Natasha Spottiswoode, MD, PhD

Title(s)Assistant Professor, Medicine
SchoolSchool of Medicine
Address513 Parnassus Avenue, HSE, #380
San Francisco CA 94143
Phone415-353-7900
PronounsShe/Her/Hers
ORCID ORCID Icon0000-0001-6157-3716 Additional info
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    Collapse Biography 
    Collapse Education and Training
    California State University Los Angeles , Los Angeles, CABS06/2018Biology
    University of Oxford, UKBSc09/2010Integrative Bioscience
    University of Oxford/National Institutes of Health, UK/MarylandDPhil06/2014Biomedical Sciences
    Columbia University Vagelos College of Physicians and Surgeons, New YorkMD05/2018Medicine
    University of California San Francisco Medical Center, San Francisco06/2021Medicine Residency
    University of California San Francisco, San FranciscoInfectious Disease Fellowship
    Collapse Awards and Honors
    Center for Pandemic Preparedness Response2023  - 2024CPPR Investigator Seed Award
    NIPLH2022  - 2023Nina Ireland Award
    Centers for Disease Control and Prevention2020David J Sencer Scholarship
    Department of Medicine, UCSF2020Poetry Award
    Infectious Disease Week2022Travel Bursary

    Collapse Overview 
    Collapse Overview
    Infectious disease physician-scientist with a focused on unbiased diagnostics and developing treatments for uncommon infections.

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Rewriting the Script. Clin Infect Dis. 2024 Nov 27. Spottiswoode N, Minter DJ, Friedman-Moraco R. PMID: 39600205.
      View in: PubMed   Mentions:    Fields:    
    2. Microbial dynamics and pulmonary immune responses in COVID-19 secondary bacterial pneumonia. Nat Commun. 2024 Oct 29; 15(1):9339. Spottiswoode N, Tsitsiklis A, Chu VT, Phan HV, DeVoe C, Love C, Ghale R, Bloomstein J, Zha BS, Maguire CP, Glascock A, Sarma A, Mourani PM, Kalantar KL, Detweiler A, Neff N, Haller SC, COMET Consortium, DeRisi JL, Erle DJ, Hendrickson CM, Kangelaris KN, Krummel MF, Matthay MA, Woodruff PG, Calfee CS, Langelier CR. PMID: 39472555; PMCID: PMC11522429.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    3. Pulmonary FABP4 Is an Inverse Biomarker of Pneumonia in Critically Ill Children and Adults. Am J Respir Crit Care Med. 2024 Sep 23. Lydon EC, Phan HV, Mick E, Spottiswoode N, Calfee CS, Mourani PM, Langelier CR. PMID: 39312201.
      View in: PubMed   Mentions:    Fields:    
    4. Advancing Sepsis Endotyping Globally: Lessons From a Prospective Study in Uganda. Crit Care Med. 2024 03 01; 52(3):515-517. Neyton L, Spottiswoode N. PMID: 38381016; PMCID: PMC10883597.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. Challenges and advances in the medical treatment of granulomatous amebic encephalitis. Ther Adv Infect Dis. 2024 Jan-Dec; 11:20499361241228340. Spottiswoode N, Haston JC, Hanners NW, Gruenberg K, Kim A, DeRisi JL, Wilson MR. PMID: 38312848; PMCID: PMC10838035.
      View in: PubMed   Mentions: 1  
    6. In host evolution of beta lactam resistance during active treatment for Pseudomonas aeruginosa bacteremia. Front Cell Infect Microbiol. 2023; 13:1241608. Spottiswoode N, Hao S, Sanchez-Guerrero E, Detweiler AM, Mekonen H, Neff N, Macmillan H, Schwartz BS, Engel J, DeRisi JL, Miller SA, Langelier CR. PMID: 37712060; PMCID: PMC10499174.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    7. Clinical and biological heterogeneity of multisystem inflammatory syndrome in adults following SARS-CoV-2 infection: a case series. Front Med (Lausanne). 2023; 10:1187420. Barth KE, Spottiswoode N, Hurabielle C, Subbaraj L, COMET Consortium, Calfee CS, Matthay MA, French S, Connolly A, Hewitt SM, Vannella KM, Barnett C, Langelier CR, Patterson S. PMID: 37484839; PMCID: PMC10357379.
      View in: PubMed   Mentions:
    8. Successful Treatment of Balamuthia mandrillaris Granulomatous Amebic Encephalitis with Nitroxoline. Emerg Infect Dis. 2023 01; 29(1):197-201. Spottiswoode N, Pet D, Kim A, Gruenberg K, Shah M, Ramachandran A, Laurie MT, Zia M, Fouassier C, Boutros CL, Lu R, Zhang Y, Servellita V, Bollen A, Chiu CY, Wilson MR, Valdivia L, DeRisi JL. PMID: 36573629; PMCID: PMC9796214.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    9. Maribavir for Cytomegalovirus Treatment in the Real World-Not a Silver Bullet. Open Forum Infect Dis. 2023 Jan; 10(1):ofac686. Fung M, DeVoe C, Spottiswoode N, Doernberg SB. PMID: 36632422; PMCID: PMC9830537.
      View in: PubMed   Mentions: 5  
    10. Prevalence of type-1 interferon autoantibodies in adults with non-COVID-19 acute respiratory failure. Respir Res. 2022 Dec 16; 23(1):354. Ghale R, Spottiswoode N, Anderson MS, Mitchell A, Wang G, Calfee CS, DeRisi JL, Langelier CR. PMID: 36527083; PMCID: PMC9756918.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    11. Upper airway gene expression shows a more robust adaptive immune response to SARS-CoV-2 in children. Nat Commun. 2022 07 08; 13(1):3937. Mick E, Tsitsiklis A, Spottiswoode N, Caldera S, Serpa PH, Detweiler AM, Neff N, Pisco AO, Li LM, Retallack H, Ratnasiri K, Williamson KM, Soesanto V, Simões EAF, Smith C, Abuogi L, Kistler A, Wagner BD, DeRisi JL, Ambroggio L, Mourani PM, Langelier CR. PMID: 35803954; PMCID: PMC9263813.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    12. Impact of e-cigarette aerosol on primary human alveolar epithelial type 2 cells. Am J Physiol Lung Cell Mol Physiol. 2022 08 01; 323(2):L152-L164. Wick KD, Fang X, Maishan M, Matsumoto S, Spottiswoode N, Sarma A, Simoneau C, Khakoo M, Langelier C, Calfee CS, Gotts JE, Matthay MA. PMID: 35670478; PMCID: PMC9559034.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    13. Pneumonia surveillance with culture-independent metatranscriptomics in HIV-positive adults in Uganda: a cross-sectional study. Lancet Microbe. 2022 05; 3(5):e357-e365. Spottiswoode N, Bloomstein JD, Caldera S, Sessolo A, McCauley K, Byanyima P, Zawedde J, Kalantar K, Kaswabuli S, Rutishauser RL, Lieng MK, Davis JL, Moore J, Jan A, Iwai S, Shenoy M, Sanyu I, DeRisi JL, Lynch SV, Worodria W, Huang L, Langelier CR. PMID: 35544096.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    14. Tracheal aspirate RNA sequencing identifies distinct immunological features of COVID-19 ARDS. Nat Commun. 2021 08 26; 12(1):5152. Sarma A, Christenson SA, Byrne A, Mick E, Pisco AO, DeVoe C, Deiss T, Ghale R, Zha BS, Tsitsiklis A, Jauregui A, Moazed F, Detweiler AM, Spottiswoode N, Sinha P, Neff N, Tan M, Serpa PH, Willmore A, Ansel KM, Wilson JG, Leligdowicz A, Siegel ER, Sirota M, DeRisi JL, Matthay MA, COMET Consortium, Hendrickson CM, Kangelaris KN, Krummel MF, Woodruff PG, Erle DJ, Calfee CS, Langelier CR. PMID: 34446707; PMCID: PMC8390461.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    15. Upper airway gene expression reveals a more robust innate and adaptive immune response to SARS-CoV-2 in children compared with older adults. Res Sq. 2021 Aug 26. Mick E, Tsitsiklis A, Spottiswoode N, Caldera S, Serpa PH, Detweiler AM, Neff N, Pisco AO, Li LM, Retallack H, Ratnasiri K, Williamson KM, Soesanto V, Simões EAF, Kistler A, Wagner BD, DeRisi JL, Ambroggio L, Mourani PM, Langelier CR. PMID: 34462739; PMCID: PMC8404906.
      View in: PubMed   Mentions: 2  
    16. COVID-19 ARDS is characterized by a dysregulated host response that differs from cytokine storm and is modified by dexamethasone. Res Sq. 2021 Jan 14. Sarma A, Christenson SA, Mick E, DeVoe C, Deiss T, Pisco AO, Ghale R, Jauregui A, Byrne A, Moazed F, Spottiswoode N, Sinha P, Zha BS, Neff N, Tan M, Serpa PH, Ansel KM, Wilson JG, Leligdowicz A, Siegel ER, Sirota M, DeRisi JL, Matthay MA, COMET Consortium, Hendrickson CM, Kangelaris KN, Krummel MF, Woodruff PG, Erle DJ, Calfee CS, Langelier CR. PMID: 33469573; PMCID: PMC7814832.
      View in: PubMed   Mentions: 3  
    17. Upper airway gene expression reveals suppressed immune responses to SARS-CoV-2 compared with other respiratory viruses. Nat Commun. 2020 11 17; 11(1):5854. Mick E, Kamm J, Pisco AO, Ratnasiri K, Babik JM, Castañeda G, DeRisi JL, Detweiler AM, Hao SL, Kangelaris KN, Kumar GR, Li LM, Mann SA, Neff N, Prasad PA, Serpa PH, Shah SJ, Spottiswoode N, Tan M, Calfee CS, Christenson SA, Kistler A, Langelier C. PMID: 33203890; PMCID: PMC7673985.
      View in: PubMed   Mentions: 95     Fields:    Translation:HumansCellsPHPublic Health
    18. Clinical features, diagnostics, and outcomes of patients presenting with acute respiratory illness: A retrospective cohort study of patients with and without COVID-19. EClinicalMedicine. 2020 Oct; 27:100518. Shah SJ, Barish PN, Prasad PA, Kistler A, Neff N, Kamm J, Li LM, Chiu CY, Babik JM, Fang MC, Abe-Jones Y, Alipanah N, Alvarez FN, Botvinnik OB, Castaneda G, CZB CLIAhub Consortium, Dadasovich RM, Davis J, Deng X, DeRisi JL, Detweiler AM, Federman S, Haliburton J, Hao S, Kerkhoff AD, Kumar GR, Malcolm KB, Mann SA, Martinez S, Mary RK, Mick E, Mwakibete L, Najafi N, Peluso MJ, Phelps M, Pisco AO, Ratnasiri K, Rubio LA, Sellas A, Sherwood KD, Sheu J, Spottiswoode N, Tan M, Yu G, Kangelaris KN, Langelier C. PMID: 32864588; PMCID: PMC7447618.
      View in: PubMed   Mentions: 46  
    19. Upper airway gene expression differentiates COVID-19 from other acute respiratory illnesses and reveals suppression of innate immune responses by SARS-CoV-2. medRxiv. 2020 May 19. Mick E, Kamm J, Pisco AO, Ratnasiri K, Babik JM, Calfee CS, Castañeda G, DeRisi JL, Detweiler AM, Hao S, Kangelaris KN, Kumar GR, Li LM, Mann SA, Neff N, Prasad PA, Serpa PH, Shah SJ, Spottiswoode N, Tan M, Christenson SA, Kistler A, Langelier C. PMID: 32511476; PMCID: PMC7273244.
      View in: PubMed   Mentions: 1  
    20. Clinical features, diagnostics, and outcomes of patients presenting with acute respiratory illness: a comparison of patients with and without COVID-19. medRxiv. 2020 May 06. Shah SJ, Barish PN, Prasad PA, Kistler AL, Neff N, Kamm J, Li LM, Chiu CY, Babick JM, Fang MC, Abe-Jones Y, Alipanah N, Alvarez FN, Botvinnik OB, Davis JM, Castenada GD, Consortium C, Dadasovich RM, Deng X, DeRisi JL, Detweiler AM, Federman S, Haliburton JR, Hao SL, Kerkhoff AD, Kumar R, Malcolm K, Mann SA, Martinez SP, Marya R, Mick E, Mwakibete LL, Najafi N, Peluso MJ, Phelps MS, Pisco AO, Ratnasiri K, Rubio LA, Sellas AB, Sherwood KD, Sheu J, Spottiswoode N, Tan M, Yu G, Kangelaris KN, Langelier C. PMID: 32511488; PMCID: PMC7273256.
      View in: PubMed   Mentions: 2  
    21. Inhibition of Resistance-Refractory P. falciparum Kinase PKG Delivers Prophylactic, Blood Stage, and Transmission-Blocking Antiplasmodial Activity. Cell Chem Biol. 2020 07 16; 27(7):806-816.e8. Vanaerschot M, Murithi JM, Pasaje CFA, Ghidelli-Disse S, Dwomoh L, Bird M, Spottiswoode N, Mittal N, Arendse LB, Owen ES, Wicht KJ, Siciliano G, Bösche M, Yeo T, Kumar TRS, Mok S, Carpenter EF, Giddins MJ, Sanz O, Ottilie S, Alano P, Chibale K, Llinás M, Uhlemann AC, Delves M, Tobin AB, Doerig C, Winzeler EA, Lee MCS, Niles JC, Fidock DA. PMID: 32359426; PMCID: PMC7369637.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    22. ANALYSIS OF PLASMODIUM LINEAGES IDENTIFIED IN CAPTIVE PENGUINS (SPHENISCIFORMES SPP.), EIDERS (SOMATERIA SPP.), AND INCA TERNS (LAROSTERNA INCA) IN A NORTH AMERICAN ZOOLOGICAL COLLECTION. J Zoo Wildl Med. 2020 Mar 17; 51(1):140-149. Spottiswoode N, Bartlett SL, Conley KJ, Seimon TA, Griffin DO, Sykes JM. PMID: 32212557.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    23. Nontyphoidal Salmonella as a Cause of Mediastinal Abscess after Aortic Valve Replacement: A Case Report and Review of Postoperative Salmonella Infections. Case Rep Infect Dis. 2018; 2018:6758672. Spottiswoode N, Peluso MJ, Deuse T, Babik JM. PMID: 30598848; PMCID: PMC6287146.
      View in: PubMed   Mentions: 2  
    24. Role of Activins in Hepcidin Regulation during Malaria. Infect Immun. 2017 12; 85(12). Spottiswoode N, Armitage AE, Williams AR, Fyfe AJ, Biswas S, Hodgson SH, Llewellyn D, Choudhary P, Draper SJ, Duffy PE, Drakesmith H. PMID: 28893916; PMCID: PMC5695100.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    25. Cord Blood Hepcidin: Cross-Sectional Correlates and Associations with Anemia, Malaria, and Mortality in a Tanzanian Birth Cohort Study. Am J Trop Med Hyg. 2016 10 05; 95(4):817-826. Brickley EB, Spottiswoode N, Kabyemela E, Morrison R, Kurtis JD, Wood AM, Drakesmith H, Fried M, Duffy PE. PMID: 27352871; PMCID: PMC5062780.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    26. Profiling the Essential Nature of Lipid Metabolism in Asexual Blood and Gametocyte Stages of Plasmodium falciparum. Cell Host Microbe. 2015 Sep 09; 18(3):371-81. Gulati S, Ekland EH, Ruggles KV, Chan RB, Jayabalasingham B, Zhou B, Mantel PY, Lee MC, Spottiswoode N, Coburn-Flynn O, Hjelmqvist D, Worgall TS, Marti M, Di Paolo G, Fidock DA. PMID: 26355219; PMCID: PMC4567697.
      View in: PubMed   Mentions: 91     Fields:    Translation:Animals
    27. Genome sequencing of chimpanzee malaria parasites reveals possible pathways of adaptation to human hosts. Nat Commun. 2014 Sep 09; 5:4754. Otto TD, Rayner JC, Böhme U, Pain A, Spottiswoode N, Sanders M, Quail M, Ollomo B, Renaud F, Thomas AW, Prugnolle F, Conway DJ, Newbold C, Berriman M. PMID: 25203297; PMCID: PMC4166903.
      View in: PubMed   Mentions: 87     Fields:    Translation:HumansAnimalsCells
    28. Iron, anemia and hepcidin in malaria. Front Pharmacol. 2014; 5:125. Spottiswoode N, Duffy PE, Drakesmith H. PMID: 24910614; PMCID: PMC4039013.
      View in: PubMed   Mentions: 65  
    29. Implications of malaria on iron deficiency control strategies. Adv Nutr. 2012 Jul 01; 3(4):570-8. Spottiswoode N, Fried M, Drakesmith H, Duffy PE. PMID: 22797994; PMCID: PMC3649728.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    30. Hepcidin regulation by innate immune and infectious stimuli. Blood. 2011 Oct 13; 118(15):4129-39. Armitage AE, Eddowes LA, Gileadi U, Cole S, Spottiswoode N, Selvakumar TA, Ho LP, Townsend AR, Drakesmith H. PMID: 21873546.
      View in: PubMed   Mentions: 141     Fields:    Translation:HumansAnimalsCells
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