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    Jacquelyn Maher, MD

    SchoolUCSF School of Medicine
    Address1001 Potrero Ave, SFGH 40
    San Francisco CA 94110
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      Collapse Biography 
      Collapse Education and Training
      Duke University School of MedicineM.D.1979
      Duke University Medical CenterResidency Internal Medicine1983
      University of California, San FranciscoFellowshipGastroenterology1987

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      Collapse Overview
      BA: Duke University
      MD: Duke University School of Medicine
      Residency: Duke University Medical Center, Internal Medicine
      Fellowship: University of California, San Francisco, Gastroenterology


      Dr. Maher is Chief of the Division of Gastroenterology at San Francisco General Hospital and Director of the UCSF Liver Center. Research in her laboratory focuses on the pathogenesis of fatty liver disease. Special emphasis is placed on the effects of individual dietary macronutrients on liver injury. Her studies in mice implicate dietary sugar as an important inducer of fatty liver disease, through conversion to toxic saturated fatty acids. Ongoing work in her group concentrates on the synergistic toxicity of dietary sugar and saturated fat. Experiments also focus on the mechanism by which saturated fatty acids kill liver cells.

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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Pierce AA, Pickens MK, Siao K, Grenert JP, Maher JJ. Differential hepatotoxicity of dietary and DNL-derived palmitate in the methionine-choline-deficient model of steatohepatitis. BMC Gastroenterol. 2015; 15:72.
        View in: PubMed
      2. Mattis AN, Song G, Hitchner K, Kim RY, Lee AY, Sharma AD, Malato Y, McManus MT, Esau CC, Koller E, Koliwad S, Lim LP, Maher JJ, Raffai RL, Willenbring H. A screen in mice uncovers repression of lipoprotein lipase by microRNA-29a as a mechanism for lipid distribution away from the liver. Hepatology. 2015 Jan; 61(1):141-52.
        View in: PubMed
      3. Duwaerts CC, Maher JJ. Mechanisms of Liver Injury in Non-Alcoholic Steatohepatitis. Curr Hepatol Rep. 2014 Jun 1; 13(2):119-129.
        View in: PubMed
      4. Kamalakar A, Bendre MS, Washam CL, Fowler TW, Carver A, Dilley JD, Bracey JW, Akel NS, Margulies AG, Skinner RA, Swain FL, Hogue WR, Montgomery CO, Lahiji P, Maher JJ, Leitzel KE, Ali SM, Lipton A, Nicholas RW, Gaddy D, Suva LJ. Circulating interleukin-8 levels explain breast cancer osteolysis in mice and humans. Bone. 2014 Apr; 61:176-85.
        View in: PubMed PMC3967592
      5. Henderson NC, Arnold TD, Katamura Y, Giacomini MM, Rodriguez JD, McCarty JH, Pellicoro A, Raschperger E, Betsholtz C, Ruminski PG, Griggs DW, Prinsen MJ, Maher JJ, Iredale JP, Lacy-Hulbert A, Adams RH, Sheppard D. Targeting of av integrin identifies a core molecular pathway that regulates fibrosis in several organs. Nat Med. 2013 Dec; 19(12):1617-24.
        View in: PubMed PMC3855865
      6. Wei K, Piecewicz SM, McGinnis LM, Taniguchi CM, Wiegand SJ, Anderson K, Chan CW, Mulligan KX, Kuo D, Yuan J, Vallon M, Morton LC, Lefai E, Simon MC, Maher JJ, Mithieux G, Rajas F, Annes JP, McGuinness OP, Thurston G, Giaccia AJ, Kuo CJ. A liver Hif-2a-Irs2 pathway sensitizes hepatic insulin signaling and is modulated by Vegf inhibition. Nat Med. 2013 Oct; 19(10):1331-7.
        View in: PubMed PMC3795838
      7. Maher JJ. Retinol binding protein 4 and fatty liver: A direct link? Hepatology. 2013 Aug; 58(2):477-9.
        View in: PubMed PMC3729862
      8. Varenika V, Fu Y, Maher JJ, Gao D, Kakar S, Cabarrus MC, Yeh BM. Hepatic fibrosis: evaluation with semiquantitative contrast-enhanced CT. Radiology. 2013 Jan; 266(1):151-8.
        View in: PubMed PMC3528968
      9. Mukhtar NA, Bacchetti P, Ayala CE, Melgar J, Christensen S, Maher JJ, Khalili M. Insulin sensitivity and variability in hepatitis C virus infection using direct measurement. Dig Dis Sci. 2013 Apr; 58(4):1141-8.
        View in: PubMed PMC3566265
      10. Yin C, Evason KJ, Maher JJ, Stainier DY. The basic helix-loop-helix transcription factor, heart and neural crest derivatives expressed transcript 2, marks hepatic stellate cells in zebrafish: analysis of stellate cell entry into the developing liver. Hepatology. 2012 Nov; 56(5):1958-70.
        View in: PubMed PMC3407311
      11. Nie B, Park HM, Kazantzis M, Lin M, Henkin A, Ng S, Song S, Chen Y, Tran H, Lai R, Her C, Maher JJ, Forman BM, Stahl A. Specific bile acids inhibit hepatic fatty acid uptake in mice. Hepatology. 2012 Oct; 56(4):1300-10.
        View in: PubMed PMC3445775
      12. Brandman D, Bacchetti P, Ayala CE, Maher JJ, Khalili M. Impact of insulin resistance on HCV treatment response and impact of HCV treatment on insulin sensitivity using direct measurements of insulin action. Diabetes Care. 2012 May; 35(5):1090-4.
        View in: PubMed PMC3329815
      13. Mukhtar NA, Ayala C, Maher JJ, Khalili M. Assessment of factors associated with pre-diabetes in HCV infection including direct and dynamic measurements of insulin action. J Viral Hepat. 2012 Jul; 19(7):480-7.
        View in: PubMed PMC3375865
      14. Schwabe RF, Maher JJ. Lipids in liver disease: looking beyond steatosis. Gastroenterology. 2012 Jan; 142(1):8-11.
        View in: PubMed PMC4097005
      15. Maher JJ. New insights from rodent models of fatty liver disease. Antioxid Redox Signal. 2011 Jul 15; 15(2):535-50.
        View in: PubMed PMC3118700
      16. Soon RK, Yan JS, Grenert JP, Maher JJ. Stress signaling in the methionine-choline-deficient model of murine fatty liver disease. Gastroenterology. 2010 Nov; 139(5):1730-9, 1739.e1.
        View in: PubMed PMC2967598
      17. Lam KD, Bacchetti P, Abbasi F, Ayala CE, Loeb SM, Shah V, Wen MJ, Reaven GM, Maher JJ, Khalili M. Comparison of surrogate and direct measurement of insulin resistance in chronic hepatitis C virus infection: impact of obesity and ethnicity. Hepatology. 2010 Jul; 52(1):38-46.
        View in: PubMed
      18. Sheikh-Bahaei S, Maher JJ, Anthony Hunt C. Computational experiments reveal plausible mechanisms for changing patterns of hepatic zonation of xenobiotic clearance and hepatotoxicity. J Theor Biol. 2010 Aug 21; 265(4):718-33.
        View in: PubMed PMC4126406
      19. Pickens MK, Ogata H, Soon RK, Grenert JP, Maher JJ. Dietary fructose exacerbates hepatocellular injury when incorporated into a methionine-choline-deficient diet. Liver Int. 2010 Sep; 30(8):1229-39.
        View in: PubMed PMC3592570
      20. Maher JJ. Trunk fat as a determinant of liver disease. Gastroenterology. 2010 Apr; 138(4):1244-6.
        View in: PubMed PMC4106472
      21. Niemann CU, Xu F, Choi S, Behrends M, Park Y, Hirose R, Maher JJ. Short passive cooling protects rats during hepatectomy by inducing heat shock proteins and limiting the induction of pro-inflammatory cytokines. J Surg Res. 2010 Jan; 158(1):43-52.
        View in: PubMed
      22. Pickens MK, Yan JS, Ng RK, Ogata H, Grenert JP, Beysen C, Turner SM, Maher JJ. Dietary sucrose is essential to the development of liver injury in the methionine-choline-deficient model of steatohepatitis. J Lipid Res. 2009 Oct; 50(10):2072-82.
        View in: PubMed PMC2739762
      23. Maher JJ. DAMPs ramp up drug toxicity. J Clin Invest. 2009 Feb; 119(2):246-9.
        View in: PubMed PMC2631305
      24. Maher JJ, Leon P, Ryan JC. Beyond insulin resistance: Innate immunity in nonalcoholic steatohepatitis. Hepatology. 2008 Aug; 48(2):670-8.
        View in: PubMed PMC3592568
      25. Liao M, Pabarcus MK, Wang Y, Hefner C, Maltby DA, Medzihradszky KF, Salas-Castillo SP, Yan J, Maher JJ, Correia MA. Impaired dexamethasone-mediated induction of tryptophan 2,3-dioxygenase in heme-deficient rat hepatocytes: translational control by a hepatic eIF2alpha kinase, the heme-regulated inhibitor. J Pharmacol Exp Ther. 2007 Dec; 323(3):979-89.
        View in: PubMed
      26. Faouzi S, Medzihradszky KF, Hefner C, Maher JJ, Correia MA. Characterization of the physiological turnover of native and inactivated cytochromes P450 3A in cultured rat hepatocytes: a role for the cytosolic AAA ATPase p97? Biochemistry. 2007 Jul 3; 46(26):7793-803.
        View in: PubMed PMC2536616
      27. Lee GS, Yan JS, Ng RK, Kakar S, Maher JJ. Polyunsaturated fat in the methionine-choline-deficient diet influences hepatic inflammation but not hepatocellular injury. J Lipid Res. 2007 Aug; 48(8):1885-96.
        View in: PubMed
      28. Maher JJ. Alcoholic steatohepatitis: management and prognosis. Curr Gastroenterol Rep. 2007 Mar; 9(1):39-46.
        View in: PubMed
      29. Niemann CU, Choi S, Behrends M, Hirose R, Noh J, Coatney JL, Roberts JP, Serkova NJ, Maher JJ. Mild hypothermia protects obese rats from fulminant hepatic necrosis induced by ischemia-reperfusion. Surgery. 2006 Sep; 140(3):404-12.
        View in: PubMed
      30. Rizki G, Arnaboldi L, Gabrielli B, Yan J, Lee GS, Ng RK, Turner SM, Badger TM, Pitas RE, Maher JJ. Mice fed a lipogenic methionine-choline-deficient diet develop hypermetabolism coincident with hepatic suppression of SCD-1. J Lipid Res. 2006 Oct; 47(10):2280-90.
        View in: PubMed
      31. Tam BY, Wei K, Rudge JS, Hoffman J, Holash J, Park SK, Yuan J, Hefner C, Chartier C, Lee JS, Jiang S, Nayak NR, Niyak NR, Kuypers FA, Ma L, Sundram U, Wu G, Garcia JA, Schrier SL, Maher JJ, Johnson RS, Yancopoulos GD, Mulligan RC, Kuo CJ. VEGF modulates erythropoiesis through regulation of adult hepatic erythropoietin synthesis. Nat Med. 2006 Jul; 12(7):793-800.
        View in: PubMed
      32. Kodali P, Wu P, Lahiji PA, Brown EJ, Maher JJ. ANIT toxicity toward mouse hepatocytes in vivo is mediated primarily by neutrophils via CD18. Am J Physiol Gastrointest Liver Physiol. 2006 Aug; 291(2):G355-63.
        View in: PubMed
      33. Hirsch J, Hansen KC, Choi S, Noh J, Hirose R, Roberts JP, Matthay MA, Burlingame AL, Maher JJ, Niemann CU. Warm ischemia-induced alterations in oxidative and inflammatory proteins in hepatic Kupffer cells in rats. Mol Cell Proteomics. 2006 Jun; 5(6):979-86.
        View in: PubMed
      34. Serkova NJ, Jackman M, Brown JL, Liu T, Hirose R, Roberts JP, Maher JJ, Niemann CU. Metabolic profiling of livers and blood from obese Zucker rats. J Hepatol. 2006 May; 44(5):956-62.
        View in: PubMed
      35. Hanson JC, Bostick MK, Campe CB, Kodali P, Lee G, Yan J, Maher JJ. Transgenic overexpression of interleukin-8 in mouse liver protects against galactosamine/endotoxin toxicity. J Hepatol. 2006 Feb; 44(2):359-67.
        View in: PubMed
      36. Han XM, Lee G, Hefner C, Maher JJ, Correia MA. Heme-reversible impairment of CYP2B1/2 induction in heme-depleted rat hepatocytes in primary culture: translational control by a hepatic alpha-subunit of the eukaryotic initiation factor kinase? J Pharmacol Exp Ther. 2005 Jul; 314(1):128-38.
        View in: PubMed
      37. Xu J, Lee G, Wang H, Vierling JM, Maher JJ. Limited role for CXC chemokines in the pathogenesis of alpha-naphthylisothiocyanate-induced liver injury. Am J Physiol Gastrointest Liver Physiol. 2004 Sep; 287(3):G734-41.
        View in: PubMed PMC3622103
      38. Maher JJ. What doesn't kill you makes you stronger: how hepatocytes survive prolonged cholestasis. Hepatology. 2004 Apr; 39(4):1141-3.
        View in: PubMed
      39. Maher JJ. Treatment of alcoholic hepatitis. J Gastroenterol Hepatol. 2002 Apr; 17(4):448-55.
        View in: PubMed
      40. Maher JJ. Alcoholic steatosis and steatohepatitis. Semin Gastrointest Dis. 2002 Jan; 13(1):31-9.
        View in: PubMed
      41. Björkegren J, Beigneux A, Bergo MO, Maher JJ, Young SG. Blocking the secretion of hepatic very low density lipoproteins renders the liver more susceptible to toxin-induced injury. J Biol Chem. 2002 Feb 15; 277(7):5476-83.
        View in: PubMed
      42. Faouzi S, Burckhardt BE, Hanson JC, Campe CB, Schrum LW, Rippe RA, Maher JJ. Anti-Fas induces hepatic chemokines and promotes inflammation by an NF-kappa B-independent, caspase-3-dependent pathway. J Biol Chem. 2001 Dec 28; 276(52):49077-82.
        View in: PubMed
      43. Maher JJ. Interactions between hepatic stellate cells and the immune system. Semin Liver Dis. 2001 Aug; 21(3):417-26.
        View in: PubMed
      44. Sonda S, Ting LM, Novak S, Kim K, Maher JJ, Farese RV, Ernst JD. Cholesterol esterification by host and parasite is essential for optimal proliferation of Toxoplasma gondii. J Biol Chem. 2001 Sep 14; 276(37):34434-40.
        View in: PubMed
      45. Wang R, Ferrell LD, Faouzi S, Maher JJ, Bishop JM. Activation of the Met receptor by cell attachment induces and sustains hepatocellular carcinomas in transgenic mice. J Cell Biol. 2001 May 28; 153(5):1023-34.
        View in: PubMed PMC2174327
      46. Maher J. Antidiabetic treatment for NASH? Hepatology. 2001 May; 33(5):1338-9.
        View in: PubMed
      47. Maher J. The CYP2E1 knockout delivers another punch: first ASH, now NASH. Alcoholic steatohepatitis. Nonalcoholic steatohepatitis. Hepatology. 2001 Jan; 33(1):311-2.
        View in: PubMed
      48. Saito JM, Maher JJ. Bile duct ligation in rats induces biliary expression of cytokine-induced neutrophil chemoattractant. Gastroenterology. 2000 Jun; 118(6):1157-68.
        View in: PubMed
      49. Maher JJ. Leukocytes as modulators of stellate cell activation. Alcohol Clin Exp Res. 1999 May; 23(5):917-21.
        View in: PubMed
      50. Maher JJ. Cytokines: overview. Semin Liver Dis. 1999; 19(2):109-15.
        View in: PubMed
      51. Maher JJ. How does estrogen enhance endotoxin toxicity? Let me count the ways. Hepatology. 1998 Dec; 28(6):1720-1.
        View in: PubMed
      52. Maher JJ, Lozier JS, Scott MK. Rat hepatic stellate cells produce cytokine-induced neutrophil chemoattractant in culture and in vivo. Am J Physiol. 1998 Oct; 275(4 Pt 1):G847-53.
        View in: PubMed
      53. Maher JJ, Neuschwander-Tetri BA. Manipulation of glutathione stores in rat hepatic stellate cells does not alter collagen synthesis. Hepatology. 1997 Sep; 26(3):618-23.
        View in: PubMed
      54. Maher JJ, Saito JM, Neuschwander-Tetri BA. Glutathione regulation in rat hepatic stellate cells. Comparative studies in primary culture and in liver injury in vivo. Biochem Pharmacol. 1997 Mar 7; 53(5):637-41.
        View in: PubMed
      55. Maher JJ, Scott MK, Saito JM, Burton MC. Adenovirus-mediated expression of cytokine-induced neutrophil chemoattractant in rat liver induces a neutrophilic hepatitis. Hepatology. 1997 Mar; 25(3):624-30.
        View in: PubMed
      56. Maher JJ. Exploring alcohol's effects on liver function. Alcohol Health Res World. 1997; 21(1):5-12.
        View in: PubMed
      57. Maher JJ. Rat hepatocytes and Kupffer cells interact to produce interleukin-8 (CINC) in the setting of ethanol. Am J Physiol. 1995 Oct; 269(4 Pt 1):G518-23.
        View in: PubMed
      58. Maher JJ, Tzagarakis C, Giménez A. Malondialdehyde stimulates collagen production by hepatic lipocytes only upon activation in primary culture. Alcohol Alcohol. 1994 Sep; 29(5):605-10.
        View in: PubMed
      59. Maher JJ, Zia S, Tzagarakis C. Acetaldehyde-induced stimulation of collagen synthesis and gene expression is dependent on conditions of cell culture: studies with rat lipocytes and fibroblasts. Alcohol Clin Exp Res. 1994 Apr; 18(2):403-9.
        View in: PubMed
      60. Maher JJ, Tzagarakis C. Partial cloning of the M subunit of laminin from adult rat lipocytes: expression of the M subunit by cells isolated from normal and injured liver. Hepatology. 1994 Mar; 19(3):764-70.
        View in: PubMed
      61. Maher JJ, Bissell DM. Cell-matrix interactions in liver. Semin Cell Biol. 1993 Jun; 4(3):189-201.
        View in: PubMed
      62. Maher JJ. Cell-specific expression of hepatocyte growth factor in liver. Upregulation in sinusoidal endothelial cells after carbon tetrachloride. J Clin Invest. 1993 May; 91(5):2244-52.
        View in: PubMed PMC288227
      63. Maher JJ, Friedman SL. Parenchymal and nonparenchymal cell interactions in the liver. Semin Liver Dis. 1993 Feb; 13(1):13-20.
        View in: PubMed
      64. Rockey DC, Maher JJ, Jarnagin WR, Gabbiani G, Friedman SL. Inhibition of rat hepatic lipocyte activation in culture by interferon-gamma. Hepatology. 1992 Sep; 16(3):776-84.
        View in: PubMed
      65. Friedman SL, Rockey DC, McGuire RF, Maher JJ, Boyles JK, Yamasaki G. Isolated hepatic lipocytes and Kupffer cells from normal human liver: morphological and functional characteristics in primary culture. Hepatology. 1992 Feb; 15(2):234-43.
        View in: PubMed
      66. Maher JJ. Yet another role for the "good" matrix protein: laminin in regenerating liver. Hepatology. 1992 Jan; 15(1):164-6.
        View in: PubMed
      67. Maher JJ, McGuire RF. Extracellular matrix gene expression increases preferentially in rat lipocytes and sinusoidal endothelial cells during hepatic fibrosis in vivo. J Clin Invest. 1990 Nov; 86(5):1641-8.
        View in: PubMed PMC296914
      68. Bissell DM, Friedman SL, Maher JJ, Roll FJ. Connective tissue biology and hepatic fibrosis: report of a conference. Hepatology. 1990 Mar; 11(3):488-98.
        View in: PubMed
      69. Maher JJ. Hepatic fibrosis caused by alcohol. Semin Liver Dis. 1990 Feb; 10(1):66-74.
        View in: PubMed
      70. Maher JJ. Fat-storing cells and myofibroblasts: one cell or two? Hepatology. 1989 Jun; 9(6):903-4.
        View in: PubMed
      71. Maher JJ. Primary hepatocyte culture: is it home away from home? Hepatology. 1988 Sep-Oct; 8(5):1162-6.
        View in: PubMed
      72. Maher JJ, Bissell DM, Friedman SL, Roll FJ. Collagen measured in primary cultures of normal rat hepatocytes derives from lipocytes within the monolayer. J Clin Invest. 1988 Aug; 82(2):450-9.
        View in: PubMed PMC303534
      73. Maher JJ, Friedman SL, Roll FJ, Bissell DM. Immunolocalization of laminin in normal rat liver and biosynthesis of laminin by hepatic lipocytes in primary culture. Gastroenterology. 1988 Apr; 94(4):1053-62.
        View in: PubMed
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