|School||UCSF School of Medicine|
|Address||513 Parnassus Ave|
San Francisco CA 94143
|Cornell University||M.D.||School of Medicine||2002|
Our laboratory is interested in understanding how the normal repertoire of B cell antigen receptors is established during B cell development and how this process is disrupted in autoimmune disease. To do so, we are taking advantage of novel reporter mice in which autoreactive B cells are fluorescently marked. We are combining these reporters with receptor cloning, transcriptome profiling, biochemical analysis of signal transduction, and genetic mouse models in order to dissect how autoreactivity is selected and counterselected in the mature B cell repertoire.
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