Jeremy Reiter, MD, PhD

SchoolUCSF School of Medicine
DepartmentBiochemistry and Biophysics
Address555 Mission Bay Blvd South
San Francisco CA 94158
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoM.D.2001 Medicine
    University of California, San FranciscoPh.D.1999 Graduate Division (Biochemistry)

    Collapse Overview 
    Collapse Overview
    Smith Cardiovascular Research Building
    Room 352G, Box 3120
    555 Mission Bay Blvd South

    Hedgehog, cilia, basal cell carcinoma, medulloblastoma, stem cell, centriole, centrosome, Smoothened, transition zone, Meckel syndrome

    Collapse Research 
    Collapse Research Activities and Funding
    Restoring ciliogenesis as a novel approach to blocking breast cancer growth
    NIH/NCI R21CA207659Mar 8, 2017 - Feb 28, 2019
    Role: Co-Principal Investigator
    Understanding Ciliary Functions in Mammalian Development
    NIH/NICHD R01HD089918Dec 10, 2016 - Nov 30, 2021
    Role: Principal Investigator
    Obesity in Ciliopathies: How Neuronal Primary Cilia Control Appetite
    NIH/NIDDK R01DK106404Jun 1, 2016 - Apr 30, 2020
    Role: Co-Principal Investigator
    A high content screen dissecting ciliogenesis and oncogenic Hedgehog signaling
    NIH/NCI R01CA181231Mar 23, 2016 - Feb 28, 2019
    Role: Principal Investigator
    UCSF Nutrition Obesity Research Center
    NIH/NIDDK P30DK098722Aug 1, 2015 - Jul 31, 2020
    Role: Co-Investigator
    Transition zone control of ciliary signaling
    NIH/NIGMS R01GM095941Jul 18, 2011 - Apr 30, 2019
    Role: Principal Investigator
    A novel high content screen for regulators of ciliogenesis and Hedgehog signaling
    NIH/NINDS R21NS066448Sep 27, 2010 - Aug 31, 2012
    Role: Co-Principal Investigator
    Hedgehog signaling at the cell's antenna: Smoothened and the primary cilium
    NIH/NIAMS R01AR054396Dec 1, 2006 - Jun 30, 2020
    Role: Principal Investigator
    Embryonic Stem Cell Formation of Definitive Endoderm
    NIH/NIDDK R21DK069423Sep 30, 2004 - Jul 31, 2007
    Role: Principal Investigator
    Semaphorin-plexin signaling &vertebrate cell movement
    NIH/NICHD F32HD043591Feb 5, 2003 - Jan 1, 2004
    Role: Principal Investigator
    Predoctoral Training in Developmental Biology
    NIH/NICHD T32HD007470Jul 1, 1994 - Apr 30, 2019
    Role: Principal Investigator

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    Collapse Global Health

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Sigg MA, Menchen T, Lee C, Johnson J, Jungnickel MK, Choksi SP, Garcia G, Busengdal H, Dougherty GW, Pennekamp P, Werner C, Rentzsch F, Florman HM, Krogan N, Wallingford JB, Omran H, Reiter J. Evolutionary Proteomics Uncovers Ancient Associations of Cilia with Signaling Pathways. Dev Cell. 2017 12 18; 43(6):744-762.e11. PMID: 29257953.
      View in: PubMed
    2. Shi X, Garcia Iii G, Van De Weghe JC, McGorty R, Pazour GJ, Doherty D, Huang B, Reiter JF. Super-resolution microscopy reveals that disruption of ciliary transition-zone architecture causes Joubert syndrome. Nat Cell Biol. 2017 Aug 28. PMID: 28846093.
      View in: PubMed
    3. Kopinke D, Roberson EC, Reiter JF. Ciliary Hedgehog Signaling Restricts Injury-Induced Adipogenesis. Cell. 2017 Jul 13; 170(2):340-351.e12. PMID: 28709001.
      View in: PubMed
    4. Reiter JF, Leroux MR. Genes and molecular pathways underpinning ciliopathies. Nat Rev Mol Cell Biol. 2017 Sep; 18(9):533-547. PMID: 28698599.
      View in: PubMed
    5. Garcia-Gonzalo FR, Reiter JF. Open Sesame: How Transition Fibers and the Transition Zone Control Ciliary Composition. Cold Spring Harb Perspect Biol. 2017 Feb 01; 9(2). PMID: 27770015.
      View in: PubMed
    6. Vaisse C, Reiter JF, Berbari NF. Cilia and Obesity. Cold Spring Harb Perspect Biol. 2017 Jan 17. PMID: 28096262.
      View in: PubMed
    7. Phua SC, Chiba S, Suzuki M, Su E, Roberson EC, Pusapati GV, Setou M, Rohatgi R, Reiter JF, Ikegami K, Inoue T. Dynamic Remodeling of Membrane Composition Drives Cell Cycle through Primary Cilia Excision. Cell. 2017 Jan 12; 168(1-2):264-279.e15. PMID: 28086093.
      View in: PubMed
    8. Jayaraman D, Kodani A, Gonzalez DM, Mancias JD, Mochida GH, Vagnoni C, Johnson J, Krogan N, Harper JW, Reiter J, Yu TW, Bae BI, Walsh CA. Microcephaly Proteins Wdr62 and Aspm Define a Mother Centriole Complex Regulating Centriole Biogenesis, Apical Complex, and Cell Fate. Neuron. 2016 Nov 23; 92(4):813-828. PMID: 27974163.
      View in: PubMed
    9. Zhang X, Chen MH, Wu X, Kodani A, Fan J, Doan R, Ozawa M, Ma J, Yoshida N, Reiter JF, Black DL, Kharchenko PV, Sharp PA, Walsh CA. Cell-Type-Specific Alternative Splicing Governs Cell Fate in the Developing Cerebral Cortex. Cell. 2016 Aug 25; 166(5):1147-1162.e15. PMID: 27565344.
      View in: PubMed
    10. Garcia G, Reiter JF. A primer on the mouse basal body. Cilia. 2016; 5:17. PMID: 27114821; PMCID: PMC4843204.
    11. Li C, Jensen VL, Park K, Kennedy J, Garcia-Gonzalo FR, Romani M, De Mori R, Bruel AL, Gaillard D, Doray B, Lopez E, Rivière JB, Faivre L, Thauvin-Robinet C, Reiter JF, Blacque OE, Valente EM, Leroux MR. MKS5 and CEP290 Dependent Assembly Pathway of the Ciliary Transition Zone. PLoS Biol. 2016 Mar; 14(3):e1002416. PMID: 26982032; PMCID: PMC4794247.
    12. Dinsmore C, Reiter JF. Endothelial primary cilia inhibit atherosclerosis. EMBO Rep. 2016 Feb; 17(2):156-66. PMID: 26769565.
      View in: PubMed
    13. Yee LE, Garcia-Gonzalo FR, Bowie RV, Li C, Kennedy JK, Ashrafi K, Blacque OE, Leroux MR, Reiter JF. Conserved Genetic Interactions between Ciliopathy Complexes Cooperatively Support Ciliogenesis and Ciliary Signaling. PLoS Genet. 2015 Nov; 11(11):e1005627. PMID: 26540106; PMCID: PMC4635004.
    14. Kodani A, Yu TW, Johnson JR, Jayaraman D, Johnson TL, Al-Gazali L, Sztriha L, Partlow JN, Kim H, Krup AL, Dammermann A, Krogan NJ, Walsh CA, Reiter JF. Centriolar satellites assemble centrosomal microcephaly proteins to recruit CDK2 and promote centriole duplication. Elife. 2015 Aug 22; 4. PMID: 26297806; PMCID: PMC4574112.
    15. Roberson EC, Dowdle WE, Ozanturk A, Garcia-Gonzalo FR, Li C, Halbritter J, Elkhartoufi N, Porath JD, Cope H, Ashley-Koch A, Gregory S, Thomas S, Sayer JA, Saunier S, Otto EA, Katsanis N, Davis EE, Attié-Bitach T, Hildebrandt F, Leroux MR, Reiter JF. TMEM231, mutated in orofaciodigital and Meckel syndromes, organizes the ciliary transition zone. J Cell Biol. 2015 Apr 13; 209(1):129-42. PMID: 25869670; PMCID: PMC4395494.
    16. Yee LE, Reiter JF. Ciliary vesicle formation: a prelude to ciliogenesis. Dev Cell. 2015 Mar 23; 32(6):665-6. PMID: 25805133.
      View in: PubMed
    17. Vagnozzi AN, Reiter JF, Wong SY. Hair follicle and interfollicular epidermal stem cells make varying contributions to wound regeneration. Cell Cycle. 2015; 14(21):3408-17. PMID: 26398918; PMCID: PMC4825603.
    18. Hu WF, Pomp O, Ben-Omran T, Kodani A, Henke K, Mochida GH, Yu TW, Woodworth MB, Bonnard C, Raj GS, Tan TT, Hamamy H, Masri A, Shboul M, Al Saffar M, Partlow JN, Al-Dosari M, Alazami A, Alowain M, Alkuraya FS, Reiter JF, Harris MP, Reversade B, Walsh CA. Katanin p80 regulates human cortical development by limiting centriole and cilia number. Neuron. 2014 Dec 17; 84(6):1240-57. PMID: 25521379; PMCID: PMC4485387 [Available on 12/17/15].
    19. Ye X, Zeng H, Ning G, Reiter JF, Liu A. C2cd3 is critical for centriolar distal appendage assembly and ciliary vesicle docking in mammals. Proc Natl Acad Sci U S A. 2014 Feb 11; 111(6):2164-9. PMID: 24469809; PMCID: PMC3926046.
    20. Santos N, Reiter JF. A central region of Gli2 regulates its localization to the primary cilium and transcriptional activity. J Cell Sci. 2014 Apr 01; 127(Pt 7):1500-10. PMID: 24463817; PMCID: PMC3970560.
    21. de la Roche M, Ritter AT, Angus KL, Dinsmore C, Earnshaw CH, Reiter JF, Griffiths GM. Hedgehog signaling controls T cell killing at the immunological synapse. Science. 2013 Dec 06; 342(6163):1247-50. PMID: 24311692; PMCID: PMC4022134.
    22. Veniaminova NA, Vagnozzi AN, Kopinke D, Do TT, Murtaugh LC, Maillard I, Dlugosz AA, Reiter JF, Wong SY. Keratin 79 identifies a novel population of migratory epithelial cells that initiates hair canal morphogenesis and regeneration. Development. 2013 Dec; 140(24):4870-80. PMID: 24198274; PMCID: PMC3848186.
    23. D'Amico E, Gayral S, Massart C, Van Sande J, Reiter JF, Dumont JE, Robaye B, Schurmans S. Thyroid-specific inactivation of KIF3A alters the TSH signaling pathway and leads to hypothyroidism. J Mol Endocrinol. 2013 Jun; 50(3):375-87. PMID: 23511952; PMCID: PMC4404413.
    24. Kodani A, Salomé Sirerol-Piquer M, Seol A, Garcia-Verdugo JM, Reiter JF. Kif3a interacts with Dynactin subunit p150 Glued to organize centriole subdistal appendages. EMBO J. 2013 Feb 20; 32(4):597-607. PMID: 23386061; PMCID: PMC3579144.
    25. Spassov DS, Wong CH, Wong SY, Reiter JF, Moasser MM. Trask loss enhances tumorigenic growth by liberating integrin signaling and growth factor receptor cross-talk in unanchored cells. Cancer Res. 2013 Feb 01; 73(3):1168-79. PMID: 23243018; PMCID: PMC3563920.
    26. Wu VM, Chen SC, Arkin MR, Reiter JF. Small molecule inhibitors of Smoothened ciliary localization and ciliogenesis. Proc Natl Acad Sci U S A. 2012 Aug 21; 109(34):13644-9. PMID: 22864913; PMCID: PMC3427101.
    27. Reiter JF, Blacque OE, Leroux MR. The base of the cilium: roles for transition fibres and the transition zone in ciliary formation, maintenance and compartmentalization. EMBO Rep. 2012 Jun 29; 13(7):608-18. PMID: 22653444; PMCID: PMC3388784.
    28. Garcia-Gonzalo FR, Reiter JF. Scoring a backstage pass: mechanisms of ciliogenesis and ciliary access. J Cell Biol. 2012 Jun 11; 197(6):697-709. PMID: 22689651; PMCID: PMC3373398.
    29. Saqui-Salces M, Dowdle WE, Reiter JF, Merchant JL. A high-fat diet regulates gastrin and acid secretion through primary cilia. FASEB J. 2012 Aug; 26(8):3127-39. PMID: 22516298; PMCID: PMC3405261.
    30. Hunkapiller J, Shen Y, Diaz A, Cagney G, McCleary D, Ramalho-Santos M, Krogan N, Ren B, Song JS, Reiter JF. Polycomb-like 3 promotes polycomb repressive complex 2 binding to CpG islands and embryonic stem cell self-renewal. PLoS Genet. 2012; 8(3):e1002576. PMID: 22438827; PMCID: PMC3305387.
    31. Dowdle WE, Robinson JF, Kneist A, Sirerol-Piquer MS, Frints SG, Corbit KC, Zaghloul NA, Zaghloul NA, van Lijnschoten G, Mulders L, Verver DE, Zerres K, Reed RR, Attié-Bitach T, Johnson CA, García-Verdugo JM, Katsanis N, Bergmann C, Reiter JF. Disruption of a ciliary B9 protein complex causes Meckel syndrome. Am J Hum Genet. 2011 Jul 15; 89(1):94-110. PMID: 21763481; PMCID: PMC3135817.
    32. Garcia-Gonzalo FR, Corbit KC, Sirerol-Piquer MS, Ramaswami G, Otto EA, Noriega TR, Seol AD, Robinson JF, Bennett CL, Josifova DJ, García-Verdugo JM, Katsanis N, Hildebrandt F, Reiter JF. A transition zone complex regulates mammalian ciliogenesis and ciliary membrane composition. Nat Genet. 2011 Jul 03; 43(8):776-84. PMID: 21725307; PMCID: PMC3145011.
    33. Sang L, Miller JJ, Corbit KC, Giles RH, Brauer MJ, Otto EA, Baye LM, Wen X, Scales SJ, Kwong M, Huntzicker EG, Sfakianos MK, Sandoval W, Bazan JF, Kulkarni P, Garcia-Gonzalo FR, Seol AD, O'Toole JF, Held S, Reutter HM, Lane WS, Rafiq MA, Noor A, Ansar M, Devi AR, Sheffield VC, Slusarski DC, Vincent JB, Doherty DA, Hildebrandt F, Reiter JF, Jackson PK. Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. Cell. 2011 May 13; 145(4):513-28. PMID: 21565611; PMCID: PMC3383065.
    34. Croyle MJ, Lehman JM, O'Connor AK, Wong SY, Malarkey EB, Iribarne D, Dowdle WE, Schoeb TR, Verney ZM, Athar M, Michaud EJ, Reiter JF, Yoder BK. Role of epidermal primary cilia in the homeostasis of skin and hair follicles. Development. 2011 May; 138(9):1675-85. PMID: 21429982; PMCID: PMC3074444.
    35. Wong SY, Reiter JF. Wounding mobilizes hair follicle stem cells to form tumors. Proc Natl Acad Sci U S A. 2011 Mar 08; 108(10):4093-8. PMID: 21321207; PMCID: PMC3053984.
    36. Reiter JF. Crippling SWI-SNF makes tumors GLI-ful. Nat Med. 2010 Dec; 16(12):1374-6. PMID: 21135845.
      View in: PubMed
    37. Hunkapiller J, Singla V, Seol A, Reiter JF. The ciliogenic protein Oral-Facial-Digital 1 regulates the neuronal differentiation of embryonic stem cells. Stem Cells Dev. 2011 May; 20(5):831-41. PMID: 20873986; PMCID: PMC3128778.
    38. Santos N, Reiter JF. Tilting at nodal windmills: planar cell polarity positions cilia to tell left from right. Dev Cell. 2010 Jul 20; 19(1):5-6. PMID: 20643343; PMCID: PMC3998640.
    39. Reiter JF, de Sauvage FJ. Vive la science! Vive le hérisson! EMBO Rep. 2010 Aug; 11(8):566-8. PMID: 20634805; PMCID: PMC2920439.
    40. Singla V, Romaguera-Ros M, Garcia-Verdugo JM, Reiter JF. Ofd1, a human disease gene, regulates the length and distal structure of centrioles. Dev Cell. 2010 Mar 16; 18(3):410-24. PMID: 20230748; PMCID: PMC2841064.
    41. Walker E, Chang WY, Hunkapiller J, Cagney G, Garcha K, Torchia J, Krogan NJ, Reiter JF, Stanford WL. Polycomb-like 2 associates with PRC2 and regulates transcriptional networks during mouse embryonic stem cell self-renewal and differentiation. Cell Stem Cell. 2010 Feb 05; 6(2):153-66. PMID: 20144788; PMCID: PMC2849004.
    42. Singla V, Hunkapiller J, Santos N, Seol AD, Norman AR, Wakenight P, Skarnes WC, Reiter JF. Floxin, a resource for genetically engineering mouse ESCs. Nat Methods. 2010 Jan; 7(1):50-2. PMID: 19966808; PMCID: PMC2895430.
    43. Wong SY, Seol AD, So PL, Ermilov AN, Bichakjian CK, Epstein EH, Dlugosz AA, Reiter JF. Primary cilia can both mediate and suppress Hedgehog pathway-dependent tumorigenesis. Nat Med. 2009 Sep; 15(9):1055-61. PMID: 19701205; PMCID: PMC2895420.
    44. Aanstad P, Santos N, Corbit KC, Scherz PJ, Trinh le A, Salvenmoser W, Huisken J, Reiter JF, Stainier DY. The extracellular domain of Smoothened regulates ciliary localization and is required for high-level Hh signaling. Curr Biol. 2009 Jun 23; 19(12):1034-9. PMID: 19464178; PMCID: PMC2892286.
    45. Santos N, Reiter JF. Building it up and taking it down: the regulation of vertebrate ciliogenesis. Dev Dyn. 2008 Aug; 237(8):1972-81. PMID: 18435467; PMCID: PMC3304540.
    46. Reiter JF. A cilium is not a cilium is not a cilium: signaling contributes to ciliary morphological diversity. Dev Cell. 2008 May; 14(5):635-6. PMID: 18477443.
      View in: PubMed
    47. Gaulden J, Reiter JF. Neur-ons and neur-offs: regulators of neural induction in vertebrate embryos and embryonic stem cells. Hum Mol Genet. 2008 Apr 15; 17(R1):R60-6. PMID: 18632699.
      View in: PubMed
    48. Wong SY, Reiter JF. The primary cilium at the crossroads of mammalian hedgehog signaling. Curr Top Dev Biol. 2008; 85:225-60. PMID: 19147008; PMCID: PMC2653622.
    49. Corbit KC, Shyer AE, Dowdle WE, Gaulden J, Singla V, Chen MH, Chuang PT, Reiter JF. Kif3a constrains beta-catenin-dependent Wnt signalling through dual ciliary and non-ciliary mechanisms. Nat Cell Biol. 2008 Jan; 10(1):70-6. PMID: 18084282.
      View in: PubMed
    50. Reiter JF, Mostov K. Vesicle transport, cilium formation, and membrane specialization: the origins of a sensory organelle. Proc Natl Acad Sci U S A. 2006 Dec 05; 103(49):18383-4. PMID: 17132734; PMCID: PMC1693671.
    51. Singla V, Reiter JF. The primary cilium as the cell's antenna: signaling at a sensory organelle. Science. 2006 Aug 04; 313(5787):629-33. PMID: 16888132.
      View in: PubMed
    52. Reiter JF, Skarnes WC. Tectonic, a novel regulator of the Hedgehog pathway required for both activation and inhibition. Genes Dev. 2006 Jan 01; 20(1):22-7. PMID: 16357211; PMCID: PMC1356097.
    53. May SR, Ashique AM, Karlen M, Wang B, Shen Y, Zarbalis K, Reiter J, Ericson J, Peterson AS. Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli. Dev Biol. 2005 Nov 15; 287(2):378-89. PMID: 16229832.
      View in: PubMed
    54. Corbit KC, Aanstad P, Singla V, Norman AR, Stainier DY, Reiter JF. Vertebrate Smoothened functions at the primary cilium. Nature. 2005 Oct 13; 437(7061):1018-21. PMID: 16136078.
      View in: PubMed
    55. Kikuchi Y, Verkade H, Reiter JF, Kim CH, Chitnis AB, Kuroiwa A, Stainier DY. Notch signaling can regulate endoderm formation in zebrafish. Dev Dyn. 2004 Apr; 229(4):756-62. PMID: 15042699.
      View in: PubMed
    56. Reiter JF, Verkade H, Stainier DY. Bmp2b and Oep promote early myocardial differentiation through their regulation of gata5. Dev Biol. 2001 Jun 15; 234(2):330-8. PMID: 11397003.
      View in: PubMed
    57. Reiter JF, Kikuchi Y, Stainier DY. Multiple roles for Gata5 in zebrafish endoderm formation. Development. 2001 Jan; 128(1):125-35. PMID: 11092818.
      View in: PubMed
    58. Kikuchi Y, Trinh LA, Reiter JF, Alexander J, Yelon D, Stainier DY. The zebrafish bonnie and clyde gene encodes a Mix family homeodomain protein that regulates the generation of endodermal precursors. Genes Dev. 2000 May 15; 14(10):1279-89. PMID: 10817762; PMCID: PMC316618.
    59. Reiter JF, Alexander J, Rodaway A, Yelon D, Patient R, Holder N, Stainier DY. Gata5 is required for the development of the heart and endoderm in zebrafish. Genes Dev. 1999 Nov 15; 13(22):2983-95. PMID: 10580005; PMCID: PMC317161.
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