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    Allan Basbaum, PhD

    TitleProfessor
    SchoolUCSF School of Medicine
    DepartmentAnatomy
    Address1550 4th Street, Bldg 19B
    San Francisco CA 94158
    Phone415-476-5270
      Other Positions
      TitleChair, Anatomy


       Overview 
       Overview
      My research is interested in the mechanisms through which tissue or nerve injury result in persistent/chronic pain. A major question is the extent to which different features of the pain experience are evoked by the activity of selected subsets of "pain fibers" (i.e. nociceptors) vs. by differential patterns of activity generated across multiple populations of afferents. To understand the functional significance of the molecular complexity of the nociceptor, my group studies pain behavior in mice with deletions of different genes that code for tranducers of injury stimuli or that code for different neurotransmitter receptors and second messenger molecules. Among the many molecules that we have studied are the TRP channels (including TRPV1 and TRPM8) as well as major second messenger molecules, notably the gamma isoform of protcin kinase C, which we have implicated in the development of nerve injury-induced neuropathic pain. More recently, we have initiated a parallel series of studies that is examining the circuits that underlie the production of itch. Our focus is on the differential contribution of subsets of nociceptors to scratching behavior evoked by distinct pruritogens, including histamine, endothelin-1 and serotonin.


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       Bibliographic 
       Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Braz JM, Juarez-Salinas D, Ross SE, Basbaum AI. Transplant restoration of spinal cord inhibitory controls ameliorates neuropathic itch. J Clin Invest. 2014 Aug 1; 124(8):3612-6.
        View in: PubMed
      2. Braz J, Solorzano C, Wang X, Basbaum AI. Transmitting pain and itch messages: a contemporary view of the spinal cord circuits that generate gate control. Neuron. 2014 May 7; 82(3):522-36.
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      3. Southwell DG, Nicholas CR, Basbaum AI, Stryker MP, Kriegstein AR, Rubenstein JL, Alvarez-Buylla A. Interneurons from embryonic development to cell-based therapy. Science. 2014 Apr 11; 344(6180):1240622.
        View in: PubMed
      4. Bardoni R, Tawfik VL, Wang D, François A, Solorzano C, Shuster SA, Choudhury P, Betelli C, Cassidy C, Smith K, de Nooij JC, Mennicken F, O'Donnell D, Kieffer BL, Woodbury CJ, Basbaum AI, Macdermott AB, Scherrer G. Delta opioid receptors presynaptically regulate cutaneous mechanosensory neuron input to the spinal cord dorsal horn. Neuron. 2014 Mar 19; 81(6):1312-27.
        View in: PubMed
      5. Cevikbas F, Wang X, Akiyama T, Kempkes C, Savinko T, Antal A, Kukova G, Buhl T, Ikoma A, Buddenkotte J, Soumelis V, Feld M, Alenius H, Dillon SR, Carstens E, Homey B, Basbaum A, Steinhoff M. A sensory neuron-expressed IL-31 receptor mediates T helper cell-dependent itch: Involvement of TRPV1 and TRPA1. J Allergy Clin Immunol. 2014 Feb; 133(2):448-460.e7.
        View in: PubMed
      6. Mandadi S, Hong P, Tran MA, Bráz JM, Colarusso P, Basbaum AI, Whelan PJ. Identification of multisegmental nociceptive afferents that modulate locomotor circuits in the neonatal mouse spinal cord. J Comp Neurol. 2013 Aug 15; 521(12):2870-87.
        View in: PubMed
      7. Huang F, Wang X, Ostertag EM, Nuwal T, Huang B, Jan YN, Basbaum AI, Jan LY. TMEM16C facilitates Na(+)-activated K+ currents in rat sensory neurons and regulates pain processing. Nat Neurosci. 2013 Sep; 16(9):1284-90.
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      8. Wang X, Zhang J, Eberhart D, Urban R, Meda K, Solorzano C, Yamanaka H, Rice D, Basbaum AI. Excitatory superficial dorsal horn interneurons are functionally heterogeneous and required for the full behavioral expression of pain and itch. Neuron. 2013 Apr 24; 78(2):312-24.
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      9. Gibbs JL, Urban R, Basbaum AI. Paradoxical surrogate markers of dental injury-induced pain in the mouse. Pain. 2013 Aug; 154(8):1358-67.
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      10. Zhang J, Cavanaugh DJ, Nemenov MI, Basbaum AI. The modality-specific contribution of peptidergic and non-peptidergic nociceptors is manifest at the level of dorsal horn nociresponsive neurons. J Physiol. 2013 Feb 15; 591(Pt 4):1097-110.
        View in: PubMed
      11. Wang X, Babayan AH, Basbaum AI, Phelps PE. Loss of the Reelin-signaling pathway differentially disrupts heat, mechanical and chemical nociceptive processing. Neuroscience. 2012 Dec 13; 226:441-50.
        View in: PubMed
      12. Bráz JM, Sharif-Naeini R, Vogt D, Kriegstein A, Alvarez-Buylla A, Rubenstein JL, Basbaum AI. Forebrain GABAergic neuron precursors integrate into adult spinal cord and reduce injury-induced neuropathic pain. Neuron. 2012 May 24; 74(4):663-75.
        View in: PubMed
      13. Bohlen CJ, Chesler AT, Sharif-Naeini R, Medzihradszky KF, Zhou S, King D, Sánchez EE, Burlingame AL, Basbaum AI, Julius D. A heteromeric Texas coral snake toxin targets acid-sensing ion channels to produce pain. Nature. 2011 Nov 17; 479(7373):410-4.
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      14. Bráz JM, Ackerman L, Basbaum AI. Sciatic nerve transection triggers release and intercellular transfer of a genetically expressed macromolecular tracer in dorsal root ganglia. J Comp Neurol. 2011 Sep 1; 519(13):2648-57.
        View in: PubMed
      15. Cavanaugh DJ, Chesler AT, Bráz JM, Shah NM, Julius D, Basbaum AI. Restriction of transient receptor potential vanilloid-1 to the peptidergic subset of primary afferent neurons follows its developmental downregulation in nonpeptidergic neurons. J Neurosci. 2011 Jul 13; 31(28):10119-27.
        View in: PubMed
      16. Cavanaugh DJ, Chesler AT, Jackson AC, Sigal YM, Yamanaka H, Grant R, O'Donnell D, Nicoll RA, Shah NM, Julius D, Basbaum AI. Trpv1 reporter mice reveal highly restricted brain distribution and functional expression in arteriolar smooth muscle cells. J Neurosci. 2011 Mar 30; 31(13):5067-77.
        View in: PubMed
      17. Gibbs JL, Melnyk JL, Basbaum AI. Differential TRPV1 and TRPV2 channel expression in dental pulp. J Dent Res. 2011 Jun; 90(6):765-70.
        View in: PubMed
      18. Urban R, Scherrer G, Goulding EH, Tecott LH, Basbaum AI. Behavioral indices of ongoing pain are largely unchanged in male mice with tissue or nerve injury-induced mechanical hypersensitivity. Pain. 2011 May; 152(5):990-1000.
        View in: PubMed
      19. Sharif-Naeini R, Basbaum AI. Targeting pain where it resides ... In the brain. Sci Transl Med. 2011 Jan 12; 3(65):65ps1.
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      20. Mogil JS, Basbaum AI. Introducing the Biennial review of pain. Pain. 2011 Mar; 152(3 Suppl):S1.
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      21. Scherrer G, Low SA, Wang X, Zhang J, Yamanaka H, Urban R, Solorzano C, Harper B, Hnasko TS, Edwards RH, Basbaum AI. VGLUT2 expression in primary afferent neurons is essential for normal acute pain and injury-induced heat hypersensitivity. Proc Natl Acad Sci U S A. 2010 Dec 21; 107(51):22296-301.
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      22. Shields SD, Moore KD, Phelps PE, Basbaum AI. Olfactory ensheathing glia express aquaporin 1. J Comp Neurol. 2010 Nov 1; 518(21):4329-41.
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      23. Shields SD, Cavanaugh DJ, Lee H, Anderson DJ, Basbaum AI. Pain behavior in the formalin test persists after ablation of the great majority of C-fiber nociceptors. Pain. 2010 Nov; 151(2):422-9.
        View in: PubMed
      24. Bráz JM, Basbaum AI. Differential ATF3 expression in dorsal root ganglion neurons reveals the profile of primary afferents engaged by diverse noxious chemical stimuli. Pain. 2010 Aug; 150(2):290-301.
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      25. Faktorovich EG, Basbaum AI. Effect of topical 0.5% morphine on postoperative pain after photorefractive keratectomy. J Refract Surg. 2010 Dec; 26(12):934-41.
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      26. Bates EA, Nikai T, Brennan KC, Fu YH, Charles AC, Basbaum AI, Ptácek LJ, Ahn AH. Sumatriptan alleviates nitroglycerin-induced mechanical and thermal allodynia in mice. Cephalalgia. 2010 Feb; 30(2):170-8.
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      27. Seal RP, Wang X, Guan Y, Raja SN, Woodbury CJ, Basbaum AI, Edwards RH. Injury-induced mechanical hypersensitivity requires C-low threshold mechanoreceptors. Nature. 2009 Dec 3; 462(7273):651-5.
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      28. Basbaum AI, Bautista DM, Scherrer G, Julius D. Cellular and molecular mechanisms of pain. Cell. 2009 Oct 16; 139(2):267-84.
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      29. Bráz JM, Basbaum AI. Triggering genetically-expressed transneuronal tracers by peripheral axotomy reveals convergent and segregated sensory neuron-spinal cord connectivity. Neuroscience. 2009 Nov 10; 163(4):1220-32.
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      30. Imamachi N, Park GH, Lee H, Anderson DJ, Simon MI, Basbaum AI, Han SK. TRPV1-expressing primary afferents generate behavioral responses to pruritogens via multiple mechanisms. Proc Natl Acad Sci U S A. 2009 Jul 7; 106(27):11330-5.
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      31. Scherrer G, Imamachi N, Cao YQ, Contet C, Mennicken F, O'Donnell D, Kieffer BL, Basbaum AI. Dissociation of the opioid receptor mechanisms that control mechanical and heat pain. Cell. 2009 Jun 12; 137(6):1148-59.
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      32. Cavanaugh DJ, Lee H, Lo L, Shields SD, Zylka MJ, Basbaum AI, Anderson DJ. Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli. Proc Natl Acad Sci U S A. 2009 Jun 2; 106(22):9075-80.
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      33. Braz JM, Enquist LW, Basbaum AI. Inputs to serotonergic neurons revealed by conditional viral transneuronal tracing. J Comp Neurol. 2009 May 10; 514(2):145-60.
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      34. Wang X, Ratnam J, Zou B, England PM, Basbaum AI. TrkB signaling is required for both the induction and maintenance of tissue and nerve injury-induced persistent pain. J Neurosci. 2009 Apr 29; 29(17):5508-15.
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      35. Basbaum AI. Change is coming! Pain. 2009 Jan; 141(1-2):1.
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      36. Ossovskaya VS, Dolganov G, Basbaum AI. Loss of function genetic screens reveal MTGR1 as an intracellular repressor of beta1 integrin-dependent neurite outgrowth. J Neurosci Methods. 2009 Mar 15; 177(2):322-33.
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      37. Nikai T, Basbaum AI, Ahn AH. Profound reduction of somatic and visceral pain in mice by intrathecal administration of the anti-migraine drug, sumatriptan. Pain. 2008 Oct 31; 139(3):533-40.
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      38. Neumann S, Braz JM, Skinner K, Llewellyn-Smith IJ, Basbaum AI. Innocuous, not noxious, input activates PKCgamma interneurons of the spinal dorsal horn via myelinated afferent fibers. J Neurosci. 2008 Aug 6; 28(32):7936-44.
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      39. Braz JM, Basbaum AI. Genetically expressed transneuronal tracer reveals direct and indirect serotonergic descending control circuits. J Comp Neurol. 2008 Apr 20; 507(6):1990-2003.
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      40. Akopians AL, Babayan AH, Beffert U, Herz J, Basbaum AI, Phelps PE. Contribution of the Reelin signaling pathways to nociceptive processing. Eur J Neurosci. 2008 Feb; 27(3):523-37.
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      41. Lewinter RD, Scherrer G, Basbaum AI. Dense transient receptor potential cation channel, vanilloid family, type 2 (TRPV2) immunoreactivity defines a subset of motoneurons in the dorsal lateral nucleus of the spinal cord, the nucleus ambiguus and the trigeminal motor nucleus in rat. Neuroscience. 2008 Jan 2; 151(1):164-73.
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      42. Trevisani M, Siemens J, Materazzi S, Bautista DM, Nassini R, Campi B, Imamachi N, Andrè E, Patacchini R, Cottrell GS, Gatti R, Basbaum AI, Bunnett NW, Julius D, Geppetti P. 4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1. Proc Natl Acad Sci U S A. 2007 Aug 14; 104(33):13519-24.
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      43. Bautista DM, Siemens J, Glazer JM, Tsuruda PR, Basbaum AI, Stucky CL, Jordt SE, Julius D. The menthol receptor TRPM8 is the principal detector of environmental cold. Nature. 2007 Jul 12; 448(7150):204-8.
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      44. Shields SD, Mazario J, Skinner K, Basbaum AI. Anatomical and functional analysis of aquaporin 1, a water channel in primary afferent neurons. Pain. 2007 Sep; 131(1-2):8-20.
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      45. Mazarío J, Basbaum AI. Contribution of substance P and neurokinin A to the differential injury-induced thermal and mechanical responsiveness of lamina I and V neurons. J Neurosci. 2007 Jan 24; 27(4):762-70.
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      46. Siemens J, Zhou S, Piskorowski R, Nikai T, Lumpkin EA, Basbaum AI, King D, Julius D. Spider toxins activate the capsaicin receptor to produce inflammatory pain. Nature. 2006 Nov 9; 444(7116):208-12.
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      47. Eckert WA, Julius D, Basbaum AI. Differential contribution of TRPV1 to thermal responses and tissue injury-induced sensitization of dorsal horn neurons in laminae I and V in the mouse. Pain. 2006 Dec 15; 126(1-3):184-97.
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      48. Basbaum AI. Reviews: topical, systematic and once again, comprehensive. Pain. 2006 Oct; 124(3):237.
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      49. Ahn AH, Basbaum AI. Tissue injury regulates serotonin 1D receptor expression: implications for the control of migraine and inflammatory pain. J Neurosci. 2006 Aug 9; 26(32):8332-8.
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      50. Scherrer G, Tryoen-Tóth P, Filliol D, Matifas A, Laustriat D, Cao YQ, Basbaum AI, Dierich A, Vonesh JL, Gavériaux-Ruff C, Kieffer BL. Knockin mice expressing fluorescent delta-opioid receptors uncover G protein-coupled receptor dynamics in vivo. Proc Natl Acad Sci U S A. 2006 Jun 20; 103(25):9691-6.
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      51. Basbaum AI, Julius D. Toward better pain control. Sci Am. 2006 Jun; 294(6):60-7.
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      52. Woods AS, Kaminski R, Oz M, Wang Y, Hauser K, Goody R, Wang HY, Jackson SN, Zeitz P, Zeitz KP, Zolkowska D, Schepers R, Nold M, Danielson J, Gräslund A, Vukojevic V, Bakalkin G, Basbaum A, Shippenberg T. Decoy peptides that bind dynorphin noncovalently prevent NMDA receptor-mediated neurotoxicity. J Proteome Res. 2006 Apr; 5(4):1017-23.
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      53. Villeda SA, Akopians AL, Babayan AH, Basbaum AI, Phelps PE. Absence of Reelin results in altered nociception and aberrant neuronal positioning in the dorsal spinal cord. Neuroscience. 2006; 139(4):1385-96.
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      54. Bautista DM, Jordt SE, Nikai T, Tsuruda PR, Read AJ, Poblete J, Yamoah EN, Basbaum AI, Julius D. TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents. Cell. 2006 Mar 24; 124(6):1269-82.
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      55. Neumann S, Skinner K, Basbaum AI. Sustaining intrinsic growth capacity of adult neurons promotes spinal cord regeneration. Proc Natl Acad Sci U S A. 2005 Nov 15; 102(46):16848-52.
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      56. Braz JM, Nassar MA, Wood JN, Basbaum AI. Parallel "pain" pathways arise from subpopulations of primary afferent nociceptor. Neuron. 2005 Sep 15; 47(6):787-93.
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      57. Julius D, Basbaum AI. A neuropeptide courier for delta-opioid receptors? Cell. 2005 Aug 26; 122(4):496-8.
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      58. Högestätt ED, Jönsson BA, Ermund A, Andersson DA, Björk H, Alexander JP, Cravatt BF, Basbaum AI, Zygmunt PM. Conversion of acetaminophen to the bioactive N-acylphenolamine AM404 via fatty acid amide hydrolase-dependent arachidonic acid conjugation in the nervous system. J Biol Chem. 2005 Sep 9; 280(36):31405-12.
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      59. Ahn AH, Basbaum AI. Where do triptans act in the treatment of migraine? Pain. 2005 May; 115(1-2):1-4.
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      60. Basbaum AI. A new way to lose your nerve. Sci Aging Knowledge Environ. 2004 Apr 14; 2004(15):pe15.
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      61. Sanderson Nydahl K, Skinner K, Julius D, Basbaum AI. Co-localization of endomorphin-2 and substance P in primary afferent nociceptors and effects of injury: a light and electron microscopic study in the rat. Eur J Neurosci. 2004 Apr; 19(7):1789-99.
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      62. Lewinter RD, Skinner K, Julius D, Basbaum AI. Immunoreactive TRPV-2 (VRL-1), a capsaicin receptor homolog, in the spinal cord of the rat. J Comp Neurol. 2004 Mar 15; 470(4):400-8.
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      63. Martin WJ, Cao Y, Basbaum AI. Characterization of wide dynamic range neurons in the deep dorsal horn of the spinal cord in preprotachykinin-a null mice in vivo. J Neurophysiol. 2004 May; 91(5):1945-54.
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      64. Trafton JA, Basbaum AI. [d-Ala2,N-MePhe4,Gly-ol5]enkephalin-induced internalization of the micro opioid receptor in the spinal cord of morphine tolerant rats. Neuroscience. 2004; 125(3):541-3.
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      65. Zeitz KP, Giese KP, Silva AJ, Basbaum AI. The contribution of autophosphorylated alpha-calcium-calmodulin kinase II to injury-induced persistent pain. Neuroscience. 2004; 128(4):889-98.
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      66. Potrebic S, Ahn AH, Skinner K, Fields HL, Basbaum AI. Peptidergic nociceptors of both trigeminal and dorsal root ganglia express serotonin 1D receptors: implications for the selective antimigraine action of triptans. J Neurosci. 2003 Nov 26; 23(34):10988-97.
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      67. Shields SD, Eckert WA, Basbaum AI. Spared nerve injury model of neuropathic pain in the mouse: a behavioral and anatomic analysis. J Pain. 2003 Oct; 4(8):465-70.
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      68. Taylor BK, Basbaum AI. Systemic morphine-induced release of serotonin in the rostroventral medulla is not mimicked by morphine microinjection into the periaqueductal gray. J Neurochem. 2003 Sep; 86(5):1129-41.
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      69. Bhatia M, Slavin J, Cao Y, Basbaum AI, Neoptolemos JP. Preprotachykinin-A gene deletion protects mice against acute pancreatitis and associated lung injury. Am J Physiol Gastrointest Liver Physiol. 2003 May; 284(5):G830-6.
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      70. Malmberg AB, Gilbert H, McCabe RT, Basbaum AI. Powerful antinociceptive effects of the cone snail venom-derived subtype-selective NMDA receptor antagonists conantokins G and T. Pain. 2003 Jan; 101(1-2):109-16.
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      71. Mitrovic I, Margeta-Mitrovic M, Bader S, Stoffel M, Jan LY, Basbaum AI. Contribution of GIRK2-mediated postsynaptic signaling to opiate and alpha 2-adrenergic analgesia and analgesic sex differences. Proc Natl Acad Sci U S A. 2003 Jan 7; 100(1):271-6.
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      72. Braz JM, Rico B, Basbaum AI. Transneuronal tracing of diverse CNS circuits by Cre-mediated induction of wheat germ agglutinin in transgenic mice. Proc Natl Acad Sci U S A. 2002 Nov 12; 99(23):15148-53.
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      73. Telgkamp P, Cao YQ, Basbaum AI, Ramirez JM. Long-term deprivation of substance P in PPT-A mutant mice alters the anoxic response of the isolated respiratory network. J Neurophysiol. 2002 Jul; 88(1):206-13.
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      74. Neumann S, Bradke F, Tessier-Lavigne M, Basbaum AI. Regeneration of sensory axons within the injured spinal cord induced by intraganglionic cAMP elevation. Neuron. 2002 Jun 13; 34(6):885-93.
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      75. Abbadie C, Lombard MC, Besson JM, Trafton JA, Basbaum AI. Mu and delta opioid receptor-like immunoreactivity in the cervical spinal cord of the rat after dorsal rhizotomy or neonatal capsaicin: an analysis of pre- and postsynaptic receptor distributions. Brain Res. 2002 Mar 15; 930(1-2):150-62.
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      76. Zeitz KP, Guy N, Malmberg AB, Dirajlal S, Martin WJ, Sun L, Bonhaus DW, Stucky CL, Julius D, Basbaum AI. The 5-HT3 subtype of serotonin receptor contributes to nociceptive processing via a novel subset of myelinated and unmyelinated nociceptors. J Neurosci. 2002 Feb 1; 22(3):1010-9.
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      77. Zeitz KP, Malmberg AB, Gilbert H, Basbaum AI. Reduced development of tolerance to the analgesic effects of morphine and clonidine in PKC gamma mutant mice. Pain. 2001 Dec; 94(3):245-53.
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      78. Kiss S, Yoshiyama M, Cao YQ, Basbaum AI, de Groat WC, Lecci A, Maggi CA, Birder LA. Impaired response to chemical irritation of the urinary tract in mice with disruption of the preprotachykinin gene. Neurosci Lett. 2001 Nov 2; 313(1-2):57-60.
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      79. Julius D, Basbaum AI. Molecular mechanisms of nociception. Nature. 2001 Sep 13; 413(6852):203-10.
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      80. Chen ZF, Rebelo S, White F, Malmberg AB, Baba H, Lima D, Woolf CJ, Basbaum AI, Anderson DJ. The paired homeodomain protein DRG11 is required for the projection of cutaneous sensory afferent fibers to the dorsal spinal cord. Neuron. 2001 Jul 19; 31(1):59-73.
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      81. Martin WJ, Malmberg AB, Basbaum AI. PKCgamma contributes to a subset of the NMDA-dependent spinal circuits that underlie injury-induced persistent pain. J Neurosci. 2001 Jul 15; 21(14):5321-7.
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      82. Vergnolle N, Bunnett NW, Sharkey KA, Brussee V, Compton SJ, Grady EF, Cirino G, Gerard N, Basbaum AI, Andrade-Gordon P, Hollenberg MD, Wallace JL. Proteinase-activated receptor-2 and hyperalgesia: A novel pain pathway. Nat Med. 2001 Jul; 7(7):821-6.
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      83. Chuang HH, Prescott ED, Kong H, Shields S, Jordt SE, Basbaum AI, Chao MV, Julius D. Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition. Nature. 2001 Jun 21; 411(6840):957-62.
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      84. Trafton JA, Abbadie C, Basbaum AI. Differential contribution of substance P and neurokinin A to spinal cord neurokinin-1 receptor signaling in the rat. J Neurosci. 2001 May 15; 21(10):3656-64.
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      85. Malmberg AB, Hedley LR, Jasper JR, Hunter JC, Basbaum AI. Contribution of alpha(2) receptor subtypes to nerve injury-induced pain and its regulation by dexmedetomidine. Br J Pharmacol. 2001 Apr; 132(8):1827-36.
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      86. Taylor BK, Roderick RE, St Lezin E, Basbaum AI. Hypoalgesia and hyperalgesia with inherited hypertension in the rat. Am J Physiol Regul Integr Comp Physiol. 2001 Feb; 280(2):R345-54.
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      87. Riley RC, Trafton JA, Chi SI, Basbaum AI. Presynaptic regulation of spinal cord tachykinin signaling via GABA(B) but not GABA(A) receptor activation. Neuroscience. 2001; 103(3):725-37.
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      88. Trafton JA, Abbadie C, Marek K, Basbaum AI. Postsynaptic signaling via the [mu]-opioid receptor: responses of dorsal horn neurons to exogenous opioids and noxious stimulation. J Neurosci. 2000 Dec 1; 20(23):8578-84.
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      89. Taylor BK, Roderick RE, Basbaum AI. Brainstem noradrenergic control of nociception is abnormal in the spontaneously hypertensive rat. Neurosci Lett. 2000 Sep 22; 291(3):139-42.
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      90. Trafton JA, Basbaum AI. The contribution of spinal cord neurokinin-1 receptor signaling to pain. J Pain. 2000 Sep; 1(3 Suppl):57-65.
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      91. Caterina MJ, Leffler A, Malmberg AB, Martin WJ, Trafton J, Petersen-Zeitz KR, Koltzenburg M, Basbaum AI, Julius D. Impaired nociception and pain sensation in mice lacking the capsaicin receptor. Science. 2000 Apr 14; 288(5464):306-13.
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      92. Taylor BK, Peterson MA, Roderick RE, Tate J, Green PG, Levine JO, Basbaum AI. Opioid inhibition of formalin-induced changes in plasma extravasation and local blood flow in rats. Pain. 2000 Feb; 84(2-3):263-70.
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      93. Taylor BK, Basbaum AI. Early antinociception delays edema but does not reduce the magnitude of persistent pain in the formalin test. J Pain. 2000; 1(3):218-28.
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      94. Mitchell JM, Basbaum AI, Fields HL. A locus and mechanism of action for associative morphine tolerance. Nat Neurosci. 2000 Jan; 3(1):47-53.
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      95. Mogil JS, Yu L, Basbaum AI. Pain genes?: natural variation and transgenic mutants. Annu Rev Neurosci. 2000; 23:777-811.
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      96. Trafton JA, Abbadie C, Marchand S, Mantyh PW, Basbaum AI. Spinal opioid analgesia: how critical is the regulation of substance P signaling? J Neurosci. 1999 Nov 1; 19(21):9642-53.
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      97. Stryker MP, Basbaum A, DeFranco T, Herskowitz I, Yamamoto K. Hospital merger leaves clinical science intact. Nature. 1999 Oct 28; 401(6756):842.
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      98. Liu H, Cao Y, Basbaum AI, Mazarati AM, Sankar R, Wasterlain CG. Resistance to excitotoxin-induced seizures and neuronal death in mice lacking the preprotachykinin A gene. Proc Natl Acad Sci U S A. 1999 Oct 12; 96(21):12096-101.
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      99. Honor P, Menning PM, Rogers SD, Nichols ML, Basbaum AI, Besson JM, Mantyh PW. Spinal substance P receptor expression and internalization in acute, short-term, and long-term inflammatory pain states. J Neurosci. 1999 Sep 1; 19(17):7670-8.
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      100. Petersen-Zeitz KR, Basbaum AI. Second messengers, the substantia gelatinosa and injury-induced persistent pain. Pain. 1999 Aug; Suppl 6:S5-12.
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      101. Martin WJ, Loo CM, Basbaum AI. Spinal cannabinoids are anti-allodynic in rats with persistent inflammation. Pain. 1999 Aug; 82(2):199-205.
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      102. Basbaum AI. Distinct neurochemical features of acute and persistent pain. Proc Natl Acad Sci U S A. 1999 Jul 6; 96(14):7739-43.
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      103. Basbaum AI, Woolf CJ. Pain. Curr Biol. 1999 Jun 17; 9(12):R429-31.
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      104. Margeta-Mitrovic M, Mitrovic I, Riley RC, Jan LY, Basbaum AI. Immunohistochemical localization of GABA(B) receptors in the rat central nervous system. J Comp Neurol. 1999 Mar 15; 405(3):299-321.
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      105. Martin WJ, Gupta NK, Loo CM, Rohde DS, Basbaum AI. Differential effects of neurotoxic destruction of descending noradrenergic pathways on acute and persistent nociceptive processing. Pain. 1999 Mar; 80(1-2):57-65.
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      106. Abbadie C, Skinner K, Mitrovic I, Basbaum AI. Neurons in the dorsal column white matter of the spinal cord: complex neuropil in an unexpected location. Proc Natl Acad Sci U S A. 1999 Jan 5; 96(1):260-5.
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      107. Martin WJ, Liu H, Wang H, Malmberg AB, Basbaum AI. Inflammation-induced up-regulation of protein kinase Cgamma immunoreactivity in rat spinal cord correlates with enhanced nociceptive processing. Neuroscience. 1999; 88(4):1267-74.
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      108. Basbaum AI. Spinal mechanisms of acute and persistent pain. Reg Anesth Pain Med. 1999 Jan-Feb; 24(1):59-67.
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      109. Abbadie C, Basbaum AI. The contribution of capsaicin-sensitive afferents to the dorsal root ganglion sprouting of sympathetic axons after peripheral nerve injury in the rat. Neurosci Lett. 1998 Sep 11; 253(3):143-6.
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      110. Tominaga M, Caterina MJ, Malmberg AB, Rosen TA, Gilbert H, Skinner K, Raumann BE, Basbaum AI, Julius D. The cloned capsaicin receptor integrates multiple pain-producing stimuli. Neuron. 1998 Sep; 21(3):531-43.
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      111. Martin WJ, Malmberg AB, Basbaum AI. Pain: nocistatin spells relief. Curr Biol. 1998 Jul 16; 8(15):R525-7.
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      112. Bhatnagar S, Dallman MF, Roderick RE, Basbaum AI, Taylor BK. The effects of prior chronic stress on cardiovascular responses to acute restraint and formalin injection. Brain Res. 1998 Jun 29; 797(2):313-20.
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      113. Rohde DS, Basbaum AI. Activation of coeruleospinal noradrenergic inhibitory controls during withdrawal from morphine in the rat. J Neurosci. 1998 Jun 1; 18(11):4393-402.
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      114. Malmberg AB, Basbaum AI. Partial sciatic nerve injury in the mouse as a model of neuropathic pain: behavioral and neuroanatomical correlates. Pain. 1998 May; 76(1-2):215-22.
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      115. Taylor BK, Akana SF, Peterson MA, Dallman MF, Basbaum AI. Pituitary-adrenocortical responses to persistent noxious stimuli in the awake rat: endogenous corticosterone does not reduce nociception in the formalin test. Endocrinology. 1998 May; 139(5):2407-13.
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      116. Cao YQ, Mantyh PW, Carlson EJ, Gillespie AM, Epstein CJ, Basbaum AI. Primary afferent tachykinins are required to experience moderate to intense pain. Nature. 1998 Mar 26; 392(6674):390-4.
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      117. Hammond DL, Wang H, Nakashima N, Basbaum AI. Differential effects of intrathecally administered delta and mu opioid receptor agonists on formalin-evoked nociception and on the expression of Fos-like immunoreactivity in the spinal cord of the rat. J Pharmacol Exp Ther. 1998 Jan; 284(1):378-87.
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      118. Abbadie C, Trafton J, Liu H, Mantyh PW, Basbaum AI. Inflammation increases the distribution of dorsal horn neurons that internalize the neurokinin-1 receptor in response to noxious and non-noxious stimulation. J Neurosci. 1997 Oct 15; 17(20):8049-60.
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      119. Malmberg AB, Chen C, Tonegawa S, Basbaum AI. Preserved acute pain and reduced neuropathic pain in mice lacking PKCgamma. Science. 1997 Oct 10; 278(5336):279-83.
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      120. Malmberg AB, Brandon EP, Idzerda RL, Liu H, McKnight GS, Basbaum AI. Diminished inflammation and nociceptive pain with preservation of neuropathic pain in mice with a targeted mutation of the type I regulatory subunit of cAMP-dependent protein kinase. J Neurosci. 1997 Oct 1; 17(19):7462-70.
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      121. Skinner K, Basbaum AI, Fields HL. Cholecystokinin and enkephalin in brain stem pain modulating circuits. Neuroreport. 1997 Sep 29; 8(14):2995-8.
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      122. Rohde DS, McKay WR, Chang DS, Abbadie C, Basbaum AI. The contribution of supraspinal, peripheral and intrinsic spinal circuits to the pattern and magnitude of Fos-like immunoreactivity in the lumbar spinal cord of the rat withdrawing from morphine. Neuroscience. 1997 Sep; 80(2):599-612.
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      123. Rohde DS, Detweiler DJ, Basbaum AI. Formalin-evoked Fos expression in spinal cord is enhanced in morphine-tolerant rats. Brain Res. 1997 Aug 22; 766(1-2):93-100.
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      124. Allen BJ, Rogers SD, Ghilardi JR, Menning PM, Kuskowski MA, Basbaum AI, Simone DA, Mantyh PW. Noxious cutaneous thermal stimuli induce a graded release of endogenous substance P in the spinal cord: imaging peptide action in vivo. J Neurosci. 1997 Aug 1; 17(15):5921-7.
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      125. Jasmin L, Burkey AR, Card JP, Basbaum AI. Transneuronal labeling of a nociceptive pathway, the spino-(trigemino-)parabrachio-amygdaloid, in the rat. J Neurosci. 1997 May 15; 17(10):3751-65.
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      126. Peterson MA, Basbaum AI, Abbadie C, Rohde DS, McKay WR, Taylor BK. The differential contribution of capsaicin-sensitive afferents to behavioral and cardiovascular measures of brief and persistent nociception and to Fos expression in the formalin test. Brain Res. 1997 Apr 25; 755(1):9-16.
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      127. Liu H, Mantyh PW, Basbaum AI. NMDA-receptor regulation of substance P release from primary afferent nociceptors. Nature. 1997 Apr 17; 386(6626):721-4.
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      128. Llewellyn-Smith IJ, Martin CL, Minson JB, Pilowsky PM, Arnolda LF, Basbaum AI, Chalmers JP. Neurokinin-1 receptor-immunoreactive sympathetic preganglionic neurons: target specificity and ultrastructure. Neuroscience. 1997 Apr; 77(4):1137-49.
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      129. Skinner K, Fields HL, Basbaum AI, Mason P. GABA-immunoreactive boutons contact identified OFF and ON cells in the nucleus raphe magnus. J Comp Neurol. 1997 Feb 10; 378(2):196-204.
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      130. Taylor BK, Peterson MA, Basbaum AI. Early nociceptive events influence the temporal profile, but not the magnitude, of the tonic response to subcutaneous formalin: effects with remifentanil. J Pharmacol Exp Ther. 1997 Feb; 280(2):876-83.
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      131. Jasmin L, Carstens E, Basbaum AI. Interneurons presynaptic to rat tail-flick motoneurons as mapped by transneuronal transport of pseudorabies virus: few have long ascending collaterals. Neuroscience. 1997 Feb; 76(3):859-76.
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      132. Rohde DS, McKay WR, Abbadie C, Basbaum AI. Contribution of sacral spinal cord neurons to the autonomic and somatic consequences of withdrawal from morphine in the rat. Brain Res. 1997 Jan 16; 745(1-2):83-95.
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      133. Abbadie C, Taylor BK, Peterson MA, Basbaum AI. Differential contribution of the two phases of the formalin test to the pattern of c-fos expression in the rat spinal cord: studies with remifentanil and lidocaine. Pain. 1997 Jan; 69(1-2):101-10.
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      134. Taylor BK, Peterson MA, Basbaum AI. Continuous intravenous infusion of naloxone does not change behavioral, cardiovascular, or inflammatory responses to subcutaneous formalin in the rat. Pain. 1997 Jan; 69(1-2):171-7.
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      135. Rohde DS, Detweiler DJ, Basbaum AI. Spinal cord mechanisms of opioid tolerance and dependence: Fos-like immunoreactivity increases in subpopulations of spinal cord neurons during withdrawal [corrected]. Neuroscience. 1996 May; 72(1):233-42.
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      136. Gogas KR, Cho HJ, Botchkina GI, Levine JD, Basbaum AI. Inhibition of noxious stimulus-evoked pain behaviors and neuronal fos-like immunoreactivity in the spinal cord of the rat by supraspinal morphine. Pain. 1996 Apr; 65(1):9-15.
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      137. Gogas KR, Levine JD, Basbaum AI. Differential contribution of descending controls to the antinociceptive actions of kappa and mu opioids: an analysis of formalin-evoked C-fos expression. J Pharmacol Exp Ther. 1996 Feb; 276(2):801-9.
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      138. Abbadie C, Brown JL, Mantyh PW, Basbaum AI. Spinal cord substance P receptor immunoreactivity increases in both inflammatory and nerve injury models of persistent pain. Neuroscience. 1996 Jan; 70(1):201-9.
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      139. Taylor BK, Peterson MA, Basbaum AI. Exaggerated cardiovascular and behavioral nociceptive responses to subcutaneous formalin in the spontaneously hypertensive rat. Neurosci Lett. 1995 Dec 1; 201(1):9-12.
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      140. Detweiler DJ, Rohde DS, Basbaum AI. The development of opioid tolerance in the formalin test in the rat. Pain. 1995 Nov; 63(2):251-4.
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      141. Taylor BK, Peterson MA, Basbaum AI. Persistent cardiovascular and behavioral nociceptive responses to subcutaneous formalin require peripheral nerve input. J Neurosci. 1995 Nov; 15(11):7575-84.
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      142. Matos FF, Rollema H, Taiwo YO, Levine JD, Basbaum AI. Relationship between analgesia and extracellular morphine in brain and spinal cord in awake rats. Brain Res. 1995 Sep 25; 693(1-2):187-95.
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      143. Taylor BK, Basbaum AI. Neurochemical characterization of extracellular serotonin in the rostral ventromedial medulla and its modulation by noxious stimuli. J Neurochem. 1995 Aug; 65(2):578-89.
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      144. Mantyh PW, DeMaster E, Malhotra A, Ghilardi JR, Rogers SD, Mantyh CR, Liu H, Basbaum AI, Vigna SR, Maggio JE, et al. Receptor endocytosis and dendrite reshaping in spinal neurons after somatosensory stimulation. Science. 1995 Jun 16; 268(5217):1629-32.
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      145. Brown JL, Liu H, Maggio JE, Vigna SR, Mantyh PW, Basbaum AI. Morphological characterization of substance P receptor-immunoreactive neurons in the rat spinal cord and trigeminal nucleus caudalis. J Comp Neurol. 1995 Jun 5; 356(3):327-44.
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      146. Basbaum AI. Insights into the development of opioid tolerance. Pain. 1995 Jun; 61(3):349-52.
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      147. Liu H, Llewellyn-Smith IJ, Basbaum AI. Co-injection of wheat germ agglutinin-HRP and choleragenoid-HRP into the sciatic nerve of the rat blocks transganglionic transport. J Histochem Cytochem. 1995 May; 43(5):489-95.
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      148. Mantyh PW, Allen CJ, Ghilardi JR, Rogers SD, Mantyh CR, Liu H, Basbaum AI, Vigna SR, Maggio JE. Rapid endocytosis of a G protein-coupled receptor: substance P evoked internalization of its receptor in the rat striatum in vivo. Proc Natl Acad Sci U S A. 1995 Mar 28; 92(7):2622-6.
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      149. Jasmin L, Wang H, Tarczy-Hornoch K, Levine JD, Basbaum AI. Differential effects of morphine on noxious stimulus-evoked fos-like immunoreactivity in subpopulations of spinoparabrachial neurons. J Neurosci. 1994 Dec; 14(12):7252-60.
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      150. Miao FJ, Jänig W, Dallman MF, Benowitz NL, Heller PH, Basbaum AI, Levine JD. Role of vagal afferents and spinal pathways modulating inhibition of bradykinin-induced plasma extravasation by intrathecal nicotine. J Neurophysiol. 1994 Sep; 72(3):1199-207.
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      151. Liu H, Wang H, Sheng M, Jan LY, Jan YN, Basbaum AI. Evidence for presynaptic N-methyl-D-aspartate autoreceptors in the spinal cord dorsal horn. Proc Natl Acad Sci U S A. 1994 Aug 30; 91(18):8383-7.
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      152. Morgan MM, Gogas KR, Basbaum AI. Diffuse noxious inhibitory controls reduce the expression of noxious stimulus-evoked Fos-like immunoreactivity in the superficial and deep laminae of the rat spinal cord. Pain. 1994 Mar; 56(3):347-52.
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      153. Liu H, Brown JL, Jasmin L, Maggio JE, Vigna SR, Mantyh PW, Basbaum AI. Synaptic relationship between substance P and the substance P receptor: light and electron microscopic characterization of the mismatch between neuropeptides and their receptors. Proc Natl Acad Sci U S A. 1994 Feb 1; 91(3):1009-13.
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      154. Jasmin L, Gogas KR, Ahlgren SC, Levine JD, Basbaum AI. Walking evokes a distinctive pattern of Fos-like immunoreactivity in the caudal brainstem and spinal cord of the rat. Neuroscience. 1994 Jan; 58(2):275-86.
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      155. Jasmin L, Tarczy-Hornoch K, Wang H, Levine JD, Basbaum AI. Transneuronal spread of the pseudorabies virus after injection into the central nucleus of the amygdala in the rat. Gene Ther. 1994; 1 Suppl 1:S74.
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      156. Chi SI, Levine JD, Basbaum AI. Peripheral and central contributions to the persistent expression of spinal cord fos-like immunoreactivity produced by sciatic nerve transection in the rat. Brain Res. 1993 Jul 23; 617(2):225-37.
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      157. Chi SI, Levine JD, Basbaum AI. Effects of injury discharge on the persistent expression of spinal cord fos-like immunoreactivity produced by sciatic nerve transection in the rat. Brain Res. 1993 Jul 23; 617(2):220-4.
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      158. Levine JD, Fields HL, Basbaum AI. Peptides and the primary afferent nociceptor. J Neurosci. 1993 Jun; 13(6):2273-86.
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      159. Kwiat GC, Liu H, Williamson AM, Basbaum AI. GABAergic regulation of noradrenergic spinal projection neurons of the A5 cell group in the rat: an electron microscopic analysis. J Comp Neurol. 1993 Apr 22; 330(4):557-70.
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      160. Miao FJ, Dallman MF, Benowitz NL, Basbaum AI, Levine JD. Adrenal medullary modulation of the inhibition of bradykinin-induced plasma extravasation by intrathecal nicotine. J Pharmacol Exp Ther. 1993 Feb; 264(2):839-44.
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      161. Gogas KR, Levine JD, Basbaum AI. Mechanisms of opioid-mediated antinociception: correlation of Fos expression and behavior. NIDA Res Monogr. 1993; 125:134-60.
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      162. Miao FJ, Helms C, Benowitz NL, Basbaum AI, Heller PH, Levine JD. Chronically administered nicotine attenuates bradykinin-induced plasma extravasation and aggravates arthritis-induced joint injury in the rat. Neuroscience. 1992 Dec; 51(3):649-55.
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      163. Green PG, Basbaum AI, Levine JD. Sensory neuropeptide interactions in the production of plasma extravasation in the rat. Neuroscience. 1992 Oct; 50(3):745-9.
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      164. Miao FJ, Benowitz NL, Basbaum AI, Levine JD. Sympathoadrenal contribution to nicotinic and muscarinic modulation of bradykinin-induced plasma extravasation in the knee joint of the rat. J Pharmacol Exp Ther. 1992 Sep; 262(3):889-95.
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      165. Frothingham EP, Basbaum AI. Construction of a microdialysis probe with attached microinjection catheter. J Neurosci Methods. 1992 Jul; 43(2-3):181-8.
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      166. Sato M, Severinghaus JW, Basbaum AI. Medullary CO2 chemoreceptor neuron identification by c-fos immunocytochemistry. J Appl Physiol (1985). 1992 Jul; 73(1):96-100.
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      167. Matos FF, Rollema H, Basbaum AI. Simultaneous measurement of extracellular morphine and serotonin in brain tissue and CSF by microdialysis in awake rats. J Neurochem. 1992 May; 58(5):1773-81.
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      168. Liu H, Llewellyn-Smith IJ, Pilowsky P, Basbaum AI. Ultrastructural evidence for GABA-mediated disinhibitory circuits in the spinal cord of the cat. Neurosci Lett. 1992 Apr 13; 138(1):183-7.
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      169. Matos FF, Rollema H, Brown JL, Basbaum AI. Do opioids evoke the release of serotonin in the spinal cord? An in vivo microdialysis study of the regulation of extracellular serotonin in the rat. Pain. 1992 Mar; 48(3):439-47.
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      170. Hammond DL, Presley R, Gogas KR, Basbaum AI. Morphine or U-50,488 suppresses Fos protein-like immunoreactivity in the spinal cord and nucleus tractus solitarii evoked by a noxious visceral stimulus in the rat. J Comp Neurol. 1992 Jan 8; 315(2):244-53.
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      171. Kwiat GC, Basbaum AI. The origin of brainstem noradrenergic and serotonergic projections to the spinal cord dorsal horn in the rat. Somatosens Mot Res. 1992; 9(2):157-73.
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      172. Basbaum AI. Opioid regulation of nociceptive and neuropathic pain. Clin Neuropharmacol. 1992; 15 Suppl 1 Pt A:372A.
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      173. Basbaum AI, Gautron M, Jazat F, Mayes M, Guilbaud G. The spectrum of fiber loss in a model of neuropathic pain in the rat: an electron microscopic study. Pain. 1991 Dec; 47(3):359-67.
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      174. Basbaum AI, Levine JD. Opiate analgesia. How central is a peripheral target? N Engl J Med. 1991 Oct 17; 325(16):1168-9.
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      175. Lee A, Coderre TJ, Basbaum AI, Levine JD. Sympathetic neuron factors involved in bradykinin-induced plasma extravasation in the rat. Brain Res. 1991 Aug 23; 557(1-2):146-8.
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      176. Green PG, Basbaum AI, Helms C, Levine JD. Purinergic regulation of bradykinin-induced plasma extravasation and adjuvant-induced arthritis in the rat. Proc Natl Acad Sci U S A. 1991 May 15; 88(10):4162-5.
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      177. Basbaum AI, Levine JD. The contribution of the nervous system to inflammation and inflammatory disease. Can J Physiol Pharmacol. 1991 May; 69(5):647-51.
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      178. Coderre TJ, Basbaum AI, Helms C, Levine JD. High-dose epinephrine acts at alpha 2-adrenoceptors to suppress experimental arthritis. Brain Res. 1991 Mar 29; 544(2):325-8.
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      179. Cho HJ, Basbaum AI. GABAergic circuitry in the rostral ventral medulla of the rat and its relationship to descending antinociceptive controls. J Comp Neurol. 1991 Jan 8; 303(2):316-28.
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      180. Gogas KR, Presley RW, Levine JD, Basbaum AI. The antinociceptive action of supraspinal opioids results from an increase in descending inhibitory control: correlation of nociceptive behavior and c-fos expression. Neuroscience. 1991; 42(3):617-28.
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      181. Bjerknes L, Coderre TJ, Green PG, Basbaum AI, Levine JD. Neutrophils contribute to sympathetic nerve terminal-dependent plasma extravasation in the knee joint of the rat. Neuroscience. 1991; 43(2-3):679-85.
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      182. Coderre TJ, Chan AK, Helms C, Basbaum AI, Levine JD. Increasing sympathetic nerve terminal-dependent plasma extravasation correlates with decreased arthritic joint injury in rats. Neuroscience. 1991; 40(1):185-9.
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      183. Reichling DB, Basbaum AI. Collateralization of periaqueductal gray neurons to forebrain or diencephalon and to the medullary nucleus raphe magnus in the rat. Neuroscience. 1991; 42(1):183-200.
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      184. Reichling DB, Basbaum AI. Contribution of brainstem GABAergic circuitry to descending antinociceptive controls: I. GABA-immunoreactive projection neurons in the periaqueductal gray and nucleus raphe magnus. J Comp Neurol. 1990 Dec 8; 302(2):370-7.
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      185. Reichling DB, Basbaum AI. Contribution of brainstem GABAergic circuitry to descending antinociceptive controls: II. Electron microscopic immunocytochemical evidence of GABAergic control over the projection from the periaqueductal gray to the nucleus raphe magnus in the rat. J Comp Neurol. 1990 Dec 8; 302(2):378-93.
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      186. Levine JD, Coderre TJ, White DM, Finkbeiner WE, Basbaum AI. Denervation-induced inflammation in the rat. Neurosci Lett. 1990 Oct 30; 119(1):37-40.
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      187. Matos FF, Rollema H, Basbaum AI. Characterization of monoamine release in the lateral hypothalamus of awake, freely moving rats using in vivo microdialysis. Brain Res. 1990 Sep 24; 528(1):39-47.
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      188. Kwiat GC, Basbaum AI. Organization of tyrosine hydroxylase- and serotonin-immunoreactive brainstem neurons with axon collaterals to the periaqueductal gray and the spinal cord in the rat. Brain Res. 1990 Sep 24; 528(1):83-94.
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      189. Levine JD, Coderre TJ, Covinsky K, Basbaum AI. Neural influences on synovial mast cell density in rat. J Neurosci Res. 1990 Jul; 26(3):301-7.
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      190. White DM, Basbaum AI, Goetzl EJ, Levine JD. The 15-lipoxygenase product, 8R,15S-diHETE, stereospecifically sensitizes C-fiber mechanoheat nociceptors in hairy skin of rat. J Neurophysiol. 1990 May; 63(5):966-70.
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      191. Levine JD, Basbaum AI. Neurogenic mechanism for symmetrical arthritis. Lancet. 1990 Mar 31; 335(8692):795.
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      192. Kayser V, Basbaum AI, Guilbaud G. Deafferentation in the rat increases mechanical nociceptive threshold in the innervated limbs. Brain Res. 1990 Feb 5; 508(2):329-32.
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      193. Coderre TJ, Basbaum AI, Dallman MF, Helms C, Levine JD. Epinephrine exacerbates arthritis by an action at presynaptic B2-adrenoceptors. Neuroscience. 1990; 34(2):521-3.
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      194. Presley RW, Menétrey D, Levine JD, Basbaum AI. Systemic morphine suppresses noxious stimulus-evoked Fos protein-like immunoreactivity in the rat spinal cord. J Neurosci. 1990 Jan; 10(1):323-35.
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      195. Basbaum AI. A rapid and simple silver enhancement procedure for ultrastructural localization of the retrograde tracer WGAapoHRP-Au and its use in double-label studies with post-embedding immunocytochemistry. J Histochem Cytochem. 1989 Dec; 37(12):1811-5.
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      196. Menétrey D, Gannon A, Levine JD, Basbaum AI. Expression of c-fos protein in interneurons and projection neurons of the rat spinal cord in response to noxious somatic, articular, and visceral stimulation. J Comp Neurol. 1989 Jul 8; 285(2):177-95.
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      197. Coderre TJ, Basbaum AI, Levine JD. Neural control of vascular permeability: interactions between primary afferents, mast cells, and sympathetic efferents. J Neurophysiol. 1989 Jul; 62(1):48-58.
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      198. Weil-Fugazza J, Godefroy F, Basbaum AI. Effect of deafferentation on the levels of uric acid in the spinal cord of the rat. Neurosci Lett. 1989 Apr 24; 99(1-2):181-6.
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      199. Taiwo YO, Basbaum AI, Perry F, Levine JD. Paradoxical analgesia produced by low doses of the opiate-antagonist naloxone is mediated by interaction at a site with characteristics of the delta opioid receptor. J Pharmacol Exp Ther. 1989 Apr; 249(1):97-100.
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      200. Cho HJ, Basbaum AI. Ultrastructural analysis of dynorphin B-immunoreactive cells and terminals in the superficial dorsal horn of the deafferented spinal cord of the rat. J Comp Neurol. 1989 Mar 8; 281(2):193-205.
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      201. Cho HJ, Basbaum AI. Arborization of single axons of the spinal dorsolateral funiculus to the contralateral superficial dorsal horn. Brain Res. 1989 Jan 16; 477(1-2):344-9.
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      202. Basbaum AI. Distribution of glycine receptor immunoreactivity in the spinal cord of the rat: cytochemical evidence for a differential glycinergic control of lamina I and V nociceptive neurons. J Comp Neurol. 1988 Dec 15; 278(3):330-6.
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      203. Martin HA, Basbaum AI, Goetzl EJ, Levine JD. Leukotriene B4 decreases the mechanical and thermal thresholds of C-fiber nociceptors in the hairy skin of the rat. J Neurophysiol. 1988 Aug; 60(2):438-45.
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      204. Levine JD, Coderre TJ, Helms C, Basbaum AI. Beta 2-adrenergic mechanisms in experimental arthritis. Proc Natl Acad Sci U S A. 1988 Jun; 85(12):4553-6.
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      205. Faden AI, Gannon A, Basbaum AI. Use of serotonin immunocytochemistry as a marker of injury severity after experimental spinal trauma in rats. Brain Res. 1988 May 31; 450(1-2):94-100.
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      206. Levine JD, Moskowitz MA, Basbaum AI. The effect of gold, an antirheumatic therapy, on substance P levels in rat peripheral nerve. Neurosci Lett. 1988 Apr 22; 87(1-2):200-2.
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      207. Lakos S, Basbaum AI. An ultrastructural study of the projections from the midbrain periaqueductal gray to spinally projecting, serotonin-immunoreactive neurons of the medullary nucleus raphe magnus in the rat. Brain Res. 1988 Mar 8; 443(1-2):383-8.
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      208. Cho HJ, Basbaum AI. Increased staining of immunoreactive dynorphin cell bodies in the deafferented spinal cord of the rat. Neurosci Lett. 1988 Jan 22; 84(2):125-30.
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      209. Reichling DB, Kwiat GC, Basbaum AI. Anatomy, physiology and pharmacology of the periaqueductal gray contribution to antinociceptive controls. Prog Brain Res. 1988; 77:31-46.
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      210. Basbaum AI. Anatomical introduction to analgesia: correlation of activity of neurons of the superficial dorsal horn with pain and analgesia. Acta Anaesthesiol Belg. 1988; 39(3 Suppl 2):45-6.
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      211. Basbaum AI, Zahs K, Lord B, Lakos S. The fiber caliber of 5-HT immunoreactive axons in the dorsolateral funiculus of the spinal cord of the rat and cat. Somatosens Res. 1988; 5(3):177-85.
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      212. Daval G, Vergé D, Basbaum AI, Bourgoin S, Hamon M. Autoradiographic evidence of serotonin1 binding sites on primary afferent fibres in the dorsal horn of the rat spinal cord. Neurosci Lett. 1987 Dec 16; 83(1-2):71-6.
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      213. Menetrey D, Basbaum AI. The distribution of substance P-, enkephalin- and dynorphin-immunoreactive neurons in the medulla of the rat and their contribution to bulbospinal pathways. Neuroscience. 1987 Oct; 23(1):173-87.
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      214. Basbaum AI, Godefroy F, Weil-Fugazza J. A new microdissection technique for regional biochemical analysis of the rat spinal cord: serotonin, norepinephrine, dopamine and uric acid. Brain Res. 1987 Sep 1; 419(1-2):229-38.
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      215. Levine JD, Goetzl EJ, Basbaum AI. Contribution of the nervous system to the pathophysiology of rheumatoid arthritis and other polyarthritides. Rheum Dis Clin North Am. 1987 Aug; 13(2):369-83.
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      216. Martin HA, Basbaum AI, Kwiat GC, Goetzl EJ, Levine JD. Leukotriene and prostaglandin sensitization of cutaneous high-threshold C- and A-delta mechanonociceptors in the hairy skin of rat hindlimbs. Neuroscience. 1987 Aug; 22(2):651-9.
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      217. Basbaum AI, Menetrey D. Wheat germ agglutinin-apoHRP gold: a new retrograde tracer for light- and electron-microscopic single- and double-label studies. J Comp Neurol. 1987 Jul 8; 261(2):306-18.
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      218. Mochly-Rosen D, Basbaum AI, Koshland DE. Distinct cellular and regional localization of immunoreactive protein kinase C in rat brain. Proc Natl Acad Sci U S A. 1987 Jul; 84(13):4660-4.
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      219. Menétrey D, Basbaum AI. Spinal and trigeminal projections to the nucleus of the solitary tract: a possible substrate for somatovisceral and viscerovisceral reflex activation. J Comp Neurol. 1987 Jan 15; 255(3):439-50.
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      220. Doble A, Malgouris C, Daniel M, Daniel N, Imbault F, Basbaum A, Uzan A, Guérémy C, Le Fur G. Labelling of peripheral-type benzodiazepine binding sites in human brain with [3H]PK 11195: anatomical and subcellular distribution. Brain Res Bull. 1987 Jan; 18(1):49-61.
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      221. Basbaum AI. Cytochemical studies of the neural circuitry underlying pain and pain control. Acta Neurochir Suppl (Wien). 1987; 38:5-15.
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      222. Levine JD, Dardick SJ, Roizen MF, Helms C, Basbaum AI. Contribution of sensory afferents and sympathetic efferents to joint injury in experimental arthritis. J Neurosci. 1986 Dec; 6(12):3423-9.
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      223. Levine JD, Fye K, Heller P, Basbaum AI, Whiting-O'Keefe Q. Clinical response to regional intravenous guanethidine in patients with rheumatoid arthritis. J Rheumatol. 1986 Dec; 13(6):1040-3.
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      224. Basbaum AI, Ralston DD, Ralston HJ. Bulbospinal projections in the primate: a light and electron microscopic study of a pain modulating system. J Comp Neurol. 1986 Aug 15; 250(3):311-23.
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      225. Dardick SJ, Basbaum AI, Levine JD. The contribution of pain to disability in experimentally induced arthritis. Arthritis Rheum. 1986 Aug; 29(8):1017-22.
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      226. Lakos S, Basbaum AI. Benzidine dihydrochloride as a chromogen for single- and double-label light and electron microscopic immunocytochemical studies. J Histochem Cytochem. 1986 Aug; 34(8):1047-56.
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      227. Levine JD, Goldstine J, Mayes M, Moskowitz MA, Basbaum AI. The neurotoxic effect of gold sodium thiomalate on the peripheral nerves of the rat. Insights into the antiinflammatory actions of gold therapy. Arthritis Rheum. 1986 Jul; 29(7):897-901.
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      228. Basbaum AI, Glazer EJ, Oertel W. Immunoreactive glutamic acid decarboxylase in the trigeminal nucleus caudalis of the cat: a light- and electron-microscopic analysis. Somatosens Res. 1986; 4(1):77-94.
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      229. Basbaum AI, Cruz L, Weber E. Immunoreactive dynorphin B in sacral primary afferent fibers of the cat. J Neurosci. 1986 Jan; 6(1):127-33.
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      230. Brown RO, Gusman D, Basbaum AI, Mayeri E. Identification of Aplysia neurons containing immunoreactive FMRFamide. Neuropeptides. 1985 Dec; 6(6):517-26.
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      231. Cruz L, Basbaum AI. Multiple opioid peptides and the modulation of pain: immunohistochemical analysis of dynorphin and enkephalin in the trigeminal nucleus caudalis and spinal cord of the cat. J Comp Neurol. 1985 Oct 22; 240(4):331-48.
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      232. Levine JD, Moskowitz MA, Basbaum AI. The contribution of neurogenic inflammation in experimental arthritis. J Immunol. 1985 Aug; 135(2 Suppl):843s-847s.
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      233. Levine JD, Collier DH, Basbaum AI, Moskowitz MA, Helms CA. Hypothesis: the nervous system may contribute to the pathophysiology of rheumatoid arthritis. J Rheumatol. 1985 Jun; 12(3):406-11.
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      234. Levine JD, Dardick SJ, Basbaum AI, Scipio E. Reflex neurogenic inflammation. I. Contribution of the peripheral nervous system to spatially remote inflammatory responses that follow injury. J Neurosci. 1985 May; 5(5):1380-6.
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      235. Lee HS, Basbaum AI. Immunoreactive pro-enkephalin and prodynorphin products are differentially distributed within the nucleus of the solitary tract of the rat. J Comp Neurol. 1984 Dec 20; 230(4):614-9.
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      236. Levine JD, Clark R, Devor M, Helms C, Moskowitz MA, Basbaum AI. Intraneuronal substance P contributes to the severity of experimental arthritis. Science. 1984 Nov 2; 226(4674):547-9.
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      237. Guthrie J, Basbaum AI. Colocalization of immunoreactive proenkephalin and prodynorphin products in medullary neurons of the rat. Neuropeptides. 1984 Nov; 4(6):437-45.
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      238. Glazer EJ, Ramachandran J, Basbaum AI. Radioimmunocytochemistry using a tritiated goat anti-rabbit second antibody. J Histochem Cytochem. 1984 Jul; 32(7):778-82.
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      239. Glazer EJ, Basbaum AI. Axons which take up [3H]serotonin are presynaptic to enkephalin immunoreactive neurons in cat dorsal horn. Brain Res. 1984 Apr 30; 298(2):386-91.
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      240. Basbaum AI, Fields HL. Endogenous pain control systems: brainstem spinal pathways and endorphin circuitry. Annu Rev Neurosci. 1984; 7:309-38.
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      241. Moss MS, Basbaum AI. The fine structure of the caudal periaqueductal gray of the cat: morphology and synaptic organization of normal and immunoreactive enkephalin-labeled profiles. Brain Res. 1983 Dec 19; 289(1-2):27-43.
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      242. Glazer EJ, Basbaum AI. Opioid neurons and pain modulation: an ultrastructural analysis of enkephalin in cat superficial dorsal horn. Neuroscience. 1983 Oct; 10(2):357-76.
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      243. Moss MS, Basbaum AI. The peptidergic organization of the cat periaqueductal gray. II. The distribution of immunoreactive substance P and vasoactive intestinal polypeptide. J Neurosci. 1983 Jul; 3(7):1437-49.
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      244. Moss MS, Glazer EJ, Basbaum AI. The peptidergic organization of the cat periaqueductal gray. I. The distribution of immunoreactive enkephalin-containing neurons and terminals. J Neurosci. 1983 Mar; 3(3):603-16.
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      245. Basbaum AI, Glazer EJ. Immunoreactive vasoactive intestinal polypeptide is concentrated in the sacral spinal cord: a possible marker for pelvic visceral afferent fibers. Somatosens Res. 1983; 1(1):69-82.
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      246. Basbaum AI, Glazer EJ, Lord BA. Simultaneous ultrastructural localization of tritiated serotonin and immunoreactive peptides. J Histochem Cytochem. 1982 Aug; 30(8):780-4.
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      247. Grossman ML, Basbaum AI, Fields HL. Afferent and efferent connections of the rat tail flick reflex (a model used to analyze pain control mechanisms). J Comp Neurol. 1982 Mar 20; 206(1):9-16.
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      248. Abols IA, Basbaum AI. Afferent connections of the rostral medulla of the cat: a neural substrate for midbrain-medullary interactions in the modulation of pain. J Comp Neurol. 1981 Sep 10; 201(2):285-97.
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      249. Glazer EJ, Basbaum AI. Immunohistochemical localization of leucine-enkephalin in the spinal cord of the cat: enkephalin-containing marginal neurons and pain modulation. J Comp Neurol. 1981 Mar 1; 196(3):377-89.
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      250. Glazer EJ, Steinbusch H, Verhofstad A, Basbaum AI. Serotonin neurons in nucleus raphe dorsalis and paragigantocellularis of the cat contain enkephalin. J Physiol (Paris). 1981; 77(2-3):241-5.
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      251. Moss MS, Glazer EJ, Basbaum AI. Enkephalin-immunoreactive perikarya in the cat raphe dorsalis. Neurosci Lett. 1981 Jan 1; 21(1):33-7.
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      252. Basbaum AI. Descending control of pain transmission: possible serotonergic-enkephalinergic interactions. Adv Exp Med Biol. 1981; 133:177-89.
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      253. Glazer EJ, Basbaum AI. Leucine enkephalin: localization in and axoplasmic transport by sacral parasympathetic preganglionic neurons. Science. 1980 Jun 27; 208(4451):1479-81.
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      254. Barton C, Basbaum AI, Fields HL. Dissociation of supraspinal and spinal actions of morphine: a quantitative evaluation. Brain Res. 1980 Apr 28; 188(2):487-98.
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      255. Basbaum AI, Fields HL. The origin of descending pathways in the dorsolateral funiculus of the spinal cord of the cat and rat: further studies on the anatomy of pain modulation. J Comp Neurol. 1979 Oct 1; 187(3):513-31.
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      256. Abols IA, Basbaum AI. The posterior pretectal nucleus: evidence for a direct projection to the inferior olive of the cat. Neurosci Lett. 1979 Jul; 13(2):111-6.
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      257. Giesler GJ, Menétrey D, Basbaum AI. Differential origins of spinothalamic tract projections to medial and lateral thalamus in the rat. J Comp Neurol. 1979 Mar 1; 184(1):107-26.
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      258. Wong RK, Prince DA, Basbaum AI. Intradendritic recordings from hippocampal neurons. Proc Natl Acad Sci U S A. 1979 Feb; 76(2):986-90.
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      259. Basbaum AI, Fields HL. Endogenous pain control mechanisms: review and hypothesis. Ann Neurol. 1978 Nov; 4(5):451-62.
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      260. Basbaum AI, Clanton CH, Fields HL. Three bulbospinal pathways from the rostral medulla of the cat: an autoradiographic study of pain modulating systems. J Comp Neurol. 1978 Mar 15; 178(2):209-24.
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      261. Fields HL, Basbaum AI. Brainstem control of spinal pain-transmission neurons. Annu Rev Physiol. 1978; 40:217-48.
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      262. Fields HL, Basbaum AI, Clanton CH, Anderson SD. Nucleus raphe magnus inhibition of spinal cord dorsal horn neurons. Brain Res. 1977 May 13; 126(3):441-53.
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      263. Anderson SD, Basbaum AI, Fields HL. Response of medullary raphe neurons to peripheral stimulation and to systemic opiates. Brain Res. 1977 Mar 11; 123(2):363-8.
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      264. Basbaum AI, Marley NJ, O'Keefe J, Clanton CH. Reversal of morphine and stimulus-produced analgesia by subtotal spinal cord lesions. Pain. 1977 Feb; 3(1):43-56.
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      265. Basbaum AI, Clanton CH, Fields HL. Opiate and stimulus-produced analgesia: functional anatomy of a medullospinal pathway. Proc Natl Acad Sci U S A. 1976 Dec; 73(12):4685-8.
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      266. Basbaum AI, Wall PD. Chronic changes in the response of cells in adult cat dorsal horn following partial deafferentation: the appearance of responding cells in a previously non-responsive region. Brain Res. 1976 Nov 5; 116(2):181-204.
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      267. Millar J, Basbaum AI, Wall PD. Restructuring of the somatotopic map and appearance of abnormal neuronal activity in the gracile nucleus after partial deafferentation. Exp Neurol. 1976 Mar; 50(3):658-72.
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      268. Fields HL, Anderson SD, Clanton CH, Basbaum AI. Nucleus raphe magnus: a common mediator of opiate- and stimulus-produced analgesia. Trans Am Neurol Assoc. 1976; 101:208-10.
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      269. Millar J, Basbaum AI. Topography of the projection of the body surface of the cat to cuneate and gracile nuclei. Exp Neurol. 1975 Oct; 49(1 Pt 1):281-90.
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      270. Wall PD, Waxman S, Basbaum AI. Ongoing activity in peripheral nerve: injury discharge. Exp Neurol. 1974 Dec; 45(3):576-89.
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      271. Basbaum AI. Effects of central lesions on disorders produced by multiple dorsal rhizotomy in rats. Exp Neurol. 1974 Mar; 42(3):490-501.
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      272. Basbaum AI. Conduction of the effects of noxious stimulation by short-fiber multisynaptic systems of the spinal cord in the rat. Exp Neurol. 1973 Sep; 40(3):699-716.
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      273. Basbaum AI, Hand PJ. Projections of cervicothoracic dorsal roots to the cuneate nucleus of the rat, with observations on cellular "bricks". J Comp Neurol. 1973 Apr 1; 148(3):347-59.
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