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Vikaas Sohal, MD, PhD

TitleAssociate Professor
SchoolUCSF School of Medicine
DepartmentPsychiatry
Address675 Nelson Rising Lane
San Francisco CA 94158
Phone415-502-7377
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    Collapse Research 
    Collapse Research Activities and Funding
    Restoring cognition by optogenetically rescuing gamma rhythms in PFC interneurons
    NIH/NIMH R01MH106507Mar 1, 2015 - Feb 28, 2020
    Role: Principal Investigator
    Identification of enhancers whose activity defines cortical interneuron types
    NIH/NIMH U01MH105948Sep 26, 2014 - Jun 30, 2017
    Role: Co-Principal Investigator
    Cellular and synaptic mechanisms for dopaminergic modulation of prefrontal cortex
    NIH/NIMH R01MH100292Jul 5, 2013 - May 31, 2018
    Role: Principal Investigator
    Reverse engineering the prefrontal microcircuit
    NIH/NIMH DP2MH100011Sep 30, 2012 - Aug 31, 2017
    Role: Principal Investigator
    Optogenetic Tools to Measure Information Processing in Prefrontal Microcircuits
    NIH/NIMH R00MH085946Jul 6, 2009 - May 31, 2013
    Role: Principal Investigator
    Optogenetic Tools to Measure Information Processing in Prefrontal Microcircuits
    NIH/NIMH K99MH085946Jul 6, 2009 - May 31, 2010
    Role: Principal Investigator

    Collapse ORNG Applications 
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    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Robinson SE, Sohal VS. Dopamine D2 receptors modulate pyramidal neurons in mouse medial prefrontal cortex through a stimulatory G protein pathway. J Neurosci. 2017 Sep 14. PMID: 28912160.
      View in: PubMed
    2. Wu PR, Cho KK, Vogt D, Sohal V, Rubenstein JL. The Cytokine CXCL12 Promotes Basket Interneuron Inhibitory Synapses in the Medial Prefrontal Cortex. Cereb Cortex. 2017 Sep 01; 27(9):4303-4313. PMID: 27497284.
      View in: PubMed
    3. Ellwood IT, Patel T, Wadia V, Lee AT, Liptak AT, Bender KJ, Sohal VS. Tonic or Phasic Stimulation of Dopaminergic Projections to Prefrontal Cortex Causes Mice to Maintain or Deviate from Previously Learned Behavioral Strategies. J Neurosci. 2017 Aug 30; 37(35):8315-8329. PMID: 28739583.
      View in: PubMed
    4. Clarkson RL, Liptak AT, Gee SM, Sohal VS, Bender KJ. D3 Receptors Regulate Excitability in a Unique Class of Prefrontal Pyramidal Cells. J Neurosci. 2017 Jun 14; 37(24):5846-5860. PMID: 28522735.
      View in: PubMed
    5. Nahum M, Van Vleet TM, Sohal VS, Mirzabekov JJ, Rao VR, Wallace DL, Lee MB, Dawes H, Stark-Inbar A, Jordan JT, Biagianti B, Merzenich M, Chang EF. Immediate Mood Scaler: Tracking Symptoms of Depression and Anxiety Using a Novel Mobile Mood Scale. JMIR Mhealth Uhealth. 2017 Apr 12; 5(4):e44. PMID: 28404542.
      View in: PubMed
    6. Khoshkhoo S, Vogt D, Sohal VS. Dynamic, Cell-Type-Specific Roles for GABAergic Interneurons in a Mouse Model of Optogenetically Inducible Seizures. Neuron. 2017 Jan 18; 93(2):291-298. PMID: 28041880.
      View in: PubMed
    7. Kjaerby C, Athilingam J, Robinson SE, Iafrati J, Sohal VS. Serotonin 1B Receptors Regulate Prefrontal Function by Gating Callosal and Hippocampal Inputs. Cell Rep. 2016 Dec 13; 17(11):2882-2890. PMID: 27974203.
      View in: PubMed
    8. Lee AT, Sohal VS. Making the Right Connections. Biol Psychiatry. 2016 Oct 01; 80(7):502-3. PMID: 27601338.
      View in: PubMed
    9. Levy ES, Tajon CA, Bischof TS, Iafrati J, Fernandez-Bravo A, Garfield DJ, Chamanzar M, Maharbiz MM, Sohal VS, Schuck PJ, Cohen BE, Chan EM. Energy-Looping Nanoparticles: Harnessing Excited-State Absorption for Deep-Tissue Imaging. ACS Nano. 2016 Sep 27; 10(9):8423-33. PMID: 27603228.
      View in: PubMed
    10. Kirkby LA, Sohal VS. Stressing out the Social Network. Neuron. 2016 Jul 20; 91(2):210-3. PMID: 27477012.
      View in: PubMed
    11. Luongo FJ, Zimmerman CA, Horn ME, Sohal VS. Correlations between prefrontal neurons form a small-world network that optimizes the generation of multineuron sequences of activity. J Neurophysiol. 2016 May 01; 115(5):2359-75. PMID: 26888108.
      View in: PubMed
    12. Luo X, Gee S, Sohal V, Small D. A point-process response model for spike trains from single neurons in neural circuits under optogenetic stimulation. Stat Med. 2016 Feb 10; 35(3):455-74. PMID: 26411923; PMCID: PMC4713323 [Available on 02/10/17].
    13. Mathalon DH, Sohal VS. Neural Oscillations and Synchrony in Brain Dysfunction and Neuropsychiatric Disorders: It's About Time. JAMA Psychiatry. 2015 Aug; 72(8):840-4. PMID: 26039190.
      View in: PubMed
    14. Chamanzar M, Garfield DJ, Iafrati J, Sohal V, Chan E, Cohen B, Schuck PJ, Maharbiz MM. Deep tissue targeted near-infrared optogenetic stimulation using fully implantable upconverting light bulbs. Conf Proc IEEE Eng Med Biol Soc. 2015 Aug; 2015:821-4. PMID: 26736388.
      View in: PubMed
    15. Vogt D, Cho KK, Lee AT, Sohal VS, Rubenstein JL. The parvalbumin/somatostatin ratio is increased in Pten mutant mice and by human PTEN ASD alleles. Cell Rep. 2015 May 12; 11(6):944-956. PMID: 25937288; PMCID: PMC4431948.
    16. Luongo FJ, Horn ME, Sohal VS. Putative Microcircuit-Level Substrates for Attention Are Disrupted in Mouse Models of Autism. Biol Psychiatry. 2016 Apr 15; 79(8):667-75. PMID: 26022075; PMCID: PMC4624609 [Available on 04/15/17].
    17. Marton TF, Sohal VS. Of Mice, Men, and Microbial Opsins: How Optogenetics Can Help Hone Mouse Models of Mental Illness. Biol Psychiatry. 2016 Jan 01; 79(1):47-52. PMID: 25981174; PMCID: PMC4618781 [Available on 01/01/17].
    18. Cho KK, Hoch R, Lee AT, Patel T, Rubenstein JL, Sohal VS. Gamma rhythms link prefrontal interneuron dysfunction with cognitive inflexibility in Dlx5/6(+/-) mice. Neuron. 2015 Mar 18; 85(6):1332-43. PMID: 25754826; PMCID: PMC4503262.
    19. Sohal VS. Identifying pathways leading to prefrontal GABA-ergic interneuron dysfunction in schizophrenia. Am J Psychiatry. 2014 Sep; 171(9):906-9. PMID: 25178745.
      View in: PubMed
    20. Lee AT, Vogt D, Rubenstein JL, Sohal VS. A class of GABAergic neurons in the prefrontal cortex sends long-range projections to the nucleus accumbens and elicits acute avoidance behavior. J Neurosci. 2014 Aug 27; 34(35):11519-25. PMID: 25164650; PMCID: PMC4145166.
    21. Cho KK, Sohal VS. Optogenetic approaches for investigating neural pathways implicated in schizophrenia and related disorders. Hum Mol Genet. 2014 Sep 15; 23(R1):R64-8. PMID: 24824218.
      View in: PubMed
    22. Lee AT, Gee SM, Vogt D, Patel T, Rubenstein JL, Sohal VS. Pyramidal neurons in prefrontal cortex receive subtype-specific forms of excitation and inhibition. Neuron. 2014 Jan 08; 81(1):61-8. PMID: 24361076; PMCID: PMC3947199.
    23. Seybold BA, Stanco A, Cho KK, Potter GB, Kim C, Sohal VS, Rubenstein JL, Schreiner CE. Chronic reduction in inhibition reduces receptive field size in mouse auditory cortex. Proc Natl Acad Sci U S A. 2012 Aug 21; 109(34):13829-34. PMID: 22753490; PMCID: PMC3427089.
    24. Gee S, Ellwood I, Patel T, Luongo F, Deisseroth K, Sohal VS. Synaptic activity unmasks dopamine D2 receptor modulation of a specific class of layer V pyramidal neurons in prefrontal cortex. J Neurosci. 2012 Apr 04; 32(14):4959-71. PMID: 22492051; PMCID: PMC3352768.
    25. Sohal VS. Insights into cortical oscillations arising from optogenetic studies. Biol Psychiatry. 2012 Jun 15; 71(12):1039-45. PMID: 22381731; PMCID: PMC3361599.
    26. Sohal VS, Sun FT. Responsive neurostimulation suppresses synchronized cortical rhythms in patients with epilepsy. Neurosurg Clin N Am. 2011 Oct; 22(4):481-8, vi. PMID: 21939847.
      View in: PubMed
    27. Yizhar O, Fenno LE, Prigge M, Schneider F, Davidson TJ, O'Shea DJ, Sohal VS, Goshen I, Finkelstein J, Paz JT, Stehfest K, Fudim R, Ramakrishnan C, Huguenard JR, Hegemann P, Deisseroth K. Neocortical excitation/inhibition balance in information processing and social dysfunction. Nature. 2011 Jul 27; 477(7363):171-8. PMID: 21796121; PMCID: PMC4155501.
    28. Wang Y, Dye CA, Sohal V, Long JE, Estrada RC, Roztocil T, Lufkin T, Deisseroth K, Baraban SC, Rubenstein JL. Dlx5 and Dlx6 regulate the development of parvalbumin-expressing cortical interneurons. J Neurosci. 2010 Apr 14; 30(15):5334-45. PMID: 20392955; PMCID: PMC2919857.
    29. Gunaydin LA, Yizhar O, Berndt A, Sohal VS, Deisseroth K, Hegemann P. Ultrafast optogenetic control. Nat Neurosci. 2010 Mar; 13(3):387-92. PMID: 20081849.
      View in: PubMed
    30. Sohal VS, Zhang F, Yizhar O, Deisseroth K. Parvalbumin neurons and gamma rhythms enhance cortical circuit performance. Nature. 2009 Jun 04; 459(7247):698-702. PMID: 19396159; PMCID: PMC3969859.
    31. Sohal VS, Pangratz-Fuehrer S, Rudolph U, Huguenard JR. Intrinsic and synaptic dynamics interact to generate emergent patterns of rhythmic bursting in thalamocortical neurons. J Neurosci. 2006 Apr 19; 26(16):4247-55. PMID: 16624945.
      View in: PubMed
    32. Sohal VS, Huguenard JR. Inhibitory coupling specifically generates emergent gamma oscillations in diverse cell types. Proc Natl Acad Sci U S A. 2005 Dec 20; 102(51):18638-43. PMID: 16339306; PMCID: PMC1317969.
    33. Sohal VS, Huguenard JR. Inhibitory interconnections control burst pattern and emergent network synchrony in reticular thalamus. J Neurosci. 2003 Oct 01; 23(26):8978-88. PMID: 14523100.
      View in: PubMed
    34. Sohal VS, Keist R, Rudolph U, Huguenard JR. Dynamic GABA(A) receptor subtype-specific modulation of the synchrony and duration of thalamic oscillations. J Neurosci. 2003 May 01; 23(9):3649-57. PMID: 12736336.
      View in: PubMed
    35. Sohal VS, Huguenard JR. It takes T to tango. Neuron. 2001 Jul 19; 31(1):3-4. PMID: 11498042.
      View in: PubMed
    36. Sohal VS, Hasselmo ME. A model for experience-dependent changes in the responses of inferotemporal neurons. Network. 2000 Aug; 11(3):169-90. PMID: 11014667.
      View in: PubMed
    37. Sohal VS, Huntsman MM, Huguenard JR. Reciprocal inhibitory connections regulate the spatiotemporal properties of intrathalamic oscillations. J Neurosci. 2000 Mar 01; 20(5):1735-45. PMID: 10684875.
      View in: PubMed
    38. Sohal VS, Huguenard JR. Long-range connections synchronize rather than spread intrathalamic oscillations: computational modeling and in vitro electrophysiology. J Neurophysiol. 1998 Oct; 80(4):1736-51. PMID: 9772235.
      View in: PubMed
    39. Sohal VS, Hasselmo ME. Changes in GABAB modulation during a theta cycle may be analogous to the fall of temperature during annealing. Neural Comput. 1998 May 15; 10(4):869-82. PMID: 9573410.
      View in: PubMed
    40. Sohal VS, Cox CL, Huguenard JR. Localization of CCK receptors in thalamic reticular neurons: a modeling study. J Neurophysiol. 1998 May; 79(5):2820-4. PMID: 9582249.
      View in: PubMed
    41. Sohal VS, Hasselmo ME. GABA(B) modulation improves sequence disambiguation in computational models of hippocampal region CA3. Hippocampus. 1998; 8(2):171-93. PMID: 9572723.
      View in: PubMed
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