Biol. 2005 Feb; 93(2-5):127-37.
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      39. Krylova IN, Sablin EP, Moore J, Xu RX, Waitt GM, MacKay JA, Juzumiene D, Bynum JM, Madauss K, Montana V, Lebedeva L, Suzawa M, Williams JD, Williams SP, Guy RK, Thornton JW, Fletterick RJ, Willson TM, Ingraham HA. Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1. Cell. 2005 Feb 11; 120(3):343-55.
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      40. Estébanez-Perpiñá E, Moore JM, Mar E, Delgado-Rodrigues E, Nguyen P, Baxter JD, Buehrer BM, Webb P, Fletterick RJ, Guy RK. The molecular mechanisms of coactivator utilization in ligand-dependent transactivation by the androgen receptor. J Biol Chem. 2005 Mar 4; 280(9):8060-8.
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      41. Sandler B, Webb P, Apriletti JW, Huber BR, Togashi M, Cunha Lima ST, Juric S, Nilsson S, Wagner R, Fletterick RJ, Baxter JD. Thyroxine-thyroid hormone receptor interactions. J Biol Chem. 2004 Dec 31; 279(53):55801-8.
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      42. Hur E, Pfaff SJ, Payne ES, Grøn H, Buehrer BM, Fletterick RJ. Recognition and accommodation at the androgen receptor coactivator binding interface. PLoS Biol. 2004 Sep; 2(9):E274.
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      43. Ruggles SW, Fletterick RJ, Craik CS. Characterization of structural determinants of granzyme B reveals potent mediators of extended substrate specificity. J Biol Chem. 2004 Jul 16; 279(29):30751-9.
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      44. Shipley K, Hekmat-Nejad M, Turner J, Moores C, Anderson R, Milligan R, Sakowicz R, Fletterick R. Structure of a kinesin microtubule depolymerization machine. EMBO J. 2004 Apr 7; 23(7):1422-32.
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      45. Vinogradova MV, Reddy VS, Reddy AS, Sablin EP, Fletterick RJ. Crystal structure of kinesin regulated by Ca(2+)-calmodulin. J Biol Chem. 2004 May 28; 279(22):23504-9.
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      46. Sablin EP, Fletterick RJ. Coordination between motor domains in processive kinesins. J Biol Chem. 2004 Apr 16; 279(16):15707-10.
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      47. Borngraeber S, Budny MJ, Chiellini G, Cunha-Lima ST, Togashi M, Webb P, Baxter JD, Scanlan TS, Fletterick RJ. Ligand selectivity by seeking hydrophobicity in thyroid hormone receptor. Proc Natl Acad Sci U S A. 2003 Dec 23; 100(26):15358-63.
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      48. Wang SX, Hur E, Sousa CA, Brinen L, Slivka EJ, Fletterick RJ. The extended interactions and Gla domain of blood coagulation factor Xa. Biochemistry. 2003 Jul 8; 42(26):7959-66.
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      49. Bell JK, Goetz DH, Mahrus S, Harris JL, Fletterick RJ, Craik CS. The oligomeric structure of human granzyme A is a determinant of its extended substrate specificity. Nat Struct Biol. 2003 Jul; 10(7):527-34.
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      50. Sablin EP, Krylova IN, Fletterick RJ, Ingraham HA. Structural basis for ligand-independent activation of the orphan nuclear receptor LRH-1. Mol Cell. 2003 Jun; 11(6):1575-85.
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      51. Huber BR, Sandler B, West BL, Cunha Lima ST, Nguyen HT, Apriletti JW, Baxter JD, Fletterick RJ. Two resistance to thyroid hormone mutants with impaired hormone binding. Mol Endocrinol. 2003 Apr; 17(4):643-52.
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      52. Huber BR, Desclozeaux M, West BL, Cunha-Lima ST, Nguyen HT, Baxter JD, Ingraham HA, Fletterick RJ. Thyroid hormone receptor-beta mutations conferring hormone resistance and reduced corepressor release exhibit decreased stability in the N-terminal ligand-binding domain. Mol Endocrinol. 2003 Jan; 17(1):107-16.
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      53. Webb P, Nguyen NH, Chiellini G, Yoshihara HA, Cunha Lima ST, Apriletti JW, Ribeiro RC, Marimuthu A, West BL, Goede P, Mellstrom K, Nilsson S, Kushner PJ, Fletterick RJ, Scanlan TS, Baxter JD. Design of thyroid hormone receptor antagonists from first principles. J Steroid Biochem Mol Biol. 2002 Dec; 83(1-5):59-73.
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      54. Sindelar CV, Budny MJ, Rice S, Naber N, Fletterick R, Cooke R. Two conformations in the human kinesin power stroke defined by X-ray crystallography and EPR spectroscopy. Nat Struct Biol. 2002 Nov; 9(11):844-8.
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      55. Desclozeaux M, Krylova IN, Horn F, Fletterick RJ, Ingraham HA. Phosphorylation and intramolecular stabilization of the ligand binding domain in the nuclear receptor steroidogenic factor 1. Mol Cell Biol. 2002 Oct; 22(20):7193-203.
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      56. Dawson JF, Sablin EP, Spudich JA, Fletterick RJ. Structure of an F-actin trimer disrupted by gelsolin and implications for the mechanism of severing. J Biol Chem. 2003 Jan 10; 278(2):1229-38.
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      57. Sablin EP, Dawson JF, VanLoock MS, Spudich JA, Egelman EH, Fletterick RJ. How does ATP hydrolysis control actin's associations? Proc Natl Acad Sci U S A. 2002 Aug 20; 99(17):10945-7.
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      58. Ekstrom JL, Pauly TA, Carty MD, Soeller WC, Culp J, Danley DE, Hoover DJ, Treadway JL, Gibbs EM, Fletterick RJ, Day YS, Myszka DG, Rath VL. Structure-activity analysis of the purine binding site of human liver glycogen phosphorylase. Chem Biol. 2002 Aug; 9(8):915-24.
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      59. Walther M, Anton M, Wiedmann M, Fletterick R, Kuhn H. The N-terminal domain of the reticulocyte-type 15-lipoxygenase is not essential for enzymatic activity but contains determinants for membrane binding. J Biol Chem. 2002 Jul 26; 277(30):27360-6.
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      60. Laboissière MC, Young MM, Pinho RG, Todd S, Fletterick RJ, Kuntz I, Craik CS. Computer-assisted mutagenesis of ecotin to engineer its secondary binding site for urokinase inhibition. J Biol Chem. 2002 Jul 19; 277(29):26623-31.
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      61. Baxter JD, Goede P, Apriletti JW, West BL, Feng W, Mellstrom K, Fletterick RJ, Wagner RL, Kushner PJ, Ribeiro RC, Webb P, Scanlan TS, Nilsson S. Structure-based design and synthesis of a thyroid hormone receptor (TR) antagonist. Endocrinology. 2002 Feb; 143(2):517-24.
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      62. Marimuthu A, Feng W, Tagami T, Nguyen H, Jameson JL, Fletterick RJ, Baxter JD, West BL. TR surfaces and conformations required to bind nuclear receptor corepressor. Mol Endocrinol. 2002 Feb; 16(2):271-86.
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      63. Sablin EP, Fletterick RJ. Nucleotide switches in molecular motors: structural analysis of kinesins and myosins. Curr Opin Struct Biol. 2001 Dec; 11(6):716-24.
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      64. Martín MA, Rubio JC, Buchbinder J, Fernández-Hojas R, del Hoyo P, Teijeira S, Gámez J, Navarro C, Fernández JM, Cabello A, Campos Y, Cervera C, Culebras JM, Andreu AL, Fletterick R, Arenas J. Molecular heterogeneity of myophosphorylase deficiency (McArdle's disease): a genotype-phenotype correlation study. Ann Neurol. 2001 Nov; 50(5):574-81.
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      65. Wang SX, Esmon CT, Fletterick RJ. Crystal structure of thrombin-ecotin reveals conformational changes and extended interactions. Biochemistry. 2001 Aug 28; 40(34):10038-46.
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      66. Kikkawa M, Sablin EP, Okada Y, Yajima H, Fletterick RJ, Hirokawa N. Switch-based mechanism of kinesin motors. Nature. 2001 May 24; 411(6836):439-45.
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      67. Eggers CT, Wang SX, Fletterick RJ, Craik CS. The role of ecotin dimerization in protease inhibition. J Mol Biol. 2001 May 18; 308(5):975-91.
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      68. Turner J, Anderson R, Guo J, Beraud C, Fletterick R, Sakowicz R. Crystal structure of the mitotic spindle kinesin Eg5 reveals a novel conformation of the neck-linker. J Biol Chem. 2001 Jul 6; 276(27):25496-502.
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      69. Wagner RL, Huber BR, Shiau AK, Kelly A, Cunha Lima ST, Scanlan TS, Apriletti JW, Baxter JD, West BL, Fletterick RJ. Hormone selectivity in thyroid hormone receptors. Mol Endocrinol. 2001 Mar; 15(3):398-410.
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      70. Ribeiro RC, Feng W, Wagner RL, Costa CH, Pereira AC, Apriletti JW, Fletterick RJ, Baxter JD. Definition of the surface in the thyroid hormone receptor ligand binding domain for association as homodimers and heterodimers with retinoid X receptor. J Biol Chem. 2001 May 4; 276(18):14987-95.
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      71. Buchbinder JL, Rath VL, Fletterick RJ. Structural relationships among regulated and unregulated phosphorylases. Annu Rev Biophys Biomol Struct. 2001; 30:191-209.
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      72. Baxter JD, Dillmann WH, West BL, Huber R, Furlow JD, Fletterick RJ, Webb P, Apriletti JW, Scanlan TS. Selective modulation of thyroid hormone receptor action. J Steroid Biochem Mol Biol. 2001 Jan-Mar; 76(1-5):31-42.
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      73. Kapila Y, Doan D, Tafolla E, Fletterick R. Three-dimensional structural analysis of fibronectin heparin-binding domain mutations. J Cell Biochem Suppl. 2001; Suppl 36:156-61.
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      74. Waugh SM, Harris JL, Fletterick R, Craik CS. The structure of the pro-apoptotic protease granzyme B reveals the molecular determinants of its specificity. Nat Struct Biol. 2000 Sep; 7(9):762-5.
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      75. Brinen LS, Hansell E, Cheng J, Roush WR, McKerrow JH, Fletterick RJ. A target within the target: probing cruzain's P1' site to define structural determinants for the Chagas' disease protease. Structure. 2000 Aug 15; 8(8):831-40.
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      76. Gillmor SA, Takeuchi T, Yang SQ, Craik CS, Fletterick RJ. Compromise and accommodation in ecotin, a dimeric macromolecular inhibitor of serine proteases. J Mol Biol. 2000 Jun 16; 299(4):993-1003.
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      77. Vale RD, Case R, Sablin E, Hart C, Fletterick R. Searching for kinesin's mechanical amplifier. Philos Trans R Soc Lond B Biol Sci. 2000 Apr 29; 355(1396):449-57.
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      78. Borngräber S, Browner M, Gillmor S, Gerth C, Anton M, Fletterick R, Kühn H. Shape and specificity in mammalian 15-lipoxygenase active site. The functional interplay of sequence determinants for the reaction specificity. J Biol Chem. 1999 Dec 24; 274(52):37345-50.
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      79. Han Y, Sablin EP, Nogales E, Fletterick RJ, Downing KH. Visualizing a new binding site of ncd-motor domain on tubulin. J Struct Biol. 1999 Dec 1; 128(1):26-33.
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      80. Kanyo ZF, Pan KM, Williamson RA, Burton DR, Prusiner SB, Fletterick RJ, Cohen FE. Antibody binding defines a structure for an epitope that participates in the PrPC-->PrPSc conformational change. J Mol Biol. 1999 Nov 5; 293(4):855-63.
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      81. Norman AW, Adams D, Collins ED, Okamura WH, Fletterick RJ. Three-dimensional model of the ligand binding domain of the nuclear receptor for 1alpha,25-dihydroxy-vitamin D(3). J Cell Biochem. 1999 Sep 1; 74(3):323-33.
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      82. Ybe JA, Brodsky FM, Hofmann K, Lin K, Liu SH, Chen L, Earnest TN, Fletterick RJ, Hwang PK. Clathrin self-assembly is mediated by a tandemly repeated superhelix. Nature. 1999 May 27; 399(6734):371-5.
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      83. Weatherman RV, Fletterick RJ, Scanlan TS. Nuclear-receptor ligands and ligand-binding domains. Annu Rev Biochem. 1999; 68:559-81.
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      84. Butte MJ, Hwang PK, Mobley WC, Fletterick RJ. Crystal structure of neurotrophin-3 homodimer shows distinct regions are used to bind its receptors. Biochemistry. 1998 Dec 1; 37(48):16846-52.
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      85. Darimont BD, Wagner RL, Apriletti JW, Stallcup MR, Kushner PJ, Baxter JD, Fletterick RJ, Yamamoto KR. Structure and specificity of nuclear receptor-coactivator interactions. Genes Dev. 1998 Nov 1; 12(21):3343-56.
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      86. Apriletti JW, Ribeiro RC, Wagner RL, Feng W, Webb P, Kushner PJ, West BL, Nilsson S, Scanlan TS, Fletterick RJ, Baxter JD. Molecular and structural biology of thyroid hormone receptors. Clin Exp Pharmacol Physiol Suppl. 1998 Nov; 25:S2-11.
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      87. Kull FJ, Vale RD, Fletterick RJ. The case for a common ancestor: kinesin and myosin motor proteins and G proteins. J Muscle Res Cell Motil. 1998 Nov; 19(8):877-86.
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      88. Focia PJ, Craig SP, Nieves-Alicea R, Fletterick RJ, Eakin AE. A 1.4 A crystal structure for the hypoxanthine phosphoribosyltransferase of Trypanosoma cruzi. Biochemistry. 1998 Oct 27; 37(43):15066-75.
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      89. Sablin EP, Case RB, Dai SC, Hart CL, Ruby A, Vale RD, Fletterick RJ. Direction determination in the minus-end-directed kinesin motor ncd. Nature. 1998 Oct 22; 395(6704):813-6.
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      90. Buchbinder JL, Stephenson RC, Scanlan TS, Fletterick RJ. A comparison of the crystallographic structures of two catalytic antibodies with esterase activity. J Mol Biol. 1998 Oct 9; 282(5):1033-41.
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      91. Collingwood TN, Wagner R, Matthews CH, Clifton-Bligh RJ, Gurnell M, Rajanayagam O, Agostini M, Fletterick RJ, Beck-Peccoz P, Reinhardt W, Binder G, Ranke MB, Hermus A, Hesch RD, Lazarus J, Newrick P, Parfitt V, Raggatt P, de Zegher F, Chatterjee VK. A role for helix 3 of the TRbeta ligand-binding domain in coactivator recruitment identified by characterization of a third cluster of mutations in resistance to thyroid hormone. EMBO J. 1998 Aug 17; 17(16):4760-70.
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      92. Kull FJ, Fletterick RJ. Is the tubulin/FtsZ fold related to the G-protein fold? Trends Cell Biol. 1998 Aug; 8(8):306-7.
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      93. Yang SQ, Wang CI, Gillmor SA, Fletterick RJ, Craik CS. Ecotin: a serine protease inhibitor with two distinct and interacting binding sites. J Mol Biol. 1998 Jun 19; 279(4):945-57.
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      94. Feng W, Ribeiro RC, Wagner RL, Nguyen H, Apriletti JW, Fletterick RJ, Baxter JD, Kushner PJ, West BL. Hormone-dependent coactivator binding to a hydrophobic cleft on nuclear receptors. Science. 1998 Jun 12; 280(5370):1747-9.
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      95. Clifton-Bligh RJ, de Zegher F, Wagner RL, Collingwood TN, Francois I, Van Helvoirt M, Fletterick RJ, Chatterjee VK. A novel TR beta mutation (R383H) in resistance to thyroid hormone syndrome predominantly impairs corepressor release and negative transcriptional regulation. Mol Endocrinol. 1998 May; 12(5):609-21.
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      96. Somoza JR, Skillman AG, Munagala NR, Oshiro CM, Knegtel RM, Mpoke S, Fletterick RJ, Kuntz ID, Wang CC. Rational design of novel antimicrobials: blocking purine salvage in a parasitic protozoan. Biochemistry. 1998 Apr 21; 37(16):5344-8.
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      97. Buchbinder JL, Stephenson RC, Dresser MJ, Pitera JW, Scanlan TS, Fletterick RJ. Biochemical characterization and crystallographic structure of an Escherichia coli protein from the phosphotriesterase gene family. Biochemistry. 1998 Apr 14; 37(15):5096-106.
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      216. Craik CS, Largman C, Fletcher T, Roczniak S, Barr PJ, Fletterick R, Rutter WJ. Redesigning trypsin: alteration of substrate specificity. Science. 1985 Apr 19; 228(4697):291-7.
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      217. Fletterick RJ, Sygusch J. Measuring X-ray diffraction data from large proteins with X-ray diffractometry. Methods Enzymol. 1985; 114:386-97.
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      218. Hwang P, Stern M, Fletterick RJ. Purification and crystallization of bovine liver phosphorylase. Biochim Biophys Acta. 1984 Dec 7; 791(2):252-8.
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      219. Lebo RV, Gorin F, Fletterick RJ, Kao FT, Cheung MC, Bruce BD, Kan YW. High-resolution chromosome sorting and DNA spot-blot analysis assign McArdle's syndrome to chromosome 11. Science. 1984 Jul 6; 225(4657):57-9.
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      220. Thaller C, Alberts B, Goldsmith E, Sprang S, Fletterick R. Crystallization of the gene 45 protein from the DNA replication fork of bacteriophage T4. J Biol Chem. 1984 Feb 25; 259(4):2568-9.
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      221. Cohen FE, Abarbanel RM, Kuntz ID, Fletterick RJ. Secondary structure assignment for alpha/beta proteins by a combinatorial approach. Biochemistry. 1983 Oct 11; 22(21):4894-904.
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      222. Madsen NB, Shechosky S, Fletterick RJ. Site-site interactions in glycogen phosphorylase b probed by ligands specific for each site. Biochemistry. 1983 Sep 13; 22(19):4460-5.
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      223. Craik CS, Rutter WJ, Fletterick R. Splice junctions: association with variation in protein structure. Science. 1983 Jun 10; 220(4602):1125-9.
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      224. Sprang SR, Goldsmith EJ, Fletterick RJ, Withers SG, Madsen NB. Catalytic site of glycogen phosphorylase: structure of the T state and specificity for alpha-D-glucose. Biochemistry. 1982 Oct 12; 21(21):5364-71.
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      225. Withers SG, Madsen NB, Sprang SR, Fletterick RJ. Catalytic site of glycogen phosphorylase: structural changes during activation and mechanistic implications. Biochemistry. 1982 Oct 12; 21(21):5372-82.
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      226. Craik CS, Sprang S, Fletterick R, Rutter WJ. Intron-exon splice junctions map at protein surfaces. Nature. 1982 Sep 9; 299(5879):180-2.
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      227. Sprang S, Fletterick R, Stern M, Yang D, Madsen N, Sturtevant J. Analysis of an allosteric binding site: the nucleoside inhibitor site of phosphorylase alpha. Biochemistry. 1982 Apr 27; 21(9):2036-48.
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      228. Goldsmith E, Sprang S, Fletterick R. Structure of maltoheptaose by difference Fourier methods and a model for glycogen. J Mol Biol. 1982 Apr 5; 156(2):411-27.
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      229. Kasvinsky PJ, Fletterick RJ, Madsen NB. Regulation of the dephosphorylation of glycogen phosphorylase a and synthase b by glucose and caffeine in isolated hepatocytes. Can J Biochem. 1981 Jun; 59(6):387-95.
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      230. Sprang S, Fletterick RJ. Subunit interactions and the allosteric response in phosphorylase. Biophys J. 1980 Oct; 32(1):175-92.
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      231. Matela RJ, Fletterick RJ. Computer simulation of cellular self-sorting: a topological exchange model. J Theor Biol. 1980 Jun 21; 84(4):673-90.
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      232. Fletterick RJ, Madsen NB. The structures and related functions of phosphorylase a. Annu Rev Biochem. 1980; 49:31-61.
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      233. Sprang S, Yang D, Fletterick RJ. Solvent accessibility properties of complex proteins. Nature. 1979 Jul 26; 280(5720):333-5.
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      234. Sprang S, Fletterick RJ. The structure of glycogen phosphorylase alpha at 2.5 A resolution. J Mol Biol. 1979 Jul 5; 131(3):523-51.
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      235. Fletterick RJ, Sprang S, Madsen NB. Analysis of the surface topography of glycogen phosphorylase a: implications for metabolic interconversion and regulatory mechanisms. Can J Biochem. 1979 Jun; 57(6):789-97.
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      236. Withers SG, Yang DS, Madsen NB, Fletterick RJ. A systematic approach to isomorphous replacement using a series of simple charged mercurials. Biochem Biophys Res Commun. 1979 Feb 28; 86(4):1044-50.
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      237. Matela RJ, Fletterick RJ. A topological exchange model for cell self-sorting. J Theor Biol. 1979 Feb 21; 76(4):403-14.
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      238. Sprang S, Fletterick RJ. Crystallographic analysis of phosphorylase alpha at 2.5 A resolution, a comment on the chemical sequence. Biochemistry. 1978 Dec 26; 17(26):5693-4.
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      239. Madsen NB. Allosteric transitions of phosphorylase a and the regulation of glycogen metabolism. J Biol Chem. 1978 Dec 25; 253(24):9097-101.
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      240. Kasvinsky PJ, Shechosky S, Fletterick RJ. Synergistic regulation of phosphorylase a by glucose and caffeine. J Biol Chem. 1978 Dec 25; 253(24):9102-6.
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      241. Kasvinsky PJ, Madsen NB, Sygusch J, Fletterick RJ. The regulation of glycogen phosphorylase alpha by nucleotide derivatives. Kinetic and x-ray crystallographic studies. J Biol Chem. 1978 May 10; 253(9):3343-51.
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      242. Kasvinsky PJ, Madsen NB, Fletterick RJ, Sygusch J. X-ray crystallographic and kinetic studies of oligosaccharide binding to phosphorylase. J Biol Chem. 1978 Feb 25; 253(4):1290-6.
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      243. Sygusch J, Madsen NB, Kasvinsky PJ, Fletterick RJ. Location of pyridoxal phosphate in glycogen phosphorylase a. Proc Natl Acad Sci U S A. 1977 Nov; 74(11):4757-61.
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      244. Steitz TA, Anderson WF, Fletterick RJ, Anderson CM. High resolution crystal structures of yeast hexokinase complexes with substrates, activators, and inhibitors. Evidence for an allosteric control site. J Biol Chem. 1977 Jul 10; 252(13):4494-500.
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      245. Li EC, Fletterick RJ, Sygusch J, Madsen NB. An essential arginine residue in the active-site pocket of glycogen phosporylase. Can J Biochem. 1977 Apr; 55(4):465-73.
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      246. Fletterick RJ, Sygusch J, Semple H, Madsen NB. Structure of glycogen phosphorylase a at 3.0 A resolution and its ligand binding sites at 6 A. J Biol Chem. 1976 Oct 10; 251(19):6142-6.
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      247. Steitz TA, Fletterick RJ, Anderson WF, Anderson CM. High resolution x-ray structure of yeast hexokinase, an allosteric protein exhibiting a non-symmetric arrangement of subunits. J Mol Biol. 1976 Jun 14; 104(1):197-22.
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      248. Fletterick RJ, Sygusch J, Murray N, Madsen NB. Low-resolution structure of the glycogen phosphorylase alpha monomer and comparison with phosphorylase beta. J Mol Biol. 1976 May 5; 103(1):1-13.
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      249. Fletterick RJ, Bates DJ, Steitz TA. The structure of a yeast hexokinase monomer and its complexes with substrates at 2.7-A resolution. Proc Natl Acad Sci U S A. 1975 Jan; 72(1):38-42.
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      250. Anderson WF, Fletterick RJ, Steitz TA. Structure of yeast hexokinase. 3. Low resolution structure of a second crystal form showing a different quaternary structure, heterologous interaction of subunits and substrate binding. J Mol Biol. 1974 Jun 25; 86(2):261-9.
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      251. Steitz TA, Fletterick RJ, Hwang KJ. Structure of yeast hexokinase. II. A 6 angstrom resolution electron density map showing molecular shape and heterologous interaction of subunits. J Mol Biol. 1973 Aug 15; 78(3):551-61.
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      252. Fletterick RJ, Tsai C, Hughes RE. The crystal and molecular structure of L-alanyl-L-alanine. J Phys Chem. 1971 Apr 1; 75(7):918-22.
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      253. Fletterick RJ, Tsai CC, Hughes RE. The crystal and molecular structure of L-alanyl-L-alanine. J Phys Chem. 1971 Apr 1; 75(7):918-22.
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