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Stanley Prusiner, MD

TitleProfessor
SchoolUCSF School of Medicine
DepartmentNeurology
Address675 Nelson Rising Lane
San Francisco CA 94158
Phone415-476-4482
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    Other Positions
    TitleDirector, Institute for Neurodegenerative Diseases
    InstitutionUCSF School of Medicine
    DepartmentNeurology


    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoResidency School of Medicine
    Collapse Awards and Honors
    2009National Medal of Science
    1997Nobel Prize in Physiology or Medicine
    1994Albert Lasker Award for Basic Medical Research

    Collapse Overview 
    Collapse Overview
    Stanley B. Prusiner, MD, is a professor of neurology and biochemistry and director of the Institute for Neurodegenerative Diseases at UCSF. While at the university, Dr. Prusiner discovered an unprecedented class of pathogens that he named prions. Prions are infectious proteins that cause neurodegenerative diseases in animals and humans.

    Dr. Prusiner’s contributions to scientific research have been internationally recognized with numerous prizes including the Richard Lounsbery Award, the Albert Lasker Award and the Nobel Prize.

    Editor of 11 books and more than 500 research articles, Dr. Prusiner holds 50 issued or allowed United States patents, all of which are assigned to the University of California.

    He is a member of the National Academy of Sciences, the Institute of Medicine, the American Academy of Arts and Sciences and the American Philosophical Society, and is a foreign member of the Royal Society, London

    Dr. Prusiner received his undergraduate and medical training at the University of Pennsylvania and his postgraduate clinical training at UCSF.


    Collapse Research 
    Collapse Research Activities and Funding
    Towards Therapeutics for Neurodegenerative Diseases
    NIH/NIA R37AG031220Feb 15, 2008 - Jan 31, 2018
    Role: Principal Investigator
    Preventing Human Prion Diseases - Inactivation of Prions
    NIH/NIAID R01AI064709Apr 1, 2006 - Mar 31, 2011
    Role: Principal Investigator
    Novel Therapeutics for Prion Diseases
    NIH/NIA P01AG021601Jun 1, 2003 - Feb 28, 2014
    Role: Principal Investigator
    Genetics of Prion Susceptibility in vitro
    NIH/NINDS P01NS041997Sep 30, 2001 - Jun 30, 2013
    Role: Co-Investigator
    BIOSAFETY LABORATORY (BSL-3) STUDIES HUMAN/BOVINE PRIONS
    NIH/NCRR C06RR016267Jun 15, 2001 - Jun 14, 2004
    Role: Principal Investigator
    MASS SPECTROMETRY RESOURCE FOR BIOLOGY AND MEDICINE
    NIH P41RR010888Jul 1, 1996 - Aug 9, 2012
    Role: Co-Investigator
    Molecular Pathogenesis of Age-Dependent CNS Regeneration
    NIH/NIA P01AG010770Apr 1, 1993 - Mar 31, 2016
    Role: Principal Investigator
    LEADERSHIP AND EXCELLENCE IN ALZHEIMERS DISEASE
    NIH/NIA R35AG008967May 1, 1990 - Apr 30, 1997
    Role: Principal Investigator
    ELECTRON MICROSCOPE-JEOL 100CX
    NIH/NCRR S10RR004691Mar 30, 1989 - Mar 29, 1990
    Role: Principal Investigator
    TRANSMISSIBLE AND GENETIC NEURODENGENERATIVE DISEASES
    NIH/NINDS P01NS022786Sep 1, 1985 - Jun 30, 2000
    Role: Principal Investigator
    EXPERIMENTAL APPROACHES TO NEURODEGENERATIVE DISEASES
    NIH/NINDS T32NS007219Apr 1, 1982 - Jun 30, 2003
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator
    Degenerative and Dementing Diseases of Aging
    NIH/NIA P01AG002132Jan 1, 1981 - Mar 31, 2020
    Role: Principal Investigator
    DEVELOPMENT OF ASSAY FOR CREUTZFELDT-JAKOB DISEASE-265002328-265002328
    NIH/NINDS N01NS002328Feb 1, 1980 - Sep 28, 2005
    Role: Co-Principal Investigator
    CNS DEGENERATION CAUSED BY NOVEL PATHOGENS
    NIH/NINDS P50NS014069Dec 1, 1977 - Nov 30, 2002
    Role: Principal Investigator
    CNS DEGENERATION CAUSED BY NOVEL PATHOGENS
    NIH/NINDS P01NS014069Dec 1, 1977 - Jun 30, 1997
    Role: Principal Investigator
    General Clinical Research Center
    NIH/NCRR M01RR000079Dec 1, 1974 - Mar 31, 2009
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse In The News
    Collapse Global Health

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Woerman AL, Patel S, Kazmi SA, Oehler A, Freyman Y, Espiritu L, Cotter R, Castaneda JA, Olson SH, Prusiner SB. Kinetics of Human Mutant Tau Prion Formation in the Brains of 2 Transgenic Mouse Lines. JAMA Neurol. 2017 Oct 23. PMID: 29059326.
      View in: PubMed
    2. Woerman AL, Kazmi SA, Patel S, Freyman Y, Oehler A, Aoyagi A, Mordes DA, Halliday GM, Middleton LT, Gentleman SM, Olson SH, Prusiner S. MSA prions exhibit remarkable stability and resistance to inactivation. Acta Neuropathol. 2017 Aug 28. PMID: 28849371.
      View in: PubMed
    3. Stöhr J, Wu H, Nick M, Wu Y, Bhate M, Condello C, Johnson N, Rodgers J, Lemmin T, Acharya S, Becker J, Robinson K, Kelly MJS, Gai F, Stubbs G, Prusiner SB, DeGrado WF. A 31-residue peptide induces aggregation of tau's microtubule-binding region in cells. Nat Chem. 2017 Sep; 9(9):874-881. PMID: 28837163.
      View in: PubMed
    4. Giles K, Olson SH, Prusiner SB. Developing Therapeutics for PrP Prion Diseases. Cold Spring Harb Perspect Med. 2017 Apr 03; 7(4). PMID: 28096242.
      View in: PubMed
    5. Woerman AL, Watts JC, Aoyagi A, Giles K, Middleton LT, Prusiner S. a-Synuclein: Multiple System Atrophy Prions. Cold Spring Harb Perspect Med. 2017 Feb 17. PMID: 28213437.
      View in: PubMed
    6. Watts JC, Prusiner SB. ß-Amyloid Prions and the Pathobiology of Alzheimer's Disease. Cold Spring Harb Perspect Med. 2017 Feb 13. PMID: 28193770.
      View in: PubMed
    7. Watts JC, Prusiner SB. Experimental Models of Inherited PrP Prion Diseases. Cold Spring Harb Perspect Med. 2017 Jan 17. PMID: 28096244.
      View in: PubMed
    8. Woerman AL, Aoyagi A, Patel S, Kazmi SA, Lobach I, Grinberg LT, McKee AC, Seeley WW, Olson SH, Prusiner S. Tau prions from Alzheimer's disease and chronic traumatic encephalopathy patients propagate in cultured cells. Proc Natl Acad Sci U S A. 2016 Dec 13; 113(50):E8187-E8196. PMID: 27911827.
      View in: PubMed
    9. Watts JC, Giles K, Saltzberg DJ, Dugger BN, Patel S, Oehler A, Bhardwaj S, Sali A, Prusiner SB. Guinea Pig Prion Protein Supports Rapid Propagation of Bovine Spongiform Encephalopathy and Variant Creutzfeldt-Jakob Disease Prions. J Virol. 2016 Nov 01; 90(21):9558-9569. PMID: 27440899.
      View in: PubMed
    10. Elkins MR, Wang T, Nick M, Jo H, Lemmin T, Prusiner S, DeGrado WF, Stöhr J, Hong M. Structural Polymorphism of Alzheimer's ß-Amyloid Fibrils as Controlled by an E22 Switch: A Solid-State NMR Study. J Am Chem Soc. 2016 Aug 10; 138(31):9840-52. PMID: 27414264.
      View in: PubMed
    11. Ahlenius H, Chanda S, Webb AE, Yousif I, Karmazin J, Prusiner SB, Brunet A, Südhof TC, Wernig M. FoxO3 regulates neuronal reprogramming of cells from postnatal and aging mice. Proc Natl Acad Sci U S A. 2016 Jul 26; 113(30):8514-9. PMID: 27402759; PMCID: PMC4968717 [Available on 01/26/17].
    12. Watts JC, Giles K, Bourkas ME, Patel S, Oehler A, Gavidia M, Bhardwaj S, Lee J, Prusiner SB. Towards authentic transgenic mouse models of heritable PrP prion diseases. Acta Neuropathol. 2016 Oct; 132(4):593-610. PMID: 27350609.
      View in: PubMed
    13. Giles K, Berry DB, Condello C, Dugger BN, Li Z, Oehler A, Bhardwaj S, Elepano M, Guan S, Silber BM, Olson SH, Prusiner S, et al. Optimization of Aryl Amides that Extend Survival in Prion-Infected Mice. J Pharmacol Exp Ther. 2016 Sep; 358(3):537-47. PMID: 27317802; PMCID: PMC4998675 [Available on 09/01/17].
    14. Prusiner SB, Woerman AL, Mordes DA, Watts JC, Rampersaud R, Berry DB, Patel S, Oehler A, Lowe JK, Kravitz SN, Geschwind DH, Glidden DV, Halliday GM, Middleton LT, Gentleman SM, Grinberg LT, Giles K. Evidence for a-synuclein prions causing multiple system atrophy in humans with parkinsonism. Proc Natl Acad Sci U S A. 2015 Sep 22; 112(38):E5308-17. PMID: 26324905; PMCID: PMC4586853.
    15. Watts JC, Giles K, Serban A, Patel S, Oehler A, Bhardwaj S, Guan S, Greicius MD, Miller BL, DeArmond SJ, Geschwind MD, Prusiner SB. Modulation of Creutzfeldt-Jakob disease prion propagation by the A224V mutation. Ann Neurol. 2015 Oct; 78(4):540-53. PMID: 26094969; PMCID: PMC4711268 [Available on 10/01/16].
    16. Carter L, Kim SJ, Schneidman-Duhovny D, Stöhr J, Poncet-Montange G, Weiss TM, Tsuruta H, Prusiner SB, Sali A. Prion Protein-Antibody Complexes Characterized by Chromatography-Coupled Small-Angle X-Ray Scattering. Biophys J. 2015 Aug 18; 109(4):793-805. PMID: 26287631; PMCID: PMC4547163.
    17. Woerman AL, Stöhr J, Aoyagi A, Rampersaud R, Krejciova Z, Watts JC, Ohyama T, Patel S, Widjaja K, Oehler A, Sanders DW, Diamond MI, Seeley WW, Middleton LT, Gentleman SM, Mordes DA, Südhof TC, Giles K, Prusiner SB. Propagation of prions causing synucleinopathies in cultured cells. Proc Natl Acad Sci U S A. 2015 Sep 01; 112(35):E4949-58. PMID: 26286986; PMCID: PMC4568231.
    18. Giles K, Berry DB, Condello C, Hawley RC, Gallardo-Godoy A, Bryant C, Oehler A, Elepano M, Bhardwaj S, Patel S, Silber BM, Guan S, DeArmond SJ, Renslo AR, Prusiner SB. Different 2-Aminothiazole Therapeutics Produce Distinct Patterns of Scrapie Prion Neuropathology in Mouse Brains. J Pharmacol Exp Ther. 2015 Oct; 355(1):2-12. PMID: 26224882; PMCID: PMC4576665 [Available on 10/01/16].
    19. Berry D, Giles K, Oehler A, Bhardwaj S, DeArmond SJ, Prusiner SB. Use of a 2-aminothiazole to Treat Chronic Wasting Disease in Transgenic Mice. J Infect Dis. 2015 Jul 15; 212 Suppl 1:S17-25. PMID: 26116725; PMCID: PMC4551108.
    20. Wan W, Wille H, Stöhr J, Kendall A, Bian W, McDonald M, Tiggelaar S, Watts JC, Prusiner SB, Stubbs G. Structural studies of truncated forms of the prion protein PrP. Biophys J. 2015 Mar 24; 108(6):1548-54. PMID: 25809267; PMCID: PMC4375555.
    21. Levine DJ, Stöhr J, Falese LE, Ollesch J, Wille H, Prusiner SB, Long JR. Mechanism of scrapie prion precipitation with phosphotungstate anions. ACS Chem Biol. 2015 May 15; 10(5):1269-77. PMID: 25695325; PMCID: PMC4437617.
    22. Watts JC, Condello C, Stöhr J, Oehler A, Lee J, DeArmond SJ, Lannfelt L, Ingelsson M, Giles K, Prusiner SB. Serial propagation of distinct strains of Aß prions from Alzheimer's disease patients. Proc Natl Acad Sci U S A. 2014 Jul 15; 111(28):10323-8. PMID: 24982139; PMCID: PMC4104857.
    23. Stöhr J, Condello C, Watts JC, Bloch L, Oehler A, Nick M, DeArmond SJ, Giles K, DeGrado WF, Prusiner SB. Distinct synthetic Aß prion strains producing different amyloid deposits in bigenic mice. Proc Natl Acad Sci U S A. 2014 Jul 15; 111(28):10329-34. PMID: 24982137; PMCID: PMC4104853.
    24. Watts JC, Prusiner SB. Mouse models for studying the formation and propagation of prions. J Biol Chem. 2014 Jul 18; 289(29):19841-9. PMID: 24860095; PMCID: PMC4106304.
    25. Watts JC, Giles K, Patel S, Oehler A, DeArmond SJ, Prusiner SB. Evidence that bank vole PrP is a universal acceptor for prions. PLoS Pathog. 2014 Apr; 10(4):e1003990. PMID: 24699458; PMCID: PMC3974871.
    26. Silber BM, Gever JR, Rao S, Li Z, Renslo AR, Widjaja K, Wong C, Giles K, Freyman Y, Elepano M, Irwin JJ, Jacobson MP, Prusiner SB. Novel compounds lowering the cellular isoform of the human prion protein in cultured human cells. Bioorg Med Chem. 2014 Mar 15; 22(6):1960-72. PMID: 24530226; PMCID: PMC3984052.
    27. Watts JC, Giles K, Oehler A, Middleton L, Dexter DT, Gentleman SM, DeArmond SJ, Prusiner SB. Transmission of multiple system atrophy prions to transgenic mice. Proc Natl Acad Sci U S A. 2013 Nov 26; 110(48):19555-60. PMID: 24218576; PMCID: PMC3845125.
    28. Berry DB, Lu D, Geva M, Watts JC, Bhardwaj S, Oehler A, Renslo AR, DeArmond SJ, Prusiner SB, Giles K. Drug resistance confounding prion therapeutics. Proc Natl Acad Sci U S A. 2013 Oct 29; 110(44):E4160-9. PMID: 24128760; PMCID: PMC3816483.
    29. Geschwind MD, Kuo AL, Wong KS, Haman A, Devereux G, Raudabaugh BJ, Johnson DY, Torres-Chae CC, Finley R, Garcia P, Thai JN, Cheng HQ, Neuhaus JM, Forner SA, Duncan JL, Possin KL, Dearmond SJ, Prusiner SB, Miller BL. Quinacrine treatment trial for sporadic Creutzfeldt-Jakob disease. Neurology. 2013 Dec 03; 81(23):2015-23. PMID: 24122181; PMCID: PMC4211922.
    30. Silber BM, Gever JR, Li Z, Gallardo-Godoy A, Renslo AR, Widjaja K, Irwin JJ, Rao S, Jacobson MP, Ghaemmaghami S, Prusiner SB. Antiprion compounds that reduce PrP(Sc) levels in dividing and stationary-phase cells. Bioorg Med Chem. 2013 Dec 15; 21(24):7999-8012. PMID: 24183589; PMCID: PMC3984054.
    31. Dehdashti SJ, Zheng W, Gever JR, Wilhelm R, Nguyen DT, Sittampalam G, McKew JC, Austin CP, Prusiner SB. A high-throughput screening assay for determining cellular levels of total tau protein. Curr Alzheimer Res. 2013 Sep; 10(7):679-87. PMID: 23905996; PMCID: PMC4010324.
    32. Lu D, Giles K, Li Z, Rao S, Dolghih E, Gever JR, Geva M, Elepano ML, Oehler A, Bryant C, Renslo AR, Jacobson MP, Dearmond SJ, Silber BM, Prusiner SB. Biaryl amides and hydrazones as therapeutics for prion disease in transgenic mice. J Pharmacol Exp Ther. 2013 Nov; 347(2):325-38. PMID: 23965382; PMCID: PMC3807058.
    33. Li Z, Rao S, Gever JR, Widjaja K, Prusiner S, Silber BM. Optimization of Arylamides as Novel, Potent and Brain-penetrant Antiprion Lead Compounds. ACS Med Chem Lett. 2013 Jul 11; 4(7):647-650. PMID: 23977416.
      View in: PubMed
    34. Godsave SF, Wille H, Pierson J, Prusiner SB, Peters PJ. Plasma membrane invaginations containing clusters of full-length PrPSc are an early form of prion-associated neuropathology in vivo. Neurobiol Aging. 2013 Jun; 34(6):1621-31. PMID: 23481568; PMCID: PMC3596824.
    35. Li Z, Gever J, Rao S, Widjaja K, Prusiner S, Silber BM. Discovery and Preliminary SAR of Arylpiperazines as Novel, Brainpenetrant Antiprion Compounds. ACS Med Chem Lett. 2013 Apr 11; 4(4):397-401. PMID: 23847718.
      View in: PubMed
    36. Li Z, Silber BM, Rao S, Gever JR, Bryant C, Gallardo-Godoy A, Dolghih E, Widjaja K, Elepano M, Jacobson MP, Prusiner SB, Renslo AR. 2-Aminothiazoles with improved pharmacotherapeutic properties for treatment of prion disease. ChemMedChem. 2013 May; 8(5):847-57. PMID: 23509039; PMCID: PMC3984044.
    37. Ghaemmaghami S, Colby DW, Nguyen HO, Hayashi S, Oehler A, DeArmond SJ, Prusiner SB. Convergent replication of mouse synthetic prion strains. Am J Pathol. 2013 Mar; 182(3):866-74. PMID: 23438476; PMCID: PMC3586687.
    38. Silber BM, Rao S, Fife KL, Gallardo-Godoy A, Renslo AR, Dalvie DK, Giles K, Freyman Y, Elepano M, Gever JR, Li Z, Jacobson MP, Huang Y, Benet LZ, Prusiner SB. Pharmacokinetics and metabolism of 2-aminothiazoles with antiprion activity in mice. Pharm Res. 2013 Apr; 30(4):932-50. PMID: 23417511; PMCID: PMC3640342.
    39. Prusiner SB. Biology and genetics of prions causing neurodegeneration. Annu Rev Genet. 2013; 47:601-23. PMID: 24274755; PMCID: PMC4010318.
    40. Tamgüney G, Giles K, Oehler A, Johnson NL, DeArmond SJ, Prusiner SB. Chimeric elk/mouse prion proteins in transgenic mice. J Gen Virol. 2013 Feb; 94(Pt 2):443-52. PMID: 23100369; PMCID: PMC3709613.
    41. Stanker LH, Scotcher MC, Lin A, McGarvey J, Prusiner SB, Hnasko R. Novel epitopes identified by anti-PrP monoclonal antibodies produced following immunization of Prnp0/0 Balb/cJ mice with purified scrapie prions. Hybridoma (Larchmt). 2012 Oct; 31(5):314-24. PMID: 23098297; PMCID: PMC3482378.
    42. Ahn M, Ghaemmaghami S, Huang Y, Phuan PW, May BC, Giles K, DeArmond SJ, Prusiner SB. Pharmacokinetics of quinacrine efflux from mouse brain via the P-glycoprotein efflux transporter. PLoS One. 2012; 7(7):e39112. PMID: 22768295; PMCID: PMC3388068.
    43. Prusiner SB. Cell biology. A unifying role for prions in neurodegenerative diseases. Science. 2012 Jun 22; 336(6088):1511-3. PMID: 22723400; PMCID: PMC3942086.
    44. Stöhr J, Watts JC, Mensinger ZL, Oehler A, Grillo SK, DeArmond SJ, Prusiner SB, Giles K. Purified and synthetic Alzheimer's amyloid beta (Aß) prions. Proc Natl Acad Sci U S A. 2012 Jul 03; 109(27):11025-30. PMID: 22711819; PMCID: PMC3390876.
    45. Wan W, Wille H, Stöhr J, Baxa U, Prusiner SB, Stubbs G. Degradation of fungal prion HET-s(218-289) induces formation of a generic amyloid fold. Biophys J. 2012 May 16; 102(10):2339-44. PMID: 22677387; PMCID: PMC3353098.
    46. Guan S, Price JC, Ghaemmaghami S, Prusiner SB, Burlingame AL. Compartment modeling for mammalian protein turnover studies by stable isotope metabolic labeling. Anal Chem. 2012 May 01; 84(9):4014-21. PMID: 22444387; PMCID: PMC3923578.
    47. Giles K, De Nicola GF, Patel S, Glidden DV, Korth C, Oehler A, DeArmond SJ, Prusiner SB. Identification of I137M and other mutations that modulate incubation periods for two human prion strains. J Virol. 2012 Jun; 86(11):6033-41. PMID: 22438549; PMCID: PMC3372217.
    48. Watts JC, Giles K, Stöhr J, Oehler A, Bhardwaj S, Grillo SK, Patel S, DeArmond SJ, Prusiner SB. Spontaneous generation of rapidly transmissible prions in transgenic mice expressing wild-type bank vole prion protein. Proc Natl Acad Sci U S A. 2012 Feb 28; 109(9):3498-503. PMID: 22331873; PMCID: PMC3295307.
    49. Nazor Friberg K, Hung G, Wancewicz E, Giles K, Black C, Freier S, Bennett F, Dearmond SJ, Freyman Y, Lessard P, Ghaemmaghami S, Prusiner SB. Intracerebral Infusion of Antisense Oligonucleotides Into Prion-infected Mice. Mol Ther Nucleic Acids. 2012 Feb 07; 1:e9. PMID: 23344724; PMCID: PMC3381600.
    50. Tamgüney G, Richt JA, Hamir AN, Greenlee JJ, Miller MW, Wolfe LL, Sirochman TM, Young AJ, Glidden DV, Johnson NL, Giles K, DeArmond SJ, Prusiner SB. Salivary prions in sheep and deer. Prion. 2012 Jan-Mar; 6(1):52-61. PMID: 22453179; PMCID: PMC3338966.
    51. Kujala P, Raymond CR, Romeijn M, Godsave SF, van Kasteren SI, Wille H, Prusiner SB, Mabbott NA, Peters PJ. Prion uptake in the gut: identification of the first uptake and replication sites. PLoS Pathog. 2011 Dec; 7(12):e1002449. PMID: 22216002; PMCID: PMC3245311.
    52. Stöhr J, Watts JC, Legname G, Oehler A, Lemus A, Nguyen HO, Sussman J, Wille H, DeArmond SJ, Prusiner SB, Giles K. Spontaneous generation of anchorless prions in transgenic mice. Proc Natl Acad Sci U S A. 2011 Dec 27; 108(52):21223-8. PMID: 22160704; PMCID: PMC3248514.
    53. Watts JC, Stöhr J, Bhardwaj S, Wille H, Oehler A, Dearmond SJ, Giles K, Prusiner SB. Protease-resistant prions selectively decrease Shadoo protein. PLoS Pathog. 2011 Nov; 7(11):e1002382. PMID: 22163178; PMCID: PMC3219722.
    54. Colby DW, Prusiner SB. De novo generation of prion strains. Nat Rev Microbiol. 2011 Sep 26; 9(11):771-7. PMID: 21947062; PMCID: PMC3924856.
    55. Guan S, Price JC, Prusiner SB, Ghaemmaghami S, Burlingame AL. A data processing pipeline for mammalian proteome dynamics studies using stable isotope metabolic labeling. Mol Cell Proteomics. 2011 Dec; 10(12):M111.010728. PMID: 21937731; PMCID: PMC3237081.
    56. Ghaemmaghami S, Watts JC, Nguyen HO, Hayashi S, DeArmond SJ, Prusiner SB. Conformational transformation and selection of synthetic prion strains. J Mol Biol. 2011 Oct 28; 413(3):527-42. PMID: 21839745; PMCID: PMC3195964.
    57. Safar JG, Giles K, Lessard P, Letessier F, Patel S, Serban A, Dearmond SJ, Prusiner SB. Conserved properties of human and bovine prion strains on transmission to guinea pigs. Lab Invest. 2011 Sep; 91(9):1326-36. PMID: 21727894; PMCID: PMC3164925.
    58. Poncet-Montange G, St Martin SJ, Bogatova OV, Prusiner SB, Shoichet BK, Ghaemmaghami S. A survey of antiprion compounds reveals the prevalence of non-PrP molecular targets. J Biol Chem. 2011 Aug 05; 286(31):27718-28. PMID: 21610081; PMCID: PMC3149362.
    59. Watts JC, Giles K, Grillo SK, Lemus A, DeArmond SJ, Prusiner SB. Bioluminescence imaging of Abeta deposition in bigenic mouse models of Alzheimer's disease. Proc Natl Acad Sci U S A. 2011 Feb 08; 108(6):2528-33. PMID: 21262831; PMCID: PMC3038719.
    60. Gallardo-Godoy A, Gever J, Fife KL, Silber BM, Prusiner SB, Renslo AR. 2-Aminothiazoles as therapeutic leads for prion diseases. J Med Chem. 2011 Feb 24; 54(4):1010-21. PMID: 21247166; PMCID: PMC3041857.
    61. Colby DW, Prusiner SB. Prions. Cold Spring Harb Perspect Biol. 2011 Jan 01; 3(1):a006833. PMID: 21421910; PMCID: PMC3003464.
    62. Price JC, Guan S, Burlingame A, Prusiner SB, Ghaemmaghami S. Analysis of proteome dynamics in the mouse brain. Proc Natl Acad Sci U S A. 2010 Aug 10; 107(32):14508-13. PMID: 20699386; PMCID: PMC2922600.
    63. Giles K, Glidden DV, Patel S, Korth C, Groth D, Lemus A, DeArmond SJ, Prusiner SB. Human prion strain selection in transgenic mice. Ann Neurol. 2010 Aug; 68(2):151-61. PMID: 20695008; PMCID: PMC2935907.
    64. Stanker LH, Serban AV, Cleveland E, Hnasko R, Lemus A, Safar J, DeArmond SJ, Prusiner SB. Conformation-dependent high-affinity monoclonal antibodies to prion proteins. J Immunol. 2010 Jul 01; 185(1):729-37. PMID: 20530267; PMCID: PMC2957185.
    65. Doak AK, Wille H, Prusiner SB, Shoichet BK. Colloid formation by drugs in simulated intestinal fluid. J Med Chem. 2010 May 27; 53(10):4259-65. PMID: 20426472; PMCID: PMC2874266.
    66. Hnasko R, Serban AV, Carlson G, Prusiner SB, Stanker LH. Generation of antisera to purified prions in lipid rafts. Prion. 2010 Apr-Jun; 4(2):94-104. PMID: 20647769; PMCID: PMC2933057.
    67. Colby DW, Wain R, Baskakov IV, Legname G, Palmer CG, Nguyen HO, Lemus A, Cohen FE, DeArmond SJ, Prusiner SB. Protease-sensitive synthetic prions. PLoS Pathog. 2010 Jan 22; 6(1):e1000736. PMID: 20107515; PMCID: PMC2809756.
    68. Ghaemmaghami S, May BC, Renslo AR, Prusiner SB. Discovery of 2-aminothiazoles as potent antiprion compounds. J Virol. 2010 Apr; 84(7):3408-12. PMID: 20032192; PMCID: PMC2838138.
    69. Ghaemmaghami S, Ullman J, Ahn M, St Martin S, Prusiner SB. Chemical induction of misfolded prion protein conformers in cell culture. J Biol Chem. 2010 Apr 02; 285(14):10415-23. PMID: 19955177; PMCID: PMC2856248.
    70. Colby DW, Giles K, Legname G, Wille H, Baskakov IV, DeArmond SJ, Prusiner SB. Design and construction of diverse mammalian prion strains. Proc Natl Acad Sci U S A. 2009 Dec 01; 106(48):20417-22. PMID: 19915150; PMCID: PMC2787151.
    71. Wille H, Bian W, McDonald M, Kendall A, Colby DW, Bloch L, Ollesch J, Borovinskiy AL, Cohen FE, Prusiner SB, Stubbs G. Natural and synthetic prion structure from X-ray fiber diffraction. Proc Natl Acad Sci U S A. 2009 Oct 06; 106(40):16990-5. PMID: 19805070; PMCID: PMC2761340.
    72. Tamgüney G, Miller MW, Wolfe LL, Sirochman TM, Glidden DV, Palmer C, Lemus A, DeArmond SJ, Prusiner SB. Asymptomatic deer excrete infectious prions in faeces. Nature. 2009 Sep 24; 461(7263):529-32. PMID: 19741608; PMCID: PMC3186440.
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    75. Olanow CW, Prusiner SB. Is Parkinson's disease a prion disorder? Proc Natl Acad Sci U S A. 2009 Aug 04; 106(31):12571-2. PMID: 19666621; PMCID: PMC2722298.
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    77. Campana V, Zentilin L, Mirabile I, Kranjc A, Casanova P, Giacca M, Prusiner SB, Legname G, Zurzolo C. Development of antibody fragments for immunotherapy of prion diseases. Biochem J. 2009 Mar 15; 418(3):507-15. PMID: 19000036.
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    79. Wille H, Shanmugam M, Murugesu M, Ollesch J, Stubbs G, Long JR, Safar JG, Prusiner SB. Surface charge of polyoxometalates modulates polymerization of the scrapie prion protein. Proc Natl Acad Sci U S A. 2009 Mar 10; 106(10):3740-5. PMID: 19223590; PMCID: PMC2656150.
    80. Godsave SF, Wille H, Kujala P, Latawiec D, DeArmond SJ, Serban A, Prusiner SB, Peters PJ. Cryo-immunogold electron microscopy for prions: toward identification of a conversion site. J Neurosci. 2008 Nov 19; 28(47):12489-99. PMID: 19020041; PMCID: PMC2796247.
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    82. Spilman P, Lessard P, Sattavat M, Bush C, Tousseyn T, Huang EJ, Giles K, Golde T, Das P, Fauq A, Prusiner SB, Dearmond SJ. A gamma-secretase inhibitor and quinacrine reduce prions and prevent dendritic degeneration in murine brains. Proc Natl Acad Sci U S A. 2008 Jul 29; 105(30):10595-600. PMID: 18647832; PMCID: PMC2492499.
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    86. Feng BY, Toyama BH, Wille H, Colby DW, Collins SR, May BC, Prusiner SB, Weissman J, Shoichet BK. Small-molecule aggregates inhibit amyloid polymerization. Nat Chem Biol. 2008 Mar; 4(3):197-9. PMID: 18223646; PMCID: PMC2730835.
    87. Colby DW, Zhang Q, Wang S, Groth D, Legname G, Riesner D, Prusiner SB. Prion detection by an amyloid seeding assay. Proc Natl Acad Sci U S A. 2007 Dec 26; 104(52):20914-9. PMID: 18096717; PMCID: PMC2409241.
    88. Ghaemmaghami S, Phuan PW, Perkins B, Ullman J, May BC, Cohen FE, Prusiner SB. Cell division modulates prion accumulation in cultured cells. Proc Natl Acad Sci U S A. 2007 Nov 13; 104(46):17971-6. PMID: 17989223; PMCID: PMC2084281.
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    91. Norrby E, Prusiner SB. Polio and Nobel prizes: looking back 50 years. Ann Neurol. 2007 May; 61(5):385-95. PMID: 17469121.
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    94. Philipp WJ, Groth D, Giles K, Vodrazka P, Schimmel H, Feyssaguet M, Toomik R, Schacher P, Osman AA, Lachmann I, Wear A, Arsac JN, Prusiner SB. Transgenic mouse brains for the evaluation and quality control of BSE tests. Biol Chem. 2007 Mar; 388(3):349-54. PMID: 17338644.
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    96. May BC, Zorn JA, Witkop J, Sherrill J, Wallace AC, Legname G, Prusiner SB, Cohen FE. Structure-activity relationship study of prion inhibition by 2-aminopyridine-3,5-dicarbonitrile-based compounds: parallel synthesis, bioactivity, and in vitro pharmacokinetics. J Med Chem. 2007 Jan 11; 50(1):65-73. PMID: 17201410.
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    100. Boy J, Leergaard TB, Schmidt T, Odeh F, Bichelmeier U, Nuber S, Holzmann C, Wree A, Prusiner SB, Bujard H, Riess O, Bjaalie JG. Expression mapping of tetracycline-responsive prion protein promoter: digital atlasing for generating cell-specific disease models. Neuroimage. 2006 Nov 01; 33(2):449-62. PMID: 16931059.
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    102. Luginbühl B, Kanyo Z, Jones RM, Fletterick RJ, Prusiner SB, Cohen FE, Williamson RA, Burton DR, Plückthun A. Directed evolution of an anti-prion protein scFv fragment to an affinity of 1 pM and its structural interpretation. J Mol Biol. 2006 Oct 13; 363(1):75-97. PMID: 16962610.
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    104. Leclerc E, Serban H, Prusiner SB, Burton DR, Williamson RA. Copper induces conformational changes in the N-terminal part of cell-surface PrPC. Arch Virol. 2006 Nov; 151(11):2103-9. PMID: 16791441.
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    105. Diez M, Groth D, DeArmond SJ, Prusiner SB, Hökfelt T. Changes in neuropeptide expression in mice infected with prions. Neurobiol Aging. 2007 May; 28(5):748-65. PMID: 16621165.
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    106. Huang Y, Okochi H, May BC, Legname G, Prusiner SB, Benet LZ, Guglielmo BJ, Lin ET. Quinacrine is mainly metabolized to mono-desethyl quinacrine by CYP3A4/5 and its brain accumulation is limited by P-glycoprotein. Drug Metab Dispos. 2006 Jul; 34(7):1136-44. PMID: 16581945.
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    107. Giri RK, Young R, Pitstick R, DeArmond SJ, Prusiner SB, Carlson GA. Prion infection of mouse neurospheres. Proc Natl Acad Sci U S A. 2006 Mar 07; 103(10):3875-80. PMID: 16495413; PMCID: PMC1533787.
    108. Peretz D, Supattapone S, Giles K, Vergara J, Freyman Y, Lessard P, Safar JG, Glidden DV, McCulloch C, Nguyen HO, Scott M, Dearmond SJ, Prusiner SB. Inactivation of prions by acidic sodium dodecyl sulfate. J Virol. 2006 Jan; 80(1):322-31. PMID: 16352557; PMCID: PMC1317507.
    109. Prusiner SB, McCarty M. Discovering DNA encodes heredity and prions are infectious proteins. Annu Rev Genet. 2006; 40:25-45. PMID: 17094736.
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    110. Kanaani J, Prusiner SB, Diacovo J, Baekkeskov S, Legname G. Recombinant prion protein induces rapid polarization and development of synapses in embryonic rat hippocampal neurons in vitro. J Neurochem. 2005 Dec; 95(5):1373-86. PMID: 16313516.
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    111. Lim KH, Nguyen TN, Damo SM, Mazur T, Ball HL, Prusiner SB, Pines A, Wemmer DE. Solid-state NMR structural studies of the fibril form of a mutant mouse prion peptide PrP89-143(P101L). Solid State Nucl Magn Reson. 2006 Feb; 29(1-3):183-90. PMID: 16256316.
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    112. Lee IS, Long JR, Prusiner SB, Safar JG. Selective precipitation of prions by polyoxometalate complexes. J Am Chem Soc. 2005 Oct 12; 127(40):13802-3. PMID: 16201796.
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    116. Scott MR, Peretz D, Nguyen HO, Dearmond SJ, Prusiner SB. Transmission barriers for bovine, ovine, and human prions in transgenic mice. J Virol. 2005 May; 79(9):5259-71. PMID: 15827140; PMCID: PMC1082721.
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    119. Ishikura N, Clever JL, Bouzamondo-Bernstein E, Samayoa E, Prusiner SB, Huang EJ, DeArmond SJ. Notch-1 activation and dendritic atrophy in prion disease. Proc Natl Acad Sci U S A. 2005 Jan 18; 102(3):886-91. PMID: 15640354; PMCID: PMC545568.
    120. Requena JR, Dimitrova MN, Legname G, Teijeira S, Prusiner SB, Levine RL. Oxidation of methionine residues in the prion protein by hydrogen peroxide. Arch Biochem Biophys. 2004 Dec 15; 432(2):188-95. PMID: 15542057.
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    121. Yung L, Huang Y, Lessard P, Legname G, Lin ET, Baldwin M, Prusiner SB, Ryou C, Guglielmo BJ. Pharmacokinetics of quinacrine in the treatment of prion disease. BMC Infect Dis. 2004 Nov 29; 4:53. PMID: 15569390; PMCID: PMC535929.
    122. Serban A, Legname G, Hansen K, Kovaleva N, Prusiner SB. Immunoglobulins in urine of hamsters with scrapie. J Biol Chem. 2004 Nov 19; 279(47):48817-20. PMID: 15310752.
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    123. Bouzamondo-Bernstein E, Hopkins SD, Spilman P, Uyehara-Lock J, Deering C, Safar J, Prusiner SB, Ralston HJ, DeArmond SJ. The neurodegeneration sequence in prion diseases: evidence from functional, morphological and ultrastructural studies of the GABAergic system. J Neuropathol Exp Neurol. 2004 Aug; 63(8):882-99. PMID: 15330342.
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    124. Legname G, Baskakov IV, Nguyen HO, Riesner D, Cohen FE, DeArmond SJ, Prusiner SB. Synthetic mammalian prions. Science. 2004 Jul 30; 305(5684):673-6. PMID: 15286374.
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    125. Prusiner SB. Detecting mad cow disease. Sci Am. 2004 Jul; 291(1):86-93. PMID: 15255592.
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    128. May BC, Govaerts C, Prusiner SB, Cohen FE. Prions: so many fibers, so little infectivity. Trends Biochem Sci. 2004 Apr; 29(4):162-5. PMID: 15124628.
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    129. Baskakov IV, Legname G, Gryczynski Z, Prusiner SB. The peculiar nature of unfolding of the human prion protein. Protein Sci. 2004 Mar; 13(3):586-95. PMID: 14767078; PMCID: PMC2286731.
    130. Goldman JS, Miller BL, Safar J, de Tourreil S, Martindale JL, Prusiner SB, Geschwind MD. When sporadic disease is not sporadic: the potential for genetic etiology. Arch Neurol. 2004 Feb; 61(2):213-6. PMID: 14967768.
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    131. Tremblay P, Ball HL, Kaneko K, Groth D, Hegde RS, Cohen FE, DeArmond SJ, Prusiner SB, Safar JG. Mutant PrPSc conformers induced by a synthetic peptide and several prion strains. J Virol. 2004 Feb; 78(4):2088-99. PMID: 14747574; PMCID: PMC369494.
    132. Prusiner SB. Early evidence that a protease-resistant protein is an active component of the infectious prion. Cell. 2004 Jan 23; 116(2 Suppl):S109, 1 p following S113. PMID: 15055596.
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    135. Burns CS, Aronoff-Spencer E, Legname G, Prusiner SB, Antholine WE, Gerfen GJ, Peisach J, Millhauser GL. Copper coordination in the full-length, recombinant prion protein. Biochemistry. 2003 Jun 10; 42(22):6794-803. PMID: 12779334; PMCID: PMC2905145.
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    137. Ryou C, Prusiner SB, Legname G. Cooperative binding of dominant-negative prion protein to kringle domains. J Mol Biol. 2003 May 30; 329(2):323-33. PMID: 12758079.
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    138. Korth C, Kaneko K, Groth D, Heye N, Telling G, Mastrianni J, Parchi P, Gambetti P, Will R, Ironside J, Heinrich C, Tremblay P, DeArmond SJ, Prusiner SB. Abbreviated incubation times for human prions in mice expressing a chimeric mouse-human prion protein transgene. Proc Natl Acad Sci U S A. 2003 Apr 15; 100(8):4784-9. PMID: 12684540; PMCID: PMC153633.
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    142. Qin K, Coomaraswamy J, Mastrangelo P, Yang Y, Lugowski S, Petromilli C, Prusiner SB, Fraser PE, Goldberg JM, Chakrabartty A, Westaway D. The PrP-like protein Doppel binds copper. J Biol Chem. 2003 Mar 14; 278(11):8888-96. PMID: 12482851.
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    143. Prusiner SB. Historical essay. Discovering the cause of AIDS. Science. 2002 Nov 29; 298(5599):1726. PMID: 12459574.
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    146. Kuwata K, Li H, Yamada H, Legname G, Prusiner SB, Akasaka K, James TL. Locally disordered conformer of the hamster prion protein: a crucial intermediate to PrPSc? Biochemistry. 2002 Oct 15; 41(41):12277-83. PMID: 12369815.
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    147. Perrier V, Kaneko K, Safar J, Vergara J, Tremblay P, DeArmond SJ, Cohen FE, Prusiner SB, Wallace AC. Dominant-negative inhibition of prion replication in transgenic mice. Proc Natl Acad Sci U S A. 2002 Oct 01; 99(20):13079-84. PMID: 12271119; PMCID: PMC130589.
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    149. Baskakov IV, Legname G, Baldwin MA, Prusiner SB, Cohen FE. Pathway complexity of prion protein assembly into amyloid. J Biol Chem. 2002 Jun 14; 277(24):21140-8. PMID: 11912192.
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    150. Bosque PJ, Ryou C, Telling G, Peretz D, Legname G, DeArmond SJ, Prusiner SB. Prions in skeletal muscle. Proc Natl Acad Sci U S A. 2002 Mar 19; 99(6):3812-7. PMID: 11904434; PMCID: PMC122606.
    151. Wille H, Michelitsch MD, Guenebaut V, Supattapone S, Serban A, Cohen FE, Agard DA, Prusiner SB. Structural studies of the scrapie prion protein by electron crystallography. Proc Natl Acad Sci U S A. 2002 Mar 19; 99(6):3563-8. PMID: 11891310; PMCID: PMC122563.
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    153. Mastrianni JA, Capellari S, Telling GC, Han D, Bosque P, Prusiner SB, DeArmond SJ. Inherited prion disease caused by the V210I mutation: transmission to transgenic mice. Neurology. 2001 Dec 26; 57(12):2198-205. PMID: 11756597.
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    154. Schmitt-Ulms G, Legname G, Baldwin MA, Ball HL, Bradon N, Bosque PJ, Crossin KL, Edelman GM, DeArmond SJ, Cohen FE, Prusiner SB. Binding of neural cell adhesion molecules (N-CAMs) to the cellular prion protein. J Mol Biol. 2001 Dec 14; 314(5):1209-25. PMID: 11743735.
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    155. Moore RC, Mastrangelo P, Bouzamondo E, Heinrich C, Legname G, Prusiner SB, Hood L, Westaway D, DeArmond SJ, Tremblay P. Doppel-induced cerebellar degeneration in transgenic mice. Proc Natl Acad Sci U S A. 2001 Dec 18; 98(26):15288-93. PMID: 11734625; PMCID: PMC65022.
    156. Ball HL, King DS, Cohen FE, Prusiner SB, Baldwin MA. Engineering the prion protein using chemical synthesis. J Pept Res. 2001 Nov; 58(5):357-74. PMID: 11892845.
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    157. Moore RC, Xiang F, Monaghan J, Han D, Zhang Z, Edström L, Anvret M, Prusiner SB. Huntington disease phenocopy is a familial prion disease. Am J Hum Genet. 2001 Dec; 69(6):1385-8. PMID: 11593450; PMCID: PMC1235549.
    158. Schlumpberger M, Prusiner SB, Herskowitz I. Induction of distinct [URE3] yeast prion strains. Mol Cell Biol. 2001 Oct; 21(20):7035-46. PMID: 11564886; PMCID: PMC99879.
    159. Laws DD, Bitter HM, Liu K, Ball HL, Kaneko K, Wille H, Cohen FE, Prusiner SB, Pines A, Wemmer DE. Solid-state NMR studies of the secondary structure of a mutant prion protein fragment of 55 residues that induces neurodegeneration. Proc Natl Acad Sci U S A. 2001 Sep 25; 98(20):11686-90. PMID: 11562491; PMCID: PMC58790.
    160. Peretz D, Williamson RA, Kaneko K, Vergara J, Leclerc E, Schmitt-Ulms G, Mehlhorn IR, Legname G, Wormald MR, Rudd PM, Dwek RA, Burton DR, Prusiner SB. Antibodies inhibit prion propagation and clear cell cultures of prion infectivity. Nature. 2001 Aug 16; 412(6848):739-43. PMID: 11507642.
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    161. Korth C, May BC, Cohen FE, Prusiner SB. Acridine and phenothiazine derivatives as pharmacotherapeutics for prion disease. Proc Natl Acad Sci U S A. 2001 Aug 14; 98(17):9836-41. PMID: 11504948; PMCID: PMC55539.
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    178. Aronoff-Spencer E, Burns CS, Avdievich NI, Gerfen GJ, Peisach J, Antholine WE, Ball HL, Cohen FE, Prusiner SB, Millhauser GL. Identification of the Cu2+ binding sites in the N-terminal domain of the prion protein by EPR and CD spectroscopy. Biochemistry. 2000 Nov 14; 39(45):13760-71. PMID: 11076515; PMCID: PMC2903970.
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    189. Schlumpberger M, Wille H, Baldwin MA, Butler DA, Herskowitz I, Prusiner SB. The prion domain of yeast Ure2p induces autocatalytic formation of amyloid fibers by a recombinant fusion protein. Protein Sci. 2000 Mar; 9(3):440-51. PMID: 10752606; PMCID: PMC2144574.
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    201. Nishida N, Tremblay P, Sugimoto T, Shigematsu K, Shirabe S, Petromilli C, Erpel SP, Nakaoke R, Atarashi R, Houtani T, Torchia M, Sakaguchi S, DeArmond SJ, Prusiner SB, Katamine S. A mouse prion protein transgene rescues mice deficient for the prion protein gene from purkinje cell degeneration and demyelination. Lab Invest. 1999 Jun; 79(6):689-97. PMID: 10378511.
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    262. Riesner D, Kellings K, Post K, Wille H, Serban H, Groth D, Baldwin MA, Prusiner SB. Disruption of prion rods generates 10-nm spherical particles having high alpha-helical content and lacking scrapie infectivity. J Virol. 1996 Mar; 70(3):1714-22. PMID: 8627692; PMCID: PMC189995.
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    268. Wille H, Baldwin MA, Cohen FE, DeArmond SJ, Prusiner SB. Prion protein amyloid: separation of scrapie infectivity from PrP polymers. Ciba Found Symp. 1996; 199:181-99; discussion 199-201. PMID: 8915611.
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    270. Guan Z, Söderberg M, Sindelar P, Prusiner SB, Kristensson K, Dallner G. Lipid composition in scrapie-infected mouse brain: prion infection increases the levels of dolichyl phosphate and ubiquinone. J Neurochem. 1996 Jan; 66(1):277-85. PMID: 8522965.
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    275. Kaneko K, Peretz D, Pan KM, Blochberger TC, Wille H, Gabizon R, Griffith OH, Cohen FE, Baldwin MA, Prusiner SB. Prion protein (PrP) synthetic peptides induce cellular PrP to acquire properties of the scrapie isoform. Proc Natl Acad Sci U S A. 1995 Nov 21; 92(24):11160-4. PMID: 7479957; PMCID: PMC40591.
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    277. Telling GC, Scott M, Mastrianni J, Gabizon R, Torchia M, Cohen FE, DeArmond SJ, Prusiner SB. Prion propagation in mice expressing human and chimeric PrP transgenes implicates the interaction of cellular PrP with another protein. Cell. 1995 Oct 06; 83(1):79-90. PMID: 7553876.
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    278. Wiese U, Wulfert M, Prusiner SB, Riesner D. Scanning for mutations in the human prion protein open reading frame by temporal temperature gradient gel electrophoresis. Electrophoresis. 1995 Oct; 16(10):1851-60. PMID: 8586053.
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    280. Spudich S, Mastrianni JA, Wrensch M, Gabizon R, Meiner Z, Kahana I, Rosenmann H, Kahana E, Prusiner SB. Complete penetrance of Creutzfeldt-Jakob disease in Libyan Jews carrying the E200K mutation in the prion protein gene. Mol Med. 1995 Sep; 1(6):607-13. PMID: 8529127; PMCID: PMC2229975.
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    282. Zhang H, Kaneko K, Nguyen JT, Livshits TL, Baldwin MA, Cohen FE, James TL, Prusiner SB. Conformational transitions in peptides containing two putative alpha-helices of the prion protein. J Mol Biol. 1995 Jul 21; 250(4):514-26. PMID: 7542350.
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    283. Raeber AJ, Muramoto T, Kornberg TB, Prusiner SB. Expression and targeting of Syrian hamster prion protein induced by heat shock in transgenic Drosophila melanogaster. Mech Dev. 1995 Jun; 51(2-3):317-27. PMID: 7547477.
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    284. Prusiner SB. Molecular genetics and biophysics of prions. Uirusu. 1995 Jun; 45(1):5-42. PMID: 7571451.
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    285. Kazmirski SL, Alonso DO, Cohen FE, Prusiner SB, Daggett V. Theoretical studies of sequence effects on the conformational properties of a fragment of the prion protein: implications for scrapie formation. Chem Biol. 1995 May; 2(5):305-15. PMID: 9383432.
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    286. Nguyen J, Baldwin MA, Cohen FE, Prusiner SB. Prion protein peptides induce alpha-helix to beta-sheet conformational transitions. Biochemistry. 1995 Apr 04; 34(13):4186-92. PMID: 7703230.
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    287. Taraboulos A, Scott M, Semenov A, Avrahami D, Laszlo L, Prusiner SB, Avraham D. Cholesterol depletion and modification of COOH-terminal targeting sequence of the prion protein inhibit formation of the scrapie isoform. J Cell Biol. 1995 Apr; 129(1):121-32. PMID: 7698979; PMCID: PMC2120366.
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    292. Prusiner SB. The prion diseases. Sci Am. 1995 Jan; 272(1):48-51, 54-7. PMID: 7824915.
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    294. Jefferys JG, Empson RM, Whittington MA, Prusiner SB. Scrapie infection of transgenic mice leads to network and intrinsic dysfunction of cortical and hippocampal neurones. Neurobiol Dis. 1994 Nov; 1(1-2):25-30. PMID: 9216983.
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    296. Hsiao KK, Groth D, Scott M, Yang SL, Serban H, Rapp D, Foster D, Torchia M, Dearmond SJ, Prusiner SB. Serial transmission in rodents of neurodegeneration from transgenic mice expressing mutant prion protein. Proc Natl Acad Sci U S A. 1994 Sep 13; 91(19):9126-30. PMID: 7916462; PMCID: PMC44760.
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    300. De Fea KA, Nakahara DH, Calayag MC, Yost CS, Mirels LF, Prusiner SB, Lingappa VR. Determinants of carboxyl-terminal domain translocation during prion protein biogenesis. J Biol Chem. 1994 Jun 17; 269(24):16810-20. PMID: 7911469.
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    301. Carlson GA, Ebeling C, Yang SL, Telling G, Torchia M, Groth D, Westaway D, DeArmond SJ, Prusiner SB. Prion isolate specified allotypic interactions between the cellular and scrapie prion proteins in congenic and transgenic mice. Proc Natl Acad Sci U S A. 1994 Jun 07; 91(12):5690-4. PMID: 7911243; PMCID: PMC44062.
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    304. Westaway D, Zuliani V, Cooper CM, Da Costa M, Neuman S, Jenny AL, Detwiler L, Prusiner SB. Homozygosity for prion protein alleles encoding glutamine-171 renders sheep susceptible to natural scrapie. Genes Dev. 1994 Apr 15; 8(8):959-69. PMID: 7926780.
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    305. Prusiner SB, Hsiao KK. Human prion diseases. Ann Neurol. 1994 Apr; 35(4):385-95. PMID: 8154865.
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    307. Gabizon R, Rosenman H, Meiner Z, Kahana I, Kahana E, Shugart Y, Ott J, Prusiner SB. Mutation in codon 200 and polymorphism in codon 129 of the prion protein gene in Libyan Jews with Creutzfeldt-Jakob disease. Philos Trans R Soc Lond B Biol Sci. 1994 Mar 29; 343(1306):385-90. PMID: 7913755.
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    308. DeArmond SJ, Yang SL, Cayetano-Canlas J, Groth D, Prusiner SB. The neuropathological phenotype in transgenic mice expressing different prion protein constructs. Philos Trans R Soc Lond B Biol Sci. 1994 Mar 29; 343(1306):415-23. PMID: 7913760.
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    309. Kellings K, Prusiner SB, Riesner D. Nucleic acids in prion preparations: unspecific background or essential component? Philos Trans R Soc Lond B Biol Sci. 1994 Mar 29; 343(1306):425-30. PMID: 7913761.
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    312. Gomi H, Ikeda T, Kunieda T, Itohara S, Prusiner SB, Yamanouchi K. Prion protein (PrP) is not involved in the pathogenesis of spongiform encephalopathy in zitter rats. Neurosci Lett. 1994 Jan 31; 166(2):171-4. PMID: 7909925.
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    313. Westaway D, DeArmond SJ, Cayetano-Canlas J, Groth D, Foster D, Yang SL, Torchia M, Carlson GA, Prusiner SB. Degeneration of skeletal muscle, peripheral nerves, and the central nervous system in transgenic mice overexpressing wild-type prion proteins. Cell. 1994 Jan 14; 76(1):117-29. PMID: 8287472.
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    314. Prusiner SB. A national strategy for development of effective methods for the prevention and treatment of Alzheimer's disease and related neurodegenerative disorders. Neurobiol Aging. 1994; 15 Suppl 2:S29-32. PMID: 7700455.
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    317. Fink JK, Peacock ML, Warren JT, Roses AD, Prusiner SB. Detecting prion protein gene mutations by denaturing gradient gel electrophoresis. Hum Mutat. 1994; 4(1):42-50. PMID: 7951257.
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    320. DeArmond SJ, Prusiner SB. The neurochemistry of prion diseases. J Neurochem. 1993 Nov; 61(5):1589-601. PMID: 7901326.
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    321. Prusiner SB. Genetic and infectious prion diseases. Arch Neurol. 1993 Nov; 50(11):1129-53. PMID: 8105771.
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    322. Gabizon R, Rosenmann H, Meiner Z, Kahana I, Kahana E, Shugart Y, Ott J, Prusiner SB. Mutation and polymorphism of the prion protein gene in Libyan Jews with Creutzfeldt-Jakob disease (CJD). Am J Hum Genet. 1993 Oct; 53(4):828-35. PMID: 8105682; PMCID: PMC1682379.
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    324. Borchelt DR, Rogers M, Stahl N, Telling G, Prusiner SB. Release of the cellular prion protein from cultured cells after loss of its glycoinositol phospholipid anchor. Glycobiology. 1993 Aug; 3(4):319-29. PMID: 7691278.
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    325. DeArmond SJ, Yang SL, Lee A, Bowler R, Taraboulos A, Groth D, Prusiner SB. Three scrapie prion isolates exhibit different accumulation patterns of the prion protein scrapie isoform. Proc Natl Acad Sci U S A. 1993 Jul 15; 90(14):6449-53. PMID: 8101989; PMCID: PMC46949.
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    327. Prusiner SB. Biology of prion diseases. J Acquir Immune Defic Syndr. 1993 Jun; 6(6):663-5. PMID: 8496798.
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    328. Rogers M, Yehiely F, Scott M, Prusiner SB. Conversion of truncated and elongated prion proteins into the scrapie isoform in cultured cells. Proc Natl Acad Sci U S A. 1993 Apr 15; 90(8):3182-6. PMID: 8475059; PMCID: PMC46263.
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    330. Carlson GA, Ebeling C, Torchia M, Westaway D, Prusiner SB. Delimiting the location of the scrapie prion incubation time gene on chromosome 2 of the mouse. Genetics. 1993 Apr; 133(4):979-88. PMID: 8462855; PMCID: PMC1205414.
    331. Stahl N, Baldwin MA, Teplow DB, Hood L, Gibson BW, Burlingame AL, Prusiner SB. Structural studies of the scrapie prion protein using mass spectrometry and amino acid sequencing. Biochemistry. 1993 Mar 02; 32(8):1991-2002. PMID: 8448158.
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    332. Prusiner SB, Füzi M, Scott M, Serban D, Serban H, Taraboulos A, Gabriel JM, Wells GA, Wilesmith JW, Bradley R. Immunologic and molecular biologic studies of prion proteins in bovine spongiform encephalopathy. J Infect Dis. 1993 Mar; 167(3):602-13. PMID: 8440932.
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    334. Gasset M, Baldwin MA, Fletterick RJ, Prusiner SB. Perturbation of the secondary structure of the scrapie prion protein under conditions that alter infectivity. Proc Natl Acad Sci U S A. 1993 Jan 01; 90(1):1-5. PMID: 8419912; PMCID: PMC45587.
    335. Riesner D, Kellings K, Wiese U, Wulfert M, Mirenda C, Prusiner SB. Prions and nucleic acids: search for "residual" nucleic acids and screening for mutations in the PrP-gene. Dev Biol Stand. 1993; 80:173-81. PMID: 8270107.
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    336. Prusiner SB. Prion encephalopathies of animals and humans. Dev Biol Stand. 1993; 80:31-44. PMID: 8270114.
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    337. Kellings K, Meyer N, Mirenda C, Prusiner SB, Riesner D. Analysis of nucleic acids in purified scrapie prion preparations. Arch Virol Suppl. 1993; 7:215-25. PMID: 8219805.
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    340. Giaccone G, Verga L, Bugiani O, Frangione B, Serban D, Prusiner S, Farlow MR, Ghetti B, Tagliavini F. Prion protein preamyloid and amyloid deposits in Gerstmann-Sträussler-Scheinker disease, Indiana kindred. Proc Natl Acad Sci U S A. 1992 Oct 01; 89(19):9349-53. PMID: 1357663; PMCID: PMC50124.
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    342. Kretzschmar HA, Neumann M, Riethmüller G, Prusiner S. Molecular cloning of a mink prion protein gene. J Gen Virol. 1992 Oct; 73 ( Pt 10):2757-61. PMID: 1383401.
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    343. Pan KM, Stahl N, Prusiner S. Purification and properties of the cellular prion protein from Syrian hamster brain. Protein Sci. 1992 Oct; 1(10):1343-52. PMID: 1363897; PMCID: PMC2142104.
    344. Gabriel JM, Oesch B, Kretzschmar H, Scott M, Prusiner S. Molecular cloning of a candidate chicken prion protein. Proc Natl Acad Sci U S A. 1992 Oct 01; 89(19):9097-101. PMID: 1409608; PMCID: PMC50072.
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    346. Taraboulos A, Jendroska K, Serban D, Yang SL, DeArmond SJ, Prusiner S. Regional mapping of prion proteins in brain. Proc Natl Acad Sci U S A. 1992 Aug 15; 89(16):7620-4. PMID: 1354357; PMCID: PMC49762.
    347. Borchelt DR, Taraboulos A, Prusiner S. Evidence for synthesis of scrapie prion proteins in the endocytic pathway. J Biol Chem. 1992 Aug 15; 267(23):16188-99. PMID: 1353761.
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    348. Scott MR, Köhler R, Foster D, Prusiner S. Chimeric prion protein expression in cultured cells and transgenic mice. Protein Sci. 1992 Aug; 1(8):986-97. PMID: 1338978; PMCID: PMC2142161.
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    350. Meiner Z, Halimi M, Polakiewicz RD, Prusiner S, Gabizon R. Presence of prion protein in peripheral tissues of Libyan Jews with Creutzfeldt-Jakob disease. Neurology. 1992 Jul; 42(7):1355-60. PMID: 1352391.
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    351. Hecker R, Taraboulos A, Scott M, Pan KM, Yang SL, Torchia M, Jendroska K, DeArmond SJ, Prusiner S. Replication of distinct scrapie prion isolates is region specific in brains of transgenic mice and hamsters. Genes Dev. 1992 Jul; 6(7):1213-28. PMID: 1628828.
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    352. Stahl N, Baldwin MA, Hecker R, Pan KM, Burlingame AL, Prusiner SB. Glycosylinositol phospholipid anchors of the scrapie and cellular prion proteins contain sialic acid. Biochemistry. 1992 Jun 02; 31(21):5043-53. PMID: 1350920.
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    353. Büeler H, Fischer M, Lang Y, Bluethmann H, Lipp HP, DeArmond SJ, Prusiner S, Aguet M, Weissmann C. Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein. Nature. 1992 Apr 16; 356(6370):577-82. PMID: 1373228.
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    354. Hsiao K, Dlouhy SR, Farlow MR, Cass C, Da Costa M, Conneally PM, Hodes ME, Ghetti B, Prusiner S. Mutant prion proteins in Gerstmann-Sträussler-Scheinker disease with neurofibrillary tangles. Nat Genet. 1992 Apr; 1(1):68-71. PMID: 1363810.
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    355. Kellings K, Meyer N, Mirenda C, Prusiner S, Riesner D. Further analysis of nucleic acids in purified scrapie prion preparations by improved return refocusing gel electrophoresis. J Gen Virol. 1992 Apr; 73 ( Pt 4):1025-9. PMID: 1353106.
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    356. Dlouhy SR, Hsiao K, Farlow MR, Foroud T, Conneally PM, Johnson P, Prusiner S, Hodes ME, Ghetti B. Linkage of the Indiana kindred of Gerstmann-Sträussler-Scheinker disease to the prion protein gene. Nat Genet. 1992 Apr; 1(1):64-7. PMID: 1363809.
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    357. Kretzschmar HA, Kufer P, Riethmüller G, DeArmond S, Prusiner SB, Schiffer D. Prion protein mutation at codon 102 in an Italian family with Gerstmann-Sträussler-Scheinker syndrome. Neurology. 1992 Apr; 42(4):809-10. PMID: 1348851.
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    358. Prusiner S. Molecular biology and genetics of neurodegenerative diseases caused by prions. Adv Virus Res. 1992; 41:241-80. PMID: 1575084.
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    359. McKinley MP, Taraboulos A, Kenaga L, Serban D, Stieber A, DeArmond SJ, Prusiner S, Gonatas N. Ultrastructural localization of scrapie prion proteins in cytoplasmic vesicles of infected cultured cells. Lab Invest. 1991 Dec; 65(6):622-30. PMID: 1684401.
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    360. Rogers M, Serban D, Gyuris T, Scott M, Torchia T, Prusiner S. Epitope mapping of the Syrian hamster prion protein utilizing chimeric and mutant genes in a vaccinia virus expression system. J Immunol. 1991 Nov 15; 147(10):3568-74. PMID: 1719082.
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    361. Stahl N, Prusiner S. Prions and prion proteins. FASEB J. 1991 Oct; 5(13):2799-807. PMID: 1916104.
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    362. Jendroska K, Heinzel FP, Torchia M, Stowring L, Kretzschmar HA, Kon A, Stern A, Prusiner S, DeArmond SJ. Proteinase-resistant prion protein accumulation in Syrian hamster brain correlates with regional pathology and scrapie infectivity. Neurology. 1991 Sep; 41(9):1482-90. PMID: 1679911.
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    363. Stahl N, Baldwin MA, Prusiner S. Electrospray mass spectrometry of the glycosylinositol phospholipid of the scrapie prion protein. Cell Biol Int Rep. 1991 Sep; 15(9):853-62. PMID: 1686992.
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    364. Prusiner S, DeArmond SJ. Molecular biology and pathology of scrapie and the prion diseases of humans. Brain Pathol. 1991 Jul; 1(4):297-310. PMID: 1669719.
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    365. Prusiner S. Molecular biology of prion diseases. Science. 1991 Jun 14; 252(5012):1515-22. PMID: 1675487.
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    366. Hsiao KK, Cass C, Schellenberg GD, Bird T, Devine-Gage E, Wisniewski H, Prusiner S. A prion protein variant in a family with the telencephalic form of Gerstmann-Sträussler-Scheinker syndrome. Neurology. 1991 May; 41(5):681-4. PMID: 1674116.
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    367. Prusiner S, Westaway D. Infectious and genetic manifestations of prion diseases. Mol Plant Microbe Interact. 1991 May-Jun; 4(3):226-33. PMID: 1932814.
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    368. Hsiao K, Meiner Z, Kahana E, Cass C, Kahana I, Avrahami D, Scarlato G, Abramsky O, Prusiner S, Gabizon R. Mutation of the prion protein in Libyan Jews with Creutzfeldt-Jakob disease. N Engl J Med. 1991 Apr 18; 324(16):1091-7. PMID: 2008182.
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    369. Prusiner S, Torchia M, Westaway D. Molecular biology and genetics of prions--implications for sheep scrapie, "mad cows" and the BSE epidemic. Historical background. Cornell Vet. 1991 Apr; 81(2):85-101. PMID: 2029844.
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    370. Tagliavini F, Prelli F, Ghiso J, Bugiani O, Serban D, Prusiner S, Farlow MR, Ghetti B, Frangione B. Amyloid protein of Gerstmann-Sträussler-Scheinker disease (Indiana kindred) is an 11 kd fragment of prion protein with an N-terminal glycine at codon 58. EMBO J. 1991 Mar; 10(3):513-9. PMID: 1672107; PMCID: PMC452678.
    371. McKinley MP, Meyer RK, Kenaga L, Rahbar F, Cotter R, Serban A, Prusiner S. Scrapie prion rod formation in vitro requires both detergent extraction and limited proteolysis. J Virol. 1991 Mar; 65(3):1340-51. PMID: 1704926; PMCID: PMC239910.
    372. Carlson GA, Hsiao K, Oesch B, Westaway D, Prusiner S. Genetics of prion infections. Trends Genet. 1991 Feb; 7(2):61-5. PMID: 1903568.
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    373. Prusiner S. Novel properties and biology of scrapie prions. Curr Top Microbiol Immunol. 1991; 172:233-57. PMID: 1687382.
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    374. McKinley MP, Prusiner S. Ultrastructural studies of prions. Curr Top Microbiol Immunol. 1991; 172:75-91. PMID: 1725771.
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    375. Prusiner S. Molecular biology and transgenetics of prion diseases. Crit Rev Biochem Mol Biol. 1991; 26(5-6):397-438. PMID: 1684745.
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    376. Prusiner SB. Prion biology and diseases. Harvey Lect. 1991-1992; 87:85-114. PMID: 1670551.
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    377. Hsiao K, Prusiner S. Molecular genetics and transgenic model of Gertsmann-Sträussler-Scheinker disease. Alzheimer Dis Assoc Disord. 1991; 5(3):155-62. PMID: 1685324.
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    378. Meyer N, Rosenbaum V, Schmidt B, Gilles K, Mirenda C, Groth D, Prusiner S, Riesner D. Search for a putative scrapie genome in purified prion fractions reveals a paucity of nucleic acids. J Gen Virol. 1991 Jan; 72 ( Pt 1):37-49. PMID: 1899270.
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    379. Prusiner S. Molecular biology of prions causing infectious and genetic encephalopathies of humans as well as scrapie of sheep and BSE of cattle. Dev Biol Stand. 1991; 75:55-74. PMID: 1686599.
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    380. Epstein CJ, Foster DB, DeArmond SJ, Prusiner S. Acceleration of scrapie in trisomy 16----diploid aggregation chimeras. Ann Neurol. 1991 Jan; 29(1):95-7. PMID: 1996884.
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    381. Oesch B, Westaway D, Prusiner S. Prion protein genes: evolutionary and functional aspects. Curr Top Microbiol Immunol. 1991; 172:109-24. PMID: 1687379.
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    382. Hsiao K, Scott M, Foster D, DeArmond SJ, Groth D, Serban H, Prusiner S. Spontaneous neurodegeneration in transgenic mice with prion protein codon 101 proline----leucine substitution. Ann N Y Acad Sci. 1991; 640:166-70. PMID: 1685642.
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    383. Hsiao KK, Scott M, Foster D, Groth DF, DeArmond SJ, Prusiner SB. Spontaneous neurodegeneration in transgenic mice with mutant prion protein. Science. 1990 Dec 14; 250(4987):1587-90. PMID: 1980379.
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    384. Hsiao K, Prusiner S. Inherited human prion diseases. Neurology. 1990 Dec; 40(12):1820-7. PMID: 2247227.
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    385. Prusiner SB, Scott M, Foster D, Pan KM, Groth D, Mirenda C, Torchia M, Yang SL, Serban D, Carlson GA. Transgenetic studies implicate interactions between homologous PrP isoforms in scrapie prion replication. Cell. 1990 Nov 16; 63(4):673-86. PMID: 1977523.
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    386. Baldwin MA, Stahl N, Reinders LG, Gibson BW, Prusiner SB, Burlingame AL. Permethylation and tandem mass spectrometry of oligosaccharides having free hexosamine: analysis of the glycoinositol phospholipid anchor glycan from the scrapie prion protein. Anal Biochem. 1990 Nov 15; 191(1):174-82. PMID: 1981823.
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    387. Snow AD, Wight TN, Nochlin D, Koike Y, Kimata K, DeArmond SJ, Prusiner S. Immunolocalization of heparan sulfate proteoglycans to the prion protein amyloid plaques of Gerstmann-Straussler syndrome, Creutzfeldt-Jakob disease and scrapie. Lab Invest. 1990 Nov; 63(5):601-11. PMID: 1977959.
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    388. Taraboulos A, Rogers M, Borchelt DR, McKinley MP, Scott M, Serban D, Prusiner S. Acquisition of protease resistance by prion proteins in scrapie-infected cells does not require asparagine-linked glycosylation. Proc Natl Acad Sci U S A. 1990 Nov; 87(21):8262-6. PMID: 1978322; PMCID: PMC54935.
    389. Prusiner SB. Novel structure and genetics of prions causing neurodegeneration in humans and animals. Biologicals. 1990 Oct; 18(4):247-62. PMID: 1981006.
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    390. Stahl N, Baldwin MA, Burlingame AL, Prusiner SB. Identification of glycoinositol phospholipid linked and truncated forms of the scrapie prion protein. Biochemistry. 1990 Sep 25; 29(38):8879-84. PMID: 1980209.
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    391. Rogers M, Taraboulos A, Scott M, Groth D, Prusiner S. Intracellular accumulation of the cellular prion protein after mutagenesis of its Asn-linked glycosylation sites. Glycobiology. 1990 Sep; 1(1):101-9. PMID: 1983782.
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    392. Westaway D, Prusiner S. Link between scrapie and BSE? Nature. 1990 Jul 12; 346(6280):113. PMID: 2366871.
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    393. Oesch B, Teplow DB, Stahl N, Serban D, Hood LE, Prusiner S. Identification of cellular proteins binding to the scrapie prion protein. Biochemistry. 1990 Jun 19; 29(24):5848-55. PMID: 1974464.
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    394. Stahl N, Borchelt DR, Prusiner S. Differential release of cellular and scrapie prion proteins from cellular membranes by phosphatidylinositol-specific phospholipase C. Biochemistry. 1990 Jun 05; 29(22):5405-12. PMID: 1974460.
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    395. Taraboulos A, Serban D, Prusiner S. Scrapie prion proteins accumulate in the cytoplasm of persistently infected cultured cells. J Cell Biol. 1990 Jun; 110(6):2117-32. PMID: 1693623; PMCID: PMC2116143.
    396. Lopez CD, Yost CS, Prusiner S, Myers RM, Lingappa VR. Unusual topogenic sequence directs prion protein biogenesis. Science. 1990 Apr 13; 248(4952):226-9. PMID: 1970195.
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    397. Boylan KB, Takahashi N, Paty DW, Sadovnick AD, Diamond M, Hood LE, Prusiner S. DNA length polymorphism 5' to the myelin basic protein gene is associated with multiple sclerosis. Ann Neurol. 1990 Mar; 27(3):291-7. PMID: 1691612.
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    398. Borchelt DR, Scott M, Taraboulos A, Stahl N, Prusiner S. Scrapie and cellular prion proteins differ in their kinetics of synthesis and topology in cultured cells. J Cell Biol. 1990 Mar; 110(3):743-52. PMID: 1968466; PMCID: PMC2116048.
    399. Lowenstein DH, Butler DA, Westaway D, McKinley MP, DeArmond SJ, Prusiner S. Three hamster species with different scrapie incubation times and neuropathological features encode distinct prion proteins. Mol Cell Biol. 1990 Mar; 10(3):1153-63. PMID: 2406562; PMCID: PMC360985.
    400. Gabizon R, Prusiner S. Prion liposomes. Biochem J. 1990 Feb 15; 266(1):1-14. PMID: 1968741; PMCID: PMC1131089.
    401. Yost CS, Lopez CD, Prusiner S, Myers RM, Lingappa VR. Non-hydrophobic extracytoplasmic determinant of stop transfer in the prion protein. Nature. 1990 Feb 15; 343(6259):669-72. PMID: 1968226.
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    402. McKinley MP, Longo FM, Valletta JS, Rahbar F, Neve RL, Prusiner S, Mobley WC. Nerve growth factor induces gene expression of the prion protein and beta-amyloid protein precursor in the developing hamster central nervous system. Prog Brain Res. 1990; 86:227-38. PMID: 1982367.
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    403. Serban D, Taraboulos A, DeArmond SJ, Prusiner S. Rapid detection of Creutzfeldt-Jakob disease and scrapie prion proteins. Neurology. 1990 Jan; 40(1):110-7. PMID: 1967489.
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    404. Prusiner S, DeArmond SJ. Prion diseases of the central nervous system. Monogr Pathol. 1990; (32):86-122. PMID: 2192281.
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    405. Boylan KB, Ayres TM, Popko B, Takahashi N, Hood LE, Prusiner S. Repetitive DNA (TGGA)n 5' to the human myelin basic protein gene: a new form of oligonucleotide repetitive sequence showing length polymorphism. Genomics. 1990 Jan; 6(1):16-22. PMID: 1689270.
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    406. Scott M, Foster D, Mirenda C, Serban D, Coufal F, Wälchli M, Torchia M, Groth D, Carlson G, DeArmond SJ, Westaway D, Prusiner S. Transgenic mice expressing hamster prion protein produce species-specific scrapie infectivity and amyloid plaques. Cell. 1989 Dec 01; 59(5):847-57. PMID: 2574076.
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    407. Endo T, Groth D, Prusiner S, Kobata A. Diversity of oligosaccharide structures linked to asparagines of the scrapie prion protein. Biochemistry. 1989 Oct 17; 28(21):8380-8. PMID: 2574992.
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    408. McKinley MP, DeArmond SJ, Torchia M, Mobley WC, Prusiner S. Acceleration of scrapie in neonatal Syrian hamsters. Neurology. 1989 Oct; 39(10):1319-24. PMID: 2507957.
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    409. Carlson GA, Westaway D, DeArmond SJ, Peterson-Torchia M, Prusiner S. Primary structure of prion protein may modify scrapie isolate properties. Proc Natl Acad Sci U S A. 1989 Oct; 86(19):7475-9. PMID: 2798418; PMCID: PMC298087.
    410. Westaway D, Carlson GA, Prusiner S. Unraveling prion diseases through molecular genetics. Trends Neurosci. 1989 Jun; 12(6):221-7. PMID: 2473558.
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    411. Prusiner S. Creutzfeldt-Jakob disease and scrapie prions. Alzheimer Dis Assoc Disord. 1989 Spring-Summer; 3(1-2):52-78. PMID: 2568118.
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    412. Hsiao K, Baker HF, Crow TJ, Poulter M, Owen F, Terwilliger JD, Westaway D, Ott J, Prusiner S. Linkage of a prion protein missense variant to Gerstmann-Sträussler syndrome. Nature. 1989 Mar 23; 338(6213):342-5. PMID: 2564168.
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    413. Owen F, Poulter M, Lofthouse R, Collinge J, Crow TJ, Risby D, Baker HF, Ridley RM, Hsiao K, Prusiner S. Insertion in prion protein gene in familial Creutzfeldt-Jakob disease. Lancet. 1989 Jan 07; 1(8628):51-2. PMID: 2563037.
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    414. Gabizon R, McKinley MP, Groth D, Westaway D, DeArmond SJ, Carlson GA, Prusiner S. Immunoaffinity purification and neutralization of scrapie prions. Prog Clin Biol Res. 1989; 317:583-600. PMID: 2574871.
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    415. Snow AD, Kisilevsky R, Willmer J, Prusiner S, DeArmond SJ. Sulfated glycosaminoglycans in amyloid plaques of prion diseases. Acta Neuropathol. 1989; 77(4):337-42. PMID: 2523631.
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    416. De Armond SJ, Gonzales M, Mobley WC, Kon AA, Stern A, Prusiner H, Prusiner S. PrPSc in scrapie-infected hamster brain is spatially and temporally related to histopathology and infectivity titer. Prog Clin Biol Res. 1989; 317:601-18. PMID: 2574872.
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    417. Prusiner S. Scrapie prions. Annu Rev Microbiol. 1989; 43:345-74. PMID: 2572197.
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    418. Mobley WC, Neve RL, Prusiner S, McKinley MP. Nerve growth factor increases mRNA levels for the prion protein and the beta-amyloid protein precursor in developing hamster brain. Proc Natl Acad Sci U S A. 1988 Dec; 85(24):9811-5. PMID: 2904679; PMCID: PMC282871.
    419. Carlson GA, Goodman PA, Lovett M, Taylor BA, Marshall ST, Peterson-Torchia M, Westaway D, Prusiner S. Genetics and polymorphism of the mouse prion gene complex: control of scrapie incubation time. Mol Cell Biol. 1988 Dec; 8(12):5528-40. PMID: 3149717; PMCID: PMC365657.
    420. Roberts GW, Lofthouse R, Allsop D, Landon M, Kidd M, Prusiner S, Crow TJ. CNS amyloid proteins in neurodegenerative diseases. Neurology. 1988 Oct; 38(10):1534-40. PMID: 2901696.
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    421. Turk E, Teplow DB, Hood LE, Prusiner S. Purification and properties of the cellular and scrapie hamster prion proteins. Eur J Biochem. 1988 Sep 01; 176(1):21-30. PMID: 3138115.
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    422. Gabizon R, McKinley MP, Groth D, Prusiner S. Immunoaffinity purification and neutralization of scrapie prion infectivity. Proc Natl Acad Sci U S A. 1988 Sep; 85(18):6617-21. PMID: 3137571; PMCID: PMC282028.
    423. Bellinger-Kawahara CG, Kempner E, Groth D, Gabizon R, Prusiner S. Scrapie prion liposomes and rods exhibit target sizes of 55,000 Da. Virology. 1988 Jun; 164(2):537-41. PMID: 3130718.
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    424. Butler DA, Scott MR, Bockman JM, Borchelt DR, Taraboulos A, Hsiao KK, Kingsbury DT, Prusiner SB. Scrapie-infected murine neuroblastoma cells produce protease-resistant prion proteins. J Virol. 1988 May; 62(5):1558-64. PMID: 3282080; PMCID: PMC253182.
    425. Gabizon R, McKinley MP, Groth DF, Kenaga L, Prusiner SB. Properties of scrapie prion protein liposomes. J Biol Chem. 1988 Apr 05; 263(10):4950-5. PMID: 3350818.
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    426. Scott MR, Butler DA, Bredesen DE, Wälchli M, Hsiao KK, Prusiner S. Prion protein gene expression in cultured cells. Protein Eng. 1988 Apr; 2(1):69-76. PMID: 2908139.
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    427. Barry RA, Vincent MT, Kent SB, Hood LE, Prusiner S. Characterization of prion proteins with monospecific antisera to synthetic peptides. J Immunol. 1988 Feb 15; 140(4):1188-93. PMID: 3125249.
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    428. Prusiner S, Stahl N, DeArmond SJ. Novel mechanisms of degeneration of the central nervous system--prion structure and biology. Ciba Found Symp. 1988; 135:239-60. PMID: 2900720.
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    429. Carlson GA, Westaway D, Goodman PA, Peterson M, Marshall ST, Prusiner S. Genetic control of prion incubation period in mice. Ciba Found Symp. 1988; 135:84-99. PMID: 2900721.
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    430. McKinley MP, Lingappa VR, Prusiner S. Developmental regulation of prion protein mRNA in brain. Ciba Found Symp. 1988; 135:101-16. PMID: 2900716.
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    431. Gabizon R, McKinley MP, Prusiner S. Properties of scrapie prion proteins in liposomes and amyloid rods. Ciba Found Symp. 1988; 135:182-96. PMID: 2900719.
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    432. Prusiner S. Molecular structure, biology, and genetics of prions. Adv Virus Res. 1988; 35:83-136. PMID: 2906782.
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    433. Oesch B, Groth DF, Prusiner S, Weissmann C. Search for a scrapie-specific nucleic acid: a progress report. Ciba Found Symp. 1988; 135:209-23. PMID: 3137001.
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    434. Prusiner SB. Prions and neurodegenerative diseases. N Engl J Med. 1987 Dec 17; 317(25):1571-81. PMID: 3317055.
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    435. Hay B, Prusiner S, Lingappa VR. Evidence for a secretory form of the cellular prion protein. Biochemistry. 1987 Dec 15; 26(25):8110-5. PMID: 3126796.
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    436. Wiley CA, Burrola PG, Buchmeier MJ, Wooddell MK, Barry RA, Prusiner S, Lampert PW. Immuno-gold localization of prion filaments in scrapie-infected hamster brains. Lab Invest. 1987 Dec; 57(6):646-56. PMID: 2891874.
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    437. Braun MJ, Gonda MA, George DG, Bazan JF, Fletterick RJ, Prusiner S. The burden of proof in linking AIDS to scrapie. Nature. 1987 Dec 10-16; 330(6148):525-6. PMID: 2891035.
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    438. Westaway D, Goodman PA, Mirenda CA, McKinley MP, Carlson GA, Prusiner S. Distinct prion proteins in short and long scrapie incubation period mice. Cell. 1987 Nov 20; 51(4):651-62. PMID: 2890436.
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    439. Stahl N, Borchelt DR, Hsiao K, Prusiner S. Scrapie prion protein contains a phosphatidylinositol glycolipid. Cell. 1987 Oct 23; 51(2):229-40. PMID: 2444340.
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    440. Bellinger-Kawahara C, Diener TO, McKinley MP, Groth DF, Smith DR, Prusiner S. Purified scrapie prions resist inactivation by procedures that hydrolyze, modify, or shear nucleic acids. Virology. 1987 Sep; 160(1):271-4. PMID: 3114950.
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    441. Kitamoto T, Ogomori K, Tateishi J, Prusiner S. Formic acid pretreatment enhances immunostaining of cerebral and systemic amyloids. Lab Invest. 1987 Aug; 57(2):230-6. PMID: 2441141.
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    442. DeArmond SJ, Mobley WC, DeMott DL, Barry RA, Beckstead JH, Prusiner S. Changes in the localization of brain prion proteins during scrapie infection. Neurology. 1987 Aug; 37(8):1271-80. PMID: 3112607.
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    443. Hogan RN, Baringer JR, Prusiner SB. Scrapie infection diminishes spines and increases varicosities of dendrites in hamsters: a quantitative Golgi analysis. J Neuropathol Exp Neurol. 1987 Jul; 46(4):461-73. PMID: 3598605.
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    444. Gabizon R, McKinley MP, Prusiner S. Purified prion proteins and scrapie infectivity copartition into liposomes. Proc Natl Acad Sci U S A. 1987 Jun; 84(12):4017-21. PMID: 3108886; PMCID: PMC305012.
    445. Bockman JM, Prusiner SB, Tateishi J, Kingsbury DT. Immunoblotting of Creutzfeldt-Jakob disease prion proteins: host species-specific epitopes. Ann Neurol. 1987 Jun; 21(6):589-95. PMID: 3300520.
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    446. Boylan KB, Takahashi N, Diamond M, Hood LE, Prusiner S. DNA length polymorphism located 5' to the human myelin basic protein gene. Am J Hum Genet. 1987 May; 40(5):387-400. PMID: 2437796; PMCID: PMC1684138.
    447. McKinley MP, Hay B, Lingappa VR, Lieberburg I, Prusiner SB. Developmental expression of prion protein gene in brain. Dev Biol. 1987 May; 121(1):105-10. PMID: 3569656.
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    448. Prusiner S, DeArmond SJ. Prions causing nervous system degeneration. Lab Invest. 1987 Apr; 56(4):349-63. PMID: 2882063.
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    449. Prusiner SB. Prion diseases and central nervous system degeneration. Clin Res. 1987 Apr; 35(3):177-91. PMID: 3552382.
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    450. Bazan JF, Fletterick RJ, McKinley MP, Prusiner S. Predicted secondary structure and membrane topology of the scrapie prion protein. Protein Eng. 1987 Feb-Mar; 1(2):125-35. PMID: 2907134.
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    451. Hay B, Barry RA, Lieberburg I, Prusiner SB, Lingappa VR. Biogenesis and transmembrane orientation of the cellular isoform of the scrapie prion protein [published errratum appears in Mol Cell Biol 1987 May;7(5):2035]. Mol Cell Biol. 1987 Feb; 7(2):914-20. PMID: 3547085; PMCID: PMC365150.
    452. Fernando Bazan J, Fletterick RJ, Prusiner S. AIDS virus and scrapie protein genes. Nature. 1987 Feb 12-18; 325(6105):581. PMID: 3100963.
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    453. Bellinger-Kawahara C, Cleaver JE, Diener TO, Prusiner S. Purified scrapie prions resist inactivation by UV irradiation. J Virol. 1987 Jan; 61(1):159-66. PMID: 3097336; PMCID: PMC255227.
    454. Prusiner SB, Gabizon R, McKinley MP. On the biology of prions. Acta Neuropathol. 1987; 72(4):299-314. PMID: 3554880.
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    455. Prusiner SB. Prions causing degenerative neurological diseases. Annu Rev Med. 1987; 38:381-98. PMID: 3555303.
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    456. Prusiner SB. Prions are novel infectious pathogens causing scrapie and Creutzfeldt-Jakob disease. Bioessays. 1986 Dec; 5(6):281-6. PMID: 3551942.
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    457. Roberts GW, Lofthouse R, Brown R, Crow TJ, Barry RA, Prusiner SB. Prion-protein immunoreactivity in human transmissible dementias. N Engl J Med. 1986 Nov 06; 315(19):1231-3. PMID: 3531867.
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    458. Crook RB, Prusiner S. Vasoactive intestinal peptide stimulates cyclic AMP metabolism in choroid plexus epithelial cells. Brain Res. 1986 Oct 01; 384(1):138-44. PMID: 3024776.
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    459. Barry RA, Prusiner S. Monoclonal antibodies to the cellular and scrapie prion proteins. J Infect Dis. 1986 Sep; 154(3):518-21. PMID: 3090160.
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    460. Carlson GA, Kingsbury DT, Goodman PA, Coleman S, Marshall ST, DeArmond S, Westaway D, Prusiner S. Linkage of prion protein and scrapie incubation time genes. Cell. 1986 Aug 15; 46(4):503-11. PMID: 3015416.
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    461. Kretzschmar HA, Stowring LE, Westaway D, Stubblebine WH, Prusiner SB, Dearmond SJ. Molecular cloning of a human prion protein cDNA. DNA. 1986 Aug; 5(4):315-24. PMID: 3755672.
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    462. Kitamoto T, Tateishi J, Tashima T, Takeshita I, Barry RA, DeArmond SJ, Prusiner S. Amyloid plaques in Creutzfeldt-Jakob disease stain with prion protein antibodies. Ann Neurol. 1986 Aug; 20(2):204-8. PMID: 3092727.
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    463. Basler K, Oesch B, Scott M, Westaway D, Wälchli M, Groth DF, McKinley MP, Prusiner S, Weissmann C. Scrapie and cellular PrP isoforms are encoded by the same chromosomal gene. Cell. 1986 Aug 01; 46(3):417-28. PMID: 2873895.
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    464. McKinley MP, Braunfeld MB, Bellinger CG, Prusiner S. Molecular characteristics of prion rods purified from scrapie-infected hamster brains. J Infect Dis. 1986 Jul; 154(1):110-20. PMID: 2872252.
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    465. Barry RA, Kent SB, McKinley MP, Meyer RK, DeArmond SJ, Hood LE, Prusiner S. Scrapie and cellular prion proteins share polypeptide epitopes. J Infect Dis. 1986 May; 153(5):848-54. PMID: 2422294.
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    466. Meyer RK, McKinley MP, Bowman KA, Braunfeld MB, Barry RA, Prusiner S. Separation and properties of cellular and scrapie prion proteins. Proc Natl Acad Sci U S A. 1986 Apr; 83(8):2310-4. PMID: 3085093; PMCID: PMC323286.
    467. Westaway D, Prusiner S. Conservation of the cellular gene encoding the scrapie prion protein. Nucleic Acids Res. 1986 Mar 11; 14(5):2035-44. PMID: 2870469; PMCID: PMC339641.
    468. Crook RB, Farber MB, Prusiner S. H2 histamine receptors on the epithelial cells of choroid plexus. J Neurochem. 1986 Feb; 46(2):489-93. PMID: 3001227.
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    469. Kretzschmar HA, Prusiner S, Stowring LE, DeArmond SJ. Scrapie prion proteins are synthesized in neurons. Am J Pathol. 1986 Jan; 122(1):1-5. PMID: 3079955; PMCID: PMC1888142.
    470. Hogan RN, Bowman KA, Baringer JR, Prusiner S. Replication of scrapie prions in hamster eyes precedes retinal degeneration. Ophthalmic Res. 1986; 18(4):230-5. PMID: 3095759.
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    471. McKinley MP, Prusiner S. Biology and structure of scrapie prions. Int Rev Neurobiol. 1986; 28:1-57. PMID: 3100471.
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    472. Prusiner SB, Cochran SP, Alpers MP. Transmission of scrapie in hamsters. J Infect Dis. 1985 Nov; 152(5):971-8. PMID: 3930630.
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    473. Takahashi N, Roach A, Teplow DB, Prusiner S, Hood L. Cloning and characterization of the myelin basic protein gene from mouse: one gene can encode both 14 kd and 18.5 kd MBPs by alternate use of exons. Cell. 1985 Aug; 42(1):139-48. PMID: 2410136.
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    474. Monteiro ML, Swanson RA, Coppeto JR, Cuneo RA, DeArmond SJ, Prusiner SB. A microangiopathic syndrome of encephalopathy, hearing loss, and retinal arteriolar occlusions. Neurology. 1985 Aug; 35(8):1113-21. PMID: 4022345.
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    475. Barry RA, McKinley MP, Bendheim PE, Lewis GK, DeArmond SJ, Prusiner SB. Antibodies to the scrapie protein decorate prion rods. J Immunol. 1985 Jul; 135(1):603-13. PMID: 3923112.
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    476. DeArmond SJ, McKinley MP, Barry RA, Braunfeld MB, McColloch JR, Prusiner SB. Identification of prion amyloid filaments in scrapie-infected brain. Cell. 1985 May; 41(1):221-35. PMID: 3922627.
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    477. Bendheim PE, Bockman JM, McKinley MP, Kingsbury DT, Prusiner S. Scrapie and Creutzfeldt-Jakob disease prion proteins share physical properties and antigenic determinants. Proc Natl Acad Sci U S A. 1985 Feb; 82(4):997-1001. PMID: 2579394; PMCID: PMC397180.
    478. Bolton DC, Meyer RK, Prusiner SB. Scrapie PrP 27-30 is a sialoglycoprotein. J Virol. 1985 Feb; 53(2):596-606. PMID: 3918176; PMCID: PMC254675.
    479. Bockman JM, Kingsbury DT, McKinley MP, Bendheim PE, Prusiner SB. Creutzfeldt-Jakob disease prion proteins in human brains. N Engl J Med. 1985 Jan 10; 312(2):73-8. PMID: 3917302.
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    480. Prusiner SB, Barry RA, McKinley MP, Bellinger CG, Meyer RK, DeArmond SJ, Kingsbury DT. Scrapie and Creutzfeldt-Jakob disease prions. Microbiol Sci. 1985; 2(2):33-9. PMID: 3940147.
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    481. Prusiner SB, Kingsbury DT. Prions--infectious pathogens causing the spongiform encephalopathies. CRC Crit Rev Clin Neurobiol. 1985; 1(3):181-200. PMID: 3915974.
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    482. Prusiner S. Scrapie prions, brain amyloid, and senile dementia. Curr Top Cell Regul. 1985; 26:79-95. PMID: 2934227.
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    483. Bolton DC, McKinley MP, Prusiner SB. Molecular characteristics of the major scrapie prion protein. Biochemistry. 1984 Dec 04; 23(25):5898-906. PMID: 6395885.
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    484. Prusiner SB. Prions. Sci Am. 1984 Oct; 251(4):50-9. PMID: 6385236.
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    485. Friedland RP, Prusiner SB, Jagust WJ, Budinger TF, Davis RL. Bitemporal hypometabolism in Creutzfeldt-Jakob disease measured by positron emission tomography with [18F]-2-fluorodeoxyglucose. J Comput Assist Tomogr. 1984 Oct; 8(5):978-81. PMID: 6381559.
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    486. Prusiner SB, Groth DF, Bolton DC, Kent SB, Hood LE. Purification and structural studies of a major scrapie prion protein. Cell. 1984 Aug; 38(1):127-34. PMID: 6432339.
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    487. Bendheim PE, Barry RA, DeArmond SJ, Stites DP, Prusiner SB. Antibodies to a scrapie prion protein. Nature. 1984 Aug 2-8; 310(5976):418-21. PMID: 6431296.
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    488. Prusiner SB. Some speculations about prions, amyloid, and Alzheimer's disease. N Engl J Med. 1984 Mar 08; 310(10):661-3. PMID: 6363926.
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    489. Crook RB, Farber MB, Prusiner SB. Hormones and neurotransmitters control cyclic AMP metabolism in choroid plexus epithelial cells. J Neurochem. 1984 Feb; 42(2):340-50. PMID: 6198461.
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    490. Prusiner SB. Prions: novel infectious pathogens. Adv Virus Res. 1984; 29:1-56. PMID: 6241423.
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    491. Prusiner SB, McKinley MP, Bowman KA, Bolton DC, Bendheim PE, Groth DF, Glenner GG. Scrapie prions aggregate to form amyloid-like birefringent rods. Cell. 1983 Dec; 35(2 Pt 1):349-58. PMID: 6418385.
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    492. Hogan RN, Kingsbury DT, Baringer JR, Prusiner SB. Retinal degeneration in experimental Creutzfeldt-Jakob disease. Lab Invest. 1983 Dec; 49(6):708-15. PMID: 6361375.
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    493. McKinley MP, Bolton DC, Prusiner SB. A protease-resistant protein is a structural component of the scrapie prion. Cell. 1983 Nov; 35(1):57-62. PMID: 6414721.
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    494. Roach A, Boylan K, Horvath S, Prusiner SB, Hood LE. Characterization of cloned cDNA representing rat myelin basic protein: absence of expression in brain of shiverer mutant mice. Cell. 1983 Oct; 34(3):799-806. PMID: 6194889.
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    495. Baringer JR, Bowman KA, Prusiner SB. Replication of the scrapie agent in hamster brain precedes neuronal vacuolation. J Neuropathol Exp Neurol. 1983 Sep; 42(5):539-47. PMID: 6411868.
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    496. Kingsbury DT, Kasper KC, Stites DP, Watson JD, Hogan RN, Prusiner SB. Genetic control of scrapie and Creutzfeldt-Jakob disease in mice. J Immunol. 1983 Jul; 131(1):491-6. PMID: 6408182.
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    497. McKinley MP, Masiarz FR, Isaacs ST, Hearst JE, Prusiner SB. Resistance of the scrapie agent to inactivation by psoralens. Photochem Photobiol. 1983 May; 37(5):539-45. PMID: 6410423.
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    498. Bolton DC, McKinley MP, Prusiner SB. Identification of a protein that purifies with the scrapie prion. Science. 1982 Dec 24; 218(4579):1309-11. PMID: 6815801.
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    499. Prusiner SB, Bolton DC, Groth DF, Bowman KA, Cochran SP, McKinley MP. Further purification and characterization of scrapie prions. Biochemistry. 1982 Dec 21; 21(26):6942-50. PMID: 6818988.
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    500. Kasper KC, Stites DP, Bowman KA, Panitch H, Prusiner SB. Immunological studies of scrapie infection. J Neuroimmunol. 1982 Nov; 3(3):187-201. PMID: 6183292.
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    501. Diener TO, McKinley MP, Prusiner SB. Viroids and prions. Proc Natl Acad Sci U S A. 1982 Sep; 79(17):5220-4. PMID: 6813855; PMCID: PMC346867.
    502. Prusiner SB. Research on scrapie. Lancet. 1982 Aug 28; 2(8296):494-5. PMID: 6125659.
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    503. Prusiner SB, Gajdusek C, Alpers MP. Kuru with incubation periods exceeding two decades. Ann Neurol. 1982 Jul; 12(1):1-9. PMID: 7114816.
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    504. Prusiner SB. Novel proteinaceous infectious particles cause scrapie. Science. 1982 Apr 09; 216(4542):136-44. PMID: 6801762.
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    505. Prusiner SB, Cochran SP, Groth DF, Downey DE, Bowman KA, Martinez HM. Measurement of the scrapie agent using an incubation time interval assay. Ann Neurol. 1982 Apr; 11(4):353-8. PMID: 6808890.
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    506. McKinley MP, Masiarz FR, Prusiner SB. Reversible chemical modification of the scrapie agent. Science. 1981 Dec 11; 214(4526):1259-61. PMID: 6795721.
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    507. Prusiner SB, McKinley MP, Groth DF, Bowman KA, Mock NI, Cochran SP, Masiarz FR. Scrapie agent contains a hydrophobic protein. Proc Natl Acad Sci U S A. 1981 Nov; 78(11):6675-9. PMID: 6273882; PMCID: PMC349112.
    508. Crook RB, Kasagami H, Prusiner SB. Culture and characterization of epithelial cells from bovine choroid plexus. J Neurochem. 1981 Oct; 37(4):845-54. PMID: 6119356.
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    509. Mamelok RD, Macrae DR, Benet LZ, Prusiner SB. Membrane populations of bovine choroid plexus: separation by density gradient centrifugation in modified colloidal silica. J Neurochem. 1981 Sep; 37(3):768-74. PMID: 6115891.
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    510. Prusiner SB, Groth DF, McKinley MP, Cochran SP, Bowman KA, Kasper KC. Thiocyanate and hydroxyl ions inactivate the scrapie agent. Proc Natl Acad Sci U S A. 1981 Jul; 78(7):4606-10. PMID: 6794034; PMCID: PMC319842.
    511. Baringer JR, Prusiner SB, Wong JS. Scrapie-associated particles in postsynaptic processes. Further ultrastructural studies. J Neuropathol Exp Neurol. 1981 May; 40(3):281-8. PMID: 7194369.
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    512. Mamelok RD, Macrae DR, Hittelman K, Hoefer JP, Prusiner SB. Kinetics of D-glucose transport into renal membrane vesicles: measurements using a vacuum manifold apparatus. J Biochem Biophys Methods. 1981 Mar; 4(3-4):147-53. PMID: 7240643.
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    513. Prusiner SB. Disorders of glutamate metabolism and neurological dysfunction. Annu Rev Med. 1981; 32:521-42. PMID: 7013687.
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    514. Kasper KC, Bowman K, Stites DP, Prusiner SB. Toward development of assays for scrapie-specific antibodies. Adv Exp Med Biol. 1981; 134:401-13. PMID: 6261543.
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    515. Hogan RN, Baringer JR, Prusiner SB. Progressive retinal degeneration in scrapie-infected hamsters: a light and electron microscopic analysis. Lab Invest. 1981 Jan; 44(1):34-42. PMID: 6779055.
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    516. Prusiner SB, Cochran SP, Downey DE, Groth DF. Determination of scrapie agent titer from incubation period measurements in hamsters. Adv Exp Med Biol. 1981; 134:385-99. PMID: 7194570.
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    517. Hadlow WJ, Prusiner SB, Kennedy RC, Race RE. Brain tissue from persons dying of Creutzfeldt-Jakob disease causes scrapie-like encephalopathy in goats. Ann Neurol. 1980 Dec; 8(6):628-32. PMID: 7011169.
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    518. Prusiner SB, Groth DF, Cochran SP, McKinley MP, Masiarz FR. Gel electrophoresis and glass permeation chromatography of the hamster scrapie agent after enzymatic digestion and detergent extraction. Biochemistry. 1980 Oct 14; 19(21):4892-8. PMID: 6775698.
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    519. Prusiner SB, Groth DF, Cochran SP, Masiarz FR, McKinley MP, Martinez HM. Molecular properties, partial purification, and assay by incubation period measurements of the hamster scrapie agent. Biochemistry. 1980 Oct 14; 19(21):4883-91. PMID: 6775697.
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    520. Prusiner SB, Garfin DE, Cochran SP, McKinley MP, Groth DF, Hadlow WJ, Race RE, Eklund CM. Experimental scrapie in the mouse: electrophoretic and sedimentation properties of the partially purified agent. J Neurochem. 1980 Sep; 35(3):574-82. PMID: 6778963.
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    521. Chatigny MA, Prusiner SB. Biohazards of investigations on the transmissible spongiform encephalopathies. Rev Infect Dis. 1980 Sep-Oct; 2(5):713-24. PMID: 6302811.
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    522. Mamelok RD, Groth DF, Prusiner SB. Separation of membrane-bound gamma-glutamyl transpeptidase from brush border transport and enzyme activities. Biochemistry. 1980 May 27; 19(11):2367-73. PMID: 6104508.
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    523. Prusiner SB, Groth DF, Bildstein C, Masiarz FR, McKinley MP, Cochran SP. Electrophoretic properties of the scrapie agent in agarose gels. Proc Natl Acad Sci U S A. 1980 May; 77(5):2984-8. PMID: 6771764; PMCID: PMC349531.
    524. Prusiner SB, Cochran SP, Baringer JR, Groth D, Masiarz F, McKinley M, Bildstein C, Garfin D, Hadlow WJ, Race RE, Eklund CM. Slow viruses: molecular properties of the agents causing scrapie in mice and hamsters. Prog Clin Biol Res. 1980; 39:73-89. PMID: 6773068.
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    525. Chatigny MA, Dunn S, Ishimaru K, Eagleson JA, Prusiner S. Evaluation of a class III biological safety cabinet for enclosure of an ultracentrifuge. Appl Environ Microbiol. 1979 Nov; 38(5):934-9. PMID: 543704; PMCID: PMC243612.
    526. Prusiner S, Hadlow WJ, Eklund CM, Race RE, Cochran SP. Sedimentation characteristics of the scrapie agent from murine spleen and brain. Biochemistry. 1978 Nov 14; 17(23):4987-92. PMID: 214106.
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    527. Prusiner S, Hadlow WJ, Garfin DE, Cochran SP, Baringer JR, Race RE, Eklund CM. Partial purification and evidence for multiple molecular forms of the scrapie agent. Biochemistry. 1978 Nov 14; 17(23):4993-9. PMID: 102338.
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    528. Garfin DE, Stites DP, Perlman JD, Cochran SP, Prusiner SB. Mitogen stimulation of splenocytes from mice infected with scrapie agent. J Infect Dis. 1978 Sep; 138(3):396-400. PMID: 568156.
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    529. Baringer JR, Prusiner S. Experimental scrapie in mice: ultrastructural observations. Ann Neurol. 1978 Sep; 4(3):205-11. PMID: 568909.
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    530. Hittelman K, Mamelok RD, Prusiner S. Preservation by freezing of glucose and alanine transport into kidney membrane vesicles. Anal Biochem. 1978 Sep; 89(2):324-31. PMID: 727434.
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    531. Prusiner PE, Prusiner S. Partial purification and kinetics of gamma-glutamyl transpeptidase from bovine choroid plexus. J Neurochem. 1978 Jun; 30(6):1253-9. PMID: 27580.
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    532. Garfin DE, Stites DP, Zitnik LA, Prusiner S. Suppression of polyclonal B cell activation in scrapie-infected C3H/HeJ mice. J Immunol. 1978 Jun; 120(6):1986-90. PMID: 307027.
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    533. Prusiner PE, Prusiner S. Modulation of gamma-glutamyl transpeptidase activity from bovine choroid plexus. J Neurochem. 1978 Jun; 30(6):1261-7. PMID: 27581.
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    534. Prusiner S. An approach to the isolation of biological particles using sedimentation analysis. J Biol Chem. 1978 Feb 10; 253(3):916-21. PMID: 621210.
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    535. Prusiner S, Garfin DE, Cochran SP, Baringer JR, Hadlow WJ, Eklund CM, Race RE. Evidence for hydrophobic domains on the surface of the scrapie agent. Trans Am Neurol Assoc. 1978; 103:62-4. PMID: 117582.
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    536. Prusiner S, Hadlow WJ, Eklund CM, Race RE. Sedimentation properties of the scrapie agent. Proc Natl Acad Sci U S A. 1977 Oct; 74(10):4656-60. PMID: 412193; PMCID: PMC432006.
    537. Kirk G, Prusiner S. Comparative studies on membranes from bovine choroid plexus and rat kidney cortex. Life Sci. 1977 Sep 15; 21(6):833-40. PMID: 21337.
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    538. Raskin NH, Prusiner S. Carotidynia. Neurology. 1977 Jan; 27(1):43-6. PMID: 556819.
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    539. Prusiner S, Doak CW, Kirk G. A novel mechanism for group translocation: substrate-product reutilization by gamma-glutamyl transpeptidase in peptide and amino acid transport. J Cell Physiol. 1976 Dec; 89(4):853-63. PMID: 13082.
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    540. Prusiner S, Davis JN, Stadtman ER. Regulation of glutaminase B in Escherichia coli. I. Purification, properties, and cold lability. J Biol Chem. 1976 Jun 10; 251(11):3447-56. PMID: 6454.
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    541. Prusiner S, Stadtman ER. Regulation of glutaminase B in Escherichia coli. II. Modulaltion of activity by carbosylate and borate ions. J Biol Chem. 1976 Jun 10; 251(11):3457-62. PMID: 776969.
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    542. Prusiner S, Stadtman ER. Regulation of glutaminase B in Escherichia coli. III. Control by nucleotides and divalent cations. J Biol Chem. 1976 Jun 10; 251(11):3463-9. PMID: 776970.
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    543. Prusiner S. Regulation of glutaminase levels in Escherichia coli. J Bacteriol. 1975 Sep; 123(3):992-9. PMID: 239927; PMCID: PMC235824.
    544. Deuel TF, Prusiner S. Regulation of glutamine synthetase from Bacillus subtilis by divalent cations, feedback inhibitors, and L-glutamine. J Biol Chem. 1974 Jan 10; 249(1):257-64. PMID: 4149044.
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    545. Davis JN, Prusiner S. Stain for glutaminase activity. Anal Biochem. 1973 Jul; 54(1):272-5. PMID: 4125255.
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    546. Prusiner S, Miller RE, Valentine RC. Adenosine 3':5'-cyclic monophosphate control of the enzymes of glutamine metabolism in Escherichia coli. Proc Natl Acad Sci U S A. 1972 Oct; 69(10):2922-6. PMID: 4404145; PMCID: PMC389675.
    547. Prusiner S, Stadtman ER. On the regulation of glutaminase in E. coli: metabolite control. Biochem Biophys Res Commun. 1971 Dec 17; 45(6):1474-81. PMID: 4399639.
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    548. Prusiner SB, Milner LS, Long CW, Myers ML. Vacuum manifold for rapid assay of enzymes using radioactive tracers and ion exchange chromatography. Rev Sci Instrum. 1971 Apr; 42(4):493-4. PMID: 5546271.
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    549. Prusiner S, Milner L. A rapid radioactive assay for glutamine synthetase, glutaminase, asparagine synthetase, and asparaginase. Anal Biochem. 1970 Oct; 37(2):429-38. PMID: 4920285.
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    550. Lindberg O, Prusiner SB, Cannon B, Ching TM, Eisenhardt RH. Metabolic control in isolated brown fat cells. Lipids. 1970 Feb; 5(2):204-9. PMID: 4314248.
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    551. Prusiner S. Spectroscopic evidence for the control of respiration prior to phosphorylation in hamster brown fat cells. J Biol Chem. 1970 Jan 25; 245(2):382-9. PMID: 5412065.
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    552. Williamson JR, Prusiner S, Olson MS, Fukami M. Control of metabolism in brown adipose tissue. Lipids. 1970 Jan; 5(1):1-14. PMID: 5418206.
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    553. Reulen HJ, Steude U, Brendel W, Hilber C, Prusiner S. [Energetic disturbance of cation transport as a cause of intracellular brain edema]. Acta Neurochir (Wien). 1970; 22(2):129-66. PMID: 5521226.
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    554. Prusiner SB, Cannon B, Ching TM, Lindberg O. Oxidative metabolism in cells isolated from brown adipose tissue. 2. Catecholamine regulated respiratory control. Eur J Biochem. 1968 Dec; 7(1):51-7. PMID: 5707712.
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    555. Prusiner S, Wolfson SK. Hypothermic protection against cerebral edema of ischemia. Arch Neurol. 1968 Dec; 19(6):623-7. PMID: 5726773.
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    556. Prusiner S, Poe M. Thermodynamic cosiderations of mammalian thermogenesis. Nature. 1968 Oct 19; 220(5164):235-7. PMID: 5684848.
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    557. Prusiner SB, Cannon B, Lindberg O. Oxidative metabolism in cells isolated from brown adipose tissue. 1. Catecholamine and fatty acid stimulation of respiration. Eur J Biochem. 1968 Oct 17; 6(1):15-22. PMID: 5725810.
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    558. Prusiner SB, Eisenhardt RH, Rylander E, Lindberg O. The regulation of oxidative metabolism of isolated brown fat cells. Biochem Biophys Res Commun. 1968 Mar 12; 30(5):508-15. PMID: 5645437.
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    559. Prusiner S, Williamson JR, Chance B, Paddle BM. Pyridine nucleotide changes during thermogenesis in brown fat tissue in vivo. Arch Biochem Biophys. 1968 Feb; 123(2):368-77. PMID: 4296052.
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    560. Prusiner SB, Moskovitz PA, Wolfson SK. Relationship of acidemia to cerebral edema. Arch Surg. 1965 Dec; 91(6):902-5. PMID: 5842950.
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