Stephen Nishimura, MD

Title(s)Professor, Pathology
SchoolSchool of Medicine
Address1001 Potrero Avenue, #210
San Francisco CA 94110
Phone628-206-8212
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoResidency School of Medicine

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Structural mechanism of integrin-mediated TGF-b activation
    NIH R01HL134183Jul 4, 2016 - May 31, 2024
    Role: Principal Investigator
    Role of genetic variation in TGF-beta overactivation in COPD
    NIH R01HL113032Apr 1, 2012 - Mar 31, 2017
    Role: Principal Investigator
    Role of Squamous Metaplasia in Small Airways Disease in COPD
    NIH R01HL090662Sep 1, 2009 - Aug 31, 2011
    Role: Principal Investigator
    Integrin Regulation of Airway Epithelial Proliferation
    NIH K02HL070622Aug 1, 2002 - Jul 31, 2007
    Role: Principal Investigator
    Integrative Study of Brain Vascular Malformations
    NIH/NINDS P01NS044155Jul 1, 2002 - Mar 31, 2014
    Role: Co-Investigator
    Integrin alphavbeta8 Inhibits Airway Epithelial Cell Growth
    NIH R01HL063993Dec 1, 1999 - Mar 31, 2013
    Role: Principal Investigator
    DISTRIBUTION AND FUNCTION OF THE INTEGRIN ANDYB8
    NIH K08CA063148Jul 1, 1995 - Jun 30, 2001
    Role: Principal Investigator
    INTEGRINS AND BLASTOCYST-ENDOMETRIAL INTERACTION
    NIH F32CA009335Feb 10, 1993
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Dynamic allostery drives autocrine and paracrine TGF-ß signaling. Cell. 2024 Sep 12. Jin M, Seed RI, Cai G, Shing T, Wang L, Ito S, Cormier A, Wankowicz SA, Jespersen JM, Baron JL, Carey ND, Campbell MG, Yu Z, Tang PK, Cossio P, Wen W, Lou J, Marks J, Nishimura SL, Cheng Y. PMID: 39288764.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    2. Macrophage Cx43 Is Necessary for Fibroblast Cytosolic Calcium and Lung Fibrosis After Injury. Front Immunol. 2022; 13:880887. Bhattacharyya A, Torre P, Yadav P, Boostanpour K, Chen TY, Tsukui T, Sheppard D, Muramatsu R, Seed RI, Nishimura SL, Jung JB, Tang XZ, Allen CDC, Bhattacharya M. PMID: 35634278; PMCID: PMC9134074.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    3. Measurement of Cell Intrinsic TGF-β Activation Mediated by the Integrin αvβ8. Bio Protoc. 2022 Apr 20; 12(8):e4385. Seed RI, Nishimura SL. PMID: 35800099; PMCID: PMC9081475.
      View in: PubMed   Mentions:
    4. Acquisition of cellular properties during alveolar formation requires differential activity and distribution of mitochondria. Elife. 2022 04 06; 11. Zhang K, Yao E, Chen B, Chuang E, Wong J, Seed RI, Nishimura SL, Wolters PJ, Chuang PT. PMID: 35384838; PMCID: PMC9183236.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    5. Diagnosis of acute mesenteric ischemia assisted by dual-energy CT: a case report. Emerg Radiol. 2022 Jun; 29(3):611-614. Chen JV, Ohliger MA, Chung M, Sugi MD, Ye J, Nishimura SL, Choi HH. PMID: 35128620.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. TGFβ activating integrins β6 and β8 are dysregulated in inflammatory skin disease and cutaneous melanoma. J Dermatol Sci. 2022 Apr; 106(1):2-11. Nguyen BA, Ho J, De La Cruz Diaz JS, Nishimura S, Kaplan DH. PMID: 35277328; PMCID: PMC9124681.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    7. Role of the transcriptional regulator SP140 in resistance to bacterial infections via repression of type I interferons. Elife. 2021 06 21; 10. Ji DX, Witt KC, Kotov DI, Margolis SR, Louie A, Chevée V, Chen KJ, Gaidt MM, Dhaliwal HS, Lee AY, Nishimura SL, Zamboni DS, Kramnik I, Portnoy DA, Darwin KH, Vance RE. PMID: 34151776; PMCID: PMC8248984.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    8. A tumor-specific mechanism of Treg enrichment mediated by the integrin αvβ8. Sci Immunol. 2021 03 26; 6(57). Seed RI, Kobayashi K, Ito S, Takasaka N, Cormier A, Jespersen JM, Publicover J, Trilok S, Combes AJ, Chew NW, Chapman J, Krummel MF, Lou J, Marks J, Cheng Y, Baron JL, Nishimura SL. PMID: 33771888; PMCID: PMC8425767.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    9. Mapping the Endothelial Cell S-Sulfhydrome Highlights the Crucial Role of Integrin Sulfhydration in Vascular Function. Circulation. 2021 03 02; 143(9):935-948. Bibli SI, Hu J, Looso M, Weigert A, Ratiu C, Wittig J, Drekolia MK, Tombor L, Randriamboavonjy V, Leisegang MS, Goymann P, Delgado Lagos F, Fisslthaler B, Zukunft S, Kyselova A, Justo AFO, Heidler J, Tsilimigras D, Brandes RP, Dimmeler S, Papapetropoulos A, Knapp S, Offermanns S, Wittig I, Nishimura SL, Sigala F, Fleming I. PMID: 33307764.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    10. Age-dependent regulation of cell-mediated collagen turnover. JCI Insight. 2020 05 21; 5(10). Podolsky MJ, Yang CD, Valenzuela CL, Datta R, Huang SK, Nishimura SL, Dallas SL, Wolters PJ, Le Saux CJ, Atabai K. PMID: 32315288; PMCID: PMC7259530.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    11. Cryo-EM Reveals Integrin-Mediated TGF-β Activation without Release from Latent TGF-β. Cell. 2020 02 06; 180(3):490-501.e16. Campbell MG, Cormier A, Ito S, Seed RI, Bondesson AJ, Lou J, Marks JD, Baron JL, Cheng Y, Nishimura SL. PMID: 31955848; PMCID: PMC7238552.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansAnimalsCells
    12. Integrin αvβ8-expressing tumor cells evade host immunity by regulating TGF-β activation in immune cells. JCI Insight. 2018 10 18; 3(20). Takasaka N, Seed RI, Cormier A, Bondesson AJ, Lou J, Elattma A, Ito S, Yanagisawa H, Hashimoto M, Ma R, Levine MD, Publicover J, Potts R, Jespersen JM, Campbell MG, Conrad F, Marks JD, Cheng Y, Baron JL, Nishimura SL. PMID: 30333313; PMCID: PMC6237456.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    13. PRKN-regulated mitophagy and cellular senescence during COPD pathogenesis. Autophagy. 2019 03; 15(3):510-526. Araya J, Tsubouchi K, Sato N, Ito S, Minagawa S, Hara H, Hosaka Y, Ichikawa A, Saito N, Kadota T, Yoshida M, Fujita Y, Utsumi H, Kobayashi K, Yanagisawa H, Hashimoto M, Wakui H, Ishikawa T, Numata T, Kaneko Y, Asano H, Yamashita M, Odaka M, Morikawa T, Nishimura SL, Nakayama K, Kuwano K. PMID: 30290714; PMCID: PMC6351145.
      View in: PubMed   Mentions: 81     Fields:    Translation:HumansAnimalsCells
    14. Cryo-EM structure of the αvβ8 integrin reveals a mechanism for stabilizing integrin extension. Nat Struct Mol Biol. 2018 08; 25(8):698-704. Cormier A, Campbell MG, Ito S, Wu S, Lou J, Marks J, Baron JL, Nishimura SL, Cheng Y. PMID: 30061598; PMCID: PMC6214843.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    15. An OX40/OX40L interaction directs successful immunity to hepatitis B virus. Sci Transl Med. 2018 03 21; 10(433). Publicover J, Gaggar A, Jespersen JM, Halac U, Johnson AJ, Goodsell A, Avanesyan L, Nishimura SL, Holdorf M, Mansfield KG, Judge JB, Koshti A, Croft M, Wakil AE, Rosenthal P, Pai E, Cooper S, Baron JL. PMID: 29563320; PMCID: PMC6018058.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    16. Cigarette smoke exposure worsens acute lung injury in antibiotic-treated bacterial pneumonia in mice. Am J Physiol Lung Cell Mol Physiol. 2018 07 01; 315(1):L25-L40. Gotts JE, Chun L, Abbott J, Fang X, Takasaka N, Nishimura SL, Springer ML, Schick SF, Calfee CS, Matthay MA. PMID: 29543040; PMCID: PMC6087899.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCellsPHPublic Health
    17. Blocking immunosuppression by human Tregs in vivo with antibodies targeting integrin αVβ8. Proc Natl Acad Sci U S A. 2017 11 21; 114(47):E10161-E10168. Stockis J, Liénart S, Colau D, Collignon A, Nishimura SL, Sheppard D, Coulie PG, Lucas S. PMID: 29109269; PMCID: PMC5703296.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    18. Cigarette Smoke Exposure Worsens Endotoxin-Induced Lung Injury and Pulmonary Edema in Mice. Nicotine Tob Res. 2017 Sep 01; 19(9):1033-1039. Gotts JE, Abbott J, Fang X, Yanagisawa H, Takasaka N, Nishimura SL, Calfee CS, Matthay MA. PMID: 28340238; PMCID: PMC5896544.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsPHPublic Health
    19. Role of IL-17A in murine models of COPD airway disease. Am J Physiol Lung Cell Mol Physiol. 2017 01 01; 312(1):L122-L130. Yanagisawa H, Hashimoto M, Minagawa S, Takasaka N, Ma R, Moermans C, Ito S, Araya J, Budelsky A, Goodsell A, Baron JL, Nishimura SL. PMID: 27913421; PMCID: PMC5283930.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    20. Integrin β8 Deletion Enhances Vascular Dysplasia and Hemorrhage in the Brain of Adult Alk1 Heterozygous Mice. Transl Stroke Res. 2016 12; 7(6):488-496. Ma L, Shen F, Jun K, Bao C, Kuo R, Young WL, Nishimura SL, Su H. PMID: 27352867; PMCID: PMC5065781.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    21. Liver capsule: Age-influenced hepatic immune priming determines HBV infection fate: Implications from mouse to man. Hepatology. 2016 Jan; 63(1):260. Publicover J, Jespersen JM, Johnson AJ, Nishimura SL, Goodsell A, Wakil AE, Rosenthal P, Pai E, Avanesyan L, Cooper S, Baron JL. PMID: 26457468; PMCID: PMC4806644.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    22. TGF-β-Dependent Dendritic Cell Chemokinesis in Murine Models of Airway Disease. J Immunol. 2015 Aug 01; 195(3):1182-90. Hashimoto M, Yanagisawa H, Minagawa S, Sen D, Ma R, Murray LA, Tsui P, Lou J, Marks JD, Baron JL, Krummel MF, Nishimura SL. PMID: 26109638; PMCID: PMC4506848.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    23. Transforming Growth Factor-β and Interleukin-1β Signaling Pathways Converge on the Chemokine CCL20 Promoter. J Biol Chem. 2015 Jun 05; 290(23):14717-28. Brand OJ, Somanath S, Moermans C, Yanagisawa H, Hashimoto M, Cambier S, Markovics J, Bondesson AJ, Hill A, Jablons D, Wolters P, Lou J, Marks JD, Baron JL, Nishimura SL. PMID: 25918170; PMCID: PMC4505537.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    24. A critical role for dendritic cells in the evolution of IL-1β-mediated murine airway disease. J Immunol. 2015 Apr 15; 194(8):3962-9. Hashimoto M, Yanagisawa H, Minagawa S, Sen D, Goodsell A, Ma R, Moermans C, McKnelly KJ, Baron JL, Krummel MF, Nishimura SL. PMID: 25786688; PMCID: PMC4390519.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    25. PARK2-mediated mitophagy is involved in regulation of HBEC senescence in COPD pathogenesis. Autophagy. 2015; 11(3):547-59. Ito S, Araya J, Kurita Y, Kobayashi K, Takasaka N, Yoshida M, Hara H, Minagawa S, Wakui H, Fujii S, Kojima J, Shimizu K, Numata T, Kawaishi M, Odaka M, Morikawa T, Harada T, Nishimura SL, Kaneko Y, Nakayama K, Kuwano K. PMID: 25714760; PMCID: PMC4502689.
      View in: PubMed   Mentions: 116     Fields:    Translation:HumansCells
    26. Selective targeting of TGF-β activation to treat fibroinflammatory airway disease. Sci Transl Med. 2014 Jun 18; 6(241):241ra79. Minagawa S, Lou J, Seed RI, Cormier A, Wu S, Cheng Y, Murray L, Tsui P, Connor J, Herbst R, Govaerts C, Barker T, Cambier S, Yanagisawa H, Goodsell A, Hashimoto M, Brand OJ, Cheng R, Ma R, McKnelly KJ, Wen W, Hill A, Jablons D, Wolters P, Kitamura H, Araya J, Barczak AJ, Erle DJ, Reichardt LF, Marks JD, Baron JL, Nishimura SL. PMID: 24944194; PMCID: PMC4341974.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimals
    27. Reprogramming tumor-infiltrating dendritic cells for CD103+ CD8+ mucosal T-cell differentiation and breast cancer rejection. Cancer Immunol Res. 2014 May; 2(5):487-500. Wu TC, Xu K, Banchereau R, Marches F, Yu CI, Martinek J, Anguiano E, Pedroza-Gonzalez A, Snipes GJ, O'Shaughnessy J, Nishimura S, Liu YJ, Pascual V, Banchereau J, Oh S, Palucka K. PMID: 24795361; PMCID: PMC4014008.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    28. Functional genomic screen identifies novel mediators of collagen uptake. Mol Biol Cell. 2014 Mar; 25(5):583-93. Lee TH, McKleroy W, Khalifeh-Soltani A, Sakuma S, Lazarev S, Riento K, Nishimura SL, Nichols BJ, Atabai K. PMID: 24403604; PMCID: PMC3937085.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimals
    29. Autophagy induction by SIRT6 through attenuation of insulin-like growth factor signaling is involved in the regulation of human bronchial epithelial cell senescence. J Immunol. 2014 Feb 01; 192(3):958-68. Takasaka N, Araya J, Hara H, Ito S, Kobayashi K, Kurita Y, Wakui H, Yoshii Y, Yumino Y, Fujii S, Minagawa S, Tsurushige C, Kojima J, Numata T, Shimizu K, Kawaishi M, Kaneko Y, Kamiya N, Hirano J, Odaka M, Morikawa T, Nishimura SL, Nakayama K, Kuwano K. PMID: 24367027.
      View in: PubMed   Mentions: 88     Fields:    Translation:HumansAnimalsCells
    30. Age-dependent hepatic lymphoid organization directs successful immunity to hepatitis B. J Clin Invest. 2013 Sep; 123(9):3728-39. Publicover J, Gaggar A, Nishimura S, Van Horn CM, Goodsell A, Muench MO, Reinhardt RL, van Rooijen N, Wakil AE, Peters M, Cyster JG, Erle DJ, Rosenthal P, Cooper S, Baron JL. PMID: 23925290; PMCID: PMC3754256.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    31. Insufficient autophagy in idiopathic pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2013 Jan 01; 304(1):L56-69. Araya J, Kojima J, Takasaka N, Ito S, Fujii S, Hara H, Yanagisawa H, Kobayashi K, Tsurushige C, Kawaishi M, Kamiya N, Hirano J, Odaka M, Morikawa T, Nishimura SL, Kawabata Y, Hano H, Nakayama K, Kuwano K. PMID: 23087019.
      View in: PubMed   Mentions: 156     Fields:    Translation:HumansCells
    32. Insufficient autophagy promotes bronchial epithelial cell senescence in chronic obstructive pulmonary disease. Oncoimmunology. 2012 Aug 01; 1(5):630-641. Fujii S, Hara H, Araya J, Takasaka N, Kojima J, Ito S, Minagawa S, Yumino Y, Ishikawa T, Numata T, Kawaishi M, Hirano J, Odaka M, Morikawa T, Nishimura S, Nakayama K, Kuwano K. PMID: 22934255; PMCID: PMC3429567.
      View in: PubMed   Mentions: 111     Fields:    
    33. Interleukin-1beta induces increased transcriptional activation of the transforming growth factor-beta-activating integrin subunit beta8 through altering chromatin architecture. J Biol Chem. 2011 Oct 21; 286(42):36864-74. Markovics JA, Araya J, Cambier S, Somanath S, Gline S, Jablons D, Hill A, Wolters PJ, Nishimura SL. PMID: 21878622; PMCID: PMC3196125.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    34. Mouse and human lung fibroblasts regulate dendritic cell trafficking, airway inflammation, and fibrosis through integrin αvβ8-mediated activation of TGF-β. J Clin Invest. 2011 Jul; 121(7):2863-75. Kitamura H, Cambier S, Somanath S, Barker T, Minagawa S, Markovics J, Goodsell A, Publicover J, Reichardt L, Jablons D, Wolters P, Hill A, Marks JD, Lou J, Pittet JF, Gauldie J, Baron JL, Nishimura SL. PMID: 21646718; PMCID: PMC3223836.
      View in: PubMed   Mentions: 99     Fields:    Translation:HumansAnimalsCells
    35. Insulin-dependent phosphatidylinositol 3-kinase/Akt and ERK signaling pathways inhibit TLR3-mediated human bronchial epithelial cell apoptosis. J Immunol. 2011 Jul 01; 187(1):510-9. Numata T, Araya J, Fujii S, Hara H, Takasaka N, Kojima J, Minagawa S, Yumino Y, Kawaishi M, Hirano J, Odaka M, Morikawa T, Nishimura SL, Nakayama K, Kuwano K. PMID: 21646299.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    36. IL-21 is pivotal in determining age-dependent effectiveness of immune responses in a mouse model of human hepatitis B. J Clin Invest. 2011 Mar; 121(3):1154-62. Publicover J, Goodsell A, Nishimura S, Vilarinho S, Wang ZE, Avanesyan L, Spolski R, Leonard WJ, Cooper S, Baron JL. PMID: 21393863; PMCID: PMC3049376.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansAnimalsCells
    37. Accelerated epithelial cell senescence in IPF and the inhibitory role of SIRT6 in TGF-β-induced senescence of human bronchial epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2011 Mar; 300(3):L391-401. Minagawa S, Araya J, Numata T, Nojiri S, Hara H, Yumino Y, Kawaishi M, Odaka M, Morikawa T, Nishimura SL, Nakayama K, Kuwano K. PMID: 21224216; PMCID: PMC3284316.
      View in: PubMed   Mentions: 173     Fields:    Translation:HumansCells
    38. Transcription of the transforming growth factor beta activating integrin beta8 subunit is regulated by SP3, AP-1, and the p38 pathway. J Biol Chem. 2010 Aug 06; 285(32):24695-706. Markovics JA, Araya J, Cambier S, Jablons D, Hill A, Wolters PJ, Nishimura SL. PMID: 20519498; PMCID: PMC2915706.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    39. Low prevalence of chronic beryllium disease among workers at a nuclear weapons research and development facility. J Occup Environ Med. 2010 Jun; 52(6):647-52. Arjomandi M, Seward J, Gotway MB, Nishimura S, Fulton GP, Thundiyil J, King TE, Harber P, Balmes JR. PMID: 20523233; PMCID: PMC3313491.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    40. Fibrogenic reactions in lung disease. Annu Rev Pathol. 2010; 5:77-98. Araya J, Nishimura SL. PMID: 20078216.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansCells
    41. Reduced expression of integrin alphavbeta8 is associated with brain arteriovenous malformation pathogenesis. Am J Pathol. 2010 Feb; 176(2):1018-27. Su H, Kim H, Pawlikowska L, Kitamura H, Shen F, Cambier S, Markovics J, Lawton MT, Sidney S, Bollen AW, Kwok PY, Reichardt L, Young WL, Yang GY, Nishimura SL. PMID: 20019187; PMCID: PMC2808104.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    42. Fusion of epithelial cells by Epstein-Barr virus proteins is triggered by binding of viral glycoproteins gHgL to integrins alphavbeta6 or alphavbeta8. Proc Natl Acad Sci U S A. 2009 Dec 01; 106(48):20464-9. Chesnokova LS, Nishimura SL, Hutt-Fletcher LM. PMID: 19920174; PMCID: PMC2787161.
      View in: PubMed   Mentions: 127     Fields:    Translation:HumansCells
    43. Integrin-mediated transforming growth factor-beta activation, a potential therapeutic target in fibrogenic disorders. Am J Pathol. 2009 Oct; 175(4):1362-70. Nishimura SL. PMID: 19729474; PMCID: PMC2751532.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansAnimals
    44. Restoring transcription factor HoxA5 expression inhibits the growth of experimental hemangiomas in the brain. J Neuropathol Exp Neurol. 2009 Jun; 68(6):626-32. Zhu Y, Cuevas IC, Gabriel RA, Su H, Nishimura S, Gao P, Fields A, Hao Q, Young WL, Yang GY, Boudreau NJ. PMID: 19458547; PMCID: PMC2728585.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    45. mTOR mediates survival signals in malignant mesothelioma grown as tumor fragment spheroids. Am J Respir Cell Mol Biol. 2008 Nov; 39(5):576-83. Wilson SM, Barbone D, Yang TM, Jablons DM, Bueno R, Sugarbaker DJ, Nishimura SL, Gordon GJ, Broaddus VC. PMID: 18511708; PMCID: PMC2574528.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    46. Targeted drug delivery to mesothelioma cells using functionally selected internalizing human single-chain antibodies. Mol Cancer Ther. 2008 Mar; 7(3):569-78. An F, Drummond DC, Wilson S, Kirpotin DB, Nishimura SL, Broaddus VC, Liu B. PMID: 18319332; PMCID: PMC2943512.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    47. Blockade of NKG2D on NKT cells prevents hepatitis and the acute immune response to hepatitis B virus. Proc Natl Acad Sci U S A. 2007 Nov 13; 104(46):18187-92. Vilarinho S, Ogasawara K, Nishimura S, Lanier LL, Baron JL. PMID: 17991774; PMCID: PMC2084318.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimalsCells
    48. Squamous metaplasia amplifies pathologic epithelial-mesenchymal interactions in COPD patients. J Clin Invest. 2007 Nov; 117(11):3551-62. Araya J, Cambier S, Markovics JA, Wolters P, Jablons D, Hill A, Finkbeiner W, Jones K, Broaddus VC, Sheppard D, Barzcak A, Xiao Y, Erle DJ, Nishimura SL. PMID: 17965775; PMCID: PMC2040320.
      View in: PubMed   Mentions: 122     Fields:    Translation:HumansAnimalsCells
    49. Integrin-mediated transforming growth factor-beta activation regulates homeostasis of the pulmonary epithelial-mesenchymal trophic unit. Am J Pathol. 2006 Aug; 169(2):405-15. Araya J, Cambier S, Morris A, Finkbeiner W, Nishimura SL. PMID: 16877343; PMCID: PMC1698780.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    50. Case report: a case of wood-smoke-related pulmonary disease. Environ Health Perspect. 2006 May; 114(5):759-62. Diaz JV, Koff J, Gotway MB, Nishimura S, Balmes JR. PMID: 16675433; PMCID: PMC1459932.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansPHPublic Health
    51. Activation of transforming growth factor-beta by the integrin alphavbeta8 delays epithelial wound closure. Am J Respir Cell Mol Biol. 2006 Aug; 35(2):252-9. Neurohr C, Nishimura SL, Sheppard D. PMID: 16574941; PMCID: PMC2643260.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    52. A novel in vitro model of human mesothelioma for studying tumor biology and apoptotic resistance. Am J Respir Cell Mol Biol. 2005 Dec; 33(6):541-8. Kim KU, Wilson SM, Abayasiriwardana KS, Collins R, Fjellbirkeland L, Xu Z, Jablons DM, Nishimura SL, Broaddus VC. PMID: 16123394; PMCID: PMC2715331.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    53. Integrin alpha(v)beta8-mediated activation of transforming growth factor-beta by perivascular astrocytes: an angiogenic control switch. Am J Pathol. 2005 Jun; 166(6):1883-94. Cambier S, Gline S, Mu D, Collins R, Araya J, Dolganov G, Einheber S, Boudreau N, Nishimura SL. PMID: 15920172; PMCID: PMC1602409.
      View in: PubMed   Mentions: 94     Fields:    Translation:HumansCells
    54. A 50-A separation of the integrin alpha v beta 3 extracellular domain C termini reveals an intermediate activation state. J Biol Chem. 2004 Dec 24; 279(52):54567-72. Gline SE, Cambier S, Govaerts C, Nishimura SL. PMID: 15475365.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    55. Integrin alphavbeta8 functions as a receptor for foot-and-mouth disease virus: role of the beta-chain cytodomain in integrin-mediated infection. J Virol. 2004 May; 78(9):4533-40. Jackson T, Clark S, Berryman S, Burman A, Cambier S, Mu D, Nishimura S, King AM. PMID: 15078934; PMCID: PMC387692.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansAnimalsCells
    56. Sarcoidosis following HIV infection: evidence for CD4+ lymphocyte dependence. Chest. 2003 Sep; 124(3):929-35. Morris DG, Jasmer RM, Huang L, Gotway MB, Nishimura S, King TE. PMID: 12970019.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    57. Integrin alphavbeta8-mediated activation of transforming growth factor-beta inhibits human airway epithelial proliferation in intact bronchial tissue. Am J Pathol. 2003 Aug; 163(2):533-42. Fjellbirkeland L, Cambier S, Broaddus VC, Hill A, Brunetta P, Dolganov G, Jablons D, Nishimura SL. PMID: 12875973; PMCID: PMC1868219.
      View in: PubMed   Mentions: 29     Fields:    Translation:Humans
    58. Fas activation induces renal tubular epithelial cell beta 8 integrin expression and function in the absence of apoptosis. J Biol Chem. 2002 Dec 06; 277(49):47826-33. Jarad G, Wang B, Khan S, DeVore J, Miao H, Wu K, Nishimura SL, Wible BA, Konieczkowski M, Sedor JR, Schelling JR. PMID: 12324452.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    59. The integrin alpha(v)beta8 mediates epithelial homeostasis through MT1-MMP-dependent activation of TGF-beta1. J Cell Biol. 2002 Apr 29; 157(3):493-507. Mu D, Cambier S, Fjellbirkeland L, Baron JL, Munger JS, Kawakatsu H, Sheppard D, Broaddus VC, Nishimura SL. PMID: 11970960; PMCID: PMC2173277.
      View in: PubMed   Mentions: 355     Fields:    Translation:HumansAnimalsCells
    60. Activation of a nonclassical NKT cell subset in a transgenic mouse model of hepatitis B virus infection. Immunity. 2002 Apr; 16(4):583-94. Baron JL, Gardiner L, Nishimura S, Shinkai K, Locksley R, Ganem D. PMID: 11970881.
      View in: PubMed   Mentions: 93     Fields:    Translation:HumansAnimalsCells
    61. A role for the integrin alphavbeta8 in the negative regulation of epithelial cell growth. Cancer Res. 2000 Dec 15; 60(24):7084-93. Cambier S, Mu DZ, O'Connell D, Boylen K, Travis W, Liu WH, Broaddus VC, Nishimura SL. PMID: 11156415.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    62. Subacute hypersensitivity pneumonitis in an HIV infected patient receiving antiretroviral therapy. Thorax. 2000 Jul; 55(7):625-7. Morris AM, Nishimura S, Huang L. PMID: 10856327; PMCID: PMC1745796.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    63. Asbestos-induced pleural disease. Clin Chest Med. 1998 Jun; 19(2):311-29. Nishimura SL, Broaddus VC. PMID: 9646983.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    64. Synaptic and glial localization of the integrin alphavbeta8 in mouse and rat brain. Brain Res. 1998 Apr 27; 791(1-2):271-82. Nishimura SL, Boylen KP, Einheber S, Milner TA, Ramos DM, Pytela R. PMID: 9593935.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    65. Stromal fibroblasts influence oral squamous-cell carcinoma cell interactions with tenascin-C. Int J Cancer. 1997 Jul 17; 72(2):369-76. Ramos DM, Chen BL, Boylen K, Stern M, Kramer RH, Sheppard D, Nishimura SL, Greenspan D, Zardi L, Pytela R. PMID: 9219848.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    66. Expression of the beta 6 integrin subunit in development, neoplasia and tissue repair suggests a role in epithelial remodeling. J Cell Sci. 1995 Jun; 108 ( Pt 6):2241-51. Breuss JM, Gallo J, DeLisser HM, Klimanskaya IV, Folkesson HG, Pittet JF, Nishimura SL, Aldape K, Landers DV, Carpenter W, et al. PMID: 7673344.
      View in: PubMed   Mentions: 183     Fields:    Translation:HumansAnimals
    67. Integrin alpha v beta 8. Interaction with vitronectin and functional divergence of the beta 8 cytoplasmic domain. J Biol Chem. 1994 Nov 18; 269(46):28708-15. Nishimura SL, Sheppard D, Pytela R. PMID: 7525578.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansCells
    68. Role of the integrin alpha v beta 6 in cell attachment to fibronectin. Heterologous expression of intact and secreted forms of the receptor. J Biol Chem. 1994 Mar 04; 269(9):6940-8. Weinacker A, Chen A, Agrez M, Cone RI, Nishimura S, Wayner E, Pytela R, Sheppard D. PMID: 8120056.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansAnimalsCells
    69. Evaluation of an enzyme immunoassay for detection of cryptococcal capsular polysaccharide antigen in serum and cerebrospinal fluid. J Clin Microbiol. 1993 Jan; 31(1):97-101. Frank UK, Nishimura SL, Li NC, Sugai K, Yajko DM, Hadley WK, Ng VL. PMID: 8417038; PMCID: PMC262628.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    70. Clinical and pathological features of bacillary peliosis hepatis in association with human immunodeficiency virus infection. N Engl J Med. 1990 Dec 06; 323(23):1581-6. Perkocha LA, Geaghan SM, Yen TS, Nishimura SL, Chan SP, Garcia-Kennedy R, Honda G, Stoloff AC, Klein HZ, Goldman RL, et al. PMID: 2233946.
      View in: PubMed   Mentions: 43     Fields:    Translation:Humans
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