 Peder Larson, PhD
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| Title | Assistant Professor in Residence |
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| School | UCSF School of Medicine |
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| Department | Radiology and Biomedical Imaging |
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| Address | 1700 4th Street, Byers Hall
San Francisco
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| Phone | 415-514-4876 |
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 Biography | International Society for Magnetic Resonance in Medicine | 2011 | | Junior Fellow | | University of California, San Francisco | 2011 | | Surbeck Scholar Award, 1st place | | Magnetic Resonance in Medicine | 2010
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| 2012 | Distinguished Reviewer | | University of California, San Francisco | 2010 | | Surbeck Scholar Award, 1st place | | National Science Foundation Graduate Fellowship | 2003 | | Honorable Mentioned |
Overview Peder Larson, PhD, is an Assistant Professor in Residence and Principal Investigator of Larson Laboratory in the Department of Radiology and Biomedical Imaging at the University of California, San Francisco. Dr. Larson obtained his BS in Electrical Engineering and Mathematics from Stanford University in 2002, and he earned his MS in Electrical Engineering from Stanford University in 2003. Dr. Larson received his PhD in Electrical Engineering from Stanford University in 2007, followed by a postdoctoral fellowship in Radiology and Biomedical Imaging from UCSF in 2011.
Dr. Larson primarily focuses on MR pulse sequence development, including MR physics, RF pulse design, acquisition strategies, and reconstruction techniques. He is working on developing new metabolic imaging methods in preclinical studies as well as considering the challenges for clinical translation. Dr. Larson’s research program also includes the development and applications of semi-solid tissue MR imaging techniques for positive contrast of tissues such as tendons, bone, and myelin that are invisible with conventional techniques.
Dr. Larson is an active member of International Society for Magnetic Resonance in Medicine, the Institute for Electrical and Electronics Engineering, the Society of Molecular Imaging, the UC Berkeley and UCSF Graduate Group in Bioengineering, and the California Institute for Quantitative Biosciences. As of April 2013, he has published 31 articles resulting from his research.
Expertise:
Electrical Engineering, Bioengineering
Specialty:
Signal Processing, MR pulse sequence development, including MR physics, RF pulse design, acquisition strategies, and reconstruction techniques
Professional Interests:
Developing novel hyperpolarized carbon-13 metabolic MR imaging methods, which has clinical potential for applications such as cancer staging and monitoring treatment response
Development and application of semi-solid tissue MR imaging techniques for positive contrast of tissues such as tendons, bone, and myelin
Education and Training:
• Bachelor of Science: Stanford University, Palo Alto - Electrical Engineering and Mathematics
• Masters of Science: Stanford University, Palo Alto - Electrical Engineering
• Doctor of Philosophy: Stanford University, Palo Alto - Electrical Engineering
• Postdoctoral Fellowship: University of California, San Francisco - Radiology and Biomedical Imaging
Developing novel MRI methods for translation into clinical applications, including:
- hyperpolarized carbon-13 metabolic MR imaging methods, which has clinical potential for applications such as cancer staging and monitoring treatment response
- development and applications of semi-solid tissue MR imaging techniques for positive contrast of tissues such as tendons, bone, and myelin that are invisible with conventional techniques
Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications.
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Finsterbusch J, Busch MG, Larson PE. Signal scaling improves the signal-to-noise ratio of measurements with segmented 2D-selective radiofrequency excitations. Magn Reson Med. 2013 Feb 25.
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Swisher CL, Larson PE, Kruttwig K, Kerr AB, Hu S, Bok RA, Goga A, Pauly JM, Nelson SJ, Kurhanewicz J, Vigneron DB. Quantitative measurement of cancer metabolism using stimulated echo hyperpolarized carbon-13 MRS. Magn Reson Med. 2013 Feb 14.
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Koelsch BL, Keshari KR, Peeters TH, Larson PE, Wilson DM, Kurhanewicz J. Diffusion MR of hyperpolarized (13)C molecules in solution. Analyst. 2013 Jan 22; 138(4):1011-4.
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Ohliger MA, Larson PE, Bok RA, Shin P, Hu S, Tropp J, Robb F, Carvajal L, Nelson SJ, Kurhanewicz J, Vigneron DB. Combined parallel and partial fourier MR reconstruction for accelerated 8-channel hyperpolarized carbon-13 in vivo magnetic resonance spectroscopic imaging (MRSI). J Magn Reson Imaging. 2013 Jan 4.
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Larson PE, Hurd RE, Kerr AB, Pauly JM, Bok RA, Kurhanewicz J, Vigneron DB. Perfusion and diffusion sensitive (13)C stimulated-echo MRSI for metabolic imaging of cancer. Magn Reson Imaging. 2012 Dec 20.
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Hu S, Larson PE, Vancriekinge M, Leach AM, Park I, Leon C, Zhou J, Shin PJ, Reed G, Keselman P, von Morze C, Yoshihara H, Bok RA, Nelson SJ, Kurhanewicz J, Vigneron DB. Rapid sequential injections of hyperpolarized [1-(13)C]pyruvate in vivo using a sub-kelvin, multi-sample DNP polarizer. Magn Reson Imaging. 2012 Oct 26.
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Larson PE, Kerr AB, Leon Swisher C, Pauly JM, Vigneron DB. A rapid method for direct detection of metabolic conversion and magnetization exchange with application to hyperpolarized substrates. J Magn Reson. 2012 Dec; 225:71-80.
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von Morze C, Sukumar S, Reed GD, Larson PE, Bok RA, Kurhanewicz J, Vigneron DB. Frequency-specific SSFP for hyperpolarized (13)C metabolic imaging at 14.1 T. Magn Reson Imaging. 2013 Feb; 31(2):163-70.
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Reed GD, Larson PE, Morze Cv, Bok R, Lustig M, Kerr AB, Pauly JM, Kurhanewicz J, Vigneron DB. A method for simultaneous echo planar imaging of hyperpolarized ¹³C pyruvate and ¹³C lactate. J Magn Reson. 2012 Apr; 217:41-7.
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von Morze C, Larson PE, Hu S, Yoshihara HA, Bok RA, Goga A, Ardenkjaer-Larsen JH, Vigneron DB. Investigating tumor perfusion and metabolism using multiple hyperpolarized (13)C compounds: HP001, pyruvate and urea. Magn Reson Imaging. 2012 Apr; 30(3):305-11.
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Keshari KR, Kurhanewicz J, Bok R, Larson PE, Vigneron DB, Wilson DM. Hyperpolarized 13C dehydroascorbate as an endogenous redox sensor for in vivo metabolic imaging. Proc Natl Acad Sci U S A. 2011 Nov 15; 108(46):18606-11.
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Larson PE, Kerr AB, Reed GD, Hurd RE, Kurhanewicz J, Pauly JM, Vigneron DB. Generating super stimulated-echoes in MRI and their application to hyperpolarized C-13 diffusion metabolic imaging. IEEE Trans Med Imaging. 2012 Feb; 31(2):265-75.
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Hu S, Zhu M, Yoshihara HA, Wilson DM, Keshari KR, Shin P, Reed G, von Morze C, Bok R, Larson PE, Kurhanewicz J, Vigneron DB. In vivo measurement of normal rat intracellular pyruvate and lactate levels after injection of hyperpolarized [1-(13)C]alanine. Magn Reson Imaging. 2011 Oct; 29(8):1035-40.
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Krug R, Larson PE, Wang C, Burghardt AJ, Kelley DA, Link TM, Zhang X, Vigneron DB, Majumdar S. Ultrashort echo time MRI of cortical bone at 7 tesla field strength: a feasibility study. J Magn Reson Imaging. 2011 Sep; 34(3):691-5.
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Hu S, Balakrishnan A, Bok RA, Anderton B, Larson PE, Nelson SJ, Kurhanewicz J, Vigneron DB, Goga A. 13C-pyruvate imaging reveals alterations in glycolysis that precede c-Myc-induced tumor formation and regression. Cell Metab. 2011 Jul 6; 14(1):131-42.
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Larson PE, Gold GE. Science to practice: Can inflammatory arthritis be monitored by using MR imaging with injected hyperpolarized 13C-pyruvate? Radiology. 2011 May; 259(2):309-10.
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von Morze C, Reed G, Shin P, Larson PE, Hu S, Bok R, Vigneron DB. Multi-band frequency encoding method for metabolic imaging with hyperpolarized [1-(13)C]pyruvate. J Magn Reson. 2011 Aug; 211(2):109-13.
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von Morze C, Larson PE, Hu S, Keshari K, Wilson DM, Ardenkjaer-Larsen JH, Goga A, Bok R, Kurhanewicz J, Vigneron DB. Imaging of blood flow using hyperpolarized [(13)C]urea in preclinical cancer models. J Magn Reson Imaging. 2011 Mar; 33(3):692-7.
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Tropp J, Lupo JM, Chen A, Calderon P, McCune D, Grafendorfer T, Ozturk-Isik E, Larson PE, Hu S, Yen YF, Robb F, Bok R, Schulte R, Xu D, Hurd R, Vigneron D, Nelson S. Multi-channel metabolic imaging, with SENSE reconstruction, of hyperpolarized [1-(13)C] pyruvate in a live rat at 3.0 tesla on a clinical MR scanner. J Magn Reson. 2011 Jan; 208(1):171-7.
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Larson PE, Hu S, Lustig M, Kerr AB, Nelson SJ, Kurhanewicz J, Pauly JM, Vigneron DB. Fast dynamic 3D MR spectroscopic imaging with compressed sensing and multiband excitation pulses for hyperpolarized 13C studies. Magn Reson Med. 2011 Mar; 65(3):610-9.
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Dafni H, Larson PE, Hu S, Yoshihara HA, Ward CS, Venkatesh HS, Wang C, Zhang X, Vigneron DB, Ronen SM. Hyperpolarized 13C spectroscopic imaging informs on hypoxia-inducible factor-1 and myc activity downstream of platelet-derived growth factor receptor. Cancer Res. 2010 Oct 1; 70(19):7400-10.
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Wilson DM, Keshari KR, Larson PE, Chen AP, Hu S, Van Criekinge M, Bok R, Nelson SJ, Macdonald JM, Vigneron DB, Kurhanewicz J. Multi-compound polarization by DNP allows simultaneous assessment of multiple enzymatic activities in vivo. J Magn Reson. 2010 Jul; 205(1):141-7.
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Larson PE, Bok R, Kerr AB, Lustig M, Hu S, Chen AP, Nelson SJ, Pauly JM, Kurhanewicz J, Vigneron DB. Investigation of tumor hyperpolarized [1-13C]-pyruvate dynamics using time-resolved multiband RF excitation echo-planar MRSI. Magn Reson Med. 2010 Mar; 63(3):582-91.
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Hu S, Lustig M, Balakrishnan A, Larson PE, Bok R, Kurhanewicz J, Nelson SJ, Goga A, Pauly JM, Vigneron DB. 3D compressed sensing for highly accelerated hyperpolarized (13)C MRSI with in vivo applications to transgenic mouse models of cancer. Magn Reson Med. 2010 Feb; 63(2):312-21.
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Park I, Larson PE, Zierhut ML, Hu S, Bok R, Ozawa T, Kurhanewicz J, Vigneron DB, Vandenberg SR, James CD, Nelson SJ. Hyperpolarized 13C magnetic resonance metabolic imaging: application to brain tumors. Neuro Oncol. 2010 Feb; 12(2):133-44.
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Keshari KR, Wilson DM, Chen AP, Bok R, Larson PE, Hu S, Van Criekinge M, Macdonald JM, Vigneron DB, Kurhanewicz J. Hyperpolarized [2-13C]-fructose: a hemiketal DNP substrate for in vivo metabolic imaging. J Am Chem Soc. 2009 Dec 9; 131(48):17591-6.
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Larson PE, Lustig MS, Nishimura DG. Anisotropic field-of-view shapes for improved PROPELLER imaging. Magn Reson Imaging. 2009 May; 27(4):470-9.
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Larson PE, Kerr AB, Chen AP, Lustig MS, Zierhut ML, Hu S, Cunningham CH, Pauly JM, Kurhanewicz J, Vigneron DB. Multiband excitation pulses for hyperpolarized 13C dynamic chemical-shift imaging. J Magn Reson. 2008 Sep; 194(1):121-7.
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Peder E. Z. Larson, Paul T. Gurney, and Dwight G. Nishimura. IEEE Transactions on Medical Imaging. Anisotropic Field-of-views in radial imaging. 2008; 27(1):47-57.
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Larson PE, Conolly SM, Pauly JM, Nishimura DG. Using adiabatic inversion pulses for long-T2 suppression in ultrashort echo time (UTE) imaging. Magn Reson Med. 2007 Nov; 58(5):952-61.
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Larson PE, Gurney PT, Nayak K, Gold GE, Pauly JM, Nishimura DG. Designing long-T2 suppression pulses for ultrashort echo time imaging. Magn Reson Med. 2006 Jul; 56(1):94-103.
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