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    Jim Barkovich, MD

    SchoolUCSF School of Medicine
    Address505 Parnassus Avenue
    San Francisco CA 94117
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      Collapse Biography 
      Collapse Education and Training
      George Washington UniversityM.D.School of Medicine1980
      Letterman Army Medical CenterInternship1981
      Letterman Army Medical CenterResidencyRadiology1984
      Walter Reed Army Medical CenterFellowshipNeuroradiology1986
      Collapse Awards and Honors
      University of California, San Francisco2014Outstanding Clinical Research Lecture
      Academy of Radiology Research 2013Distinguished Investigator Award
      Radiological Society of North America2012Outstanding Achievement in Research Award
      American Society of Neuroradiology2012Gold Medalist
      Neuroradiology Education and Research Foundation2008Outstanding Contributions in Research Award
      Boston Children’s Hospital/Harvard Medical School2006Michael J. Bresnan Lecturer in Child Neurology
      American Society of Pediatric Neuroradiology2006Gold Medalist
      German-Austrian-Swiss Society of Child Neurology2005Peter Emil Becker Award for Outstanding Contributions to Child Neurology and Pediatric Neuroradiolog
      University of California, San Francisco Department of Neurology2005Bruce O. Berg Lecturer
      2002 - 2014America's Top Doctors
      Secretary General 2002 - 2006World Federation of Neuroradiological Socieities
      President 1998 - 1999American Society of Neuroradiology
      United Cerebral Palsy Research Foundation1998Goldenson Technology Award
      Armed Forces Institute of Pathology1996Nycomed Distinguished Visiting Lecturer
      1995 - 2009Best Doctors in America
      University of California, San Francisco Department of Neurology1990Outstanding Teacher Award

      Collapse Overview 
      Collapse Overview
      A. James Barkovich, MD, is a Professor in Residence and he is Chief of Pediatric Neuroradiology in the Department of Radiology at the University of California, San Francisco. Dr. Barkovich received his medical degree from George Washington University, Washington, D.C., and completed his residency in Radiology from Letterman AMC, San Francisco in 1984, followed by a fellowship in Neuroradiology from Walter Reed AMC in 1986. Dr. Barkovich was also President of the American Society of Neuroradiology 1998-1999 and Secretary General of the World Federation of Neuroradiological Societies from 2002-2006.

      Dr. Barkovich serves as the Chief of Pediatric Neuroradiology in the UCSF Department of Radiology and Biomedical Imaging. He specializes in the diagnosis of neurological disorders in infants and children. His main research interests include neonatal brain injury and the use of magnetic resonance (MR) to better understand both normal brain development and to recognize and classify genetic disorders that underlie abnormal brain development.

      Dr. Barkovich’s research established correlations between MR findings and the outcome in affected patients. He has 385 published articles, and has authored or co-authored 9 textbooks and 41 book chapters, and he has written and contributed to a collective of more than 400 research documents.


      Pediatric Neuroradiology

      Professional Interests:
      Neonatal brain injury and the use of magnetic resonance (MR) to better understand both normal brain development and to recognize and classify genetic disorders that underlie abnormal brain development

      Education and Training:
      • Medical School: George Washington University, Washington, DC (1976-1980)
      • Internship: Letterman AMC, San Francisco - Radiology (1980-1981)
      • Residency: Letterman AMC, San Francisco - Radiology (1981-1984)
      • Fellowship: Walter Reed AMC, Washington, DC - Neuroradiology (1984-1986)
      • California Medical License
      • Ohio State Medical License (inactive)
      • New York State Medical License (inactive)
      • American Board of Radiology (1984)
      • Certificate of Added Qualification in Neuroradiology (1996, 2006)

      Collapse Interests
      Pediatric Neuroradiology, neonatal brain injury, use of magnetic resonance imaging (MRI) to better understand both normal brain development and to recognize and classify genetic disorders that underlie abnormal brain development.

      Collapse ORNG Applications 
      Collapse Websites
      Collapse In The News
      Collapse Awarded Grants
      Collapse Featured Videos
      Collapse Featured Publications

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Barkovich AJ, Deon S. Reprint of "Hypomyelinating disorders: An MRI approach. Neurobiol Dis. 2016 Aug; 92(Pt A):46-54. PMID: 27235001.
        View in: PubMed
      2. Barkovich AJ. Hypomyelinating disorders: An MRI approach. Neurobiol Dis. 2016 Mar; 87:50-8. PMID: 26477299.
        View in: PubMed
      3. Al-Maawali A, Barry BJ, Rajab A, El-Quessny M, Seman A, Coury SN, Barkovich AJ, Yang E, Walsh CA, Mochida GH, Stoler JM. Novel loss-of-function variants in DIAPH1 associated with syndromic microcephaly, blindness, and early onset seizures. Am J Med Genet A. 2016 Feb; 170(2):435-40. PMID: 26463574.
        View in: PubMed
      4. Fullerton HJ, Hills NK, Elkind MS, Dowling MM, Wintermark M, Glaser CA, Tan M, Rivkin MJ, Titomanlio L, Barkovich AJ, deVeber GA. Infection, vaccination, and childhood arterial ischemic stroke: Results of the VIPS study. Neurology. 2015 Oct 27; 85(17):1459-66. PMID: 26423434; PMCID: PMC4631070 [Available on 10/27/16].
      5. Takanashi J, Mizuguchi M, Terai M, Barkovich AJ. Disrupted glutamate-glutamine cycle in acute encephalopathy with biphasic seizures and late reduced diffusion. Neuroradiology. 2015 Nov; 57(11):1163-8. PMID: 26298309.
        View in: PubMed
      6. Tunovic S, Barañano KW, Barkovich JA, Strober JB, Jamal L, Slavotinek AM. Novel KIF7 missense substitutions in two patients presenting with multiple malformations and features of acrocallosal syndrome. Am J Med Genet A. 2015 Nov; 167(11):2767-76. PMID: 26174511.
        View in: PubMed
      7. Wheway G, Schmidts M, Mans DA, Szymanska K, Nguyen TM, Racher H, Phelps IG, Toedt G, Kennedy J, Wunderlich KA, Sorusch N, Abdelhamed ZA, Natarajan S, Herridge W, van Reeuwijk J, Horn N, Boldt K, Parry DA, Letteboer SJ, Roosing S, Adams M, Bell SM, Bond J, Higgins J, Morrison EE, Tomlinson DC, Slaats GG, van Dam TJ, Huang L, Kessler K, Giessl A, Logan CV, Boyle EA, Shendure J, Anazi S, Aldahmesh M, Al Hazzaa S, Hegele RA, Ober C, Frosk P, Mhanni AA, Chodirker BN, Chudley AE, Lamont R, Bernier FP, Beaulieu CL, Gordon P, Pon RT, Donahue C, Barkovich AJ, Wolf L, Toomes C, Thiel CT, Boycott KM, McKibbin M, Inglehearn CF, Stewart F, Omran H, Huynen MA, Sergouniotis PI, Alkuraya FS, Parboosingh JS, Innes AM, Willoughby CE, Giles RH, Webster AR, Ueffing M, Blacque O, Gleeson JG, Wolfrum U, Beales PL, Gibson T, Doherty D, Mitchison HM, Roepman R, Johnson CA. An siRNA-based functional genomics screen for the identification of regulators of ciliogenesis and ciliopathy genes. Nat Cell Biol. 2015 Aug; 17(8):1074-87. PMID: 26167768; PMCID: PMC4536769 [Available on 02/01/16].
      8. Gano D, Andersen SK, Glass HC, Rogers EE, Glidden DV, Barkovich AJ, Ferriero DM. Impaired cognitive performance in premature newborns with two or more surgeries prior to term-equivalent age. Pediatr Res. 2015 Sep; 78(3):323-9. PMID: 26020148; PMCID: PMC4540651 [Available on 03/01/16].
      9. Barkovich AJ, Dobyns WB, Guerrini R. Malformations of cortical development and epilepsy. Cold Spring Harb Perspect Med. 2015 May; 5(5):a022392. PMID: 25934463.
        View in: PubMed
      10. Esmaeeli Nieh S, Madou MR, Sirajuddin M, Fregeau B, McKnight D, Lexa K, Strober J, Spaeth C, Hallinan BE, Smaoui N, Pappas JG, Burrow TA, McDonald MT, Latibashvili M, Leshinsky-Silver E, Lev D, Blumkin L, Vale RD, Barkovich AJ, Sherr EH. De novo mutations in KIF1A cause progressive encephalopathy and brain atrophy. Ann Clin Transl Neurol. 2015 Jun; 2(6):623-35. PMID: 26125038; PMCID: PMC4479523.
      11. Nakayama T, Al-Maawali A, El-Quessny M, Rajab A, Khalil S, Stoler JM, Tan WH, Nasir R, Schmitz-Abe K, Hill RS, Partlow JN, Al-Saffar M, Servattalab S, LaCoursiere CM, Tambunan DE, Coulter ME, Elhosary PC, Gorski G, Barkovich AJ, Markianos K, Poduri A, Mochida GH. Mutations in PYCR2, Encoding Pyrroline-5-Carboxylate Reductase 2, Cause Microcephaly and Hypomyelination. Am J Hum Genet. 2015 May 7; 96(5):709-19. PMID: 25865492; PMCID: PMC4570282.
      12. D'Gama AM, Geng Y, Couto JA, Martin B, Boyle EA, LaCoursiere CM, Hossain A, Hatem NE, Barry BJ, Kwiatkowski DJ, Vinters HV, Barkovich AJ, Shendure J, Mathern GW, Walsh CA, Poduri A. Mammalian target of rapamycin pathway mutations cause hemimegalencephaly and focal cortical dysplasia. Ann Neurol. 2015 Apr; 77(4):720-5. PMID: 25599672; PMCID: PMC4471336 [Available on 04/01/16].
      13. Vulto-van Silfhout AT, Nakagawa T, Bahi-Buisson N, Haas SA, Hu H, Bienek M, Vissers LE, Gilissen C, Tzschach A, Busche A, Müsebeck J, Rump P, Mathijssen IB, Avela K, Somer M, Doagu F, Philips AK, Rauch A, Baumer A, Voesenek K, Poirier K, Vigneron J, Amram D, Odent S, Nawara M, Obersztyn E, Lenart J, Charzewska A, Lebrun N, Fischer U, Nillesen WM, Yntema HG, Järvelä I, Ropers HH, de Vries BB, Brunner HG, van Bokhoven H, Raymond FL, Willemsen MA, Chelly J, Xiong Y, Barkovich AJ, Kalscheuer VM, Kleefstra T, de Brouwer AP. Variants in CUL4B are associated with cerebral malformations. Hum Mutat. 2015 Jan; 36(1):106-17. PMID: 25385192; PMCID: PMC4608231.
      14. Tate MC, Lindquist RA, Nguyen T, Sanai N, Barkovich AJ, Huang EJ, Rowitch DH, Alvarez-Buylla A. Postnatal growth of the human pons: a morphometric and immunohistochemical analysis. J Comp Neurol. 2015 Feb 15; 523(3):449-62. PMID: 25307966; PMCID: PMC4270924 [Available on 02/15/16].
      15. Wintermark M, Hills NK, deVeber GA, Barkovich AJ, Elkind MS, Sear K, Zhu G, Leiva-Salinas C, Hou Q, Dowling MM, Bernard TJ, Friedman NR, Ichord RN, Fullerton HJ. Arteriopathy diagnosis in childhood arterial ischemic stroke: results of the vascular effects of infection in pediatric stroke study. Stroke. 2014 Dec; 45(12):3597-605. PMID: 25388419; PMCID: PMC4260818 [Available on 12/01/15].
      16. Jissendi-Tchofo P, Severino M, Nguema-Edzang B, Toure C, Soto Ares G, Barkovich AJ. Update on neuroimaging phenotypes of mid-hindbrain malformations. Neuroradiology. 2015 Feb; 57(2):113-38. PMID: 25339235.
        View in: PubMed
      17. Kanal E, Froelich J, Barkovich AJ, Borgstede J, Bradley W, Gimbel JR, Gosbee J, Greenberg T, Jackson E, Larson P, Lester J, Sebek E, Shellock FG, Weinreb J, Wilkoff BL, Hernandez D. Standardized MR terminology and reporting of implants and devices as recommended by the American College of Radiology Subcommittee on MR Safety. Radiology. 2015 Mar; 274(3):866-70. PMID: 25329683.
        View in: PubMed
      18. Gano D, Andersen SK, Partridge JC, Bonifacio SL, Xu D, Glidden DV, Ferriero DM, Barkovich AJ, Glass HC. Diminished white matter injury over time in a cohort of premature newborns. J Pediatr. 2015 Jan; 166(1):39-43. PMID: 25311709; PMCID: PMC4274204 [Available on 01/01/16].
      19. Wang DD, Benkli B, Auguste KI, Garcia PA, Sullivan J, Barkovich AJ, Chang EF, Tihan T. Unilateral holohemispheric central nervous system lesions associated with medically refractory epilepsy in the pediatric population: a retrospective series of hemimegalencephaly and Rasmussen's encephalitis. J Neurosurg Pediatr. 2014 Dec; 14(6):573-84. PMID: 25303156.
        View in: PubMed
      20. De Ciantis A, Barkovich AJ, Cosottini M, Barba C, Montanaro D, Costagli M, Tosetti M, Biagi L, Dobyns WB, Guerrini R. Ultra-high-field MR imaging in polymicrogyria and epilepsy. AJNR Am J Neuroradiol. 2015 Feb; 36(2):309-16. PMID: 25258368.
        View in: PubMed
      21. Rogers EE, Bonifacio SL, Glass HC, Juul SE, Chang T, Mayock DE, Durand DJ, Song D, Barkovich AJ, Ballard RA, Wu YW. Erythropoietin and hypothermia for hypoxic-ischemic encephalopathy. Pediatr Neurol. 2014 Nov; 51(5):657-62. PMID: 25439577; PMCID: PMC4402201.
      22. Jamuar SS, Lam AT, Kircher M, D'Gama AM, Wang J, Barry BJ, Zhang X, Hill RS, Partlow JN, Rozzo A, Servattalab S, Mehta BK, Topcu M, Amrom D, Andermann E, Dan B, Parrini E, Guerrini R, Scheffer IE, Berkovic SF, Leventer RJ, Shen Y, Wu BL, Barkovich AJ, Sahin M, Chang BS, Bamshad M, Nickerson DA, Shendure J, Poduri A, Yu TW, Walsh CA. Somatic mutations in cerebral cortical malformations. N Engl J Med. 2014 Aug 21; 371(8):733-43. PMID: 25140959; PMCID: PMC4274952.
      23. Pouwels PJ, Vanderver A, Bernard G, Wolf NI, Dreha-Kulczewksi SF, Deoni SC, Bertini E, Kohlschütter A, Richardson W, Ffrench-Constant C, Köhler W, Rowitch D, Barkovich AJ. Hypomyelinating leukodystrophies: translational research progress and prospects. Ann Neurol. 2014 Jul; 76(1):5-19. PMID: 24916848.
        View in: PubMed
      24. Tunovic S, Barkovich J, Sherr EH, Slavotinek AM. De novo ANKRD11 and KDM1A gene mutations in a male with features of KBG syndrome and Kabuki syndrome. Am J Med Genet A. 2014 Jul; 164A(7):1744-9. PMID: 24838796.
        View in: PubMed
      25. Tymofiyeva O, Hess CP, Xu D, Barkovich AJ. Structural MRI connectome in development: challenges of the changing brain. Br J Radiol. 2014 Jul; 87(1039):20140086. PMID: 24827379; PMCID: PMC4075590.
      26. Tymofiyeva O, Ziv E, Barkovich AJ, Hess CP, Xu D. Brain without anatomy: construction and comparison of fully network-driven structural MRI connectomes. PLoS One. 2014; 9(5):e96196. PMID: 24789312; PMCID: PMC4006896.
      27. Jenster M, Bonifacio SL, Ruel T, Rogers EE, Tam EW, Partridge JC, Barkovich AJ, Ferriero DM, Glass HC. Maternal or neonatal infection: association with neonatal encephalopathy outcomes. Pediatr Res. 2014 Jul; 76(1):93-9. PMID: 24713817; PMCID: PMC4062582.
      28. Mirzaa GM, Millen KJ, Barkovich AJ, Dobyns WB, Paciorkowski AR. The Developmental Brain Disorders Database (DBDB): a curated neurogenetics knowledge base with clinical and research applications. Am J Med Genet A. 2014 Jun; 164A(6):1503-11. PMID: 24700709; PMCID: PMC4279915.
      29. Bae BI, Tietjen I, Atabay KD, Evrony GD, Johnson MB, Asare E, Wang PP, Murayama AY, Im K, Lisgo SN, Overman L, Šestan N, Chang BS, Barkovich AJ, Grant PE, Topçu M, Politsky J, Okano H, Piao X, Walsh CA. Evolutionarily dynamic alternative splicing of GPR56 regulates regional cerebral cortical patterning. Science. 2014 Feb 14; 343(6172):764-8. PMID: 24531968; PMCID: PMC4480613.
      30. Edwards TJ, Sherr EH, Barkovich AJ, Richards LJ. Clinical, genetic and imaging findings identify new causes for corpus callosum development syndromes. Brain. 2014 Jun; 137(Pt 6):1579-613. PMID: 24477430; PMCID: PMC4032094.
      31. Poduri A, Heinzen EL, Chitsazzadeh V, Lasorsa FM, Elhosary PC, LaCoursiere CM, Martin E, Yuskaitis CJ, Hill RS, Atabay KD, Barry B, Partlow JN, Bashiri FA, Zeidan RM, Elmalik SA, Kabiraj MM, Kothare S, Stödberg T, McTague A, Kurian MA, Scheffer IE, Barkovich AJ, Palmieri F, Salih MA, Walsh CA. SLC25A22 is a novel gene for migrating partial seizures in infancy. Ann Neurol. 2013 Dec; 74(6):873-82. PMID: 24596948; PMCID: PMC4031329.
      32. Ziv E, Tymofiyeva O, Ferriero DM, Barkovich AJ, Hess CP, Xu D. A machine learning approach to automated structural network analysis: application to neonatal encephalopathy. PLoS One. 2013; 8(11):e78824. PMID: 24282501; PMCID: PMC3840059.
      33. Takanashi J, Nitta N, Iwasaki N, Saito S, Tanaka R, Barkovich AJ, Aoki I. Neurochemistry in shiverer mouse depicted on MR spectroscopy. J Magn Reson Imaging. 2014 Jun; 39(6):1550-7. PMID: 24243812.
        View in: PubMed
      34. Adachi Y, Mochida G, Walsh C, Barkovich J. Posterior fossa in primary microcephaly: relationships between forebrain and mid-hindbrain size in 110 patients. Neuropediatrics. 2014 Apr; 45(2):93-101. PMID: 24234199.
        View in: PubMed
      35. Sajan SA, Fernandez L, Nieh SE, Rider E, Bukshpun P, Wakahiro M, Christian SL, Rivière JB, Sullivan CT, Sudi J, Herriges MJ, Paciorkowski AR, Barkovich AJ, Glessner JT, Millen KJ, Hakonarson H, Dobyns WB, Sherr EH. Both rare and de novo copy number variants are prevalent in agenesis of the corpus callosum but not in cerebellar hypoplasia or polymicrogyria. PLoS Genet. 2013; 9(10):e1003823. PMID: 24098143; PMCID: PMC3789824.
      36. Hills LB, Masri A, Konno K, Kakegawa W, Lam AT, Lim-Melia E, Chandy N, Hill RS, Partlow JN, Al-Saffar M, Nasir R, Stoler JM, Barkovich AJ, Watanabe M, Yuzaki M, Mochida GH. Deletions in GRID2 lead to a recessive syndrome of cerebellar ataxia and tonic upgaze in humans. Neurology. 2013 Oct 15; 81(16):1378-86. PMID: 24078737; PMCID: PMC3806907.
      37. Shiba N, Daza RA, Shaffer LG, Barkovich AJ, Dobyns WB, Hevner RF. Neuropathology of brain and spinal malformations in a case of monosomy 1p36. Acta Neuropathol Commun. 2013; 1:45. PMID: 24252393; PMCID: PMC3893467.
      38. Curry CJ, Rosenfeld JA, Grant E, Gripp KW, Anderson C, Aylsworth AS, Saad TB, Chizhikov VV, Dybose G, Fagerberg C, Falco M, Fels C, Fichera M, Graakjaer J, Greco D, Hair J, Hopkins E, Huggins M, Ladda R, Li C, Moeschler J, Nowaczyk MJ, Ozmore JR, Reitano S, Romano C, Roos L, Schnur RE, Sell S, Suwannarat P, Svaneby D, Szybowska M, Tarnopolsky M, Tervo R, Tsai AC, Tucker M, Vallee S, Wheeler FC, Zand DJ, Barkovich AJ, Aradhya S, Shaffer LG, Dobyns WB. The duplication 17p13.3 phenotype: analysis of 21 families delineates developmental, behavioral and brain abnormalities, and rare variant phenotypes. Am J Med Genet A. 2013 Aug; 161A(8):1833-52. PMID: 23813913.
        View in: PubMed
      39. Dimitropoulos A, McQuillen PS, Sethi V, Moosa A, Chau V, Xu D, Brant R, Azakie A, Campbell A, Barkovich AJ, Poskitt KJ, Miller SP. Brain injury and development in newborns with critical congenital heart disease. Neurology. 2013 Jul 16; 81(3):241-8. PMID: 23771484; PMCID: PMC3770166.
      40. Tymofiyeva O, Hess CP, Ziv E, Lee PN, Glass HC, Ferriero DM, Barkovich AJ, Xu D. A DTI-based template-free cortical connectome study of brain maturation. PLoS One. 2013; 8(5):e63310. PMID: 23675475; PMCID: PMC3652871.
      41. Takanashi J, Osaka H, Saitsu H, Sasaki M, Mori H, Shibayama H, Tanaka M, Nomura Y, Terao Y, Inoue K, Matsumoto N, Barkovich AJ. Different patterns of cerebellar abnormality and hypomyelination between POLR3A and POLR3B mutations. Brain Dev. 2014 Mar; 36(3):259-63. PMID: 23643445.
        View in: PubMed
      42. Doherty D, Millen KJ, Barkovich AJ. Midbrain and hindbrain malformations: advances in clinical diagnosis, imaging, and genetics. Lancet Neurol. 2013 Apr; 12(4):381-93. PMID: 23518331; PMCID: PMC4158743.
      43. Wickremasinghe AC, Rogers EE, Johnson BC, Shen A, Barkovich AJ, Marco EJ. Children born prematurely have atypical sensory profiles. J Perinatol. 2013 Aug; 33(8):631-5. PMID: 23412641; PMCID: PMC3738436.
      44. Sethi V, Tabbutt S, Dimitropoulos A, Harris KC, Chau V, Poskitt K, Campbell A, Azakie A, Xu D, Barkovich AJ, Miller SP, McQuillen PS. Single-ventricle anatomy predicts delayed microstructural brain development. Pediatr Res. 2013 May; 73(5):661-7. PMID: 23407116; PMCID: PMC3631295.
      45. Barkovich J. Complication begets clarification in classification. Brain. 2013 Feb; 136(Pt 2):368-73. PMID: 23413256; PMCID: PMC3572928.
      46. Kanal E, Barkovich AJ, Bell C, Borgstede JP, Bradley WG, Froelich JW, Gimbel JR, Gosbee JW, Kuhni-Kaminski E, Larson PA, Lester JW, Nyenhuis J, Schaefer DJ, Sebek EA, Weinreb J, Wilkoff BL, Woods TO, Lucey L, Hernandez D. ACR guidance document on MR safe practices: 2013. J Magn Reson Imaging. 2013 Mar; 37(3):501-30. PMID: 23345200.
        View in: PubMed
      47. Xu D, Mukherjee P, Barkovich AJ. Pediatric brain injury: can DTI scalars predict functional outcome? Pediatr Radiol. 2013 Jan; 43(1):55-9. PMID: 23288477; PMCID: PMC3755904.
      48. Dies KA, Bodell A, Hisama FM, Guo CY, Barry B, Chang BS, Barkovich AJ, Walsh CA. Schizencephaly: association with young maternal age, alcohol use, and lack of prenatal care. J Child Neurol. 2013 Feb; 28(2):198-203. PMID: 23266945; PMCID: PMC3876412.
      49. Aldinger KA, Kogan J, Kimonis V, Fernandez B, Horn D, Klopocki E, Chung B, Toutain A, Weksberg R, Millen KJ, Barkovich AJ, Dobyns WB. Cerebellar and posterior fossa malformations in patients with autism-associated chromosome 22q13 terminal deletion. Am J Med Genet A. 2013 Jan; 161A(1):131-6. PMID: 23225497; PMCID: PMC3733662.
      50. Wang DD, Deans AE, Barkovich AJ, Tihan T, Barbaro NM, Garcia PA, Chang EF. Transmantle sign in focal cortical dysplasia: a unique radiological entity with excellent prognosis for seizure control. J Neurosurg. 2013 Feb; 118(2):337-44. PMID: 23216463.
        View in: PubMed
      51. Takanashi J, Okamoto N, Yamamoto Y, Hayashi S, Arai H, Takahashi Y, Maruyama K, Mizuno S, Shimakawa S, Ono H, Oyanagi R, Kubo S, Barkovich AJ, Inazawa J. Clinical and radiological features of Japanese patients with a severe phenotype due to CASK mutations. Am J Med Genet A. 2012 Dec; 158A(12):3112-8. PMID: 23165780.
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      52. González G, Vedolin L, Barry B, Poduri A, Walsh C, Barkovich AJ. Location of periventricular nodular heterotopia is related to the malformation phenotype on MRI. AJNR Am J Neuroradiol. 2013 Apr; 34(4):877-83. PMID: 23064591; PMCID: PMC3951137.
      53. Gupta N, Henry RG, Strober J, Kang SM, Lim DA, Bucci M, Caverzasi E, Gaetano L, Mandelli ML, Ryan T, Perry R, Farrell J, Jeremy RJ, Ulman M, Huhn SL, Barkovich AJ, Rowitch DH. Neural stem cell engraftment and myelination in the human brain. Sci Transl Med. 2012 Oct 10; 4(155):155ra137. PMID: 23052294; PMCID: PMC3893824.
      54. Burger IM, Filly RA, Bowie J, Barkovich AJ. The grand unifying theory of bright echoes in the fetal and neonatal brain. J Ultrasound Med. 2012 Oct; 31(10):1665-73. PMID: 23011630.
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      55. Mochida GH, Ganesh VS, de Michelena MI, Dias H, Atabay KD, Kathrein KL, Huang HT, Hill RS, Felie JM, Rakiec D, Gleason D, Hill AD, Malik AN, Barry BJ, Partlow JN, Tan WH, Glader LJ, Barkovich AJ, Dobyns WB, Zon LI, Walsh CA. CHMP1A encodes an essential regulator of BMI1-INK4A in cerebellar development. Nat Genet. 2012 Nov; 44(11):1260-4. PMID: 23023333; PMCID: PMC3567443.
      56. Scott JA, Hamzelou KS, Rajagopalan V, Habas PA, Kim K, Barkovich AJ, Glenn OA, Studholme C. 3D morphometric analysis of human fetal cerebellar development. Cerebellum. 2012 Sep; 11(3):761-70. PMID: 22198870; PMCID: PMC3389138.
      57. Pisano T, Barkovich AJ, Leventer RJ, Squier W, Scheffer IE, Parrini E, Blaser S, Marini C, Robertson S, Tortorella G, Rosenow F, Thomas P, McGillivray G, Andermann E, Andermann F, Berkovic SF, Dobyns WB, Guerrini R. Peritrigonal and temporo-occipital heterotopia with corpus callosum and cerebellar dysgenesis. Neurology. 2012 Sep 18; 79(12):1244-51. PMID: 22914838; PMCID: PMC3440449.
      58. Hinkley LB, Marco EJ, Findlay AM, Honma S, Jeremy RJ, Strominger Z, Bukshpun P, Wakahiro M, Brown WS, Paul LK, Barkovich AJ, Mukherjee P, Nagarajan SS, Sherr EH. The role of corpus callosum development in functional connectivity and cognitive processing. PLoS One. 2012; 7(8):e39804. PMID: 22870191; PMCID: PMC3411722.
      59. Zaki MS, Saleem SN, Dobyns WB, Barkovich AJ, Bartsch H, Dale AM, Ashtari M, Akizu N, Gleeson JG, Grijalvo-Perez AM. Diencephalic-mesencephalic junction dysplasia: a novel recessive brain malformation. Brain. 2012 Aug; 135(Pt 8):2416-27. PMID: 22822038; PMCID: PMC3407423.
      60. Tangtiphaiboontana J, Hess CP, Bayer M, Drolet BA, Nassif LM, Metry DW, Barkovich AJ, Frieden IJ, Fullerton HJ. Neurodevelopmental abnormalities in children with PHACE syndrome. J Child Neurol. 2013 May; 28(5):608-14. PMID: 22805249.
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      61. Cellini E, Disciglio V, Novara F, Barkovich JA, Mencarelli MA, Hayek J, Renieri A, Zuffardi O, Guerrini R. Periventricular heterotopia with white matter abnormalities associated with 6p25 deletion. Am J Med Genet A. 2012 Jul; 158A(7):1793-7. PMID: 22678982.
        View in: PubMed
      62. Bonifacio SL, Saporta A, Glass HC, Lee P, Glidden DV, Ferriero DM, Barkovich AJ, Xu D. Therapeutic hypothermia for neonatal encephalopathy results in improved microstructure and metabolism in the deep gray nuclei. AJNR Am J Neuroradiol. 2012 Dec; 33(11):2050-5. PMID: 22595900; PMCID: PMC3473161.
      63. Vedolin L, Gonzalez G, Souza CF, Lourenço C, Barkovich AJ. Inherited cerebellar ataxia in childhood: a pattern-recognition approach using brain MRI. AJNR Am J Neuroradiol. 2013 May; 34(5):925-34, S1-2. PMID: 22595899.
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      64. Scott JA, Habas PA, Rajagopalan V, Kim K, Barkovich AJ, Glenn OA, Studholme C. Volumetric and surface-based 3D MRI analyses of fetal isolated mild ventriculomegaly: brain morphometry in ventriculomegaly. Brain Struct Funct. 2013 May; 218(3):645-55. PMID: 22547094.
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      65. Poduri A, Evrony GD, Cai X, Elhosary PC, Beroukhim R, Lehtinen MK, Hills LB, Heinzen EL, Hill A, Hill RS, Barry BJ, Bourgeois BF, Riviello JJ, Barkovich AJ, Black PM, Ligon KL, Walsh CA. Somatic activation of AKT3 causes hemispheric developmental brain malformations. Neuron. 2012 Apr 12; 74(1):41-8. PMID: 22500628; PMCID: PMC3460551.
      66. Glenn OA, Cuneo AA, Barkovich AJ, Hashemi Z, Bartha AI, Xu D. Malformations of cortical development: diagnostic accuracy of fetal MR imaging. Radiology. 2012 Jun; 263(3):843-55. PMID: 22495681; PMCID: PMC3359515.
      67. Okumura A, Lee T, Ikeno M, Shimojima K, Kajino K, Inoue Y, Yoshikawa N, Suganuma H, Suzuki M, Hisata K, Shoji H, Takanashi J, Barkovich AJ, Shimizu T, Yamamoto T, Hayashi M. A severe form of epidermal nevus syndrome associated with brainstem and cerebellar malformations and neonatal medulloblastoma. Brain Dev. 2012 Nov; 34(10):881-5. PMID: 22483529.
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      68. Rajagopalan V, Scott J, Habas PA, Kim K, Rousseau F, Glenn OA, Barkovich AJ, Studholme C. Mapping directionality specific volume changes using tensor based morphometry: an application to the study of gyrogenesis and lateralization of the human fetal brain. Neuroimage. 2012 Nov 1; 63(2):947-58. PMID: 22503938; PMCID: PMC3732053.
      69. Barkovich AJ, Guerrini R, Kuzniecky RI, Jackson GD, Dobyns WB. A developmental and genetic classification for malformations of cortical development: update 2012. Brain. 2012 May; 135(Pt 5):1348-69. PMID: 22427329; PMCID: PMC3338922.
      70. Takanashi J, Takahashi Y, Imamura A, Kodama K, Watanabe A, Tominaga K, Muramatsu K, Barkovich AJ. Late delirious behavior with 2009 H1N1 influenza: mild autoimmune-mediated encephalitis? Pediatrics. 2012 Apr; 129(4):e1068-71. PMID: 22412029.
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      71. Tymofiyeva O, Hess CP, Ziv E, Tian N, Bonifacio SL, McQuillen PS, Ferriero DM, Barkovich AJ, Xu D. Towards the "baby connectome": mapping the structural connectivity of the newborn brain. PLoS One. 2012; 7(2):e31029. PMID: 22347423; PMCID: PMC3274551.
      72. Tam EW, Haeusslein LA, Bonifacio SL, Glass HC, Rogers EE, Jeremy RJ, Barkovich AJ, Ferriero DM. Hypoglycemia is associated with increased risk for brain injury and adverse neurodevelopmental outcome in neonates at risk for encephalopathy. J Pediatr. 2012 Jul; 161(1):88-93. PMID: 22306045; PMCID: PMC3346850.
      73. Takanashi J, Saito S, Aoki I, Barkovich AJ, Ito Y, Inoue K. Increased N-acetylaspartate in model mouse of Pelizaeus-Merzbacher disease. J Magn Reson Imaging. 2012 Feb; 35(2):418-25. PMID: 22379616.
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      74. Ndika JD, Johnston K, Barkovich JA, Wirt MD, O'Neill P, Betsalel OT, Jakobs C, Salomons GS. Developmental progress and creatine restoration upon long-term creatine supplementation of a patient with arginine:glycine amidinotransferase deficiency. Mol Genet Metab. 2012 May; 106(1):48-54. PMID: 22386973.
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      75. Barkovich AJ. Developmental disorders of the midbrain and hindbrain. Front Neuroanat. 2012 Jan 7; 6:7. PMID: 22408608; PMCID: PMC3294267.
      76. Glass HC, Hong KJ, Rogers EE, Jeremy RJ, Bonifacio SL, Sullivan JE, Barkovich AJ, Ferriero DM. Risk factors for epilepsy in children with neonatal encephalopathy. Pediatr Res. 2011 Nov; 70(5):535-40. PMID: 21796017; PMCID: PMC3189270.
      77. Tam EW, Chau V, Ferriero DM, Barkovich AJ, Poskitt KJ, Studholme C, Fok ED, Grunau RE, Glidden DV, Miller SP. Preterm cerebellar growth impairment after postnatal exposure to glucocorticoids. Sci Transl Med. 2011 Oct 19; 3(105):105ra105. PMID: 22013125; PMCID: PMC3682111.
      78. Takanashi J, Somazawa F, Maruyama K, Terada H, Xu D, Barkovich AJ. Metabolic changes in early childhood using LCModel with corrected water scaling method. J Magn Reson Imaging. 2012 Jan; 35(1):174-80. PMID: 21960437.
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      79. Cabrera MT, Winn BJ, Porco T, Strominger Z, Barkovich AJ, Hoyt CS, Wakahiro M, Sherr EH. Laterality of brain and ocular lesions in Aicardi syndrome. Pediatr Neurol. 2011 Sep; 45(3):149-54. PMID: 21824560; PMCID: PMC3153732.
      80. Glass HC, Nash KB, Bonifacio SL, Barkovich AJ, Ferriero DM, Sullivan JE, Cilio MR. Seizures and magnetic resonance imaging-detected brain injury in newborns cooled for hypoxic-ischemic encephalopathy. J Pediatr. 2011 Nov; 159(5):731-735.e1. PMID: 21839470; PMCID: PMC3193544.
      81. Chang EF, Wang DD, Barkovich AJ, Tihan T, Auguste KI, Sullivan JE, Garcia PA, Barbaro NM. Predictors of seizure freedom after surgery for malformations of cortical development. Ann Neurol. 2011 Jul; 70(1):151-62. PMID: 21761443.
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      82. Harbert MJ, Tam EW, Glass HC, Bonifacio SL, Haeusslein LA, Barkovich AJ, Jeremy RJ, Rogers EE, Glidden DV, Ferriero DM. Hypothermia is correlated with seizure absence in perinatal stroke. J Child Neurol. 2011 Sep; 26(9):1126-30. PMID: 21700899; PMCID: PMC3594994.
      83. Fullerton HJ, Elkind MS, Barkovich AJ, Glaser C, Glidden D, Hills NK, Leiva-Salinas C, Wintermark M, Deveber GA. The vascular effects of infection in Pediatric Stroke (VIPS) Study. J Child Neurol. 2011 Sep; 26(9):1101-10. PMID: 21616922; PMCID: PMC3397827.
      84. Habas PA, Scott JA, Roosta A, Rajagopalan V, Kim K, Rousseau F, Barkovich AJ, Glenn OA, Studholme C. Early folding patterns and asymmetries of the normal human brain detected from in utero MRI. Cereb Cortex. 2012 Jan; 22(1):13-25. PMID: 21571694; PMCID: PMC3236791.
      85. Glass HC, Bowman C, Chau V, Moosa A, Hersh AL, Campbell A, Poskitt K, Azakie A, Barkovich AJ, Miller SP, McQuillen PS. Infection and white matter injury in infants with congenital cardiac disease. Cardiol Young. 2011 Oct; 21(5):562-71. PMID: 21554828; PMCID: PMC3171591.
      86. Kim K, Habas PA, Rajagopalan V, Scott JA, Corbett-Detig JM, Rousseau F, Barkovich AJ, Glenn OA, Studholme C. Bias field inconsistency correction of motion-scattered multislice MRI for improved 3D image reconstruction. IEEE Trans Med Imaging. 2011 Sep; 30(9):1704-12. PMID: 21511561; PMCID: PMC3318956.
      87. Scott JA, Habas PA, Kim K, Rajagopalan V, Hamzelou KS, Corbett-Detig JM, Barkovich AJ, Glenn OA, Studholme C. Growth trajectories of the human fetal brain tissues estimated from 3D reconstructed in utero MRI. Int J Dev Neurosci. 2011 Aug; 29(5):529-36. PMID: 21530634; PMCID: PMC3315847.
      88. Encinas JL, García-Cabezas MÁ, Barkovich J, Fontecha CG, Peiró JL, Soto GM, Borrell V, Reillo I, López-Santamaría M, Tovar JA, Farmer DL. Maldevelopment of the cerebral cortex in the surgically induced model of myelomeningocele: implications for fetal neurosurgery. J Pediatr Surg. 2011 Apr; 46(4):713-22. PMID: 21496543.
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      89. Adachi Y, Poduri A, Kawaguch A, Yoon G, Salih MA, Yamashita F, Walsh CA, Barkovich AJ. Congenital microcephaly with a simplified gyral pattern: associated findings and their significance. AJNR Am J Neuroradiol. 2011 Jun-Jul; 32(6):1123-9. PMID: 21454410; PMCID: PMC3838394.
      90. Rajagopalan V, Scott J, Habas PA, Kim K, Corbett-Detig J, Rousseau F, Barkovich AJ, Glenn OA, Studholme C. Local tissue growth patterns underlying normal fetal human brain gyrification quantified in utero. J Neurosci. 2011 Feb 23; 31(8):2878-87. PMID: 21414909; PMCID: PMC3093305.
      91. Nash KB, Bonifacio SL, Glass HC, Sullivan JE, Barkovich AJ, Ferriero DM, Cilio MR. Video-EEG monitoring in newborns with hypoxic-ischemic encephalopathy treated with hypothermia. Neurology. 2011 Feb 8; 76(6):556-62. PMID: 21300971; PMCID: PMC3053178.
      92. Xu D, Bonifacio SL, Charlton NN, P Vaughan C, Lu Y, Ferriero DM, Vigneron DB, Barkovich AJ. MR spectroscopy of normative premature newborns. J Magn Reson Imaging. 2011 Feb; 33(2):306-11. PMID: 21274971; PMCID: PMC3391540.
      93. Rajagopalan V, Scott J, Habas PA, Kim K, Rousseau F, Glenn OA, Barkovich AJ, Studholme C. Spatiotemporal morphometry of adjacent tissue layers with application to the study of sulcal formation. Med Image Comput Comput Assist Interv. 2011; 14(Pt 2):476-83. PMID: 21995063; PMCID: PMC3682114.
      94. Mochida GH, Ganesh VS, Felie JM, Gleason D, Hill RS, Clapham KR, Rakiec D, Tan WH, Akawi N, Al-Saffar M, Partlow JN, Tinschert S, Barkovich AJ, Ali B, Al-Gazali L, Walsh CA. A homozygous mutation in the tight-junction protein JAM3 causes hemorrhagic destruction of the brain, subependymal calcification, and congenital cataracts. Am J Hum Genet. 2010 Dec 10; 87(6):882-9. PMID: 21109224; PMCID: PMC2997371.
      95. Blümcke I, Thom M, Aronica E, Armstrong DD, Vinters HV, Palmini A, Jacques TS, Avanzini G, Barkovich AJ, Battaglia G, Becker A, Cepeda C, Cendes F, Colombo N, Crino P, Cross JH, Delalande O, Dubeau F, Duncan J, Guerrini R, Kahane P, Mathern G, Najm I, Ozkara C, Raybaud C, Represa A, Roper SN, Salamon N, Schulze-Bonhage A, Tassi L, Vezzani A, Spreafico R. The clinicopathologic spectrum of focal cortical dysplasias: a consensus classification proposed by an ad hoc Task Force of the ILAE Diagnostic Methods Commission. Epilepsia. 2011 Jan; 52(1):158-74. PMID: 21219302; PMCID: PMC3058866.
      96. Hess CP, Barkovich AJ. Seizures: emergency neuroimaging. Neuroimaging Clin N Am. 2010 Nov; 20(4):619-37. PMID: 20974379.
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      97. Corbett-Detig J, Habas PA, Scott JA, Kim K, Rajagopalan V, McQuillen PS, Barkovich AJ, Glenn OA, Studholme C. 3D global and regional patterns of human fetal subplate growth determined in utero. Brain Struct Funct. 2011 Jan; 215(3-4):255-63. PMID: 21046152; PMCID: PMC3041913.
      98. Barkovich J, Hevner RF. Meningeal gyrations. Ann Neurol. 2010 Oct; 68(4):421-3. PMID: 20865763.
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      99. Kim K, Habas P, Rajagopalan V, Scott J, Corbett-Detig J, Rousseau F, Glenn O, Barkovich J, Studholme C. Non-iterative relative bias correction for 3D reconstruction of in utero fetal brain MR imaging. Conf Proc IEEE Eng Med Biol Soc. 2010; 2010:879-82. PMID: 21097200.
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