Natasha Spottiswoode, MD, PhD
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Title(s) | Assistant Professor, Medicine |
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School | School of Medicine |
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Address | 513 Parnassus Avenue, HSE, #380 San Francisco CA 94143
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Phone | 415-353-7900 |
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ORCID
| 0000-0001-6157-3716 |
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vCard | Download vCard |
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Biography
California State University Los Angeles , Los Angeles, CA | BS | 06/2018 | Biology |
University of Oxford, UK | BSc | 09/2010 | Integrative Bioscience |
University of Oxford/National Institutes of Health, UK/Maryland | DPhil | 06/2014 | Biomedical Sciences |
Columbia University Vagelos College of Physicians and Surgeons, New York | MD | 05/2018 | Medicine |
University of California San Francisco Medical Center, San Francisco | | 06/2021 | Medicine Residency |
University of California San Francisco, San Francisco | | | Infectious Disease Fellowship |
Center for Pandemic Preparedness Response | 2023
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| 2024 | CPPR Investigator Seed Award |
NIPLH | 2022
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| 2023 | Nina Ireland Award |
Centers for Disease Control and Prevention | 2020 | | David J Sencer Scholarship |
Department of Medicine, UCSF | 2020 | | Poetry Award |
Infectious Disease Week | 2022 | | Travel Bursary |
Overview
Infectious disease physician-scientist with a focused on unbiased diagnostics and developing treatments for uncommon infections.
Featured Content
Bibliographic
Altmetrics Details
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media.
(Note that publications are often cited in additional ways that are not shown here.)
Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication.
Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication.
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Rewriting the Script. Clin Infect Dis. 2024 Nov 27.
Spottiswoode N, Minter DJ, Friedman-Moraco R. PMID: 39600205.
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PubMed Mentions:
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Microbial dynamics and pulmonary immune responses in COVID-19 secondary bacterial pneumonia. Nat Commun. 2024 Oct 29; 15(1):9339.
Spottiswoode N, Tsitsiklis A, Chu VT, Phan HV, DeVoe C, Love C, Ghale R, Bloomstein J, Zha BS, Maguire CP, Glascock A, Sarma A, Mourani PM, Kalantar KL, Detweiler A, Neff N, Haller SC, COMET Consortium, DeRisi JL, Erle DJ, Hendrickson CM, Kangelaris KN, Krummel MF, Matthay MA, Woodruff PG, Calfee CS, Langelier CR. PMID: 39472555; PMCID: PMC11522429.
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PubMed Mentions: Fields:
Translation:
HumansCells
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Pulmonary FABP4 Is an Inverse Biomarker of Pneumonia in Critically Ill Children and Adults. Am J Respir Crit Care Med. 2024 Sep 23.
Lydon EC, Phan HV, Mick E, Spottiswoode N, Calfee CS, Mourani PM, Langelier CR. PMID: 39312201.
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PubMed Mentions: Fields:
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Advancing Sepsis Endotyping Globally: Lessons From a Prospective Study in Uganda. Crit Care Med. 2024 03 01; 52(3):515-517.
Neyton L, Spottiswoode N. PMID: 38381016; PMCID: PMC10883597.
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Translation:
Humans
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Challenges and advances in the medical treatment of granulomatous amebic encephalitis. Ther Adv Infect Dis. 2024 Jan-Dec; 11:20499361241228340.
Spottiswoode N, Haston JC, Hanners NW, Gruenberg K, Kim A, DeRisi JL, Wilson MR. PMID: 38312848; PMCID: PMC10838035.
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PubMed Mentions:
1
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In host evolution of beta lactam resistance during active treatment for Pseudomonas aeruginosa bacteremia. Front Cell Infect Microbiol. 2023; 13:1241608.
Spottiswoode N, Hao S, Sanchez-Guerrero E, Detweiler AM, Mekonen H, Neff N, Macmillan H, Schwartz BS, Engel J, DeRisi JL, Miller SA, Langelier CR. PMID: 37712060; PMCID: PMC10499174.
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PubMed Mentions:
2 Fields:
Translation:
HumansCells
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Clinical and biological heterogeneity of multisystem inflammatory syndrome in adults following SARS-CoV-2 infection: a case series. Front Med (Lausanne). 2023; 10:1187420.
Barth KE, Spottiswoode N, Hurabielle C, Subbaraj L, COMET Consortium, Calfee CS, Matthay MA, French S, Connolly A, Hewitt SM, Vannella KM, Barnett C, Langelier CR, Patterson S. PMID: 37484839; PMCID: PMC10357379.
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Successful Treatment of Balamuthia mandrillaris Granulomatous Amebic Encephalitis with Nitroxoline. Emerg Infect Dis. 2023 01; 29(1):197-201.
Spottiswoode N, Pet D, Kim A, Gruenberg K, Shah M, Ramachandran A, Laurie MT, Zia M, Fouassier C, Boutros CL, Lu R, Zhang Y, Servellita V, Bollen A, Chiu CY, Wilson MR, Valdivia L, DeRisi JL. PMID: 36573629; PMCID: PMC9796214.
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PubMed Mentions:
11 Fields:
Translation:
HumansAnimals
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Maribavir for Cytomegalovirus Treatment in the Real World-Not a Silver Bullet. Open Forum Infect Dis. 2023 Jan; 10(1):ofac686.
Fung M, DeVoe C, Spottiswoode N, Doernberg SB. PMID: 36632422; PMCID: PMC9830537.
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PubMed Mentions:
5
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Prevalence of type-1 interferon autoantibodies in adults with non-COVID-19 acute respiratory failure. Respir Res. 2022 Dec 16; 23(1):354.
Ghale R, Spottiswoode N, Anderson MS, Mitchell A, Wang G, Calfee CS, DeRisi JL, Langelier CR. PMID: 36527083; PMCID: PMC9756918.
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PubMed Mentions:
4 Fields:
Translation:
Humans
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Upper airway gene expression shows a more robust adaptive immune response to SARS-CoV-2 in children. Nat Commun. 2022 07 08; 13(1):3937.
Mick E, Tsitsiklis A, Spottiswoode N, Caldera S, Serpa PH, Detweiler AM, Neff N, Pisco AO, Li LM, Retallack H, Ratnasiri K, Williamson KM, Soesanto V, Simões EAF, Smith C, Abuogi L, Kistler A, Wagner BD, DeRisi JL, Ambroggio L, Mourani PM, Langelier CR. PMID: 35803954; PMCID: PMC9263813.
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PubMed Mentions:
7 Fields:
Translation:
HumansCells
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Impact of e-cigarette aerosol on primary human alveolar epithelial type 2 cells. Am J Physiol Lung Cell Mol Physiol. 2022 08 01; 323(2):L152-L164.
Wick KD, Fang X, Maishan M, Matsumoto S, Spottiswoode N, Sarma A, Simoneau C, Khakoo M, Langelier C, Calfee CS, Gotts JE, Matthay MA. PMID: 35670478; PMCID: PMC9559034.
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PubMed Mentions:
2 Fields:
Translation:
HumansCells
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Pneumonia surveillance with culture-independent metatranscriptomics in HIV-positive adults in Uganda: a cross-sectional study. Lancet Microbe. 2022 05; 3(5):e357-e365.
Spottiswoode N, Bloomstein JD, Caldera S, Sessolo A, McCauley K, Byanyima P, Zawedde J, Kalantar K, Kaswabuli S, Rutishauser RL, Lieng MK, Davis JL, Moore J, Jan A, Iwai S, Shenoy M, Sanyu I, DeRisi JL, Lynch SV, Worodria W, Huang L, Langelier CR. PMID: 35544096.
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5 Fields:
Translation:
HumansCells
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Tracheal aspirate RNA sequencing identifies distinct immunological features of COVID-19 ARDS. Nat Commun. 2021 08 26; 12(1):5152.
Sarma A, Christenson SA, Byrne A, Mick E, Pisco AO, DeVoe C, Deiss T, Ghale R, Zha BS, Tsitsiklis A, Jauregui A, Moazed F, Detweiler AM, Spottiswoode N, Sinha P, Neff N, Tan M, Serpa PH, Willmore A, Ansel KM, Wilson JG, Leligdowicz A, Siegel ER, Sirota M, DeRisi JL, Matthay MA, COMET Consortium, Hendrickson CM, Kangelaris KN, Krummel MF, Woodruff PG, Erle DJ, Calfee CS, Langelier CR. PMID: 34446707; PMCID: PMC8390461.
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PubMed Mentions:
31 Fields:
Translation:
HumansCells
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Upper airway gene expression reveals a more robust innate and adaptive immune response to SARS-CoV-2 in children compared with older adults. Res Sq. 2021 Aug 26.
Mick E, Tsitsiklis A, Spottiswoode N, Caldera S, Serpa PH, Detweiler AM, Neff N, Pisco AO, Li LM, Retallack H, Ratnasiri K, Williamson KM, Soesanto V, Simões EAF, Kistler A, Wagner BD, DeRisi JL, Ambroggio L, Mourani PM, Langelier CR. PMID: 34462739; PMCID: PMC8404906.
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PubMed Mentions:
2
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COVID-19 ARDS is characterized by a dysregulated host response that differs from cytokine storm and is modified by dexamethasone. Res Sq. 2021 Jan 14.
Sarma A, Christenson SA, Mick E, DeVoe C, Deiss T, Pisco AO, Ghale R, Jauregui A, Byrne A, Moazed F, Spottiswoode N, Sinha P, Zha BS, Neff N, Tan M, Serpa PH, Ansel KM, Wilson JG, Leligdowicz A, Siegel ER, Sirota M, DeRisi JL, Matthay MA, COMET Consortium, Hendrickson CM, Kangelaris KN, Krummel MF, Woodruff PG, Erle DJ, Calfee CS, Langelier CR. PMID: 33469573; PMCID: PMC7814832.
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PubMed Mentions:
3
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Upper airway gene expression reveals suppressed immune responses to SARS-CoV-2 compared with other respiratory viruses. Nat Commun. 2020 11 17; 11(1):5854.
Mick E, Kamm J, Pisco AO, Ratnasiri K, Babik JM, Castañeda G, DeRisi JL, Detweiler AM, Hao SL, Kangelaris KN, Kumar GR, Li LM, Mann SA, Neff N, Prasad PA, Serpa PH, Shah SJ, Spottiswoode N, Tan M, Calfee CS, Christenson SA, Kistler A, Langelier C. PMID: 33203890; PMCID: PMC7673985.
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PubMed Mentions:
94 Fields:
Translation:
HumansCellsPHPublic Health
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Clinical features, diagnostics, and outcomes of patients presenting with acute respiratory illness: A retrospective cohort study of patients with and without COVID-19. EClinicalMedicine. 2020 Oct; 27:100518.
Shah SJ, Barish PN, Prasad PA, Kistler A, Neff N, Kamm J, Li LM, Chiu CY, Babik JM, Fang MC, Abe-Jones Y, Alipanah N, Alvarez FN, Botvinnik OB, Castaneda G, CZB CLIAhub Consortium, Dadasovich RM, Davis J, Deng X, DeRisi JL, Detweiler AM, Federman S, Haliburton J, Hao S, Kerkhoff AD, Kumar GR, Malcolm KB, Mann SA, Martinez S, Mary RK, Mick E, Mwakibete L, Najafi N, Peluso MJ, Phelps M, Pisco AO, Ratnasiri K, Rubio LA, Sellas A, Sherwood KD, Sheu J, Spottiswoode N, Tan M, Yu G, Kangelaris KN, Langelier C. PMID: 32864588; PMCID: PMC7447618.
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46
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Upper airway gene expression differentiates COVID-19 from other acute respiratory illnesses and reveals suppression of innate immune responses by SARS-CoV-2. medRxiv. 2020 May 19.
Mick E, Kamm J, Pisco AO, Ratnasiri K, Babik JM, Calfee CS, Castañeda G, DeRisi JL, Detweiler AM, Hao S, Kangelaris KN, Kumar GR, Li LM, Mann SA, Neff N, Prasad PA, Serpa PH, Shah SJ, Spottiswoode N, Tan M, Christenson SA, Kistler A, Langelier C. PMID: 32511476; PMCID: PMC7273244.
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PubMed Mentions:
1
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Clinical features, diagnostics, and outcomes of patients presenting with acute respiratory illness: a comparison of patients with and without COVID-19. medRxiv. 2020 May 06.
Shah SJ, Barish PN, Prasad PA, Kistler AL, Neff N, Kamm J, Li LM, Chiu CY, Babick JM, Fang MC, Abe-Jones Y, Alipanah N, Alvarez FN, Botvinnik OB, Davis JM, Castenada GD, Consortium C, Dadasovich RM, Deng X, DeRisi JL, Detweiler AM, Federman S, Haliburton JR, Hao SL, Kerkhoff AD, Kumar R, Malcolm K, Mann SA, Martinez SP, Marya R, Mick E, Mwakibete LL, Najafi N, Peluso MJ, Phelps MS, Pisco AO, Ratnasiri K, Rubio LA, Sellas AB, Sherwood KD, Sheu J, Spottiswoode N, Tan M, Yu G, Kangelaris KN, Langelier C. PMID: 32511488; PMCID: PMC7273256.
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2
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Inhibition of Resistance-Refractory P. falciparum Kinase PKG Delivers Prophylactic, Blood Stage, and Transmission-Blocking Antiplasmodial Activity. Cell Chem Biol. 2020 07 16; 27(7):806-816.e8.
Vanaerschot M, Murithi JM, Pasaje CFA, Ghidelli-Disse S, Dwomoh L, Bird M, Spottiswoode N, Mittal N, Arendse LB, Owen ES, Wicht KJ, Siciliano G, Bösche M, Yeo T, Kumar TRS, Mok S, Carpenter EF, Giddins MJ, Sanz O, Ottilie S, Alano P, Chibale K, Llinás M, Uhlemann AC, Delves M, Tobin AB, Doerig C, Winzeler EA, Lee MCS, Niles JC, Fidock DA. PMID: 32359426; PMCID: PMC7369637.
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PubMed Mentions:
40 Fields:
Translation:
HumansAnimalsCells
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ANALYSIS OF PLASMODIUM LINEAGES IDENTIFIED IN CAPTIVE PENGUINS (SPHENISCIFORMES SPP.), EIDERS (SOMATERIA SPP.), AND INCA TERNS (LAROSTERNA INCA) IN A NORTH AMERICAN ZOOLOGICAL COLLECTION. J Zoo Wildl Med. 2020 Mar 17; 51(1):140-149.
Spottiswoode N, Bartlett SL, Conley KJ, Seimon TA, Griffin DO, Sykes JM. PMID: 32212557.
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PubMed Mentions:
9 Fields:
Translation:
Animals
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Nontyphoidal Salmonella as a Cause of Mediastinal Abscess after Aortic Valve Replacement: A Case Report and Review of Postoperative Salmonella Infections. Case Rep Infect Dis. 2018; 2018:6758672.
Spottiswoode N, Peluso MJ, Deuse T, Babik JM. PMID: 30598848; PMCID: PMC6287146.
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PubMed Mentions:
2
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Role of Activins in Hepcidin Regulation during Malaria. Infect Immun. 2017 12; 85(12).
Spottiswoode N, Armitage AE, Williams AR, Fyfe AJ, Biswas S, Hodgson SH, Llewellyn D, Choudhary P, Draper SJ, Duffy PE, Drakesmith H. PMID: 28893916; PMCID: PMC5695100.
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PubMed Mentions:
12 Fields:
Translation:
HumansAnimals
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Cord Blood Hepcidin: Cross-Sectional Correlates and Associations with Anemia, Malaria, and Mortality in a Tanzanian Birth Cohort Study. Am J Trop Med Hyg. 2016 10 05; 95(4):817-826.
Brickley EB, Spottiswoode N, Kabyemela E, Morrison R, Kurtis JD, Wood AM, Drakesmith H, Fried M, Duffy PE. PMID: 27352871; PMCID: PMC5062780.
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PubMed Mentions:
7 Fields:
Translation:
Humans
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Profiling the Essential Nature of Lipid Metabolism in Asexual Blood and Gametocyte Stages of Plasmodium falciparum. Cell Host Microbe. 2015 Sep 09; 18(3):371-81.
Gulati S, Ekland EH, Ruggles KV, Chan RB, Jayabalasingham B, Zhou B, Mantel PY, Lee MC, Spottiswoode N, Coburn-Flynn O, Hjelmqvist D, Worgall TS, Marti M, Di Paolo G, Fidock DA. PMID: 26355219; PMCID: PMC4567697.
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PubMed Mentions:
91 Fields:
Translation:
Animals
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Genome sequencing of chimpanzee malaria parasites reveals possible pathways of adaptation to human hosts. Nat Commun. 2014 Sep 09; 5:4754.
Otto TD, Rayner JC, Böhme U, Pain A, Spottiswoode N, Sanders M, Quail M, Ollomo B, Renaud F, Thomas AW, Prugnolle F, Conway DJ, Newbold C, Berriman M. PMID: 25203297; PMCID: PMC4166903.
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PubMed Mentions:
87 Fields:
Translation:
HumansAnimalsCells
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Iron, anemia and hepcidin in malaria. Front Pharmacol. 2014; 5:125.
Spottiswoode N, Duffy PE, Drakesmith H. PMID: 24910614; PMCID: PMC4039013.
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PubMed Mentions:
65
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Implications of malaria on iron deficiency control strategies. Adv Nutr. 2012 Jul 01; 3(4):570-8.
Spottiswoode N, Fried M, Drakesmith H, Duffy PE. PMID: 22797994; PMCID: PMC3649728.
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PubMed Mentions:
20 Fields:
Translation:
Humans
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Hepcidin regulation by innate immune and infectious stimuli. Blood. 2011 Oct 13; 118(15):4129-39.
Armitage AE, Eddowes LA, Gileadi U, Cole S, Spottiswoode N, Selvakumar TA, Ho LP, Townsend AR, Drakesmith H. PMID: 21873546.
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PubMed Mentions:
141 Fields:
Translation:
HumansAnimalsCells
This graph shows the total number of publications by year. To see the data as text,
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This graph shows the total number of publications by year. To return to the graph,
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Year | Publications |
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2011 | 1 |
2012 | 1 |
2014 | 2 |
2015 | 1 |
2016 | 1 |
2017 | 1 |
2018 | 1 |
2020 | 6 |
2021 | 3 |
2022 | 5 |
2023 | 3 |
2024 | 5 |
This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text,
click here.
This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text,
click here.
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