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    Jack Taunton, PhD

    SchoolUCSF School of Medicine
    DepartmentCellular Molecular Pharmacology
    Address600 16th Street
    San Francisco CA 94158
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      Other Positions
      TitleHoward Hughes Investigator

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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Su X, Ditlev JA, Hui E, Xing W, Banjade S, Okrut J, King DS, Taunton J, Rosen MK, Vale RD. Phase separation of signaling molecules promotes T cell receptor signal transduction. Science. 2016 Apr 29; 352(6285):595-9. PMID: 27056844.
        View in: PubMed
      2. Smith GA, Uchida K, Weiss A, Taunton J. Essential biphasic role for JAK3 catalytic activity in IL-2 receptor signaling. Nat Chem Biol. 2016 May; 12(5):373-9. PMID: 27018889.
        View in: PubMed
      3. Carelli JD, Sethofer SG, Smith GA, Miller HR, Simard JL, Merrick WC, Jain RK, Ross NT, Taunton J. Ternatin and improved synthetic variants kill cancer cells by targeting the elongation factor-1A ternary complex. Elife. 2015; 4. PMID: 26651998.
        View in: PubMed
      4. Okrut J, Prakash S, Wu Q, Kelly MJ, Taunton J. Allosteric N-WASP activation by an inter-SH3 domain linker in Nck. Proc Natl Acad Sci U S A. 2015 Nov 24; 112(47):E6436-45. PMID: 26554011; PMCID: PMC4664294 [Available on 05/24/16].
      5. Heo KS, Le NT, Cushman HJ, Giancursio CJ, Chang E, Woo CH, Sullivan MA, Taunton J, Yeh ET, Fujiwara K, Abe J. Disturbed flow-activated p90RSK kinase accelerates atherosclerosis by inhibiting SENP2 function. J Clin Invest. 2015 Mar 2; 125(3):1299-310. PMID: 25689261; PMCID: PMC4362265.
      6. Ruiz-Saenz A, Sandhu M, Carrasco Y, Maglathlin RL, Taunton J, Moasser MM. Targeting HER3 by interfering with its Sec61-mediated cotranslational insertion into the endoplasmic reticulum. Oncogene. 2015 Oct 8; 34(41):5288-94. PMID: 25619841; PMCID: PMC4515412 [Available on 04/08/16].
      7. London N, Miller RM, Krishnan S, Uchida K, Irwin JJ, Eidam O, Gibold L, Cimermancic P, Bonnet R, Shoichet BK, Taunton J. Covalent docking of large libraries for the discovery of chemical probes. Nat Chem Biol. 2014 Dec; 10(12):1066-72. PMID: 25344815; PMCID: PMC4232467.
      8. Krishnan S, Miller RM, Tian B, Mullins RD, Jacobson MP, Taunton J. Design of reversible, cysteine-targeted Michael acceptors guided by kinetic and computational analysis. J Am Chem Soc. 2014 Sep 10; 136(36):12624-30. PMID: 25153195; PMCID: PMC4160273.
      9. Mackinnon AL, Paavilainen VO, Sharma A, Hegde RS, Taunton J. An allosteric Sec61 inhibitor traps nascent transmembrane helices at the lateral gate. Elife. 2014; 3:e01483. PMID: 24497544; PMCID: PMC3913039.
      10. Miller RM, Taunton J. Targeting protein kinases with selective and semipromiscuous covalent inhibitors. Methods Enzymol. 2014; 548:93-116. PMID: 25399643; PMCID: PMC4265651.
      11. Li D, Jin L, Alesi GN, Kim YM, Fan J, Seo JH, Wang D, Tucker M, Gu TL, Lee BH, Taunton J, Magliocca KR, Chen ZG, Shin DM, Khuri FR, Kang S. The prometastatic ribosomal S6 kinase 2-cAMP response element-binding protein (RSK2-CREB) signaling pathway up-regulates the actin-binding protein fascin-1 to promote tumor metastasis. J Biol Chem. 2013 Nov 8; 288(45):32528-38. PMID: 24085294; PMCID: PMC3820886.
      12. Nishino M, Choy JW, Gushwa NN, Oses-Prieto JA, Koupparis K, Burlingame AL, Renslo AR, McKerrow JH, Taunton J. Hypothemycin, a fungal natural product, identifies therapeutic targets in Trypanosoma brucei [corrected]. Elife. 2013; 2:e00712. PMID: 23853713; PMCID: PMC3707081.
      13. Jin L, Li D, Lee JS, Elf S, Alesi GN, Fan J, Kang HB, Wang D, Fu H, Taunton J, Boggon TJ, Tucker M, Gu TL, Chen ZG, Shin DM, Khuri FR, Kang S. p90 RSK2 mediates antianoikis signals by both transcription-dependent and -independent mechanisms. Mol Cell Biol. 2013 Jul; 33(13):2574-85. PMID: 23608533; PMCID: PMC3700113.
      14. Miller RM, Paavilainen VO, Krishnan S, Serafimova IM, Taunton J. Electrophilic fragment-based design of reversible covalent kinase inhibitors. J Am Chem Soc. 2013 Apr 10; 135(14):5298-301. PMID: 23540679; PMCID: PMC3665406.
      15. Paavilainen VO, Taunton J. Proteostasis modulators with discriminating taste. Chem Biol. 2013 Feb 21; 20(2):144-5. PMID: 23438743; PMCID: PMC3647031.
      16. Choy JW, Bryant C, Calvet CM, Doyle PS, Gunatilleke SS, Leung SS, Ang KK, Chen S, Gut J, Oses-Prieto JA, Johnston JB, Arkin MR, Burlingame AL, Taunton J, Jacobson MP, McKerrow JM, Podust LM, Renslo AR. Chemical-biological characterization of a cruzain inhibitor reveals a second target and a mammalian off-target. Beilstein J Org Chem. 2013; 9:15-25. PMID: 23400640; PMCID: PMC3566858.
      17. Le NT, Heo KS, Takei Y, Lee H, Woo CH, Chang E, McClain C, Hurley C, Wang X, Li F, Xu H, Morrell C, Sullivan MA, Cohen MS, Serafimova IM, Taunton J, Fujiwara K, Abe J. A crucial role for p90RSK-mediated reduction of ERK5 transcriptional activity in endothelial dysfunction and atherosclerosis. Circulation. 2013 Jan 29; 127(4):486-99. PMID: 23243209; PMCID: PMC3574639.
      18. Gushwa NN, Kang S, Chen J, Taunton J. Selective targeting of distinct active site nucleophiles by irreversible SRC-family kinase inhibitors. J Am Chem Soc. 2012 Dec 19; 134(50):20214-7. PMID: 23190395; PMCID: PMC3729023.
      19. Lakkaraju AK, Thankappan R, Mary C, Garrison JL, Taunton J, Strub K. Efficient secretion of small proteins in mammalian cells relies on Sec62-dependent posttranslational translocation. Mol Biol Cell. 2012 Jul; 23(14):2712-22. PMID: 22648169; PMCID: PMC3395660.
      20. Serafimova IM, Pufall MA, Krishnan S, Duda K, Cohen MS, Maglathlin RL, McFarland JM, Miller RM, Frödin M, Taunton J. Reversible targeting of noncatalytic cysteines with chemically tuned electrophiles. Nat Chem Biol. 2012 May; 8(5):471-6. PMID: 22466421; PMCID: PMC3657615.
      21. Kapp GT, Liu S, Stein A, Wong DT, Reményi A, Yeh BJ, Fraser JS, Taunton J, Lim WA, Kortemme T. Control of protein signaling using a computationally designed GTPase/GEF orthogonal pair. Proc Natl Acad Sci U S A. 2012 Apr 3; 109(14):5277-82. PMID: 22403064; PMCID: PMC3325720.
      22. Le NT, Takei Y, Shishido T, Woo CH, Chang E, Heo KS, Lee H, Lu Y, Morrell C, Oikawa M, McClain C, Wang X, Tournier C, Molina CA, Taunton J, Yan C, Fujiwara K, Patterson C, Yang J, Abe J. p90RSK targets the ERK5-CHIP ubiquitin E3 ligase activity in diabetic hearts and promotes cardiac apoptosis and dysfunction. Circ Res. 2012 Feb 17; 110(4):536-50. PMID: 22267842; PMCID: PMC3306797.
      23. Maifeld SV, MacKinnon AL, Garrison JL, Sharma A, Kunkel EJ, Hegde RS, Taunton J. Secretory protein profiling reveals TNF-a inactivation by selective and promiscuous Sec61 modulators. Chem Biol. 2011 Sep 23; 18(9):1082-8. PMID: 21944747; PMCID: PMC3855466.
      24. Chen F, Pruett-Miller SM, Huang Y, Gjoka M, Duda K, Taunton J, Collingwood TN, Frodin M, Davis GD. High-frequency genome editing using ssDNA oligonucleotides with zinc-finger nucleases. Nat Methods. 2011 Sep; 8(9):753-5. PMID: 21765410; PMCID: PMC3617923.
      25. Henise JC, Taunton J. Irreversible Nek2 kinase inhibitors with cellular activity. J Med Chem. 2011 Jun 23; 54(12):4133-46. PMID: 21627121; PMCID: PMC3663048.
      26. Elf S, Blevins D, Jin L, Chung TW, Williams IR, Lee BH, Lin JX, Leonard WJ, Taunton J, Khoury HJ, Kang S. p90RSK2 is essential for FLT3-ITD- but dispensable for BCR-ABL-induced myeloid leukemia. Blood. 2011 Jun 23; 117(25):6885-94. PMID: 21527514; PMCID: PMC3128480.
      27. Puthenveedu MA, Lauffer B, Temkin P, Vistein R, Carlton P, Thorn K, Taunton J, Weiner OD, Parton RG, von Zastrow M. Sequence-dependent sorting of recycling proteins by actin-stabilized endosomal microdomains. Cell. 2010 Nov 24; 143(5):761-73. PMID: 21111236; PMCID: PMC3058345.
      28. Oh YT, Liu X, Yue P, Kang S, Chen J, Taunton J, Khuri FR, Sun SY. ERK/ribosomal S6 kinase (RSK) signaling positively regulates death receptor 5 expression through co-activation of CHOP and Elk1. J Biol Chem. 2010 Dec 31; 285(53):41310-9. PMID: 21044953; PMCID: PMC3009856.
      29. Kintner DB, Chen X, Currie J, Chanana V, Ferrazzano P, Baba A, Matsuda T, Cohen M, Orlowski J, Chiu SY, Taunton J, Sun D. Excessive Na+/H+ exchange in disruption of dendritic Na+ and Ca2+ homeostasis and mitochondrial dysfunction following in vitro ischemia. J Biol Chem. 2010 Nov 5; 285(45):35155-68. PMID: 20817726; PMCID: PMC2966129.
      30. Manhas N, Shi Y, Taunton J, Sun D. p90 activation contributes to cerebral ischemic damage via phosphorylation of Na+/H+ exchanger isoform 1. J Neurochem. 2010 Sep 1; 114(5):1476-86. PMID: 20557427; PMCID: PMC2924815.
      31. Lee S, Shuman JD, Guszczynski T, Sakchaisri K, Sebastian T, Copeland TD, Miller M, Cohen MS, Taunton J, Smart RC, Xiao Z, Yu LR, Veenstra TD, Johnson PF. RSK-mediated phosphorylation in the C/EBP{beta} leucine zipper regulates DNA binding, dimerization, and growth arrest activity. Mol Cell Biol. 2010 Jun; 30(11):2621-35. PMID: 20351173; PMCID: PMC2876527.
      32. Kang S, Elf S, Lythgoe K, Hitosugi T, Taunton J, Zhou W, Xiong L, Wang D, Muller S, Fan S, Sun SY, Marcus AI, Gu TL, Polakiewicz RD, Chen ZG, Khuri FR, Shin DM, Chen J. p90 ribosomal S6 kinase 2 promotes invasion and metastasis of human head and neck squamous cell carcinoma cells. J Clin Invest. 2010 Apr; 120(4):1165-77. PMID: 20234090; PMCID: PMC2846050.
      33. Mackinnon AL, Taunton J. Target Identification by Diazirine Photo-Cross-linking and Click Chemistry. Curr Protoc Chem Biol. 2009 Dec; 1:55-73. PMID: 23667793.
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      34. Doehn U, Hauge C, Frank SR, Jensen CJ, Duda K, Nielsen JV, Cohen MS, Johansen JV, Winther BR, Lund LR, Winther O, Taunton J, Hansen SH, Frödin M. RSK is a principal effector of the RAS-ERK pathway for eliciting a coordinate promotile/invasive gene program and phenotype in epithelial cells. Mol Cell. 2009 Aug 28; 35(4):511-22. PMID: 19716794; PMCID: PMC3784321.
      35. Chaturvedi D, Cohen MS, Taunton J, Patel TB. The PKARIalpha subunit of protein kinase A modulates the activation of p90RSK1 and its function. J Biol Chem. 2009 Aug 28; 284(35):23670-81. PMID: 19570980; PMCID: PMC2749142.
      36. Kang S, Elf S, Dong S, Hitosugi T, Lythgoe K, Guo A, Ruan H, Lonial S, Khoury HJ, Williams IR, Lee BH, Roesel JL, Karsenty G, Hanauer A, Taunton J, Boggon TJ, Gu TL, Chen J. Fibroblast growth factor receptor 3 associates with and tyrosine phosphorylates p90 RSK2, leading to RSK2 activation that mediates hematopoietic transformation. Mol Cell Biol. 2009 Apr; 29(8):2105-17. PMID: 19223461; PMCID: PMC2663316.
      37. Chaturvedi D, Gao X, Cohen MS, Taunton J, Patel TB. Rapamycin induces transactivation of the EGFR and increases cell survival. Oncogene. 2009 Mar 5; 28(9):1187-96. PMID: 19151764; PMCID: PMC2653860.
      38. Dehan E, Bassermann F, Guardavaccaro D, Vasiliver-Shamis G, Cohen M, Lowes KN, Dustin M, Huang DC, Taunton J, Pagano M. betaTrCP- and Rsk1/2-mediated degradation of BimEL inhibits apoptosis. Mol Cell. 2009 Jan 16; 33(1):109-16. PMID: 19150432; PMCID: PMC2655121.
      39. Bowers A, West N, Taunton J, Schreiber SL, Bradner JE, Williams RM. Total synthesis and biological mode of action of largazole: a potent class I histone deacetylase inhibitor. J Am Chem Soc. 2008 Aug 20; 130(33):11219-22. PMID: 18642817; PMCID: PMC3090445.
      40. Lu Z, Abe J, Taunton J, Lu Y, Shishido T, McClain C, Yan C, Xu SP, Spangenberg TM, Xu H. Reactive oxygen species-induced activation of p90 ribosomal S6 kinase prolongs cardiac repolarization through inhibiting outward K+ channel activity. Circ Res. 2008 Aug 1; 103(3):269-78. PMID: 18599872; PMCID: PMC2631445.
      41. Visintin C, Tomson BN, Rahal R, Paulson J, Cohen M, Taunton J, Amon A, Visintin R. APC/C-Cdh1-mediated degradation of the Polo kinase Cdc5 promotes the return of Cdc14 into the nucleolus. Genes Dev. 2008 Jan 1; 22(1):79-90. PMID: 18172166; PMCID: PMC2151016.
      42. MacKinnon AL, Garrison JL, Hegde RS, Taunton J. Photo-leucine incorporation reveals the target of a cyclodepsipeptide inhibitor of cotranslational translocation. J Am Chem Soc. 2007 Nov 28; 129(47):14560-1. PMID: 17983236; PMCID: PMC2574519.
      43. Snead JL, Sullivan M, Lowery DM, Cohen MS, Zhang C, Randle DH, Taunton J, Yaffe MB, Morgan DO, Shokat KM. A coupled chemical-genetic and bioinformatic approach to Polo-like kinase pathway exploration. Chem Biol. 2007 Nov; 14(11):1261-72. PMID: 18022565; PMCID: PMC2215327.
      44. Kang S, Dong S, Gu TL, Guo A, Cohen MS, Lonial S, Khoury HJ, Fabbro D, Gilliland DG, Bergsagel PL, Taunton J, Polakiewicz RD, Chen J. FGFR3 activates RSK2 to mediate hematopoietic transformation through tyrosine phosphorylation of RSK2 and activation of the MEK/ERK pathway. Cancer Cell. 2007 Sep; 12(3):201-14. PMID: 17785202; PMCID: PMC2424114.
      45. Rutkowski DT, Kang SW, Goodman AG, Garrison JL, Taunton J, Katze MG, Kaufman RJ, Hegde RS. The role of p58IPK in protecting the stressed endoplasmic reticulum. Mol Biol Cell. 2007 Sep; 18(9):3681-91. PMID: 17567950; PMCID: PMC1951758.
      46. Roux PP, Shahbazian D, Vu H, Holz MK, Cohen MS, Taunton J, Sonenberg N, Blenis J. RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation. J Biol Chem. 2007 May 11; 282(19):14056-64. PMID: 17360704; PMCID: PMC3618456.
      47. Co C, Wong DT, Gierke S, Chang V, Taunton J. Mechanism of actin network attachment to moving membranes: barbed end capture by N-WASP WH2 domains. Cell. 2007 Mar 9; 128(5):901-13. PMID: 17350575; PMCID: PMC2047291.
      48. Cohen MS, Hadjivassiliou H, Taunton J. A clickable inhibitor reveals context-dependent autoactivation of p90 RSK. Nat Chem Biol. 2007 Mar; 3(3):156-60. PMID: 17259979; PMCID: PMC3634365.
      49. Hetzer C, Bisgrove D, Cohen MS, Pedal A, Kaehlcke K, Speyerer A, Bartscherer K, Taunton J, Ott M. Recruitment and activation of RSK2 by HIV-1 Tat. PLoS One. 2007; 2(1):e151. PMID: 17225856; PMCID: PMC1764712.
      50. Cuello F, Snabaitis AK, Cohen MS, Taunton J, Avkiran M. Evidence for direct regulation of myocardial Na+/H+ exchanger isoform 1 phosphorylation and activity by 90-kDa ribosomal S6 kinase (RSK): effects of the novel and specific RSK inhibitor fmk on responses to alpha1-adrenergic stimulation. Mol Pharmacol. 2007 Mar; 71(3):799-806. PMID: 17142297.
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      51. Oyadomari S, Yun C, Fisher EA, Kreglinger N, Kreibich G, Oyadomari M, Harding HP, Goodman AG, Harant H, Garrison JL, Taunton J, Katze MG, Ron D. Cotranslocational degradation protects the stressed endoplasmic reticulum from protein overload. Cell. 2006 Aug 25; 126(4):727-39. PMID: 16923392.
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      52. Shahbazian D, Roux PP, Mieulet V, Cohen MS, Raught B, Taunton J, Hershey JW, Blenis J, Pende M, Sonenberg N. The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity. EMBO J. 2006 Jun 21; 25(12):2781-91. PMID: 16763566; PMCID: PMC1500846.
      53. Garrison JL, Kunkel EJ, Hegde RS, Taunton J. A substrate-specific inhibitor of protein translocation into the endoplasmic reticulum. Nature. 2005 Jul 14; 436(7048):285-9. PMID: 16015336.
        View in: PubMed
      54. Cohen MS, Zhang C, Shokat KM, Taunton J. Structural bioinformatics-based design of selective, irreversible kinase inhibitors. Science. 2005 May 27; 308(5726):1318-21. PMID: 15919995; PMCID: PMC3641834.
      55. Papayannopoulos V, Co C, Prehoda KE, Snapper S, Taunton J, Lim WA. A polybasic motif allows N-WASP to act as a sensor of PIP(2) density. Mol Cell. 2005 Jan 21; 17(2):181-91. PMID: 15664188.
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      56. Deng S, Taunton J. Organolithium-mediated diversification of peptide thiazoles. Org Lett. 2005 Jan 20; 7(2):299-301. PMID: 15646982.
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      57. Deng S, Taunton J. Kinetic control of proline amide rotamers: total synthesis of trans,trans- and cis,cis-ceratospongamide. J Am Chem Soc. 2002 Feb 13; 124(6):916-7. PMID: 11829594.
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      58. Taunton J. Actin filament nucleation by endosomes, lysosomes and secretory vesicles. Curr Opin Cell Biol. 2001 Feb; 13(1):85-91. PMID: 11163138.
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      59. Taunton J. How to starve a tumor. Chem Biol. 1997 Jul; 4(7):493-6. PMID: 9263636.
        View in: PubMed
      60. Taunton, J., Hassig, C.A. and Schreiber, S.L. . . A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p. Science. 1996; (272):408-411.
      61. Taunton, J., Collins, J.L. and Schreiber, S.L. . . Synthesis of natural and modified trapoxins, useful reagents for exploring histone deacetylase function. J. Am. Chem. Soc. 1996; (118):10412-10422.
      62. Taunton, J., Wood, J.L. and Schreiber, S.L. . . Total syntheses of di- and tri-O-methyl dynemicin A methyl esters. J. Am. Chem. Soc. 1993; (115):10378-10379.
      63. Wood, J.L., Porco, J.A., Taunton, J., Lee, A.Y., Clardy, J. and Schreiber, S.L. . . Application of the Allylic Diazene Rearrangement: Synthesis of the enediyne-bridged tricyclic core of dynemicin A. J. Am. Chem. Soc. 1992; (114):5898-5900.
      64. Doyle, M.P., Pieters, R.J., Taunton, J., Pho, H.Q., Padwa, A., Hertzog, D.L. and Precedo, L. . Synthesis of nitrogen-containing polycycles via rhodium(II)-induced cyclization-cycloaddition and insertion reactions of N-(diazoacetoacetyl)amides. Conformational control of reaction selectivity. J. Org. Chem. 1991; (56):820-829.
      65. Doyle, M.P., Taunton, J. and Pho, H.Q. . Conformational and electronic preferences in rhodium(II) carboxylate and rhodium(II) carboxamide catalyzed carbon-hydrogen insertion reactions of N,N-disubstituted diazoacetoacetamides. Tetrahedron Lett. 1989; (30):5397-5400.
      66. Doyle, M.P., Taunton, J., Oon, S.M., Liu, M.T., Soundararajan, N., Platz, M.S. and Jackson, J.E. . Reactivity and selectivity in intermolecular insertion reactions of chlorophenylcarbene. Tetrahedron Lett. 1988; (29):5863-5866.
      67. Bagheri, V., Doyle, M.P., Taunton, J. and Claxton, E.E. . A new and general synthesis of a-silyl carbonyl compounds by silicon-hydrogen insertion from transition metal-catalyzed reactions of diazo esters and diazo ketones. J. Org. Chem. 1988; (53):6158-6160.
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