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Anna Victoria Molofsky, MD, PhD

TitleAssistant Professor
SchoolUCSF School of Medicine
DepartmentPsychiatry
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    Collapse Biography 
    Collapse Education and Training
    Amherst CollegeB.A.
    University of MichiganM.D.
    University of MichiganPh.D
    University of California-San FranciscoAdult Psychiatry Residency
    Collapse Awards and Honors
    1997Phi Beta Kappa
    2006Harold M. Weintraub Graduate Student Award
    2015Burroughs Wellcome Career Award for Medical Scientists
    2017 Pew Biomedical Scholar
    2017NIH New Innovator Award

    Collapse Research 
    Collapse Research Activities and Funding
    Coordinate regulation of neural circuit remodeling by glia: a prospective molecular approach
    NIH/NIMH DP2MH116507Sep 1, 2017 - May 31, 2022
    Role: Principal Investigator
    Region-restricted astrocytes in neural circuit formation and function
    NIH/NIMH K08MH104417Jul 25, 2014 - Jun 30, 2018
    Role: Principal Investigator
    The role of the oncogene Bmi-1 in fibrobrain development
    NIH/NINDS F30NS048642Mar 1, 2004 - Feb 28, 2007
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Kelley KW, Ben Haim L, Schirmer L, Tyzack GE, Tolman M, Miller JG, Tsai HH, Chang SM, Molofsky A, Yang Y, Patani R, Lakatos A, Ullian EM, Rowitch DH. Kir4.1-Dependent Astrocyte-Fast Motor Neuron Interactions Are Required for Peak Strength. Neuron. 2018 Mar 28. PMID: 29606582.
      View in: PubMed
    2. Vainchtein ID, Chin G, Cho FS, Kelley KW, Miller JG, Chien EC, Liddelow SA, Nguyen PT, Nakao-Inoue H, Dorman LC, Akil O, Joshita S, Barres BA, Paz JT, Molofsky AB, Molofsky A. Astrocyte-derived interleukin-33 promotes microglial synapse engulfment and neural circuit development. Science. 2018 03 16; 359(6381):1269-1273. PMID: 29420261.
      View in: PubMed
    3. Poskanzer KE, Molofsky A. Dynamism of an Astrocyte In Vivo: Perspectives on Identity and Function. Annu Rev Physiol. 2018 Feb 10; 80:143-157. PMID: 29166242.
      View in: PubMed
    4. Molofsky AV, Deneen B. Astrocyte development: A Guide for the Perplexed. Glia. 2015 Aug; 63(8):1320-9. PMID: 25963996.
      View in: PubMed
    5. Molofsky AV, Kelley KW, Tsai HH, Redmond SA, Chang SM, Madireddy L, Chan JR, Baranzini SE, Ullian EM, Rowitch DH. Astrocyte-encoded positional cues maintain sensorimotor circuit integrity. Nature. 2014 May 08; 509(7499):189-94. PMID: 24776795; PMCID: PMC4057936.
    6. Molofsky AV, Glasgow SM, Chaboub LS, Tsai HH, Murnen AT, Kelley KW, Fancy SP, Yuen TJ, Madireddy L, Baranzini S, Deneen B, Rowitch DH, Oldham MC. Expression profiling of Aldh1l1-precursors in the developing spinal cord reveals glial lineage-specific genes and direct Sox9-Nfe2l1 interactions. Glia. 2013 Sep; 61(9):1518-32. PMID: 23840004; PMCID: PMC3909648.
    7. Tsai HH, Li H, Fuentealba LC, Molofsky AV, Taveira-Marques R, Zhuang H, Tenney A, Murnen AT, Fancy SP, Merkle F, Kessaris N, Alvarez-Buylla A, Richardson WD, Rowitch DH. Regional astrocyte allocation regulates CNS synaptogenesis and repair. Science. 2012 Jul 20; 337(6092):358-62. PMID: 22745251; PMCID: PMC4059181.
    8. Tien AC, Tsai HH, Molofsky AV, McMahon M, Foo LC, Kaul A, Dougherty JD, Heintz N, Gutmann DH, Barres BA, Rowitch DH. Regulated temporal-spatial astrocyte precursor cell proliferation involves BRAF signalling in mammalian spinal cord. Development. 2012 Jul; 139(14):2477-87. PMID: 22675209; PMCID: PMC3383225.
    9. Molofsky AV, Krencik R, Krenick R, Ullian EM, Ullian E, Tsai HH, Deneen B, Richardson WD, Barres BA, Rowitch DH. Astrocytes and disease: a neurodevelopmental perspective. Genes Dev. 2012 May 01; 26(9):891-907. PMID: 22549954; PMCID: PMC3347787.
    10. He S, Iwashita T, Buchstaller J, Molofsky AV, Thomas D, Morrison SJ. Bmi-1 over-expression in neural stem/progenitor cells increases proliferation and neurogenesis in culture but has little effect on these functions in vivo. Dev Biol. 2009 Apr 15; 328(2):257-72. PMID: 19389366; PMCID: PMC2996717.
    11. Molofsky AV, Slutsky SG, Joseph NM, He S, Pardal R, Krishnamurthy J, Sharpless NE, Morrison SJ. Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing. Nature. 2006 Sep 28; 443(7110):448-52. PMID: 16957738; PMCID: PMC2586960.
    12. Molofsky AV, He S, Bydon M, Morrison SJ, Pardal R. Bmi-1 promotes neural stem cell self-renewal and neural development but not mouse growth and survival by repressing the p16Ink4a and p19Arf senescence pathways. Genes Dev. 2005 Jun 15; 19(12):1432-7. PMID: 15964994; PMCID: PMC1151659.
    13. Pardal R, Molofsky AV, He S, Morrison SJ. Stem cell self-renewal and cancer cell proliferation are regulated by common networks that balance the activation of proto-oncogenes and tumor suppressors. Cold Spring Harb Symp Quant Biol. 2005; 70:177-85. PMID: 16869752.
      View in: PubMed
    14. Molofsky AV, Pardal R, Morrison SJ. Diverse mechanisms regulate stem cell self-renewal. Curr Opin Cell Biol. 2004 Dec; 16(6):700-7. PMID: 15530784.
      View in: PubMed
    15. Molofsky AV, Pardal R, Iwashita T, Park IK, Clarke MF, Morrison SJ. Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation. Nature. 2003 Oct 30; 425(6961):962-7. PMID: 14574365; PMCID: PMC2614897.
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