Wilson Liao, MD
|School||UCSF School of Medicine|
|Address||2340 Sutter Street|
San Francisco CA 94143
|Harvard University||A.B.||Biochemical Sciences||1998|
|National Institutes of Health||Clinical Research Training Fellowship||National Human Genome Research Institute||2002|
|Harvard University||M.D.||School of Medicine||2003|
|University of California San Francisco||Clinical Residency||Department of Dermatology||2007|
|University of California San Francisco||Postdoctoral Fellowship||Human Genetics||2009|
Our laboratory studies the genetics and environmental triggers of psoriasis, a common autoimmune skin disease. We have initiated a psoriasis research cohort and biobank at UCSF with over 900 subjects, which is used for genetic and translational research studies. Our lab has contributed to the publication of the first two genome-wide association studies in psoriasis and has helped identify over 20 additional risk variants, including a deletion of the late cornified envelope genes, common variants in UBE2L3 and SH2B3, copy number changes in KIR3DS1 and NKG2C, and rare variants in IFIH1 and CARD14. Our lab has identified a genetic similarity between individuals with psoriasis and individuals who have robust immunity against HIV-1. This has highlighted the role of antiviral immune responses in contributing to autoimmune susceptibility. Current projects include the identification of causal variants in psoriasis through a combination of functional genomics and next generation sequencing, investigating the role of non-coding RNAs in psoriasis, and determining the role of the microbiome in psoriatic inflammation. We welcome inquiries about collaborations and student participation in research.
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