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    Arthur Weiss, MD, PhD

    TitleProfessor
    SchoolUCSF School of Medicine
    DepartmentMedicine
    Address513 Parnassus Ave, Med Sci
    San Francisco CA 94143
    Phone415-476-1291
      Other Positions
      TitleHoward Hughes Investigator


       Biography 
       Education and Training
      Institution Degree School or Department Year
      University of California, San FranciscoResidency Rheumatology
       Awards and Honors
      UCSF2012Lifetime Achievement in Mentoring Award
      American Association of Immunologists2012Lifetime Achievement Award
      Institute of Medicine2004Member
      American College of Rheumatology2004Distinguished Investigator Award
      National Academy of Sciences2004Member
      American Academy of Arts and Sciences2003Fellow
      American Association of Immunologists2001American Association of Immunologists-Huang Foundation Meritorious Career Award
      UCSF1998Forty-first Faculty Research Lecturer
      Arthritis Foundation1997Lee C. Howley Prize
      American Association of Immunologists1993Junior Investigator Award
      Western Society for Clinical Investigation1990Young Investigator Award
      American College of Rheumatology1990Henry Kunkel Young Investigator Award

       Overview 
       Overview
      Research Interest:

      The response of lymphocytes to antigen which initiates an antigen specific immune response also represents a unique opportunity to study how complex molecular interactions between cells can lead to developmental decisions, cell differentiation and proliferation. We are interested in understanding how receptors involved in antigen recognition can initiate signal transduction events that regulate cell responses in the immune system. We know that receptors involved in antigen recognition functionally interact with tyrosine kinases and phosphatases, enzymes that regulate protein phosphorylation, to induce signaling pathways that regulate cellular responses and gene expression. We are using genetically selective small molecule inhibitors of kinases together with phosphatase mutants to study how thresholds for the initiation of immune responses are set and how feedback circuits influence responses. We would like to understand how the tyrosine kinases and phosphatases in these pathways are regulated and how they control cellular responses in development, in normal immune responses and in autoimmune diseases such as lupus and rheumatoid arthritis.


       ORNG Applications 
       Websites
       In The News
       Awarded Grants
       More Info

       Bibliographic 
       Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Au-Yeung BB, Melichar HJ, Ross JO, Cheng DA, Zikherman J, Shokat KM, Robey EA, Weiss A. Quantitative and temporal requirements revealed for Zap70 catalytic activity during T cell development. Nat Immunol. 2014 Jul; 15(7):687-94.
        View in: PubMed
      2. Wang H, Flach H, Onizawa M, Wei L, McManus MT, Weiss A. Negative regulation of Hif1a expression and TH17 differentiation by the hypoxia-regulated microRNA miR-210. Nat Immunol. 2014 Apr; 15(4):393-401.
        View in: PubMed
      3. Limnander A, Zikherman J, Lau T, Leitges M, Weiss A, Roose JP. Protein kinase cd promotes transitional B cell-negative selection and limits proximal B cell receptor signaling to enforce tolerance. Mol Cell Biol. 2014 Apr; 34(8):1474-85.
        View in: PubMed
      4. Tan YX, Manz BN, Freedman TS, Zhang C, Shokat KM, Weiss A. Inhibition of the kinase Csk in thymocytes reveals a requirement for actin remodeling in the initiation of full TCR signaling. Nat Immunol. 2014 Feb; 15(2):186-94.
        View in: PubMed
      5. Weiss A. Tony Pawson: Modular protein domains and the links to intracellular signaling. Proc Natl Acad Sci U S A. 2013 Oct 29; 110(44):17604-5.
        View in: PubMed
      6. Tan YX, Zikherman J, Weiss A. Novel Tools to Dissect the Dynamic Regulation of TCR Signaling by the Kinase Csk and the Phosphatase CD45. Cold Spring Harb Symp Quant Biol. 2013 Oct 7.
        View in: PubMed
      7. Gardner JM, Metzger TC, McMahon EJ, Au-Yeung BB, Krawisz AK, Lu W, Price JD, Johannes KP, Satpathy AT, Murphy KM, Tarbell KV, Weiss A, Anderson MS. Extrathymic Aire-expressing cells are a distinct bone marrow-derived population that induce functional inactivation of CD4? T cells. Immunity. 2013 Sep 19; 39(3):560-72.
        View in: PubMed
      8. Xie M, Hong C, Zhang B, Lowdon RF, Xing X, Li D, Zhou X, Lee HJ, Maire CL, Ligon KL, Gascard P, Sigaroudinia M, Tlsty TD, Kadlecek T, Weiss A, O'Geen H, Farnham PJ, Madden PA, Mungall AJ, Tam A, Kamoh B, Cho S, Moore R, Hirst M, Marra MA, Costello JF, Wang T. DNA hypomethylation within specific transposable element families associates with tissue-specific enhancer landscape. Nat Genet. 2013 Jul; 45(7):836-41.
        View in: PubMed
      9. Katsumoto TR, Kudo M, Chen C, Sundaram A, Callahan EC, Zhu JW, Lin J, Rosen CE, Manz BN, Lee JW, Matthay MA, Huang X, Sheppard D, Weiss A. The phosphatase CD148 promotes airway hyperresponsiveness through SRC family kinases. J Clin Invest. 2013 May 1; 123(5):2037-48.
        View in: PubMed
      10. Yan Q, Barros T, Visperas PR, Deindl S, Kadlecek TA, Weiss A, Kuriyan J. Structural basis for activation of ZAP-70 by phosphorylation of the SH2-kinase linker. Mol Cell Biol. 2013 Jun; 33(11):2188-201.
        View in: PubMed
      11. Zikherman J, Parameswaran R, Hermiston M, Weiss A. The structural wedge domain of the receptor-like tyrosine phosphatase CD45 enforces B cell tolerance by regulating substrate specificity. J Immunol. 2013 Mar 15; 190(6):2527-35.
        View in: PubMed
      12. Mukherjee S, Zhu J, Zikherman J, Parameswaran R, Kadlecek TA, Wang Q, Au-Yeung B, Ploegh H, Kuriyan J, Das J, Weiss A. Monovalent and multivalent ligation of the B cell receptor exhibit differential dependence upon Syk and Src family kinases. Sci Signal. 2013 Jan 1; 6(256):ra1.
        View in: PubMed
      13. Charles JF, Hsu LY, Niemi EC, Weiss A, Aliprantis AO, Nakamura MC. Inflammatory arthritis increases mouse osteoclast precursors with myeloid suppressor function. J Clin Invest. 2012 Dec 3; 122(12):4592-605.
        View in: PubMed
      14. Zikherman J, Parameswaran R, Weiss A. Endogenous antigen tunes the responsiveness of naive B cells but not T cells. Nature. 2012 Sep 6; 489(7414):160-4.
        View in: PubMed
      15. Wei P, Wong WW, Park JS, Corcoran EE, Peisajovich SG, Onuffer JJ, Weiss A, Lim WA. Bacterial virulence proteins as tools to rewire kinase pathways in yeast and immune cells. Nature. 2012 Aug 16; 488(7411):384-8.
        View in: PubMed
      16. Park CY, Jeker LT, Carver-Moore K, Oh A, Liu HJ, Cameron R, Richards H, Li Z, Adler D, Yoshinaga Y, Martinez M, Nefadov M, Abbas AK, Weiss A, Lanier LL, de Jong PJ, Bluestone JA, Srivastava D, McManus MT. A resource for the conditional ablation of microRNAs in the mouse. Cell Rep. 2012 Apr 19; 1(4):385-91.
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      17. Abel SM, Roose JP, Groves JT, Weiss A, Chakraborty AK. The membrane environment can promote or suppress bistability in cell signaling networks. J Phys Chem B. 2012 Mar 22; 116(11):3630-40.
        View in: PubMed
      18. Baldari CT, Acuto O, Batista F, Koretzky G, Weiss A. Lymphocyte signaling: a Tuscan affair. Nat Immunol. 2012 Jan; 13(1):3-6.
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      19. Zikherman J, Doan K, Parameswaran R, Raschke W, Weiss A. Quantitative differences in CD45 expression unmask functions for CD45 in B-cell development, tolerance, and survival. Proc Natl Acad Sci U S A. 2012 Jan 3; 109(1):E3-12.
        View in: PubMed
      20. Zikherman J, Weiss A. Unraveling the functional implications of GWAS: how T cell protein tyrosine phosphatase drives autoimmune disease. J Clin Invest. 2011 Dec; 121(12):4618-21.
        View in: PubMed
      21. Zhu JW, Doan K, Park J, Chau AH, Zhang H, Lowell CA, Weiss A. Receptor-like tyrosine phosphatases CD45 and CD148 have distinct functions in chemoattractant-mediated neutrophil migration and response to S. aureus. Immunity. 2011 Nov 23; 35(5):757-69.
        View in: PubMed
      22. Markegard E, Trager E, Yang CW, Zhang W, Weiss A, Roose JP. Basal LAT-diacylglycerol-RasGRP1 signals in T cells maintain TCRa gene expression. PLoS One. 2011; 6(9):e25540.
        View in: PubMed
      23. Schoenborn JR, Tan YX, Zhang C, Shokat KM, Weiss A. Feedback circuits monitor and adjust basal Lck-dependent events in T cell receptor signaling. Sci Signal. 2011 Sep 13; 4(190):ra59.
        View in: PubMed
      24. Limnander A, Weiss A. Ca-dependent Ras/Erk signaling mediates negative selection of autoreactive B cells. Small GTPases. 2011 9; 2(5):282-288.
        View in: PubMed
      25. Goodridge HS, Reyes CN, Becker CA, Katsumoto TR, Ma J, Wolf AJ, Bose N, Chan AS, Magee AS, Danielson ME, Weiss A, Vasilakos JP, Underhill DM. Activation of the innate immune receptor Dectin-1 upon formation of a 'phagocytic synapse'. Nature. 2011 Apr 28; 472(7344):471-5.
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      26. Limnander A, Depeille P, Freedman TS, Liou J, Leitges M, Kurosaki T, Roose JP, Weiss A. STIM1, PKC-d and RasGRP set a threshold for proapoptotic Erk signaling during B cell development. Nat Immunol. 2011 May; 12(5):425-33.
        View in: PubMed
      27. Hesslein DG, Palacios EH, Sun JC, Beilke JN, Watson SR, Weiss A, Lanier LL. Differential requirements for CD45 in NK-cell function reveal distinct roles for Syk-family kinases. Blood. 2011 Mar 17; 117(11):3087-95.
        View in: PubMed
      28. Liontos LM, Dissanayake D, Ohashi PS, Weiss A, Dragone LL, McGlade CJ. The Src-like adaptor protein regulates GM-CSFR signaling and monocytic dendritic cell maturation. J Immunol. 2011 Feb 15; 186(4):1923-33.
        View in: PubMed
      29. Au-Yeung BB, Levin SE, Zhang C, Hsu LY, Cheng DA, Killeen N, Shokat KM, Weiss A. A genetically selective inhibitor demonstrates a function for the kinase Zap70 in regulatory T cells independent of its catalytic activity. Nat Immunol. 2010 Dec; 11(12):1085-92.
        View in: PubMed
      30. Beinke S, Phee H, Clingan JM, Schlessinger J, Matloubian M, Weiss A. Proline-rich tyrosine kinase-2 is critical for CD8 T-cell short-lived effector fate. Proc Natl Acad Sci U S A. 2010 Sep 14; 107(37):16234-9.
        View in: PubMed
      31. Phee H, Dzhagalov I, Mollenauer M, Wang Y, Irvine DJ, Robey E, Weiss A. Regulation of thymocyte positive selection and motility by GIT2. Nat Immunol. 2010 Jun; 11(6):503-11.
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      32. Wang H, Kadlecek TA, Au-Yeung BB, Goodfellow HE, Hsu LY, Freedman TS, Weiss A. ZAP-70: an essential kinase in T-cell signaling. Cold Spring Harb Perspect Biol. 2010 May; 2(5):a002279.
        View in: PubMed
      33. Zikherman J, Jenne C, Watson S, Doan K, Raschke W, Goodnow CC, Weiss A. CD45-Csk phosphatase-kinase titration uncouples basal and inducible T cell receptor signaling during thymic development. Immunity. 2010 Mar 26; 32(3):342-54.
        View in: PubMed
      34. Weiss A. The right team at the right time to go for a home run: tyrosine kinase activation by the TCR. Nat Immunol. 2010 Feb; 11(2):101-4.
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      35. Deindl S, Kadlecek TA, Cao X, Kuriyan J, Weiss A. Stability of an autoinhibitory interface in the structure of the tyrosine kinase ZAP-70 impacts T cell receptor response. Proc Natl Acad Sci U S A. 2009 Dec 8; 106(49):20699-704.
        View in: PubMed
      36. Dragone LL, Shaw LA, Myers MD, Weiss A. SLAP, a regulator of immunoreceptor ubiquitination, signaling, and trafficking. Immunol Rev. 2009 Nov; 232(1):218-28.
        View in: PubMed
      37. Hsu LY, Tan YX, Xiao Z, Malissen M, Weiss A. A hypomorphic allele of ZAP-70 reveals a distinct thymic threshold for autoimmune disease versus autoimmune reactivity. J Exp Med. 2009 Oct 26; 206(11):2527-41.
        View in: PubMed
      38. Weiss A. TCR signal transduction: opening the black box. J Immunol. 2009 Oct 15; 183(8):4821-7.
        View in: PubMed
      39. Chakraborty AK, Das J, Zikherman J, Yang M, Govern CC, Ho M, Weiss A, Roose J. Molecular origin and functional consequences of digital signaling and hysteresis during Ras activation in lymphocytes. Sci Signal. 2009; 2(66):pt2.
        View in: PubMed
      40. Zikherman J, Hermiston M, Steiner D, Hasegawa K, Chan A, Weiss A. PTPN22 deficiency cooperates with the CD45 E613R allele to break tolerance on a non-autoimmune background. J Immunol. 2009 Apr 1; 182(7):4093-106.
        View in: PubMed
      41. Au-Yeung BB, Deindl S, Hsu LY, Palacios EH, Levin SE, Kuriyan J, Weiss A. The structure, regulation, and function of ZAP-70. Immunol Rev. 2009 Mar; 228(1):41-57.
        View in: PubMed
      42. Zikherman J, Weiss A. Antigen receptor signaling in the rheumatic diseases. Arthritis Res Ther. 2009; 11(1):202.
        View in: PubMed
      43. Das J, Ho M, Zikherman J, Govern C, Yang M, Weiss A, Chakraborty AK, Roose JP. Digital signaling and hysteresis characterize ras activation in lymphoid cells. Cell. 2009 Jan 23; 136(2):337-51.
        View in: PubMed
      44. Hermiston ML, Zikherman J, Tan AL, Lam VC, Cresalia NM, Oksenberg N, Goren N, Brassat D, Oksenberg JR, Weiss A. Differential impact of the CD45 juxtamembrane wedge on central and peripheral T cell receptor responses. Proc Natl Acad Sci U S A. 2009 Jan 13; 106(2):546-51.
        View in: PubMed
      45. Zikherman J, Weiss A. Alternative splicing of CD45: the tip of the iceberg. Immunity. 2008 Dec 19; 29(6):839-41.
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      46. Prasad A, Zikherman J, Das J, Roose JP, Weiss A, Chakraborty AK. Origin of the sharp boundary that discriminates positive and negative selection of thymocytes. Proc Natl Acad Sci U S A. 2009 Jan 13; 106(2):528-33.
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      47. Louvet C, Szot GL, Lang J, Lee MR, Martinier N, Bollag G, Zhu S, Weiss A, Bluestone JA. Tyrosine kinase inhibitors reverse type 1 diabetes in nonobese diabetic mice. Proc Natl Acad Sci U S A. 2008 Dec 2; 105(48):18895-900.
        View in: PubMed
      48. Gupta VA, Hermiston ML, Cassafer G, Daikh DI, Weiss A. B cells drive lymphocyte activation and expansion in mice with the CD45 wedge mutation and Fas deficiency. J Exp Med. 2008 Nov 24; 205(12):2755-61.
        View in: PubMed
      49. Mingueneau M, Sansoni A, Grégoire C, Roncagalli R, Aguado E, Weiss A, Malissen M, Malissen B. The proline-rich sequence of CD3epsilon controls T cell antigen receptor expression on and signaling potency in preselection CD4+CD8+ thymocytes. Nat Immunol. 2008 May; 9(5):522-32.
        View in: PubMed
      50. Levin SE, Zhang C, Kadlecek TA, Shokat KM, Weiss A. Inhibition of ZAP-70 kinase activity via an analog-sensitive allele blocks T cell receptor and CD28 superagonist signaling. J Biol Chem. 2008 May 30; 283(22):15419-30.
        View in: PubMed
      51. Zhu JW, Brdicka T, Katsumoto TR, Lin J, Weiss A. Structurally distinct phosphatases CD45 and CD148 both regulate B cell and macrophage immunoreceptor signaling. Immunity. 2008 Feb; 28(2):183-96.
        View in: PubMed
      52. Palacios EH, Weiss A. Distinct roles for Syk and ZAP-70 during early thymocyte development. J Exp Med. 2007 Jul 9; 204(7):1703-15.
        View in: PubMed
      53. Deindl S, Kadlecek TA, Brdicka T, Cao X, Weiss A, Kuriyan J. Structural basis for the inhibition of tyrosine kinase activity of ZAP-70. Cell. 2007 May 18; 129(4):735-46.
        View in: PubMed
      54. Chung SC, Limnander A, Kurosaki T, Weiss A, Korenbrot JI. Coupling Ca2+ store release to Icrac channel activation in B lymphocytes requires the activity of Lyn and Syk kinases. J Cell Biol. 2007 Apr 23; 177(2):317-28.
        View in: PubMed
      55. Roose JP, Mollenauer M, Ho M, Kurosaki T, Weiss A. Unusual interplay of two types of Ras activators, RasGRP and SOS, establishes sensitive and robust Ras activation in lymphocytes. Mol Cell Biol. 2007 Apr; 27(7):2732-45.
        View in: PubMed
      56. Balachandran P, Dragone L, Garrity-Ryan L, Lemus A, Weiss A, Engel J. The ubiquitin ligase Cbl-b limits Pseudomonas aeruginosa exotoxin T-mediated virulence. J Clin Invest. 2007 Feb; 117(2):419-27.
        View in: PubMed
      57. Dragone LL, Myers MD, White C, Gadwal S, Sosinowski T, Gu H, Weiss A. Src-like adaptor protein (SLAP) regulates B cell receptor levels in a c-Cbl-dependent manner. Proc Natl Acad Sci U S A. 2006 Nov 28; 103(48):18202-7.
        View in: PubMed
      58. Nirula A, Ho M, Phee H, Roose J, Weiss A. Phosphoinositide-dependent kinase 1 targets protein kinase A in a pathway that regulates interleukin 4. J Exp Med. 2006 Jul 10; 203(7):1733-44.
        View in: PubMed
      59. Hesslein DG, Takaki R, Hermiston ML, Weiss A, Lanier LL. Dysregulation of signaling pathways in CD45-deficient NK cells leads to differentially regulated cytotoxicity and cytokine production. Proc Natl Acad Sci U S A. 2006 May 2; 103(18):7012-7.
        View in: PubMed
      60. Dragone LL, Myers MD, White C, Sosinowski T, Weiss A. SRC-like adaptor protein regulates B cell development and function. J Immunol. 2006 Jan 1; 176(1):335-45.
        View in: PubMed
      61. Myers MD, Sosinowski T, Dragone LL, White C, Band H, Gu H, Weiss A. Src-like adaptor protein regulates TCR expression on thymocytes by linking the ubiquitin ligase c-Cbl to the TCR complex. Nat Immunol. 2006 Jan; 7(1):57-66.
        View in: PubMed
      62. Hermiston ML, Tan AL, Gupta VA, Majeti R, Weiss A. The juxtamembrane wedge negatively regulates CD45 function in B cells. Immunity. 2005 Dec; 23(6):635-47.
        View in: PubMed
      63. Weiss A. Discovering the TCR beta-chain by subtraction. J Immunol. 2005 Sep 1; 175(5):2769-70.
        View in: PubMed
      64. Myers MD, Dragone LL, Weiss A. Src-like adaptor protein down-regulates T cell receptor (TCR)-CD3 expression by targeting TCRzeta for degradation. J Cell Biol. 2005 Jul 18; 170(2):285-94.
        View in: PubMed
      65. Roose JP, Mollenauer M, Gupta VA, Stone J, Weiss A. A diacylglycerol-protein kinase C-RasGRP1 pathway directs Ras activation upon antigen receptor stimulation of T cells. Mol Cell Biol. 2005 Jun; 25(11):4426-41.
        View in: PubMed
      66. Brdicka T, Kadlecek TA, Roose JP, Pastuszak AW, Weiss A. Intramolecular regulatory switch in ZAP-70: analogy with receptor tyrosine kinases. Mol Cell Biol. 2005 Jun; 25(12):4924-33.
        View in: PubMed
      67. Phee H, Abraham RT, Weiss A. Dynamic recruitment of PAK1 to the immunological synapse is mediated by PIX independently of SLP-76 and Vav1. Nat Immunol. 2005 Jun; 6(6):608-17.
        View in: PubMed
      68. Levin SE, Weiss A. Twisting tails exposed: the evidence for TCR conformational change. J Exp Med. 2005 Feb 21; 201(4):489-92.
        View in: PubMed
      69. Tomlinson MG, Heath VL, Turck CW, Watson SP, Weiss A. SHIP family inositol phosphatases interact with and negatively regulate the Tec tyrosine kinase. J Biol Chem. 2004 Dec 31; 279(53):55089-96.
        View in: PubMed
      70. Palacios EH, Weiss A. Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation. Oncogene. 2004 Oct 18; 23(48):7990-8000.
        View in: PubMed
      71. Lin J, Zhu JW, Baker JE, Weiss A. Regulated expression of the receptor-like tyrosine phosphatase CD148 on hemopoietic cells. J Immunol. 2004 Aug 15; 173(4):2324-30.
        View in: PubMed
      72. Kane LP, Mollenauer MN, Weiss A. A proline-rich motif in the C terminus of Akt contributes to its localization in the immunological synapse. J Immunol. 2004 May 1; 172(9):5441-9.
        View in: PubMed
      73. Crotzer VL, Mabardy AS, Weiss A, Brodsky FM. T cell receptor engagement leads to phosphorylation of clathrin heavy chain during receptor internalization. J Exp Med. 2004 Apr 5; 199(7):981-91.
        View in: PubMed
      74. Andres PG, Howland KC, Nirula A, Kane LP, Barron L, Dresnek D, Sadra A, Imboden J, Weiss A, Abbas AK. Distinct regions in the CD28 cytoplasmic domain are required for T helper type 2 differentiation. Nat Immunol. 2004 Apr; 5(4):435-42.
        View in: PubMed
      75. Tomlinson MG, Kane LP, Su J, Kadlecek TA, Mollenauer MN, Weiss A. Expression and function of Tec, Itk, and Btk in lymphocytes: evidence for a unique role for Tec. Mol Cell Biol. 2004 Mar; 24(6):2455-66.
        View in: PubMed
      76. Roose JP, Diehn M, Tomlinson MG, Lin J, Alizadeh AA, Botstein D, Brown PO, Weiss A. T cell receptor-independent basal signaling via Erk and Abl kinases suppresses RAG gene expression. PLoS Biol. 2003 Nov; 1(2):E53.
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      77. Lin J, Weiss A. The tyrosine phosphatase CD148 is excluded from the immunologic synapse and down-regulates prolonged T cell signaling. J Cell Biol. 2003 Aug 18; 162(4):673-82.
        View in: PubMed
      78. Kuhné MR, Lin J, Yablonski D, Mollenauer MN, Ehrlich LI, Huppa J, Davis MM, Weiss A. Linker for activation of T cells, zeta-associated protein-70, and Src homology 2 domain-containing leukocyte protein-76 are required for TCR-induced microtubule-organizing center polarization. J Immunol. 2003 Jul 15; 171(2):860-6.
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      79. Kane LP, Weiss A. The PI-3 kinase/Akt pathway and T cell activation: pleiotropic pathways downstream of PIP3. Immunol Rev. 2003 Apr; 192:7-20.
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      80. Ehrlich LI, Ebert PJ, Krummel MF, Weiss A, Davis MM. Dynamics of p56lck translocation to the T cell immunological synapse following agonist and antagonist stimulation. Immunity. 2002 Dec; 17(6):809-22.
        View in: PubMed
      81. Kane LP, Mollenauer MN, Xu Z, Turck CW, Weiss A. Akt-dependent phosphorylation specifically regulates Cot induction of NF-kappa B-dependent transcription. Mol Cell Biol. 2002 Aug; 22(16):5962-74.
        View in: PubMed
      82. Kane LP, Lin J, Weiss A. It's all Rel-ative: NF-kappaB and CD28 costimulation of T-cell activation. Trends Immunol. 2002 Aug; 23(8):413-20.
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      83. Xu Z, Weiss A. Negative regulation of CD45 by differential homodimerization of the alternatively spliced isoforms. Nat Immunol. 2002 Aug; 3(8):764-71.
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      84. Xu Z, Stokoe D, Kane LP, Weiss A. The inducible expression of the tumor suppressor gene PTEN promotes apoptosis and decreases cell size by inhibiting the PI3K/Akt pathway in Jurkat T cells. Cell Growth Differ. 2002 Jul; 13(7):285-96.
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      85. Hermiston ML, Xu Z, Majeti R, Weiss A. Reciprocal regulation of lymphocyte activation by tyrosine kinases and phosphatases. J Clin Invest. 2002 Jan; 109(1):9-14.
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      86. Hermiston ML, Xu Z, Weiss A. CD45: a critical regulator of signaling thresholds in immune cells. Annu Rev Immunol. 2003; 21:107-37.
        View in: PubMed
      87. Barcellos LF, Caillier S, Dragone L, Elder M, Vittinghoff E, Bucher P, Lincoln RR, Pericak-Vance M, Haines JL, Weiss A, Hauser SL, Oksenberg JR. PTPRC (CD45) is not associated with the development of multiple sclerosis in U.S. patients. Nat Genet. 2001 Sep; 29(1):23-4.
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      88. Sosinowski T, Killeen N, Weiss A. The Src-like adaptor protein downregulates the T cell receptor on CD4+CD8+ thymocytes and regulates positive selection. Immunity. 2001 Sep; 15(3):457-66.
        View in: PubMed
      89. Sauer K, Liou J, Singh SB, Yablonski D, Weiss A, Perlmutter RM. Hematopoietic progenitor kinase 1 associates physically and functionally with the adaptor proteins B cell linker protein and SLP-76 in lymphocytes. J Biol Chem. 2001 Nov 30; 276(48):45207-16.
        View in: PubMed
      90. Majeti R, Weiss A. Regulatory mechanisms for receptor protein tyrosine phosphatases. Chem Rev. 2001 Aug; 101(8):2441-8.
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      91. Yablonski D, Kadlecek T, Weiss A. Identification of a phospholipase C-gamma1 (PLC-gamma1) SH3 domain-binding site in SLP-76 required for T-cell receptor-mediated activation of PLC-gamma1 and NFAT. Mol Cell Biol. 2001 Jul; 21(13):4208-18.
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      92. Shapiro VS, Mollenauer MN, Weiss A. Endogenous CD28 expressed on myeloma cells up-regulates interleukin-8 production: implications for multiple myeloma progression. Blood. 2001 Jul 1; 98(1):187-93.
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      93. Lin J, Weiss A. Identification of the minimal tyrosine residues required for linker for activation of T cell function. J Biol Chem. 2001 Aug 3; 276(31):29588-95.
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      94. Lynch KW, Weiss A. A CD45 polymorphism associated with multiple sclerosis disrupts an exonic splicing silencer. J Biol Chem. 2001 Jun 29; 276(26):24341-7.
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      95. Baker JE, Majeti R, Tangye SG, Weiss A. Protein tyrosine phosphatase CD148-mediated inhibition of T-cell receptor signal transduction is associated with reduced LAT and phospholipase Cgamma1 phosphorylation. Mol Cell Biol. 2001 Apr; 21(7):2393-403.
        View in: PubMed
      96. Ku GM, Yablonski D, Manser E, Lim L, Weiss A. A PAK1-PIX-PKL complex is activated by the T-cell receptor independent of Nck, Slp-76 and LAT. EMBO J. 2001 Feb 1; 20(3):457-65.
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      97. Kratchmarova I, Sosinowski T, Weiss A, Witter K, Vincenz C, Pandey A. Characterization of promoter region and genomic structure of the murine and human genes encoding Src like adapter protein. Gene. 2001 Jan 10; 262(1-2):267-73.
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      98. Yablonski D, Weiss A. Mechanisms of signaling by the hematopoietic-specific adaptor proteins, SLP-76 and LAT and their B cell counterpart, BLNK/SLP-65. Adv Immunol. 2001; 79:93-128.
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      99. Kane LP, Andres PG, Howland KC, Abbas AK, Weiss A. Akt provides the CD28 costimulatory signal for up-regulation of IL-2 and IFN-gamma but not TH2 cytokines. Nat Immunol. 2001 Jan; 2(1):37-44.
        View in: PubMed
      100. Elder ME, Skoda-Smith S, Kadlecek TA, Wang F, Wu J, Weiss A. Distinct T cell developmental consequences in humans and mice expressing identical mutations in the DLAARN motif of ZAP-70. J Immunol. 2001 Jan 1; 166(1):656-61.
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      101. Lin J, Weiss A. T cell receptor signalling. J Cell Sci. 2001 Jan; 114(Pt 2):243-4.
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      102. Majeti R, Xu Z, Parslow TG, Olson JL, Daikh DI, Killeen N, Weiss A. An inactivating point mutation in the inhibitory wedge of CD45 causes lymphoproliferation and autoimmunity. Cell. 2000 Dec 22; 103(7):1059-70.
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      103. Tomlinson MG, Lin J, Weiss A. Lymphocytes with a complex: adapter proteins in antigen receptor signaling. Immunol Today. 2000 Nov; 21(11):584-91.
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      104. Kane LP, Lin J, Weiss A. Signal transduction by the TCR for antigen. Curr Opin Immunol. 2000 Jun; 12(3):242-9.
        View in: PubMed
      105. Liou J, Kiefer F, Dang A, Hashimoto A, Cobb MH, Kurosaki T, Weiss A. HPK1 is activated by lymphocyte antigen receptors and negatively regulates AP-1. Immunity. 2000 Apr; 12(4):399-408.
        View in: PubMed
      106. Sosinowski T, Pandey A, Dixit VM, Weiss A. Src-like adaptor protein (SLAP) is a negative regulator of T cell receptor signaling. J Exp Med. 2000 Feb 7; 191(3):463-74.
        View in: PubMed
      107. Kuhne MR, Ku G, Weiss A. A guanine nucleotide exchange factor-independent function of Vav1 in transcriptional activation. J Biol Chem. 2000 Jan 21; 275(3):2185-90.
        View in: PubMed
      108. Witherden D, van Oers N, Waltzinger C, Weiss A, Benoist C, Mathis D. Tetracycline-controllable selection of CD4(+) T cells: half-life and survival signals in the absence of major histocompatibility complex class II molecules. J Exp Med. 2000 Jan 17; 191(2):355-64.
        View in: PubMed
      109. Lynch KW, Weiss A. A model system for activation-induced alternative splicing of CD45 pre-mRNA in T cells implicates protein kinase C and Ras. Mol Cell Biol. 2000 Jan; 20(1):70-80.
        View in: PubMed
      110. Lin J, Weiss A, Finco TS. Localization of LAT in glycolipid-enriched microdomains is required for T cell activation. J Biol Chem. 1999 Oct 8; 274(41):28861-4.
        View in: PubMed
      111. Chu DH, van Oers NS, Malissen M, Harris J, Elder M, Weiss A. Pre-T cell receptor signals are responsible for the down-regulation of Syk protein tyrosine kinase expression. J Immunol. 1999 Sep 1; 163(5):2610-20.
        View in: PubMed
      112. Lagunoff M, Majeti R, Weiss A, Ganem D. Deregulated signal transduction by the K1 gene product of Kaposi's sarcoma-associated herpesvirus. Proc Natl Acad Sci U S A. 1999 May 11; 96(10):5704-9.
        View in: PubMed
      113. Zhao Q, Williams BL, Abraham RT, Weiss A. Interdomain B in ZAP-70 regulates but is not required for ZAP-70 signaling function in lymphocytes. Mol Cell Biol. 1999 Jan; 19(1):948-56.
        View in: PubMed
      114. Finco TS, Yablonski D, Lin J, Weiss A. The adapter proteins LAT and SLP-76 are required for T-cell activation. Cold Spring Harb Symp Quant Biol. 1999; 64:265-74.
        View in: PubMed
      115. Shapiro VS, Mollenauer MN, Weiss A. Nuclear factor of activated T cells and AP-1 are insufficient for IL-2 promoter activation: requirement for CD28 up-regulation of RE/AP. J Immunol. 1998 Dec 15; 161(12):6455-8.
        View in: PubMed
      116. Finco TS, Kadlecek T, Zhang W, Samelson LE, Weiss A. LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway. Immunity. 1998 Nov; 9(5):617-26.
        View in: PubMed
      117. Kadlecek TA, van Oers NS, Lefrancois L, Olson S, Finlay D, Chu DH, Connolly K, Killeen N, Weiss A. Differential requirements for ZAP-70 in TCR signaling and T cell development. J Immunol. 1998 Nov 1; 161(9):4688-94.
        View in: PubMed
      118. Yablonski D, Kane LP, Qian D, Weiss A. A Nck-Pak1 signaling module is required for T-cell receptor-mediated activation of NFAT, but not of JNK. EMBO J. 1998 Oct 1; 17(19):5647-57.
        View in: PubMed
      119. Weiss A, Schlessinger J. Switching signals on or off by receptor dimerization. Cell. 1998 Aug 7; 94(3):277-80.
        View in: PubMed
      120. Yablonski D, Kuhne MR, Kadlecek T, Weiss A. Uncoupling of nonreceptor tyrosine kinases from PLC-gamma1 in an SLP-76-deficient T cell. Science. 1998 Jul 17; 281(5375):413-6.
        View in: PubMed
      121. Grazioli L, Germain V, Weiss A, Acuto O. Anti-peptide antibodies detect conformational changes of the inter-SH2 domain of ZAP-70 due to binding to the zeta chain and to intramolecular interactions. J Biol Chem. 1998 Apr 10; 273(15):8916-21.
        View in: PubMed
      122. van Oers NS, Love PE, Shores EW, Weiss A. Regulation of TCR signal transduction in murine thymocytes by multiple TCR zeta-chain signaling motifs. J Immunol. 1998 Jan 1; 160(1):163-70.
        View in: PubMed
      123. Liao XC, Littman DR, Weiss A. Itk and Fyn make independent contributions to T cell activation. J Exp Med. 1997 Dec 15; 186(12):2069-73.
        View in: PubMed
      124. Liao XC, Fournier S, Killeen N, Weiss A, Allison JP, Littman DR. Itk negatively regulates induction of T cell proliferation by CD28 costimulation. J Exp Med. 1997 Jul 21; 186(2):221-8.
        View in: PubMed
      125. Shapiro VS, Truitt KE, Imboden JB, Weiss A. CD28 mediates transcriptional upregulation of the interleukin-2 (IL-2) promoter through a composite element containing the CD28RE and NF-IL-2B AP-1 sites. Mol Cell Biol. 1997 Jul; 17(7):4051-8.
        View in: PubMed
      126. Huby RD, Iwashima M, Weiss A, Ley SC. ZAP-70 protein tyrosine kinase is constitutively targeted to the T cell cortex independently of its SH2 domains. J Cell Biol. 1997 Jun 30; 137(7):1639-49.
        View in: PubMed
      127. Wu J, Zhao Q, Kurosaki T, Weiss A. The Vav binding site (Y315) in ZAP-70 is critical for antigen receptor-mediated signal transduction. J Exp Med. 1997 May 19; 185(10):1877-82.
        View in: PubMed
      128. Qian D, Lev S, van Oers NS, Dikic I, Schlessinger J, Weiss A. Tyrosine phosphorylation of Pyk2 is selectively regulated by Fyn during TCR signaling. J Exp Med. 1997 Apr 7; 185(7):1253-9.
        View in: PubMed
      129. Qian D, Weiss A. T cell antigen receptor signal transduction. Curr Opin Cell Biol. 1997 Apr; 9(2):205-12.
        View in: PubMed
      130. Chu DH, Spits H, Peyron JF, Rowley RB, Bolen JB, Weiss A. The Syk protein tyrosine kinase can function independently of CD45 or Lck in T cell antigen receptor signaling. EMBO J. 1996 Nov 15; 15(22):6251-61.
        View in: PubMed
      131. van Oers NS, Lowin-Kropf B, Finlay D, Connolly K, Weiss A. alpha beta T cell development is abolished in mice lacking both Lck and Fyn protein tyrosine kinases. Immunity. 1996 Nov; 5(5):429-36.
        View in: PubMed
      132. Shapiro VS, Mollenauer MN, Greene WC, Weiss A. c-rel regulation of IL-2 gene expression may be mediated through activation of AP-1. J Exp Med. 1996 Nov 1; 184(5):1663-9.
        View in: PubMed
      133. Taylor N, Bacon KB, Smith S, Jahn T, Kadlecek TA, Uribe L, Kohn DB, Gelfand EW, Weiss A, Weinberg K. Reconstitution of T cell receptor signaling in ZAP-70-deficient cells by retroviral transduction of the ZAP-70 gene. J Exp Med. 1996 Nov 1; 184(5):2031-6.
        View in: PubMed
      134. Fry AM, Lanier LL, Weiss A. Phosphotyrosines in the killer cell inhibitory receptor motif of NKB1 are required for negative signaling and for association with protein tyrosine phosphatase 1C. J Exp Med. 1996 Jul 1; 184(1):295-300.
        View in: PubMed
      135. Wu J, Motto DG, Koretzky GA, Weiss A. Vav and SLP-76 interact and functionally cooperate in IL-2 gene activation. Immunity. 1996 Jun; 4(6):593-602.
        View in: PubMed
      136. Straus DB, Chan AC, Patai B, Weiss A. SH2 domain function is essential for the role of the Lck tyrosine kinase in T cell receptor signal transduction. J Biol Chem. 1996 Apr 26; 271(17):9976-81.
        View in: PubMed
      137. van Oers NS, Killeen N, Weiss A. Lck regulates the tyrosine phosphorylation of the T cell receptor subunits and ZAP-70 in murine thymocytes. J Exp Med. 1996 Mar 1; 183(3):1053-62.
        View in: PubMed
      138. Qian D, Mollenauer MN, Weiss A. Dominant-negative zeta-associated protein 70 inhibits T cell antigen receptor signaling. J Exp Med. 1996 Feb 1; 183(2):611-20.
        View in: PubMed
      139. Crooks ME, Littman DR, Carter RH, Fearon DT, Weiss A, Stein PH. CD28-mediated costimulation in the absence of phosphatidylinositol 3-kinase association and activation. Mol Cell Biol. 1995 Dec; 15(12):6820-8.
        View in: PubMed
      140. Gelfand EW, Weinberg K, Mazer BD, Kadlecek TA, Weiss A. Absence of ZAP-70 prevents signaling through the antigen receptor on peripheral blood T cells but not on thymocytes. J Exp Med. 1995 Oct 1; 182(4):1057-65.
        View in: PubMed
      141. Weiss A, Kadlecek T, Iwashima M, Chan A, Van Oers N. Molecular and genetic insights into T-cell antigen receptor signaling. Ann N Y Acad Sci. 1995 Sep 7; 766:149-56.
        View in: PubMed
      142. Weiss A. Molecular and genetic insights into the role of protein tyrosine kinases in T cell receptor signaling. Clin Immunol Immunopathol. 1995 Sep; 76(3 Pt 2):S158-62.
        View in: PubMed
      143. Wu J, Katzav S, Weiss A. A functional T-cell receptor signaling pathway is required for p95vav activity. Mol Cell Biol. 1995 Aug; 15(8):4337-46.
        View in: PubMed
      144. Howe LR, Weiss A. Multiple kinases mediate T-cell-receptor signaling. Trends Biochem Sci. 1995 Feb; 20(2):59-64.
        View in: PubMed
      145. Katzav S, Sutherland M, Packham G, Yi T, Weiss A. The protein tyrosine kinase ZAP-70 can associate with the SH2 domain of proto-Vav. J Biol Chem. 1994 Dec 23; 269(51):32579-85.
        View in: PubMed
      146. van Oers NS, Killeen N, Weiss A. ZAP-70 is constitutively associated with tyrosine-phosphorylated TCR zeta in murine thymocytes and lymph node T cells. Immunity. 1994 Nov; 1(8):675-85.
        View in: PubMed
      147. Izquierdo M, Leevers SJ, Williams DH, Marshall CJ, Weiss A, Cantrell D. The role of protein kinase C in the regulation of extracellular signal-regulated kinase by the T cell antigen receptor. Eur J Immunol. 1994 Oct; 24(10):2462-8.
        View in: PubMed
      148. Desai DM, Sap J, Silvennoinen O, Schlessinger J, Weiss A. The catalytic activity of the CD45 membrane-proximal phosphatase domain is required for TCR signaling and regulation. EMBO J. 1994 Sep 1; 13(17):4002-10.
        View in: PubMed
      149. Sieh M, Batzer A, Schlessinger J, Weiss A. GRB2 and phospholipase C-gamma 1 associate with a 36- to 38-kilodalton phosphotyrosine protein after T-cell receptor stimulation. Mol Cell Biol. 1994 Jul; 14(7):4435-42.
        View in: PubMed
      150. Chan AC, Kadlecek TA, Elder ME, Filipovich AH, Kuo WL, Iwashima M, Parslow TG, Weiss A. ZAP-70 deficiency in an autosomal recessive form of severe combined immunodeficiency. Science. 1994 Jun 10; 264(5165):1599-601.
        View in: PubMed
      151. Elder ME, Lin D, Clever J, Chan AC, Hope TJ, Weiss A, Parslow TG. Human severe combined immunodeficiency due to a defect in ZAP-70, a T cell tyrosine kinase. Science. 1994 Jun 10; 264(5165):1596-9.
        View in: PubMed
      152. Chan AC, van Oers NS, Tran A, Turka L, Law CL, Ryan JC, Clark EA, Weiss A. Differential expression of ZAP-70 and Syk protein tyrosine kinases, and the role of this family of protein tyrosine kinases in TCR signaling. J Immunol. 1994 May 15; 152(10):4758-66.
        View in: PubMed
      153. Stein PH, Fraser JD, Weiss A. The cytoplasmic domain of CD28 is both necessary and sufficient for costimulation of interleukin-2 secretion and association with phosphatidylinositol 3'-kinase. Mol Cell Biol. 1994 May; 14(5):3392-402.
        View in: PubMed
      154. Law CL, Sidorenko SP, Chandran KA, Draves KE, Chan AC, Weiss A, Edelhoff S, Disteche CM, Clark EA. Molecular cloning of human Syk. A B cell protein-tyrosine kinase associated with the surface immunoglobulin M-B cell receptor complex. J Biol Chem. 1994 Apr 22; 269(16):12310-9.
        View in: PubMed
      155. van Oers NS, Teh SJ, Irving BA, Tiong J, Weiss A, Teh HS. Production and characterization of monoclonal antibodies specific for the murine T cell receptor zeta chain. J Immunol Methods. 1994 Apr 15; 170(2):261-8.
        View in: PubMed
      156. Iwashima M, Irving BA, van Oers NS, Chan AC, Weiss A. Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases. Science. 1994 Feb 25; 263(5150):1136-9.
        View in: PubMed
      157. Weiss A, Littman DR. Signal transduction by lymphocyte antigen receptors. Cell. 1994 Jan 28; 76(2):263-74.
        View in: PubMed
      158. Weiss A, Iwashima M, Irving B, van Oers NS, Kadlecek TA, Straus D, Chan A. Molecular and genetic insights into T cell antigen receptor signal transduction. Adv Exp Med Biol. 1994; 365:53-62.
        View in: PubMed
      159. Chan AC, Desai DM, Weiss A. The role of protein tyrosine kinases and protein tyrosine phosphatases in T cell antigen receptor signal transduction. Annu Rev Immunol. 1994; 12:555-92.
        View in: PubMed
      160. Fraser JD, Straus D, Weiss A. Signal transduction events leading to T-cell lymphokine gene expression. Immunol Today. 1993 Jul; 14(7):357-62.
        View in: PubMed
      161. Desai DM, Sap J, Schlessinger J, Weiss A. Ligand-mediated negative regulation of a chimeric transmembrane receptor tyrosine phosphatase. Cell. 1993 May 7; 73(3):541-54.
        View in: PubMed
      162. Weiss A. T cell antigen receptor signal transduction: a tale of tails and cytoplasmic protein-tyrosine kinases. Cell. 1993 Apr 23; 73(2):209-12.
        View in: PubMed
      163. Irving BA, Chan AC, Weiss A. Functional characterization of a signal transducing motif present in the T cell antigen receptor zeta chain. J Exp Med. 1993 Apr 1; 177(4):1093-103.
        View in: PubMed
      164. Sieh M, Bolen JB, Weiss A. CD45 specifically modulates binding of Lck to a phosphopeptide encompassing the negative regulatory tyrosine of Lck. EMBO J. 1993 Jan; 12(1):315-21.
        View in: PubMed
      165. Chan AC, Iwashima M, Turck CW, Weiss A. ZAP-70: a 70 kd protein-tyrosine kinase that associates with the TCR zeta chain. Cell. 1992 Nov 13; 71(4):649-62.
        View in: PubMed
      166. Graber M, June CH, Samelson LE, Weiss A. The protein tyrosine kinase inhibitor herbimycin A, but not genistein, specifically inhibits signal transduction by the T cell antigen receptor. Int Immunol. 1992 Nov; 4(11):1201-10.
        View in: PubMed
      167. Fraser JD, Weiss A. Regulation of T-cell lymphokine gene transcription by the accessory molecule CD28. Mol Cell Biol. 1992 Oct; 12(10):4357-63.
        View in: PubMed
      168. Straus DB, Weiss A. Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor. Cell. 1992 Aug 21; 70(4):585-93.
        View in: PubMed
      169. Koretzky GA, Kohmetscher MA, Kadleck T, Weiss A. Restoration of T cell receptor-mediated signal transduction by transfection of CD45 cDNA into a CD45-deficient variant of the Jurkat T cell line. J Immunol. 1992 Aug 15; 149(4):1138-42.
        View in: PubMed
      170. Chan AC, Irving BA, Weiss A. New insights into T-cell antigen receptor structure and signal transduction. Curr Opin Immunol. 1992 Jun; 4(3):246-51.
        View in: PubMed
      171. Fraser JD, Newton ME, Weiss A. CD28 and T cell antigen receptor signal transduction coordinately regulate interleukin 2 gene expression in response to superantigen stimulation. J Exp Med. 1992 Apr 1; 175(4):1131-4.
        View in: PubMed
      172. Margolis B, Hu P, Katzav S, Li W, Oliver JM, Ullrich A, Weiss A, Schlessinger J. Tyrosine phosphorylation of vav proto-oncogene product containing SH2 domain and transcription factor motifs. Nature. 1992 Mar 5; 356(6364):71-4.
        View in: PubMed
      173. Weiss A, Chan AC, Iwashima M, Straus D, Irving BA. Regulation of protein tyrosine kinase activation by the T-cell antigen receptor zeta chain. Cold Spring Harb Symp Quant Biol. 1992; 57:107-16.
        View in: PubMed
      174. Chan AC, Irving BA, Fraser JD, Weiss A. The zeta chain is associated with a tyrosine kinase and upon T-cell antigen receptor stimulation associates with ZAP-70, a 70-kDa tyrosine phosphoprotein. Proc Natl Acad Sci U S A. 1991 Oct 15; 88(20):9166-70.
        View in: PubMed
      175. Weiss A, Irving BA, Tan LK, Koretzky GA. Signal transduction by the T cell antigen receptor. Semin Immunol. 1991 Sep; 3(5):313-24.
        View in: PubMed
      176. Weiss A, Koretzky G, Schatzman RC, Kadlecek T. Functional activation of the T-cell antigen receptor induces tyrosine phosphorylation of phospholipase C-gamma 1. Proc Natl Acad Sci U S A. 1991 Jul 1; 88(13):5484-8.
        View in: PubMed
      177. Graber M, Bockenstedt LK, Weiss A. Signaling via the inositol phospholipid pathway by T cell antigen receptor is limited by receptor number. J Immunol. 1991 May 1; 146(9):2935-43.
        View in: PubMed
      178. Tan L, Turner J, Weiss A. Regions of the T cell receptor alpha and beta chains that are responsible for interactions with CD3. J Exp Med. 1991 May 1; 173(5):1247-56.
        View in: PubMed
      179. Koretzky GA, Picus J, Schultz T, Weiss A. Tyrosine phosphatase CD45 is required for T-cell antigen receptor and CD2-mediated activation of a protein tyrosine kinase and interleukin 2 production. Proc Natl Acad Sci U S A. 1991 Mar 15; 88(6):2037-41.
        View in: PubMed
      180. Weiss A, Desai D, Graber M, Picus J, Koretzky G. The regulation of T-cell antigen receptor signal transduction function. Transplant Proc. 1991 Feb; 23(1 Pt 1):32-3.
        View in: PubMed
      181. Fraser JD, Irving BA, Crabtree GR, Weiss A. Regulation of interleukin-2 gene enhancer activity by the T cell accessory molecule CD28. Science. 1991 Jan 18; 251(4991):313-6.
        View in: PubMed
      182. Weiss A. Molecular and genetic insights into T cell antigen receptor structure and function. Annu Rev Genet. 1991; 25:487-510.
        View in: PubMed
      183. Desai DM, Newton ME, Kadlecek T, Weiss A. Stimulation of the phosphatidylinositol pathway can induce T-cell activation. Nature. 1990 Nov 1; 348(6296):66-9.
        View in: PubMed
      184. Weiss A. Structure and function of the T cell antigen receptor. J Clin Invest. 1990 Oct; 86(4):1015-22.
        View in: PubMed
      185. Koretzky GA, Picus J, Thomas ML, Weiss A. Tyrosine phosphatase CD45 is essential for coupling T-cell antigen receptor to the phosphatidyl inositol pathway. Nature. 1990 Jul 5; 346(6279):66-8.
        View in: PubMed
      186. Krensky AM, Weiss A, Crabtree G, Davis MM, Parham P. T-lymphocyte-antigen interactions in transplant rejection. N Engl J Med. 1990 Feb 22; 322(8):510-7.
        View in: PubMed
      187. Desai DM, Goldsmith MA, Weiss A. A transfected human muscarinic receptor fails to substitute for the T cell antigen receptor complex in CD2-initiated signal transduction. Int Immunol. 1990; 2(7):615-20.
        View in: PubMed
      188. Goldsmith MA, Desai DM, Schultz T, Weiss A. Function of a heterologous muscarinic receptor in T cell antigen receptor signal transduction mutants. J Biol Chem. 1989 Oct 15; 264(29):17190-7.
        View in: PubMed
      189. Fraser JD, Goldsmith MA, Weiss A. Ligand-induced association between the T-cell antigen receptor and two glycoproteins. Proc Natl Acad Sci U S A. 1989 Sep; 86(18):7133-7.
        View in: PubMed
      190. Koretzky GA, Wahi M, Newton ME, Weiss A. Heterogeneity of protein kinase C isoenzyme gene expression in human T cell lines. Protein kinase C-beta is not required for several T cell functions. J Immunol. 1989 Sep 1; 143(5):1692-5.
        View in: PubMed
      191. Goldsmith MA, Bockenstedt LK, Dazin P, Weiss A. Use of somatic cell mutants to study the signal transduction function of the T cell antigen receptor. Adv Exp Med Biol. 1989; 254:25-33.
        View in: PubMed
      192. Morley BJ, Chin KN, Newton ME, Weiss A. The lysine residue in the membrane-spanning domain of the beta chain is necessary for cell surface expression of the T cell antigen receptor. J Exp Med. 1988 Dec 1; 168(6):1971-8.
        View in: PubMed
      193. Goldsmith MA, Dazin PF, Weiss A. At least two non-antigen-binding molecules are required for signal transduction by the T-cell antigen receptor. Proc Natl Acad Sci U S A. 1988 Nov; 85(22):8613-7.
        View in: PubMed
      194. Bockenstedt LK, Goldsmith MA, Dustin M, Olive D, Springer TA, Weiss A. The CD2 ligand LFA-3 activates T cells but depends on the expression and function of the antigen receptor. J Immunol. 1988 Sep 15; 141(6):1904-11.
        View in: PubMed
      195. Goldsmith MA, Weiss A. New clues about T-cell antigen receptor complex function. Immunol Today. 1988 Jul-Aug; 9(7-8):220-2.
        View in: PubMed
      196. Goldsmith MA, Weiss A. Early signal transduction by the antigen receptor without commitment to T cell activation. Science. 1988 May 20; 240(4855):1029-31.
        View in: PubMed
      197. Goldsmith MA, Weiss A. Generation and analysis of a T-lymphocyte somatic mutant for studying molecular aspects of signal transduction by the antigen receptor. Ann N Y Acad Sci. 1988; 546:91-103.
        View in: PubMed
      198. Goldsmith MA, Weiss A. Function of the antigen receptor in T cell activation. Adv Exp Med Biol. 1988; 234:195-211.
        View in: PubMed
      199. Imboden JB, Weiss A. The initiation of human T lymphocyte activation. Prog Allergy. 1988; 42:246-79.
        View in: PubMed
      200. Loh EY, Lanier LL, Turck CW, Littman DR, Davis MM, Chien YH, Weiss A. Identification and sequence of a fourth human T cell antigen receptor chain. Nature. 1987 Dec 10-16; 330(6148):569-72.
        View in: PubMed
      201. Bockenstedt LK, Goldsmith MA, Koretzky GA, Weiss A. The activation of T lymphocytes. Rheum Dis Clin North Am. 1987 Dec; 13(3):411-30.
        View in: PubMed
      202. Weiss A, Dazin PF, Shields R, Fu SM, Lanier LL. Functional competency of T cell antigen receptors in human thymus. J Immunol. 1987 Nov 15; 139(10):3245-50.
        View in: PubMed
      203. Imboden JB, Weiss A. The T-cell antigen receptor regulates sustained increases in cytoplasmic free Ca2+ through extracellular Ca2+ influx and ongoing intracellular Ca2+ mobilization. Biochem J. 1987 Nov 1; 247(3):695-700.
        View in: PubMed
      204. Lanier LL, Serafini AT, Ruitenberg JJ, Cwirla S, Federspiel NA, Phillips JH, Allison JP, Weiss A. The gamma T-cell antigen receptor. J Clin Immunol. 1987 Nov; 7(6):429-40.
        View in: PubMed
      205. Phillips JH, Weiss A, Gemlo BT, Rayner AA, Lanier LL. Evidence that the T cell antigen receptor may not be involved in cytotoxicity mediated by gamma/delta and alpha/beta thymic cell lines. J Exp Med. 1987 Nov 1; 166(5):1579-84.
        View in: PubMed
      206. Manger B, Weiss A, Imboden J, Laing T, Stobo JD. The role of protein kinase C in transmembrane signaling by the T cell antigen receptor complex. Effects of stimulation with soluble or immobilized CD3 antibodies. J Immunol. 1987 Oct 15; 139(8):2755-60.
        View in: PubMed
      207. Goldsmith MA, Weiss A. Isolation and characterization of a T-lymphocyte somatic mutant with altered signal transduction by the antigen receptor. Proc Natl Acad Sci U S A. 1987 Oct; 84(19):6879-83.
        View in: PubMed
      208. Pelicci PG, Subar M, Weiss A, Dalla-Favera R, Littman DR. Molecular diversity of the human T-gamma constant region genes. Science. 1987 Aug 28; 237(4818):1051-5.
        View in: PubMed
      209. Saito T, Weiss A, Gunter KC, Shevach EM, Germain RN. Cell surface T3 expression requires the presence of both alpha- and beta-chains of the T cell receptor. J Immunol. 1987 Jul 15; 139(2):625-8.
        View in: PubMed
      210. Lancki DW, Weiss A, Fitch FW. Requirements for triggering of lysis by cytolytic T lymphocyte clones. J Immunol. 1987 Jun 1; 138(11):3646-53.
        View in: PubMed
      211. Weiss A, Shields R, Newton M, Manger B, Imboden J. Ligand-receptor interactions required for commitment to the activation of the interleukin 2 gene. J Immunol. 1987 Apr 1; 138(7):2169-76.
        View in: PubMed
      212. Lanier LL, Federspiel NA, Ruitenberg JJ, Phillips JH, Allison JP, Littman D, Weiss A. The T cell antigen receptor complex expressed on normal peripheral blood CD4-, CD8- T lymphocytes. A CD3-associated disulfide-linked gamma chain heterodimer. J Exp Med. 1987 Apr 1; 165(4):1076-94.
        View in: PubMed
      213. Gunter KC, Germain RN, Kroczek RA, Saito T, Yokoyama WM, Chan C, Weiss A, Shevach EM. Thy-1-mediated T-cell activation requires co-expression of CD3/Ti complex. Nature. 1987 Apr 2-8; 326(6112):505-7.
        View in: PubMed
      214. Littman DR, Newton M, Crommie D, Ang SL, Seidman JG, Gettner SN, Weiss A. Characterization of an expressed CD3-associated Ti gamma-chain reveals C gamma domain polymorphism. Nature. 1987 Mar 5-11; 326(6108):85-8.
        View in: PubMed
      215. Durand DB, Bush MR, Morgan JG, Weiss A, Crabtree GR. A 275 basepair fragment at the 5' end of the interleukin 2 gene enhances expression from a heterologous promoter in response to signals from the T cell antigen receptor. J Exp Med. 1987 Feb 1; 165(2):395-407.
        View in: PubMed
      216. Weiss A, Imboden J, Hardy K, Stobo J. The role of the antigen receptor/T3 complex in T-cell activation. Adv Exp Med Biol. 1987; 213:45-9.
        View in: PubMed
      217. Saito T, Weiss A, Miller J, Norcross MA, Germain RN. Specific antigen-Ia activation of transfected human T cells expressing murine Ti alpha beta-human T3 receptor complexes. Nature. 1987 Jan 8-14; 325(7000):125-30.
        View in: PubMed
      218. Weiss A, Imboden JB. Cell surface molecules and early events involved in human T lymphocyte activation. Adv Immunol. 1987; 41:1-38.
        View in: PubMed
      219. Lanier LL, Weiss A. Presence of Ti (WT31) negative T lymphocytes in normal blood and thymus. Nature. 1986 Nov 20-26; 324(6094):268-70.
        View in: PubMed
      220. Lanier LL, Ruitenberg JJ, Allison JP, Weiss A. Distinct epitopes on the T cell antigen receptor of HPB-ALL tumor cells identified by monoclonal antibodies. J Immunol. 1986 Oct 1; 137(7):2286-92.
        View in: PubMed
      221. Weiss A, Manger B, Imboden J. Synergy between the T3/antigen receptor complex and Tp44 in the activation of human T cells. J Immunol. 1986 Aug 1; 137(3):819-25.
        View in: PubMed
      222. Manger B, Hardy KJ, Weiss A, Stobo JD. Differential effect of cyclosporin A on activation signaling in human T cell lines. J Clin Invest. 1986 May; 77(5):1501-6.
        View in: PubMed
      223. Manger B, Weiss A, Hardy KJ, Stobo JD. A transferrin receptor antibody represents one signal for the induction of IL 2 production by a human T cell line. J Immunol. 1986 Jan; 136(2):532-8.
        View in: PubMed
      224. Weiss A, Imboden J, Hardy K, Manger B, Terhorst C, Stobo J. The role of the T3/antigen receptor complex in T-cell activation. Annu Rev Immunol. 1986; 4:593-619.
        View in: PubMed
      225. Manger B, Weiss A, Weyand C, Goronzy J, Stobo JD. T cell activation: differences in the signals required for IL 2 production by nonactivated and activated T cells. J Immunol. 1985 Dec; 135(6):3669-73.
        View in: PubMed
      226. Ohashi PS, Mak TW, Van den Elsen P, Yanagi Y, Yoshikai Y, Calman AF, Terhorst C, Stobo JD, Weiss A. Reconstitution of an active surface T3/T-cell antigen receptor by DNA transfer. Nature. 1985 Aug 15-21; 316(6029):606-9.
        View in: PubMed
      227. Wiskocil R, Weiss A, Imboden J, Kamin-Lewis R, Stobo J. Activation of a human T cell line: a two-stimulus requirement in the pretranslational events involved in the coordinate expression of interleukin 2 and gamma-interferon genes. J Immunol. 1985 Mar; 134(3):1599-603.
        View in: PubMed
      228. Imboden JB, Weiss A, Stobo JD. The antigen receptor on a human T cell line initiates activation by increasing cytoplasmic free calcium. J Immunol. 1985 Feb; 134(2):663-5.
        View in: PubMed
      229. Weiss A, Stobo JD. Requirement for the coexpression of T3 and the T cell antigen receptor on a malignant human T cell line. J Exp Med. 1984 Nov 1; 160(5):1284-99.
        View in: PubMed
      230. Weiss A, Wiskocil RL, Stobo JD. The role of T3 surface molecules in the activation of human T cells: a two-stimulus requirement for IL 2 production reflects events occurring at a pre-translational level. J Immunol. 1984 Jul; 133(1):123-8.
        View in: PubMed
      231. Weiss A, Imboden J, Shoback D, Stobo J. Role of T3 surface molecules in human T-cell activation: T3-dependent activation results in an increase in cytoplasmic free calcium. Proc Natl Acad Sci U S A. 1984 Jul; 81(13):4169-73.
        View in: PubMed
      232. Weiss A, Imboden J, Wiskocil R, Stobo J. The role of T3 in the activation of human T cells. J Clin Immunol. 1984 May; 4(3):165-73.
        View in: PubMed
      233. Weiss A, MacDonald HR, Cerottini JC, Brunner KT. Inhibition of cytolytic T lymphocyte clones reactive with Moloney leukemia virus-associated antigens by monoclonal antibodies: a direct approach to the study of H-2 restriction. J Immunol. 1981 Feb; 126(2):482-5.
        View in: PubMed
      234. Weiss A, Brunner KT, MacDonald HR, Cerottini JC. Antigenic specificity of the cytolytic T lymphocyte response to murine sarcoma virus-induced tumors. III. Characterization of cytolytic T lymphocyte clones specific for Moloney leukemia virus-associated cell surface antigens. J Exp Med. 1980 Nov 1; 152(5):1210-25.
        View in: PubMed
      235. Stuart FP, McKearn TJ, Weiss A, Fitch FW. Suppression of rat renal allograft rejection by antigen and antibody. Immunol Rev. 1980; 49:127-65.
        View in: PubMed
      236. McKearn TJ, Weiss A, Stuart FP, Fitch FW. Selective suppression of humoral and cell-mediated immune responses to rat alloantigens by monoclonal antibodies produced by hybridoma cell lines. Transplant Proc. 1979 Mar; 11(1):932-5.
        View in: PubMed
      237. Weiss A, Stuart FP, Fitch FW. Immune reactivity of cells from long-term rat renal allograft survivors. Transplantation. 1978 Nov; 26(5):346-52.
        View in: PubMed
      238. Weiss A, Fitch FW, McKearn TJ, Stuart FP. Immunological memory is regulated in the enhanced rat renal allograft recipient. Nature. 1978 Jun 22; 273(5664):662-4.
        View in: PubMed
      239. Fitch FW, Weiss A, McKearn TJ, Stuart FP. Graft enhancement and antiidiotypic antibody. Lymphocytes from long-term rat renal allograft recipients have normal responsiveness in vitro. Transplant Proc. 1978 Jun; 10(2):367-72.
        View in: PubMed
      240. Weiss A, Fitch FW. Suppression of the plaque-forming cell response by macrophages present in the normal rat spleen. J Immunol. 1978 Feb; 120(2):357-9.
        View in: PubMed
      241. McKearn TJ, Sarmiento M, Weiss A, Stuart FP, Fitch FW. Selective suppression of reactivity to rat histocompatibility antigens by hybridoma antibodies. Curr Top Microbiol Immunol. 1978; 81:61-5.
        View in: PubMed
      242. Weiss A, Stuart FP, Fitch FW. Absence of immunologic memory in recipients of enhanced renal allografts. Surg Forum. 1978; 29:330-3.
        View in: PubMed
      243. Weiss A, Fitch FW. Macrophages suppress CTL generation in rat mixed leukocyte cultures. J Immunol. 1977 Aug; 119(2):510-6.
        View in: PubMed
      244. Weiss A. Suppression of adult rat lymphoid proliferative responses by homologous neonatal serum. J Immunol. 1977 Mar; 118(3):1121-3.
        View in: PubMed
      245. Edidin M, Weiss A. Antigen cap formation in cultured fibroblasts: a reflection of membrane fluidity and of cell motility. Proc Natl Acad Sci U S A. 1972 Sep; 69(9):2456-9.
        View in: PubMed
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