Sign in to see private stats on your profile page — or add photo, interests, videos, mentoring, etc.

    Heidi Kirsch, MD, MS

    SchoolUCSF School of Medicine
    Address400 Parnassus Avenue
    San Francisco CA 94117
    vCardDownload vCard

      Collapse Biography 
      Collapse Education and Training
      Harvard UniversityA.B.Biological Anthropology1991
      University of California, BerkeleyM.S.School of Public Health (Joint Medical Program)1994
      University of California, San FranciscoM.D. Medicine1996
      GeorgetownResidency (PGY-1)Medicine/Transitional Year1997
      Johns HopkinsResidency, Chief residencyNeurology2000
      Johns HopkinsFellowshipEpilepsy and Clinical Neurophysiology2002

      Collapse Overview 
      Collapse Overview
      Dr. Heidi Kirsch is a specialist in mapping epileptic activity and functional areas in the brain using magnetoencephalography (MEG) for the purposes of planning epilepsy surgery and other types of brain surgery. She is the Clinical Director and Associate Director of Research for the UCSF Biomagnetic Imaging Laboratory (MEG lab). She is a specialist in epilepsy treatment (epileptology). In her research, she studies new methods of brain mapping and the ways in which seizures spread in the brain. She also worked on a multicenter clinical trial of gamma knife (radiosurgery) versus standard brain surgery for temporal lobe epilepsy and on a multicenter study of epilepsy genetics. She is board certified in neurology and clinical neurophysiology.
      Kirsch earned an undergraduate degree magna cum laude at Harvard and a master's degree in Health and Medical Sciences and a medical degree from the Joint Medical Program offered by the University of California at Berkeley and UCSF. She completed an internship at Georgetown University and a neurology residency at Johns Hopkins Hospital, where she was a fellow in clinical neurophysiology, epilepsy and cognitive neurology. During her fellowship, she was a volunteer to the Cognitive Neuroscience Section of the National Institutes of Health (NIH). She is a member and past president of the board of directors of the Epilepsy Foundation of Northern California, and a member of the American Neurological Association, the American Academy of Neurology and the American Epilepsy Society. She serves as an ad hoc reviewer for several journals, including the Annals of Neurology and Neurology. She joined UCSF Medical Center in 2002 and is a UCSF associate professor of clinical neurology and radiology and biomedical imaging.

      Collapse ORNG Applications 
      Collapse Websites
      Collapse Global Health

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Englot DJ, Rolston JD, Wang DD, Kirsch HE, Nagarajan SS, Chang EF. 206 Spikes, Slowing, and Functional Connectivity: Multimodal Magnetoencephalography in Epilepsy Surgery. Neurosurgery. 2016 Aug; 63 Suppl 1:181. PMID: 27399485.
        View in: PubMed
      2. Dürschmid S, Edwards E, Reichert C, Dewar C, Hinrichs H, Heinze HJ, Kirsch HE, Dalal SS, Deouell LY, Knight RT. Hierarchy of prediction errors for auditory events in human temporal and frontal cortex. Proc Natl Acad Sci U S A. 2016 Jun 14; 113(24):6755-60. PMID: 27247381.
        View in: PubMed
      3. Englot DJ, Nagarajan SS, Wang DD, Rolston JD, Mizuiri D, Honma SM, Mantle M, Tarapore PE, Knowlton RC, Chang EF, Kirsch HE. The sensitivity and significance of lateralized interictal slow activity on magnetoencephalography in focal epilepsy. Epilepsy Res. 2016 Mar; 121:21-8. PMID: 26871959.
        View in: PubMed
      4. Selvaraj P, Sleigh JW, Kirsch HE, Szeri AJ. Closed-loop feedback control and bifurcation analysis of epileptiform activity via optogenetic stimulation in a mathematical model of human cortex. Phys Rev E Stat Nonlin Soft Matter Phys. 2016 Jan; 93(1-1):012416. PMID: 26871110.
        View in: PubMed
      5. Englot DJ, Hinkley LB, Kort NS, Imber BS, Mizuiri D, Honma SM, Findlay AM, Garrett C, Cheung PL, Mantle M, Tarapore PE, Knowlton RC, Chang EF, Kirsch HE, Nagarajan SS. Global and regional functional connectivity maps of neural oscillations in focal epilepsy. Brain. 2015 Aug; 138(Pt 8):2249-62. PMID: 25981965.
        View in: PubMed
      6. Englot DJ, Nagarajan SS, Imber BS, Raygor KP, Honma SM, Mizuiri D, Mantle M, Knowlton RC, Kirsch HE, Chang EF. Epileptogenic zone localization using magnetoencephalography predicts seizure freedom in epilepsy surgery. Epilepsia. 2015 Jun; 56(6):949-58. PMID: 25921215; PMCID: PMC4457690 [Available on 06/01/16].
      7. Dadok VM, Kirsch HE, Sleigh JW, Lopour BA, Szeri AJ. A probabilistic method for determining cortical dynamics during seizures. J Comput Neurosci. 2015 Jun; 38(3):559-75. PMID: 25851500.
        View in: PubMed
      8. Selvaraj P, Sleigh JW, Kirsch HE, Szeri AJ. Optogenetic induced epileptiform activity in a model human cortex. Springerplus. 2015; 4:155. PMID: 25897410; PMCID: PMC4395626.
      9. Carlson C, Dugan P, Kirsch HE, Friedman D. Sex differences in seizure types and symptoms. Epilepsy Behav. 2014 Dec; 41:103-8. PMID: 25461198; PMCID: PMC4267158 [Available on 12/01/15].
      10. Dugan P, Carlson C, Bluvstein J, Chong DJ, Friedman D, Kirsch HE. Auras in generalized epilepsy. Neurology. 2014 Oct 14; 83(16):1444-9. PMID: 25230998; PMCID: PMC4206156.
      11. Dadok VM, Kirsch HE, Sleigh JW, Lopour BA, Szeri AJ. A probabilistic framework for a physiological representation of dynamically evolving sleep state. J Comput Neurosci. 2014 Aug; 37(1):105-24. PMID: 24363031.
        View in: PubMed
      12. Selvaraj P, Sleigh JW, Freeman WJ, Kirsch HE, Szeri AJ. Open loop optogenetic control of simulated cortical epileptiform activity. J Comput Neurosci. 2014 Jun; 36(3):515-25. PMID: 24174320.
        View in: PubMed
      13. Vossel KA, Beagle AJ, Rabinovici GD, Shu H, Lee SE, Naasan G, Hegde M, Cornes SB, Henry ML, Nelson AB, Seeley WW, Geschwind MD, Gorno-Tempini ML, Shih T, Kirsch HE, Garcia PA, Miller BL, Mucke L. Seizures and epileptiform activity in the early stages of Alzheimer disease. JAMA Neurol. 2013 Sep 1; 70(9):1158-66. PMID: 23835471; PMCID: PMC4013391.
      14. Allen AS, Berkovic SF, Cossette P, Delanty N, Dlugos D, Eichler EE, Epstein MP, Glauser T, Goldstein DB, Han Y, Heinzen EL, Hitomi Y, Howell KB, Johnson MR, Kuzniecky R, Lowenstein DH, Lu YF, Madou MR, Marson AG, Mefford HC, Esmaeeli Nieh S, O'Brien TJ, Ottman R, Petrovski S, Poduri A, Ruzzo EK, Scheffer IE, Sherr EH, Yuskaitis CJ, Abou-Khalil B, Alldredge BK, Bautista JF, Berkovic SF, Boro A, Cascino GD, Consalvo D, Crumrine P, Devinsky O, Dlugos D, Epstein MP, Fiol M, Fountain NB, French J, Friedman D, Geller EB, Glauser T, Glynn S, Haut SR, Hayward J, Helmers SL, Joshi S, Kanner A, Kirsch HE, Knowlton RC, Kossoff EH, Kuperman R, Kuzniecky R, Lowenstein DH, McGuire SM, Motika PV, Novotny EJ, Ottman R, Paolicchi JM, Parent JM, Park K, Poduri A, Scheffer IE, Shellhaas RA, Sherr EH, Shih JJ, Singh R, Sirven J, Smith MC, Sullivan J, Lin Thio L, Venkat A, Vining EP, Von Allmen GK, Weisenberg JL, Widdess-Walsh P, Winawer MR. De novo mutations in epileptic encephalopathies. Nature. 2013 Sep 12; 501(7466):217-21. PMID: 23934111; PMCID: PMC3773011.
      15. Abou-Khalil B, Alldredge B, Bautista J, Berkovic S, Bluvstein J, Boro A, Cascino G, Consalvo D, Cristofaro S, Crumrine P, Devinsky O, Dlugos D, Epstein M, Fahlstrom R, Fiol M, Fountain N, Fox K, French J, Freyer Karn C, Friedman D, Geller E, Glauser T, Glynn S, Haas K, Haut S, Hayward J, Helmers S, Joshi S, Kanner A, Kirsch H, Knowlton R, Kossoff E, Kuperman R, Kuzniecky R, Lowenstein D, McGuire S, Motika P, Nesbitt G, Novotny E, Ottman R, Paolicchi J, Parent J, Park K, Poduri A, Risch N, Sadleir L, Scheffer I, Shellhaas R, Sherr E, Shih JJ, Shinnar S, Singh R, Sirven J, Smith M, Sullivan J, Thio LL, Venkat A, Vining E, von Allmen G, Weisenberg J, Widdess-Walsh P, Winawer M. The epilepsy phenome/genome project. Clin Trials. 2013 Aug; 10(4):568-86. PMID: 23818435.
        View in: PubMed
      16. Winawer MR, Connors R. Evidence for a shared genetic susceptibility to migraine and epilepsy. Epilepsia. 2013 Feb; 54(2):288-95. PMID: 23294289; PMCID: PMC3566298.
      17. Epi4K and EPGP Investigators. . Nature. De novo mutation in epileptic encephalopathies. 2013; (in press).
      18. Vossel KA, Beagle AJ, Rabinovici GD, Shu H, Lee SE, Nassan G, Hegde M, Cornes SB, Henry ML, Nelson AB, Seeley WW, Geschwind MD, Gorno-Tempini, ML, Shih T, Kirsch HE, Garcia PA, Miller BL, Mucke L. . . JAMA Neurology. Seizures and epileptiform activity in the early stages of Alzheimer’s disease. 2013; (in press).
      19. Tarapore PE, Martino J, Guggisberg AG, Owen J, Honma SM, Findlay A, Berger MS, Kirsch HE, Nagarajan SS. Magnetoencephalographic imaging of resting-state functional connectivity predicts postsurgical neurological outcome in brain gliomas. Neurosurgery. 2012 Nov; 71(5):1012-22. PMID: 22895403; PMCID: PMC3761085.
      20. Knutson KM, Krueger F, Dal Monte O, Raymont V, Snyder AD, Kirsch HE, Wassermann EM, Grafman J. Gustatory cortical lesions affect motivation for snack foods. Cogn Neurosci. 2012; 3(2):131-8. PMID: 24168694.
        View in: PubMed
      21. Nesbitt G, McKenna K, Mays V, Carpenter A, Miller K, Williams M. The Epilepsy Phenome/Genome Project (EPGP) informatics platform. Int J Med Inform. 2013 Apr; 82(4):248-59. PMID: 22579394; PMCID: PMC3655424.
      22. Ventura MI, Baynes K, Sigvardt KA, Unruh AM, Acklin SS, Kirsch HE, Disbrow EA. Hemispheric asymmetries and prosodic emotion recognition deficits in Parkinson's disease. Neuropsychologia. 2012 Jul; 50(8):1936-45. PMID: 22564479.
        View in: PubMed
      23. Findlay AM, Ambrose JB, Cahn-Weiner DA, Houde JF, Honma S, Hinkley LB, Berger MS, Nagarajan SS, Kirsch HE. Dynamics of hemispheric dominance for language assessed by magnetoencephalographic imaging. Ann Neurol. 2012 May; 71(5):668-86. PMID: 22522481; PMCID: PMC3380661.
      24. Knutson KM, Krueger F, Dal Monte O, Raymont V, Snyder AD, Kirsch HE, Wassermann EM, Grafman J. . Cognitive Neuroscience. Gustatory cortical lesions affect motivation for snack foods. 2012; 2(3):131-8.
      25. Poncelet A, Hirsh D, Arky R, Mazotti L, Ogur B, Bor D, Brooks K, Erickson J, Hansen L, Wamsley M, Shore W, Cohen P, Kirsch H, Elvin D, Gaufberg E, Cave M-T, Clandinin J, Cave A, Batalden M, Lai C, Polevoi S, Stein J, Ghosh A, Maa J, Theodore P, Park P, Bokser S, Robertson P, Griswold T, Meyer R, Schauer R, Konkin J, Strasser S, Strasser R, Worley P, Greenhill J, Hauer K, Krupat E, Tong L, Teherani A, Krupat E. . The Alliance for Clinical Education Guidebook for Clerkship Directors. Longitudinal Integrated Clerkships. 2012; 173-224.
      26. Burgess RC, Funke ME, Bowyer SM, Lewine JD, Kirsch HE, Bagic AI. American Clinical Magnetoencephalography Society Clinical Practice Guideline 2: presurgical functional brain mapping using magnetic evoked fields. J Clin Neurophysiol. 2011 Aug; 28(4):355-61. PMID: 21811122; PMCID: PMC3366725.
      27. Poncelet A, Bokser S, Calton B, Hauer KE, Kirsch H, Jones T, Lai CJ, Mazotti L, Shore W, Teherani A, Tong L, Wamsley M, Robertson P. Development of a longitudinal integrated clerkship at an academic medical center. Med Educ Online. 2011; 16. PMID: 21475642; PMCID: PMC3071870.
      28. Martino J, Honma SM, Findlay AM, Guggisberg AG, Owen JP, Kirsch HE, Berger MS, Nagarajan SS. Resting functional connectivity in patients with brain tumors in eloquent areas. Ann Neurol. 2011 Mar; 69(3):521-32. PMID: 21400562; PMCID: PMC4090361.
      29. Kirsch HE, Crone NE. . GL Krauss, RS Fisher, P Kaplan (Eds.). The Johns Hopkins Atlas of Digital EEG: An Interactive Training Guide. The '10-20' system and cortical topography. 2011.
      30. Flinker A, Chang EF, Kirsch HE, Barbaro NM, Crone NE, Knight RT. Single-trial speech suppression of auditory cortex activity in humans. J Neurosci. 2010 Dec 8; 30(49):16643-50. PMID: 21148003; PMCID: PMC3010242.
      31. Mazotti L, Kirsch HE, O'Brien B. . Medical Education Development. Improving integration of clinical clerkship didactic curriculum. 2010; 1(1).
      32. Lopour BA, Tasoglu S, Kirsch HE, Sleigh JW, Szeri AJ. A continuous mapping of sleep states through association of EEG with a mesoscale cortical model. J Comput Neurosci. 2011 Apr; 30(2):471-87. PMID: 20809258; PMCID: PMC3058368.
      33. Chang EF, Edwards E, Nagarajan SS, Fogelson N, Dalal SS, Canolty RT, Kirsch HE, Barbaro NM, Knight RT. Cortical spatio-temporal dynamics underlying phonological target detection in humans. J Cogn Neurosci. 2011 Jun; 23(6):1437-46. PMID: 20465359; PMCID: PMC3895406.
      34. Wu JY, Salamon N, Kirsch HE, Mantle MM, Nagarajan SS, Kurelowech L, Aung MH, Sankar R, Shields WD, Mathern GW. Noninvasive testing, early surgery, and seizure freedom in tuberous sclerosis complex. Neurology. 2010 Feb 2; 74(5):392-8. PMID: 20124204; PMCID: PMC2816007.
      35. Kaiboriboon K, Nagarajan S, Mantle M, Kirsch HE. Interictal MEG/MSI in intractable mesial temporal lobe epilepsy: spike yield and characterization. Clin Neurophysiol. 2010 Mar; 121(3):325-31. PMID: 20064741; PMCID: PMC2821956.
      36. Edwards E, Nagarajan SS, Dalal SS, Canolty RT, Kirsch HE, Barbaro NM, Knight RT. Spatiotemporal imaging of cortical activation during verb generation and picture naming. Neuroimage. 2010 Mar; 50(1):291-301. PMID: 20026224; PMCID: PMC2957470.
      37. Chang EF, Nagarajan SS, Mantle M, Barbaro NM, Kirsch HE. Magnetic source imaging for the surgical evaluation of electroencephalography-confirmed secondary bilateral synchrony in intractable epilepsy. J Neurosurg. 2009 Dec; 111(6):1248-56. PMID: 19575574; PMCID: PMC3151560.
      38. Hixson JD, Kirsch HE. The effects of epilepsy and its treatments on affect and emotion. Neurocase. 2009 Jun; 15(3):206-16. PMID: 19204849.
        View in: PubMed
      39. Voss LJ, Sleigh JW, Barnard JP, Kirsch HE. The howling cortex: seizures and general anesthetic drugs. Anesth Analg. 2008 Nov; 107(5):1689-703. PMID: 18931234.
        View in: PubMed
      40. Kirsch HE, Grossman M. Tracing the roots and routes of cognitive dysfunction in epilepsy. Neurology. 2008 Dec 2; 71(23):1854-5. PMID: 18946000.
        View in: PubMed
      41. Nagarajan S, Kirsch H, Lin P, Findlay A, Honma S, Berger MS. Preoperative localization of hand motor cortex by adaptive spatial filtering of magnetoencephalography data. J Neurosurg. 2008 Aug; 109(2):228-37. PMID: 18671634.
        View in: PubMed
      42. Dalal SS, Edwards E, Kirsch HE, Barbaro NM, Knight RT, Nagarajan SS. Localization of neurosurgically implanted electrodes via photograph-MRI-radiograph coregistration. J Neurosci Methods. 2008 Sep 15; 174(1):106-15. PMID: 18657573; PMCID: PMC2695765.
      43. Koch AE, Kirsch H, Reuter M, Warninghoff V, Rieckert H, Deuschl G. Prevalence of patent foramen ovale (PFO) and MRI-lesions in mild neurological decompression sickness (type B-DCS/AGE). Undersea Hyperb Med. 2008 May-Jun; 35(3):197-205. PMID: 18619115.
        View in: PubMed
      44. Kramer MA, Kolaczyk ED, Kirsch HE. Emergent network topology at seizure onset in humans. Epilepsy Res. 2008 May; 79(2-3):173-86. PMID: 18359200.
        View in: PubMed
      45. Guggisberg AG, Honma SM, Findlay AM, Dalal SS, Kirsch HE, Berger MS, Nagarajan SS. Mapping functional connectivity in patients with brain lesions. Ann Neurol. 2008 Feb; 63(2):193-203. PMID: 17894381; PMCID: PMC3646715.
      46. Dalal SS, Guggisberg AG, Edwards E, Sekihara K, Findlay AM, Canolty RT, Berger MS, Knight RT, Barbaro NM, Kirsch HE, Nagarajan SS. Five-dimensional neuroimaging: localization of the time-frequency dynamics of cortical activity. Neuroimage. 2008 May 1; 40(4):1686-700. PMID: 18356081; PMCID: PMC2426929.
      47. Canolty RT, Soltani M, Dalal SS, Edwards E, Dronkers NF, Nagarajan SS, Kirsch HE, Barbaro NM, Knight RT. Spatiotemporal dynamics of word processing in the human brain. Front Neurosci. 2007 Nov; 1(1):185-96. PMID: 18982128; PMCID: PMC2518055.
      48. Guggisberg AG, Kirsch HE, Mantle MM, Barbaro NM, Nagarajan SS. Fast oscillations associated with interictal spikes localize the epileptogenic zone in patients with partial epilepsy. Neuroimage. 2008 Jan 15; 39(2):661-8. PMID: 17977022; PMCID: PMC2742724.
      49. Kirsch HE, Zhu Z, Honma S, Findlay A, Berger MS, Nagarajan SS. Predicting the location of mouth motor cortex in patients with brain tumors by using somatosensory evoked field measurements. J Neurosurg. 2007 Sep; 107(3):481-7. PMID: 17886544.
        View in: PubMed
      50. Kirsch HE, Mantle M, Nagarajan SS. Concordance between routine interictal magnetoencephalography and simultaneous scalp electroencephalography in a sample of patients with epilepsy. J Clin Neurophysiol. 2007 Jun; 24(3):215-31. PMID: 17545825; PMCID: PMC4096347.
      51. Wang Y, Greenwood JS, Calcagnotto ME, Kirsch HE, Barbaro NM, Baraban SC. Neocortical hyperexcitability in a human case of tuberous sclerosis complex and mice lacking neuronal expression of TSC1. Ann Neurol. 2007 Feb; 61(2):139-52. PMID: 17279540.
        View in: PubMed
      52. Dalal SS, Guggisberg AG, Edwards E, Sekihara K, Findlay AM, Canolty RT, Knight RT, Barbaro NM, Kirsch HE, Nagarajan SS. Spatial localization of cortical time-frequency dynamics. Conf Proc IEEE Eng Med Biol Soc. 2007; 2007:4941-4. PMID: 18003115.
        View in: PubMed
      53. Kirsch HE, Crone NE. . GL Krauss, RS Fisher (Eds.). The Johns Hopkins Atlas of Digital EEG: An Interactive Training Guide. The '10-20' system and cortical topography. 2007.
      54. Kramer MA, Szeri AJ, Sleigh JW, Kirsch HE. Mechanisms of seizure propagation in a cortical model. J Comput Neurosci. 2007 Feb; 22(1):63-80. PMID: 16998642.
        View in: PubMed
      55. Canolty RT, Edwards E, Dalal SS, Soltani M, Nagarajan SS, Kirsch HE, Berger MS, Barbaro NM, Knight RT. High gamma power is phase-locked to theta oscillations in human neocortex. Science. 2006 Sep 15; 313(5793):1626-8. PMID: 16973878; PMCID: PMC2628289.
      56. Kirsch HE, Robinson SE, Mantle M, Nagarajan S. Automated localization of magnetoencephalographic interictal spikes by adaptive spatial filtering. Clin Neurophysiol. 2006 Oct; 117(10):2264-71. PMID: 16893680.
        View in: PubMed
      57. Kramer MA, Lopour BA, Kirsch HE, Szeri AJ. Bifurcation control of a seizing human cortex. Phys Rev E Stat Nonlin Soft Matter Phys. 2006 Apr; 73(4 Pt 1):041928. PMID: 16711857.
        View in: PubMed
      58. Josephson SA, Kirsch HE. Complex visual hallucinations as post-ictal cortical release phenomena. Neurocase. 2006 Apr; 12(2):107-10. PMID: 16714243.
        View in: PubMed
      59. Kirsch HE. Social cognition and epilepsy surgery. Epilepsy Behav. 2006 Feb; 8(1):71-80. PMID: 16253567.
        View in: PubMed
      60. Kirsch HE, Walker JA, Winstanley FS, Hendrickson R, Wong ST, Barbaro NM, Laxer KD, Garcia PA. Limitations of Wada memory asymmetry as a predictor of outcomes after temporal lobectomy. Neurology. 2005 Sep 13; 65(5):676-80. PMID: 16157898.
        View in: PubMed
      61. Kramer MA, Kirsch HE, Szeri AJ. Pathological pattern formation and cortical propagation of epileptic seizures. J R Soc Interface. 2005 Mar 22; 2(2):113-27. PMID: 16849171; PMCID: PMC1578262.
      62. Robinson SE, Nagarajan SS, Mantle M, Gibbons V, Kirsch H. Localization of interictal spikes using SAM(g2) and dipole fit. Neurol Clin Neurophysiol. 2004; 2004:74. PMID: 16012648; PMCID: PMC4041981.
      63. Kirsch HE, Sepkuty JP, Crone NE. Multimodal functional mapping of sensorimotor cortex prior to resection of an epileptogenic perirolandic lesion. Epilepsy Behav. 2004 Jun; 5(3):407-10. PMID: 15145312.
        View in: PubMed
      64. Kirsch HE. The utility of a federated web-based information management system in an epilepsy center. Neuroinformatics. 2004; 2(1):119-21. PMID: 15067171.
        View in: PubMed
      Heidi's Networks
      Related Concepts
      Derived automatically from this person's publications.
      People in Profiles who have published with this person.
      Related Authors
      People who share related concepts with this person.
      Back to TOP