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    Sergio Baranzini, PhD

    SchoolUCSF School of Medicine
    Address675 Nelson Rising Lane
    San Francisco CA 94158

      Sergio E. Baranzini earned his degree in clinical biochemistry from the University of Buenos Aires, Argentina, in 1992. He graduated from the same institution in 1997 obtaining a PhD with honors in human molecular genetics. The subject of his PhD thesis was the characterization of genetic mutations leading to Duchenne’s muscular dystrophy. Dr. Baranzini then moved to the University of California at San Francisco to specialize in the analysis of complex hereditary diseases, in particular multiple sclerosis. During his postdoctoral stay in UCSF Dr. Baranzini employed state-of-the art methods to explore MS pathogenesis, including immunology, molecular biology, genomics and bioinformatics. Since 2003 Dr. Baranzini is faculty in the Department of Neurology at UCSF, where he currently holds the title of Associate Professor In-Residence. His research involves the large throughout analysis of samples from MS patients to characterize the activity of genes during: i) different stages of the disease (i.e. remission vs. relapse), ii) differential response to treatment (i.e. good responders vs. poor responders), and iii) disease progression (i.e. benign vs. severe). In addition Dr. Baranzini is collaborating with several interdisciplinary teams worldwide to integrate all the available knowledge obtained in different research domains in an approach known as systems biology. Dr Baranzini’s current research involves immunological studies using the EAE model, sequencing of whole genomes and transcriptomes from patients with multiple sclerosis and developing bioinformatics tools to integrate this information with that coming from other high throughput technologies. Dr Baranzini uses a combination of “wet lab” methods including DNA microarrays, proteomics, and laser capture microdissection, in combination with “dry lab” analytical approaches encompassing bioinformatics, complexity theory, and mathematical modeling.
      Dr. Baranzini has published his research on MS in several top-tier journals like Science, Nature, PNAS, J Immunol, and PLos Biol. He is a member of the American Association of Immunologists, and an elected member of the American Neurological Association. He also serves as an ad-hoc reviewer for many specialized journals.

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      1. Matsushita T, Madireddy L, Sprenger T, Khankhanian P, Magon S, Naegelin Y, Caverzasi E, Lindberg RL, Kappos L, Hauser SL, Oksenberg JR, Henry R, Pelletier D, Baranzini SE. Genetic associations with brain cortical thickness in multiple sclerosis. Genes Brain Behav. 2015 Feb; 14(2):217-27.
        View in: PubMed
      2. Harari D, Orr I, Rotkopf R, Baranzini SE, Schreiber G. A robust type I interferon gene signature from blood RNA defines quantitative but not qualitative differences between three major IFNß drugs in the treatment of multiple sclerosis. Hum Mol Genet. 2015 Jun 1; 24(11):3192-205.
        View in: PubMed
      3. Khankhanian P, Din L, Caillier SJ, Gourraud PA, Baranzini SE. SNP imputation bias reduces effect size determination. Front Genet. 2015; 6:30.
        View in: PubMed
        View in: PubMed
      5. Nickles D, Madireddy L, Patel N, Isobe N, Miller BL, Baranzini SE, Kramer JH, Oksenberg JR. Whole genome sequences of 2 octogenarians with sustained cognitive abilities. Neurobiol Aging. 2015 Mar; 36(3):1435-8.
        View in: PubMed
      6. Gustafsson M, Nestor CE, Zhang H, Barabási AL, Baranzini S, Brunak S, Chung KF, Federoff HJ, Gavin AC, Meehan RR, Picotti P, Pujana MÀ, Rajewsky N, Smith KG, Sterk PJ, Villoslada P, Benson M. Modules, networks and systems medicine for understanding disease and aiding diagnosis. Genome Med. 2014; 6(10):82.
        View in: PubMed
      7. Gourraud PA, Henry RG, Cree BA, Crane JC, Lizee A, Olson MP, Santaniello AV, Datta E, Zhu AH, Bevan CJ, Gelfand JM, Graves JS, Goodin DS, Green AJ, von Büdingen HC, Waubant E, Zamvil SS, Crabtree-Hartman E, Nelson S, Baranzini SE, Hauser SL. Precision medicine in chronic disease management: The multiple sclerosis BioScreen. Ann Neurol. 2014 Nov; 76(5):633-42.
        View in: PubMed PMC4214886
      8. Wang L, Matsushita T, Madireddy L, Mousavi P, Baranzini SE. PINBPA: Cytoscape app for network analysis of GWAS data. Bioinformatics. 2015 Jan 15; 31(2):262-4.
        View in: PubMed
      9. Palanichamy A, Jahn S, Nickles D, Derstine M, Abounasr A, Hauser SL, Baranzini SE, Leppert D, von Büdingen HC. Rituximab efficiently depletes increased CD20-expressing T cells in multiple sclerosis patients. J Immunol. 2014 Jul 15; 193(2):580-6.
        View in: PubMed PMC4082756
      10. Muñoz-Culla M, Irizar H, Castillo-Triviño T, Sáenz-Cuesta M, Sepúlveda L, Lopetegi I, de Munain AL, Olascoaga J, Baranzini S, Otaegui D. Blood miRNA expression pattern is a possible risk marker for natalizumab-associated progressive multifocal leukoencephalopathy in multiple sclerosis patients. Mult Scler. 2014 Dec; 20(14):1851-9.
        View in: PubMed
      11. Molofsky AV, Kelley KW, Tsai HH, Redmond SA, Chang SM, Madireddy L, Chan JR, Baranzini SE, Ullian EM, Rowitch DH. Astrocyte-encoded positional cues maintain sensorimotor circuit integrity. Nature. 2014 May 8; 509(7499):189-94.
        View in: PubMed PMC4057936
      12. Fancy SP, Harrington EP, Baranzini SE, Silbereis JC, Shiow LR, Yuen TJ, Huang EJ, Lomvardas S, Rowitch DH. Parallel states of pathological Wnt signaling in neonatal brain injury and colon cancer. Nat Neurosci. 2014 Apr; 17(4):506-12.
        View in: PubMed PMC3975168
      13. Zastepa E, Fitz-Gerald L, Hallett M, Antel J, Bar-Or A, Baranzini S, Lapierre Y, Haegert DG. Naive CD4 T-cell activation identifies MS patients having rapid transition to progressive MS. Neurology. 2014 Feb 25; 82(8):681-90.
        View in: PubMed PMC3945666
      14. Damotte V, Guillot-Noel L, Patsopoulos NA, Madireddy L, El Behi M. A gene pathway analysis highlights the role of cellular adhesion molecules in multiple sclerosis susceptibility. Genes Immun. 2014 Mar; 15(2):126-32.
        View in: PubMed
      15. Parnell GP, Gatt PN, Krupa M, Nickles D, McKay FC, Schibeci SD, Batten M, Baranzini S, Henderson A, Barnett M, Slee M, Vucic S, Stewart GJ, Booth DR. The autoimmune disease-associated transcription factors EOMES and TBX21 are dysregulated in multiple sclerosis and define a molecular subtype of disease. Clin Immunol. 2014 Mar; 151(1):16-24.
        View in: PubMed
      16. Baranzini SE. Symposium 2-1  The autoimmunome: Similarities and differences among genetic susceptibility to common immune-related diseases. Nihon Rinsho Meneki Gakkai Kaishi. 2014; 37(4):261.
        View in: PubMed
      17. Khankhanian P, Baranzini SE, Johnson BA, Madireddy L, Nickles D, Croen LA, Wu YW. Sequencing of the IL6 gene in a case-control study of cerebral palsy in children. BMC Med Genet. 2013; 14:126.
        View in: PubMed PMC3881497
      18. Baranzini SE. Gene expression profiling in MS: a fulfilled promise? Mult Scler. 2013 Dec; 19(14):1813-4.
        View in: PubMed
      19. Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. Nat Genet. 2013 Nov; 45(11):1353-60.
        View in: PubMed PMC3832895
      20. Molofsky AV, Glasgow SM, Chaboub LS, Tsai HH, Murnen AT, Kelley KW, Fancy SP, Yuen TJ, Madireddy L, Baranzini S, Deneen B, Rowitch DH, Oldham MC. Expression profiling of Aldh1l1-precursors in the developing spinal cord reveals glial lineage-specific genes and direct Sox9-Nfe2l1 interactions. Glia. 2013 Sep; 61(9):1518-32.
        View in: PubMed PMC3909648
      21. Schulze-Topphoff U, Casazza S, Varrin-Doyer M, Pekarek K, Sobel RA, Hauser SL, Oksenberg JR, Zamvil SS, Baranzini SE. Tob1 plays a critical role in the activation of encephalitogenic T cells in CNS autoimmunity. J Exp Med. 2013 Jul 1; 210(7):1301-9.
        View in: PubMed PMC3698524
      22. Rossi S, Studer V, Moscatelli A, Motta C, Coghe G, Fenu G, Caillier S, Buttari F, Mori F, Barbieri F, Castelli M, De Chiara V, Monteleone F, Mancino R, Bernardi G, Baranzini SE, Marrosu MG, Oksenberg JR, Centonze D. Opposite roles of NMDA receptors in relapsing and primary progressive multiple sclerosis. PLoS One. 2013; 8(6):e67357.
        View in: PubMed PMC3696106
      23. Nickles D, Chen HP, Li MM, Khankhanian P, Madireddy L, Caillier SJ, Santaniello A, Cree BA, Pelletier D, Hauser SL, Oksenberg JR, Baranzini SE. Blood RNA profiling in a large cohort of multiple sclerosis patients and healthy controls. Hum Mol Genet. 2013 Oct 15; 22(20):4194-205.
        View in: PubMed PMC3781642
      24. Network-based multiple sclerosis pathway analysis with GWAS data from 15,000 cases and 30,000 controls. Am J Hum Genet. 2013 Jun 6; 92(6):854-65.
        View in: PubMed PMC3958952
      25. Dutta R, Chomyk AM, Chang A, Ribaudo MV, Deckard SA, Doud MK, Edberg DD, Bai B, Li M, Baranzini SE, Fox RJ, Staugaitis SM, Macklin WB, Trapp BD. Hippocampal demyelination and memory dysfunction are associated with increased levels of the neuronal microRNA miR-124 and reduced AMPA receptors. Ann Neurol. 2013 May; 73(5):637-45.
        View in: PubMed PMC3679350
      26. Gourraud PA, Sdika M, Khankhanian P, Henry RG, Beheshtian A, Matthews PM, Hauser SL, Oksenberg JR, Pelletier D, Baranzini SE. A genome-wide association study of brain lesion distribution in multiple sclerosis. Brain. 2013 Apr; 136(Pt 4):1012-24.
        View in: PubMed PMC3613709
      27. Pappas DJ, Gabatto PA, Oksenberg D, Khankhanian P, Baranzini SE, Gan L, Oksenberg JR. Transcriptional expression patterns triggered by chemically distinct neuroprotective molecules. Neuroscience. 2012 Dec 13; 226:10-20.
        View in: PubMed PMC3489981
      28. Nickles D, Madireddy L, Yang S, Khankhanian P, Lincoln S, Hauser SL, Oksenberg JR, Baranzini SE. In depth comparison of an individual's DNA and its lymphoblastoid cell line using whole genome sequencing. BMC Genomics. 2012; 13:477.
        View in: PubMed PMC3473256
      29. Gourraud PA, Harbo HF, Hauser SL, Baranzini SE. The genetics of multiple sclerosis: an up-to-date review. Immunol Rev. 2012 Jul; 248(1):87-103.
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      30. Han MH, Lundgren DH, Jaiswal S, Chao M, Graham KL, Garris CS, Axtell RC, Ho PP, Lock CB, Woodard JI, Brownell SE, Zoudilova M, Hunt JF, Baranzini SE, Butcher EC, Raine CS, Sobel RA, Han DK, Weissman I, Steinman L. Janus-like opposing roles of CD47 in autoimmune brain inflammation in humans and mice. J Exp Med. 2012 Jul 2; 209(7):1325-34.
        View in: PubMed PMC3405500
      31. Su SY, Kasberger J, Baranzini S, Byerley W, Liao W, Oksenberg J, Sherr E, Jorgenson E. Detection of identity by descent using next-generation whole genome sequencing data. BMC Bioinformatics. 2012; 13:121.
        View in: PubMed PMC3403908
      32. Baranzini SE, Nickles D. Genetics of multiple sclerosis: swimming in an ocean of data. Curr Opin Neurol. 2012 Jun; 25(3):239-45.
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      33. Villoslada P, Baranzini S. Data integration and systems biology approaches for biomarker discovery: challenges and opportunities for multiple sclerosis. J Neuroimmunol. 2012 Jul 15; 248(1-2):58-65.
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      34. Wang L, Khankhanian P, Baranzini SE, Mousavi P. iCTNet: a Cytoscape plugin to produce and analyze integrative complex traits networks. BMC Bioinformatics. 2011; 12:380.
        View in: PubMed PMC3190406
      35. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature. 2011 Aug 11; 476(7359):214-9.
        View in: PubMed PMC3182531
      36. Fancy SP, Harrington EP, Yuen TJ, Silbereis JC, Zhao C, Baranzini SE, Bruce CC, Otero JJ, Huang EJ, Nusse R, Franklin RJ, Rowitch DH. Axin2 as regulatory and therapeutic target in newborn brain injury and remyelination. Nat Neurosci. 2011 Aug; 14(8):1009-16.
        View in: PubMed PMC3145042
      37. Slavotinek AM, Baranzini SE, Schanze D, Labelle-Dumais C, Short KM, Chao R, Yahyavi M, Bijlsma EK, Chu C, Musone S, Wheatley A, Kwok PY, Marles S, Fryns JP, Maga AM, Hassan MG, Gould DB, Madireddy L, Li C, Cox TC, Smyth I, Chudley AE, Zenker M. Manitoba-oculo-tricho-anal (MOTA) syndrome is caused by mutations in FREM1. J Med Genet. 2011 Jun; 48(6):375-82.
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      38. Haghikia A, Perrech M, Pula B, Ruhrmann S, Potthoff A, Brockmeyer NH, Goelz S, Wiendl H, Lindå H, Ziemssen T, Baranzini SE, Käll TB, Bengel D, Olsson T, Gold R, Chan A. Functional energetics of CD4+-cellular immunity in monoclonal antibody-associated progressive multifocal leukoencephalopathy in autoimmune disorders. PLoS One. 2011; 6(4):e18506.
        View in: PubMed PMC3080364
      39. Wang JH, Pappas D, De Jager PL, Pelletier D, de Bakker PI, Kappos L, Polman CH. Modeling the cumulative genetic risk for multiple sclerosis from genome-wide association data. Genome Med. 2011; 3(1):3.
        View in: PubMed PMC3092088
      40. Baranzini SE. Revealing the genetic basis of multiple sclerosis: are we there yet? Curr Opin Genet Dev. 2011 Jun; 21(3):317-24.
        View in: PubMed PMC3105160
      41. Fancy SP, Chan JR, Baranzini SE, Franklin RJ, Rowitch DH. Myelin regeneration: a recapitulation of development? Annu Rev Neurosci. 2011; 34:21-43.
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      42. Sorani MD, Manley GT, Claude Hemphill J, Baranzini SE. Dynamic, multi-level network models of clinical trials. Pac Symp Biocomput. 2011; 38-49.
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      43. Khankhanian P, Gourraud PA, Caillier SJ, Santaniello A, Hauser SL, Baranzini SE, Oksenberg JR. Genetic variation in the odorant receptors family 13 and the mhc loci influence mate selection in a multiple sclerosis dataset. BMC Genomics. 2010; 11:626.
        View in: PubMed PMC3091764
      44. Baranzini SE, Srinivasan R, Khankhanian P, Okuda DT, Nelson SJ, Matthews PM, Hauser SL, Oksenberg JR, Pelletier D. Genetic variation influences glutamate concentrations in brains of patients with multiple sclerosis. Brain. 2010 Sep; 133(9):2603-11.
        View in: PubMed PMC2929334
      45. Oksenberg JR, Baranzini SE. Multiple sclerosis genetics--is the glass half full, or half empty? Nat Rev Neurol. 2010 Aug; 6(8):429-37.
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      46. Baranzini SE, Mudge J, van Velkinburgh JC, Khankhanian P, Khrebtukova I, Miller NA, Zhang L, Farmer AD, Bell CJ, Kim RW, May GD, Woodward JE, Caillier SJ, McElroy JP, Gomez R, Pando MJ, Clendenen LE, Ganusova EE, Schilkey FD, Ramaraj T, Khan OA, Huntley JJ, Luo S, Kwok PY, Wu TD, Schroth GP, Oksenberg JR, Hauser SL, Kingsmore SF. Genome, epigenome and RNA sequences of monozygotic twins discordant for multiple sclerosis. Nature. 2010 Apr 29; 464(7293):1351-6.
        View in: PubMed PMC2862593
      47. Baranzini SE. The genetics of autoimmune diseases: a networked perspective. Curr Opin Immunol. 2009 Dec; 21(6):596-605.
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      48. Otaegui D, Baranzini SE, Armañanzas R, Calvo B, Muñoz-Culla M, Khankhanian P, Inza I, Lozano JA, Castillo-Triviño T, Asensio A, Olaskoaga J, López de Munain A. Differential micro RNA expression in PBMC from multiple sclerosis patients. PLoS One. 2009; 4(7):e6309.
        View in: PubMed PMC2708922
      49. Pappas DJ, Coppola G, Gabatto PA, Gao F, Geschwind DH, Oksenberg JR, Baranzini SE. Longitudinal system-based analysis of transcriptional responses to type I interferons. Physiol Genomics. 2009 Aug 7; 38(3):362-71.
        View in: PubMed
      50. De Jager PL, Jia X, Wang J, de Bakker PI, Ottoboni L, Aggarwal NT, Piccio L, Raychaudhuri S, Tran D, Aubin C, Briskin R, Romano S. Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. Nat Genet. 2009 Jul; 41(7):776-82.
        View in: PubMed PMC2757648
      51. Fancy SP, Baranzini SE, Zhao C, Yuk DI, Irvine KA, Kaing S, Sanai N, Franklin RJ, Rowitch DH. Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS. Genes Dev. 2009 Jul 1; 23(13):1571-85.
        View in: PubMed PMC2704469
      52. Baranzini SE, Galwey NW, Wang J, Khankhanian P, Lindberg R, Pelletier D, Wu W, Uitdehaag BM, Kappos L. Pathway and network-based analysis of genome-wide association studies in multiple sclerosis. Hum Mol Genet. 2009 Jun 1; 18(11):2078-90.
        View in: PubMed PMC2678928
      53. Villoslada P, Steinman L, Baranzini SE. Systems biology and its application to the understanding of neurological diseases. Ann Neurol. 2009 Feb; 65(2):124-39.
        View in: PubMed
      54. Okuda DT, Mowry EM, Beheshtian A, Waubant E, Baranzini SE, Goodin DS, Hauser SL, Pelletier D. Incidental MRI anomalies suggestive of multiple sclerosis: the radiologically isolated syndrome. Neurology. 2009 Mar 3; 72(9):800-5.
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      55. Okuda DT, Srinivasan R, Oksenberg JR, Goodin DS, Baranzini SE, Beheshtian A, Waubant E, Zamvil SS, Leppert D, Qualley P, Lincoln R, Gomez R, Caillier S, George M, Wang J, Nelson SJ, Cree BA, Hauser SL, Pelletier D. Genotype-Phenotype correlations in multiple sclerosis: HLA genes influence disease severity inferred by 1HMR spectroscopy and MRI measures. Brain. 2009 Jan; 132(Pt 1):250-9.
        View in: PubMed PMC2638695
      56. Baranzini SE, Wang J, Gibson RA, Galwey N, Naegelin Y, Barkhof F, Radue EW, Lindberg RL, Uitdehaag BM, Johnson MR, Angelakopoulou A, Hall L, Richardson JC, Prinjha RK, Gass A, Geurts JJ, Kragt J, Sombekke M, Vrenken H, Qualley P, Lincoln RR, Gomez R, Caillier SJ, George MF, Mousavi H, Guerrero R, Okuda DT, Cree BA, Green AJ, Waubant E, Goodin DS, Pelletier D, Matthews PM, Hauser SL, Kappos L, Polman CH, Oksenberg JR. Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis. Hum Mol Genet. 2009 Feb 15; 18(4):767-78.
        View in: PubMed
      57. Comabella M, Río J, Espejo C, Ruiz de Villa M, Al-Zayat H, Nos C, Deisenhammer F, Baranzini SE, Nonell L, López C, Julià E, Oksenberg JR, Montalban X. Changes in matrix metalloproteinases and their inhibitors during interferon-beta treatment in multiple sclerosis. Clin Immunol. 2009 Feb; 130(2):145-50.
        View in: PubMed
      58. Caillier SJ, Briggs F, Cree BA, Baranzini SE, Fernandez-Viña M, Ramsay PP, Khan O, Royal W, Hauser SL, Barcellos LF, Oksenberg JR. Uncoupling the roles of HLA-DRB1 and HLA-DRB5 genes in multiple sclerosis. J Immunol. 2008 Oct 15; 181(8):5473-80.
        View in: PubMed
      59. Corvol JC, Pelletier D, Henry RG, Caillier SJ, Wang J, Pappas D, Casazza S, Okuda DT, Hauser SL, Oksenberg JR, Baranzini SE. Abrogation of T cell quiescence characterizes patients at high risk for multiple sclerosis after the initial neurological event. Proc Natl Acad Sci U S A. 2008 Aug 19; 105(33):11839-44.
        View in: PubMed PMC2504481
      60. Oksenberg JR, Baranzini SE, Sawcer S, Hauser SL. The genetics of multiple sclerosis: SNPs to pathways to pathogenesis. Nat Rev Genet. 2008 Jul; 9(7):516-26.
        View in: PubMed
      61. Hunt CA, Baranzini S, Matthay MA, Park S. A framework and mechanistically focused, in silico method for enabling rational translational research. Summit on Translat Bioinforma. 2008; 2008:46-50.
        View in: PubMed PMC3041517
      62. Han MH, Hwang SI, Roy DB, Lundgren DH, Price JV, Ousman SS, Fernald GH, Gerlitz B, Robinson WH, Baranzini SE, Grinnell BW, Raine CS, Sobel RA, Han DK, Steinman L. Proteomic analysis of active multiple sclerosis lesions reveals therapeutic targets. Nature. 2008 Feb 28; 451(7182):1076-81.
        View in: PubMed
      63. Goertsches R, Baranzini SE, Morcillo C, Nos C, Camiña M, Oksenberg JR, Montalban X, Comabella M. Evidence for association of chromosome 10 open reading frame (C10orf27) gene polymorphisms and multiple sclerosis. Mult Scler. 2008 Apr; 14(3):412-4.
        View in: PubMed
      64. Byun E, Caillier SJ, Montalban X, Villoslada P, Fernández O, Brassat D, Comabella M, Wang J, Barcellos LF, Baranzini SE, Oksenberg JR. Genome-wide pharmacogenomic analysis of the response to interferon beta therapy in multiple sclerosis. Arch Neurol. 2008 Mar; 65(3):337-44.
        View in: PubMed
      65. Otaegui D, Mostafavi S, Bernard CC, Lopez de Munain A, Mousavi P, Oksenberg JR, Baranzini SE. Increased transcriptional activity of milk-related genes following the active phase of experimental autoimmune encephalomyelitis and multiple sclerosis. J Immunol. 2007 Sep 15; 179(6):4074-82.
        View in: PubMed
      66. Sriram U, Wong M, Caillier SJ, Hecht FM, Elkins MK, Levy JA, Oksenberg JR, Baranzini SE. Quantitative longitudinal analysis of T cell receptor repertoire expression in HIV-infected patients on antiretroviral and interleukin-2 therapy. AIDS Res Hum Retroviruses. 2007 May; 23(5):741-7.
        View in: PubMed
      67. Fernald GH, Knott S, Pachner A, Caillier SJ, Narayan K, Oksenberg JR, Mousavi P, Baranzini SE. Genome-wide network analysis reveals the global properties of IFN-beta immediate transcriptional effects in humans. J Immunol. 2007 Apr 15; 178(8):5076-85.
        View in: PubMed
      68. Pedemonte E, Benvenuto F, Casazza S, Mancardi G, Oksenberg JR, Uccelli A, Baranzini SE. The molecular signature of therapeutic mesenchymal stem cells exposes the architecture of the hematopoietic stem cell niche synapse. BMC Genomics. 2007; 8:65.
        View in: PubMed PMC1821333
      69. Dunn SE, Ousman SS, Sobel RA, Zuniga L, Baranzini SE, Youssef S, Crowell A, Loh J, Oksenberg J, Steinman L. Peroxisome proliferator-activated receptor (PPAR)alpha expression in T cells mediates gender differences in development of T cell-mediated autoimmunity. J Exp Med. 2007 Feb 19; 204(2):321-30.
        View in: PubMed PMC2118721
      70. Baranzini SE. Systems-based medicine approaches to understand and treat complex diseases. The example of multiple sclerosis. Autoimmunity. 2006 Dec; 39(8):651-62.
        View in: PubMed
      71. Barcellos LF, Sawcer S, Ramsay PP, Baranzini SE, Thomson G, Briggs F, Cree BC, Begovich AB, Villoslada P, Montalban X, Uccelli A, Savettieri G, Lincoln RR, DeLoa C, Haines JL, Pericak-Vance MA, Compston A, Hauser SL, Oksenberg JR. Heterogeneity at the HLA-DRB1 locus and risk for multiple sclerosis. Hum Mol Genet. 2006 Sep 15; 15(18):2813-24.
        View in: PubMed
      72. Mostafavi S, Baranzini S, Oksernberg J, Mousavi P. Predictive modeling of therapy response in multiple sclerosis using gene expression data. Conf Proc IEEE Eng Med Biol Soc. 2006; 1:5519-22.
        View in: PubMed
      73. Fernald GH, Yeh RF, Hauser SL, Oksenberg JR, Baranzini SE. Mapping gene activity in complex disorders: Integration of expression and genomic scans for multiple sclerosis. J Neuroimmunol. 2005 Oct; 167(1-2):157-69.
        View in: PubMed
      74. Baranzini SE, Bernard CC, Oksenberg JR. Modular transcriptional activity characterizes the initiation and progression of autoimmune encephalomyelitis. J Immunol. 2005 Jun 1; 174(11):7412-22.
        View in: PubMed
      75. Baranzini SE, Oksenberg JR. Genomics and new targets for multiple sclerosis. Pharmacogenomics. 2005 Mar; 6(2):151-61.
        View in: PubMed
      76. Elkins MK, Vittinghoff E, Baranzini SE, Hecht FM, Sriram U, Busch MP, Levy JA, Oksenberg JR. Longitudinal analysis of B cell repertoire and antibody gene rearrangements during early HIV infection. Genes Immun. 2005 Feb; 6(1):66-9.
        View in: PubMed
      77. Baranzini SE, Mousavi P, Rio J, Caillier SJ, Stillman A, Villoslada P, Wyatt MM, Comabella M, Greller LD, Somogyi R, Montalban X, Oksenberg JR. Transcription-based prediction of response to IFNbeta using supervised computational methods. PLoS Biol. 2005 Jan; 3(1):e2.
        View in: PubMed PMC539058
      78. Baranzini SE. Gene expression profiling in neurological disorders: toward a systems-level understanding of the brain. Neuromolecular Med. 2004; 6(1):31-51.
        View in: PubMed
      79. Oksenberg JR, Barcellos LF, Cree BA, Baranzini SE, Bugawan TL, Khan O, Lincoln RR, Swerdlin A, Mignot E, Lin L, Goodin D, Erlich HA, Schmidt S, Thomson G, Reich DE, Pericak-Vance MA, Haines JL, Hauser SL. Mapping multiple sclerosis susceptibility to the HLA-DR locus in African Americans. Am J Hum Genet. 2004 Jan; 74(1):160-7.
        View in: PubMed PMC1181903
      80. Huuskonen J, Abedin M, Vishnu M, Pullinger CR, Baranzini SE, Kane JP, Fielding PE, Fielding CJ. Dynamic regulation of alternative ATP-binding cassette transporter A1 transcripts. Biochem Biophys Res Commun. 2003 Jun 27; 306(2):463-8.
        View in: PubMed
      81. Caillier S, Barcellos LF, Baranzini SE, Swerdlin A, Lincoln RR, Steinman L, Martin E, Haines JL, Pericak-Vance M, Hauser SL, Oksenberg JR. Osteopontin polymorphisms and disease course in multiple sclerosis. Genes Immun. 2003 Jun; 4(4):312-5.
        View in: PubMed
      82. Giliberto F, Ferreiro V, Dalamón V, Surace E, Cotignola J, Esperante S, Borelina D, Baranzini S, Szijan I. Direct deletion analysis in two Duchenne muscular dystrophy symptomatic females using polymorphic dinucleotide (CA)n loci within the dystrophin gene. J Biochem Mol Biol. 2003 Mar 31; 36(2):179-84.
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      83. Sriram U, Barcellos LF, Villoslada P, Rio J, Baranzini SE, Caillier S, Stillman A, Hauser SL, Montalban X, Oksenberg JR. Pharmacogenomic analysis of interferon receptor polymorphisms in multiple sclerosis. Genes Immun. 2003 Mar; 4(2):147-52.
        View in: PubMed
      84. Baranzini SE, Hauser SL. Large-scale gene-expression studies and the challenge of multiple sclerosis. Genome Biol. 2002 Sep 16; 3(10):reviews1027.
        View in: PubMed PMC244911
      85. Villoslada P, Barcellos LF, Rio J, Begovich AB, Tintore M, Sastre-Garriga J, Baranzini SE, Casquero P, Hauser SL, Montalban X, Oksenberg JR. The HLA locus and multiple sclerosis in Spain. Role in disease susceptibility, clinical course and response to interferon-beta. J Neuroimmunol. 2002 Sep; 130(1-2):194-201.
        View in: PubMed
      86. Baranzini SE, Laxer K, Bollen A, Oksenberg JR. Gene expression analysis reveals altered brain transcription of glutamate receptors and inflammatory genes in a patient with chronic focal (Rasmussen's) encephalitis. J Neuroimmunol. 2002 Jul; 128(1-2):9-15.
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      87. Baranzini SE, Laxer K, Saketkhoo R, Elkins MK, Parent JM, Mantegazza R, Oksenberg JR. Analysis of antibody gene rearrangement, usage, and specificity in chronic focal encephalitis. Neurology. 2002 Mar 12; 58(5):709-16.
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      88. Baranzini SE, Oksenberg JR, Hauser SL. New insights into the genetics of multiple sclerosis. J Rehabil Res Dev. 2002 Mar-Apr; 39(2):201-9.
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      89. Chabas D, Baranzini SE, Mitchell D, Bernard CC, Rittling SR, Denhardt DT, Sobel RA, Lock C, Karpuj M, Pedotti R, Heller R, Oksenberg JR, Steinman L. The influence of the proinflammatory cytokine, osteopontin, on autoimmune demyelinating disease. Science. 2001 Nov 23; 294(5547):1731-5.
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      90. Oksenberg JR, Baranzini SE, Barcellos LF, Hauser SL. Multiple sclerosis: genomic rewards. J Neuroimmunol. 2001 Feb 15; 113(2):171-84.
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      91. Baranzini SE, Elfstrom C, Chang SY, Butunoi C, Murray R, Higuchi R, Oksenberg JR. Transcriptional analysis of multiple sclerosis brain lesions reveals a complex pattern of cytokine expression. J Immunol. 2000 Dec 1; 165(11):6576-82.
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      92. Baranzini SE, Jeong MC, Butunoi C, Murray RS, Bernard CC, Oksenberg JR. B cell repertoire diversity and clonal expansion in multiple sclerosis brain lesions. J Immunol. 1999 Nov 1; 163(9):5133-44.
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      93. Baranzini SE, Giliberto F, Dalamon V, Barreiro C, García-Erro M, Grippo J, Szijan I. Carrier detection in Duchenne and Becker muscular dystrophy Argentine families. Clin Genet. 1998 Dec; 54(6):503-11.
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      94. Baranzini SE, Giliberto F, Herrera M, Bernath V, Barreiro C, Garcia Erro M, Grippo J, Szijan I. Deletion patterns in Argentine patients with Duchenne and Becker muscular dystrophy. Neurol Res. 1998 Jul; 20(5):409-414.
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      95. Arbetman A, Abdala M, Fandiño A, Herrera J, Baranzini S, Borelina D, Parma D, Manzitti J, Barreiro C, Giliberto F, Szijan I. Clinical, cytogenetic, and molecular testing of Argentine patients with retinoblastoma. J AAPOS. 1998 Apr; 2(2):102-7.
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      96. Baranzini SE, Lenk U, Szijan I, Speer A. Four new polymorphisms in the human dystrophin gene from an Argentinian population. Muscle Nerve. 1997 Nov; 20(11):1451-3.
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      97. Baranzini SE, del Rey G, Nigro N, Szijan I, Chamoles N, Cresto JC. Patient with an Xp21 contiguous gene deletion syndrome in association with agenesis of the corpus callosum. Am J Med Genet. 1997 Jun 13; 70(3):216-21.
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      98. di Fulvio M, Chiesa AE, Baranzini SE, Gruñiero-Papendieck L, Masini-Repiso AM, Targovnik HM. A new point mutation (M313T) in the thyroid hormone receptor beta gene in a patient with resistance to thyroid hormone. Thyroid. 1997 Feb; 7(1):43-4.
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