Arthur Weiss, MD, PhD
|School||UCSF School of Medicine|
|Address||513 Parnassus Avenue|
San Francisco CA 94117
|Title||Howard Hughes Investigator|
|University of California, San Francisco||Residency ||Rheumatology|
|UCSF||2012||Lifetime Achievement in Mentoring Award|
|American Association of Immunologists||2012||Lifetime Achievement Award|
|Institute of Medicine||2004||Member|
|American College of Rheumatology||2004||Distinguished Investigator Award|
|National Academy of Sciences||2004||Member|
|American Academy of Arts and Sciences||2003||Fellow|
|American Association of Immunologists||2001||American Association of Immunologists-Huang Foundation Meritorious Career Award|
|UCSF||1998||Forty-first Faculty Research Lecturer|
|Arthritis Foundation||1997||Lee C. Howley Prize|
|American Association of Immunologists||1993||Junior Investigator Award|
|Western Society for Clinical Investigation||1990||Young Investigator Award|
|American College of Rheumatology||1990||Henry Kunkel Young Investigator Award|
The response of lymphocytes to antigen which initiates an antigen specific immune response also represents a unique opportunity to study how complex molecular interactions between cells can lead to developmental decisions, cell differentiation and proliferation. We are interested in understanding how receptors involved in antigen recognition can initiate signal transduction events that regulate cell responses in the immune system. We know that receptors involved in antigen recognition functionally interact with tyrosine kinases and phosphatases, enzymes that regulate protein phosphorylation, to induce signaling pathways that regulate cellular responses and gene expression. We are using genetically selective small molecule inhibitors of kinases together with phosphatase mutants to study how thresholds for the initiation of immune responses are set and how feedback circuits influence responses. We would like to understand how the tyrosine kinases and phosphatases in these pathways are regulated and how they control cellular responses in development, in normal immune responses and in autoimmune diseases such as lupus and rheumatoid arthritis.
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