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    Zev Gartner, PhD

    TitleAssociate Professor
    SchoolUCSF School of Pharmacy
    DepartmentPharmaceutical Chemistry
    Address600 16th Street
    San Francisco CA 94158
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      Collapse Biography 
      Collapse Education and Training
      UC BerkeleyB.S.Chemistry1999
      Harvard UniversityPh.D.Chemistry2004
      UC BerkeleyPost DoctoralChemistry2008
      Collapse Awards and Honors
      1998 - 1998Beckman Scholar
      UC Berkeley1999 - 1999High Honors in Chemistry
      National Science Foundation Graduate Research2000 - 2000Fellowship
      Bristol-Myers Squibb2003 - 2003Fellowship
      Harvard2003 - 2003Merit Fellowship
      2005 - 2005IUPAC Prize for Young Chemists "for the best Ph.D. theses in the chemical sciences."
      2006 - 2006Jane Coffin Childs Postdoctoral Fellow
      2008 - 2008Sandler Opportunity Award
      2010 - 2010Kimmel Scholar Award
      2010 - 2010Era of Hope Scholar Award
      NIH2013New Innovator Award
      Popular Science2015Brilliant 10

      Collapse Overview 
      Collapse Overview
      The human body contains over 10 trillion cells spanning hundreds of morphologically distinct cell types. These cells must work together for our bodies to function correctly. However, it remains a mystery how such an enormous diversity of cells coordinate their behaviors.

      Tissue structure - or the composition and physical arrangement of cells, extracellular matrix, and diffusible molecules - helps to coordinate cellular behaviors by organizing the flow of chemical, mechanical, and electrical information between cells. Thus, building tissue structure correctly and maintaining tissue structure over time are prerequisites for engineering functional organs and stopping the progression of diseases like cancer.

      We are interested in three general questions about how tissue structure forms and functions:

      (i) How does tissue structure form through the process of self-organization?
      (ii) How does tissue structure help cells to arrive at collective decisions and to organize collective behaviors?
      (iii) How does tissue structure breakdown during the progression of diseases like cancer?

      To answer these questions we take a synthetic approach, building human tissues from the bottom-up. This approach allows us to measure and perturb the molecular and physical properties of individual cells, reconstitute them into living tissue, then observe their interactions to reveal the underlying "rules" guiding their collective behaviors. We focus primarily on the cells and tissues of the human breast, and our work incorporates experimental principles from the chemical, biological, and engineering sciences.

      Collapse Interests
      Chemical Biology, Tissue Engineering, Systems and Synthetic Biology, Cancer Biology

      Collapse ORNG Applications 
      Collapse Websites
      Collapse In The News
      Collapse Featured Publications

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Ouyang A, Cerchiari AE, Tang X, Liebenberg E, Alliston T, Gartner ZJ, Lotz JC. Effects of cell type and configuration on anabolic and catabolic activity in 3D co-culture of mesenchymal stem cells and nucleus pulposus cells. J Orthop Res. 2016 Oct 4. PMID: 27699833.
        View in: PubMed
      2. Cerchiari AE, Samy KE, Todhunter ME, Schlesinger E, Henise J, Rieken C, Gartner ZJ, Desai TA. Probing the luminal microenvironment of reconstituted epithelial microtissues. Sci Rep. 2016; 6:33148. PMID: 27619235.
        View in: PubMed
      3. Todhunter ME, Weber RJ, Farlow J, Jee NY, Cerchiari AE, Gartner ZJ. Fabrication of 3-D Reconstituted Organoid Arrays by DNA-Programmed Assembly of Cells (DPAC). Curr Protoc Chem Biol. 2016; 8(3):147-78. PMID: 27622567.
        View in: PubMed
      4. Seo D, Southard KM, Kim JW, Lee HJ, Farlow J, Lee JU, Litt DB, Haas T, Alivisatos AP, Cheon J, Gartner ZJ, Jun YW. A Mechanogenetic Toolkit for Interrogating Cell Signaling in Space and Time. Cell. 2016 Jun 2; 165(6):1507-18. PMID: 27180907.
        View in: PubMed
      5. Cole RH, Gartner ZJ, Abate AR. Multicolor Fluorescence Detection for Droplet Microfluidics Using Optical Fibers. J Vis Exp. 2016; (111). PMID: 27214249.
        View in: PubMed
      6. Coyle M, Hu J, Gartner Z. Mysteries in a Minimal Genome. ACS Cent Sci. 2016 May 25; 2(5):274-7. PMID: 27280161.
        View in: PubMed
      7. Broaders KE, Cerchiari AE, Gartner ZJ. Coupling between apical tension and basal adhesion allow epithelia to collectively sense and respond to substrate topography over long distances. Integr Biol (Camb). 2015 Dec 30; 7(12):1611-21. PMID: 26507156; PMCID: PMC4666816 [Available on 12/30/16].
      8. Todhunter ME, Jee NY, Hughes AJ, Coyle MC, Cerchiari A, Farlow J, Garbe JC, LaBarge MA, Desai TA, Gartner ZJ. Programmed synthesis of three-dimensional tissues. Nat Methods. 2015 Oct; 12(10):975-81. PMID: 26322836; PMCID: PMC4589502 [Available on 04/01/16].
      9. Cole RH, de Lange N, Gartner ZJ, Abate AR. Compact and modular multicolour fluorescence detector for droplet microfluidics. Lab Chip. 2015 Jul 7; 15(13):2754-8. PMID: 26032595; PMCID: PMC4505729.
      10. Cerchiari AE, Garbe JC, Jee NY, Todhunter ME, Broaders KE, Peehl DM, Desai TA, LaBarge MA, Thomson M, Gartner ZJ. A strategy for tissue self-organization that is robust to cellular heterogeneity and plasticity. Proc Natl Acad Sci U S A. 2015 Feb 17; 112(7):2287-92. PMID: 25633040; PMCID: PMC4343104.
      11. Cerchiari A, Garbe JC, Todhunter ME, Jee NY, Pinney JR, LaBarge MA, Desai TA, Gartner ZJ. Formation of spatially and geometrically controlled three-dimensional tissues in soft gels by sacrificial micromolding. Tissue Eng Part C Methods. 2015 Jun; 21(6):541-7. PMID: 25351430; PMCID: PMC4442595 [Available on 06/01/16].
      12. Weber RJ, Liang SI, Selden NS, Desai TA, Gartner ZJ. Efficient targeting of fatty-acid modified oligonucleotides to live cell membranes through stepwise assembly. Biomacromolecules. 2014 Dec 8; 15(12):4621-6. PMID: 25325667; PMCID: PMC4261982.
      13. Seo D, Farlow J, Southard K, Jun YW, Gartner ZJ. Production and targeting of monovalent quantum dots. J Vis Exp. 2014; (92):e52198. PMID: 25407345; PMCID: PMC4309134.
      14. Liang SI, McFarland JM, Rabuka D, Gartner ZJ. A modular approach for assembling aldehyde-tagged proteins on DNA scaffolds. J Am Chem Soc. 2014 Aug 6; 136(31):10850-3. PMID: 25029632; PMCID: PMC4132959.
      15. Rosenblatt J, Gartner Z. Cells: Shaping tissues and organs. Mol Biol Cell. 2014 Mar; 25(6):730. PMID: 24626844; PMCID: PMC3952838.
      16. Farlow J, Seo D, Broaders KE, Taylor MJ, Gartner ZJ, Jun YW. Formation of targeted monovalent quantum dots by steric exclusion. Nat Methods. 2013 Dec; 10(12):1203-5. PMID: 24122039; PMCID: PMC3968776.
      17. Sogi KM, Gartner ZJ, Breidenbach MA, Appel MJ, Schelle MW, Bertozzi CR. Mycobacterium tuberculosis Rv3406 is a type II alkyl sulfatase capable of sulfate scavenging. PLoS One. 2013; 8(6):e65080. PMID: 23762287; PMCID: PMC3675115.
      18. Liu JS, Gartner ZJ. Directing the assembly of spatially organized multicomponent tissues from the bottom up. Trends Cell Biol. 2012 Dec; 22(12):683-91. PMID: 23067679; PMCID: PMC3505240.
      19. Liu JS, Farlow JT, Paulson AK, Labarge MA, Gartner ZJ. Programmed cell-to-cell variability in Ras activity triggers emergent behaviors during mammary epithelial morphogenesis. Cell Rep. 2012 Nov 29; 2(5):1461-70. PMID: 23041312; PMCID: PMC3634587.
      20. Onoe H, Hsiao SC, Douglas ES, Gartner ZJ, Bertozzi CR, Francis MB, Mathies RA. Cellular microfabrication: observing intercellular interactions using lithographically-defined DNA capture sequences. Langmuir. 2012 May 29; 28(21):8120-6. PMID: 22512362.
        View in: PubMed
      21. Selden NS, Todhunter ME, Jee NY, Liu JS, Broaders KE, Gartner ZJ. Chemically programmed cell adhesion with membrane-anchored oligonucleotides. J Am Chem Soc. 2012 Jan 18; 134(2):765-8. PMID: 22176556; PMCID: PMC3280587.
      22. Hsiao SC, Shum BJ, Onoe H, Douglas ES, Gartner ZJ, Mathies RA, Bertozzi CR, Francis MB. Direct cell surface modification with DNA for the capture of primary cells and the investigation of myotube formation on defined patterns. Langmuir. 2009 Jun 16; 25(12):6985-91. PMID: 19505164; PMCID: PMC2812030.
      23. Gartner ZJ, Bertozzi CR. Programmed assembly of 3-dimensional microtissues with defined cellular connectivity. Proc Natl Acad Sci U S A. 2009 Mar 24; 106(12):4606-10. PMID: 19273855; PMCID: PMC2660766.
      24. Chen X, Wu P, Rousseas M, Okawa D, Gartner Z, Zettl A, Bertozzi CR. Boron nitride nanotubes are noncytotoxic and can be functionalized for interaction with proteins and cells. J Am Chem Soc. 2009 Jan 28; 131(3):890-1. PMID: 19119844; PMCID: PMC2657038.
      25. Gartner ZJ, Tse BN, Grubina R, Doyon JB, Snyder TM, Liu DR. DNA-templated organic synthesis and selection of a library of macrocycles. Science. 2004 Sep 10; 305(5690):1601-5. PMID: 15319493; PMCID: PMC2814051.
      26. Buskirk AR, Ong YC, Gartner ZJ, Liu DR. Directed evolution of ligand dependence: small-molecule-activated protein splicing. Proc Natl Acad Sci U S A. 2004 Jul 20; 101(29):10505-10. PMID: 15247421; PMCID: PMC489967.
      27. Li X, Gartner ZJ, Tse BN, Liu DR. Translation of DNA into synthetic N-acyloxazolidines. J Am Chem Soc. 2004 Apr 28; 126(16):5090-2. PMID: 15099091.
        View in: PubMed
      28. Gartner ZJ, Grubina R, Calderone CT, Liu DR. Two enabling architectures for DNA-templated organic synthesis. Angew Chem Int Ed Engl. 2003 Mar 28; 42(12):1370-5. PMID: 12671971.
        View in: PubMed
      29. Calderone CT, Puckett JW, Gartner ZJ, Liu DR. Directing otherwise incompatible reactions in a single solution by using DNA-templated organic synthesis. Angew Chem Int Ed Engl. 2002 Nov 4; 41(21):4104-8. PMID: 12412096.
        View in: PubMed
      30. Gartner ZJ, Kanan MW, Liu DR. Multistep small-molecule synthesis programmed by DNA templates. J Am Chem Soc. 2002 Sep 4; 124(35):10304-6. PMID: 12197733.
        View in: PubMed
      31. Gartner ZJ, Kanan MW, Liu DR. Expanding the reaction scope of DNA-templated synthesis. Angew Chem Int Ed Engl. 2002 May 17; 41(10):1796-800. PMID: 19750721.
        View in: PubMed
      32. Gartner ZJ, Liu DR. The generality of DNA-templated synthesis as a basis for evolving non-natural small molecules. J Am Chem Soc. 2001 Jul 18; 123(28):6961-3. PMID: 11448217; PMCID: PMC2820563.
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