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Jonathan Singer, MD

TitleAssociate Professor
SchoolUCSF School of Medicine
DepartmentMedicine
Address505 Parnassus Avenue
San Francisco CA 94117
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    Collapse Biography 
    Collapse Education and Training
    University of California, San Francisco Residency School of Medicine
    University of California, San FranciscoM.D.2004School of Medicine
    University of California, BerkeleyM.S.2002 School of Public Health
    Stanford UniversityB.A.1999
    Collapse Awards and Honors
    UCSF2004Alpha Omega Alpha
    American Thoracic Society2008American Thoracic Society Critical Care Assembly Travel Award
    American Federation for Medical Research2009American Federation for Medical Research Scholar Award
    Breathe California2009Walter Travel Award
    Francis S. North Foundation2013North Senior Fellowship in Pulmonary Diseases
    American Thoracic Society2017American Thoracic Society Clinical Problems Assembly Early Career Achievement Award

    Collapse Overview 
    Collapse Overview
    Dr. Jonathan Singer is Assistant Professor of Medicine in the Division of Pulmonary, Critical Care, Allergy and Sleep Medicine. He serves as an attending physician in the Lung Transplant Program, where he cares for patients with advanced lung disease before and after lung transplantation. Dr. Singer received his undergraduate degree from Stanford University and a Masters in Health and Medical Sciences from the School of Public Health at UC Berkeley. He received his medical degree from the UC San Francisco School of Medicine. Dr. Singer remained at UC San Francisco, where he completed a residency in Internal Medicine, a fellowships in Pulmonary and Critical Care Medicine and Lung/Heart-Lung Transplantation. He is board certified in Internal Medicine, Pulmonary Medicine and Critical Care Medicine. He is a member of the American Thoracic Society, International Society for Heart and Lung transplantation, American College of Chest Physicians and European Respiratory Society.

    He is Associate Medical Director of Lung Transplant Outcomes Research and is a core investigator with the UCSF Respiratory Epidemiology Group. He has served as Chair of the International Society of Heart and Lung Transplantation Pulmonary Council Quality of Life Workforce since 2012. His research focuses broadly on how lung transplantation improves patient-centered outcomes including functioning, disability, health-related quality of life, and survival. An area of particular interest is how frailty and refined assessments of body composition impact patient-centered outcomes in lung transplant candidates and recipients.


    Collapse Research 
    Collapse Research Activities and Funding
    Frailty and patient centered outcomes in candidates for lung transplantation
    NIH/NHLBI R01HL134851Jul 1, 2017 - Jun 30, 2022
    Role: Principal Investigator
    The Effects of Lung Transplant on Disability and Health-Related Quality of Life
    NIH/NHLBI K23HL111115Sep 1, 2012 - Aug 31, 2017
    Role: Principal Investigator
    The effects of lung transplantation on lung disease related disabilities
    NIH/NHLBI F32HL107003Jun 30, 2011 - Jun 29, 2012
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Singer JP. Pulmonary Hypertension and Primary Graft Dysfunction in Lung Transplant Recipients: We Still Have a Long Way to Go. Ann Am Thorac Soc. 2017 Oct; 14(10):1504-1505. PMID: 28961030.
      View in: PubMed
    2. Layton AM, Armstrong HF, Baldwin MR, Podolanczuk AJ, Pieszchata NM, Singer JP, Arcasoy SM, Meza KS, D'Ovidio F, Lederer DJ. Frailty and maximal exercise capacity in adult lung transplant candidates. Respir Med. 2017 Oct; 131:70-76. PMID: 28947046.
      View in: PubMed
    3. Baldwin MR, Singer J, Huang D, Sell J, Gonzalez WC, Pollack L, Maurer MS, D'Ovidio FF, Bacchetta M, Sonett JR, Arcasoy SM, Shah L, Robbins H, Hays SR, Kukreja J, Greenland JR, Shah RJ, Leard L, Morrell M, Gries C, Katz PP, Christie JD, Diamond JM, Lederer DJ. Refining Low Physical Activity Measurement Improves Frailty Assessment in Advanced Lung Disease and Survivors of Critical Illness. Ann Am Thorac Soc. 2017 Aug; 14(8):1270-1279. PMID: 28398076.
      View in: PubMed
    4. Diamond JM, Arcasoy S, Kennedy CC, Eberlein M, Singer JP, Patterson GM, Edelman JD, Dhillon G, Pena T, Kawut SM, Lee JC, Girgis R, Dark J, Thabut G. Report of the International Society for Heart and Lung Transplantation Working Group on Primary Lung Graft Dysfunction, part II: Epidemiology, risk factors, and outcomes-A 2016 Consensus Group statement of the International Society for Heart and Lung Transplantation. J Heart Lung Transplant. 2017 Oct; 36(10):1104-1113. PMID: 28802530.
      View in: PubMed
    5. Greenland JR, Sun H, Calabrese D, Chong T, Singer J, Kukreja J, Hays SR, Golden JA, Caughey GH, Venstrom JM, Rajalinginam R. HLA Mismatching Favoring Host-Versus-Graft NK Cell Activity Via KIR3DL1 Is Associated With Improved Outcomes Following Lung Transplantation. Am J Transplant. 2017 Aug; 17(8):2192-2199. PMID: 28375571.
      View in: PubMed
    6. Faust HE, Golden JA, Rajalingam R, Wang AS, Green G, Hays SR, Kukreja J, Singer J, Wolters PJ, Greenland JR. Short lung transplant donor telomere length is associated with decreased CLAD-free survival. Thorax. 2017 Apr 26. PMID: 28446663.
      View in: PubMed
    7. Singer JP, Katz PP, Soong A, Shrestha P, Huang D, Ho J, Mindo M, Greenland JR, Hays SR, Golden J, Kukreja J, Kleinhenz ME, Shah RJ, Blanc PD. Effect of Lung Transplantation on Health-Related Quality of Life in the Era of the Lung Allocation Score: A U.S. Prospective Cohort Study. Am J Transplant. 2017 May; 17(5):1334-1345. PMID: 27743488.
      View in: PubMed
    8. Greenland JR, Wong CM, Ahuja R, Wang AS, Uchida C, Golden JA, Hays SR, Leard LE, Rajalingam R, Singer J, Kukreja J, Wolters PJ, Caughey GH, Tang Q. Donor-Reactive Regulatory T Cell Frequency Increases During Acute Cellular Rejection of Lung Allografts. Transplantation. 2016 Oct; 100(10):2090-8. PMID: 27077597.
      View in: PubMed
    9. Singer J, Lederer DJ, Baldwin MR. Frailty in Pulmonary and Critical Care Medicine. Ann Am Thorac Soc. 2016 Aug; 13(8):1394-404. PMID: 27104873; PMCID: PMC5021078 [Available on 08/01/17].
    10. Garrett GL, Lowenstein SE, Singer J, He SY, Arron ST. Trends of skin cancer mortality after transplantation in the United States: 1987 to 2013. J Am Acad Dermatol. 2016 Jul; 75(1):106-12. PMID: 27067869.
      View in: PubMed
    11. Singer J, Diamond JM, Gries CJ, McDonnough J, Blanc PD, Shah R, Dean MY, Hersh B, Wolters PJ, Tokman S, Arcasoy SM, Ramphal K, Greenland JR, Smith N, Heffernan P, Shah L, Shrestha P, Golden JA, Blumenthal NP, Huang D, Sonett J, Hays S, Oyster M, Katz PP, Robbins H, Brown M, Leard LE, Kukreja J, Bacchetta M, Bush E, D'Ovidio F, Rushefski M, Raza K, Christie JD, Lederer DJ. Frailty Phenotypes, Disability, and Outcomes in Adult Candidates for Lung Transplantation. Am J Respir Crit Care Med. 2015 Dec 01; 192(11):1325-34. PMID: 26258797; PMCID: PMC4731703 [Available on 12/01/16].
    12. Tokman S, Hays SR, Leard LE, Bush EL, Kukreja J, Kleinhenz ME, Golden JA, Singer JP. Prolonged Barium-Impaction Ileus in Two Lung Transplant Recipients With Systemic Sclerosis: Case Report. Transplant Proc. 2015 Dec; 47(10):2965-7. PMID: 26707322.
      View in: PubMed
    13. Mansh M, Binstock M, Williams K, Hafeez F, Kim J, Glidden D, Boettger R, Hays S, Kukreja J, Golden J, Asgari MM, Chin-Hong P, Singer J, Arron ST. Voriconazole Exposure and Risk of Cutaneous Squamous Cell Carcinoma, Aspergillus Colonization, Invasive Aspergillosis and Death in Lung Transplant Recipients. Am J Transplant. 2016 Jan; 16(1):262-70. PMID: 26372838; PMCID: PMC4718897 [Available on 01/01/17].
    14. Kern RM, Singer JP, Koth L, Mooney J, Golden J, Hays S, Greenland J, Wolters P, Ghio E, Jones KD, Leard L, Kukreja J, Blanc PD. Lung transplantation for hypersensitivity pneumonitis. Chest. 2015 Jun; 147(6):1558-1565. PMID: 25412059; PMCID: PMC4451710.
    15. Tokman S, Singer J, Devine MS, Westall GP, Aubert JD, Tamm M, Snell GI, Lee JS, Goldberg HJ, Kukreja J, Golden JA, Leard LE, Garcia CK, Hays SR. Clinical outcomes of lung transplant recipients with telomerase mutations. J Heart Lung Transplant. 2015 Oct; 34(10):1318-24. PMID: 26169663.
      View in: PubMed
    16. He SY, Makhzoumi ZH, Singer JP, Chin-Hong PV, Arron ST. Practice variation in Aspergillus prophylaxis and treatment among lung transplant centers: a national survey. Transpl Infect Dis. 2015 Feb; 17(1):14-20. PMID: 25620387.
      View in: PubMed
    17. Singer JP, Chen J, Katz PP, Blanc PD, Kagawa-Singer M, Stewart AL. Defining novel health-related quality of life domains in lung transplantation: a qualitative analysis. Qual Life Res. 2015 Jun; 24(6):1521-33. PMID: 25471287; PMCID: PMC4456337.
    18. Singer JP, Peterson ER, Snyder ME, Katz PP, Golden JA, D'Ovidio F, Bacchetta M, Sonett JR, Kukreja J, Shah L, Robbins H, Van Horn K, Shah RJ, Diamond JM, Wickersham N, Sun L, Hays S, Arcasoy SM, Palmer SM, Ware LB, Christie JD, Lederer DJ. Body composition and mortality after adult lung transplantation in the United States. Am J Respir Crit Care Med. 2014 Nov 01; 190(9):1012-21. PMID: 25233138; PMCID: PMC4299586.
    19. Hui C, Kern R, Wojciechowski D, Kukreja J, Golden JA, Hays SR, Singer JP. Belatacept for Maintenance Immunosuppression in Lung Transplantation. J Investig Med High Impact Case Rep. 2014 Jul-Sep; 2(3):2324709614546866. PMID: 26425619; PMCID: PMC4528899.
    20. Kern RM, Seethamraju H, Blanc PD, Sinha N, Loebe M, Golden J, Kukreja J, Scheinin S, Hays S, Kleinhenz ME, Leard L, Hoopes C, Singer JP. The feasibility of lung transplantation in HIV-seropositive patients. Ann Am Thorac Soc. 2014 Jul; 11(6):882-9. PMID: 24964265; PMCID: PMC4213997.
    21. Richardson CB, Singer JP. Lung Transplantation for Scleroderma-related Lung Disease. Curr Respir Care Rep. 2014 Sep; 3(3):79-87. PMID: 27833787.
      View in: PubMed
    22. Ware LB, Landeck M, Koyama T, Zhao Z, Singer J, Kern R, Neidlinger N, Nguyen J, Johnson E, Janz DR, Bernard GR, Lee JW, Matthay MA. A randomized trial of the effects of nebulized albuterol on pulmonary edema in brain-dead organ donors. Am J Transplant. 2014 Mar; 14(3):621-8. PMID: 24730050; PMCID: PMC3986821.
    23. Greenland JR, Jewell NP, Gottschall M, Trivedi NN, Kukreja J, Hays SR, Singer JP, Golden JA, Caughey GH. Bronchoalveolar lavage cell immunophenotyping facilitates diagnosis of lung allograft rejection. Am J Transplant. 2014 Apr; 14(4):831-40. PMID: 24512389; PMCID: PMC4300200.
    24. Hui C, Kern RM, Wojciechowski D, Kukreja J, Golden JA, Hays SR, Singer J . Use of Belatacept in a Lung Transplant Recipient. J Invest Med High Impact Case Reports. 2014; (Jul-Sept):1-3.
    25. Williams K, Mansh M, Chin-Hong P, Singer J, Arron ST. Voriconazole-associated cutaneous malignancy: a literature review on photocarcinogenesis in organ transplant recipients. Clin Infect Dis. 2014 Apr; 58(7):997-1002. PMID: 24363331.
      View in: PubMed
    26. Singer JP, Blanc PD, Dean YM, Hays S, Leard L, Kukreja J, Golden J, Katz PP. Development and validation of a lung transplant-specific disability questionnaire. Thorax. 2014 May; 69(5):437-42. PMID: 24355825; PMCID: PMC4113506.
    27. Singer JP, Singer LG. Quality of life in lung transplantation. Semin Respir Crit Care Med. 2013 Jun; 34(3):421-30. PMID: 23821515; PMCID: PMC4238962.
    28. Sottile PD, Iturbe D, Katsumoto TR, Connolly MK, Collard HR, Leard LA, Hays S, Golden JA, Hoopes C, Kukreja J, Singer JP. Outcomes in systemic sclerosis-related lung disease after lung transplantation. Transplantation. 2013 Apr 15; 95(7):975-80. PMID: 23545509; PMCID: PMC3616420.
    29. Singer JP, Chen J, Blanc PD, Leard LE, Kukreja J, Chen H. A thematic analysis of quality of life in lung transplant: the existing evidence and implications for future directions. Am J Transplant. 2013 Apr; 13(4):839-50. PMID: 23432992; PMCID: PMC3622720.
    30. Sayah DM, Schwartz BS, Kukreja J, Singer JP, Golden JA, Leard LE. Scedosporium prolificans pericarditis and mycotic aortic aneurysm in a lung transplant recipient receiving voriconazole prophylaxis. Transpl Infect Dis. 2013 Apr; 15(2):E70-4. PMID: 23387799.
      View in: PubMed
    31. Sayah DM, Koff JL, Leard LE, Hays SR, Golden JA, Singer JP. Rhinovirus and other respiratory viruses exert different effects on lung allograft function that are not mediated through acute rejection. Clin Transplant. 2013 Jan-Feb; 27(1):E64-71. PMID: 23278569; PMCID: PMC3558613.
    32. Singer JP, Yusen RD. Defining patient-reported outcomes in chronic obstructive pulmonary disease: the patient-centered experience. Med Clin North Am. 2012 Jul; 96(4):767-87. PMID: 22793944.
      View in: PubMed
    33. Singer JP, Katz PP, Iribarren C, Omachi TA, Sanchez G, Yelin EH, Cisternas MG, Blanc PD. Both pulmonary and extra-pulmonary factors predict the development of disability in chronic obstructive pulmonary disease. Respiration. 2013; 85(5):375-83. PMID: 22688324; PMCID: PMC3939058.
    34. Zutler M, Singer JP, Omachi TA, Eisner M, Iribarren C, Katz P, Blanc PD. Relationship of obesity with respiratory symptoms and decreased functional capacity in adults without established COPD. Prim Care Respir J. 2012 Jun; 21(2):194-201. PMID: 22453663; PMCID: PMC3523806.
    35. Singer JP, Boker A, Metchnikoff C, Binstock M, Boettger R, Golden JA, Glidden DV, Arron ST. High cumulative dose exposure to voriconazole is associated with cutaneous squamous cell carcinoma in lung transplant recipients. J Heart Lung Transplant. 2012 Jul; 31(7):694-9. PMID: 22484291; PMCID: PMC3371090.
    36. Wiita AP, Roubinian N, Khan Y, Chin-Hong PV, Singer JP, Golden JA, Miller S. Cytomegalovirus disease and infection in lung transplant recipients in the setting of planned indefinite valganciclovir prophylaxis. Transpl Infect Dis. 2012 Jun; 14(3):248-58. PMID: 22385394.
      View in: PubMed
    37. Metchnikoff C, Mully T, Singer JP, Golden JA, Arron ST. The 7th edition AJCC staging system for cutaneous squamous cell carcinoma accurately predicts risk of recurrence for heart and lung transplant recipients. J Am Acad Dermatol. 2012 Nov; 67(5):829-35. PMID: 22285618; PMCID: PMC3345300.
    38. Watkins KD, Boettger RF, Hanger KM, Leard LE, Golden JA, Hoopes CW, Singer JP. Use of sublingual tacrolimus in lung transplant recipients. J Heart Lung Transplant. 2012 Feb; 31(2):127-32. PMID: 22177691.
      View in: PubMed
    39. Smith L, Singer JP, Hayes M, Golden JA, Leard LE. An analysis of potential risk factors for early complications from fiberoptic bronchoscopy in lung transplant recipients. Transpl Int. 2012 Feb; 25(2):172-8. PMID: 22151411.
      View in: PubMed
    40. Singer JP, Chen H, Phelan T, Kukreja J, Golden JA, Blanc PD. Survival following lung transplantation for silicosis and other occupational lung diseases. Occup Med (Lond). 2012 Mar; 62(2):134-7. PMID: 22071439; PMCID: PMC3283165.
    41. Singer JP, Blanc PD, Hoopes C, Golden JA, Koff JL, Leard LE, Cheng S, Chen H. The impact of pretransplant mechanical ventilation on short- and long-term survival after lung transplantation. Am J Transplant. 2011 Oct; 11(10):2197-204. PMID: 21831157; PMCID: PMC4249721.
    42. Singer J, Yelin EH, Katz PP, Sanchez G, Iribarren C, Eisner MD, Blanc PD. Respiratory and skeletal muscle strength in chronic obstructive pulmonary disease: impact on exercise capacity and lower extremity function. J Cardiopulm Rehabil Prev. 2011 Mar-Apr; 31(2):111-9. PMID: 21240003; PMCID: PMC3085880.
    43. Ibrahim SF, Singer JP, Arron ST. Catastrophic squamous cell carcinoma in lung transplant patients treated with voriconazole. Dermatol Surg. 2010 Nov; 36(11):1752-5. PMID: 20533939; PMCID: PMC3046628.
    44. Singer JP, Kohlwes J, Bent S, Zimmerman L, Eisner MD. The impact of a "low-intensity" versus "high-intensity" medical intensive care unit on patient outcomes in critically ill veterans. J Intensive Care Med. 2010 Jul; 25(4):233-9. PMID: 20444736; PMCID: PMC3577353.
    45. Singer JP, Huang MY, Hui C, Blanc PD, Boettger RF, Golden J, Watkins K, Hoopes C, Leard LE. Supratherapeutic anticoagulation from low-molecular-weight heparin in lung transplant recipients. J Heart Lung Transplant. 2010 Sep; 29(9):1009-13. PMID: 20627627; PMCID: PMC3045833.
    46. Lord RV, Park JM, Wickramasinghe K, DeMeester SR, Oberg S, Salonga D, Singer J, Peters JH, Danenberg KD, Demeester TR, Danenberg PV. Vascular endothelial growth factor and basic fibroblast growth factor expression in esophageal adenocarcinoma and Barrett esophagus. J Thorac Cardiovasc Surg. 2003 Feb; 125(2):246-53. PMID: 12579092.
      View in: PubMed
    47. Brabender J, Usadel H, Danenberg KD, Metzger R, Schneider PM, Lord RV, Wickramasinghe K, Lum CE, Park J, Salonga D, Singer J, Sidransky D, H├Âlscher AH, Meltzer SJ, Danenberg PV. Adenomatous polyposis coli gene promoter hypermethylation in non-small cell lung cancer is associated with survival. Oncogene. 2001 Jun 14; 20(27):3528-32. PMID: 11429699.
      View in: PubMed
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