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    Daniel Cooke, MD

    TitleAssistant Professor
    SchoolUCSF School of Medicine
    DepartmentRadiology
    Address505 Parnassus Avenue
    San Francisco CA 94117
    Phone415-206-6607
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      Collapse Biography 
      Collapse Education and Training
      University of California, San FranciscoClinical Fellowship Radiology
      Collapse Awards and Honors
      University of Washington2009Neuroradiology Research Award
      ACR Reeder2008Goldberg International Grant

      Collapse Overview 
      Collapse Overview
      Daniel Cooke, MD, is an Assistant Professor in Residence of Neuro Interventional Radiology in the Department of Radiology and Biomedical Imaging at the University of California, San Francisco. His expertise is in ischemic and hemorrhagic stroke, vascular malignancies of the central nervous system, arteriovenous malformations (AVM), arteriovenous fistula (AVF), and aneurysms of the brain and spine. Dr. Cooke earned his medical degree from Emory University, Atlanta in 2004, and completed his residency in Diagnostic Radiology at the University of Washington, Seattle. He completed a fellowship in Neuroradiology at the University of Washington, Seattle in 2010, followed by another fellowship in Neuro Interventional Radiology from the University of California, San Francisco in 2012.

      Dr. Cooke’s primary research is in the use of contemporary endovascular surgical methods to assess endothelial cells in the setting of neurovascular pathology. In his work with MR generated computational fluid dynamic data and microsurgical specimens he aims to characterize the local and regional molecular events underlying the evolution of aneurysms, AVMs, and AVFs.

      Dr. Cooke’s research interests include: endovascular biopsy, pre-natal brain AVM detection, endovascular brachytherapy, flat panel CT-fluoroscopically guided intervention, and chemoinfusion. Dr. Cooke is also involved in research on catheter-based interventions for hemorrhagic stroke as well as regenerative cell therapies for ischemic stroke.

      Expertise:
      Neuro Interventional Radiology

      Specialty:
      Ischemic and hemorrhagic stroke, vascular malignancies of the central nervous system, and arteriovenous malformations (AVM), arteriovenous fistula (AVF), and aneurysms of the brain and spine

      Professional Interests:
      Stroke, arteriovenous malformation, arteriovenous fistula, aneurysm, cerebral vascular disease, endothelium, intracerebral hemorrhage, spinal vascular anomalies, vascular cerebral, spinal, and head and neck malignancy, retinoblastoma, high and low flow vascular malformations

      Education and Training:
      • Medical School: Emory University, Atlanta, Georgia
      • Internship: University of Hawaii, Honolulu - Surgery
      • Residency: University of Washington, Seattle - Radiology
      • Fellowship: University of Washington, Seattle - Neuroradiology
      • Fellowship: University of California, San Francisco - Neuro Interventional
      • Medical licensure, California
      • American Board of Radiology with sub-specialty certification in Neuroradiology

      Collapse Interests
      Stroke, arteriovenous malformation, arteriovenous fistula, aneurysm, cerebral vascular disease, endothelium, intracerebral hemorrhage, spinal vascular anomalies, vascular cerebral, spinal, and head and neck malignancy, retinoblastoma, high and low flow vascular malformations.

      Collapse ORNG Applications 
      Collapse Clinical Trials

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Lum MA, Martin AJ, Alexander MD, McCoy DB, Cooke DL, Lillaney P, Moftakhar P, Amans MR, Settecase F, Nicholson A, Dowd CF, Halbach VV, Higashida RT, McDermott MW, Saloner D, Hetts SW. Intra-Arterial MR Perfusion Imaging of Meningiomas: Comparison to Digital Subtraction Angiography and Intravenous MR Perfusion Imaging. PLoS One. 2016; 11(11):e0163554. PMID: 27802268.
        View in: PubMed
      2. Alexander MD, Nicholson AD, Darflinger RJ, Settecase F, Cooke DL, Dowd CF, Amans MR, Higashida RT, Hetts SW, Halbach VV. Effects on vessel measurement accuracy and subsequent occlusion after calcium channel blocker infusion during treatment of cerebral aneurysms with the Pipeline embolization device. Interv Neuroradiol. 2016 Oct 26. PMID: 27798327.
        View in: PubMed
      3. Hetts SW, Moftakhar P, Maluste N, Fullerton HJ, Cooke DL, Amans MR, Dowd CF, Higashida RT, Halbach VV. Pediatric intracranial dural arteriovenous fistulas: age-related differences in clinical features, angioarchitecture, and treatment outcomes. J Neurosurg Pediatr. 2016 Nov; 18(5):602-610. PMID: 27540826.
        View in: PubMed
      4. Alexander MD, Cooke DL, Hallam DK, Kim H, Hetts SW, Ghodke BV. Less can be more: Targeted embolization of aneurysms associated with arteriovenous malformations unsuitable for surgical resection. Interv Neuroradiol. 2016 Aug; 22(4):445-51. PMID: 27066813.
        View in: PubMed
      5. Lillaney PV, Yang JK, Losey AD, Martin AJ, Cooke DL, Thorne BR, Barry DC, Chu A, Stillson C, Do L, Arenson RL, Saeed M, Wilson MW, Hetts SW. Endovascular MR-guided Renal Embolization by Using a Magnetically Assisted Remote-controlled Catheter System. Radiology. 2016 Oct; 281(1):219-28. PMID: 27019290.
        View in: PubMed
      6. Mabray MC, Lillaney P, Sze CH, Losey AD, Yang J, Kondapavulur S, Liu D, Saeed M, Patel A, Cooke D, Jun YW, El-Sayed I, Wilson M, Hetts SW. In Vitro Capture of Small Ferrous Particles with a Magnetic Filtration Device Designed for Intravascular Use with Intraarterial Chemotherapy: Proof-of-Concept Study. J Vasc Interv Radiol. 2016 Mar; 27(3):426-432.e1. PMID: 26706187.
        View in: PubMed
      7. Settecase F, Nicholson AD, Amans MR, Higashida RT, Halbach VV, Cooke DL, Dowd CF, Hetts SW. Onyx embolization of an intraosseous pseudoaneurysm of the middle meningeal artery in a patient with meningiomatosis, McCune-Albright syndrome, and gray platelet syndrome. J Neurosurg Pediatr. 2016 Mar; 17(3):324-9. PMID: 26588455.
        View in: PubMed
      8. Settecase F, Hetts SW, Nicholson AD, Amans MR, Cooke DL, Dowd CF, Higashida RT, Halbach VV. Superselective Intra-Arterial Ethanol Sclerotherapy of Feeding Artery and Nidal Aneurysms in Ruptured Cerebral Arteriovenous Malformations. AJNR Am J Neuroradiol. 2016 Apr; 37(4):692-7. PMID: 26564434.
        View in: PubMed
      9. Narvid J, Amans MR, Cooke DL, Hetts SW, Dillon WP, Higashida RT, Dowd CF, Halbach VV. Spontaneous retroclival hematoma: a case series. J Neurosurg. 2016 Mar; 124(3):716-9. PMID: 26252463.
        View in: PubMed
      10. Cooke DL, Levitt MR, Kim LJ, Hallam DK, Sekhar LN, Ghodke BV. Laser-assisted flat-detector CT-guided intracranial access. Int J Comput Assist Radiol Surg. 2016 Mar; 11(3):467-72. PMID: 26239371.
        View in: PubMed
      11. Sun Z, Lawson DA, Sinclair E, Wang CY, Lai MD, Hetts SW, Higashida RT, Dowd CF, Halbach VV, Werb Z, Su H, Cooke DL. Endovascular biopsy: Strategy for analyzing gene expression profiles of individual endothelial cells obtained from human vessels(?). Biotechnol Rep (Amst). 2015 Sep; 7:157-165. PMID: 26989654.
        View in: PubMed
      12. Hetts SW, Tsai T, Cooke DL, Amans MR, Settecase F, Moftakhar P, Dowd CF, Higashida RT, Lawton MT, Halbach VV. Progressive versus Nonprogressive Intracranial Dural Arteriovenous Fistulas: Characteristics and Outcomes. AJNR Am J Neuroradiol. 2015 Oct; 36(10):1912-9. PMID: 26206813.
        View in: PubMed
      13. Mabray MC, Datta S, Lillaney PV, Moore T, Gehrisch S, Talbott JF, Levitt MR, Ghodke BV, Larson PS, Cooke DL. Accuracy of flat panel detector CT with integrated navigational software with and without MR fusion for single-pass needle placement. J Neurointerv Surg. 2016 Jul; 8(7):731-5. PMID: 26047903.
        View in: PubMed
      14. Moftakhar P, Lillaney P, Losey AD, Cooke DL, Martin AJ, Thorne BR, Arenson RL, Saeed M, Wilson MW, Hetts SW. New-Generation Laser-lithographed Dual-Axis Magnetically Assisted Remote-controlled Endovascular Catheter for Interventional MR Imaging: In Vitro Multiplanar Navigation at 1.5 T and 3 T versus X-ray Fluoroscopy. Radiology. 2015 Dec; 277(3):842-52. PMID: 26030659.
        View in: PubMed
      15. Alexander MD, Rebhun JM, Hetts SW, Kim AS, Nelson J, Kim H, Amans MR, Settecase F, Dowd CF, Halbach VV, Higashida RT, Cooke DL. Lesion location, stability, and pretreatment management: factors affecting outcomes of endovascular treatment for vertebrobasilar atherosclerosis. J Neurointerv Surg. 2016 May; 8(5):466-70. PMID: 25795438.
        View in: PubMed
      16. Moftakhar P, Cooke DL, Fullerton HJ, Ko NU, Amans MR, Narvid JA, Dowd CF, Higashida RT, Halbach VV, Hetts SW. Extent of collateralization predicting symptomatic cerebral vasospasm among pediatric patients: correlations among angiography, transcranial Doppler ultrasonography, and clinical findings. J Neurosurg Pediatr. 2015 Mar; 15(3):282-90. PMID: 25555113.
        View in: PubMed
      17. Sun Z, Su H, Long B, Sinclair E, Hetts SW, Higashida RT, Dowd CF, Halbach VV, Cooke DL. Endothelial cell high-enrichment from endovascular biopsy sample by laser capture microdissection and fluorescence activated cell sorting. J Biotechnol. 2014 Dec 20; 192 Pt A:34-9. PMID: 25450638.
        View in: PubMed
      18. Alexander MD, Cooke DL, Meyers PM, Amans MR, Dowd CF, Halbach VV, Higashida RT, Hetts SW. Lesion stability characteristics outperform degree of stenosis in predicting outcomes following stenting for symptomatic intracranial atherosclerosis. J Neurointerv Surg. 2016 Jan; 8(1):19-23. PMID: 25416828.
        View in: PubMed
      19. Raygor KP, Rowland NC, Cooke DL, Solomon DA, Huang MC. Aneurysm of the posterior meningeal artery embedded within a dorsal exophytic medullary hemangioblastoma: surgical management and review of literature. J Cerebrovasc Endovasc Neurosurg. 2014 Sep; 16(3):293-8. PMID: 25340034; PMCID: PMC4205258.
      20. Cooke DL, Stout CE, Kim WT, Kansagra AP, Yu JP, Gu A, Jewell NP, Hetts SW, Higashida RT, Dowd CF, Halbach VV. Cerebral arterial fenestrations. Interv Neuroradiol. 2014 May-Jun; 20(3):261-74. PMID: 24976087; PMCID: PMC4178766.
      21. Chow ML, Cooke DL, Fullerton HJ, Amans MR, Narvid J, Dowd CF, Higashida RT, Halbach VV, Hetts SW. Radiological and clinical features of vein of Galen malformations. J Neurointerv Surg. 2015 Jun; 7(6):443-8. PMID: 24789593.
        View in: PubMed
      22. Alexander MD, Meyers PM, English JD, Stradford TR, Sung S, Smith WS, Halbach VV, Higashida RT, Dowd CF, Cooke DL, Hetts SW. Symptom differences and pretreatment asymptomatic interval affect outcomes of stenting for intracranial atherosclerotic disease. AJNR Am J Neuroradiol. 2014 Jun; 35(6):1157-62. PMID: 24676000.
        View in: PubMed
      23. Hetts SW, Cooke DL, Nelson J, Gupta N, Fullerton H, Amans MR, Narvid JA, Moftakhar P, McSwain H, Dowd CF, Higashida RT, Halbach VV, Lawton MT, Kim H. Influence of patient age on angioarchitecture of brain arteriovenous malformations. AJNR Am J Neuroradiol. 2014 Jul; 35(7):1376-80. PMID: 24627452; PMCID: PMC4102659.
      24. Losey AD, Lillaney P, Martin AJ, Cooke DL, Wilson MW, Thorne BR, Sincic RS, Arenson RL, Saeed M, Hetts SW. Magnetically assisted remote-controlled endovascular catheter for interventional MR imaging: in vitro navigation at 1.5 T versus X-ray fluoroscopy. Radiology. 2014 Jun; 271(3):862-9. PMID: 24533872; PMCID: PMC4065602.
      25. Amans MR, Cooke DL, Vella M, Dowd CF, Halbach VV, Higashida RT, Hetts SW. Contrast staining on CT after DSA in ischemic stroke patients progresses to infarction and rarely hemorrhages. Interv Neuroradiol. 2014 Jan-Feb; 20(1):106-15. PMID: 24556308; PMCID: PMC3971133.
      26. Sincic RS, Caton CJ, Lillaney P, Goodfriend S, Ni J, Martin AJ, Losey AD, Shah N, Yee EJ, Evans L, Malba V, Bernhardt AF, Settecase F, Cooke DL, Saeed M, Wilson MW, Hetts SW. System architecture for a magnetically guided endovascular microcatheter. Biomed Microdevices. 2014 Feb; 16(1):97-106. PMID: 24132857; PMCID: PMC3945604.
      27. Lillaney P, Caton C, Martin AJ, Losey AD, Evans L, Saeed M, Cooke DL, Wilson MW, Hetts SW. Comparing deflection measurements of a magnetically steerable catheter using optical imaging and MRI. Med Phys. 2014 Feb; 41(2):022305. PMID: 24506643; PMCID: PMC3987686.
      28. Cooke DL, Stout CE, Kim WT, Hetts SW, Higashida RT, Halbach VV, Dowd CF, Gould RG. Radiation dose reduction in intra-arterial chemotherapy infusion for intraocular retinoblastoma. J Neurointerv Surg. 2014 Dec; 6(10):785-9. PMID: 24385553.
        View in: PubMed
      29. Amans MR, Stout C, Fox C, Narvid J, Hetts SW, Cooke DL, Higashida RT, Dowd CF, McSwain H, Halbach VV. Cerebral arteriopathy associated with Arg179His ACTA2 mutation. J Neurointerv Surg. 2014 Nov; 6(9):e46. PMID: 24353327.
        View in: PubMed
      30. Cooke DL, Su H, Sun Z, Guo Y, Guo D, Saeed MM, Hetts SW, Higashida RT, Dowd CF, Young WL, Halbach VV. Endovascular biopsy: evaluating the feasibility of harvesting endothelial cells using detachable coils. Interv Neuroradiol. 2013 Dec; 19(4):399-408. PMID: 24355142; PMCID: PMC3902737.
      31. Hetts SW, English JD, Stiver SI, Singh V, Yee EJ, Cooke DL, Halbach VV. Bilateral cervical spinal dural arteriovenous fistulas with intracranial venous drainage mimicking a foramen magnum dural arteriovenous fistula. Interv Neuroradiol. 2013 Dec; 19(4):483-8. PMID: 24355154; PMCID: PMC3902749.
      32. Amans MR, Stout C, Fox C, Narvid J, Hetts SW, Cooke DL, Higashida RT, Dowd CF, McSwain H, Halbach VV. Cerebral arteriopathy associated with Arg179His ACTA2 mutation. BMJ Case Rep. 2013; 2013. PMID: 24293535.
        View in: PubMed
      33. Sheth SA, Potts MB, Sneed PK, Young WL, Cooke DL, Gupta N, Hetts SW. Angiographic features help predict outcome after stereotactic radiosurgery for the treatment of pediatric arteriovenous malformations. Childs Nerv Syst. 2014 Feb; 30(2):241-7. PMID: 23892391.
        View in: PubMed
      34. Meisel K, Yee A, Stout C, Kim W, Cooke D, Halbach V. Arteriovenous fistula after ventriculostomy in aneurysmal subarachnoid hemorrhage. Neurology. 2013 Jun 4; 80(23):2168. PMID: 23733553.
        View in: PubMed
      35. Thampi S, Hetts SW, Cooke DL, Stewart PJ, Robbins E, Banerjee A, Dubois SG, Char D, Halbach V, Matthay K. Superselective intra-arterial melphalan therapy for newly diagnosed and refractory retinoblastoma: results from a single institution. Clin Ophthalmol. 2013; 7:981-9. PMID: 23818751; PMCID: PMC3693581.
      36. Losey AD, Lillaney P, Martin AJ, Halbach VV, Cooke DL, Dowd CF, Higashida RT, Saloner DA, Wilson MW, Saeed M, Hetts SW. Safety of retained microcatheters: an evaluation of radiofrequency heating in endovascular microcatheters with nitinol, tungsten, and polyetheretherketone braiding at 1.5 T and 3 T. J Neurointerv Surg. 2014 May; 6(4):314-9. PMID: 23685793; PMCID: PMC3796159.
      37. Hetts SW, Saeed M, Martin A, Lillaney P, Losey A, Yee EJ, Sincic R, Do L, Evans L, Malba V, Bernhardt AF, Wilson MW, Patel A, Arenson RL, Caton C, Cooke DL. Magnetically-Assisted Remote Controlled Microcatheter Tip Deflection under Magnetic Resonance Imaging. J Vis Exp. 2013; (74). PMID: 23609143; PMCID: PMC3643177.
      38. Kansagra AP, Cooke DL, English JD, Sincic RM, Amans MR, Dowd CF, Halbach VV, Higashida RT, Hetts SW. Current trends in endovascular management of traumatic cerebrovascular injury. J Neurointerv Surg. 2014 Jan; 6(1):47-50. PMID: 23322749.
        View in: PubMed
      39. Moftakhar P, English JD, Cooke DL, Kim WT, Stout C, Smith WS, Dowd CF, Higashida RT, Halbach VV, Hetts SW. Density of thrombus on admission CT predicts revascularization efficacy in large vessel occlusion acute ischemic stroke. Stroke. 2013 Jan; 44(1):243-5. PMID: 23111438.
        View in: PubMed
      40. Cooke DL, Meisel KM, Kim WT, Stout CE, Halbach VV, Dowd CF, Higashida RT. Serial angiographic appearance of segmental arterial mediolysis manifesting as vertebral, internal mammary and intra-abdominal visceral artery aneurysms in a patient presenting with subarachnoid hemorrhage and review of the literature. J Neurointerv Surg. 2013 Sep 1; 5(5):478-82. PMID: 22693248.
        View in: PubMed
      41. Tatum J, Farid H, Cooke D, Fullerton H, Smith W, Higashida R, Halbach VV, Dowd C. Mechanical embolectomy for treatment of large vessel acute ischemic stroke in children. J Neurointerv Surg. 2013 Mar; 5(2):128-34. PMID: 22307540.
        View in: PubMed
      42. Cooke D, Farid H, Kim W, Dowd C, Higashida R, Halbach V. Zygomatico-orbital intra-arterial melphalan infusion for intraocular retinoblastoma. J Neurointerv Surg. 2012 Jul; 4(4):e16. PMID: 21990490.
        View in: PubMed
      43. Cooke D, Tatum J, Farid H, Dowd C, Higashida R, Halbach V. Transvenous embolization of a pediatric pial arteriovenous fistula. J Neurointerv Surg. 2012 Jul; 4(4):e14. PMID: 21990498.
        View in: PubMed
      44. Cooke DL, Johnson G, Levitt MR, Lewis DH, Sekhar LN, Ghodke B. Synchronous chronic middle cerebral artery occlusion and ipsilateral dural arteriovenous fistula. Clin Nucl Med. 2011 Jul; 36(7):570-3. PMID: 21637062.
        View in: PubMed
      45. Levitt MR, Cooke DL, Ghodke BV, Kim LJ, Hallam DK, Sekhar LN. "Stent view" flat-detector CT and stent-assisted treatment strategies for complex intracranial aneurysms. World Neurosurg. 2011 Feb; 75(2):275-8. PMID: 21492730.
        View in: PubMed
      46. Cooke DL, Levitt M, Kim LJ, Hallam DK, Ghodke B. Intraorbital access using fluoroscopic flat panel detector CT navigation and three-dimensional MRI overlay. J Neurointerv Surg. 2010 Sep; 2(3):249-51. PMID: 21990636.
        View in: PubMed
      47. Levitt MR, Ghodke BV, Cooke DL, Hallam DK, Kim LJ, Sekhar LN. Endovascular procedures with CTA and MRA roadmapping. J Neuroimaging. 2011 Jul; 21(3):259-62. PMID: 20649854.
        View in: PubMed
      48. Cooke D, Seiler D, Hallam D, Kim L, Jarvik JG, Sekhar L, Ghodke B. Does treatment modality affect vasospasm distribution in aneurysmal subarachnoid hemorrhage: differential use of intra-arterial interventions for cerebral vasospasm in surgical clipping and endovascular coiling populations. J Neurointerv Surg. 2010 Jun; 2(2):139-44. PMID: 21990594.
        View in: PubMed
      49. Cooke DL, Levitt M, Kim LJ, Hallam DK, Ghodke B. Transcranial access using fluoroscopic flat panel detector CT navigation. AJNR Am J Neuroradiol. 2011 Apr; 32(4):E69-70. PMID: 20299429.
        View in: PubMed
      50. Cooke D, Koppula B, Seiler D, Rajendran J, Hallam D, Ghodke B, Lewis D. Semiquantitative software SPECT analysis in aneurysmal subarachnoid hemorrhage-related vasospasm. Nucl Med Commun. 2010 Jan; 31(1):53-8. PMID: 19918208.
        View in: PubMed
      51. Wilson MA, Cooke DL, Ghodke B, Mirza SK. Retrospective analysis of preoperative embolization of spinal tumors. AJNR Am J Neuroradiol. 2010 Apr; 31(4):656-60. PMID: 19942697.
        View in: PubMed
      52. Cooke D, Ghodke B, Natarajan SK, Hallam D. Embolization in the head and neck. Semin Intervent Radiol. 2008 Sep; 25(3):293-309. PMID: 21326519; PMCID: PMC3036447.
      53. Konowal A, Morrison JC, Brown SV, Cooke DL, Maguire LJ, Verdier DV, Fraunfelder FT, Dennis RF, Epstein RJ. Irreversible corneal decompensation in patients treated with topical dorzolamide. Am J Ophthalmol. 1999 Apr; 127(4):403-6. PMID: 10218692.
        View in: PubMed
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