Iryna Lobach, PhD

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    Collapse Biography 
    Collapse Education and Training
    Texas A&M UniversityPhD2006Statistics
    Yale UniversityPostDoc in Statistical Genetics2008Public Health
    Collapse Awards and Honors
    The International Biometric Society2010Best Paper of the Year in Biometrics Journal

    Collapse Overview 
    Collapse Overview
    Dr. Iryna V. Lobach conducts research in applied statistics and supports the biostatistics component of biomedical research.

    Her methodological research interests are motivated by challenges arising in the analyses of how an effect of the genetic basis varies by non-genetic measures (environment), what is traditionally referred to as gene-environment interaction analyses. This type of analyses might provide valuable clues to the underlying pathophysiologic mechanisms of complex phenotypes. Specifically, in collaboration with statisticians and biomedical researchers, Dr. Lobach developed an efficient retrospective analysis of case-control genetic studies in situations when the environmental variable is measured with error, e.g. diet or physical activity. Both in theory and in practice, this method improves efficiency of the risk parameter estimates and is capable of correcting coverage of 95% Confidence Intervals from e.g. 68% of the standard approach to the nominal 95% in a practical example of analyses of association between calcium intake and the risk of colorectal adenoma analyses. Recently, we developed statistical methods to incorporate heterogeneity in the clinical diagnosis characterized by biomarker studies in situations when 1) multiple distinct pathophysiologic mechanisms share symptoms; and 2) substantial segments of the population are undiagnosed. We show that the genetic variant will appear to interact with the environmental variable if the genetic variant affects the pathologically defined disease state and the environmental variable is related to the proportion of cases with that disease state. We then propose a pseudo-likelihood solution to correct the bias and apply the methods to large genome-wide studies of Prostate Cancer and Alzheimer’s disease.

    Dr. Lobach supports the biostatistics component of multiple biomedical studies through collaboration, consultation (CTSI biostatistics consultant) and mentoring (K-grants, mentoring in the Training in Clinical Research Program).

    Collapse Research 
    Collapse Research Activities and Funding
    Role of the metabolic syndrome profile in genetic susceptibility to Alzheimer's d
    NIH R21AG043710May 15, 2014 - Apr 30, 2016
    Role: Principal Investigator
    Novel Analysis of Gene-Gene and Gene-Environment Interactions in Alcoholism
    NIH R21AA020356Sep 1, 2013 - Aug 31, 2015
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Santos-Santos MA, Rabinovici GD, Iaccarino L, Ayakta N, Tammewar G, Lobach I, Henry ML, Hubbard I, Mandelli ML, Spinelli E, Miller ZA, Pressman PS, O'Neil JP, Ghosh P, Lazaris A, Meyer M, Watson C, Yoon SJ, Rosen HJ, Grinberg L, Seeley WW, Miller BL, Jagust WJ, Gorno-Tempini ML. Rates of Amyloid Imaging Positivity in Patients With Primary Progressive Aphasia. JAMA Neurol. 2018 Jan 08. PMID: 29309493.
      View in: PubMed
    2. Amano K, Huebner JL, Stabler TV, Tanaka M, McCulloch CE, Lobach I, Lane NE, Kraus VB, Ma CB, Li X. Synovial Fluid Profile at the Time of Anterior Cruciate Ligament Reconstruction and Its Association With Cartilage Matrix Composition 3 Years After Surgery. Am J Sports Med. 2018 Jan 01; 363546517749834. PMID: 29364702.
      View in: PubMed
    3. Rojas JC, Bang J, Lobach I, Tsai RM, Rabinovici GD, Miller BL, Boxer AL. CSF neurofilament light chain and phosphorylated tau 181 predict disease progression in PSP. Neurology. 2017 Dec 27. PMID: 29282336.
      View in: PubMed
    4. Ray KM, Kerlikowske K, Lobach IV, Hofmann MB, Greenwood HI, Arasu VA, Hylton NM, Joe BN. Effect of Background Parenchymal Enhancement on Breast MR Imaging Interpretive Performance in Community-based Practices. Radiology. 2017 Oct 25; 170811. PMID: 29072981.
      View in: PubMed
    5. Greenwood HI, Lee AY, Lobach I, Carpentier BM, Freimanis RI, Strachowski LM. Clustered Microcysts on Breast Ultrasound: What Is an Appropriate Management Recommendation? AJR Am J Roentgenol. 2017 Sep 20; W1-W5. PMID: 28929806.
      View in: PubMed
    6. Goetzl EJ, Schwartz JB, Mustapic M, Lobach IV, Daneman R, Abner EL, Jicha GA. Altered cargo proteins of human plasma endothelial cell-derived exosomes in atherosclerotic cerebrovascular disease. FASEB J. 2017 Aug; 31(8):3689-3694. PMID: 28476896.
      View in: PubMed
    7. Carey EJ, Lai JC, Wang CW, Dasarathy S, Lobach I, Montano-Loza AJ, Dunn MA. A multicenter study to define sarcopenia in patients with end-stage liver disease. Liver Transpl. 2017 May; 23(5):625-633. PMID: 28240805.
      View in: PubMed
    8. Woerman AL, Aoyagi A, Patel S, Kazmi SA, Lobach I, Grinberg LT, McKee AC, Seeley WW, Olson SH, Prusiner SB. Tau prions from Alzheimer's disease and chronic traumatic encephalopathy patients propagate in cultured cells. Proc Natl Acad Sci U S A. 2016 Dec 13; 113(50):E8187-E8196. PMID: 27911827.
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    9. Bertoux M, Sarazin M, Pasquier F, Bottlaender M, de Souza LC, Mioshi E, Hornberger M, Ranasinghe KG, Rankin KP, Lobach IV, Kramer JH, Sturm VE, Bettcher BM, Possin K, You SC, Lamarre AK, Shany-Ur T, Stephens ML, Perry DC, Lee SE, Miller ZA, Gorno-Tempini ML, Rosen HJ, Boxer A, Seeley WW, Rabinovici GD, Vossel KA, Miller BL. Cognition and neuropsychiatry in behavioral variant frontotemporal dementia by disease stage. Neurology. 2016 Oct 04; 87(14):1523. PMID: 27698154.
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    10. Heilmeier U, Hackl M, Skalicky S, Weilner S, Schroeder F, Vierlinger K, Patsch J, Baum T, Oberbauer E, Lobach I, Burghardt A, Schwartz A, Grillari J, Link T, et al. Serum miRNA Signatures Are Indicative of Skeletal Fractures in Postmenopausal Women With and Without Type 2 Diabetes and Influence Osteogenic and Adipogenic Differentiation of Adipose Tissue-Derived Mesenchymal Stem Cells In Vitro. J Bone Miner Res. 2016 Dec; 31(12):2173-2192. PMID: 27345526.
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    11. Goetzl EJ, Kapogiannis D, Schwartz JB, Lobach I, Goetzl L, Abner EL, Jicha GA, Karydas AM, Boxer A, Miller BL, et al. Decreased synaptic proteins in neuronal exosomes of frontotemporal dementia and Alzheimer's disease. FASEB J. 2016 Dec; 30(12):4141-4148. PMID: 27601437.
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    12. Ranasinghe KG, Rankin KP, Pressman PS, Perry DC, Lobach I, Seeley WW, Coppola G, Karydas AM, Grinberg LT, Shany-Ur T, Lee SE, Rabinovici GD, Rosen HJ, Gorno-Tempini ML, Boxer AL, Miller ZA, Chiong W, DeMay M, Kramer JH, Possin KL, Sturm VE, Bettcher BM, Neylan M, Zackey DD, Nguyen LA, Ketelle R, Block N, Wu TQ, Dallich A, Russek N, Caplan A, Geschwind DH, Vossel KA, Miller BL, et al. Distinct Subtypes of Behavioral Variant Frontotemporal Dementia Based on Patterns of Network Degeneration. JAMA Neurol. 2016 Sep 01; 73(9):1078-88. PMID: 27429218; PMCID: PMC5024785.
    13. Daud AI, Loo K, Pauli ML, Sanchez-Rodriguez R, Sandoval PM, Taravati K, Tsai K, Nosrati A, Nardo L, Alvarado MD, Algazi AP, Pampaloni MH, Lobach I, Hwang J, Pierce RH, Gratz IK, Krummel MF, Rosenblum MD, et al. Tumor immune profiling predicts response to anti-PD-1 therapy in human melanoma. J Clin Invest. 2016 Sep 01; 126(9):3447-52. PMID: 27525433; PMCID: PMC5004965 [Available on 12/01/16].
    14. Goetzl EJ, Mustapic M, Kapogiannis D, Eitan E, Lobach I, Goetzl L, Schwartz JB, Miller BL, et al. Cargo proteins of plasma astrocyte-derived exosomes in Alzheimer's disease. FASEB J. 2016 Nov; 30(11):3853-3859. PMID: 27511944.
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    15. Roswell RO, Greet B, Shah S, Bernard S, Milin A, Lobach I, Guo Y, Radford MJ, Berger JS. Intravenous heparin dosing strategy in hospitalized patients with atrial dysrhythmias. J Thromb Thrombolysis. 2016 Aug; 42(2):179-85. PMID: 26951166.
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    16. Tsai RM, Lobach I, Bang J, Whitwell JL, Senjem ML, Jack CR, Rosen H, Miller B, Boxer AL. Clinical correlates of longitudinal brain atrophy in progressive supranuclear palsy. Parkinsonism Relat Disord. 2016 Jul; 28:29-35. PMID: 27132501; PMCID: PMC4914401 [Available on 07/01/17].
    17. Bang J, Lobach IV, Lang AE, Grossman M, Knopman DS, Miller BL, Schneider LS, Doody RS, Lees A, Gold M, Morimoto BH, Boxer AL. Predicting disease progression in progressive supranuclear palsy in multicenter clinical trials. Parkinsonism Relat Disord. 2016 Jul; 28:41-48. PMID: 27172829; PMCID: PMC4914418 [Available on 07/01/17].
    18. Stamelou M, Schöpe J, Wagenpfeil S, Del Ser T, Bang J, Lobach I, Luong P, Respondek G, Oertel WH, Boxer A, Höglinger GU. Power calculations and placebo effect for future clinical trials in progressive supranuclear palsy. Mov Disord. 2016 May; 31(5):742-7. PMID: 26948290.
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    19. Smilowitz NR, Maduro GA, Lobach IV, Chen Y, Reynolds HR. Adverse Trends in Ischemic Heart Disease Mortality among Young New Yorkers, Particularly Young Black Women. PLoS One. 2016; 11(2):e0149015. PMID: 26882207; PMCID: PMC4755569.
    20. Ranasinghe KG, Rankin KP, Lobach I, Kramer JH, Sturm VE, Bettcher BM, Possin K, Christine You S, Lamarre AK, Shany-Ur T, Stephens ML, Perry DC, Lee SE, Miller ZA, Gorno-Tempini ML, Rosen HJ, Boxer A, Seeley WW, Rabinovici GD, Vossel KA, Miller BL. Cognition and neuropsychiatry in behavioral variant frontotemporal dementia by disease stage. Neurology. 2016 Feb 16; 86(7):600-10. PMID: 26802093; PMCID: PMC4762418 [Available on 02/16/17].
    21. Caverzasi E, Hervey-Jumper SL, Jordan KM, Lobach I, Li J, Panara V, Racine CA, Sankaranarayanan V, Amirbekian B, Papinutto N, Berger MS, Henry RG. Identifying preoperative language tracts and predicting postoperative functional recovery using HARDI q-ball fiber tractography in patients with gliomas. J Neurosurg. 2016 Jul; 125(1):33-45. PMID: 26654181.
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    22. Schlaeger R, Papinutto N, Zhu AH, Lobach IV, Bevan CJ, Bucci M, Castellano A, Gelfand JM, Graves JS, Green AJ, Jordan KM, Keshavan A, Panara V, Stern WA, von Büdingen HC, Waubant E, Goodin DS, Cree BA, Hauser SL, Henry RG. Association Between Thoracic Spinal Cord Gray Matter Atrophy and Disability in Multiple Sclerosis. JAMA Neurol. 2015 Aug; 72(8):897-904. PMID: 26053119.
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    23. Fan R, Wang Y, Boehnke M, Chen W, Li Y, Ren H, Lobach I, Xiong M. Gene Level Meta-Analysis of Quantitative Traits by Functional Linear Models. Genetics. 2015 Aug; 200(4):1089-104. PMID: 26058849; PMCID: PMC4574252.
    24. Forner SA, Takada LT, Bettcher BM, Lobach I, Tartaglia MC, Torres-Chae C, Haman A, Thai J, Vitali P, Neuhaus J, Bostrom A, Miller BL, Rosen HJ, Geschwind MD. Comparing CSF biomarkers and brain MRI in the diagnosis of sporadic Creutzfeldt-Jakob disease. Neurol Clin Pract. 2015 Apr; 5(2):116-125. PMID: 26137420.
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    25. Quinones A, Lobach I, Maduro GA, Smilowitz NR, Reynolds HR. Diabetes and ischemic heart disease death in people age 25-54: a multiple-cause-of-death analysis based on over 400?000 deaths from 1990 to 2008 in New York City. Clin Cardiol. 2015 Feb; 38(2):114-20. PMID: 25716311.
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    26. Caverzasi E, Mandelli ML, DeArmond SJ, Hess CP, Vitali P, Papinutto N, Oehler A, Miller BL, Lobach IV, Bastianello S, Geschwind MD, Henry RG. White matter involvement in sporadic Creutzfeldt-Jakob disease. Brain. 2014 Dec; 137(Pt 12):3339-54. PMID: 25367029; PMCID: PMC4240303.
    27. Shah B, Burdowski J, Lobach I, Gianos E, Sedlis SP. A risk score for prediction of hyperglycemia at coronary angiography. JACC Cardiovasc Interv. 2014 Oct; 7(10):1199-201. PMID: 25240543; PMCID: PMC4405887.
    28. Fan R, Wang Y, Mills JL, Carter TC, Lobach I, Wilson AF, Bailey-Wilson JE, Weeks DE, Xiong M. Generalized functional linear models for gene-based case-control association studies. Genet Epidemiol. 2014 Nov; 38(7):622-637. PMID: 25203683; PMCID: PMC4189986.
    29. Bettcher BM, Watson CL, Walsh CM, Lobach IV, Neuhaus J, Miller JW, Green R, Patel N, Dutt S, Busovaca E, Rosen HJ, Yaffe K, Miller BL, Kramer JH. Interleukin-6, age, and corpus callosum integrity. PLoS One. 2014; 9(9):e106521. PMID: 25188448; PMCID: PMC4154691.
    30. Schlaeger R, Papinutto N, Panara V, Bevan C, Lobach IV, Bucci M, Caverzasi E, Gelfand JM, Green AJ, Jordan KM, Stern WA, von Büdingen HC, Waubant E, Zhu AH, Goodin DS, Cree BA, Hauser SL, Henry RG. Spinal cord gray matter atrophy correlates with multiple sclerosis disability. Ann Neurol. 2014 Oct; 76(4):568-80. PMID: 25087920.
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    31. Mandelli ML, Caverzasi E, Binney RJ, Henry ML, Lobach I, Block N, Amirbekian B, Dronkers N, Miller BL, Henry RG, Gorno-Tempini ML. Frontal white matter tracts sustaining speech production in primary progressive aphasia. J Neurosci. 2014 Jul 16; 34(29):9754-67. PMID: 25031413; PMCID: PMC4099550.
    32. Wagshal D, Sankaranarayanan S, Guss V, Hall T, Berisha F, Lobach I, Karydas A, Voltarelli L, Scherling C, Heuer H, Tartaglia MC, Miller Z, Coppola G, Ahlijanian M, Soares H, Kramer JH, Rabinovici GD, Rosen HJ, Miller BL, Meredith J, Boxer AL. Divergent CSF t alterations in two common tauopathies: Alzheimer's disease and progressive supranuclear palsy. J Neurol Neurosurg Psychiatry. 2015 Mar; 86(3):244-50. PMID: 24899730; PMCID: PMC4256124.
    33. Boxer AL, Lang AE, Grossman M, Knopman DS, Miller BL, Schneider LS, Doody RS, Lees A, Golbe LI, Williams DR, Corvol JC, Ludolph A, Burn D, Lorenzl S, Litvan I, Roberson ED, Höglinger GU, Koestler M, Jack CR, Van Deerlin V, Randolph C, Lobach IV, Heuer HW, Gozes I, Parker L, Whitaker S, Hirman J, Stewart AJ, Gold M, Morimoto BH. Davunetide in patients with progressive supranuclear palsy: a randomised, double-blind, placebo-controlled phase 2/3 trial. Lancet Neurol. 2014 Jul; 13(7):676-85. PMID: 24873720; PMCID: PMC4129545.
    34. Roswell RO, Greet B, Parikh P, Mignatti A, Freese J, Lobach I, Guo Y, Keller N, Radford M, Bangalore S. From door-to-balloon time to contact-to-device time: predictors of achieving target times in patients with ST-elevation myocardial infarction. Clin Cardiol. 2014 Jul; 37(7):389-94. PMID: 24700343.
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    35. Shah B, Berger JS, Amoroso NS, Mai X, Lorin JD, Danoff A, Schwartzbard AZ, Lobach I, Guo Y, Feit F, Slater J, Attubato MJ, Sedlis SP. Periprocedural glycemic control in patients with diabetes mellitus undergoing coronary angiography with possible percutaneous coronary intervention. Am J Cardiol. 2014 May 01; 113(9):1474-80. PMID: 24630791; PMCID: PMC4018663.
    36. Caverzasi E, Henry RG, Vitali P, Lobach IV, Kornak J, Bastianello S, Dearmond SJ, Miller BL, Rosen HJ, Mandelli ML, Geschwind MD. Application of quantitative DTI metrics in sporadic CJD. Neuroimage Clin. 2014; 4:426-35. PMID: 24624328; PMCID: PMC3950558.
    37. Lobach, I., Fan, R., Manga, P. . Genotype-Based Association Mapping of Complex Diseases: Gene-Gene and Gene-Environment Interactions in Presence of Linkage Disequilibrium. Statistics and Its Interface. 2014; (7):51-60.
    38. Lobach I, Fan R, Manga P, et al. Genotype-based association models of complex diseases to detect gene-gene and gene-environment interactions. Stat Interface. 2014; 7(1):51-60. PMID: 26191336.
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    39. Miller ZA, Mandelli ML, Rankin KP, Henry ML, Babiak MC, Frazier DT, Lobach IV, Bettcher BM, Wu TQ, Rabinovici GD, Graff-Radford NR, Miller BL, Gorno-Tempini ML. Handedness and language learning disability differentially distribute in progressive aphasia variants. Brain. 2013 Nov; 136(Pt 11):3461-73. PMID: 24056533; PMCID: PMC3808687.
    40. Berger JS, Hochman J, Lobach I, Adelman MA, Riles TS, Rockman CB. Modifiable risk factor burden and the prevalence of peripheral artery disease in different vascular territories. J Vasc Surg. 2013 Sep; 58(3):673-81.e1. PMID: 23642926.
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    41. Thaipisuttikul P, Lobach I, Zweig Y, Gurnani A, Galvin JE. Capgras syndrome in Dementia with Lewy Bodies. Int Psychogeriatr. 2013 May; 25(5):843-9. PMID: 23211760; PMCID: PMC4004517.
    42. Shah B, Oberweis B, Tummala L, Amoroso NS, Lobach I, Sedlis SP, Grossi E, Berger JS. Mean platelet volume and long-term mortality in patients undergoing percutaneous coronary intervention. Am J Cardiol. 2013 Jan 15; 111(2):185-9. PMID: 23102880; PMCID: PMC3538911.
    43. Grossman E, Shelley D, Braithwaite RS, Lobach I, Goffin A, Rogers E, Sherman S. Effectiveness of smoking-cessation interventions for urban hospital patients: study protocol for a randomized controlled trial. Trials. 2012 Aug 01; 13:126. PMID: 22852878; PMCID: PMC3502597.
    44. Miller LH, Toklu B, Rauch J, Lorin JD, Lobach I, Sedlis SP. Very long-term clinical follow-up after fractional flow reserve-guided coronary revascularization. J Invasive Cardiol. 2012 Jul; 24(7):309-15. PMID: 22781467.
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    45. Sarpel U, Ayo D, Lobach I, Xu R, Newman E. Inverse relationship between cirrhosis and massive tumours in hepatocellular carcinoma. HPB (Oxford). 2012 Nov; 14(11):741-5. PMID: 23043662; PMCID: PMC3482669.
    46. Lobach I, Fan R, et al. Genotype-Based Bayesian Analysis of Gene-Environment Interactions with Multiple Genetic Markers and Misclassification in Environmental Factors. J Probab Stat. 2012; 2012. PMID: 26180529.
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    47. Wan DW, Tzimas D, Smith JA, Kim S, Araujo J, David R, Lobach I, Sarpel U. Risk factors for early-onset and late-onset hepatocellular carcinoma in Asian immigrants with hepatitis B in the United States. Am J Gastroenterol. 2011 Nov; 106(11):1994-2000. PMID: 21912436.
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    48. Reynolds HR, Srichai MB, Iqbal SN, Slater JN, Mancini GB, Feit F, Pena-Sing I, Axel L, Attubato MJ, Yatskar L, Kalhorn RT, Wood DA, Lobach IV, Hochman JS. Mechanisms of myocardial infarction in women without angiographically obstructive coronary artery disease. Circulation. 2011 Sep 27; 124(13):1414-25. PMID: 21900087; PMCID: PMC3619391.
    49. Bangalore S, Kumar S, Lobach I, Messerli FH. Blood pressure targets in subjects with type 2 diabetes mellitus/impaired fasting glucose: observations from traditional and bayesian random-effects meta-analyses of randomized trials. Circulation. 2011 Jun 21; 123(24):2799-810, 9 p following 810. PMID: 21632497.
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    50. Gany F, Dobslaw R, Ramirez J, Tonda J, Lobach I, Leng J. Mexican urban occupational health in the US: a population at risk. J Community Health. 2011 Apr; 36(2):175-9. PMID: 20614170.
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    51. Carrier E, McNeely J, Lobach I, Tay S, Gourevitch MN, Raven MC. Factors associated with frequent utilization of crisis substance use detoxification services. J Addict Dis. 2011 Apr; 30(2):116-22. PMID: 21491293.
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    52. Lobach I, Mallick B, Carroll RJ. Semiparametric Bayesian analysis of gene-environment interactions with error in measurement of environmental covariates and missing genetic data. Stat Interface. 2011; 4(3):305-316. PMID: 21949562.
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    53. Gany F, Ramirez J, Nierodzick ML, McNish T, Lobach I, Leng J. Cancer portal project: a multidisciplinary approach to cancer care among Hispanic patients. J Oncol Pract. 2011 Jan; 7(1):31-8. PMID: 21532808; PMCID: PMC3014508.
    54. Lobach I, Fan R, Carroll RJ. Genotype-based association mapping of complex diseases: gene-environment interactions with multiple genetic markers and measurement error in environmental exposures. Genet Epidemiol. 2010 Dec; 34(8):792-802. PMID: 21031455; PMCID: PMC3021130.
    55. Reynolds HR, Steckman DA, Tunick PA, Kronzon I, Lobach I, Rosenzweig BP. Normal intima-media thickness on carotid ultrasound reliably excludes an ischemic cause of cardiomyopathy. Am Heart J. 2010 Jun; 159(6):1059-66. PMID: 20569720.
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    56. Lobach I, Carroll RJ, Spinka C, Gail MH, Chatterjee N. Haplotype-based regression analysis and inference of case-control studies with unphased genotypes and measurement errors in environmental exposures. Biometrics. 2008 Sep; 64(3):673-84. PMID: 18047538; PMCID: PMC2672569.
    57. Lobach, I and Fan, R. Genotype-based Bayesian Analysis of Gene-Environment Interactions with Multiple Genetic Markers and Misclassification in Environmental Factors. Journal of Probability and Statistics. 2012.
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