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    Heidi Kirsch, MD, MS

    TitleAssociate Professor of Clinical
    SchoolUCSF School of Medicine
    DepartmentNeurology
    Address400 Parnassus Ave, UC Clinics
    San Francisco CA 94143
    Phone415-353-2437

       Overview 
       Overview
      Dr. Heidi Kirsch is a specialist in mapping epileptic activity and functional areas in the brain using a combination of magnetoencephalography (MEG) and electroencephalography (EEG) for the purposes of planning epilepsy surgery and other types of brain surgery. She is the Clinical Director and Associate Director of Research for the UCSF Biomagnetic Imaging Laboratory (MEG lab). She is a specialist in epilepsy treatment. In her research, she studies new methods of brain mapping and the ways in which seizures spread in the brain. She also works on a multicenter clinical trial of gamma knife (radiosurgery) versus standard brain surgery for temporal lobe epilepsy. She is board certified in neurology and clinical neurophysiology.
      Kirsch earned an undergraduate degree magna cum laude at Harvard and a master's degree in Health and Medical Sciences and a medical degree from the Joint Medical Program offered by the University of California at Berkeley and UCSF. She completed an internship at Georgetown University and a neurology residency at Johns Hopkins Hospital, where she was a fellow in clinical neurophysiology, epilepsy and cognitive neurology. During her fellowship, she was a volunteer to the Cognitive Neuroscience Section of the National Institutes of Health (NIH). She is a member and past president of the board of directors of the Epilepsy Foundation of Northern California, and a member of the American Neurological Association, the American Academy of Neurology and the American Epilepsy Society. She serves as an ad hoc reviewer for several journals, including the Annals of Neurology and Neurology. She joined UCSF Medical Center in 2002 and is a UCSF associate professor of clinical neurology and radiology and biomedical imaging.


       Bibliographic 
       Publications
      Publications by year:
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      1. Winawer MR, Connors R. Evidence for a shared genetic susceptibility to migraine and epilepsy. Epilepsia. 2013 Feb; 54(2):288-95.
        View in: PubMed
      2. Tarapore PE, Martino J, Guggisberg AG, Owen J, Honma SM, Findlay A, Berger MS, Kirsch HE, Nagarajan SS. Magnetoencephalographic imaging of resting-state functional connectivity predicts postsurgical neurological outcome in brain gliomas. Neurosurgery. 2012 Nov; 71(5):1012-22.
        View in: PubMed
      3. Nesbitt G, McKenna K, Mays V, Carpenter A, Miller K, Williams M. The Epilepsy Phenome/Genome Project (EPGP) informatics platform. Int J Med Inform. 2013 Apr; 82(4):248-59.
        View in: PubMed
      4. Ventura MI, Baynes K, Sigvardt KA, Unruh AM, Acklin SS, Kirsch HE, Disbrow EA. Hemispheric asymmetries and prosodic emotion recognition deficits in Parkinson's disease. Neuropsychologia. 2012 Jul; 50(8):1936-45.
        View in: PubMed
      5. Findlay AM, Ambrose JB, Cahn-Weiner DA, Houde JF, Honma S, Hinkley LB, Berger MS, Nagarajan SS, Kirsch HE. Dynamics of hemispheric dominance for language assessed by magnetoencephalographic imaging. Ann Neurol. 2012 May; 71(5):668-86.
        View in: PubMed
      6. Knutson KM, Krueger F, Dal Monte O, Raymont V, Snyder AD, Kirsch HE, Wassermann EM, Grafman J. Cognitive Neuroscience. Gustatory cortical lesions affect motivation for snack foods. 2012; 2(3):131-8.
      7. Poncelet A, Hirsh D, Arky R, Mazotti L, Ogur B, Bor D, Brooks K, Erickson J, Hansen L, Wamsley M, Shore W, Cohen P, Kirsch H, Elvin D, Gaufberg E, Cave M-T, Clandinin J, Cave A, Batalden M, Lai C, Polevoi S, Stein J, Ghosh A, Maa J, Theodore P, Park P, Bokser S, Robertson P, Griswold T, Meyer R, Schauer R, Konkin J, Strasser S, Strasser R, Worley P, Greenhill J, Hauer K, Krupat E, Tong L, Teherani A, Krupat E. The Alliance for Clinical Education Guidebook for Clerkship Directors. Longitudinal Integrated Clerkships. 2012; 173-224.
      8. Burgess RC, Funke ME, Bowyer SM, Lewine JD, Kirsch HE, Bagic AI. American Clinical Magnetoencephalography Society Clinical Practice Guideline 2: presurgical functional brain mapping using magnetic evoked fields. J Clin Neurophysiol. 2011 Aug; 28(4):355-61.
        View in: PubMed
      9. Poncelet A, Bokser S, Calton B, Hauer KE, Kirsch H, Jones T, Lai CJ, Mazotti L, Shore W, Teherani A, Tong L, Wamsley M, Robertson P. Development of a longitudinal integrated clerkship at an academic medical center. Med Educ Online. 2011; 16.
        View in: PubMed
      10. Martino J, Honma SM, Findlay AM, Guggisberg AG, Owen JP, Kirsch HE, Berger MS, Nagarajan SS. Resting functional connectivity in patients with brain tumors in eloquent areas. Ann Neurol. 2011 Mar; 69(3):521-32.
        View in: PubMed
      11. Kirsch HE, Crone NE. GL Krauss, RS Fisher, P Kaplan (Eds.). The Johns Hopkins Atlas of Digital EEG: An Interactive Training Guide. The '10-20' system and cortical topography. 2011.
      12. Flinker A, Chang EF, Kirsch HE, Barbaro NM, Crone NE, Knight RT. Single-trial speech suppression of auditory cortex activity in humans. J Neurosci. 2010 Dec 8; 30(49):16643-50.
        View in: PubMed
      13. Mazotti L, Kirsch HE, O'Brien B. Medical Education Development. Improving integration of clinical clerkship didactic curriculum. 2010; 1(1).
      14. Lopour BA, Tasoglu S, Kirsch HE, Sleigh JW, Szeri AJ. A continuous mapping of sleep states through association of EEG with a mesoscale cortical model. J Comput Neurosci. 2011 Apr; 30(2):471-87.
        View in: PubMed
      15. Chang EF, Edwards E, Nagarajan SS, Fogelson N, Dalal SS, Canolty RT, Kirsch HE, Barbaro NM, Knight RT. Cortical spatio-temporal dynamics underlying phonological target detection in humans. J Cogn Neurosci. 2011 Jun; 23(6):1437-46.
        View in: PubMed
      16. Wu JY, Salamon N, Kirsch HE, Mantle MM, Nagarajan SS, Kurelowech L, Aung MH, Sankar R, Shields WD, Mathern GW. Noninvasive testing, early surgery, and seizure freedom in tuberous sclerosis complex. Neurology. 2010 Feb 2; 74(5):392-8.
        View in: PubMed
      17. Kaiboriboon K, Nagarajan S, Mantle M, Kirsch HE. Interictal MEG/MSI in intractable mesial temporal lobe epilepsy: spike yield and characterization. Clin Neurophysiol. 2010 Mar; 121(3):325-31.
        View in: PubMed
      18. Edwards E, Nagarajan SS, Dalal SS, Canolty RT, Kirsch HE, Barbaro NM, Knight RT. Spatiotemporal imaging of cortical activation during verb generation and picture naming. Neuroimage. 2010 Mar; 50(1):291-301.
        View in: PubMed
      19. Chang EF, Nagarajan SS, Mantle M, Barbaro NM, Kirsch HE. Magnetic source imaging for the surgical evaluation of electroencephalography-confirmed secondary bilateral synchrony in intractable epilepsy. J Neurosurg. 2009 Dec; 111(6):1248-56.
        View in: PubMed
      20. Hixson JD, Kirsch HE. The effects of epilepsy and its treatments on affect and emotion. Neurocase. 2009 Jun; 15(3):206-16.
        View in: PubMed
      21. Voss LJ, Sleigh JW, Barnard JP, Kirsch HE. The howling cortex: seizures and general anesthetic drugs. Anesth Analg. 2008 Nov; 107(5):1689-703.
        View in: PubMed
      22. Kirsch HE, Grossman M. Tracing the roots and routes of cognitive dysfunction in epilepsy. Neurology. 2008 Dec 2; 71(23):1854-5.
        View in: PubMed
      23. Nagarajan S, Kirsch H, Lin P, Findlay A, Honma S, Berger MS. Preoperative localization of hand motor cortex by adaptive spatial filtering of magnetoencephalography data. J Neurosurg. 2008 Aug; 109(2):228-37.
        View in: PubMed
      24. Dalal SS, Edwards E, Kirsch HE, Barbaro NM, Knight RT, Nagarajan SS. Localization of neurosurgically implanted electrodes via photograph-MRI-radiograph coregistration. J Neurosci Methods. 2008 Sep 15; 174(1):106-15.
        View in: PubMed
      25. Koch AE, Kirsch H, Reuter M, Warninghoff V, Rieckert H, Deuschl G. Prevalence of patent foramen ovale (PFO) and MRI-lesions in mild neurological decompression sickness (type B-DCS/AGE). Undersea Hyperb Med. 2008 May-Jun; 35(3):197-205.
        View in: PubMed
      26. Kramer MA, Kolaczyk ED, Kirsch HE. Emergent network topology at seizure onset in humans. Epilepsy Res. 2008 May; 79(2-3):173-86.
        View in: PubMed
      27. Guggisberg AG, Honma SM, Findlay AM, Dalal SS, Kirsch HE, Berger MS, Nagarajan SS. Mapping functional connectivity in patients with brain lesions. Ann Neurol. 2008 Feb; 63(2):193-203.
        View in: PubMed
      28. Dalal SS, Guggisberg AG, Edwards E, Sekihara K, Findlay AM, Canolty RT, Berger MS, Knight RT, Barbaro NM, Kirsch HE, Nagarajan SS. Five-dimensional neuroimaging: localization of the time-frequency dynamics of cortical activity. Neuroimage. 2008 May 1; 40(4):1686-700.
        View in: PubMed
      29. Canolty RT, Soltani M, Dalal SS, Edwards E, Dronkers NF, Nagarajan SS, Kirsch HE, Barbaro NM, Knight RT. Spatiotemporal dynamics of word processing in the human brain. Front Neurosci. 2007 Nov; 1(1):185-96.
        View in: PubMed
      30. Guggisberg AG, Kirsch HE, Mantle MM, Barbaro NM, Nagarajan SS. Fast oscillations associated with interictal spikes localize the epileptogenic zone in patients with partial epilepsy. Neuroimage. 2008 Jan 15; 39(2):661-8.
        View in: PubMed
      31. Kirsch HE, Zhu Z, Honma S, Findlay A, Berger MS, Nagarajan SS. Predicting the location of mouth motor cortex in patients with brain tumors by using somatosensory evoked field measurements. J Neurosurg. 2007 Sep; 107(3):481-7.
        View in: PubMed
      32. Kirsch HE, Mantle M, Nagarajan SS. Concordance between routine interictal magnetoencephalography and simultaneous scalp electroencephalography in a sample of patients with epilepsy. J Clin Neurophysiol. 2007 Jun; 24(3):215-31.
        View in: PubMed
      33. Wang Y, Greenwood JS, Calcagnotto ME, Kirsch HE, Barbaro NM, Baraban SC. Neocortical hyperexcitability in a human case of tuberous sclerosis complex and mice lacking neuronal expression of TSC1. Ann Neurol. 2007 Feb; 61(2):139-52.
        View in: PubMed
      34. Dalal SS, Guggisberg AG, Edwards E, Sekihara K, Findlay AM, Canolty RT, Knight RT, Barbaro NM, Kirsch HE, Nagarajan SS. Spatial localization of cortical time-frequency dynamics. Conf Proc IEEE Eng Med Biol Soc. 2007; 2007:4941-4.
        View in: PubMed
      35. Kirsch HE, Crone NE. GL Krauss, RS Fisher (Eds.). The Johns Hopkins Atlas of Digital EEG: An Interactive Training Guide. The '10-20' system and cortical topography. 2007.
      36. Kramer MA, Szeri AJ, Sleigh JW, Kirsch HE. Mechanisms of seizure propagation in a cortical model. J Comput Neurosci. 2007 Feb; 22(1):63-80.
        View in: PubMed
      37. Canolty RT, Edwards E, Dalal SS, Soltani M, Nagarajan SS, Kirsch HE, Berger MS, Barbaro NM, Knight RT. High gamma power is phase-locked to theta oscillations in human neocortex. Science. 2006 Sep 15; 313(5793):1626-8.
        View in: PubMed
      38. Kirsch HE, Robinson SE, Mantle M, Nagarajan S. Automated localization of magnetoencephalographic interictal spikes by adaptive spatial filtering. Clin Neurophysiol. 2006 Oct; 117(10):2264-71.
        View in: PubMed
      39. Kramer MA, Lopour BA, Kirsch HE, Szeri AJ. Bifurcation control of a seizing human cortex. Phys Rev E Stat Nonlin Soft Matter Phys. 2006 Apr; 73(4 Pt 1):041928.
        View in: PubMed
      40. Josephson SA, Kirsch HE. Complex visual hallucinations as post-ictal cortical release phenomena. Neurocase. 2006 Apr; 12(2):107-10.
        View in: PubMed
      41. Kirsch HE. Social cognition and epilepsy surgery. Epilepsy Behav. 2006 Feb; 8(1):71-80.
        View in: PubMed
      42. Kirsch HE, Walker JA, Winstanley FS, Hendrickson R, Wong ST, Barbaro NM, Laxer KD, Garcia PA. Limitations of Wada memory asymmetry as a predictor of outcomes after temporal lobectomy. Neurology. 2005 Sep 13; 65(5):676-80.
        View in: PubMed
      43. Kramer MA, Kirsch HE, Szeri AJ. Pathological pattern formation and cortical propagation of epileptic seizures. J R Soc Interface. 2005 Mar 22; 2(2):113-27.
        View in: PubMed
      44. Robinson SE, Nagarajan SS, Mantle M, Gibbons V, Kirsch H. Localization of interictal spikes using SAM(g2) and dipole fit. Neurol Clin Neurophysiol. 2004; 2004:74.
        View in: PubMed
      45. Kirsch HE, Sepkuty JP, Crone NE. Multimodal functional mapping of sensorimotor cortex prior to resection of an epileptogenic perirolandic lesion. Epilepsy Behav. 2004 Jun; 5(3):407-10.
        View in: PubMed
      46. Kirsch HE. The utility of a federated web-based information management system in an epilepsy center. Neuroinformatics. 2004; 2(1):119-21.
        View in: PubMed
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