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    Last Name
    Institution

    Robert Edwards, MD

    TitleProfessor
    SchoolUCSF School of Medicine
    DepartmentNeurology
    Address600 16th Street
    San Francisco CA 94158
    Phone415-502-5687

       Bibliographic 
       Publications
      Publications by year:
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      1. Michalski D, Härtig W, Krügel K, Edwards RH, Böddener M, Böhme L, Pannicke T, Reichenbach A, Grosche A. Region-specific expression of vesicular glutamate and GABA transporters under various ischaemic conditions in mouse forebrain and retina. Neuroscience. 2013 Feb 12; 231:328-44.
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      2. Hnasko TS, Hjelmstad GO, Fields HL, Edwards RH. Ventral tegmental area glutamate neurons: electrophysiological properties and projections. J Neurosci. 2012 Oct 24; 32(43):15076-85.
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      3. Akil O, Seal RP, Burke K, Wang C, Alemi A, During M, Edwards RH, Lustig LR. Restoration of hearing in the VGLUT3 knockout mouse using virally mediated gene therapy. Neuron. 2012 Jul 26; 75(2):283-93.
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      4. Cunningham KA, Hua Z, Srinivasan S, Liu J, Lee BH, Edwards RH, Ashrafi K. AMP-activated kinase links serotonergic signaling to glutamate release for regulation of feeding behavior in C. elegans. Cell Metab. 2012 Jul 3; 16(1):113-21.
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      5. Wu S, Avila-Sakar A, Kim J, Booth DS, Greenberg CH, Rossi A, Liao M, Li X, Alian A, Griner SL, Juge N, Yu Y, Mergel CM, Chaparro-Riggers J, Strop P, Tampé R, Edwards RH, Stroud RM, Craik CS, Cheng Y. Fabs enable single particle cryoEM studies of small proteins. Structure. 2012 Apr 4; 20(4):582-92.
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      6. Blakely RD, Edwards RH. Vesicular and plasma membrane transporters for neurotransmitters. Cold Spring Harb Perspect Biol. 2012 Feb; 4(2).
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      7. Lee HY, Nakayama J, Xu Y, Fan X, Karouani M, Shen Y, Pothos EN, Hess EJ, Fu YH, Edwards RH, Ptácek LJ. Dopamine dysregulation in a mouse model of paroxysmal nonkinesigenic dyskinesia. J Clin Invest. 2012 Feb 1; 122(2):507-18.
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      8. Lee HY, Huang Y, Bruneau N, Roll P, Roberson ED, Hermann M, Quinn E, Maas J, Edwards R, Ashizawa T, Baykan B, Bhatia K, Bressman S, Bruno MK, Brunt ER, Caraballo R, Echenne B, Fejerman N, Frucht S, Gurnett CA, Hirsch E, Houlden H, Jankovic J, Lee WL, Lynch DR, Mohammed S, Müller U, Nespeca MP, Renner D, Rochette J, Rudolf G, Saiki S, Soong BW, Swoboda KJ, Tucker S, Wood N, Hanna M, Bowcock AM, Szepetowski P, Fu YH, Ptácek LJ. Mutations in the gene PRRT2 cause paroxysmal kinesigenic dyskinesia with infantile convulsions. Cell Rep. 2012 Jan 26; 1(1):2-12.
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      9. Brumovsky PR, Robinson DR, La JH, Seroogy KB, Lundgren KH, Albers KM, Kiyatkin ME, Seal RP, Edwards RH, Watanabe M, Hökfelt T, Gebhart GF. Expression of vesicular glutamate transporters type 1 and 2 in sensory and autonomic neurons innervating the mouse colorectum. J Comp Neurol. 2011 Nov 1; 519(16):3346-66.
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      10. Hnasko TS, Edwards RH. Neurotransmitter corelease: mechanism and physiological role. Annu Rev Physiol. 2012; 74:225-43.
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      11. Goh GY, Huang H, Ullman J, Borre L, Hnasko TS, Trussell LO, Edwards RH. Presynaptic regulation of quantal size: K+/H+ exchange stimulates vesicular glutamate transport. Nat Neurosci. 2011 Oct; 14(10):1285-92.
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      12. Grimes WN, Seal RP, Oesch N, Edwards RH, Diamond JS. Genetic targeting and physiological features of VGLUT3+ amacrine cells. Vis Neurosci. 2011 Sep; 28(5):381-92.
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      13. Hua Z, Leal-Ortiz S, Foss SM, Waites CL, Garner CC, Voglmaier SM, Edwards RH. v-SNARE composition distinguishes synaptic vesicle pools. Neuron. 2011 Aug 11; 71(3):474-87.
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      14. Koch SM, Dela Cruz CG, Hnasko TS, Edwards RH, Huberman AD, Ullian EM. Pathway-specific genetic attenuation of glutamate release alters select features of competition-based visual circuit refinement. Neuron. 2011 Jul 28; 71(2):235-42.
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      15. Higley MJ, Gittis AH, Oldenburg IA, Balthasar N, Seal RP, Edwards RH, Lowell BB, Kreitzer AC, Sabatini BL. Cholinergic interneurons mediate fast VGluT3-dependent glutamatergic transmission in the striatum. PLoS One. 2011; 6(4):e19155.
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      16. Nakamura K, Nemani VM, Azarbal F, Skibinski G, Levy JM, Egami K, Munishkina L, Zhang J, Gardner B, Wakabayashi J, Sesaki H, Cheng Y, Finkbeiner S, Nussbaum RL, Masliah E, Edwards RH. Direct membrane association drives mitochondrial fission by the Parkinson disease-associated protein alpha-synuclein. J Biol Chem. 2011 Jun 10; 286(23):20710-26.
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      17. Asensio CS, Sirkis DW, Edwards RH. RNAi screen identifies a role for adaptor protein AP-3 in sorting to the regulated secretory pathway. J Cell Biol. 2010 Dec 13; 191(6):1173-87.
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      18. Scherrer G, Low SA, Wang X, Zhang J, Yamanaka H, Urban R, Solorzano C, Harper B, Hnasko TS, Edwards RH, Basbaum AI. VGLUT2 expression in primary afferent neurons is essential for normal acute pain and injury-induced heat hypersensitivity. Proc Natl Acad Sci U S A. 2010 Dec 21; 107(51):22296-301.
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      19. Juge N, Gray JA, Omote H, Miyaji T, Inoue T, Hara C, Uneyama H, Edwards RH, Nicoll RA, Moriyama Y. Metabolic control of vesicular glutamate transport and release. Neuron. 2010 Oct 6; 68(1):99-112.
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      20. Stuber GD, Hnasko TS, Britt JP, Edwards RH, Bonci A. Dopaminergic terminals in the nucleus accumbens but not the dorsal striatum corelease glutamate. J Neurosci. 2010 Jun 16; 30(24):8229-33.
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      21. Onoa B, Li H, Gagnon-Bartsch JA, Elias LA, Edwards RH. Vesicular monoamine and glutamate transporters select distinct synaptic vesicle recycling pathways. J Neurosci. 2010 Jun 9; 30(23):7917-27.
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      22. Hnasko TS, Chuhma N, Zhang H, Goh GY, Sulzer D, Palmiter RD, Rayport S, Edwards RH. Vesicular glutamate transport promotes dopamine storage and glutamate corelease in vivo. Neuron. 2010 Mar 11; 65(5):643-56.
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      23. Anantharam A, Onoa B, Edwards RH, Holz RW, Axelrod D. Localized topological changes of the plasma membrane upon exocytosis visualized by polarized TIRFM. J Cell Biol. 2010 Feb 8; 188(3):415-28.
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      24. Noh J, Seal RP, Garver JA, Edwards RH, Kandler K. Glutamate co-release at GABA/glycinergic synapses is crucial for the refinement of an inhibitory map. Nat Neurosci. 2010 Feb; 13(2):232-8.
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      25. Nemani VM, Lu W, Berge V, Nakamura K, Onoa B, Lee MK, Chaudhry FA, Nicoll RA, Edwards RH. Increased expression of alpha-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis. Neuron. 2010 Jan 14; 65(1):66-79.
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      26. Fortin DL, Nemani VM, Nakamura K, Edwards RH. The behavior of alpha-synuclein in neurons. Mov Disord. 2010; 25 Suppl 1:S21-6.
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      27. Seal RP, Wang X, Guan Y, Raja SN, Woodbury CJ, Basbaum AI, Edwards RH. Injury-induced mechanical hypersensitivity requires C-low threshold mechanoreceptors. Nature. 2009 Dec 3; 462(7273):651-5.
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      28. Hur EE, Edwards RH, Rommer E, Zaborszky L. Vesicular glutamate transporter 1 and vesicular glutamate transporter 2 synapses on cholinergic neurons in the sublenticular gray of the rat basal forebrain: a double-label electron microscopic study. Neuroscience. 2009 Dec 29; 164(4):1721-31.
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      29. Zhang H, Gubernator NG, Yue M, Staal RG, Mosharov EV, Pereira D, Balsanek V, Vadola PA, Mukherjee B, Edwards RH, Sulzer D, Sames D. Dopamine release at individual presynaptic terminals visualized with FFNs. J Vis Exp. 2009; (30).
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      30. Gubernator NG, Zhang H, Staal RG, Mosharov EV, Pereira DB, Yue M, Balsanek V, Vadola PA, Mukherjee B, Edwards RH, Sulzer D, Sames D. Fluorescent false neurotransmitters visualize dopamine release from individual presynaptic terminals. Science. 2009 Jun 12; 324(5933):1441-4.
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      31. Mosharov EV, Larsen KE, Kanter E, Phillips KA, Wilson K, Schmitz Y, Krantz DE, Kobayashi K, Edwards RH, Sulzer D. Interplay between cytosolic dopamine, calcium, and alpha-synuclein causes selective death of substantia nigra neurons. Neuron. 2009 Apr 30; 62(2):218-29.
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      32. Blankenship AG, Ford KJ, Johnson J, Seal RP, Edwards RH, Copenhagen DR, Feller MB. Synaptic and extrasynaptic factors governing glutamatergic retinal waves. Neuron. 2009 Apr 30; 62(2):230-41.
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      33. Edwards R. What the neuron tells glia. Neuron. 2009 Mar 26; 61(6):811-2.
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      34. Nakamura K, Nemani VM, Wallender EK, Kaehlcke K, Ott M, Edwards RH. Optical reporters for the conformation of alpha-synuclein reveal a specific interaction with mitochondria. J Neurosci. 2008 Nov 19; 28(47):12305-17.
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      35. Marchaland J, Calì C, Voglmaier SM, Li H, Regazzi R, Edwards RH, Bezzi P. Fast subplasma membrane Ca2+ transients control exo-endocytosis of synaptic-like microvesicles in astrocytes. J Neurosci. 2008 Sep 10; 28(37):9122-32.
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      36. Riedel A, Westerholz S, Braun K, Edwards RH, Arendt T, Härtig W. Vesicular glutamate transporter 3-immunoreactive pericellular baskets ensheath a distinct population of neurons in the lateral septum. J Chem Neuroanat. 2008 Dec; 36(3-4):177-90.
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      37. Boulland JL, Jenstad M, Boekel AJ, Wouterlood FG, Edwards RH, Storm-Mathisen J, Chaudhry FA. Vesicular glutamate and GABA transporters sort to distinct sets of vesicles in a population of presynaptic terminals. Cereb Cortex. 2009 Jan; 19(1):241-8.
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      38. Adam Y, Edwards RH, Schuldiner S. Expression and function of the rat vesicular monoamine transporter 2. Am J Physiol Cell Physiol. 2008 Apr; 294(4):C1004-11.
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      39. Seal RP, Akil O, Yi E, Weber CM, Grant L, Yoo J, Clause A, Kandler K, Noebels JL, Glowatzki E, Lustig LR, Edwards RH. Sensorineural deafness and seizures in mice lacking vesicular glutamate transporter 3. Neuron. 2008 Jan 24; 57(2):263-75.
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      40. Chaudhry FA, Edwards RH, Fonnum F. Vesicular neurotransmitter transporters as targets for endogenous and exogenous toxic substances. Annu Rev Pharmacol Toxicol. 2008; 48:277-301.
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      41. Chaudhry FA, Boulland JL, Jenstad M, Bredahl MK, Edwards RH. Pharmacology of neurotransmitter transport into secretory vesicles. Handb Exp Pharmacol. 2008; (184):77-106.
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      42. Edwards RH. The neurotransmitter cycle and quantal size. Neuron. 2007 Sep 20; 55(6):835-58.
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      43. Nakamura K, Edwards RH. Physiology versus pathology in Parkinson's disease. Proc Natl Acad Sci U S A. 2007 Jul 17; 104(29):11867-8.
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      44. Johnson J, Fremeau RT, Duncan JL, Rentería RC, Yang H, Hua Z, Liu X, LaVail MM, Edwards RH, Copenhagen DR. Vesicular glutamate transporter 1 is required for photoreceptor synaptic signaling but not for intrinsic visual functions. J Neurosci. 2007 Jul 4; 27(27):7245-55.
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      45. Snead AN, Santos MS, Seal RP, Miyakawa M, Edwards RH, Scanlan TS. Thyronamines inhibit plasma membrane and vesicular monoamine transport. ACS Chem Biol. 2007 Jun 15; 2(6):390-8.
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      46. Voglmaier SM, Edwards RH. Do different endocytic pathways make different synaptic vesicles? Curr Opin Neurobiol. 2007 Jun; 17(3):374-80.
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      47. Larsen KE, Schmitz Y, Troyer MD, Mosharov E, Dietrich P, Quazi AZ, Savalle M, Nemani V, Chaudhry FA, Edwards RH, Stefanis L, Sulzer D. Alpha-synuclein overexpression in PC12 and chromaffin cells impairs catecholamine release by interfering with a late step in exocytosis. J Neurosci. 2006 Nov 15; 26(46):11915-22.
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      48. Hnasko TS, Edwards RH. Synaptic vesicles: half full or half empty? Neuron. 2006 Sep 7; 51(5):523-4.
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      49. Morimoto R, Uehara S, Yatsushiro S, Juge N, Hua Z, Senoh S, Echigo N, Hayashi M, Mizoguchi T, Ninomiya T, Udagawa N, Omote H, Yamamoto A, Edwards RH, Moriyama Y. Secretion of L-glutamate from osteoclasts through transcytosis. EMBO J. 2006 Sep 20; 25(18):4175-86.
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      50. Mosharov EV, Staal RG, Bové J, Prou D, Hananiya A, Markov D, Poulsen N, Larsen KE, Moore CM, Troyer MD, Edwards RH, Przedborski S, Sulzer D. Alpha-synuclein overexpression increases cytosolic catecholamine concentration. J Neurosci. 2006 Sep 6; 26(36):9304-11.
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      51. Persson S, Boulland JL, Aspling M, Larsson M, Fremeau RT, Edwards RH, Storm-Mathisen J, Chaudhry FA, Broman J. Distribution of vesicular glutamate transporters 1 and 2 in the rat spinal cord, with a note on the spinocervical tract. J Comp Neurol. 2006 Aug 10; 497(5):683-701.
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      52. Voglmaier SM, Kam K, Yang H, Fortin DL, Hua Z, Nicoll RA, Edwards RH. Distinct endocytic pathways control the rate and extent of synaptic vesicle protein recycling. Neuron. 2006 Jul 6; 51(1):71-84.
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      53. Badagnani I, Sorani M, Edwards RH, Brown C, Castro RA, Huang CC, Stryke D, Kawamoto M, Johns SJ, Carlson EJ, Taylor T, Chan W, De La Cruz M, Ferrin TE, Burchard EG, Herskowitz I, Kroetz DL, Giacomini KM. PharmGKB submission update: VI. PMT submissions of genetic variations in neurotransmitter transporters (SLC6, SLC17, and SLC18) to the PharmGKB network. Pharmacol Rev. 2006 Mar; 58(1):5-6.
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      54. Glatt C, Almonte M, Taylor T, Edwards RH, Freimer N, Tanner C. Structural variants in the vesicular monoamine transporter do not contribute to sporadic Parkinson's disease. Mov Disord. 2006 Mar; 21(3):426-7.
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      55. Martín-Ibañez R, Jenstad M, Berghuis P, Edwards RH, Hioki H, Kaneko T, Mulder J, Canals JM, Ernfors P, Chaudhry FA, Harkany T. Vesicular glutamate transporter 3 (VGLUT3) identifies spatially segregated excitatory terminals in the rat substantia nigra. Eur J Neurosci. 2006 Feb; 23(4):1063-70.
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      56. Franke H, Grummich B, Härtig W, Grosche J, Regenthal R, Edwards RH, Illes P, Krügel U. Changes in purinergic signaling after cerebral injury -- involvement of glutamatergic mechanisms? Int J Dev Neurosci. 2006 Apr-May; 24(2-3):123-32.
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      57. Seal RP, Edwards RH. The diverse roles of vesicular glutamate transporter 3. Handb Exp Pharmacol. 2006; (175):137-50.
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      58. Seal RP, Edwards RH. Functional implications of neurotransmitter co-release: glutamate and GABA share the load. Curr Opin Pharmacol. 2006 Feb; 6(1):114-9.
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      59. Li H, Waites CL, Staal RG, Dobryy Y, Park J, Sulzer DL, Edwards RH. Sorting of vesicular monoamine transporter 2 to the regulated secretory pathway confers the somatodendritic exocytosis of monoamines. Neuron. 2005 Nov 23; 48(4):619-33.
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      60. Fortin DL, Nemani VM, Voglmaier SM, Anthony MD, Ryan TA, Edwards RH. Neural activity controls the synaptic accumulation of alpha-synuclein. J Neurosci. 2005 Nov 23; 25(47):10913-21.
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      61. Kubo S, Nemani VM, Chalkley RJ, Anthony MD, Hattori N, Mizuno Y, Edwards RH, Fortin DL. A combinatorial code for the interaction of alpha-synuclein with membranes. J Biol Chem. 2005 Sep 9; 280(36):31664-72.
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      62. Sulzer D, Edwards RH. Antidepressants and the monoamine masquerade. Neuron. 2005 Apr 7; 46(1):1-2.
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      63. Boulland JL, Qureshi T, Seal RP, Rafiki A, Gundersen V, Bergersen LH, Fremeau RT, Edwards RH, Storm-Mathisen J, Chaudhry FA. Expression of the vesicular glutamate transporters during development indicates the widespread corelease of multiple neurotransmitters. J Comp Neurol. 2004 Dec 13; 480(3):264-80.
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      64. Croft BG, Fortin GD, Corera AT, Edwards RH, Beaudet A, Trudeau LE, Fon EA. Normal biogenesis and cycling of empty synaptic vesicles in dopamine neurons of vesicular monoamine transporter 2 knockout mice. Mol Biol Cell. 2005 Jan; 16(1):306-15.
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      65. Kao YH, Lassová L, Bar-Yehuda T, Edwards RH, Sterling P, Vardi N. Evidence that certain retinal bipolar cells use both glutamate and GABA. J Comp Neurol. 2004 Oct 18; 478(3):207-18.
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      66. Johnson J, Sherry DM, Liu X, Fremeau RT, Seal RP, Edwards RH, Copenhagen DR. Vesicular glutamate transporter 3 expression identifies glutamatergic amacrine cells in the rodent retina. J Comp Neurol. 2004 Sep 27; 477(4):386-98.
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      67. Burman J, Tran CH, Glatt C, Freimer NB, Edwards RH. The effect of rare human sequence variants on the function of vesicular monoamine transporter 2. Pharmacogenetics. 2004 Sep; 14(9):587-94.
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      68. Fortin DL, Troyer MD, Nakamura K, Kubo S, Anthony MD, Edwards RH. Lipid rafts mediate the synaptic localization of alpha-synuclein. J Neurosci. 2004 Jul 28; 24(30):6715-23.
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      69. Harkany T, Holmgren C, Härtig W, Qureshi T, Chaudhry FA, Storm-Mathisen J, Dobszay MB, Berghuis P, Schulte G, Sousa KM, Fremeau RT, Edwards RH, Mackie K, Ernfors P, Zilberter Y. Endocannabinoid-independent retrograde signaling at inhibitory synapses in layer 2/3 of neocortex: involvement of vesicular glutamate transporter 3. J Neurosci. 2004 May 26; 24(21):4978-88.
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      70. Fremeau RT, Kam K, Qureshi T, Johnson J, Copenhagen DR, Storm-Mathisen J, Chaudhry FA, Nicoll RA, Edwards RH. Vesicular glutamate transporters 1 and 2 target to functionally distinct synaptic release sites. Science. 2004 Jun 18; 304(5678):1815-9.
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      71. Whitley J, Parsons J, Freeman J, Liu Y, Edwards RH, Near JA. Electrochemical monitoring of transport by a vesicular monoamine transporter expressed in Xenopus oocytes. J Neurosci Methods. 2004 Feb 15; 133(1-2):191-9.
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      72. Fremeau RT, Voglmaier S, Seal RP, Edwards RH. VGLUTs define subsets of excitatory neurons and suggest novel roles for glutamate. Trends Neurosci. 2004 Feb; 27(2):98-103.
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      73. Lin LH, Edwards RH, Fremeau RT, Fujiyama F, Kaneko T, Talman WT. Localization of vesicular glutamate transporters and neuronal nitric oxide synthase in rat nucleus tractus solitarii. Neuroscience. 2004; 123(1):247-55.
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      74. Alonso-Nanclares L, Minelli A, Melone M, Edwards RH, Defelipe J, Conti F. Perisomatic glutamatergic axon terminals: a novel feature of cortical synaptology revealed by vesicular glutamate transporter 1 immunostaining. Neuroscience. 2004; 123(2):547-56.
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      75. Oliveira AL, Hydling F, Olsson E, Shi T, Edwards RH, Fujiyama F, Kaneko T, Hökfelt T, Cullheim S, Meister B. Cellular localization of three vesicular glutamate transporter mRNAs and proteins in rat spinal cord and dorsal root ganglia. Synapse. 2003 Nov; 50(2):117-29.
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      76. Härtig W, Riedel A, Grosche J, Edwards RH, Fremeau RT, Harkany T, Brauer K, Arendt T. Complementary distribution of vesicular glutamate transporters 1 and 2 in the nucleus accumbens of rat: Relationship to calretinin-containing extrinsic innervation and calbindin-immunoreactive neurons. J Comp Neurol. 2003 Oct 6; 465(1):1-10.
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      77. Harkany T, Härtig W, Berghuis P, Dobszay MB, Zilberter Y, Edwards RH, Mackie K, Ernfors P. Complementary distribution of type 1 cannabinoid receptors and vesicular glutamate transporter 3 in basal forebrain suggests input-specific retrograde signalling by cholinergic neurons. Eur J Neurosci. 2003 Oct; 18(7):1979-92.
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      78. Collin M, Bäckberg M, Ovesjö ML, Fisone G, Edwards RH, Fujiyama F, Meister B. Plasma membrane and vesicular glutamate transporter mRNAs/proteins in hypothalamic neurons that regulate body weight. Eur J Neurosci. 2003 Sep; 18(5):1265-78.
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      79. Reimer RJ, Edwards RH. Organic anion transport is the primary function of the SLC17/type I phosphate transporter family. Pflugers Arch. 2004 Feb; 447(5):629-35.
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      80. Minelli A, Edwards RH, Manzoni T, Conti F. Postnatal development of the glutamate vesicular transporter VGLUT1 in rat cerebral cortex. Brain Res Dev Brain Res. 2003 Feb 16; 140(2):309-14.
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      81. Wreden CC, Johnson J, Tran C, Seal RP, Copenhagen DR, Reimer RJ, Edwards RH. The H+-coupled electrogenic lysosomal amino acid transporter LYAAT1 localizes to the axon and plasma membrane of hippocampal neurons. J Neurosci. 2003 Feb 15; 23(4):1265-75.
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      82. Johnson J, Tian N, Caywood MS, Reimer RJ, Edwards RH, Copenhagen DR. Vesicular neurotransmitter transporter expression in developing postnatal rodent retina: GABA and glycine precede glutamate. J Neurosci. 2003 Jan 15; 23(2):518-29.
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      83. Sperk G, Schwarzer C, Heilman J, Furtinger S, Reimer RJ, Edwards RH, Nelson N. Expression of plasma membrane GABA transporters but not of the vesicular GABA transporter in dentate granule cells after kainic acid seizures. Hippocampus. 2003; 13(7):806-15.
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      84. Minelli A, Alonso-Nanclares L, Edwards RH, DeFelipe J, Conti F. Postnatal development of the vesicular GABA transporter in rat cerebral cortex. Neuroscience. 2003; 117(2):337-46.
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      85. Fremeau RT, Burman J, Qureshi T, Tran CH, Proctor J, Johnson J, Zhang H, Sulzer D, Copenhagen DR, Storm-Mathisen J, Reimer RJ, Chaudhry FA, Edwards RH. The identification of vesicular glutamate transporter 3 suggests novel modes of signaling by glutamate. Proc Natl Acad Sci U S A. 2002 Oct 29; 99(22):14488-93.
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      86. Larsen KE, Fon EA, Hastings TG, Edwards RH, Sulzer D. Methamphetamine-induced degeneration of dopaminergic neurons involves autophagy and upregulation of dopamine synthesis. J Neurosci. 2002 Oct 15; 22(20):8951-60.
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      87. Boulland JL, Osen KK, Levy LM, Danbolt NC, Edwards RH, Storm-Mathisen J, Chaudhry FA. Cell-specific expression of the glutamine transporter SN1 suggests differences in dependence on the glutamine cycle. Eur J Neurosci. 2002 May; 15(10):1615-31.
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      88. Chaudhry FA, Reimer RJ, Edwards RH. The glutamine commute: take the N line and transfer to the A. J Cell Biol. 2002 Apr 29; 157(3):349-55.
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      89. Bröer A, Albers A, Setiawan I, Edwards RH, Chaudhry FA, Lang F, Wagner CA, Bröer S. Regulation of the glutamine transporter SN1 by extracellular pH and intracellular sodium ions. J Physiol. 2002 Feb 15; 539(Pt 1):3-14.
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      90. Chaudhry FA, Schmitz D, Reimer RJ, Larsson P, Gray AT, Nicoll R, Kavanaugh M, Edwards RH. Glutamine uptake by neurons: interaction of protons with system a transporters. J Neurosci. 2002 Jan 1; 22(1):62-72.
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      91. Chaudhry FA, Krizaj D, Larsson P, Reimer RJ, Wreden C, Storm-Mathisen J, Copenhagen D, Kavanaugh M, Edwards RH. Coupled and uncoupled proton movement by amino acid transport system N. EMBO J. 2001 Dec 17; 20(24):7041-51.
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      92. Fremeau RT, Troyer MD, Pahner I, Nygaard GO, Tran CH, Reimer RJ, Bellocchio EE, Fortin D, Storm-Mathisen J, Edwards RH. The expression of vesicular glutamate transporters defines two classes of excitatory synapse. Neuron. 2001 Aug 2; 31(2):247-60.
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      93. Reimer RJ, Fremeau RT, Bellocchio EE, Edwards RH. The essence of excitation. Curr Opin Cell Biol. 2001 Aug; 13(4):417-21.
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      94. Fon EA, Edwards RH. Molecular mechanisms of neurotransmitter release. Muscle Nerve. 2001 May; 24(5):581-601.
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      95. Glatt CE, DeYoung JA, Delgado S, Service SK, Giacomini KM, Edwards RH, Risch N, Freimer NB. Screening a large reference sample to identify very low frequency sequence variants: comparisons between two genes. Nat Genet. 2001 Apr; 27(4):435-8.
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      96. Waites CL, Mehta A, Tan PK, Thomas G, Edwards RH, Krantz DE. An acidic motif retains vesicular monoamine transporter 2 on large dense core vesicles. J Cell Biol. 2001 Mar 19; 152(6):1159-68.
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      97. Edwards RH. Drug delivery via the blood-brain barrier. Nat Neurosci. 2001 Mar; 4(3):221-2.
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      98. Minelli A, Barbaresi P, Reimer RJ, Edwards RH, Conti F. The glial glutamate transporter GLT-1 is localized both in the vicinity of and at distance from axon terminals in the rat cerebral cortex. Neuroscience. 2001; 108(1):51-9.
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      99. Sulzer D, Bogulavsky J, Larsen KE, Behr G, Karatekin E, Kleinman MH, Turro N, Krantz D, Edwards RH, Greene LA, Zecca L. Neuromelanin biosynthesis is driven by excess cytosolic catecholamines not accumulated by synaptic vesicles. Proc Natl Acad Sci U S A. 2000 Oct 24; 97(22):11869-74.
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      100. Sulzer D, Edwards R. Vesicles: equal in neurotransmitter concentration but not in volume. Neuron. 2000 Oct; 28(1):5-7.
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      101. Pothos EN, Larsen KE, Krantz DE, Liu Y, Haycock JW, Setlik W, Gershon MD, Edwards RH, Sulzer D. Synaptic vesicle transporter expression regulates vesicle phenotype and quantal size. J Neurosci. 2000 Oct 1; 20(19):7297-306.
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      102. Bellocchio EE, Reimer RJ, Fremeau RT, Edwards RH. Uptake of glutamate into synaptic vesicles by an inorganic phosphate transporter. Science. 2000 Aug 11; 289(5481):957-60.
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      103. Reimer RJ, Chaudhry FA, Gray AT, Edwards RH. Amino acid transport system A resembles system N in sequence but differs in mechanism. Proc Natl Acad Sci U S A. 2000 Jul 5; 97(14):7715-20.
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      104. Krantz DE, Waites C, Oorschot V, Liu Y, Wilson RI, Tan PK, Klumperman J, Edwards RH. A phosphorylation site regulates sorting of the vesicular acetylcholine transporter to dense core vesicles. J Cell Biol. 2000 Apr 17; 149(2):379-96.
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      105. Chaudhry FA, Reimer RJ, Krizaj D, Barber D, Storm-Mathisen J, Copenhagen DR, Edwards RH. Molecular analysis of system N suggests novel physiological roles in nitrogen metabolism and synaptic transmission. Cell. 1999 Dec 23; 99(7):769-80.
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      106. Liu Y, Krantz DE, Waites C, Edwards RH. Membrane trafficking of neurotransmitter transporters in the regulation of synaptic transmission. Trends Cell Biol. 1999 Sep; 9(9):356-63.
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      107. Edwards RH. Neurotransmitter release: variations on a theme. Curr Biol. 1998 Dec 3; 8(24):R883-5.
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      108. Chaudhry FA, Reimer RJ, Bellocchio EE, Danbolt NC, Osen KK, Edwards RH, Storm-Mathisen J. The vesicular GABA transporter, VGAT, localizes to synaptic vesicles in sets of glycinergic as well as GABAergic neurons. J Neurosci. 1998 Dec 1; 18(23):9733-50.
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      109. Lebrand C, Cases O, Wehrlé R, Blakely RD, Edwards RH, Gaspar P. Transient developmental expression of monoamine transporters in the rodent forebrain. J Comp Neurol. 1998 Nov 30; 401(4):506-24.
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      110. Bellocchio EE, Hu H, Pohorille A, Chan J, Pickel VM, Edwards RH. The localization of the brain-specific inorganic phosphate transporter suggests a specific presynaptic role in glutamatergic transmission. J Neurosci. 1998 Nov 1; 18(21):8648-59.
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      111. Kulwichit W, Edwards RH, Davenport EM, Baskar JF, Godfrey V, Raab-Traub N. Expression of the Epstein-Barr virus latent membrane protein 1 induces B cell lymphoma in transgenic mice. Proc Natl Acad Sci U S A. 1998 Sep 29; 95(20):11963-8.
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      112. Tan PK, Waites C, Liu Y, Krantz DE, Edwards RH. A leucine-based motif mediates the endocytosis of vesicular monoamine and acetylcholine transporters. J Biol Chem. 1998 Jul 10; 273(28):17351-60.
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      113. Speciale SG, Liang CL, Sonsalla PK, Edwards RH, German DC. The neurotoxin 1-methyl-4-phenylpyridinium is sequestered within neurons that contain the vesicular monoamine transporter. Neuroscience. 1998 Jun; 84(4):1177-85.
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      114. Reimer RJ, Fon EA, Edwards RH. Vesicular neurotransmitter transport and the presynaptic regulation of quantal size. Curr Opin Neurobiol. 1998 Jun; 8(3):405-12.
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      115. Sievert MK, Thiriot DS, Edwards RH, Ruoho AE. High-efficiency expression and characterization of the synaptic-vesicle monoamine transporter from baculovirus-infected insect cells. Biochem J. 1998 Mar 1; 330 ( Pt 2):959-66.
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      116. Finn JP, Edwards RH. Multiple residues contribute independently to differences in ligand recognition between vesicular monoamine transporters 1 and 2. J Biol Chem. 1998 Feb 13; 273(7):3943-7.
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      117. Roghani A, Shirzadi A, Butcher LL, Edwards RH. Distribution of the vesicular transporter for acetylcholine in the rat central nervous system. Neuroscience. 1998 Feb; 82(4):1195-212.
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      118. Finn JP, Merickel A, Peter D, Edwards RH. Ligand recognition by the vesicular monoamine transporters. Adv Pharmacol. 1998; 42:232-6.
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      119. Nirenberg MJ, Chan J, Liu Y, Edwards RH, Pickel VM. Ultrastructural localization of the vesicular monoamine transporter 2 in mesolimbic and nigrostriatal dopaminergic neurons. Adv Pharmacol. 1998; 42:240-3.
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      120. Finn JP, Merickel A, Edwards RH. Analysis of neurotransmitter transport into secretory vesicles. Methods Enzymol. 1998; 296:144-62.
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      121. Fon EA, Pothos EN, Sun BC, Killeen N, Sulzer D, Edwards RH. Vesicular transport regulates monoamine storage and release but is not essential for amphetamine action. Neuron. 1997 Dec; 19(6):1271-83.
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      122. Liu Y, Edwards RH. Differential localization of vesicular acetylcholine and monoamine transporters in PC12 cells but not CHO cells. J Cell Biol. 1997 Nov 17; 139(4):907-16.
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      123. Hersch SM, Yi H, Heilman CJ, Edwards RH, Levey AI. Subcellular localization and molecular topology of the dopamine transporter in the striatum and substantia nigra. J Comp Neurol. 1997 Nov 17; 388(2):211-27.
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      124. McIntire SL, Reimer RJ, Schuske K, Edwards RH, Jorgensen EM. Identification and characterization of the vesicular GABA transporter. Nature. 1997 Oct 23; 389(6653):870-6.
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      125. Finn JP, Edwards RH. Individual residues contribute to multiple differences in ligand recognition between vesicular monoamine transporters 1 and 2. J Biol Chem. 1997 Jun 27; 272(26):16301-7.
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      126. Nirenberg MJ, Chan J, Liu Y, Edwards RH, Pickel VM. Vesicular monoamine transporter-2: immunogold localization in striatal axons and terminals. Synapse. 1997 Jun; 26(2):194-8.
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      127. Song H, Ming G, Fon E, Bellocchio E, Edwards RH, Poo M. Expression of a putative vesicular acetylcholine transporter facilitates quantal transmitter packaging. Neuron. 1997 May; 18(5):815-26.
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      128. Krantz DE, Peter D, Liu Y, Edwards RH. Phosphorylation of a vesicular monoamine transporter by casein kinase II. J Biol Chem. 1997 Mar 7; 272(10):6752-9.
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      129. Merickel A, Kaback HR, Edwards RH. Charged residues in transmembrane domains II and XI of a vesicular monoamine transporter form a charge pair that promotes high affinity substrate recognition. J Biol Chem. 1997 Feb 28; 272(9):5403-8.
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      130. Liu Y, Edwards RH. The role of vesicular transport proteins in synaptic transmission and neural degeneration. Annu Rev Neurosci. 1997; 20:125-56.
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      131. Grodsky GM, Ma YH, Edwards RH. Chronic sympathetic innervation of islets in transgenic mice results in differential desensitization of alpha-adrenergic inhibition of insulin secretion. Adv Exp Med Biol. 1997; 426:129-38.
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      132. Roghani A, Shirzadi A, Kohan SA, Edwards RH, Butcher LL. Differential distribution of the putative vesicular transporter for acetylcholine in the rat central nervous system. Brain Res Mol Brain Res. 1996 Dec 31; 43(1-2):65-76.
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      133. De Giorgio R, Su D, Peter D, Edwards RH, Brecha NC, Sternini C. Vesicular monoamine transporter 2 expression in enteric neurons and enterochromaffin-like cells of the rat. Neurosci Lett. 1996 Oct 18; 217(2-3):77-80.
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      134. Nirenberg MJ, Chan J, Liu Y, Edwards RH, Pickel VM. Ultrastructural localization of the vesicular monoamine transporter-2 in midbrain dopaminergic neurons: potential sites for somatodendritic storage and release of dopamine. J Neurosci. 1996 Jul 1; 16(13):4135-45.
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      135. Roghani A, Welch C, Xia Y, Liu Y, Peter D, Finn JP, Edwards RH, Lusis AJ. Assignment of the mouse vesicular monoamine transporter genes, Slc18a1 and Slc18a2, to chromosomes 8 and 19 by linkage analysis. Mamm Genome. 1996 May; 7(5):393-4.
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      136. Gilmor ML, Nash NR, Roghani A, Edwards RH, Yi H, Hersch SM, Levey AI. Expression of the putative vesicular acetylcholine transporter in rat brain and localization in cholinergic synaptic vesicles. J Neurosci. 1996 Apr 1; 16(7):2179-90.
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      137. Naudon L, Raisman-Vozari R, Edwards RH, Leroux-Nicollet I, Peter D, Liu Y, Costentin J. Reserpine affects differentially the density of the vesicular monoamine transporter and dihydrotetrabenazine binding sites. Eur J Neurosci. 1996 Apr; 8(4):842-6.
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      138. Peter D, Vu T, Edwards RH. Chimeric vesicular monoamine transporters identify structural domains that influence substrate affinity and sensitivity to tetrabenazine. J Biol Chem. 1996 Feb 9; 271(6):2979-86.
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      139. Peter D, Jimenez J, Liu Y, Merickel A, Krantz D, Edwards RH. Drug interactions with vesicular amine transport. NIDA Res Monogr. 1996; 161:176-200.
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      140. Liu Y, Peter D, Merickel A, Krantz D, Finn JP, Edwards RH. A molecular analysis of vesicular amine transport. Behav Brain Res. 1996; 73(1-2):51-8.
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      141. Liu Y, Waites C, Krantz D, Tan P, Edwards RH. Molecular analysis of neurotransmitter transport into secretory vesicles. Cold Spring Harb Symp Quant Biol. 1996; 61:747-58.
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      142. Merickel A, Edwards RH. Transport of histamine by vesicular monoamine transporter-2. Neuropharmacology. 1995 Nov; 34(11):1543-7.
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      143. Merickel A, Rosandich P, Peter D, Edwards RH. Identification of residues involved in substrate recognition by a vesicular monoamine transporter. J Biol Chem. 1995 Oct 27; 270(43):25798-804.
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      144. Nirenberg MJ, Liu Y, Peter D, Edwards RH, Pickel VM. The vesicular monoamine transporter 2 is present in small synaptic vesicles and preferentially localizes to large dense core vesicles in rat solitary tract nuclei. Proc Natl Acad Sci U S A. 1995 Sep 12; 92(19):8773-7.
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      145. Peter D, Liu Y, Sternini C, de Giorgio R, Brecha N, Edwards RH. Differential expression of two vesicular monoamine transporters. J Neurosci. 1995 Sep; 15(9):6179-88.
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      146. Peter D, Liu Y, Brecha N, Edwards RH. The transport of neurotransmitters into synaptic vesicles. Prog Brain Res. 1995; 105:273-81.
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      147. Liu Y, Schweitzer ES, Nirenberg MJ, Pickel VM, Evans CJ, Edwards RH. Preferential localization of a vesicular monoamine transporter to dense core vesicles in PC12 cells. J Cell Biol. 1994 Dec; 127(5):1419-33.
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      148. Roghani A, Feldman J, Kohan SA, Shirzadi A, Gundersen CB, Brecha N, Edwards RH. Molecular cloning of a putative vesicular transporter for acetylcholine. Proc Natl Acad Sci U S A. 1994 Oct 25; 91(22):10620-4.
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      149. Peter D, Jimenez J, Liu Y, Kim J, Edwards RH. The chromaffin granule and synaptic vesicle amine transporters differ in substrate recognition and sensitivity to inhibitors. J Biol Chem. 1994 Mar 11; 269(10):7231-7.
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      150. Miller DG, Edwards RH, Miller AD. Cloning of the cellular receptor for amphotropic murine retroviruses reveals homology to that for gibbon ape leukemia virus. Proc Natl Acad Sci U S A. 1994 Jan 4; 91(1):78-82.
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      151. Peter D, Finn JP, Klisak I, Liu Y, Kojis T, Heinzmann C, Roghani A, Sparkes RS, Edwards RH. Chromosomal localization of the human vesicular amine transporter genes. Genomics. 1993 Dec; 18(3):720-3.
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      152. Edwards RH. Neural degeneration and the transport of neurotransmitters. Ann Neurol. 1993 Nov; 34(5):638-45.
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      153. Schuldiner S, Liu Y, Edwards RH. Reserpine binding to a vesicular amine transporter expressed in Chinese hamster ovary fibroblasts. J Biol Chem. 1993 Jan 5; 268(1):29-34.
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      154. Butcher LL, Oh JD, Woolf NJ, Edwards RH, Roghani A. Organization of central cholinergic neurons revealed by combined in situ hybridization histochemistry and choline-O-acetyltransferase immunocytochemistry. Neurochem Int. 1992 Oct; 21(3):429-45.
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      155. Edwards RH. The transport of neurotransmitters into synaptic vesicles. Curr Opin Neurobiol. 1992 Oct; 2(5):586-94.
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      156. Feany MB, Lee S, Edwards RH, Buckley KM. The synaptic vesicle protein SV2 is a novel type of transmembrane transporter. Cell. 1992 Sep 4; 70(5):861-7.
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      157. Liu Y, Peter D, Roghani A, Schuldiner S, Privé GG, Eisenberg D, Brecha N, Edwards RH. A cDNA that suppresses MPP+ toxicity encodes a vesicular amine transporter. Cell. 1992 Aug 21; 70(4):539-51.
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      158. West-Jordan JA, Martin PA, Abraham RJ, Edwards RH, Jackson MJ. Energy metabolism during damaging contractile activity in isolated skeletal muscle: a 31P-NMR study. Clin Chim Acta. 1991 Dec 16; 203(2-3):119-34.
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      159. Sagar SM, Edwards RH, Sharp FR. Epidermal growth factor and transforming growth factor alpha induce c-fos gene expression in retinal Muller cells in vivo. J Neurosci Res. 1991 Aug; 29(4):549-59.
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      160. MacLennan PA, McArdle A, Edwards RH. Acute effects of phorbol esters on the protein-synthetic rate and carbohydrate metabolism of normal and mdx mouse muscles. Biochem J. 1991 Apr 15; 275 ( Pt 2):477-83.
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      161. Ferriero DM, Head VA, Edwards RH, Sagar SM. Somatostatin mRNA and molecular forms during development of the rat retina. Brain Res Dev Brain Res. 1990 Dec 1; 57(1):15-9.
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      162. Mobley WC, Woo JE, Edwards RH, Riopelle RJ, Longo FM, Weskamp G, Otten U, Valletta JS, Johnston MV. Developmental regulation of nerve growth factor and its receptor in the rat caudate-putamen. Neuron. 1989 Nov; 3(5):655-64.
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      163. Edwards RH, Rutter WJ, Hanahan D. Directed expression of NGF to pancreatic beta cells in transgenic mice leads to selective hyperinnervation of the islets. Cell. 1989 Jul 14; 58(1):161-70.
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      164. Wu BY, Fodor EJ, Edwards RH, Rutter WJ. Nerve growth factor induces the proto-oncogene c-jun in PC12 cells. J Biol Chem. 1989 May 25; 264(15):9000-3.
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      165. Edwards RH, Rutter WJ. Use of vaccinia virus vectors to study protein processing in human disease. Normal nerve growth factor processing and secretion in cultured fibroblasts from patients with familial dysautonomia. J Clin Invest. 1988 Jul; 82(1):44-7.
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      166. Edwards RH, Selby MJ, Mobley WC, Weinrich SL, Hruby DE, Rutter WJ. Processing and secretion of nerve growth factor: expression in mammalian cells with a vaccinia virus vector. Mol Cell Biol. 1988 Jun; 8(6):2456-64.
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      167. Edwards RH, Selby MJ, Garcia PD, Rutter WJ. Processing of the native nerve growth factor precursor to form biologically active nerve growth factor. J Biol Chem. 1988 May 15; 263(14):6810-5.
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      168. Selby MJ, Edwards R, Sharp F, Rutter WJ. Mouse nerve growth factor gene: structure and expression. Mol Cell Biol. 1987 Sep; 7(9):3057-64.
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      169. Selby MJ, Edwards RH, Rutter WJ. Cobra nerve growth factor: structure and evolutionary comparison. J Neurosci Res. 1987; 18(2):293-8.
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      170. Edwards RH, Selby MJ, Rutter WJ. Differential RNA splicing predicts two distinct nerve growth factor precursors. Nature. 1986 Feb 27-Mar 5; 319(6056):784-7.
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      171. Wilkie DR, Dawson MJ, Edwards RH, Gordon RE, Shaw D. 31P NMR studies of resting muscle in normal human subjects. Adv Exp Med Biol. 1984; 170:333-47.
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