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Michael Gropper, MD, PhD

TitleProfessor
SchoolUCSF School of Medicine
DepartmentAnesthesia
Address500 Parnassus Avenue
San Francisco CA 94117
Phone415-476-6771
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    Collapse Biography 
    Collapse education and training
    University of California, San Francisco Residency School of Medicine
    University of California Los AngelesM.D.1989School of Medicine
    University of California, San FranciscoPh.D.1985 Graduate Division (Physiology)
    Collapse awards and honors
    Harvard Medical School20133rd Henning Pontoppidan Lecture

    Collapse Overview 
    Collapse overview
    Professor and Chair
    Department of Anesthesia and Perioperative Care


    Collapse ORNG Applications 
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    Collapse In The News
    Collapse Clinical Trials
    Collapse Global Health
    Collapse Featured Videos

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Gross K, Schwarz J, Khanna R, Schell-Chaple H, Gropper M, Lipshutz A, Aldrich M. 1198: TARGET RASS: AN EXAMPLE OF LEVERAGING THE EHR TO STANDARDIZE GOAL-BASED INTERVENTIONS. Crit Care Med. 2016 Dec; 44(12 Suppl 1):375. PMID: 27850834.
      View in: PubMed
    2. Detsky AS, Gropper MA. Why Physician Leaders of Health Care Organizations Should Participate in Direct Patient Care. Ann Intern Med. 2016 Oct 4; 165(7):519-520. PMID: 27399305.
      View in: PubMed
    3. Vacas S, McInrue E, Gropper MA, Maze M, Zak R, Lim E, Leung JM. The Feasibility and Utility of Continuous Sleep Monitoring in Critically Ill Patients Using a Portable Electroencephalography Monitor. Anesth Analg. 2016 Jul; 123(1):206-12. PMID: 27159066.
      View in: PubMed
    4. Lipshutz AK, Feiner JR, Grimes B, Gropper MA. Predicting mortality in the intensive care unit: a comparison of the University Health Consortium expected probability of mortality and the Mortality Prediction Model III. J Intensive Care. 2016; 4:35. PMID: 27217959.
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    5. Lipshutz AK, Gropper MA. Intensive Care Unit-acquired Muscle Weakness: An Ounce of Prevention Is Worth a Pound of Cure. Anesthesiology. 2016 Jan; 124(1):7-9. PMID: 26448468.
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    6. Crowley JC, Gropper MA. IV Immunoglobulin: A Useful Tool for the Severe Pneumonia Toolbox? Crit Care Med. 2016 Jan; 44(1):250-1. PMID: 26672937.
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    7. Paradis E, Leslie M, Gropper MA. Interprofessional rhetoric and operational realities: an ethnographic study of rounds in four intensive care units. Adv Health Sci Educ Theory Pract. 2016 Oct; 21(4):735-48. PMID: 26704051.
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    8. Feiner JR, Gropper MA, Toy P, Lieberman J, Twiford J, Weiskopf RB. A Clinical Trial to Detect Subclinical Transfusion-induced Lung Injury during Surgery. Anesthesiology. 2015 Jul; 123(1):126-35. PMID: 25946480; PMCID: PMC4626309 [Available on 07/01/16].
    9. Lipshutz AK, Caldwell JE, Robinowitz DL, Gropper MA. An analysis of near misses identified by anesthesia providers in the intensive care unit. BMC Anesthesiol. 2015; 15:93. PMID: 26082147; PMCID: PMC4468961.
    10. Roubinian NH, Looney MR, Kor DJ, Lowell CA, Gajic O, Hubmayr RD, Gropper MA, Koenigsberg M, Wilson GA, Matthay MA, Toy P, Murphy EL. Cytokines and clinical predictors in distinguishing pulmonary transfusion reactions. Transfusion. 2015 Aug; 55(8):1838-46. PMID: 25702590; PMCID: PMC4536135 [Available on 08/01/16].
    11. Toy P, Bacchetti P, Grimes B, Gajic O, Murphy EL, Winters JL, Gropper MA, Hubmayr RD, Matthay MA, Wilson G, Koenigsberg M, Lee DC, Hirschler NV, Lowell CA, Schuller RM, Gandhi MJ, Norris PJ, Mair DC, Sanchez Rosen R, Looney MR. Recipient clinical risk factors predominate in possible transfusion-related acute lung injury. Transfusion. 2015 May; 55(5):947-52. PMID: 25488517; PMCID: PMC4428945 [Available on 05/01/16].
    12. Looney MR, Roubinian N, Gajic O, Gropper MA, Hubmayr RD, Lowell CA, Bacchetti P, Wilson G, Koenigsberg M, Lee DC, Wu P, Grimes B, Norris PJ, Murphy EL, Gandhi MJ, Winters JL, Mair DC, Schuller RM, Hirschler NV, Rosen RS, Matthay MA, Toy P. Prospective study on the clinical course and outcomes in transfusion-related acute lung injury*. Crit Care Med. 2014 Jul; 42(7):1676-87. PMID: 24776608; PMCID: PMC4284060.
    13. Paradis E, Leslie M, Puntillo K, Gropper M, Aboumatar HJ, Kitto S, Reeves S. Delivering interprofessional care in intensive care: a scoping review of ethnographic studies. Am J Crit Care. 2014 May; 23(3):230-8. PMID: 24786811.
      View in: PubMed
    14. Gilliss BM, Gropper MA. Say no to old blood*. Crit Care Med. 2013 Nov; 41(11):2648-9. PMID: 24162678.
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    15. Leslie M, Paradis E, Gropper MA, Reeves S, Kitto S. Applying ethnography to the study of context in healthcare quality and safety. BMJ Qual Saf. 2014 Feb; 23(2):99-105. PMID: 24096894.
      View in: PubMed
    16. Engel HJ, Needham DM, Morris PE, Gropper MA. ICU early mobilization: from recommendation to implementation at three medical centers. Crit Care Med. 2013 Sep; 41(9 Suppl 1):S69-80. PMID: 23989097.
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    17. Paradis E, Leslie M, Gropper MA, Aboumatar HJ, Kitto S, Reeves S. Interprofessional care in intensive care settings and the factors that impact it: results from a scoping review of ethnographic studies. J Crit Care. 2013 Dec; 28(6):1062-7. PMID: 23890936.
      View in: PubMed
    18. Paradis E, Reeves S, Leslie M, Aboumatar H, Chesluk B, Clark P, Courtenay M, Franck L, Lamb G, Lyndon A, Mesman J, Puntillo K, Schmitt M, van Soeren M, Wachter B, Zwarenstein M, Gropper M, Kitto S. Exploring the nature of interprofessional collaboration and family member involvement in an intensive care context. J Interprof Care. 2014 Jan; 28(1):74-5. PMID: 23672585.
      View in: PubMed
    19. Gropper MA. Postoperative respiratory muscle dysfunction: only the strong survive. Anesthesiology. 2013 Apr; 118(4):783-4. PMID: 23386178.
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    20. Murphy EL, Kwaan N, Looney MR, Gajic O, Hubmayr RD, Gropper MA, Koenigsberg M, Wilson G, Matthay M, Bacchetti P, Toy P. Risk factors and outcomes in transfusion-associated circulatory overload. Am J Med. 2013 Apr; 126(4):357.e29-38. PMID: 23357450; PMCID: PMC3652681.
    21. Lipshutz AK, Gropper MA. Acquired neuromuscular weakness and early mobilization in the intensive care unit. Anesthesiology. 2013 Jan; 118(1):202-15. PMID: 22929731.
      View in: PubMed
    22. Puntillo KA, Neuhaus J, Arai S, Paul SM, Gropper MA, Cohen NH, Miaskowski C. Challenge of assessing symptoms in seriously ill intensive care unit patients: can proxy reporters help? Crit Care Med. 2012 Oct; 40(10):2760-7. PMID: 22890258; PMCID: PMC3712644.
    23. Lipshutz AK, Gropper MA. Central venous catheters: follow the evidence, not the guidelines. Crit Care Med. 2012 Aug; 40(8):2528-9. PMID: 22809938.
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    24. Toossi S, Lomen-Hoerth C, Josephson SA, Gropper MA, Roberts J, Patton K, Smith WS. Organ donation after cardiac death in amyotrophic lateral sclerosis. Ann Neurol. 2012 Feb; 71(2):154-6. PMID: 22334377.
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    25. Weiskopf RB, Feiner J, Toy P, Twiford J, Shimabukuro D, Lieberman J, Looney MR, Lowell CA, Gropper MA. Fresh and stored red blood cell transfusion equivalently induce subclinical pulmonary gas exchange deficit in normal humans. Anesth Analg. 2012 Mar; 114(3):511-9. PMID: 22262647; PMCID: PMC3927839.
    26. Toy P, Gajic O, Bacchetti P, Looney MR, Gropper MA, Hubmayr R, Lowell CA, Norris PJ, Murphy EL, Weiskopf RB, Wilson G, Koenigsberg M, Lee D, Schuller R, Wu P, Grimes B, Gandhi MJ, Winters JL, Mair D, Hirschler N, Sanchez Rosen R, Matthay MA. Transfusion-related acute lung injury: incidence and risk factors. Blood. 2012 Feb 16; 119(7):1757-67. PMID: 22117051; PMCID: PMC3286351.
    27. Gilliss BM, Looney MR, Gropper MA. Reducing noninfectious risks of blood transfusion. Anesthesiology. 2011 Sep; 115(3):635-49. PMID: 21792054; PMCID: PMC3162102.
    28. Donovan AL, Gropper MA. Prediction is very difficult, especially about the future-Niels Bohr. Crit Care Med. 2011 Aug; 39(8):2005-7. PMID: 21768809.
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    29. Razonable RR, Findlay JY, O'Riordan A, Burroughs SG, Ghobrial RM, Agarwal B, Davenport A, Gropper M. Critical care issues in patients after liver transplantation. Liver Transpl. 2011 May; 17(5):511-27. PMID: 21384524.
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    30. Puntillo KA, Arai S, Cohen NH, Gropper MA, Neuhaus J, Paul SM, Miaskowski C. Symptoms experienced by intensive care unit patients at high risk of dying. Crit Care Med. 2010 Nov; 38(11):2155-60. PMID: 20711069; PMCID: PMC3377582.
    31. Liu LL, Aldrich JM, Shimabukuro DW, Sullivan KR, Taylor JM, Thornton KC, Gropper MA. Special article: rescue therapies for acute hypoxemic respiratory failure. Anesth Analg. 2010 Sep; 111(3):693-702. PMID: 20624836.
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    32. Aldrich JM, Gropper MA. Can we predict pulmonary complications after thoracic surgery? Anesth Analg. 2010 May 1; 110(5):1261-3. PMID: 20418289.
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    33. Josephson SA, Moheet AM, Gropper MA, Nichols AD, Smith WS. Ventilator-associated pneumonia in a neurologic intensive care unit does not lead to increased mortality. Neurocrit Care. 2010 Apr; 12(2):155-8. PMID: 19806474.
      View in: PubMed
    34. Ong MK, Mangione CM, Romano PS, Zhou Q, Auerbach AD, Chun A, Davidson B, Ganiats TG, Greenfield S, Gropper MA, Malik S, Rosenthal JT, Escarce JJ. Looking forward, looking back: assessing variations in hospital resource use and outcomes for elderly patients with heart failure. Circ Cardiovasc Qual Outcomes. 2009 Nov; 2(6):548-57. PMID: 20031892; PMCID: PMC2951887.
    35. Savel RH, Goldstein EB, Gropper MA. Critical care checklists, the Keystone Project, and the Office for Human Research Protections: a case for streamlining the approval process in quality-improvement research. Crit Care Med. 2009 Feb; 37(2):725-8. PMID: 19114910.
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    36. Lipshutz AK, Gropper MA. Perioperative glycemic control: an evidence-based review. Anesthesiology. 2009 Feb; 110(2):408-21. PMID: 19194167.
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    37. Shimabukuro DW, Gropper MA. Noisy mechanical ventilation: listen to the melody. Anesthesiology. 2009 Feb; 110(2):214-5. PMID: 19194146.
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    38. Hlava N, Niemann CU, Gropper MA, Melcher ML. Postoperative infectious complications of abdominal solid organ transplantation. J Intensive Care Med. 2009 Jan-Feb; 24(1):3-17. PMID: 19017663.
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    39. Sullivan K, Gropper MA. Laboratory testing guidelines in the intensive care unit: less red and more green. Crit Care Med. 2008 Nov; 36(11):3102-3. PMID: 18941313.
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    40. Lipshutz AK, Fee C, Schell H, Campbell L, Taylor J, Sharpe BA, Nguyen J, Gropper MA. Strategies for success: A PDSA analysis of three QI initiatives in critical care. Jt Comm J Qual Patient Saf. 2008 Aug; 34(8):435-44. PMID: 18714744.
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    41. Yost CS, Gropper MA. The curse of the drinking class. Crit Care Med. 2008 Jun; 36(6):1958-9. PMID: 18520650.
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    42. Liu L, Gropper MA. Tracheostomy protocol compliance: herding cats? Crit Care Med. 2008 Jun; 36(6):1959-60. PMID: 18520651.
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    43. Gropper MA, Wiener-Kronish J. The epithelium in acute lung injury/acute respiratory distress syndrome. Curr Opin Crit Care. 2008 Feb; 14(1):11-5. PMID: 18195620.
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    44. Gropper MA. Multisystem organ failure: predicting the future. Anesthesiology. 2007 Jul; 107(1):6-7. PMID: 17585208.
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    45. Taylor JM, Gropper MA. Critical care challenges in orthopedic surgery patients. Crit Care Med. 2006 Sep; 34(9 Suppl):S191-9. PMID: 16917423.
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    46. Gajic O, Gropper MA, Hubmayr RD. Pulmonary edema after transfusion: how to differentiate transfusion-associated circulatory overload from transfusion-related acute lung injury. Crit Care Med. 2006 May; 34(5 Suppl):S109-13. PMID: 16617253.
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    47. Niemann CU, Behrends M, Quan D, Eilers H, Gropper MA, Roberts JP, Hirose R. Recombinant factor VIIa reduces transfusion requirements in liver transplant patients with high MELD scores. Transfus Med. 2006 Apr; 16(2):93-100. PMID: 16623915.
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    48. Fee C, Gropper MA. Establishing a comprehensive, evidence-based protocol for the care of patients with sepsis. Acad Emerg Med. 2005 Sep; 12(9):912-3; author reply 914. PMID: 16141030.
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    49. Guglielmo BJ, Dudas V, Maewal I, Young R, Hilts A, Villmann M, Gibbs L, Gropper M, Jacobs R. Impact of a series of interventions in vancomycin prescribing on use and prevalence of vancomycin-resistant enterococci. Jt Comm J Qual Patient Saf. 2005 Aug; 31(8):469-75. PMID: 16156195.
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    50. Gropper MA. Evidence-based management of critically ill patients: analysis and implementation. Anesth Analg. 2004 Aug; 99(2):566-72. PMID: 15271740.
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    51. Looney MR, Gropper MA, Matthay MA. Transfusion-related acute lung injury: a review. Chest. 2004 Jul; 126(1):249-58. PMID: 15249468.
      View in: PubMed
    52. Gropper MA, Matthay MA. Look before you leap: how do intensivists improve care for critically ill patients? Am J Med. 2004 Feb 1; 116(3):206-7. PMID: 14749169.
      View in: PubMed
    53. Gropper MA. Sepsis and hypothermia: call in the granulocytes? Anesthesiology. 2003 Nov; 99(5):1041-3. PMID: 14576534.
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    54. Shimabukuro DW, Sawa T, Gropper MA. Injury and repair in lung and airways. Crit Care Med. 2003 Aug; 31(8 Suppl):S524-31. PMID: 12907882.
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    55. Misset B, Gropper MA, Wiener-Kronish JP. Predicting mortality in acute respiratory distress syndrome: circulatory system knows best. Crit Care Med. 2003 Mar; 31(3):980-1. PMID: 12627020.
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    56. Gropper MA, Wiener-Kronish J. The alveolar epithelium: suspect or innocent bystander? Anesthesiology. 2003 Jan; 98(1):3-4. PMID: 12502970.
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    57. Liu LL, Gropper MA. Postoperative analgesia and sedation in the adult intensive care unit: a guide to drug selection. Drugs. 2003; 63(8):755-67. PMID: 12662124.
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    58. Gropper MA. A momentary pause... Br J Anaesth. 2001 Jun; 86(6):746-9. PMID: 11573578.
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    59. Savel RH, Yao EC, Gropper MA. Protective effects of low tidal volume ventilation in a rabbit model of Pseudomonas aeruginosa-induced acute lung injury. Crit Care Med. 2001 Feb; 29(2):392-8. PMID: 11246322.
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    60. Yost CS, Matthay MA, Gropper MA. Etiology of acute pulmonary edema during liver transplantation : a series of cases with analysis of the edema fluid. Chest. 2001 Jan; 119(1):219-23. PMID: 11157607.
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    61. Kindler CH, Verotta D, Gray AT, Gropper MA, Yost CS. Additive inhibition of nicotinic acetylcholine receptors by corticosteroids and the neuromuscular blocking drug vecuronium. Anesthesiology. 2000 Mar; 92(3):821-32. PMID: 10719961.
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    62. Kurahashi K, Kajikawa O, Sawa T, Ohara M, Gropper MA, Frank DW, Martin TR, Wiener-Kronish JP. Pathogenesis of septic shock in Pseudomonas aeruginosa pneumonia. J Clin Invest. 1999 Sep; 104(6):743-50. PMID: 10491409; PMCID: PMC408437.
    63. Sawa T, Yahr TL, Ohara M, Kurahashi K, Gropper MA, Wiener-Kronish JP, Frank DW. Active and passive immunization with the Pseudomonas V antigen protects against type III intoxication and lung injury. Nat Med. 1999 Apr; 5(4):392-8. PMID: 10202927.
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    64. Sawa T, Kurahashi K, Ohara M, Gropper MA, Doshi V, Larrick JW, Wiener-Kronish JP. Evaluation of antimicrobial and lipopolysaccharide-neutralizing effects of a synthetic CAP18 fragment against Pseudomonas aeruginosa in a mouse model. Antimicrob Agents Chemother. 1998 Dec; 42(12):3269-75. PMID: 9835525; PMCID: PMC106033.
    65. Sawa T, Ohara M, Kurahashi K, Twining SS, Frank DW, Doroques DB, Long T, Gropper MA, Wiener-Kronish JP. In vitro cellular toxicity predicts Pseudomonas aeruginosa virulence in lung infections. Infect Immun. 1998 Jul; 66(7):3242-9. PMID: 9632591; PMCID: PMC108338.
    66. Wiener-Kronish JP, Gropper MA. Halogenated anesthetics and the injured lung: clouds on the horizon? Anesthesiology. 1998 Jun; 88(6):1435-6. PMID: 9637634.
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    67. Ohara M, Sawa T, Kurahashi K, Wiener-Kronish JP, Doshi V, Kudoh I, Gropper MA. Induction of cyclooxygenase-2 in alveolar macrophages after acid aspiration: selective cyclooxygenase-2 blockade reduces interleukin-6 production. Anesthesiology. 1998 Apr; 88(4):1014-22. PMID: 9579511.
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    68. Sawa T, Corry DB, Gropper MA, Ohara M, Kurahashi K, Wiener-Kronish JP. IL-10 improves lung injury and survival in Pseudomonas aeruginosa pneumonia. J Immunol. 1997 Sep 15; 159(6):2858-66. PMID: 9300709.
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    69. Umenishi F, Verkman AS, Gropper MA. Quantitative analysis of aquaporin mRNA expression in rat tissues by RNase protection assay. DNA Cell Biol. 1996 Jun; 15(6):475-80. PMID: 8672243.
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    70. Sawa T, Miyazaki H, Pittet JF, Widdicombe JH, Gropper MA, Hashimoto S, Conrad DJ, Folkesson HG, Debs R, Forsayeth JR, Fox B, Wiener-Kronish JP. Intraluminal water increases expression of plasmid DNA in rat lung. Hum Gene Ther. 1996 May 20; 7(8):933-41. PMID: 8727507.
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    71. Frigeri A, Gropper MA, Umenishi F, Kawashima M, Brown D, Verkman AS. Localization of MIWC and GLIP water channel homologs in neuromuscular, epithelial and glandular tissues. J Cell Sci. 1995 Sep; 108 ( Pt 9):2993-3002. PMID: 8537439.
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    72. Frigeri A, Gropper MA, Turck CW, Verkman AS. Immunolocalization of the mercurial-insensitive water channel and glycerol intrinsic protein in epithelial cell plasma membranes. Proc Natl Acad Sci U S A. 1995 May 9; 92(10):4328-31. PMID: 7538665; PMCID: PMC41937.
    73. Gropper MA, Wiener-Kronish JP, Hashimoto S. Acute cardiogenic pulmonary edema. Clin Chest Med. 1994 Sep; 15(3):501-15. PMID: 7982344.
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    74. Raj JU, Hillyard R, Kaapa P, Anderson J, Gropper M. Pulmonary vascular pressure profile in 2-3-week-old, 5-6-week-old and adult ferrets. Respir Physiol. 1990 Dec; 82(3):307-15. PMID: 2080320.
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    75. Raj JU, Hillyard R, Kaapa P, Gropper M, Anderson J. Pulmonary arterial and venous constriction during hypoxia in 3- to 5-wk-old and adult ferrets. J Appl Physiol (1985). 1990 Dec; 69(6):2183-9. PMID: 2077015.
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    76. Wiener-Kronish JP, Gropper M, Matthay MA. The adult respiratory distress syndrome: definition and prognosis, pathogenesis and treatment. Br J Anaesth. 1990 Jul; 65(1):107-29. PMID: 2200479.
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    77. Tanita T, Gropper M, Staub NC, Koike K, Nakada T. [Estimation of the filtration variables in the rat lung]. Nihon Kyobu Shikkan Gakkai Zasshi. 1989 Oct; 27(10):1168-72. PMID: 2615069.
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    78. Bhattacharya J, Gropper M, Shepard JM. Lung expansion and the perialveolar interstitial pressure gradient. J Appl Physiol (1985). 1989 Jun; 66(6):2600-5. PMID: 2745322.
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    79. Wiener-Kronish JP, Broaddus VC, Albertine KH, Gropper M, Matthay MA, Staub NC. Relationship of pleural effusions to increased permeability pulmonary edema in anesthetized sheep. J Clin Invest. 1988 Oct; 82(4):1422-9. PMID: 3170750; PMCID: PMC442700.
    80. Berthiaume Y, Broaddus VC, Gropper M, Tanita T, Matthay MA. Alveolar liquid and protein clearance from normal dog lungs. J Appl Physiol (1985). 1988 Aug; 65(2):585-93. PMID: 3170409.
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    81. Gropper MA, Bhattacharya J, Staub NC. Filtration profile in isolated zone 1 and zone 3 dog lungs at constant high alveolar pressure. J Appl Physiol (1985). 1988 Jul; 65(1):343-9. PMID: 3403479.
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    82. Shepard JM, Gropper MA, Nicolaysen G, Staub NC, Bhattacharya J. Lung microvascular pressure profile measured by micropuncture in anesthetized dogs. J Appl Physiol (1985). 1988 Feb; 64(2):874-9. PMID: 3372444.
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    83. Findell PR, Mulchahey JJ, Shepard JM, Gropper MA, Battacharya J, Weiner RI. Direct measurement of blood pressure within the long hypophysial portal blood vessels. Neuroendocrinology. 1987 Apr; 45(4):263-6. PMID: 3574605.
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    84. Wiener-Kronish JP, Gropper MA, Lai-Fook SJ. Pleural liquid pressure in dogs measured using a rib capsule. J Appl Physiol (1985). 1985 Aug; 59(2):597-602. PMID: 4030612.
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    85. Bhattacharya J, Gropper MA, Staub NC. Interstitial fluid pressure gradient measured by micropuncture in excised dog lung. J Appl Physiol Respir Environ Exerc Physiol. 1984 Feb; 56(2):271-7. PMID: 6706738.
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    86. Nagasaka Y, Bhattacharya J, Nanjo S, Gropper MA, Staub NC. Micropuncture measurement of lung microvascular pressure profile during hypoxia in cats. Circ Res. 1984 Jan; 54(1):90-5. PMID: 6692501.
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    87. Conhaim RL, Gropper MA, Staub NC. Effect of lung inflation on alveolar-airway barrier protein permeability in dog lung. J Appl Physiol Respir Environ Exerc Physiol. 1983 Oct; 55(4):1249-56. PMID: 6629958.
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