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    Julie Zikherman

    TitleAssistant Professor
    SchoolUCSF School of Medicine
    Address513 Parnassus Ave
    San Francisco CA 94143
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      Cornell UniversityM.D.School of Medicine2002

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      Our laboratory is interested in understanding how the normal repertoire of B cell antigen receptors is established during B cell development and how this process is disrupted in autoimmune disease. To do so, we are taking advantage of novel reporter mice in which autoreactive B cells are fluorescently marked. We are combining these reporters with receptor cloning, transcriptome profiling, biochemical analysis of signal transduction, and genetic mouse models in order to dissect how autoreactivity is selected and counterselected in the mature B cell repertoire.

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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Coughlin S, Noviski M, Mueller JL, Chuwonpad A, Raschke WC, Weiss A, Zikherman J. An extracatalytic function of CD45 in B cells is mediated by CD22. Proc Natl Acad Sci U S A. 2015 Nov 24; 112(47):E6515-24. PMID: 26561584; PMCID: PMC4664364 [Available on 05/24/16].
      2. Mills RE, Lam VC, Tan A, Cresalia N, Oksenberg N, Zikherman J, Anderson M, Weiss A, Hermiston ML. Unbiased modifier screen reveals that signal strength determines the regulatory role murine TLR9 plays in autoantibody production. J Immunol. 2015 Apr 15; 194(8):3675-86. PMID: 25769918; PMCID: PMC4503364 [Available on 04/15/16].
      3. Mueller J, Matloubian M, Zikherman J. Cutting edge: An in vivo reporter reveals active B cell receptor signaling in the germinal center. J Immunol. 2015 Apr 1; 194(7):2993-7. PMID: 25725108; PMCID: PMC4369439 [Available on 04/01/16].
      4. Zikherman J, Au-Yeung B. The role of T cell receptor signaling thresholds in guiding T cell fate decisions. Curr Opin Immunol. 2015 Apr; 33:43-8. PMID: 25660212; PMCID: PMC4397149 [Available on 04/01/16].
      5. Au-Yeung BB, Zikherman J, Mueller JL, Ashouri JF, Matloubian M, Cheng DA, Chen Y, Shokat KM, Weiss A. A sharp T-cell antigen receptor signaling threshold for T-cell proliferation. Proc Natl Acad Sci U S A. 2014 Sep 2; 111(35):E3679-88. PMID: 25136127; PMCID: PMC4156735.
      6. Au-Yeung BB, Melichar HJ, Ross JO, Cheng DA, Zikherman J, Shokat KM, Robey EA, Weiss A. Quantitative and temporal requirements revealed for Zap70 catalytic activity during T cell development. Nat Immunol. 2014 Jul; 15(7):687-94. PMID: 24908390; PMCID: PMC4095875.
      7. Limnander A, Zikherman J, Lau T, Leitges M, Weiss A, Roose JP. Protein kinase Cd promotes transitional B cell-negative selection and limits proximal B cell receptor signaling to enforce tolerance. Mol Cell Biol. 2014 Apr; 34(8):1474-85. PMID: 24515435; PMCID: PMC3993585.
      8. Tan YX, Zikherman J, Weiss A. Novel tools to dissect the dynamic regulation of TCR signaling by the kinase Csk and the phosphatase CD45. Cold Spring Harb Symp Quant Biol. 2013; 78:131-9. PMID: 24100586; PMCID: PMC4039614.
      9. Zikherman J, Parameswaran R, Hermiston M, Weiss A. The structural wedge domain of the receptor-like tyrosine phosphatase CD45 enforces B cell tolerance by regulating substrate specificity. J Immunol. 2013 Mar 15; 190(6):2527-35. PMID: 23396948; PMCID: PMC3593789.
      10. Mukherjee S, Zhu J, Zikherman J, Parameswaran R, Kadlecek TA, Wang Q, Au-Yeung B, Ploegh H, Kuriyan J, Das J, Weiss A. Monovalent and multivalent ligation of the B cell receptor exhibit differential dependence upon Syk and Src family kinases. Sci Signal. 2013 Jan 1; 6(256):ra1. PMID: 23281368; PMCID: PMC3742096.
      11. Zikherman J, Parameswaran R, Weiss A. Endogenous antigen tunes the responsiveness of naive B cells but not T cells. Nature. 2012 Sep 6; 489(7414):160-4. PMID: 22902503; PMCID: PMC3438375.
      12. Zikherman J, Doan K, Parameswaran R, Raschke W, Weiss A. Quantitative differences in CD45 expression unmask functions for CD45 in B-cell development, tolerance, and survival. Proc Natl Acad Sci U S A. 2012 Jan 3; 109(1):E3-12. PMID: 22135465; PMCID: PMC3252956.
      13. Zikherman J, Weiss A. Unraveling the functional implications of GWAS: how T cell protein tyrosine phosphatase drives autoimmune disease. J Clin Invest. 2011 Dec; 121(12):4618-21. PMID: 22080861; PMCID: PMC3226009.
      14. Zikherman J, Jenne C, Watson S, Doan K, Raschke W, Goodnow CC, Weiss A. CD45-Csk phosphatase-kinase titration uncouples basal and inducible T cell receptor signaling during thymic development. Immunity. 2010 Mar 26; 32(3):342-54. PMID: 20346773; PMCID: PMC2865198.
      15. Chakraborty AK, Das J, Zikherman J, Yang M, Govern CC, Ho M, Weiss A, Roose J. Molecular origin and functional consequences of digital signaling and hysteresis during Ras activation in lymphocytes. Sci Signal. 2009; 2(66):pt2. PMID: 19366993; PMCID: PMC2755093.
      16. Zikherman J, Hermiston M, Steiner D, Hasegawa K, Chan A, Weiss A. PTPN22 deficiency cooperates with the CD45 E613R allele to break tolerance on a non-autoimmune background. J Immunol. 2009 Apr 1; 182(7):4093-106. PMID: 19299707; PMCID: PMC2765978.
      17. Hermiston ML, Zikherman J, Zhu JW. CD45, CD148, and Lyp/Pep: critical phosphatases regulating Src family kinase signaling networks in immune cells. Immunol Rev. 2009 Mar; 228(1):288-311. PMID: 19290935; PMCID: PMC2739744.
      18. Zikherman J, Weiss A. Antigen receptor signaling in the rheumatic diseases. Arthritis Res Ther. 2009; 11(1):202. PMID: 19232064; PMCID: PMC2688213.
      19. Das J, Ho M, Zikherman J, Govern C, Yang M, Weiss A, Chakraborty AK, Roose JP. Digital signaling and hysteresis characterize ras activation in lymphoid cells. Cell. 2009 Jan 23; 136(2):337-51. PMID: 19167334; PMCID: PMC2662698.
      20. Hermiston ML, Zikherman J, Tan AL, Lam VC, Cresalia NM, Oksenberg N, Goren N, Brassat D, Oksenberg JR, Weiss A. Differential impact of the CD45 juxtamembrane wedge on central and peripheral T cell receptor responses. Proc Natl Acad Sci U S A. 2009 Jan 13; 106(2):546-51. PMID: 19129486; PMCID: PMC2626740.
      21. Zikherman J, Weiss A. Alternative splicing of CD45: the tip of the iceberg. Immunity. 2008 Dec 19; 29(6):839-41. PMID: 19100695.
        View in: PubMed
      22. Prasad A, Zikherman J, Das J, Roose JP, Weiss A, Chakraborty AK. Origin of the sharp boundary that discriminates positive and negative selection of thymocytes. Proc Natl Acad Sci U S A. 2009 Jan 13; 106(2):528-33. PMID: 19098101; PMCID: PMC2626737.
      23. Crowe R, Zikherman J, Niswander L. Delta-1 negatively regulates the transition from prehypertrophic to hypertrophic chondrocytes during cartilage formation. Development. 1999 Feb; 126(5):987-98. PMID: 9927599.
        View in: PubMed
      24. Petanceska S, Zikherman J, Fricker LD, Devi L. Processing of prodynorphin in BRL-3A cells, a rat liver-derived cell line: implications for the specificity of neuropeptide-processing enzymes. Mol Cell Endocrinol. 1993 Jul; 94(1):37-45. PMID: 8375574.
        View in: PubMed
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