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    Elliot Stieglitz, MD

    TitleAssistant Professor
    SchoolUCSF School of Medicine
    DepartmentPediatrics
    Address1450 Third St
    San Francisco CA 94158
    Phone415-514-9389
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      Collapse Biography 
      Collapse Education and Training
      Stony Brook School of Medicine2008
      New York Presbyterian - Weill CornellPediatric Residency2011
      University of California, San FranciscoPediatric Hematology Oncology Fellowship2014
      Collapse Awards and Honors
      St. Baldrick's Foundation Fellowship2014 - 2016Fellow in Clinical Research
      Alex's Lemonade Stand Foundation2015 - 2017Young Investigator Award
      American Cancer Society2016 - 2017Individual Research Award
      ASH/EHA2016 - 2016Translational Research Training in Hematology

      Collapse Overview 
      Collapse Overview
      Juvenile myelomonocytic leukemia (JMML) is a blood cancer that affects young children and is often difficult to diagnose and treat. Currently available therapies cure only half of patients, with some children experiencing an aggressive disease course while a rare group get better with very little treatment. Unfortunately, we are currently unable to identify these patients at diagnosis.

      My first objective is to identify biomarkers associated with a poor prognosis in order to establish a risk stratification algorithm that will prevent using toxic chemotherapy in patients who are predicted not to respond. I am using several next generation sequencing techniques in order to identify these biomarkers including exome sequencing, DNA methylation analysis and droplet digital PCR. Second, with specific biomarkers in place, I can identify targeted medications that would be predicted to improve outcomes for these patients.


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      Collapse Featured Publications

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Ceremsak JJ, Yu A, Esquivel E, Lissewski C, Zenker M, Loh ML, Stieglitz E. Germline RRAS2 mutations are not associated with Noonan syndrome. J Med Genet. 2016 Apr 7. PMID: 27055474.
        View in: PubMed
      2. Stieglitz E, Loh ML. Pediatric MDS: GATA screen the germline. Blood. 2016 Mar 17; 127(11):1377-8. PMID: 26989184.
        View in: PubMed
      3. Stieglitz E, Taylor-Weiner AN, Chang TY, Gelston LC, Wang YD, Mazor T, Esquivel E, Yu A, Seepo S, Olsen SR, Rosenberg M, Archambeault SL, Abusin G, Beckman K, Brown PA, Briones M, Carcamo B, Cooper T, Dahl GV, Emanuel PD, Fluchel MN, Goyal RK, Hayashi RJ, Hitzler J, Hugge C, Liu YL, Messinger YH, Mahoney DH, Monteleone P, Nemecek ER, Roehrs PA, Schore RJ, Stine KC, Takemoto CM, Toretsky JA, Costello JF, Olshen AB, Stewart C, Li Y, Ma J, Gerbing RB, Alonzo TA, Getz G, Gruber TA, Golub TR, Stegmaier K, Loh ML. The genomic landscape of juvenile myelomonocytic leukemia. Nat Genet. 2015 Nov; 47(11):1326-33. PMID: 26457647; PMCID: PMC4626387 [Available on 05/01/16].
      4. Stieglitz E, Ward AF, Gerbing RB, Alonzo TA, Arceci RJ, Liu YL, Emanuel PD, Widemann BC, Cheng JW, Jayaprakash N, Balis FM, Castleberry RP, Bunin NJ, Loh ML, Cooper TM. Phase II/III trial of a pre-transplant farnesyl transferase inhibitor in juvenile myelomonocytic leukemia: a report from the Children's Oncology Group. Pediatr Blood Cancer. 2015 Apr; 62(4):629-36. PMID: 25704135; PMCID: PMC4339233 [Available on 04/01/16].
      5. Stieglitz E, Troup CB, Gelston LC, Haliburton J, Chow ED, Yu KB, Akutagawa J, Taylor-Weiner AN, Liu YL, Wang YD, Beckman K, Emanuel PD, Braun BS, Abate A, Gerbing RB, Alonzo TA, Loh ML. Subclonal mutations in SETBP1 confer a poor prognosis in juvenile myelomonocytic leukemia. Blood. 2015 Jan 15; 125(3):516-24. PMID: 25395418; PMCID: PMC4296011 [Available on 01/15/16].
      6. Stieglitz E, Liu YL, Emanuel PD, Castleberry RP, Cooper TM, Shannon KM, Loh ML. Mutations in GATA2 are rare in juvenile myelomonocytic leukemia. Blood. 2014 Feb 27; 123(9):1426-7. PMID: 24578498; PMCID: PMC3938154.
      7. Stieglitz E, Hsiang MS, Simko JP, Hirose S, Goldsby RE. Pulmonary coccidiomycosis masquerading as refractory metastatic Ewing sarcoma. J Pediatr Hematol Oncol. 2014 Jan; 36(1):e57-60. PMID: 23588326.
        View in: PubMed
      8. Stieglitz E, Loh ML. Genetic predispositions to childhood leukemia. Ther Adv Hematol. 2013 Aug; 4(4):270-90. PMID: 23926459; PMCID: PMC3734905.
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