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Robert Fletterick, PhD

TitleProfessor Emeritus
SchoolUCSF School of Medicine
DepartmentBiochemistry and Biophysics
Address600 16th St
San Francisco CA 94158
Phone415-476-5080
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    Collapse Research 
    Collapse Research Activities and Funding
    Screening for antagonists of nuclear receptor LRH-1 in pancreatic cancer cells
    NIH/NIMH R03MH094165Jan 15, 2012 - Dec 31, 2013
    Role: Principal Investigator
    Structures of Protein Complexes Regulating Transcription in Enbryonic Stem Cells
    NIH/NIGMS U01GM094614Sep 30, 2010 - Jun 30, 2015
    Role: Principal Investigator
    Nuclear receptor LRH-1 in pancreatic cancer
    NIH/NCI R21CA140751Mar 23, 2010 - Feb 29, 2012
    Role: Principal Investigator
    Imaging Nuclear Receptor LRH-1 in Functional Transcriptional Assemblies
    NIH/NIDDK R21DK084504Jun 1, 2009 - May 31, 2011
    Role: Principal Investigator
    Mechanisms of regulation of LRH-1, Nanog and SF-1 by DAX-1
    NIH/NIDDK R01DK078075Dec 10, 2007 - Nov 30, 2012
    Role: Principal Investigator
    A State-of-the-art BIACORE for UCSF Mission Bay
    NIH/NCRR S10RR023443Mar 23, 2007 - Mar 22, 2008
    Role: Principal Investigator
    Folding of Androgen Receptor-Coregulator Complex
    NIH/NIGMS R21GM077327Sep 25, 2006 - Aug 31, 2008
    Role: Principal Investigator
    Crystal Farm Imaging System
    NIH/NCRR S10RR022322Apr 15, 2006 - Apr 14, 2007
    Role: Principal Investigator
    REGULATION OF ORPHAN NUCLEAR RECEPTORS LRH-1 AND SF-1
    NIH/NIDDK R21DK067466Sep 30, 2004 - Aug 31, 2006
    Role: Principal Investigator
    CONFORMATIONAL CHANGES IN ACTIN
    NIH/NIGMS R01GM067830Aug 1, 2003 - Jul 31, 2007
    Role: Principal Investigator
    Inhibition of Androgen Receptor Activation
    NIH/NCI R21CA095324Jul 8, 2002 - Jun 30, 2004
    Role: Principal Investigator
    STRUCTURE AND DYNAMICS OF NUCLEAR RECEPTORS
    NIH/NIDDK P01DK058390Aug 15, 2000 - Jul 31, 2006
    Role: Principal Investigator
    NEUTRON STUDIES OF REGULATION OF VERTEBRATE MUSCLE
    NIH/NIAMS R01AR045659Sep 1, 1999 - Aug 31, 2005
    Role: Principal Investigator
    REGULATING NEUROTRANSMITTERS THROUGH MONOAMINE OXIDASES
    NIH/NINDS R01NS037495Jan 5, 1999 - Dec 31, 2003
    Role: Principal Investigator
    LINKING STRUCTURE TO RESPONSE IN THYROID RECEPTOR
    NIH/NIDDK R01DK053417Sep 28, 1998 - Aug 31, 2003
    Role: Principal Investigator
    Structure and Function of Molecular Motors
    NIH P01AR042895Jul 6, 1994 - Jun 30, 2010
    Role: Co-Investigator
    EXCELLENCE IN MOLECULAR BIOLOGY
    NIH P01HL043821Sep 30, 1989 - Nov 30, 1997
    Role: Co-Investigator
    PROTEASE SPECIFICITY AND INHIBITION
    NIH/NIDDK R01DK039304Mar 1, 1988 - Apr 30, 2004
    Role: Principal Investigator
    EVOLUTION OF ALLOSTERIC REGULATION IN PHOSPHORYLASE
    NIH/NIDDK R01DK032822Jan 1, 1984 - Jul 31, 2000
    Role: Principal Investigator
    PRIMARY AND TERTIARY STRUCTURES OF HUMAN PHOSPHORYLASES
    NIH/NIADDK R01AM032822Jan 1, 1984 - Dec 31, 1986
    Role: Principal Investigator
    Macromolecular Diffraction Resource: MacCHESS
    NIH P41RR001646Sep 1, 1983 - Jun 30, 2013
    Role: Co-Investigator
    MOLECULAR BIOLOGY OF CELLULAR GROWTH CONTROL
    NIH P01GM031286Feb 1, 1983 - Jan 31, 1993
    Role: Co-Investigator
    A Synchroton Radiation Structural Biology Resource
    NIH P41RR001209Mar 1, 1980 - Feb 28, 2015
    Role: Co-Investigator
    STRUCTURE-FUNCTION RELATIONSHIPS IN PHOSPHORYLASE A
    NIH/NIDDK R01DK026081Jul 1, 1979 - Jun 30, 1994
    Role: Principal Investigator
    STRUCTURE-FUNCTION RELATIONSHIPS IN PHOSPHORYLASE A
    NIH/NIADDK R01AM026081Jul 1, 1979 - Jun 30, 1989
    Role: Principal Investigator
    CNS DEGENERATION CAUSED BY NOVEL PATHOGENS
    NIH/NINDS P50NS014069Dec 1, 1977 - Nov 30, 2002
    Role: Co-Investigator

    Collapse ORNG Applications 
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    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Cortez FJ, Nguyen P, Truillet C, Tian B, Kuchenbecker KM, Evans MJ, Webb P, Jacobson MP, Fletterick RJ, England PM. Development of 5N-Bicalutamide, A High-affinity Reversible Covalent Antiandrogen. ACS Chem Biol. 2017 Oct 05. PMID: 28981251.
      View in: PubMed
    2. Fletterick R. NR5A2 discovering compounds that block tumor growth in PDAC. J Surg Oncol. 2017 Jul; 116(1):89-93. PMID: 28445593.
      View in: PubMed
    3. de Jesus Cortez F, Suzawa M, Irvy S, Bruning JM, Sablin E, Jacobson MP, Fletterick RJ, Ingraham HA, England PM. Disulfide-Trapping Identifies a New, Effective Chemical Probe for Activating the Nuclear Receptor Human LRH-1 (NR5A2). PLoS One. 2016; 11(7):e0159316. PMID: 27467220; PMCID: PMC4965143.
    4. Proudfoot A, Axelrod HL, Geralt M, Fletterick RJ, Yumoto F, Deacon AM, Elsliger MA, Wilson IA, Wüthrich K, Serrano P. Dlx5 Homeodomain:DNA Complex: Structure, Binding and Effect of Mutations Related to Split Hand and Foot Malformation Syndrome. J Mol Biol. 2016 Mar 27; 428(6):1130-1141. PMID: 26829219; PMCID: PMC4826628.
    5. Suzawa M, Miranda DA, Ramos KA, Ang KK, Faivre EJ, Wilson CG, Caboni L, Arkin MR, Kim YS, Fletterick R, Diaz A, Schneekloth JS, Ingraham HA. A gene-expression screen identifies a non-toxic sumoylation inhibitor that mimics SUMO-less human LRH-1 in liver. Elife. 2015 Dec 11; 4. PMID: 26653140; PMCID: PMC4749390.
    6. Sablin EP, Blind RD, Uthayaruban R, Chiu HJ, Deacon AM, Das D, Ingraham HA, Fletterick RJ. Structure of Liver Receptor Homolog-1 (NR5A2) with PIP3 hormone bound in the ligand binding pocket. J Struct Biol. 2015 Dec; 192(3):342-8. PMID: 26416531; PMCID: PMC4651778 [Available on 12/01/16].
    7. Storer Samaniego C, Suh JH, Chattopadhyay A, Olivares K, Guy N, Sivils JC, Dey P, Yumoto F, Fletterick RJ, Strom AM, Gustafsson JÅ, Webb P, Cox MB. The FKBP52 Cochaperone Acts in Synergy with ß-Catenin to Potentiate Androgen Receptor Signaling. PLoS One. 2015; 10(7):e0134015. PMID: 26207810; PMCID: PMC4514735.
    8. Hayashi Y, Caboni L, Das D, Yumoto F, Clayton T, Deller MC, Nguyen P, Farr CL, Chiu HJ, Miller MD, Elsliger MA, Deacon AM, Godzik A, Lesley SA, Tomoda K, Conklin BR, Wilson IA, Yamanaka S, Fletterick RJ. Structure-based discovery of NANOG variant with enhanced properties to promote self-renewal and reprogramming of pluripotent stem cells. Proc Natl Acad Sci U S A. 2015 Apr 14; 112(15):4666-71. PMID: 25825768; PMCID: PMC4403148.
    9. Torres IO, Kuchenbecker KM, Nnadi CI, Fletterick RJ, Kelly MJ, Fujimori DG. Histone demethylase KDM5A is regulated by its reader domain through a positive-feedback mechanism. Nat Commun. 2015 Feb 17; 6:6204. PMID: 25686748.
      View in: PubMed
    10. Bayrer JR, Mukkamala S, Sablin EP, Webb P, Fletterick RJ. Silencing LRH-1 in colon cancer cell lines impairs proliferation and alters gene expression programs. Proc Natl Acad Sci U S A. 2015 Feb 24; 112(8):2467-72. PMID: 25675535; PMCID: PMC4345603.
    11. Gallastegui N, Mackinnon JA, Fletterick RJ, Estébanez-Perpiñá E. Advances in our structural understanding of orphan nuclear receptors. Trends Biochem Sci. 2015 Jan; 40(1):25-35. PMID: 25499868.
      View in: PubMed
    12. Blind RD, Sablin EP, Kuchenbecker KM, Chiu HJ, Deacon AM, Das D, Fletterick RJ, Ingraham HA. The signaling phospholipid PIP3 creates a new interaction surface on the nuclear receptor SF-1. Proc Natl Acad Sci U S A. 2014 Oct 21; 111(42):15054-9. PMID: 25288771; PMCID: PMC4210282.
    13. Nagavalli S, Fletterick RJ, Ford G, Boston BA, Gianoukakis AG. Computer modeling of a newly identified THRB gene mutation (S350L) associated with resistance to thyroid hormone in three unrelated patients. Thyroid. 2014 Sep; 24(9):1430-1. PMID: 24906004; PMCID: PMC4361411.
    14. Benod C, Villagomez R, Filgueira CS, Hwang PK, Leonard PG, Poncet-Montange G, Rajagopalan S, Fletterick RJ, Gustafsson JÅ, Webb P. The human orphan nuclear receptor tailless (TLX, NR2E1) is druggable. PLoS One. 2014; 9(6):e99440. PMID: 24936658; PMCID: PMC4060991.
    15. Bhattacharya S, Lou X, Hwang P, Rajashankar KR, Wang X, Gustafsson JÅ, Fletterick RJ, Jacobson RH, Webb P. Structural and functional insight into TAF1-TAF7, a subcomplex of transcription factor II D. Proc Natl Acad Sci U S A. 2014 Jun 24; 111(25):9103-8. PMID: 24927529; PMCID: PMC4078864.
    16. Larsen CC, Dumitrescu A, Guerra-Argüero LM, Gállego-Suárez C, Vazquez-Mellado A, Vinogradova M, Fletterick R, Refetoff S, Weiss RE. Incidental identification of a thyroid hormone receptor beta (THRB) gene variant in a family with autoimmune thyroid disease. Thyroid. 2013 Dec; 23(12):1638-43. PMID: 23806029; PMCID: PMC3868256.
    17. Vinogradova MV, Malanina GG, Waitzman JS, Rice SE, Fletterick RJ. Plant Kinesin-Like Calmodulin Binding Protein Employs Its Regulatory Domain for Dimerization. PLoS One. 2013; 8(6):e66669. PMID: 23805258; PMCID: PMC3689661.
    18. Benod C, Carlsson J, Uthayaruban R, Hwang P, Irwin JJ, Doak AK, Shoichet BK, Sablin EP, Fletterick RJ. Structure-based discovery of antagonists of nuclear receptor LRH-1. J Biol Chem. 2013 Jul 05; 288(27):19830-44. PMID: 23667258; PMCID: PMC3707686.
    19. Kumar A, Möcklinghoff S, Yumoto F, Jaroszewski L, Farr CL, Grzechnik A, Nguyen P, Weichenberger CX, Chiu HJ, Klock HE, Elsliger MA, Deacon AM, Godzik A, Lesley SA, Conklin BR, Fletterick RJ, Wilson IA. Structure of a novel winged-helix like domain from human NFRKB protein. PLoS One. 2012; 7(9):e43761. PMID: 22984442; PMCID: PMC3439487.
    20. Yumoto F, Nguyen P, Sablin EP, Baxter JD, Webb P, Fletterick RJ. Structural basis of coactivation of liver receptor homolog-1 by ß-catenin. Proc Natl Acad Sci U S A. 2012 Jan 03; 109(1):143-8. PMID: 22187462; PMCID: PMC3252924.
    21. Benod C, Vinogradova MV, Jouravel N, Kim GE, Fletterick RJ, Sablin EP. Nuclear receptor liver receptor homologue 1 (LRH-1) regulates pancreatic cancer cell growth and proliferation. Proc Natl Acad Sci U S A. 2011 Oct 11; 108(41):16927-31. PMID: 21949357; PMCID: PMC3193228.
    22. Buzón V, Carbó LR, Estruch SB, Fletterick RJ, Estébanez-Perpiñá E. A conserved surface on the ligand binding domain of nuclear receptors for allosteric control. Mol Cell Endocrinol. 2012 Jan 30; 348(2):394-402. PMID: 21878368.
      View in: PubMed
    23. De Leon JT, Iwai A, Feau C, Garcia Y, Balsiger HA, Storer CL, Suro RM, Garza KM, Lee S, Kim YS, Chen Y, Ning YM, Riggs DL, Fletterick RJ, Guy RK, Trepel JB, Neckers LM, Cox MB. Targeting the regulation of androgen receptor signaling by the heat shock protein 90 cochaperone FKBP52 in prostate cancer cells. Proc Natl Acad Sci U S A. 2011 Jul 19; 108(29):11878-83. PMID: 21730179; PMCID: PMC3141981.
    24. Hjelm RP, Stone DB, Fletterick RJ, Mendelson RA. Decoration of microtubules in solution by the kinesin-14, Ncd. Acta Crystallogr D Biol Crystallogr. 2010 Nov; 66(Pt 11):1218-23. PMID: 21041940; PMCID: PMC4983869.
    25. Wilbur JD, Hwang PK, Ybe JA, Lane M, Sellers BD, Jacobson MP, Fletterick RJ, Brodsky FM. Conformation switching of clathrin light chain regulates clathrin lattice assembly. Dev Cell. 2010 May 18; 18(5):841-8. PMID: 20493816; PMCID: PMC2975025.
    26. Pfaff SJ, Fletterick RJ. Hormone binding and co-regulator binding to the glucocorticoid receptor are allosterically coupled. J Biol Chem. 2010 May 14; 285(20):15256-67. PMID: 20335180; PMCID: PMC2865338.
    27. Wilbur JD, Hwang PK, Brodsky FM, Fletterick RJ. Accommodation of structural rearrangements in the huntingtin-interacting protein 1 coiled-coil domain. Acta Crystallogr D Biol Crystallogr. 2010 Mar; 66(Pt 3):314-8. PMID: 20179344; PMCID: PMC2827350.
    28. Vinogradova MV, Malanina GG, Reddy AS, Fletterick RJ. Structure of the complex of a mitotic kinesin with its calcium binding regulator. Proc Natl Acad Sci U S A. 2009 May 19; 106(20):8175-9. PMID: 19416847; PMCID: PMC2688874.
    29. Jouravel N, Sablin E, Togashi M, Baxter JD, Webb P, Fletterick RJ. Molecular basis for dimer formation of TRbeta variant D355R. Proteins. 2009 Apr; 75(1):111-7. PMID: 18798561; PMCID: PMC2649980.
    30. Sablin EP, Woods A, Krylova IN, Hwang P, Ingraham HA, Fletterick RJ. The structure of corepressor Dax-1 bound to its target nuclear receptor LRH-1. Proc Natl Acad Sci U S A. 2008 Nov 25; 105(47):18390-5. PMID: 19015525; PMCID: PMC2587556.
    31. Sablin EP, Blind RD, Krylova IN, Ingraham JG, Cai F, Williams JD, Fletterick RJ, Ingraham HA. Structure of SF-1 bound by different phospholipids: evidence for regulatory ligands. Mol Endocrinol. 2009 Jan; 23(1):25-34. PMID: 18988706; PMCID: PMC2646595.
    32. Cruz LA, Estébanez-Perpiñá E, Pfaff S, Borngraeber S, Bao N, Blethrow J, Fletterick RJ, England PM. 6-Azido-7-nitro-1,4-dihydroquinoxaline-2,3-dione (ANQX) forms an irreversible bond to the active site of the GluR2 AMPA receptor. J Med Chem. 2008 Sep 25; 51(18):5856-60. PMID: 18754610; PMCID: PMC2945402.
    33. Wilbur JD, Chen CY, Manalo V, Hwang PK, Fletterick RJ, Brodsky FM. Actin binding by Hip1 (huntingtin-interacting protein 1) and Hip1R (Hip1-related protein) is regulated by clathrin light chain. J Biol Chem. 2008 Nov 21; 283(47):32870-9. PMID: 18790740; PMCID: PMC2583295.
    34. Vinogradova MV, Malanina GG, Reddy VS, Reddy AS, Fletterick RJ. Structural dynamics of the microtubule binding and regulatory elements in the kinesin-like calmodulin binding protein. J Struct Biol. 2008 Jul; 163(1):76-83. PMID: 18513992.
      View in: PubMed
    35. Jouravel N, Sablin E, Arnold LA, Guy RK, Fletterick RJ. Interaction between the androgen receptor and a segment of its corepressor SHP. Acta Crystallogr D Biol Crystallogr. 2007 Nov; 63(Pt 11):1198-200. PMID: 18007036.
      View in: PubMed
    36. Arnold LA, Kosinski A, Estébanez-Perpiñá E, Fletterick RJ, Guy RK. Inhibitors of the interaction of a thyroid hormone receptor and coactivators: preliminary structure-activity relationships. J Med Chem. 2007 Nov 01; 50(22):5269-80. PMID: 17918822; PMCID: PMC2536611.
    37. Estébanez-Perpiñá E, Arnold LA, Arnold AA, Nguyen P, Rodrigues ED, Mar E, Bateman R, Pallai P, Shokat KM, Baxter JD, Guy RK, Webb P, Fletterick RJ. A surface on the androgen receptor that allosterically regulates coactivator binding. Proc Natl Acad Sci U S A. 2007 Oct 09; 104(41):16074-9. PMID: 17911242; PMCID: PMC1999396.
    38. Estébanez-Perpiñá E, Jouravel N, Fletterick RJ. Perspectives on designs of antiandrogens for prostate cancer. Expert Opin Drug Discov. 2007 Oct; 2(10):1341-55. PMID: 23484530.
      View in: PubMed
    39. Estébanez-Perpiñá E, Arnold LA, Jouravel N, Togashi M, Blethrow J, Mar E, Nguyen P, Phillips KJ, Baxter JD, Webb P, Guy RK, Fletterick RJ. Structural insight into the mode of action of a direct inhibitor of coregulator binding to the thyroid hormone receptor. Mol Endocrinol. 2007 Dec; 21(12):2919-28. PMID: 17823305.
      View in: PubMed
    40. Wang SX, Pandey KC, Scharfstein J, Whisstock J, Huang RK, Jacobelli J, Fletterick RJ, Rosenthal PJ, Abrahamson M, Brinen LS, Rossi A, Sali A, McKerrow JH. The structure of chagasin in complex with a cysteine protease clarifies the binding mode and evolution of an inhibitor family. Structure. 2007 May; 15(5):535-43. PMID: 17502099.
      View in: PubMed
    41. Vinogradova MV, Stone DB, Malanina GG, Mendelson RA, Fletterick RJ. Ca ion and the troponin switch. Adv Exp Med Biol. 2007; 592:47-57. PMID: 17278355.
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    42. Wang SX, Pandey KC, Somoza JR, Sijwali PS, Kortemme T, Brinen LS, Fletterick RJ, Rosenthal PJ, McKerrow JH. Structural basis for unique mechanisms of folding and hemoglobin binding by a malarial protease. Proc Natl Acad Sci U S A. 2006 Aug 01; 103(31):11503-8. PMID: 16864794; PMCID: PMC1544199.
    43. Luginbühl B, Kanyo Z, Jones RM, Fletterick RJ, Prusiner SB, Cohen FE, Williamson RA, Burton DR, Plückthun A. Directed evolution of an anti-prion protein scFv fragment to an affinity of 1 pM and its structural interpretation. J Mol Biol. 2006 Oct 13; 363(1):75-97. PMID: 16962610.
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    44. Arnold LA, Estébanez-Perpiñá E, Togashi M, Shelat A, Ocasio CA, McReynolds AC, Nguyen P, Baxter JD, Fletterick RJ, Webb P, Guy RK. A high-throughput screening method to identify small molecule inhibitors of thyroid hormone receptor coactivator binding. Sci STKE. 2006 Jun 27; 2006(341):pl3. PMID: 16804159.
      View in: PubMed
    45. Pirani A, Vinogradova MV, Curmi PM, King WA, Fletterick RJ, Craig R, Tobacman LS, Xu C, Hatch V, Lehman W. An atomic model of the thin filament in the relaxed and Ca2+-activated states. J Mol Biol. 2006 Mar 31; 357(3):707-17. PMID: 16469331.
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    46. Blumenschein TM, Stone DB, Fletterick RJ, Mendelson RA, Sykes BD. Dynamics of the C-terminal region of TnI in the troponin complex in solution. Biophys J. 2006 Apr 01; 90(7):2436-44. PMID: 16415057; PMCID: PMC1403181.
    47. Fletterick RJ. Molecular modelling of the androgen receptor axis: rational basis for androgen receptor intervention in androgen-independent prostate cancer. BJU Int. 2005 Dec; 96 Suppl 2:2-9. PMID: 16359432.
      View in: PubMed
    48. Arnold LA, Estébanez-Perpiñá E, Togashi M, Jouravel N, Shelat A, McReynolds AC, Mar E, Nguyen P, Baxter JD, Fletterick RJ, Webb P, Guy RK. Discovery of small molecule inhibitors of the interaction of the thyroid hormone receptor with transcriptional coregulators. J Biol Chem. 2005 Dec 30; 280(52):43048-55. PMID: 16263725.
      View in: PubMed
    49. Togashi M, Nguyen P, Fletterick R, Baxter JD, Webb P. Rearrangements in thyroid hormone receptor charge clusters that stabilize bound 3,5',5-triiodo-L-thyronine and inhibit homodimer formation. J Biol Chem. 2005 Jul 08; 280(27):25665-73. PMID: 15886199.
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    50. Blumenschein TM, Stone DB, Fletterick RJ, Mendelson RA, Sykes BD. Calcium-dependent changes in the flexibility of the regulatory domain of troponin C in the troponin complex. J Biol Chem. 2005 Jun 10; 280(23):21924-32. PMID: 15826946.
      View in: PubMed
    51. Vinogradova MV, Stone DB, Malanina GG, Karatzaferi C, Cooke R, Mendelson RA, Fletterick RJ. Ca(2+)-regulated structural changes in troponin. Proc Natl Acad Sci U S A. 2005 Apr 05; 102(14):5038-43. PMID: 15784741; PMCID: PMC555973.
    52. Togashi M, Borngraeber S, Sandler B, Fletterick RJ, Webb P, Baxter JD. Conformational adaptation of nuclear receptor ligand binding domains to agonists: potential for novel approaches to ligand design. J Steroid Biochem Mol Biol. 2005 Feb; 93(2-5):127-37. PMID: 15860255.
      View in: PubMed
    53. Krylova IN, Sablin EP, Moore J, Xu RX, Waitt GM, MacKay JA, Juzumiene D, Bynum JM, Madauss K, Montana V, Lebedeva L, Suzawa M, Williams JD, Williams SP, Guy RK, Thornton JW, Fletterick RJ, Willson TM, Ingraham HA. Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1. Cell. 2005 Feb 11; 120(3):343-55. PMID: 15707893.
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    54. Estébanez-Perpiñá E, Moore JM, Mar E, Delgado-Rodrigues E, Nguyen P, Baxter JD, Buehrer BM, Webb P, Fletterick RJ, Guy RK. The molecular mechanisms of coactivator utilization in ligand-dependent transactivation by the androgen receptor. J Biol Chem. 2005 Mar 04; 280(9):8060-8. PMID: 15563469.
      View in: PubMed
    55. Sandler B, Webb P, Apriletti JW, Huber BR, Togashi M, Cunha Lima ST, Juric S, Nilsson S, Wagner R, Fletterick RJ, Baxter JD. Thyroxine-thyroid hormone receptor interactions. J Biol Chem. 2004 Dec 31; 279(53):55801-8. PMID: 15466465.
      View in: PubMed
    56. Hur E, Pfaff SJ, Payne ES, Grøn H, Buehrer BM, Fletterick RJ. Recognition and accommodation at the androgen receptor coactivator binding interface. PLoS Biol. 2004 Sep; 2(9):E274. PMID: 15328534; PMCID: PMC509409.
    57. Ruggles SW, Fletterick RJ, Craik CS. Characterization of structural determinants of granzyme B reveals potent mediators of extended substrate specificity. J Biol Chem. 2004 Jul 16; 279(29):30751-9. PMID: 15123647.
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    58. Shipley K, Hekmat-Nejad M, Turner J, Moores C, Anderson R, Milligan R, Sakowicz R, Fletterick R. Structure of a kinesin microtubule depolymerization machine. EMBO J. 2004 Apr 07; 23(7):1422-32. PMID: 15029249; PMCID: PMC391071.
    59. Vinogradova MV, Reddy VS, Reddy AS, Sablin EP, Fletterick RJ. Crystal structure of kinesin regulated by Ca(2+)-calmodulin. J Biol Chem. 2004 May 28; 279(22):23504-9. PMID: 14988396.
      View in: PubMed
    60. Sablin EP, Fletterick RJ. Coordination between motor domains in processive kinesins. J Biol Chem. 2004 Apr 16; 279(16):15707-10. PMID: 14973135.
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    61. Borngraeber S, Budny MJ, Chiellini G, Cunha-Lima ST, Togashi M, Webb P, Baxter JD, Scanlan TS, Fletterick RJ. Ligand selectivity by seeking hydrophobicity in thyroid hormone receptor. Proc Natl Acad Sci U S A. 2003 Dec 23; 100(26):15358-63. PMID: 14673100; PMCID: PMC307572.
    62. Wang SX, Hur E, Sousa CA, Brinen L, Slivka EJ, Fletterick RJ. The extended interactions and Gla domain of blood coagulation factor Xa. Biochemistry. 2003 Jul 08; 42(26):7959-66. PMID: 12834348.
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    63. Bell JK, Goetz DH, Mahrus S, Harris JL, Fletterick RJ, Craik CS. The oligomeric structure of human granzyme A is a determinant of its extended substrate specificity. Nat Struct Biol. 2003 Jul; 10(7):527-34. PMID: 12819769.
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    64. Sablin EP, Krylova IN, Fletterick RJ, Ingraham HA. Structural basis for ligand-independent activation of the orphan nuclear receptor LRH-1. Mol Cell. 2003 Jun; 11(6):1575-85. PMID: 12820970.
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    65. Huber BR, Sandler B, West BL, Cunha Lima ST, Nguyen HT, Apriletti JW, Baxter JD, Fletterick RJ. Two resistance to thyroid hormone mutants with impaired hormone binding. Mol Endocrinol. 2003 Apr; 17(4):643-52. PMID: 12554782.
      View in: PubMed
    66. Huber BR, Desclozeaux M, West BL, Cunha-Lima ST, Nguyen HT, Baxter JD, Ingraham HA, Fletterick RJ. Thyroid hormone receptor-beta mutations conferring hormone resistance and reduced corepressor release exhibit decreased stability in the N-terminal ligand-binding domain. Mol Endocrinol. 2003 Jan; 17(1):107-16. PMID: 12511610.
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    67. Webb P, Nguyen NH, Chiellini G, Yoshihara HA, Cunha Lima ST, Apriletti JW, Ribeiro RC, Marimuthu A, West BL, Goede P, Mellstrom K, Nilsson S, Kushner PJ, Fletterick RJ, Scanlan TS, Baxter JD. Design of thyroid hormone receptor antagonists from first principles. J Steroid Biochem Mol Biol. 2002 Dec; 83(1-5):59-73. PMID: 12650702.
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    68. Sindelar CV, Budny MJ, Rice S, Naber N, Fletterick R, Cooke R. Two conformations in the human kinesin power stroke defined by X-ray crystallography and EPR spectroscopy. Nat Struct Biol. 2002 Nov; 9(11):844-8. PMID: 12368902.
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    69. Desclozeaux M, Krylova IN, Horn F, Fletterick RJ, Ingraham HA. Phosphorylation and intramolecular stabilization of the ligand binding domain in the nuclear receptor steroidogenic factor 1. Mol Cell Biol. 2002 Oct; 22(20):7193-203. PMID: 12242296; PMCID: PMC139795.
    70. Dawson JF, Sablin EP, Spudich JA, Fletterick RJ. Structure of an F-actin trimer disrupted by gelsolin and implications for the mechanism of severing. J Biol Chem. 2003 Jan 10; 278(2):1229-38. PMID: 12356759.
      View in: PubMed
    71. Sablin EP, Dawson JF, VanLoock MS, Spudich JA, Egelman EH, Fletterick RJ. How does ATP hydrolysis control actin's associations? Proc Natl Acad Sci U S A. 2002 Aug 20; 99(17):10945-7. PMID: 12167670; PMCID: PMC123189.
    72. Ekstrom JL, Pauly TA, Carty MD, Soeller WC, Culp J, Danley DE, Hoover DJ, Treadway JL, Gibbs EM, Fletterick RJ, Day YS, Myszka DG, Rath VL. Structure-activity analysis of the purine binding site of human liver glycogen phosphorylase. Chem Biol. 2002 Aug; 9(8):915-24. PMID: 12204691.
      View in: PubMed
    73. Walther M, Anton M, Wiedmann M, Fletterick R, Kuhn H. The N-terminal domain of the reticulocyte-type 15-lipoxygenase is not essential for enzymatic activity but contains determinants for membrane binding. J Biol Chem. 2002 Jul 26; 277(30):27360-6. PMID: 12004065.
      View in: PubMed
    74. Laboissière MC, Young MM, Pinho RG, Todd S, Fletterick RJ, Kuntz I, Craik CS. Computer-assisted mutagenesis of ecotin to engineer its secondary binding site for urokinase inhibition. J Biol Chem. 2002 Jul 19; 277(29):26623-31. PMID: 11959867.
      View in: PubMed
    75. Marimuthu A, Feng W, Tagami T, Nguyen H, Jameson JL, Fletterick RJ, Baxter JD, West BL. TR surfaces and conformations required to bind nuclear receptor corepressor. Mol Endocrinol. 2002 Feb; 16(2):271-86. PMID: 11818500.
      View in: PubMed
    76. Baxter JD, Goede P, Apriletti JW, West BL, Feng W, Mellstrom K, Fletterick RJ, Wagner RL, Kushner PJ, Ribeiro RC, Webb P, Scanlan TS, Nilsson S. Structure-based design and synthesis of a thyroid hormone receptor (TR) antagonist. Endocrinology. 2002 Feb; 143(2):517-24. PMID: 11796506.
      View in: PubMed
    77. Sablin EP, Fletterick RJ. Nucleotide switches in molecular motors: structural analysis of kinesins and myosins. Curr Opin Struct Biol. 2001 Dec; 11(6):716-24. PMID: 11751053.
      View in: PubMed
    78. Martín MA, Rubio JC, Buchbinder J, Fernández-Hojas R, del Hoyo P, Teijeira S, Gámez J, Navarro C, Fernández JM, Cabello A, Campos Y, Cervera C, Culebras JM, Andreu AL, Fletterick R, Arenas J. Molecular heterogeneity of myophosphorylase deficiency (McArdle's disease): a genotype-phenotype correlation study. Ann Neurol. 2001 Nov; 50(5):574-81. PMID: 11706962.
      View in: PubMed
    79. Wang SX, Esmon CT, Fletterick RJ. Crystal structure of thrombin-ecotin reveals conformational changes and extended interactions. Biochemistry. 2001 Aug 28; 40(34):10038-46. PMID: 11513582.
      View in: PubMed
    80. Kikkawa M, Sablin EP, Okada Y, Yajima H, Fletterick RJ, Hirokawa N. Switch-based mechanism of kinesin motors. Nature. 2001 May 24; 411(6836):439-45. PMID: 11373668.
      View in: PubMed
    81. Eggers CT, Wang SX, Fletterick RJ, Craik CS. The role of ecotin dimerization in protease inhibition. J Mol Biol. 2001 May 18; 308(5):975-91. PMID: 11352586.
      View in: PubMed
    82. Turner J, Anderson R, Guo J, Beraud C, Fletterick R, Sakowicz R. Crystal structure of the mitotic spindle kinesin Eg5 reveals a novel conformation of the neck-linker. J Biol Chem. 2001 Jul 06; 276(27):25496-502. PMID: 11328809.
      View in: PubMed
    83. Wagner RL, Huber BR, Shiau AK, Kelly A, Cunha Lima ST, Scanlan TS, Apriletti JW, Baxter JD, West BL, Fletterick RJ. Hormone selectivity in thyroid hormone receptors. Mol Endocrinol. 2001 Mar; 15(3):398-410. PMID: 11222741.
      View in: PubMed
    84. Ribeiro RC, Feng W, Wagner RL, Costa CH, Pereira AC, Apriletti JW, Fletterick RJ, Baxter JD. Definition of the surface in the thyroid hormone receptor ligand binding domain for association as homodimers and heterodimers with retinoid X receptor. J Biol Chem. 2001 May 04; 276(18):14987-95. PMID: 11145963.
      View in: PubMed
    85. Buchbinder JL, Rath VL, Fletterick RJ. Structural relationships among regulated and unregulated phosphorylases. Annu Rev Biophys Biomol Struct. 2001; 30:191-209. PMID: 11340058.
      View in: PubMed
    86. Baxter JD, Dillmann WH, West BL, Huber R, Furlow JD, Fletterick RJ, Webb P, Apriletti JW, Scanlan TS. Selective modulation of thyroid hormone receptor action. J Steroid Biochem Mol Biol. 2001 Jan-Mar; 76(1-5):31-42. PMID: 11384861.
      View in: PubMed
    87. Kapila Y, Doan D, Tafolla E, Fletterick R. Three-dimensional structural analysis of fibronectin heparin-binding domain mutations. J Cell Biochem Suppl. 2001; Suppl 36:156-61. PMID: 11455580.
      View in: PubMed
    88. Waugh SM, Harris JL, Fletterick R, Craik CS. The structure of the pro-apoptotic protease granzyme B reveals the molecular determinants of its specificity. Nat Struct Biol. 2000 Sep; 7(9):762-5. PMID: 10966646.
      View in: PubMed
    89. Gillmor SA, Takeuchi T, Yang SQ, Craik CS, Fletterick RJ. Compromise and accommodation in ecotin, a dimeric macromolecular inhibitor of serine proteases. J Mol Biol. 2000 Jun 16; 299(4):993-1003. PMID: 10843853.
      View in: PubMed
    90. Vale RD, Case R, Sablin E, Hart C, Fletterick R. Searching for kinesin's mechanical amplifier. Philos Trans R Soc Lond B Biol Sci. 2000 Apr 29; 355(1396):449-57. PMID: 10836498; PMCID: PMC1692751.
    91. Borngräber S, Browner M, Gillmor S, Gerth C, Anton M, Fletterick R, Kühn H. Shape and specificity in mammalian 15-lipoxygenase active site. The functional interplay of sequence determinants for the reaction specificity. J Biol Chem. 1999 Dec 24; 274(52):37345-50. PMID: 10601303.
      View in: PubMed
    92. Han Y, Sablin EP, Nogales E, Fletterick RJ, Downing KH. Visualizing a new binding site of ncd-motor domain on tubulin. J Struct Biol. 1999 Dec 01; 128(1):26-33. PMID: 10600555.
      View in: PubMed
    93. Kanyo ZF, Pan KM, Williamson RA, Burton DR, Prusiner SB, Fletterick RJ, Cohen FE. Antibody binding defines a structure for an epitope that participates in the PrPC-->PrPSc conformational change. J Mol Biol. 1999 Nov 05; 293(4):855-63. PMID: 10543972.
      View in: PubMed
    94. Norman AW, Adams D, Collins ED, Okamura WH, Fletterick RJ. Three-dimensional model of the ligand binding domain of the nuclear receptor for 1alpha,25-dihydroxy-vitamin D(3). J Cell Biochem. 1999 Sep 01; 74(3):323-33. PMID: 10412035.
      View in: PubMed
    95. Ybe JA, Brodsky FM, Hofmann K, Lin K, Liu SH, Chen L, Earnest TN, Fletterick RJ, Hwang PK. Clathrin self-assembly is mediated by a tandemly repeated superhelix. Nature. 1999 May 27; 399(6734):371-5. PMID: 10360576.
      View in: PubMed
    96. Weatherman RV, Fletterick RJ, Scanlan TS. Nuclear-receptor ligands and ligand-binding domains. Annu Rev Biochem. 1999; 68:559-81. PMID: 10872460.
      View in: PubMed
    97. Butte MJ, Hwang PK, Mobley WC, Fletterick RJ. Crystal structure of neurotrophin-3 homodimer shows distinct regions are used to bind its receptors. Biochemistry. 1998 Dec 01; 37(48):16846-52. PMID: 9836577.
      View in: PubMed
    98. Darimont BD, Wagner RL, Apriletti JW, Stallcup MR, Kushner PJ, Baxter JD, Fletterick RJ, Yamamoto KR. Structure and specificity of nuclear receptor-coactivator interactions. Genes Dev. 1998 Nov 01; 12(21):3343-56. PMID: 9808622; PMCID: PMC317236.
    99. Apriletti JW, Ribeiro RC, Wagner RL, Feng W, Webb P, Kushner PJ, West BL, Nilsson S, Scanlan TS, Fletterick RJ, Baxter JD. Molecular and structural biology of thyroid hormone receptors. Clin Exp Pharmacol Physiol Suppl. 1998 Nov; 25:S2-11. PMID: 9809185.
      View in: PubMed
    100. Kull FJ, Vale RD, Fletterick RJ. The case for a common ancestor: kinesin and myosin motor proteins and G proteins. J Muscle Res Cell Motil. 1998 Nov; 19(8):877-86. PMID: 10047987.
      View in: PubMed
    101. Focia PJ, Craig SP, Nieves-Alicea R, Fletterick RJ, Eakin AE. A 1.4 A crystal structure for the hypoxanthine phosphoribosyltransferase of Trypanosoma cruzi. Biochemistry. 1998 Oct 27; 37(43):15066-75. PMID: 9790669.
      View in: PubMed
    102. Sablin EP, Case RB, Dai SC, Hart CL, Ruby A, Vale RD, Fletterick RJ. Direction determination in the minus-end-directed kinesin motor ncd. Nature. 1998 Oct 22; 395(6704):813-6. PMID: 9796817.
      View in: PubMed
    103. Buchbinder JL, Stephenson RC, Scanlan TS, Fletterick RJ. A comparison of the crystallographic structures of two catalytic antibodies with esterase activity. J Mol Biol. 1998 Oct 09; 282(5):1033-41. PMID: 9753552.
      View in: PubMed
    104. Collingwood TN, Wagner R, Matthews CH, Clifton-Bligh RJ, Gurnell M, Rajanayagam O, Agostini M, Fletterick RJ, Beck-Peccoz P, Reinhardt W, Binder G, Ranke MB, Hermus A, Hesch RD, Lazarus J, Newrick P, Parfitt V, Raggatt P, de Zegher F, Chatterjee VK. A role for helix 3 of the TRbeta ligand-binding domain in coactivator recruitment identified by characterization of a third cluster of mutations in resistance to thyroid hormone. EMBO J. 1998 Aug 17; 17(16):4760-70. PMID: 9707435; PMCID: PMC1170805.
    105. Kull FJ, Fletterick RJ. Is the tubulin/FtsZ fold related to the G-protein fold? Trends Cell Biol. 1998 Aug; 8(8):306-7. PMID: 9704406.
      View in: PubMed
    106. Yang SQ, Wang CI, Gillmor SA, Fletterick RJ, Craik CS. Ecotin: a serine protease inhibitor with two distinct and interacting binding sites. J Mol Biol. 1998 Jun 19; 279(4):945-57. PMID: 9642073.
      View in: PubMed
    107. Feng W, Ribeiro RC, Wagner RL, Nguyen H, Apriletti JW, Fletterick RJ, Baxter JD, Kushner PJ, West BL. Hormone-dependent coactivator binding to a hydrophobic cleft on nuclear receptors. Science. 1998 Jun 12; 280(5370):1747-9. PMID: 9624051.
      View in: PubMed
    108. Clifton-Bligh RJ, de Zegher F, Wagner RL, Collingwood TN, Francois I, Van Helvoirt M, Fletterick RJ, Chatterjee VK. A novel TR beta mutation (R383H) in resistance to thyroid hormone syndrome predominantly impairs corepressor release and negative transcriptional regulation. Mol Endocrinol. 1998 May; 12(5):609-21. PMID: 9605924.
      View in: PubMed
    109. Somoza JR, Skillman AG, Munagala NR, Oshiro CM, Knegtel RM, Mpoke S, Fletterick RJ, Kuntz ID, Wang CC. Rational design of novel antimicrobials: blocking purine salvage in a parasitic protozoan. Biochemistry. 1998 Apr 21; 37(16):5344-8. PMID: 9548915.
      View in: PubMed
    110. Buchbinder JL, Stephenson RC, Dresser MJ, Pitera JW, Scanlan TS, Fletterick RJ. Biochemical characterization and crystallographic structure of an Escherichia coli protein from the phosphotriesterase gene family. Biochemistry. 1998 Apr 14; 37(15):5096-106. PMID: 9548740.
      View in: PubMed
    111. Ribeiro RC, Apriletti JW, Wagner RL, Feng W, Kushner PJ, Nilsson S, Scanlan TS, West BL, Fletterick RJ, Baxter JD. X-ray crystallographic and functional studies of thyroid hormone receptor. J Steroid Biochem Mol Biol. 1998 Apr; 65(1-6):133-41. PMID: 9699866.
      View in: PubMed
    112. Zhang YH, Guo W, Wagner RL, Huang BL, McCabe L, Vilain E, Burris TP, Anyane-Yeboa K, Burghes AH, Chitayat D, Chudley AE, Genel M, Gertner JM, Klingensmith GJ, Levine SN, Nakamoto J, New MI, Pagon RA, Pappas JG, Quigley CA, Rosenthal IM, Baxter JD, Fletterick RJ, McCabe ER. DAX1 mutations map to putative structural domains in a deduced three-dimensional model. Am J Hum Genet. 1998 Apr; 62(4):855-64. PMID: 9529340; PMCID: PMC1377022.
    113. Ribeiro RC, Apriletti JW, Wagner RL, West BL, Feng W, Huber R, Kushner PJ, Nilsson S, Scanlan T, Fletterick RJ, Schaufele F, Baxter JD. Mechanisms of thyroid hormone action: insights from X-ray crystallographic and functional studies. Recent Prog Horm Res. 1998; 53:351-92; discussion 392-4. PMID: 9769715.
      View in: PubMed
    114. Gillmor SA, Villaseñor A, Fletterick R, Sigal E, Browner MF. The structure of mammalian 15-lipoxygenase reveals similarity to the lipases and the determinants of substrate specificity. Nat Struct Biol. 1997 Dec; 4(12):1003-9. PMID: 9406550.
      View in: PubMed
    115. Lin K, Hwang PK, Fletterick RJ. Distinct phosphorylation signals converge at the catalytic center in glycogen phosphorylases. Structure. 1997 Nov 15; 5(11):1511-23. PMID: 9384566.
      View in: PubMed
    116. Whitby FG, Luecke H, Kuhn P, Somoza JR, Huete-Perez JA, Phillips JD, Hill CP, Fletterick RJ, Wang CC. Crystal structure of Tritrichomonas foetus inosine-5'-monophosphate dehydrogenase and the enzyme-product complex. Biochemistry. 1997 Sep 02; 36(35):10666-74. PMID: 9271497.
      View in: PubMed
    117. Gillmor SA, Craik CS, Fletterick RJ. Structural determinants of specificity in the cysteine protease cruzain. Protein Sci. 1997 Aug; 6(8):1603-11. PMID: 9260273; PMCID: PMC2143760.
    118. Sosa H, Dias DP, Hoenger A, Whittaker M, Wilson-Kubalek E, Sablin E, Fletterick RJ, Vale RD, Milligan RA. A model for the microtubule-Ncd motor protein complex obtained by cryo-electron microscopy and image analysis. Cell. 1997 Jul 25; 90(2):217-24. PMID: 9244296.
      View in: PubMed
    119. Buchbinder JL, Luong CB, Browner MF, Fletterick RJ. Partial activation of muscle phosphorylase by replacement of serine 14 with acidic residues at the site of regulatory phosphorylation. Biochemistry. 1997 Jul 01; 36(26):8039-44. PMID: 9201951.
      View in: PubMed
    120. Perona JJ, Tsu CA, Craik CS, Fletterick RJ. Crystal structure of an ecotin-collagenase complex suggests a model for recognition and cleavage of the collagen triple helix. Biochemistry. 1997 May 06; 36(18):5381-92. PMID: 9154920.
      View in: PubMed
    121. Tsu CA, Perona JJ, Fletterick RJ, Craik CS. Structural basis for the broad substrate specificity of fiddler crab collagenolytic serine protease 1. Biochemistry. 1997 May 06; 36(18):5393-401. PMID: 9154921.
      View in: PubMed
    122. Craig SP, Focia PJ, Fletterick RJ. Substitution of lysine for arginine at position 199 of a hypoxanthine phosphoribosyltransferase interferes with binding of the primary substrate to the active site. Biochim Biophys Acta. 1997 Apr 25; 1339(1):1-3. PMID: 9165092.
      View in: PubMed
    123. Collingwood TN, Rajanayagam O, Adams M, Wagner R, Cavaillès V, Kalkhoven E, Matthews C, Nystrom E, Stenlof K, Lindstedt G, Tisell L, Fletterick RJ, Parker MG, Chatterjee VK. A natural transactivation mutation in the thyroid hormone beta receptor: impaired interaction with putative transcriptional mediators. Proc Natl Acad Sci U S A. 1997 Jan 07; 94(1):248-53. PMID: 8990194; PMCID: PMC19304.
    124. Vale RD, Fletterick RJ. The design plan of kinesin motors. Annu Rev Cell Dev Biol. 1997; 13:745-77. PMID: 9442886.
      View in: PubMed
    125. Lin K, Rath VL, Dai SC, Fletterick RJ, Hwang PK. A protein phosphorylation switch at the conserved allosteric site in GP. Science. 1996 Sep 13; 273(5281):1539-42. PMID: 8703213.
      View in: PubMed
    126. Buchbinder JL, Fletterick RJ. Role of the active site gate of glycogen phosphorylase in allosteric inhibition and substrate binding. J Biol Chem. 1996 Sep 13; 271(37):22305-9. PMID: 8798388.
      View in: PubMed
    127. Li R, Chen X, Gong B, Selzer PM, Li Z, Davidson E, Kurzban G, Miller RE, Nuzum EO, McKerrow JH, Fletterick RJ, Gillmor SA, Craik CS, Kuntz ID, Cohen FE, Kenyon GL. Structure-based design of parasitic protease inhibitors. Bioorg Med Chem. 1996 Sep; 4(9):1421-7. PMID: 8894100.
      View in: PubMed
    128. Somoza JR, Chin MS, Focia PJ, Wang CC, Fletterick RJ. Crystal structure of the hypoxanthine-guanine-xanthine phosphoribosyltransferase from the protozoan parasite Tritrichomonas foetus. Biochemistry. 1996 Jun 04; 35(22):7032-40. PMID: 8679528.
      View in: PubMed
    129. Willett WS, Brinen LS, Fletterick RJ, Craik CS. Delocalizing trypsin specificity with metal activation. Biochemistry. 1996 May 14; 35(19):5992-8. PMID: 8634240.
      View in: PubMed
    130. Brinen LS, Willett WS, Craik CS, Fletterick RJ. X-ray structures of a designed binding site in trypsin show metal-dependent geometry. Biochemistry. 1996 May 14; 35(19):5999-6009. PMID: 8634241.
      View in: PubMed
    131. Mehlhorn I, Groth D, Stöckel J, Moffat B, Reilly D, Yansura D, Willett WS, Baldwin M, Fletterick R, Cohen FE, Vandlen R, Henner D, Prusiner SB. High-level expression and characterization of a purified 142-residue polypeptide of the prion protein. Biochemistry. 1996 Apr 30; 35(17):5528-37. PMID: 8611544.
      View in: PubMed
    132. Rath VL, Lin K, Hwang PK, Fletterick RJ. The evolution of an allosteric site in phosphorylase. Structure. 1996 Apr 15; 4(4):463-73. PMID: 8740368.
      View in: PubMed
    133. Kull FJ, Sablin EP, Lau R, Fletterick RJ, Vale RD. Crystal structure of the kinesin motor domain reveals a structural similarity to myosin. Nature. 1996 Apr 11; 380(6574):550-5. PMID: 8606779; PMCID: PMC2851642.
    134. Sablin EP, Kull FJ, Cooke R, Vale RD, Fletterick RJ. Crystal structure of the motor domain of the kinesin-related motor ncd. Nature. 1996 Apr 11; 380(6574):555-9. PMID: 8606780.
      View in: PubMed
    135. Wagner RL, Apriletti JW, McGrath ME, West BL, Baxter JD, Fletterick RJ. A structural role for hormone in the thyroid hormone receptor. Nature. 1995 Dec 14; 378(6558):690-7. PMID: 7501015.
      View in: PubMed
    136. Lin K, Hwang PK, Fletterick RJ. Mechanism of regulation in yeast glycogen phosphorylase. J Biol Chem. 1995 Nov 10; 270(45):26833-9. PMID: 7592925.
      View in: PubMed
    137. Shimizu T, Sablin E, Vale RD, Fletterick R, Pechatnikova E, Taylor EW. Expression, purification, ATPase properties, and microtubule-binding properties of the ncd motor domain. Biochemistry. 1995 Oct 10; 34(40):13259-66. PMID: 7548090.
      View in: PubMed
    138. Nguyen JT, Inouye H, Baldwin MA, Fletterick RJ, Cohen FE, Prusiner SB, Kirschner DA. X-ray diffraction of scrapie prion rods and PrP peptides. J Mol Biol. 1995 Sep 29; 252(4):412-22. PMID: 7563061.
      View in: PubMed
    139. Fletterick RJ, Bazan JF. When one and one are not two. Nat Struct Biol. 1995 Sep; 2(9):721-3. PMID: 7552738.
      View in: PubMed
    140. Hoenger A, Sablin EP, Vale RD, Fletterick RJ, Milligan RA. Three-dimensional structure of a tubulin-motor-protein complex. Nature. 1995 Jul 20; 376(6537):271-4. PMID: 7617040.
      View in: PubMed
    141. Ribeiro RC, Apriletti JW, West BL, Wagner RL, Fletterick RJ, Schaufele F, Baxter JD. The molecular biology of thyroid hormone action. Ann N Y Acad Sci. 1995 Jun 30; 758:366-89. PMID: 7625705.
      View in: PubMed
    142. Crerar MM, Karlsson O, Fletterick RJ, Hwang PK. Chimeric muscle and brain glycogen phosphorylases define protein domains governing isozyme-specific responses to allosteric activation. J Biol Chem. 1995 Jun 09; 270(23):13748-56. PMID: 7775430.
      View in: PubMed
    143. Buchbinder JL, Guinovart JJ, Fletterick RJ. Mutations in paired alpha-helices at the subunit interface of glycogen phosphorylase alter homotropic and heterotropic cooperativity. Biochemistry. 1995 May 16; 34(19):6423-32. PMID: 7756273.
      View in: PubMed
    144. Buchbinder JL, Witkowski A, Smith S, Fletterick RJ. Crystallization and preliminary diffraction studies of thioesterase II from rat mammary gland. Proteins. 1995 May; 22(1):73-5. PMID: 7675790.
      View in: PubMed
    145. McGrath ME, Eakin AE, Engel JC, McKerrow JH, Craik CS, Fletterick RJ. The crystal structure of cruzain: a therapeutic target for Chagas' disease. J Mol Biol. 1995 Mar 24; 247(2):251-9. PMID: 7707373.
      View in: PubMed
    146. Guo J, Huang W, Zhou GW, Fletterick RJ, Scanlan TS. Mechanistically different catalytic antibodies obtained from immunization with a single transition-state analog. Proc Natl Acad Sci U S A. 1995 Feb 28; 92(5):1694-8. PMID: 7878042; PMCID: PMC42586.
    147. Willett WS, Gillmor SA, Perona JJ, Fletterick RJ, Craik CS. Engineered metal regulation of trypsin specificity. Biochemistry. 1995 Feb 21; 34(7):2172-80. PMID: 7857928.
      View in: PubMed
    148. Perona JJ, Hedstrom L, Rutter WJ, Fletterick RJ. Structural origins of substrate discrimination in trypsin and chymotrypsin. Biochemistry. 1995 Feb 07; 34(5):1489-99. PMID: 7849008.
      View in: PubMed
    149. McGrath ME, Gillmor SA, Fletterick RJ. Ecotin: lessons on survival in a protease-filled world. Protein Sci. 1995 Feb; 4(2):141-8. PMID: 7757004; PMCID: PMC2143063.
    150. Sablin EP, Fletterick RJ. Crystallization and preliminary structural studies of the ncd motor domain. Proteins. 1995 Jan; 21(1):68-9. PMID: 7716170.
      View in: PubMed
    151. Rath VL, Fletterick RJ. Parallel evolution in two homologues of phosphorylase. Nat Struct Biol. 1994 Oct; 1(10):681-90. PMID: 7634071.
      View in: PubMed
    152. Zhou GW, Guo J, Huang W, Fletterick RJ, Scanlan TS. Crystal structure of a catalytic antibody with a serine protease active site. Science. 1994 Aug 19; 265(5175):1059-64. PMID: 8066444.
      View in: PubMed
    153. Guenot J, Fletterick RJ, Kollman PA. A negative electrostatic determinant mediates the association between the Escherichia coli trp repressor and its operator DNA. Protein Sci. 1994 Aug; 3(8):1276-85. PMID: 7987223; PMCID: PMC2142927.
    154. Huang Z, Gabriel JM, Baldwin MA, Fletterick RJ, Prusiner SB, Cohen FE. Proposed three-dimensional structure for the cellular prion protein. Proc Natl Acad Sci U S A. 1994 Jul 19; 91(15):7139-43. PMID: 7913747; PMCID: PMC44354.
    155. Browner MF, Hackos D, Fletterick R. Identification of the molecular trigger for allosteric activation in glycogen phosphorylase. Nat Struct Biol. 1994 May; 1(5):327-33. PMID: 7664039.
      View in: PubMed
    156. Cohen FE, Pan KM, Huang Z, Baldwin M, Fletterick RJ, Prusiner SB. Structural clues to prion replication. Science. 1994 Apr 22; 264(5158):530-1. PMID: 7909169.
      View in: PubMed
    157. McGrath ME, Erpel T, Bystroff C, Fletterick RJ. Macromolecular chelation as an improved mechanism of protease inhibition: structure of the ecotin-trypsin complex. EMBO J. 1994 Apr 01; 13(7):1502-7. PMID: 8156987; PMCID: PMC394978.
    158. Fletterick RJ, McGrath ME. Deconvoluting serpins. Nat Struct Biol. 1994 Apr; 1(4):201-3. PMID: 7656041.
      View in: PubMed
    159. Baldwin MA, Pan KM, Nguyen J, Huang Z, Groth D, Serban A, Gasset M, Mehlhorn I, Fletterick RJ, Cohen FE. Spectroscopic characterization of conformational differences between PrPC and PrPSc: an alpha-helix to beta-sheet transition. Philos Trans R Soc Lond B Biol Sci. 1994 Mar 29; 343(1306):435-41. PMID: 7913763.
      View in: PubMed
    160. McGrath ME, Wagner RL, Apriletti JW, West BL, Ramalingam V, Baxter JD, Fletterick RJ. Preliminary crystallographic studies of the ligand-binding domain of the thyroid hormone receptor complexed with triiodothyronine. J Mol Biol. 1994 Mar 25; 237(2):236-9. PMID: 8126736.
      View in: PubMed
    161. Perona JJ, Hedstrom L, Wagner RL, Rutter WJ, Craik CS, Fletterick RJ. Exogenous acetate reconstitutes the enzymatic activity of trypsin Asp189Ser. Biochemistry. 1994 Mar 22; 33(11):3252-9. PMID: 8136360.
      View in: PubMed
    162. Pan KM, Baldwin M, Nguyen J, Gasset M, Serban A, Groth D, Mehlhorn I, Huang Z, Fletterick RJ, Cohen FE. Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins. Proc Natl Acad Sci U S A. 1993 Dec 01; 90(23):10962-6. PMID: 7902575; PMCID: PMC47901.
    163. Baker D, Bystroff C, Fletterick RJ, Agard DA. PRISM: topologically constrained phased refinement for macromolecular crystallography. Acta Crystallogr D Biol Crystallogr. 1993 Sep 01; 49(Pt 5):429-39. PMID: 15299502.
      View in: PubMed
    164. Bystroff C, Baker D, Fletterick RJ, Agard DA. PRISM: application to the solution of two protein structures. Acta Crystallogr D Biol Crystallogr. 1993 Sep 01; 49(Pt 5):440-8. PMID: 15299503.
      View in: PubMed
    165. Perona JJ, Craik CS, Fletterick RJ. Locating the catalytic water molecule in serine proteases. Science. 1993 Jul 30; 261(5121):620-2. PMID: 8342029.
      View in: PubMed
    166. Perona JJ, Tsu CA, Craik CS, Fletterick RJ. Crystal structures of rat anionic trypsin complexed with the protein inhibitors APPI and BPTI. J Mol Biol. 1993 Apr 05; 230(3):919-33. PMID: 7683059.
      View in: PubMed
    167. Perona JJ, Tsu CA, McGrath ME, Craik CS, Fletterick RJ. Relocating a negative charge in the binding pocket of trypsin. J Mol Biol. 1993 Apr 05; 230(3):934-49. PMID: 8478942.
      View in: PubMed
    168. Eakin AE, McGrath ME, McKerrow JH, Fletterick RJ, Craik CS. Production of crystallizable cruzain, the major cysteine protease from Trypanosoma cruzi. J Biol Chem. 1993 Mar 25; 268(9):6115-8. PMID: 8454586.
      View in: PubMed
    169. McGrath ME, Haymore BL, Summers NL, Craik CS, Fletterick RJ. Structure of an engineered, metal-actuated switch in trypsin. Biochemistry. 1993 Mar 02; 32(8):1914-9. PMID: 8448149.
      View in: PubMed
    170. Gasset M, Baldwin MA, Fletterick RJ, Prusiner SB. Perturbation of the secondary structure of the scrapie prion protein under conditions that alter infectivity. Proc Natl Acad Sci U S A. 1993 Jan 01; 90(1):1-5. PMID: 8419912; PMCID: PMC45587.
    171. Luong CB, Browner MF, Fletterick R, Haymore BL. Purification of glycogen phosphorylase isozymes by metal-affinity chromatography. J Chromatogr. 1992 Dec 11; 584(1):77-84. PMID: 1487518.
      View in: PubMed
    172. Browner MF, Fauman EB, Fletterick R. Tracking conformational states in allosteric transitions of phosphorylase. Biochemistry. 1992 Nov 24; 31(46):11297-304. PMID: 1445867.
      View in: PubMed
    173. Browner MF, Hwang PK, Fletterick R. Cooperative binding is not required for activation of muscle phosphorylase. Biochemistry. 1992 Nov 24; 31(46):11291-6. PMID: 1445866.
      View in: PubMed
    174. Goddette DW, Paech C, Yang SS, Mielenz JR, Bystroff C, Wilke ME, Fletterick R. The crystal structure of the Bacillus lentus alkaline protease, subtilisin BL, at 1.4 A resolution. J Mol Biol. 1992 Nov 20; 228(2):580-95. PMID: 1453465.
      View in: PubMed
    175. Gasset M, Baldwin MA, Lloyd DH, Gabriel JM, Holtzman DM, Cohen F, Fletterick R, Prusiner SB. Predicted alpha-helical regions of the prion protein when synthesized as peptides form amyloid. Proc Natl Acad Sci U S A. 1992 Nov 15; 89(22):10940-4. PMID: 1438300; PMCID: PMC50458.
    176. Rath VL, Hwang PK, Fletterick R. Purification and crystallization of glycogen phosphorylase from Saccharomyces cerevisiae. J Mol Biol. 1992 Jun 20; 225(4):1027-34. PMID: 1613787.
      View in: PubMed
    177. McGrath ME, Vásquez JR, Craik CS, Yang AS, Honig B, Fletterick R. Perturbing the polar environment of Asp102 in trypsin: consequences of replacing conserved Ser214. Biochemistry. 1992 Mar 31; 31(12):3059-64. PMID: 1554694.
      View in: PubMed
    178. Erpel T, Hwang P, Craik CS, Fletterick R, McGrath ME. Physical map location of the new Escherichia coli gene eco, encoding the serine protease inhibitor ecotin. J Bacteriol. 1992 Mar; 174(5):1704. PMID: 1537814; PMCID: PMC206573.
    179. Higaki JN, Fletterick R, Craik CS. Engineered metalloregulation in enzymes. Trends Biochem Sci. 1992 Mar; 17(3):100-4. PMID: 1329276.
      View in: PubMed
    180. Browner MF, Fletterick R. Phosphorylase: a biological transducer. Trends Biochem Sci. 1992 Feb; 17(2):66-71. PMID: 1566331.
      View in: PubMed
    181. Sprang SR, Withers SG, Goldsmith EJ, Fletterick R, Madsen NB. Structural basis for the activation of glycogen phosphorylase b by adenosine monophosphate. Science. 1991 Nov 29; 254(5036):1367-71. PMID: 1962195.
      View in: PubMed
    182. McGrath ME, Erpel T, Browner MF, Fletterick R. Expression of the protease inhibitor ecotin and its co-crystallization with trypsin. J Mol Biol. 1991 Nov 20; 222(2):139-42. PMID: 1960717.
      View in: PubMed
    183. Coats WS, Browner MF, Fletterick R, Newgard CB. An engineered liver glycogen phosphorylase with AMP allosteric activation. J Biol Chem. 1991 Aug 25; 266(24):16113-9. PMID: 1874749.
      View in: PubMed
    184. Wilke ME, Higaki JN, Craik CS, Fletterick R. Crystal structure of rat trypsin-S195C at -150 degrees C. Analysis of low activity of recombinant and semisynthetic thiol proteases. J Mol Biol. 1991 Jun 05; 219(3):511-23. PMID: 1904942.
      View in: PubMed
    185. Wilke ME, Higaki JN, Craik CS, Fletterick R. Crystallographic analysis of trypsin-G226A. A specificity pocket mutant of rat trypsin with altered binding and catalysis. J Mol Biol. 1991 Jun 05; 219(3):525-32. PMID: 2051486.
      View in: PubMed
    186. McGrath ME, Hines WM, Sakanari JA, Fletterick R, Craik CS. The sequence and reactive site of ecotin. A general inhibitor of pancreatic serine proteases from Escherichia coli. J Biol Chem. 1991 Apr 05; 266(10):6620-5. PMID: 2007606.
      View in: PubMed
    187. Browner MF, Rasor P, Tugendreich S, Fletterick R. Temperature-sensitive production of rabbit muscle glycogen phosphorylase in Escherichia coli. Protein Eng. 1991 Feb; 4(3):351-7. PMID: 1857717.
      View in: PubMed
    188. Gregoret LM, Rader SD, Fletterick R, Cohen FE. Hydrogen bonds involving sulfur atoms in proteins. Proteins. 1991; 9(2):99-107. PMID: 1755867.
      View in: PubMed
    189. Sloane DL, Browner MF, Dauter Z, Wilson K, Fletterick R, Sigal E. Purification and crystallization of 15-lipoxygenase from rabbit reticulocytes. Biochem Biophys Res Commun. 1990 Dec 14; 173(2):507-13. PMID: 2260964.
      View in: PubMed
    190. Phillips MA, Fletterick R, Rutter WJ. Arginine 127 stabilizes the transition state in carboxypeptidase. J Biol Chem. 1990 Nov 25; 265(33):20692-8. PMID: 2243116.
      View in: PubMed
    191. Lebo RV, Anderson LA, DiMauro S, Lynch E, Hwang P, Fletterick R. Rare McArdle disease locus polymorphic site on 11q13 contains CpG sequence. Hum Genet. 1990 Nov; 86(1):17-24. PMID: 1701414.
      View in: PubMed
    192. Chambers TJ, Weir RC, Grakoui A, McCourt DW, Bazan JF, Fletterick R, Rice CM. Evidence that the N-terminal domain of nonstructural protein NS3 from yellow fever virus is a serine protease responsible for site-specific cleavages in the viral polyprotein. Proc Natl Acad Sci U S A. 1990 Nov; 87(22):8898-902. PMID: 2147282; PMCID: PMC55067.
    193. Higaki JN, Haymore BL, Chen S, Fletterick R, Craik CS. Regulation of serine protease activity by an engineered metal switch. Biochemistry. 1990 Sep 18; 29(37):8582-6. PMID: 2125468.
      View in: PubMed
    194. Soman K, Yang AS, Honig B, Fletterick R. Electrical potentials in trypsin isozymes. Biochemistry. 1989 Dec 26; 28(26):9918-26. PMID: 2695163.
      View in: PubMed
    195. Bazan JF, Fletterick R, Pilkis SJ. Evolution of a bifunctional enzyme: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. Proc Natl Acad Sci U S A. 1989 Dec; 86(24):9642-6. PMID: 2557623; PMCID: PMC298557.
    196. McGrath ME, Wilke ME, Higaki JN, Craik CS, Fletterick R. Crystal structures of two engineered thiol trypsins. Biochemistry. 1989 Nov 28; 28(24):9264-70. PMID: 2611228.
      View in: PubMed
    197. Zhang WM, Browner MF, Fletterick RJ, DePaoli-Roach AA, Roach PJ. Primary structure of rabbit skeletal muscle glycogen synthase deduced from cDNA clones. FASEB J. 1989 Nov; 3(13):2532-6. PMID: 2509275.
      View in: PubMed
    198. Dougherty WG, Parks TD, Cary SM, Bazan JF, Fletterick R. Characterization of the catalytic residues of the tobacco etch virus 49-kDa proteinase. Virology. 1989 Sep; 172(1):302-10. PMID: 2475971.
      View in: PubMed
    199. Goldsmith EJ, Sprang SR, Hamlin R, Xuong NH, Fletterick R. Domain separation in the activation of glycogen phosphorylase a. Science. 1989 Aug 04; 245(4917):528-32. PMID: 2756432.
      View in: PubMed
    200. Bazan JF, Fletterick R. Detection of a trypsin-like serine protease domain in flaviviruses and pestiviruses. Virology. 1989 Aug; 171(2):637-9. PMID: 2548336.
      View in: PubMed
    201. Bazan JF, Fletterick R. Comparative analysis of viral cysteine protease structural models. FEBS Lett. 1989 May 22; 249(1):5-7. PMID: 2721688.
      View in: PubMed
    202. Hwang PK, Tugendreich S, Fletterick RJ. Molecular analysis of GPH1, the gene encoding glycogen phosphorylase in Saccharomyces cerevisiae. Mol Cell Biol. 1989 Apr; 9(4):1659-66. PMID: 2657401; PMCID: PMC362584.
    203. McGrath ME, Fletterick R, Craik CS. Rapid preparation of proteins for crystallization trials. Biotechniques. 1989 Mar; 7(3):246-7. PMID: 2631770.
      View in: PubMed
    204. Browner MF, Nakano K, Bang AG, Fletterick R. Human muscle glycogen synthase cDNA sequence: a negatively charged protein with an asymmetric charge distribution. Proc Natl Acad Sci U S A. 1989 Mar; 86(5):1443-7. PMID: 2493642; PMCID: PMC286712.
    205. Newgard CB, Hwang PK, Fletterick R. The family of glycogen phosphorylases: structure and function. Crit Rev Biochem Mol Biol. 1989; 24(1):69-99. PMID: 2667896.
      View in: PubMed
    206. Servidei S, Shanske S, Zeviani M, Lebo R, Fletterick R, DiMauro S. McArdle's disease: biochemical and molecular genetic studies. Ann Neurol. 1988 Dec; 24(6):774-81. PMID: 3207360.
      View in: PubMed
    207. Sprang SR, Acharya KR, Goldsmith EJ, Stuart DI, Varvill K, Fletterick R, Madsen NB, Johnson LN. Structural changes in glycogen phosphorylase induced by phosphorylation. Nature. 1988 Nov 17; 336(6196):215-21. PMID: 3194008.
      View in: PubMed
    208. Bazan JF, Fletterick R. Viral cysteine proteases are homologous to the trypsin-like family of serine proteases: structural and functional implications. Proc Natl Acad Sci U S A. 1988 Nov; 85(21):7872-6. PMID: 3186696; PMCID: PMC282299.
    209. Newgard CB, Littman DR, van Genderen C, Smith M, Fletterick RJ. Human brain glycogen phosphorylase. Cloning, sequence analysis, chromosomal mapping, tissue expression, and comparison with the human liver and muscle isozymes. J Biol Chem. 1988 Mar 15; 263(8):3850-7. PMID: 3346228.
      View in: PubMed
    210. Sprang SR, Fletterick R, Gráf L, Rutter WJ, Craik CS. Studies of specificity and catalysis in trypsin by structural analysis of site-directed mutants. Crit Rev Biotechnol. 1988; 8(3):225-36. PMID: 3063392.
      View in: PubMed
    211. Braun MJ, Gonda MA, George DG, Bazan JF, Fletterick RJ, Prusiner SB. The burden of proof in linking AIDS to scrapie. Nature. 1987 Dec 10-16; 330(6148):525-6. PMID: 2891035.
      View in: PubMed
    212. Pastuszyn A, Noland BJ, Bazan JF, Fletterick R, Scallen TJ. Primary sequence and structural analysis of sterol carrier protein 2 from rat liver: homology with immunoglobulins. J Biol Chem. 1987 Sep 25; 262(27):13219-27. PMID: 3115977.
      View in: PubMed
    213. Sprang S, Goldsmith E, Fletterick R. Structure of the nucleotide activation switch in glycogen phosphorylase a. Science. 1987 Aug 28; 237(4818):1012-9. PMID: 3616621.
      View in: PubMed
    214. Sprang S, Standing T, Fletterick R, Stroud RM, Finer-Moore J, Xuong NH, Hamlin R, Rutter WJ, Craik CS. The three-dimensional structure of Asn102 mutant of trypsin: role of Asp102 in serine protease catalysis. Science. 1987 Aug 21; 237(4817):905-9. PMID: 3112942.
      View in: PubMed
    215. Graf L, Craik CS, Patthy A, Roczniak S, Fletterick R, Rutter WJ. Selective alteration of substrate specificity by replacement of aspartic acid-189 with lysine in the binding pocket of trypsin. Biochemistry. 1987 May 05; 26(9):2616-23. PMID: 3111531.
      View in: PubMed
    216. Newgard CB, Fletterick R, Anderson LA, Lebo RV. The polymorphic locus for glycogen storage disease VI (liver glycogen phosphorylase) maps to chromosome 14. Am J Hum Genet. 1987 Apr; 40(4):351-64. PMID: 2883891; PMCID: PMC1684093.
    217. Craik CS, Roczniak S, Sprang S, Fletterick R, Rutter W. Redesigning trypsin via genetic engineering. J Cell Biochem. 1987 Mar; 33(3):199-211. PMID: 3553217.
      View in: PubMed
    218. Goldsmith EJ, Fletterick RJ, Withers SG. The three-dimensional structure of acarbose bound to glycogen phosphorylase. J Biol Chem. 1987 Feb 05; 262(4):1449-55. PMID: 3805034.
      View in: PubMed
    219. Fernando Bazan J, Fletterick R, Prusiner SB. AIDS virus and scrapie protein genes. Nature. 1987 Feb 12-18; 325(6105):581. PMID: 3100963.
      View in: PubMed
    220. Bazan JF, Fletterick R, McKinley MP, Prusiner SB. Predicted secondary structure and membrane topology of the scrapie prion protein. Protein Eng. 1987 Feb-Mar; 1(2):125-35. PMID: 2907134.
      View in: PubMed
    221. Burke J, Hwang P, Anderson L, Lebo R, Gorin F, Fletterick R. Intron/exon structure of the human gene for the muscle isozyme of glycogen phosphorylase. Proteins. 1987; 2(3):177-87. PMID: 3447177.
      View in: PubMed
    222. Rath VL, Newgard CB, Sprang SR, Goldsmith EJ, Fletterick RJ. Modeling the biochemical differences between rabbit muscle and human liver phosphorylase. Proteins. 1987; 2(3):225-35. PMID: 3447179.
      View in: PubMed
    223. Hwang PK, Fletterick RJ. Convergent and divergent evolution of regulatory sites in eukaryotic phosphorylases. Nature. 1986 Nov 6-12; 324(6092):80-4. PMID: 3537803.
      View in: PubMed
    224. Newgard CB, Nakano K, Hwang PK, Fletterick R. Sequence analysis of the cDNA encoding human liver glycogen phosphorylase reveals tissue-specific codon usage. Proc Natl Acad Sci U S A. 1986 Nov; 83(21):8132-6. PMID: 2877458; PMCID: PMC386881.
    225. Nakano K, Hwang PK, Fletterick R. Complete cDNA sequence for rabbit muscle glycogen phosphorylase. FEBS Lett. 1986 Aug 18; 204(2):283-7. PMID: 3015680.
      View in: PubMed
    226. Cohen FE, Abarbanel RM, Kuntz ID, Fletterick RJ. Turn prediction in proteins using a pattern-matching approach. Biochemistry. 1986 Jan 14; 25(1):266-75. PMID: 3754149.
      View in: PubMed
    227. Fletterick RJ, Burke JA, Hwang PK, Nakano K, Newgard CB. Structural relationships in glycogen phosphorylases. Ann N Y Acad Sci. 1986; 478:220-32. PMID: 3541750.
      View in: PubMed
    228. Hwang PK, See YP, Vincentini AM, Powers MA, Fletterick RJ, Crerar MM. Comparative sequence analysis of rat, rabbit, and human muscle glycogen phosphorylase cDNAs. Eur J Biochem. 1985 Oct 15; 152(2):267-74. PMID: 3840433.
      View in: PubMed
    229. Craik CS, Largman C, Fletcher T, Roczniak S, Barr PJ, Fletterick R, Rutter WJ. Redesigning trypsin: alteration of substrate specificity. Science. 1985 Apr 19; 228(4697):291-7. PMID: 3838593.
      View in: PubMed
    230. Fletterick RJ, Sygusch J. Measuring X-ray diffraction data from large proteins with X-ray diffractometry. Methods Enzymol. 1985; 114:386-97. PMID: 4079773.
      View in: PubMed
    231. Hwang P, Stern M, Fletterick RJ. Purification and crystallization of bovine liver phosphorylase. Biochim Biophys Acta. 1984 Dec 07; 791(2):252-8. PMID: 6509068.
      View in: PubMed
    232. Lebo RV, Gorin F, Fletterick RJ, Kao FT, Cheung MC, Bruce BD, Kan YW. High-resolution chromosome sorting and DNA spot-blot analysis assign McArdle's syndrome to chromosome 11. Science. 1984 Jul 06; 225(4657):57-9. PMID: 6587566.
      View in: PubMed
    233. Thaller C, Alberts B, Goldsmith E, Sprang S, Fletterick R. Crystallization of the gene 45 protein from the DNA replication fork of bacteriophage T4. J Biol Chem. 1984 Feb 25; 259(4):2568-9. PMID: 6365913.
      View in: PubMed
    234. Cohen FE, Abarbanel RM, Kuntz ID, Fletterick RJ. Secondary structure assignment for alpha/beta proteins by a combinatorial approach. Biochemistry. 1983 Oct 11; 22(21):4894-904. PMID: 6639935.
      View in: PubMed
    235. Madsen NB, Shechosky S, Fletterick RJ. Site-site interactions in glycogen phosphorylase b probed by ligands specific for each site. Biochemistry. 1983 Sep 13; 22(19):4460-5. PMID: 6414512.
      View in: PubMed
    236. Craik CS, Rutter WJ, Fletterick R. Splice junctions: association with variation in protein structure. Science. 1983 Jun 10; 220(4602):1125-9. PMID: 6344214.
      View in: PubMed
    237. Sprang SR, Goldsmith EJ, Fletterick RJ, Withers SG, Madsen NB. Catalytic site of glycogen phosphorylase: structure of the T state and specificity for alpha-D-glucose. Biochemistry. 1982 Oct 12; 21(21):5364-71. PMID: 6816272.
      View in: PubMed
    238. Withers SG, Madsen NB, Sprang SR, Fletterick RJ. Catalytic site of glycogen phosphorylase: structural changes during activation and mechanistic implications. Biochemistry. 1982 Oct 12; 21(21):5372-82. PMID: 7171564.
      View in: PubMed
    239. Craik CS, Sprang S, Fletterick R, Rutter WJ. Intron-exon splice junctions map at protein surfaces. Nature. 1982 Sep 09; 299(5879):180-2. PMID: 7110339.
      View in: PubMed
    240. Sprang S, Fletterick R, Stern M, Yang D, Madsen N, Sturtevant J. Analysis of an allosteric binding site: the nucleoside inhibitor site of phosphorylase alpha. Biochemistry. 1982 Apr 27; 21(9):2036-48. PMID: 7093228.
      View in: PubMed
    241. Goldsmith E, Sprang S, Fletterick R. Structure of maltoheptaose by difference Fourier methods and a model for glycogen. J Mol Biol. 1982 Apr 05; 156(2):411-27. PMID: 7086906.
      View in: PubMed
    242. Kasvinsky PJ, Fletterick RJ, Madsen NB. Regulation of the dephosphorylation of glycogen phosphorylase a and synthase b by glucose and caffeine in isolated hepatocytes. Can J Biochem. 1981 Jun; 59(6):387-95. PMID: 6794883.
      View in: PubMed
    243. Sprang S, Fletterick RJ. Subunit interactions and the allosteric response in phosphorylase. Biophys J. 1980 Oct; 32(1):175-92. PMID: 6788104; PMCID: PMC1327277.
    244. Matela RJ, Fletterick RJ. Computer simulation of cellular self-sorting: a topological exchange model. J Theor Biol. 1980 Jun 21; 84(4):673-90. PMID: 7431947.
      View in: PubMed
    245. Fletterick RJ, Madsen NB. The structures and related functions of phosphorylase a. Annu Rev Biochem. 1980; 49:31-61. PMID: 6996565.
      View in: PubMed
    246. Sprang S, Yang D, Fletterick R. Solvent accessibility properties of complex proteins. Nature. 1979 Jul 26; 280(5720):333-5. PMID: 460408.
      View in: PubMed
    247. Sprang S, Fletterick R. The structure of glycogen phosphorylase alpha at 2.5 A resolution. J Mol Biol. 1979 Jul 05; 131(3):523-51. PMID: 513128.
      View in: PubMed
    248. Fletterick R, Sprang S, Madsen NB. Analysis of the surface topography of glycogen phosphorylase a: implications for metabolic interconversion and regulatory mechanisms. Can J Biochem. 1979 Jun; 57(6):789-97. PMID: 476522.
      View in: PubMed
    249. Withers SG, Yang DS, Madsen NB, Fletterick R. A systematic approach to isomorphous replacement using a series of simple charged mercurials. Biochem Biophys Res Commun. 1979 Feb 28; 86(4):1044-50. PMID: 435308.
      View in: PubMed
    250. Matela RJ, Fletterick R. A topological exchange model for cell self-sorting. J Theor Biol. 1979 Feb 21; 76(4):403-14. PMID: 439912.
      View in: PubMed
    251. Sprang S, Fletterick R. Crystallographic analysis of phosphorylase alpha at 2.5 A resolution, a comment on the chemical sequence. Biochemistry. 1978 Dec 26; 17(26):5693-4. PMID: 728427.
      View in: PubMed
    252. Kasvinsky PJ, Shechosky S, Fletterick R. Synergistic regulation of phosphorylase a by glucose and caffeine. J Biol Chem. 1978 Dec 25; 253(24):9102-6. PMID: 721834.
      View in: PubMed
    253. Madsen NB, Fletterick R. Allosteric transitions of phosphorylase a and the regulation of glycogen metabolism. J Biol Chem. 1978 Dec 25; 253(24):9097-101. PMID: 721833.
      View in: PubMed
    254. Kasvinsky PJ, Madsen NB, Sygusch J, Fletterick R. The regulation of glycogen phosphorylase alpha by nucleotide derivatives. Kinetic and x-ray crystallographic studies. J Biol Chem. 1978 May 10; 253(9):3343-51. PMID: 641070.
      View in: PubMed
    255. Kasvinsky PJ, Madsen NB, Fletterick R, Sygusch J. X-ray crystallographic and kinetic studies of oligosaccharide binding to phosphorylase. J Biol Chem. 1978 Feb 25; 253(4):1290-6. PMID: 624732.
      View in: PubMed
    256. Sygusch J, Madsen NB, Kasvinsky PJ, Fletterick R. Location of pyridoxal phosphate in glycogen phosphorylase a. Proc Natl Acad Sci U S A. 1977 Nov; 74(11):4757-61. PMID: 270710; PMCID: PMC432034.
    257. Steitz TA, Anderson WF, Fletterick RJ, Anderson CM. High resolution crystal structures of yeast hexokinase complexes with substrates, activators, and inhibitors. Evidence for an allosteric control site. J Biol Chem. 1977 Jul 10; 252(13):4494-500. PMID: 326777.
      View in: PubMed
    258. Li EC, Fletterick R, Sygusch J, Madsen NB. An essential arginine residue in the active-site pocket of glycogen phosporylase. Can J Biochem. 1977 Apr; 55(4):465-73. PMID: 870152.
      View in: PubMed
    259. Fletterick R, Sygusch J, Semple H, Madsen NB. Structure of glycogen phosphorylase a at 3.0 A resolution and its ligand binding sites at 6 A. J Biol Chem. 1976 Oct 10; 251(19):6142-6. PMID: 184094.
      View in: PubMed
    260. Steitz TA, Fletterick RJ, Anderson WF, Anderson CM. High resolution x-ray structure of yeast hexokinase, an allosteric protein exhibiting a non-symmetric arrangement of subunits. J Mol Biol. 1976 Jun 14; 104(1):197-22. PMID: 785010.
      View in: PubMed
    261. Fletterick R, Sygusch J, Murray N, Madsen NB. Low-resolution structure of the glycogen phosphorylase alpha monomer and comparison with phosphorylase beta. J Mol Biol. 1976 May 05; 103(1):1-13. PMID: 957422.
      View in: PubMed
    262. Fletterick R, Bates DJ, Steitz TA. The structure of a yeast hexokinase monomer and its complexes with substrates at 2.7-A resolution. Proc Natl Acad Sci U S A. 1975 Jan; 72(1):38-42. PMID: 164023; PMCID: PMC432235.
    263. Anderson WF, Fletterick RJ, Steitz TA. Structure of yeast hexokinase. 3. Low resolution structure of a second crystal form showing a different quaternary structure, heterologous interaction of subunits and substrate binding. J Mol Biol. 1974 Jun 25; 86(2):261-9. PMID: 4370398.
      View in: PubMed
    264. Steitz TA, Fletterick RJ, Hwang KJ. Structure of yeast hexokinase. II. A 6 angstrom resolution electron density map showing molecular shape and heterologous interaction of subunits. J Mol Biol. 1973 Aug 15; 78(3):551-61. PMID: 4585329.
      View in: PubMed
    265. Fletterick RJ, Tsai C, Hughes RE. The crystal and molecular structure of L-alanyl-L-alanine. J Phys Chem. 1971 Apr 01; 75(7):918-22. PMID: 5135343.
      View in: PubMed
    266. Fletterick RJ, Tsai CC, Hughes RE. The crystal and molecular structure of L-alanyl-L-alanine. J Phys Chem. 1971 Apr 01; 75(7):918-22. PMID: 5552704.
      View in: PubMed
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