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    Andrew Krystal, MD

    TitleProfessor
    SchoolUCSF School of Medicine
    DepartmentPsychiatry
    Address401 Parnassus Ave.
    San Francisco CA 94143
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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Nunn CL, Samson DR, Krystal AD. Shining evolutionary light on human sleep and sleep disorders. Evol Med Public Health. 2016; 2016(1):227-43. PMID: 27470330.
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      2. Krystal JH, Abi-Dargham A, Akbarian S, Arnsten AF, Barch DM, Bearden CE, Braff DL, Brown ES, Bullmore ET, Carlezon WA, Carter CS, Cook EH, Daskalakis ZJ, DiLeone RJ, Duman RS, Grace AA, Hariri AR, Harrison PJ, Hiroi N, Kenny PJ, Kleinman JE, Krystal AD, Lewis DA, Lipska BK, Marder SR, Mason GF, Mathalon DH, McClung CA, McDougle CJ, McIntosh AM, McMahon FJ, Mirnics K, Monteggia LM, Narendran R, Nestler EJ, Neumeister A, O'Donovan MC, Öngür D, Pariante CM, Paulus MP, Pearlson G, Phillips ML, Pine DS, Pizzagalli DA, Pletnikov MV, Ragland JD, Rapoport JL, Ressler KJ, Russo SJ, Sanacora G, Sawa A, Schatzberg AF, Shaham Y, Shamay-Tsoory SG, Sklar P, State MW, Stein MB, Strakowski SM, Taylor SF, Turecki G, Turetsky BI, Weissman MM, Zachariou V, Zarate CA, Zubieta JK. Constance E. Lieber, Theodore R. Stanley, and the Enduring Impact of Philanthropy on Psychiatry Research. Biol Psychiatry. 2016 Jul 15; 80(2):84-6. PMID: 27346079.
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      3. Bathgate CJ, Edinger JD, Wyatt JK, Krystal AD. Objective but Not Subjective Short Sleep Duration Associated with Increased Risk for Hypertension in Individuals with Insomnia. Sleep. 2016; 39(5):1037-45. PMID: 26951399.
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      4. Krystal AD, Zammit G. The sleep effects of lurasidone: a placebo-controlled cross-over study using a 4-h phase-advance model of transient insomnia. Hum Psychopharmacol. 2016 May; 31(3):206-16. PMID: 27108672.
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      5. Krystal JH, Pietrzak RH, Rosenheck RA, Cramer JA, Vessicchio J, Jones KM, Huang GD, Vertrees JE, Collins J, Krystal AD. Sleep disturbance in chronic military-related PTSD: clinical impact and response to adjunctive risperidone in the Veterans Affairs cooperative study #504. J Clin Psychiatry. 2016 Apr; 77(4):483-91. PMID: 26890894.
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      6. Krystal AD, Sorscher AJ. Recognizing and managing insomnia in primary care and specialty settings. J Clin Psychiatry. 2016 Apr; 77(4):e471. PMID: 27137433.
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      7. Morin CM, Edinger JD, Krystal AD, Buysse DJ, Beaulieu-Bonneau S, Ivers H. Sequential psychological and pharmacological therapies for comorbid and primary insomnia: study protocol for a randomized controlled trial. Trials. 2016; 17(1):118. PMID: 26940892.
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      8. Krystal AD. New Developments in Insomnia Medications of Relevance to Mental Health Disorders. Psychiatr Clin North Am. 2015 Dec; 38(4):843-60. PMID: 26600112.
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      9. Morin CM, Drake CL, Harvey AG, Krystal AD, Manber R, Riemann D, Spiegelhalder K. Insomnia disorder. Nat Rev Dis Primers. 2015; 1:15026. PMID: 27189779.
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      10. Krystal AD. Current, emerging, and newly available insomnia medications. J Clin Psychiatry. 2015 Aug; 76(8):e1045. PMID: 26335094.
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      11. Krystal JH, Stossel S, Krystal AD. Restricting Benzodiazepines to Short-Term Prescription. JAMA Psychiatry. 2015 Jul; 72(7):734-5. PMID: 25923129.
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      12. Leuchter AF, Cook IA, Feifel D, Goethe JW, Husain M, Carpenter LL, Thase ME, Krystal AD, Philip NS, Bhati MT, Burke WJ, Howland RH, Sheline YI, Aaronson ST, Iosifescu DV, O'Reardon JP, Gilmer WS, Jain R, Burgoyne KS, Phillips B, Manberg PJ, Massaro J, Hunter AM, Lisanby SH, George MS. Efficacy and Safety of Low-field Synchronized Transcranial Magnetic Stimulation (sTMS) for Treatment of Major Depression. Brain Stimul. 2015 Jul-Aug; 8(4):787-94. PMID: 26143022.
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      13. Peterchev AV, Krystal AD, Rosa MA, Lisanby SH. Individualized Low-Amplitude Seizure Therapy: Minimizing Current for Electroconvulsive Therapy and Magnetic Seizure Therapy. Neuropsychopharmacology. 2015 Aug; 40(9):2076-84. PMID: 25920013; PMCID: PMC4613599 [Available on 08/01/16].
      14. Ivgy-May N, Ruwe F, Krystal A, Roth T. Esmirtazapine in non-elderly adult patients with primary insomnia: efficacy and safety from a randomized, 6-week sleep laboratory trial. Sleep Med. 2015 Jul; 16(7):838-44. PMID: 26047892.
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      15. McCall WV, Benca RM, Rosenquist PB, Riley MA, Hodges C, Gubosh B, McCloud L, Newman JC, Case D, Rumble M, Mayo M, White KH, Phillips M, Krystal AD. A multi-site randomized clinical trial to reduce suicidal ideation in suicidal adult outpatients with Major Depressive Disorder: Development of a methodology to enhance safety. Clin Trials. 2015 Jun; 12(3):189-98. PMID: 25733676; PMCID: PMC4424155 [Available on 06/01/16].
      16. Rapp PE, Keyser DO, Albano A, Hernandez R, Gibson DB, Zambon RA, Hairston WD, Hughes JD, Krystal A, Nichols AS. Traumatic brain injury detection using electrophysiological methods. Front Hum Neurosci. 2015; 9:11. PMID: 25698950; PMCID: PMC4316720.
      17. Tek C, Palmese LB, Krystal AD, Srihari VH, DeGeorge PC, Reutenauer EL, Guloksuz S. The impact of eszopiclone on sleep and cognition in patients with schizophrenia and insomnia: a double-blind, randomized, placebo-controlled trial. Schizophr Res. 2014 Dec; 160(1-3):180-5. PMID: 25454802.
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      18. Herring WJ, Connor KM, Ivgy-May N, Snyder E, Liu K, Snavely DB, Krystal AD, Walsh JK, Benca RM, Rosenberg R, Sangal RB, Budd K, Hutzelmann J, Leibensperger H, Froman S, Lines C, Roth T, Michelson D. Suvorexant in Patients With Insomnia: Results From Two 3-Month Randomized Controlled Clinical Trials. Biol Psychiatry. 2016 Jan 15; 79(2):136-48. PMID: 25526970.
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      19. Calabrese JR, Fava M, Garibaldi G, Grunze H, Krystal AD, Laughren T, Macfadden W, Marin R, Nierenberg AA, Tohen M. Methodological approaches and magnitude of the clinical unmet need associated with amotivation in mood disorders. J Affect Disord. 2014 Oct; 168:439-51. PMID: 25113957.
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      20. Goforth HW, Preud'homme XA, Krystal AD. A randomized, double-blind, placebo-controlled trial of eszopiclone for the treatment of insomnia in patients with chronic low back pain. Sleep. 2014 Jun; 37(6):1053-60. PMID: 24882900; PMCID: PMC4015379.
      21. McClintock SM, Choi J, Deng ZD, Appelbaum LG, Krystal AD, Lisanby SH. Multifactorial determinants of the neurocognitive effects of electroconvulsive therapy. J ECT. 2014 Jun; 30(2):165-76. PMID: 24820942; PMCID: PMC4143898.
      22. Michelson D, Snyder E, Paradis E, Chengan-Liu M, Snavely DB, Hutzelmann J, Walsh JK, Krystal AD, Benca RM, Cohn M, Lines C, Roth T, Herring WJ. Safety and efficacy of suvorexant during 1-year treatment of insomnia with subsequent abrupt treatment discontinuation: a phase 3 randomised, double-blind, placebo-controlled trial. Lancet Neurol. 2014 May; 13(5):461-71. PMID: 24680372.
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      23. Greve DN, Duntley SP, Larson-Prior L, Krystal AD, Diaz MT, Drummond SP, Thein SG, Kushida CA, Yang R, Thomas RJ. Effect of armodafinil on cortical activity and working memory in patients with residual excessive sleepiness associated with CPAP-Treated OSA: a multicenter fMRI study. J Clin Sleep Med. 2014 Feb 15; 10(2):143-53. PMID: 24532997; PMCID: PMC3899316.
      24. Low Y, Goforth H, Preud'homme X, Edinger J, Krystal A. Insomnia in HIV-infected patients: pathophysiologic implications. AIDS Rev. 2014 Jan-Mar; 16(1):3-13. PMID: 24522778.
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      25. Krystal AD, Zhang W, Davidson JR, Connor KM. The sleep effects of tiagabine on the first night of treatment predict post-traumatic stress disorder response at three weeks. J Psychopharmacol. 2014 May; 28(5):457-65. PMID: 24288237.
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      26. Wang X, Bey AL, Chung L, Krystal AD, Jiang YH. Therapeutic approaches for shankopathies. Dev Neurobiol. 2014 Feb; 74(2):123-35. PMID: 23536326; PMCID: PMC3883807.
      27. Krystal AD, Schopler B, Kobbe S, Williams C, Rakatondrainibe H, Yoder AD, Klopfer P. The relationship of sleep with temperature and metabolic rate in a hibernating primate. PLoS One. 2013; 8(9):e69914. PMID: 24023713; PMCID: PMC3762832.
      28. Edinger JD, Means MK, Krystal AD. Does physiological hyperarousal enhance error rates among insomnia sufferers? Sleep. 2013 Aug; 36(8):1179-86. PMID: 23904678; PMCID: PMC3700715.
      29. Mirrakhimov AE, Brewbaker CL, Krystal AD, Kwatra MM. Obstructive sleep apnea and delirium: exploring possible mechanisms. Sleep Breath. 2014 Mar; 18(1):19-29. PMID: 23584846.
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      30. Roth T, Krystal A, Steinberg FJ, Singh NN, Moline M. Novel sublingual low-dose zolpidem tablet reduces latency to sleep onset following spontaneous middle-of-the-night awakening in insomnia in a randomized, double-blind, placebo-controlled, outpatient study. Sleep. 2013 Feb; 36(2):189-96. PMID: 23372266; PMCID: PMC3543068.
      31. Krystal AD, Richelson E, Roth T. Review of the histamine system and the clinical effects of H1 antagonists: basis for a new model for understanding the effects of insomnia medications. Sleep Med Rev. 2013 Aug; 17(4):263-72. PMID: 23357028.
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      32. Krystal AD, Benca RM, Kilduff TS. Understanding the sleep-wake cycle: sleep, insomnia, and the orexin system. J Clin Psychiatry. 2013; 74 Suppl 1:3-20. PMID: 24107804.
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      33. Krystal AD. Psychiatric disorders and sleep. Neurol Clin. 2012 Nov; 30(4):1389-413. PMID: 23099143; PMCID: PMC3493205.
      34. Rosenquist PB, Krystal A, Heart KL, Demitrack MA, McCall WV. Left dorsolateral prefrontal transcranial magnetic stimulation (TMS): sleep factor changes during treatment in patients with pharmacoresistant major depressive disorder. Psychiatry Res. 2013 Jan 30; 205(1-2):67-73. PMID: 23021320.
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      35. Preud'homme XA, Amundsen CL, Webster GD, Krystal AD. Comparison of diary-derived bladder and sleep measurements across OAB individuals, primary insomniacs, and healthy controls. Int Urogynecol J. 2013 Mar; 24(3):501-8. PMID: 22855113.
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      36. Krystal AD, Roth T, Simon RD. Shift work disorder case studies: applying management principles in clinical practice. J Clin Psychiatry. 2012 Aug; 73(8):e25. PMID: 22967784.
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      37. Krystal AD, McCall WV, Fava M, Joffe H, Soares CN, Huang H, Grinell T, Zummo J, Spalding W, Marshall R. Eszopiclone treatment for insomnia: effect size comparisons in patients with primary insomnia and insomnia with medical and psychiatric comorbidity. Prim Care Companion CNS Disord. 2012; 14(4). PMID: 23251857; PMCID: PMC3505126.
      38. Low Y, Goforth HW, Omonuwa T, Preud'homme X, Edinger J, Krystal A. Comparison of polysomnographic data in age-, sex- and Axis I psychiatric diagnosis matched HIV-seropositive and HIV-seronegative insomnia patients. Clin Neurophysiol. 2012 Dec; 123(12):2402-5. PMID: 22727712.
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      39. Ohayon MM, Mahowald MW, Dauvilliers Y, Krystal AD, Léger D. Prevalence and comorbidity of nocturnal wandering in the U.S. adult general population. Neurology. 2012 May 15; 78(20):1583-9. PMID: 22585435; PMCID: PMC3467644.
      40. Krystal AD, Sutherland J, Hochman DW. Loop diuretics have anxiolytic effects in rat models of conditioned anxiety. PLoS One. 2012; 7(4):e35417. PMID: 22514741; PMCID: PMC3325958.
      41. Flink BJ, Rivelli SK, Cox EA, White WD, Falcone G, Vail TP, Young CC, Bolognesi MP, Krystal AD, Trzepacz PT, Moon RE, Kwatra MM. Obstructive sleep apnea and incidence of postoperative delirium after elective knee replacement in the nondemented elderly. Anesthesiology. 2012 Apr; 116(4):788-96. PMID: 22337162; PMCID: PMC3321273.
      42. Krystal AD, Huang H, Zummo J, Grinnell T, Marshall RD. A WASO sub-group analysis of a 6-month study of eszopiclone 3 mg. Sleep Med. 2012 Jun; 13(6):691-6. PMID: 22465450.
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      43. Krystal AD. How the circadian rhythm affects sleep, wakefulness, and overall health: background for understanding shift work disorder. J Clin Psychiatry. 2012 Feb; 73(2):e05. PMID: 22401482.
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      44. Carney CE, Buysse DJ, Ancoli-Israel S, Edinger JD, Krystal AD, Lichstein KL, Morin CM. The consensus sleep diary: standardizing prospective sleep self-monitoring. Sleep. 2012 Feb; 35(2):287-302. PMID: 22294820; PMCID: PMC3250369.
      45. Palmese LB, DeGeorge PC, Ratliff JC, Srihari VH, Wexler BE, Krystal AD, Tek C. Insomnia is frequent in schizophrenia and associated with night eating and obesity. Schizophr Res. 2011 Dec; 133(1-3):238-43. PMID: 21856129.
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      46. Low Y, Preud'homme X, Goforth HW, Omonuwa T, Krystal AD. The association of fatigue with depression and insomnia in HIV-seropositive patients: a pilot study. Sleep. 2011 Dec; 34(12):1723-6. PMID: 22131611; PMCID: PMC3208851.
      47. Krystal AD, Lankford A, Durrence HH, Ludington E, Jochelson P, Rogowski R, Roth T. Efficacy and safety of doxepin 3 and 6 mg in a 35-day sleep laboratory trial in adults with chronic primary insomnia. Sleep. 2011 Oct; 34(10):1433-42. PMID: 21966075; PMCID: PMC3174845.
      48. Rose JE, McClernon FJ, Froeliger B, Behm FM, Preud'homme X, Krystal AD. Repetitive transcranial magnetic stimulation of the superior frontal gyrus modulates craving for cigarettes. Biol Psychiatry. 2011 Oct 15; 70(8):794-9. PMID: 21762878.
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      49. Edinger JD, Wyatt JK, Stepanski EJ, Olsen MK, Stechuchak KM, Carney CE, Chiang A, Crisostomo MI, Lineberger MD, Means MK, Radtke RA, Wohlgemuth WK, Krystal AD. Testing the reliability and validity of DSM-IV-TR and ICSD-2 insomnia diagnoses. Results of a multitrait-multimethod analysis. Arch Gen Psychiatry. 2011 Oct; 68(10):992-1002. PMID: 21646568.
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      50. Carney CE, Moss TG, Harris AL, Edinger JD, Krystal AD. Should we be anxious when assessing anxiety using the Beck Anxiety Inventory in clinical insomnia patients? J Psychiatr Res. 2011 Sep; 45(9):1243-9. PMID: 21482427; PMCID: PMC3157494.
      51. Richey SM, Krystal AD. Pharmacological advances in the treatment of insomnia. Curr Pharm Des. 2011; 17(15):1471-5. PMID: 21476952.
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      52. Krystal AD, Durrence HH, Scharf M, Jochelson P, Rogowski R, Ludington E, Roth T. Efficacy and Safety of Doxepin 1 mg and 3 mg in a 12-week Sleep Laboratory and Outpatient Trial of Elderly Subjects with Chronic Primary Insomnia. Sleep. 2010 Nov; 33(11):1553-61. PMID: 21102997; PMCID: PMC2954705.
      53. Flynn KE, Shelby RA, Mitchell SA, Fawzy MR, Hardy NC, Husain AM, Keefe FJ, Krystal AD, Porter LS, Reeve BB, Weinfurt KP. Sleep-wake functioning along the cancer continuum: focus group results from the Patient-Reported Outcomes Measurement Information System (PROMIS(®)). Psychooncology. 2010 Oct; 19(10):1086-93. PMID: 20013938; PMCID: PMC2888823.
      54. Wilson SJ, Nutt DJ, Alford C, Argyropoulos SV, Baldwin DS, Bateson AN, Britton TC, Crowe C, Dijk DJ, Espie CA, Gringras P, Hajak G, Idzikowski C, Krystal AD, Nash JR, Selsick H, Sharpley AL, Wade AG. British Association for Psychopharmacology consensus statement on evidence-based treatment of insomnia, parasomnias and circadian rhythm disorders. J Psychopharmacol. 2010 Nov; 24(11):1577-601. PMID: 20813762.
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      55. Krystal AD, Zammit GK, Wyatt JK, Quan SF, Edinger JD, White DP, Chiacchierini RP, Malhotra A. The effect of vestibular stimulation in a four-hour sleep phase advance model of transient insomnia. J Clin Sleep Med. 2010 Aug 15; 6(4):315-21. PMID: 20726278; PMCID: PMC2919660.
      56. McCall WV, Blocker JN, D'Agostino R, Kimball J, Boggs N, Lasater B, Haskett R, Krystal A, McDonald WM, Rosenquist PB. Treatment of insomnia in depressed insomniacs: effects on health-related quality of life, objective and self-reported sleep, and depression. J Clin Sleep Med. 2010 Aug 15; 6(4):322-9. PMID: 20726279; PMCID: PMC2919661.
      57. Janicak PG, Nahas Z, Lisanby SH, Solvason HB, Sampson SM, McDonald WM, Marangell LB, Rosenquist P, McCall WV, Kimball J, O'Reardon JP, Loo C, Husain MH, Krystal A, Gilmer W, Dowd SM, Demitrack MA, Schatzberg AF. Durability of clinical benefit with transcranial magnetic stimulation (TMS) in the treatment of pharmacoresistant major depression: assessment of relapse during a 6-month, multisite, open-label study. Brain Stimul. 2010 Oct; 3(4):187-99. PMID: 20965447.
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      58. Krystal AD. In vivo evidence of the specificity of effects of GABA(A) receptor modulating medications. Sleep. 2010 Jul; 33(7):859-60. PMID: 20614842; PMCID: PMC2894424.
      59. Krystal AD, Preud'homme XA, Amundsen CL, Webster GD. Detrusor overactivity persisting at night and preceding nocturia in patients with overactive bladder syndrome: a nocturnal cystometrogram and polysomnogram study. J Urol. 2010 Aug; 184(2):623-8. PMID: 20639027.
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      60. Krystal AD, Edinger JD. Sleep EEG predictors and correlates of the response to cognitive behavioral therapy for insomnia. Sleep. 2010 May; 33(5):669-77. PMID: 20469809; PMCID: PMC2864882.
      61. Ancoli-Israel S, Krystal AD, McCall WV, Schaefer K, Wilson A, Claus R, Rubens R, Roth T. A 12-week, randomized, double-blind, placebo-controlled study evaluating the effect of eszopiclone 2 mg on sleep/wake function in older adults with primary and comorbid insomnia. Sleep. 2010 Feb; 33(2):225-34. PMID: 20175406; PMCID: PMC2817909.
      62. Ohayon MM, Krystal A, Roehrs TA, Roth T, Vitiello MV. Using difficulty resuming sleep to define nocturnal awakenings. Sleep Med. 2010 Mar; 11(3):236-41. PMID: 20075004; PMCID: PMC2830306.
      63. Krystal AD, Harsh JR, Yang R, Yang RR, Rippon GA, Lankford DA. A double-blind, placebo-controlled study of armodafinil for excessive sleepiness in patients with treated obstructive sleep apnea and comorbid depression. J Clin Psychiatry. 2010 Jan; 71(1):32-40. PMID: 20051221.
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      64. Krystal AD. The treatment of primary insomnia. CNS Spectr. 2009 Dec; 14(12 Suppl 13):6-10. PMID: 20448512.
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      65. Omonuwa TS, Goforth HW, Preud'homme X, Krystal AD. The pharmacologic management of insomnia in patients with HIV. J Clin Sleep Med. 2009 Jun 15; 5(3):251-62. PMID: 19960648; PMCID: PMC2699172.
      66. Krystal AD. A compendium of placebo-controlled trials of the risks/benefits of pharmacological treatments for insomnia: the empirical basis for U.S. clinical practice. Sleep Med Rev. 2009 Aug; 13(4):265-74. PMID: 19153052.
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      67. Preud'homme XA, Lanquart JP, Krystal AD, Bogaerts P, Linkowski P. Modeling slow-wave activity dynamics: does an exponentially dampened periodic function really fit a single night of normal human sleep? Clin Neurophysiol. 2008 Dec; 119(12):2753-61. PMID: 18986831.
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      68. Carney CE, Ulmer C, Edinger JD, Krystal AD, Knauss F. Assessing depression symptoms in those with insomnia: an examination of the beck depression inventory second edition (BDI-II). J Psychiatr Res. 2009 Feb; 43(5):576-82. PMID: 18954876; PMCID: PMC2677199.
      69. Krystal AD, Edinger JD. Measuring sleep quality. Sleep Med. 2008 Sep; 9 Suppl 1:S10-7. PMID: 18929313.
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      70. Lisanby SH, Husain MM, Rosenquist PB, Maixner D, Gutierrez R, Krystal A, Gilmer W, Marangell LB, Aaronson S, Daskalakis ZJ, Canterbury R, Richelson E, Sackeim HA, George MS. Daily left prefrontal repetitive transcranial magnetic stimulation in the acute treatment of major depression: clinical predictors of outcome in a multisite, randomized controlled clinical trial. Neuropsychopharmacology. 2009 Jan; 34(2):522-34. PMID: 18704101.
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      71. Krystal AD, Goforth HW, Roth T. Effects of antipsychotic medications on sleep in schizophrenia. Int Clin Psychopharmacol. 2008 May; 23(3):150-60. PMID: 18408529.
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      72. Edinger JD, Means MK, Carney CE, Krystal AD. Psychomotor performance deficits and their relation to prior nights' sleep among individuals with primary insomnia. Sleep. 2008 May; 31(5):599-607. PMID: 18517030; PMCID: PMC2398751.
      73. Pollack M, Kinrys G, Krystal A, McCall WV, Roth T, Schaefer K, Rubens R, Roach J, Huang H, Krishnan R. Eszopiclone coadministered with escitalopram in patients with insomnia and comorbid generalized anxiety disorder. Arch Gen Psychiatry. 2008 May; 65(5):551-62. PMID: 18458207.
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      74. Chiang A, Krystal A. Report of two cases where sleep related eating behavior occurred with the extended-release formulation but not the immediate-release formulation of a sedative-hypnotic agent. J Clin Sleep Med. 2008 Apr 15; 4(2):155-6. PMID: 18468314; PMCID: PMC2335395.
      75. Krystal JH, Carter CS, Geschwind D, Manji HK, March JS, Nestler EJ, Zubieta JK, Charney DS, Goldman D, Gur RE, Lieberman JA, Roy-Byrne P, Rubinow DR, Anderson SA, Barondes S, Berman KF, Blair J, Braff DL, Brown ES, Calabrese JR, Carlezon WA, Cook EH, Davidson RJ, Davis M, Desimone R, Drevets WC, Duman RS, Essock SM, Faraone SV, Freedman R, Friston KJ, Gelernter J, Geller B, Gill M, Gould E, Grace AA, Grillon C, Gueorguieva R, Hariri AR, Innis RB, Jones EG, Kleinman JE, Koob GF, Krystal AD, Leibenluft E, Levinson DF, Levitt PR, Lewis DA, Liberzon I, Lipska BK, Marder SR, Markou A, Mason GF, McDougle CJ, McEwen BS, McMahon FJ, Meaney MJ, Meltzer HY, Merikangas KR, Meyer-Lindenberg A, Mirnics K, Monteggia LM, Neumeister A, O'Brien CP, Owen MJ, Pine DS, Rapoport JL, Rauch SL, Robbins TW, Rosenbaum JF, Rosenberg DR, Ross CA, Rush AJ, Sackeim HA, Sanacora G, Schatzberg AF, Shaham Y, Siever LJ, Sunderland T, Tecott LH, Thase ME, Todd RD, Weissman MM, Yehuda R, Yoshikawa T, Young EA, McCandless R. It is time to take a stand for medical research and against terrorism targeting medical scientists. Biol Psychiatry. 2008 Apr 15; 63(8):725-7. PMID: 18371494.
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      76. Krystal AD, Erman M, Zammit GK, Soubrane C, Roth T. Long-term efficacy and safety of zolpidem extended-release 12.5 mg, administered 3 to 7 nights per week for 24 weeks, in patients with chronic primary insomnia: a 6-month, randomized, double-blind, placebo-controlled, parallel-group, multicenter study. Sleep. 2008 Jan; 31(1):79-90. PMID: 18220081; PMCID: PMC2225552.
      77. Krystal AD, Thakur M, Roth T. Sleep disturbance in psychiatric disorders: effects on function and quality of life in mood disorders, alcoholism, and schizophrenia. Ann Clin Psychiatry. 2008 Jan-Mar; 20(1):39-46. PMID: 18297585.
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      78. Brummett BH, Krystal AD, Ashley-Koch A, Kuhn CM, Züchner S, Siegler IC, Barefoot JC, Ballard EL, Gwyther LP, Williams RB. Sleep quality varies as a function of 5-HTTLPR genotype and stress. Psychosom Med. 2007 Sep-Oct; 69(7):621-4. PMID: 17766685; PMCID: PMC2758820.
      79. Walsh JK, Krystal AD, Amato DA, Rubens R, Caron J, Wessel TC, Schaefer K, Roach J, Wallenstein G, Roth T. Nightly treatment of primary insomnia with eszopiclone for six months: effect on sleep, quality of life, and work limitations. Sleep. 2007 Aug; 30(8):959-68. PMID: 17702264; PMCID: PMC1978384.
      80. Roth T, Krystal AD, Lieberman JA. Long-term issues in the treatment of sleep disorders. CNS Spectr. 2007 Jul; 12(7 Suppl 10):1-14. PMID: 17603408.
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      81. Brummett BH, Krystal AD, Siegler IC, Kuhn C, Surwit RS, Züchner S, Ashley-Koch A, Barefoot JC, Williams RB. Associations of a regulatory polymorphism of monoamine oxidase-A gene promoter (MAOA-uVNTR) with symptoms of depression and sleep quality. Psychosom Med. 2007 Jun; 69(5):396-401. PMID: 17585061; PMCID: PMC2777888.
      82. Lim L, Krystal A. Psychotic disorder in a patient with central and extrapontine myelinolysis. Psychiatry Clin Neurosci. 2007 Jun; 61(3):320-2. PMID: 17472602.
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      83. Krystal AD, Davidson JR. The use of prazosin for the treatment of trauma nightmares and sleep disturbance in combat veterans with post-traumatic stress disorder. Biol Psychiatry. 2007 Apr 15; 61(8):925-7. PMID: 17397667.
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      84. Krystal A, Fava M, Rubens R, Wessel T, Caron J, Wilson P, Roth T, McCall WV. Evaluation of eszopiclone discontinuation after cotherapy with fluoxetine for insomnia with coexisting depression. J Clin Sleep Med. 2007 Feb 15; 3(1):48-55. PMID: 17557453.
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      85. Krystal AD. Treating the health, quality of life, and functional impairments in insomnia. J Clin Sleep Med. 2007 Feb 15; 3(1):63-72. PMID: 17557457.
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      86. Carney CE, Segal ZV, Edinger JD, Krystal AD. A comparison of rates of residual insomnia symptoms following pharmacotherapy or cognitive-behavioral therapy for major depressive disorder. J Clin Psychiatry. 2007 Feb; 68(2):254-60. PMID: 17335324.
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      87. Krystal AD. Sleep and psychiatric disorders: future directions. Psychiatr Clin North Am. 2006 Dec; 29(4):1115-30; abstract xi. PMID: 17118285.
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      88. Zammit GK, Corser B, Doghramji K, Fry JM, James S, Krystal A, Mangano RM. Sleep and residual sedation after administration of zaleplon, zolpidem, and placebo during experimental middle-of-the-night awakening. J Clin Sleep Med. 2006 Oct 15; 2(4):417-23. PMID: 17557470.
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      89. McCall WV, Erman M, Krystal AD, Rosenberg R, Scharf M, Zammit GK, Wessel T. A polysomnography study of eszopiclone in elderly patients with insomnia. Curr Med Res Opin. 2006 Sep; 22(9):1633-42. PMID: 16968566.
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      90. Fava M, McCall WV, Krystal A, Wessel T, Rubens R, Caron J, Amato D, Roth T. Eszopiclone co-administered with fluoxetine in patients with insomnia coexisting with major depressive disorder. Biol Psychiatry. 2006 Jun 1; 59(11):1052-60. PMID: 16581036.
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      91. Walsh JK, Perlis M, Rosenthal M, Krystal A, Jiang J, Roth T. Tiagabine increases slow-wave sleep in a dose-dependent fashion without affecting traditional efficacy measures in adults with primary insomnia. J Clin Sleep Med. 2006 Jan 15; 2(1):35-41. PMID: 17557435.
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      92. Edinger JD, Wohlgemuth WK, Krystal AD, Rice JR. Behavioral insomnia therapy for fibromyalgia patients: a randomized clinical trial. Arch Intern Med. 2005 Nov 28; 165(21):2527-35. PMID: 16314551.
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      93. Roth T, Walsh JK, Krystal A, Wessel T, Roehrs TA. An evaluation of the efficacy and safety of eszopiclone over 12 months in patients with chronic primary insomnia. Sleep Med. 2005 Nov; 6(6):487-95. PMID: 16230048.
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      94. Mccall WV, Perlis ML, Tu X, Groman AE, Krystal A, Walsh JK. A comparison of placebo and no-treatment during a hypnotic clinical trial. Int J Clin Pharmacol Ther. 2005 Aug; 43(8):355-9. PMID: 16119510.
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      95. Krystal AD. The effect of insomnia definitions, terminology, and classifications on clinical practice. J Am Geriatr Soc. 2005 Jul; 53(7 Suppl):S258-63. PMID: 15982374.
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      96. Wohlgemuth WK, Krystal AD. Hypnotics should be considered for the initial treatment of chronic insomnia. Pro. J Clin Sleep Med. 2005 Apr 15; 1(2):120-4. PMID: 17561623.
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      97. Krystal AD. The possibility of preventing functional impairment due to sleep loss by pharmacologically enhancing sleep. Sleep. 2005 Jan; 28(1):16-7. PMID: 15700715.
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      98. Perlis ML, McCall WV, Krystal AD, Walsh JK. Long-term, non-nightly administration of zolpidem in the treatment of patients with primary insomnia. J Clin Psychiatry. 2004 Aug; 65(8):1128-37. PMID: 15323600.
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      99. Singh J, Zarate CA, Krystal AD. Case report: Successful riluzole augmentation therapy in treatment-resistant bipolar depression following the development of rash with lamotrigine. Psychopharmacology (Berl). 2004 Apr; 173(1-2):227-8. PMID: 14722708.
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      100. Krystal AD, Roth T. Introduction: Definitions, measurements, and management in insomnia. J Clin Psychiatry. 2004; 65 Suppl 8:5-7. PMID: 15153061.
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      101. Krystal AD. The changing perspective on chronic insomnia management. J Clin Psychiatry. 2004; 65 Suppl 8:20-5. PMID: 15153064.
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      102. Ancoli-Israel S, Benca RM, Edinger JD, Krystal AD, Mendelson W, Moldofsky H, Petrie J, Roth T, Walsh JK, Winkelman J. Panel discussion: changing how we think about insomnia. J Clin Psychiatry. 2004; 65 Suppl 8:44-6. PMID: 15153067.
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      103. Krystal AD. Depression and insomnia in women. Clin Cornerstone. 2004; 6 Suppl 1B:S19-28. PMID: 15457812.
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      104. Krystal AD, Walsh JK, Laska E, Caron J, Amato DA, Wessel TC, Roth T. Sustained efficacy of eszopiclone over 6 months of nightly treatment: results of a randomized, double-blind, placebo-controlled study in adults with chronic insomnia. Sleep. 2003 Nov 1; 26(7):793-9. PMID: 14655910.
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      105. Edinger JD, Krystal AD. Subtyping primary insomnia: is sleep state misperception a distinct clinical entity? Sleep Med Rev. 2003 Jun; 7(3):203-14. PMID: 12927120.
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      106. Krystal AD. Insomnia in women. Clin Cornerstone. 2003; 5(3):41-50. PMID: 14626540.
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      107. Krystal AD, Weiner RD, Dean MD, Lindahl VH, Tramontozzi LA, Falcone G, Coffey CE. Comparison of seizure duration, ictal EEG, and cognitive effects of ketamine and methohexital anesthesia with ECT. J Neuropsychiatry Clin Neurosci. 2003; 15(1):27-34. PMID: 12556568.
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      108. Krystal AD, Edinger JD, Wohlgemuth WK, Marsh GR. NREM sleep EEG frequency spectral correlates of sleep complaints in primary insomnia subtypes. Sleep. 2002 Sep 15; 25(6):630-40. PMID: 12224842.
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      109. Krystal AD, Ressler I. The use of valerian in neuropsychiatry. CNS Spectr. 2001 Oct; 6(10):841-7. PMID: 15334039.
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      110. Sackeim HA, Devanand DP, Lisanby SH, Nobler MS, Prudic J, Heyer EJ, Ornstein E, Weiner RD, Krystal AD, Coffey CE, Greenberg RM, Husain M, Lite MS, Fernandez P, Gaines GY. Treatment of the modal patient: does one size fit nearly all? J ECT. 2001 Sep; 17(3):219-22. PMID: 11528317.
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      111. Krystal AD, Holsinger T, Weiner RD, Coffey CE. Prediction of the utility of a switch from unilateral to bilateral ECT in the elderly using treatment 2 ictal EEG indices. J ECT. 2000 Dec; 16(4):327-37. PMID: 11314870.
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      112. Krystal AD, Weiner RD, Lindahl V, Massie R. The development and retrospective testing of an electroencephalographic seizure quality-based stimulus dosing paradigm with ECT. J ECT. 2000 Dec; 16(4):338-49. PMID: 11314871.
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      113. Krystal AD, Dean MD, Weiner RD, Tramontozzi LA, Connor KM, Lindahl VH, Massie RW. ECT stimulus intensity: are present ECT devices too limited? Am J Psychiatry. 2000 Jun; 157(6):963-7. PMID: 10831477.
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      114. Krystal AD, West M, Prado R, Greenside H, Zoldi S, Weiner RD. EEG effects of ECT: implications for rTMS. Depress Anxiety. 2000; 12(3):157-65. PMID: 11126190.
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      115. Zoldi SM, Krystal A, Greenside HS. Stationarity and redundancy of multichannel EEG data recorded during generalized tonic-clonic seizures. Brain Topogr. 2000; 12(3):187-200. PMID: 10791682.
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      116. Krystal AD, Prado R, West M. New methods of time series analysis of non-stationary EEG data: eigenstructure decompositions of time varying autoregressions. Clin Neurophysiol. 1999 Dec; 110(12):2197-206. PMID: 10616127.
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      117. Asnis GM, Chakraburtty A, DuBoff EA, Krystal A, Londborg PD, Rosenberg R, Roth-Schechter B, Scharf MB, Walsh JK. Zolpidem for persistent insomnia in SSRI-treated depressed patients. J Clin Psychiatry. 1999 Oct; 60(10):668-76. PMID: 10549683.
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      118. Krystal AD, Weiner RD. EEG correlates of the response to ECT: a possible antidepressant role of brain-derived neurotrophic factor. J ECT. 1999 Mar; 15(1):27-38. PMID: 10189617.
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      119. Krystal AD, Edinger J, Wohlgemuth W, Marsh GR. Sleep in peri-menopausal and post-menopausal women. Sleep Med Rev. 1998 Nov; 2(4):243-53. PMID: 15310495.
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      120. Krystal AD, Watts BV, Weiner RD, Moore S, Steffens DC, Lindahl V. The use of flumazenil in the anxious and benzodiazepine-dependent ECT patient. J ECT. 1998 Mar; 14(1):5-14. PMID: 9661088.
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      121. Krystal AD, Greenside HS. Low-dimensional chaos in bipolar disorder? Arch Gen Psychiatry. 1998 Mar; 55(3):275-6. PMID: 9510223.
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      122. Krystal AD, Coffey CE, Weiner RD, Holsinger T. Changes in seizure threshold over the course of electroconvulsive therapy affect therapeutic response and are detected by ictal EEG ratings. J Neuropsychiatry Clin Neurosci. 1998; 10(2):178-86. PMID: 9608406.
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      123. Krystal AD, Zaidman C, Greenside HS, Weiner RD, Coffey CE. The largest Lyapunov exponent of the EEG during ECT seizures as a measure of ECT seizure adequacy. Electroencephalogr Clin Neurophysiol. 1997 Dec; 103(6):599-606. PMID: 9546486.
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      124. Krystal A, Carr J, Gavaghan K, Porterfield P, Turner L. Implementing a hospital-wide pain management strategy. Can J Nurs Adm. 1997 Sep; 10(3):74-89. PMID: 9355286.
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      125. Krystal AD, Coffey CE. Neuropsychiatric considerations in the use of electroconvulsive therapy. J Neuropsychiatry Clin Neurosci. 1997; 9(2):283-92. PMID: 9144111.
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      126. Krystal AD, Greenside HS, Weiner RD, Gassert D. A comparison of EEG signal dynamics in waking, after anesthesia induction and during electroconvulsive therapy seizures. Electroencephalogr Clin Neurophysiol. 1996 Aug; 99(2):129-40. PMID: 8761049.
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      127. Edinger JD, Fins AI, Goeke JM, McMillan DK, Gersh TL, Krystal AD, McCall WV. The empirical identification of insomnia subtypes: a cluster analytic approach. Sleep. 1996 Jun; 19(5):398-411. PMID: 8843531.
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      128. Krystal AD, Weiner RD, Coffey CE, McCall WV. Effect of ECT treatment number on the ictal EEG. Psychiatry Res. 1996 May 17; 62(2):179-89. PMID: 8771615.
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      129. Krystal AD, Weiner RD, Gassert D, McCall WV, Coffey CE, Sibert T, Holsinger T. The relative ability of three ictal EEG frequency bands to differentiate ECT seizures on the basis of electrode placement, stimulus intensity, and therapeutic response. Convuls Ther. 1996 Mar; 12(1):13-24. PMID: 8777648.
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      130. Steffens DC, Krystal AD, Sibert TE, Moore SD, Weiner RD. Cost effectiveness of maintenance ECT. Convuls Ther. 1995 Dec; 11(4):283-4. PMID: 8919583.
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      131. Krystal AD, Weiner RD. ECT seizure duration: reliability of manual and computer-automated determinations. Convuls Ther. 1995 Sep; 11(3):158-69. PMID: 8528657.
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      132. Coffey CE, Lucke J, Weiner RD, Krystal AD, Aque M. Seizure threshold in electroconvulsive therapy (ECT) II. The anticonvulsant effect of ECT. Biol Psychiatry. 1995 Jun 1; 37(11):777-88. PMID: 7647162.
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      133. Coffey CE, Lucke J, Weiner RD, Krystal AD, Aque M. Seizure threshold in electroconvulsive therapy: I. Initial seizure threshold. Biol Psychiatry. 1995 May 15; 37(10):713-20. PMID: 7640326.
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      134. Edinger JD, Erwin CW, Fins AI, Marsh GR, Krystal AD. Ambulatory cassette polysomnography: findings from a large cohort of drug-free insomnia patients. J Clin Neurophysiol. 1995 May; 12(3):302-9. PMID: 11221789.
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      135. Krystal AD, Weiner RD, Coffey CE. The ictal EEG as a marker of adequate stimulus intensity with unilateral ECT. J Neuropsychiatry Clin Neurosci. 1995; 7(3):295-303. PMID: 7580187.
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      136. Krystal AD, Weiner RD. ECT seizure therapeutic adequacy. Convuls Ther. 1994 Jun; 10(2):153-64. PMID: 8069641.
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      137. Weiner RD, Krystal AD. The present use of electroconvulsive therapy. Annu Rev Med. 1994; 45:273-81. PMID: 8198383.
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      138. Krystal AD, Weiner RD, McCall WV, Shelp FE, Arias R, Smith P. The effects of ECT stimulus dose and electrode placement on the ictal electroencephalogram: an intraindividual crossover study. Biol Psychiatry. 1993 Dec 1; 34(11):759-67. PMID: 8292679.
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      139. Krystal AD, Weiner RD, Coffey CE, Smith P, Arias R, Moffett E. EEG evidence of more "intense" seizure activity with bilateral ECT. Biol Psychiatry. 1992 Mar 15; 31(6):617-21. PMID: 1581442.
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      140. McCall WV, Erwin CW, Edinger JD, Krystal AD, Marsh GR. Ambulatory polysomnography: technical aspects and normative values. J Clin Neurophysiol. 1992 Jan; 9(1):68-77. PMID: 1552010.
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      141. Weiner RD, Krystal AD, Coffey CE, Smith P. The electrophysiology of ECT: relevance to mechanism of action. Clin Neuropharmacol. 1992; 15 Suppl 1 Pt A:671A-672A. PMID: 1498995.
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      142. Weiner RD, Coffey CE, Krystal AD. The monitoring and management of electrically induced seizures. Psychiatr Clin North Am. 1991 Dec; 14(4):845-69. PMID: 1771151.
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      143. Krystal AD, McEvoy JP. Shared features of neuroleptic malignant syndrome and alcohol abuse complications. J Clin Psychiatry. 1990 Dec; 51(12):523. PMID: 2258367.
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      144. Krystal A, Krishnan KR, Raitiere M, Poland R, Ritchie JC, Dunnick NR, Hanada K, Nemeroff CB. Differential diagnosis and pathophysiology of Cushing's syndrome and primary affective disorder. J Neuropsychiatry Clin Neurosci. 1990; 2(1):34-43. PMID: 1967010.
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