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    Wilson Liao, MD

    TitleAssociate Professor
    SchoolUCSF School of Medicine
    DepartmentDermatology
    Address2340 Sutter Street
    San Francisco CA 94143
    Phone415-476-8364

       Overview 
       Overview
      EDUCATION/TRAINING
      B.A. in Biochemical Sciences, Harvard University, 1998
      Clinical Research Training Program, National Institutes of Health, 2002
      M.D., Harvard Medical School, 2003
      Residency in Dermatology: University of California, San Francisco, 2007

      ACADEMIC INTERESTS
      Our laboratory studies the genetics and environmental triggers of psoriasis, a common autoimmune skin disease. We have initiated a psoriasis research cohort and biobank at UCSF with over 900 subjects, which is used for genetic and translational research studies. Our lab has contributed to the publication of the first two genome-wide association studies in psoriasis and has helped identify over 20 additional risk variants, including a deletion of the late cornified envelope genes, common variants in UBE2L3 and SH2B3, copy number changes in KIR3DS1 and NKG2C, and rare variants in IFIH1 and CARD14. Our lab has identified a genetic similarity between individuals with psoriasis and individuals who have robust immunity against HIV-1. This has highlighted the role of antiviral immune responses in contributing to autoimmune susceptibility. Current projects include the identification of causal variants in psoriasis through a combination of functional genomics and next generation sequencing, investigating the role of non-coding RNAs in psoriasis, and determining the role of the microbiome in psoriatic inflammation. We welcome inquiries about collaborations and student participation in research.


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       Global Health
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       Bibliographic 
       Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Bhatia BK, Millsop JW, Debbaneh M, Koo J, Linos E, Liao W. Diet and psoriasis, part II: Celiac disease and role of a gluten-free diet. J Am Acad Dermatol. 2014 Apr 26.
        View in: PubMed
      2. Millsop JW, Bhatia BK, Debbaneh M, Koo J, Liao W. Diet and psoriasis, part III: Role of nutritional supplements. J Am Acad Dermatol. 2014 Apr 25.
        View in: PubMed
      3. Debbaneh M, Millsop JW, Bhatia BK, Koo J, Liao W. Diet and psoriasis, part I: Impact of weight loss interventions. J Am Acad Dermatol. 2014 Apr 4.
        View in: PubMed
      4. Levin EC, Debbaneh M, Koo J, Liao W. Biologic therapy in erythrodermic and pustular psoriasis. J Drugs Dermatol. 2014 Mar 1; 13(3):342-54.
        View in: PubMed
      5. Gupta R, Debbaneh MG, Liao W. Genetic Epidemiology of Psoriasis. Current Dermatology Reports. 2014; 3(1):61-78.
      6. Sanchez Rodriguez R, Pauli ML, Neuhaus IM, Yu SS, Arron ST, Harris HW, Yang SH, Anthony BA, Sverdrup FM, Krow-Lucal E, Mackenzie TC, Johnson DS, Meyer EH, Löhr A, Hsu A, Koo J, Liao W, Gupta R, Debbaneh MG, Butler D, Huynh M, Levin EC, Leon A, Hoffman WY, McGrath MH, Alvarado MD, Ludwig CH, Truong HA, Maurano MM, Gratz IK, Abbas AK, Rosenblum MD. Memory regulatory T cells reside in human skin. J Clin Invest. 2014 Mar 3; 124(3):1027-36.
        View in: PubMed
      7. Dimon MT, Wood HM, Rabbitts PH, Liao W, Cho RJ, Arron ST. No Evidence for Integrated Viral DNA in the Genome Sequence of Cutaneous Squamous Cell Carcinoma. J Invest Dermatol. 2014 Jan 30.
        View in: PubMed
      8. Wu W, Debbaneh M, Moslehi H, Koo J, Liao W. Tonsillectomy as a treatment for psoriasis: A review. J Dermatolog Treat. 2014 Dec; 25(6):482-6.
        View in: PubMed
      9. Kulkarni S, Qi Y, O'huigin C, Pereyra F, Ramsuran V, McLaren P, Fellay J, Nelson G, Chen H, Liao W, Bass S, Apps R, Gao X, Yuki Y, Lied A, Ganesan A, Hunt PW, Deeks SG, Wolinsky S, Walker BD, Carrington M. Genetic interplay between HLA-C and MIR148A in HIV control and Crohn disease. Proc Natl Acad Sci U S A. 2013 Dec 17; 110(51):20705-10.
        View in: PubMed
      10. Gupta R, Wu JJ, Levin E, Koo JY, Liao W. Possible drug-drug interaction between adalimumab and duloxetine and/or pregabalin in a psoriasis patient. J Drugs Dermatol. 2013 Oct; 12(10):1089.
        View in: PubMed
      11. Zeng X, Chen H, Gupta R, Paz-Altschul O, Bowcock AM, Liao W. Deletion of the activating NKG2C receptor and a functional polymorphism in its ligand HLA-E in psoriasis susceptibility. Exp Dermatol. 2013 Oct; 22(10):679-81.
        View in: PubMed
      12. Lu Y, Kane S, Chen H, Leon A, Levin E, Nguyen T, Debbaneh M, Millsop JW, Gupta R, Huynh M, Butler D, Cordoro K, Liao W. The role of 39 psoriasis risk variants on age of psoriasis onset. ISRN Dermatol. 2013; 2013:203941.
        View in: PubMed
      13. Gupta R, Levin E, Wu JJ, Koo J, Liao W. An update on drug-drug interactions with biologics for the treatment of moderate-to-severe psoriasis. J Dermatolog Treat. 2014 Feb; 25(1):87-9.
        View in: PubMed
      14. Raposo RA, Abdel-Mohsen M, Holditch SJ, Kuebler PJ, Cheng RG, Eriksson EM, Liao W, Pillai SK, Nixon DF. Increased expression of intrinsic antiviral genes in HLA-B*57-positive individuals. J Leukoc Biol. 2013 Nov; 94(5):1051-9.
        View in: PubMed
      15. Gupta R, Debbaneh M, Butler D, Huynh M, Levin E, Leon A, Koo J, Liao W. The Goeckerman regimen for the treatment of moderate to severe psoriasis. J Vis Exp. 2013; (77):e50509.
        View in: PubMed
      16. Emson CL, Fitzmaurice S, Lindwall G, Li KW, Hellerstein MK, Maibach HI, Liao W, Turner SM. A pilot study demonstrating a non-invasive method for the measurement of protein turnover in skin disorders: application to psoriasis. Clin Transl Med. 2013; 2:12.
        View in: PubMed
      17. Apps R, Qi Y, Carlson JM, Chen H, Gao X, Thomas R, Yuki Y, Del Prete GQ, Goulder P, Brumme ZL, Brumme CJ, John M, Mallal S, Nelson G, Bosch R, Heckerman D, Stein JL, Soderberg KA, Moody MA, Denny TN, Zeng X, Fang J, Moffett A, Lifson JD, Goedert JJ, Buchbinder S, Kirk GD, Fellay J, McLaren P, Deeks SG, Pereyra F, Walker B, Michael NL, Weintrob A, Wolinsky S, Liao W, Carrington M. Influence of HLA-C expression level on HIV control. Science. 2013 Apr 5; 340(6128):87-91.
        View in: PubMed
      18. Batista MD, Tincati C, Milush JM, Ho EL, Ndhlovu LC, York VA, Kallas EG, Kalil J, Keating SM, Norris PJ, Chang D, Unemori P, Leslie KS, Maurer T, Liao W, Nixon DF. CD57 expression and cytokine production by T cells in lesional and unaffected skin from patients with psoriasis. PLoS One. 2013; 8(2):e52144.
        View in: PubMed
      19. Leon A, Liao WJ, Gupta R, Koo JYM, Wu JJ. Tumor Necrosis Factor-Alpha Triad: Psoriasis, Cardiovascular Disease, and Depression. Psoriasis Forum. 2013; 19(1):41-49.
      20. Wong T, Hsu L, Liao W. Phototherapy in psoriasis: a review of mechanisms of action. J Cutan Med Surg. 2013 Jan-Feb; 17(1):6-12.
        View in: PubMed
      21. Batista MD, Ho EL, Kuebler PJ, Milush JM, Lanier LL, Kallas EG, York VA, Chang D, Liao W, Unemori P, Leslie KS, Maurer T, Nixon DF. Skewed distribution of natural killer cells in psoriasis skin lesions. Exp Dermatol. 2013 Jan; 22(1):64-6.
        View in: PubMed
      22. Lu Y, Chen H, Nikamo P, Qi Low H, Helms C, Seielstad M, Liu J, Bowcock AM, Stahle M, Liao W. Association of cardiovascular and metabolic disease genes with psoriasis. J Invest Dermatol. 2013 Mar; 133(3):836-9.
        View in: PubMed
      23. Park KK, Liao W, Murase JE. A review of monochromatic excimer light in vitiligo. Br J Dermatol. 2012 Sep; 167(3):468-78.
        View in: PubMed
      24. Su SY, Kasberger J, Baranzini S, Byerley W, Liao W, Oksenberg J, Sherr E, Jorgenson E. Detection of identity by descent using next-generation whole genome sequencing data. BMC Bioinformatics. 2012; 13:121.
        View in: PubMed
      25. Jordan CT, Cao L, Roberson ED, Duan S, Helms CA, Nair RP, Duffin KC, Stuart PE, Goldgar D, Hayashi G, Olfson EH, Feng BJ, Pullinger CR, Kane JP, Wise CA, Goldbach-Mansky R, Lowes MA, Peddle L, Chandran V, Liao W, Rahman P, Krueger GG, Gladman D, Elder JT, Menter A, Bowcock AM. Rare and common variants in CARD14, encoding an epidermal regulator of NF-kappaB, in psoriasis. Am J Hum Genet. 2012 May 4; 90(5):796-808.
        View in: PubMed
      26. Lai OY, Chen H, Michaud HA, Hayashi G, Kuebler PJ, Hultman GK, Ariza ME, Williams MV, Batista MD, Nixon DF, Foerster J, Bowcock AM, Liao W. Protective effect of human endogenous retrovirus K dUTPase variants on psoriasis susceptibility. J Invest Dermatol. 2012 Jul; 132(7):1833-40.
        View in: PubMed
      27. Chen H, Hayashi G, Lai OY, Dilthey A, Kuebler PJ, Wong TV, Martin MP, Fernandez Vina MA, McVean G, Wabl M, Leslie KS, Maurer T, Martin JN, Deeks SG, Carrington M, Bowcock AM, Nixon DF, Liao W. Psoriasis patients are enriched for genetic variants that protect against HIV-1 disease. PLoS Genet. 2012 Feb; 8(2):e1002514.
        View in: PubMed
      28. Birnbaum RY, Hayashi G, Cohen I, Poon A, Chen H, Lam ET, Kwok PY, Birk OS, Liao W. Association analysis identifies ZNF750 regulatory variants in psoriasis. BMC Med Genet. 2011; 12:167.
        View in: PubMed
      29. Kamangar F, Isip L, Bhutani T, Dennis M, Heller MM, Lee ES, Nie H, Liao W. How psoriasis patients perceive, obtain, and use biologic agents: Survey from an academic medical center. J Dermatolog Treat. 2013 Feb; 24(1):13-24.
        View in: PubMed
      30. Roberson ED, Liu Y, Ryan C, Joyce CE, Duan S, Cao L, Martin A, Liao W, Menter A, Bowcock AM. A subset of methylated CpG sites differentiate psoriatic from normal skin. J Invest Dermatol. 2012 Mar; 132(3 Pt 1):583-92.
        View in: PubMed
      31. Wang NJ, Sanborn Z, Arnett KL, Bayston LJ, Liao W, Proby CM, Leigh IM, Collisson EA, Gordon PB, Jakkula L, Pennypacker S, Zou Y, Sharma M, North JP, Vemula SS, Mauro TM, Neuhaus IM, Leboit PE, Hur JS, Park K, Huh N, Kwok PY, Arron ST, Massion PP, Bale AE, Haussler D, Cleaver JE, Gray JW, Spellman PT, South AP, Aster JC, Blacklow SC, Cho RJ. Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma. Proc Natl Acad Sci U S A. 2011 Oct 25; 108(43):17761-6.
        View in: PubMed
      32. Dennis M, Bhutani T, Koo J, Liao W. Goeckerman therapy for the treatment of eczema: a practical guide and review of efficacy. J Dermatolog Treat. 2013 Feb; 24(1):2-6.
        View in: PubMed
      33. Durinck S, Ho C, Wang NJ, Liao W, Jakkula LR, Collisson EA, Pons J, Chan SW, Lam ET, Chu C, Park K, Hong SW, Hur JS, Huh N, Neuhaus IM, Yu SS, Grekin RC, Mauro TM, Cleaver JE, Kwok PY, LeBoit PE, Getz G, Cibulskis K, Aster JC, Huang H, Purdom E, Li J, Bolund L, Arron ST, Gray JW, Spellman PT, Cho RJ. Temporal dissection of tumorigenesis in primary cancers. Cancer Discov. 2011 Jul; 1(2):137-43.
        View in: PubMed
      34. Chen H, Poon A, Yeung C, Helms C, Pons J, Bowcock AM, Kwok PY, Liao W. A genetic risk score combining ten psoriasis risk loci improves disease prediction. PLoS One. 2011; 6(4):e19454.
        View in: PubMed
      35. Musone SL, Taylor KE, Nititham J, Chu C, Poon A, Liao W, Lam ET, Ma A, Kwok PY, Criswell LA. Sequencing of TNFAIP3 and association of variants with multiple autoimmune diseases. Genes Immun. 2011 Apr; 12(3):176-82.
        View in: PubMed
      36. Lee ES, Heller MM, Kamangar F, Park K, Liao W, Koo J. Hydroxyurea for the Treatment of Psoriasis with an Emphasis on HIV-Infected Psoriasis Patients: A Review. Psoriasis Forum. 2011; 3(17):180-187.
      37. Riveira-Munoz E, He SM, Escaramís G, Stuart PE, Hüffmeier U, Lee C, Kirby B, Oka A, Giardina E, Liao W, Bergboer J, Kainu K, de Cid R, Munkhbat B, Zeeuwen PL, Armour JA, Poon A, Mabuchi T, Ozawa A, Zawirska A, Burden AD, Barker JN, Capon F, Traupe H, Sun LD, Cui Y, Yin XY, Chen G, Lim HW, Nair RP, Voorhees JJ, Tejasvi T, Pujol R, Munkhtuvshin N, Fischer J, Kere J, Schalkwijk J, Bowcock A, Kwok PY, Novelli G, Inoko H, Ryan AW, Trembath RC, Reis A, Zhang XJ, Elder JT, Estivill X. Meta-analysis confirms the LCE3C_LCE3B deletion as a risk factor for psoriasis in several ethnic groups and finds interaction with HLA-Cw6. J Invest Dermatol. 2011 May; 131(5):1105-9.
        View in: PubMed
      38. Li Y, Liao W, Cargill M, Chang M, Matsunami N, Feng BJ, Poon A, Callis-Duffin KP, Catanese JJ, Bowcock AM, Leppert MF, Kwok PY, Krueger GG, Begovich AB. Carriers of rare missense variants in IFIH1 are protected from psoriasis. J Invest Dermatol. 2010 Dec; 130(12):2768-72.
        View in: PubMed
      39. Kamaria M, Liao W, Koo J. A Practical Approach to the Use of Cyclosporine for the Treatment of Psoriasis. Psoriasis Forum. 2010; 1(16):49-58.
      40. Kamaria M, Liao W, Koo JY. How Long Does the Benefit of Biologics Last? An Update on Time to Relapse and Potential for Rebound of Biologic Agents for Psoriasis. Psoriasis Forum. 2010; 2(16):36-42.
      41. Bhutani T, Liao W. Practical Approach to Home UVB Phototherapy for the Treatment of Generalized Psoriasis. Practical Dermatology. 2010; (August):31-35.
      42. Busse K, Liao W. Which Psoriasis Patients Develop Psoriatic Arthritis?. Psoriasis Forum. 2010; 4(16):17-25.
      43. Wan E, Akana M, Pons J, Chen J, Musone S, Kwok PY, Liao W. Green technologies for room temperature nucleic acid storage. Curr Issues Mol Biol. 2010; 12(3):135-42.
        View in: PubMed
      44. Nair RP, Duffin KC, Helms C, Ding J, Stuart PE, Goldgar D, Gudjonsson JE, Li Y, Tejasvi T, Feng BJ, Ruether A, Schreiber S, Weichenthal M, Gladman D, Rahman P, Schrodi SJ, Prahalad S, Guthery SL, Fischer J, Liao W, Kwok PY, Menter A, Lathrop GM, Wise CA, Begovich AB, Voorhees JJ, Elder JT, Krueger GG, Bowcock AM, Abecasis GR. Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways. Nat Genet. 2009 Feb; 41(2):199-204.
        View in: PubMed
      45. de Cid R, Riveira-Munoz E, Zeeuwen PL, Robarge J, Liao W, Dannhauser EN, Giardina E, Stuart PE, Nair R, Helms C, Escaramís G, Ballana E, Martín-Ezquerra G, den Heijer M, Kamsteeg M, Joosten I, Eichler EE, Lázaro C, Pujol RM, Armengol L, Abecasis G, Elder JT, Novelli G, Armour JA, Kwok PY, Bowcock A, Schalkwijk J, Estivill X. Deletion of the late cornified envelope LCE3B and LCE3C genes as a susceptibility factor for psoriasis. Nat Genet. 2009 Feb; 41(2):211-5.
        View in: PubMed
      46. Li Y, Liao W, Chang M, Schrodi SJ, Bui N, Catanese JJ, Poon A, Matsunami N, Callis-Duffin KP, Leppert MF, Bowcock AM, Kwok PY, Krueger GG, Begovich AB. Further genetic evidence for three psoriasis-risk genes: ADAM33, CDKAL1, and PTPN22. J Invest Dermatol. 2009 Mar; 129(3):629-34.
        View in: PubMed
      47. Liu Y, Helms C, Liao W, Zaba LC, Duan S, Gardner J, Wise C, Miner A, Malloy MJ, Pullinger CR, Kane JP, Saccone S, Worthington J, Bruce I, Kwok PY, Menter A, Krueger J, Barton A, Saccone NL, Bowcock AM. A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci. PLoS Genet. 2008 Mar; 4(3):e1000041.
        View in: PubMed
      48. Arron ST, Liao W, Maurer T. Scurvy: a presenting sign of psychosis. J Am Acad Dermatol. 2007 Aug; 57(2 Suppl):S8-10.
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      49. Wongsrichanalai C, Murray CK, Gray M, Miller RS, McDaniel P, Liao WJ, Pickard AL, Magill AJ. Co-infection with malaria and leptospirosis. Am J Trop Med Hyg. 2003 May; 68(5):583-5.
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