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Geoffrey Manley, MD, PhD

TitleProfessor
SchoolUCSF School of Medicine
DepartmentNeurological Surgery
Address185 Berry Street Bldg B
San Francisco CA 94158
Phone415-206-8300
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    Collapse Research 
    Collapse Research Activities and Funding
    Transforming Research and Clinical Knowledge in Traumatic Brain Injury
    NIH/NINDS U01NS086090Sep 30, 2013 - Aug 31, 2018
    Role: Principal Investigator
    Transforming Traumatic Brain Injury Research and Clinical Care
    NIH/NINDS RC2NS069409Sep 30, 2009 - Aug 31, 2013
    Role: Principal Investigator
    Role of Aquaporin-4 Water Channels in Cerebral Edema
    NIH/NINDS R01NS050173May 25, 2005 - Apr 30, 2010
    Role: Principal Investigator
    Vascular Biomechanics in Traumatic Brain Injury
    CDC/NCIPC R49CE000460Sep 1, 2004 - Aug 31, 2008
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse Global Health

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Nielson JL, Cooper SR, Yue JK, Sorani MD, Inoue T, Yuh EL, Mukherjee P, Petrossian TC, Paquette J, Lum PY, Carlsson GE, Vassar MJ, Lingsma HF, Gordon WA, Valadka AB, Okonkwo DO, Manley G, Ferguson AR. Uncovering precision phenotype-biomarker associations in traumatic brain injury using topological data analysis. PLoS One. 2017; 12(3):e0169490. PMID: 28257413.
      View in: PubMed
    2. Haefeli J, Mabray MC, Whetstone WD, Dhall SS, Pan JZ, Upadhyayula P, Manley GT, Bresnahan JC, Beattie MS, Ferguson AR, Talbott JF. Multivariate Analysis of MRI Biomarkers for Predicting Neurologic Impairment in Cervical Spinal Cord Injury. AJNR Am J Neuroradiol. 2016 Dec 22. PMID: 28007771.
      View in: PubMed
    3. Manley GA. The mammalian Cretaceous cochlear revolution. Hear Res. 2016 Dec 19. PMID: 28007525.
      View in: PubMed
    4. Yue JK, Winkler EA, Rick JW, Burke JF, McAllister TW, Oh SS, Burchard EG, Hu D, Rosand J, Temkin NR, Korley FK, Sorani MD, Ferguson AR, Lingsma HF, Sharma S, Robinson CK, Yuh EL, Tarapore PE, Wang KK, Puccio AM, Mukherjee P, Diaz-Arrastia R, Gordon WA, Valadka AB, Okonkwo DO, Manley GT. DRD2 C957T polymorphism is associated with improved 6-month verbal learning following traumatic brain injury. Neurogenetics. 2016 Nov 8. PMID: 27826691.
      View in: PubMed
    5. Readdy WJ, Saigal R, Whetstone WD, Mefford AN, Ferguson AR, Talbott JF, Inoue T, Bresnahan JC, Beattie MS, Pan J, Manley GT, Dhall SS. Failure of Mean Arterial Pressure Goals to Improve Outcomes Following Penetrating Spinal Cord Injury. Neurosurgery. 2016 Nov; 79(5):708-714. PMID: 27759678.
      View in: PubMed
    6. Winkler EA, Yue JK, Ferguson AR, Temkin NR, Stein MB, Barber J, Yuh EL, Sharma S, Satris GG, McAllister TW, Rosand J, Sorani MD, Lingsma HF, Tarapore PE, Burchard EG, Hu D, Eng C, Wang KK, Mukherjee P, Okonkwo DO, Diaz-Arrastia R, Manley GT. COMT Val(158)Met polymorphism is associated with post-traumatic stress disorder and functional outcome following mild traumatic brain injury. J Clin Neurosci. 2016 Oct 18. PMID: 27769642.
      View in: PubMed
    7. Winkler EA, Minter D, Yue JK, Manley GT. Cerebral Edema in Traumatic Brain Injury: Pathophysiology and Prospective Therapeutic Targets. Neurosurg Clin N Am. 2016 Oct; 27(4):473-88. PMID: 27637397.
      View in: PubMed
    8. Vespa PM, Hirt D, Manley GT. Advances in Neurotrauma Research. Neurosurg Clin N Am. 2016 Oct; 27(4):xv-xvi. PMID: 27637404.
      View in: PubMed
    9. Catapano JS, John Hawryluk GW, Whetstone W, Saigal R, Ferguson A, Talbott J, Bresnahan J, Dhall S, Pan J, Beattie M, Manley G, et al. Higher Mean Arterial Pressure Values Correlate With Neurological Improvement in Patients With Initially Complete Spinal Cord Injuries. World Neurosurg. 2016 Aug 23. PMID: 27565460.
      View in: PubMed
    10. Manley GA. Comparative Auditory Neuroscience: Understanding the Evolution and Function of Ears. J Assoc Res Otolaryngol. 2017 Feb; 18(1):1-24. PMID: 27539715.
      View in: PubMed
    11. Burke JF, Yue JK, Ngwenya LB, Winkler EA, Talbott J, Pan J, Ferguson A, Beattie M, Bresnahan J, Haefeli J, Whetstone W, Suen C, Huang MC, Manley G, Tarapore PE, Dhall SS. 182 Ultra-Early (<12 Hours) Decompression Improves Recovery After Spinal Cord Injury Compared to Early (12-24 Hours) Decompression. Neurosurgery. 2016 Aug; 63 Suppl 1:172. PMID: 27399461.
      View in: PubMed
    12. Winkler EA, Yue JK, Burke JF, Mummaneni PV, Manley GT, Tarapore PE, Dhall SS. 188 Morbidity and Mortality Associated With Operative Management of Traumatic C2 Fractures in Octogenarians. Neurosurgery. 2016 Aug; 63 Suppl 1:174-5. PMID: 27399467.
      View in: PubMed
    13. Ngwenya LB, Burke JF, Manley GT. Brain Tissue Oxygen Monitoring and the Intersection of Brain and Lung: A Comprehensive Review. Respir Care. 2016 Sep; 61(9):1232-44. PMID: 27435860.
      View in: PubMed
    14. Silverberg ND, Crane PK, Dams-O'Connor K, Holdnack J, Ivins BJ, Lange RT, Manley GT, McCrea M, Iverson GL. Developing a Cognition Endpoint for Traumatic Brain Injury Clinical Trials. J Neurotrauma. 2016 Jun 27. PMID: 27188248.
      View in: PubMed
    15. Haarbauer-Krupa J, Taylor CA, Yue JK, Winkler EA, Pirracchio R, Cooper SR, Burke JF, Stein MB, Manley GT. Screening for Post-Traumatic Stress Disorder in a Civilian Emergency Department Population with Traumatic Brain Injury. J Neurotrauma. 2017 Jan 01; 34(1):50-58. PMID: 26936513.
      View in: PubMed
    16. Hendrickson CM, Howard BM, Kornblith LZ, Conroy AS, Nelson MF, Zhuo H, Liu KD, Manley GT, Matthay MA, Calfee CS, Cohen MJ. The acute respiratory distress syndrome following isolated severe traumatic brain injury. J Trauma Acute Care Surg. 2016 Jun; 80(6):989-97. PMID: 26881489.
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    17. Readdy WJ, Saigal R, Whetstone WD, Mefford A, Ferguson AR, Talbott JF, Inoue T, Bresnahan JC, Beattie MS, Pan J, Manley G, Dhall SS. Failure of Mean Arterial Pressure Goals to Improve Outcomes Following Penetrating Spinal Cord Injury. Neurosurgery. 2016 May 3. PMID: 27145343.
      View in: PubMed
    18. Tarapore PE, Vassar MJ, Cooper S, Lay T, Galletly J, Manley G, Huang MC. Establishing a Traumatic Brain Injury Program of Care: Benchmarking Outcomes after Institutional Adoption of Evidence-Based Guidelines. J Neurotrauma. 2016 Apr 29. PMID: 26917004.
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    19. Manley GA, van Dijk P. Frequency selectivity of the human cochlea: Suppression tuning of spontaneous otoacoustic emissions. Hear Res. 2016 Jun; 336:53-62. PMID: 27139323.
      View in: PubMed
    20. Lee S, Mattingly A, Lin A, Sacramento J, Mannent L, Castel MN, Canolle B, Delbary-Gossart S, Ferzaz B, Morganti JM, Rosi S, Ferguson AR, Manley GT, Bresnahan JC, Beattie MS. A novel antagonist of p75NTR reduces peripheral expansion and CNS trafficking of pro-inflammatory monocytes and spares function after traumatic brain injury. J Neuroinflammation. 2016; 13(1):88. PMID: 27102880.
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    21. Winkler EA, Yue JK, Burke JF, Chan AK, Dhall SS, Berger MS, Manley GT, Tarapore PE. Adult sports-related traumatic brain injury in United States trauma centers. Neurosurg Focus. 2016 Apr; 40(4):E4. PMID: 27032921.
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    22. Yue JK, Winkler EA, Burke JF, Chan AK, Dhall SS, Berger MS, Manley GT, Tarapore PE. Pediatric sports-related traumatic brain injury in United States trauma centers. Neurosurg Focus. 2016 Apr; 40(4):E3. PMID: 27032920.
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    23. Hawryluk GW, Phan N, Ferguson AR, Morabito D, Derugin N, Stewart CL, Knudson MM, Manley G, Rosenthal G. Brain tissue oxygen tension and its response to physiological manipulations: influence of distance from injury site in a swine model of traumatic brain injury. J Neurosurg. 2016 Nov; 125(5):1217-1228. PMID: 26848909.
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    24. Mabray MC, Talbott JF, Whetstone WD, Dhall SS, Phillips DB, Pan JZ, Manley G, Bresnahan JC, Beattie MS, Haefeli J, Ferguson AR. Multidimensional Analysis of Magnetic Resonance Imaging Predicts Early Impairment in Thoracic and Thoracolumbar Spinal Cord Injury. J Neurotrauma. 2016 May 15; 33(10):954-62. PMID: 26414451.
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    25. Wang KK, Yang Z, Yue JK, Zhang Z, Winkler EA, Puccio A, Diaz-Arrastia R, Lingsma H, Yuh EL, Mukherjee P, Valadka A, Gordon WA, Okonkwo DO, Manley G. Plasma Anti-Glial Fibrillary Acidic Protein Autoantibody Levels during the Acute and Chronic Phases of Traumatic Brain Injury: A Transforming Research and Clinical Knowledge in Traumatic Brain Injury Pilot Study. J Neurotrauma. 2016 Jul 1; 33(13):1270-7. PMID: 26560343.
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    26. Winkler EA, Yue JK, McAllister TW, Temkin NR, Oh SS, Burchard EG, Hu D, Ferguson AR, Lingsma HF, Burke JF, Sorani MD, Rosand J, Yuh EL, Barber J, Tarapore PE, Gardner RC, Sharma S, Satris GG, Eng C, Puccio AM, Wang KK, Mukherjee P, Valadka AB, Okonkwo DO, Diaz-Arrastia R, Manley G. COMT Val (158) Met polymorphism is associated with nonverbal cognition following mild traumatic brain injury. Neurogenetics. 2016 Jan; 17(1):31-41. PMID: 26576546.
      View in: PubMed
    27. Nielson JL, Paquette J, Liu AW, Guandique CF, Tovar CA, Inoue T, Irvine KA, Gensel JC, Kloke J, Petrossian TC, Lum PY, Carlsson GE, Manley GT, Young W, Beattie MS, Bresnahan JC, Ferguson AR. Topological data analysis for discovery in preclinical spinal cord injury and traumatic brain injury. Nat Commun. 2015; 6:8581. PMID: 26466022; PMCID: PMC4634208.
    28. Winkler EA, Yue JK, Birk H, Robinson CK, Manley GT, Dhall SS, Tarapore PE. Perioperative morbidity and mortality after lumbar trauma in the elderly. Neurosurg Focus. 2015 Oct; 39(4):E2. PMID: 26424342.
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    29. Amyot F, Arciniegas DB, Brazaitis MP, Curley KC, Diaz-Arrastia R, Gandjbakhche A, Herscovitch P, Hinds SR, Manley GT, Pacifico A, Razumovsky A, Riley J, Salzer W, Shih R, Smirniotopoulos JG, Stocker D. A Review of the Effectiveness of Neuroimaging Modalities for the Detection of Traumatic Brain Injury. J Neurotrauma. 2015 Nov 15; 32(22):1693-721. PMID: 26176603; PMCID: PMC4651019 [Available on 11/15/16].
    30. Korley FK, Diaz-Arrastia R, Wu AH, Yue JK, Manley G, Sair HI, Van Eyk J, Everett AD, Okonkwo DO, Valadka AB, Gordon WA, Maas AI, Mukherjee P, Yuh EL, Lingsma HF, Puccio AM, Schnyer DM. Circulating Brain-Derived Neurotrophic Factor Has Diagnostic and Prognostic Value in Traumatic Brain Injury. J Neurotrauma. 2016 Jan 15; 33(2):215-25. PMID: 26159676.
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    31. Hawryluk GW, Whetstone WD, Saigal R, Ferguson AR, Talbott JF, Bresnahan JC, Dhall SS, Pan JZ, Beattie MS, Manley G. Mean Arterial Blood Pressure Correlates with Neurological Recovery after Human Spinal Cord Injury: Analysis of High Frequency Physiologic Data. J Neurotrauma. 2015 Dec 15; 32(24):1958-67. PMID: 25669633.
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    32. Readdy WJ, Whetstone WD, Ferguson AR, Talbott JF, Inoue T, Saigal R, Bresnahan JC, Beattie MS, Pan JZ, Manley G, Dhall SS. Complications and outcomes of vasopressor usage in acute traumatic central cord syndrome. J Neurosurg Spine. 2015 Jul 31; 1-7. PMID: 26230417.
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    33. Talbott JF, Whetstone WD, Readdy WJ, Ferguson AR, Bresnahan JC, Saigal R, Hawryluk GW, Beattie MS, Mabray MC, Pan JZ, Manley GT, Dhall SS. The Brain and Spinal Injury Center score: a novel, simple, and reproducible method for assessing the severity of acute cervical spinal cord injury with axial T2-weighted MRI findings. J Neurosurg Spine. 2015 Oct; 23(4):495-504. PMID: 26161519.
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    34. Yao X, Uchida K, Papadopoulos MC, Zador Z, Manley GT, Verkman AS. Mildly Reduced Brain Swelling and Improved Neurological Outcome in Aquaporin-4 Knockout Mice following Controlled Cortical Impact Brain Injury. J Neurotrauma. 2015 Oct 1; 32(19):1458-64. PMID: 25790314; PMCID: PMC4589265 [Available on 10/01/16].
    35. Yao X, Smith AJ, Jin BJ, Zador Z, Manley GT, Verkman AS. Aquaporin-4 regulates the velocity and frequency of cortical spreading depression in mice. Glia. 2015 Oct; 63(10):1860-9. PMID: 25944186.
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    36. Yue JK, Pronger AM, Ferguson AR, Temkin NR, Sharma S, Rosand J, Sorani MD, McAllister TW, Barber J, Winkler EA, Burchard EG, Hu D, Lingsma HF, Cooper SR, Puccio AM, Okonkwo DO, Diaz-Arrastia R, Manley GT. Association of a common genetic variant within ANKK1 with six-month cognitive performance after traumatic brain injury. Neurogenetics. 2015 Jul; 16(3):169-80. PMID: 25633559.
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    37. McMahon PJ, Panczykowski DM, Yue JK, Puccio AM, Inoue T, Sorani MD, Lingsma HF, Maas AI, Valadka AB, Yuh EL, Mukherjee P, Manley GT, Okonkwo DO, Casey SS, Cheong M, Cooper SR, Dams-O'Connor K, Gordon WA, Hricik AJ, Lawless K, Menon D, Schnyer DM, Vassar MJ. Measurement of the glial fibrillary acidic protein and its breakdown products GFAP-BDP biomarker for the detection of traumatic brain injury compared to computed tomography and magnetic resonance imaging. J Neurotrauma. 2015 Apr 15; 32(8):527-33. PMID: 25264814; PMCID: PMC4394160 [Available on 04/15/16].
    38. Sorani MD, Yue JK, Sharma S, Manley GT, Ferguson AR, Cooper SR, Dams-O'Connor K, Gordon WA, Lingsma HF, Maas AI, Menon DK, Morabito DJ, Mukherjee P, Okonkwo DO, Puccio AM, Valadka AB, Yuh EL. Genetic data sharing and privacy. Neuroinformatics. 2015 Jan; 13(1):1-6. PMID: 25326433.
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    39. Maas AI, Menon DK, Steyerberg EW, Citerio G, Lecky F, Manley GT, Hill S, Legrand V, Sorgner A. Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI): a prospective longitudinal observational study. Neurosurgery. 2015 Jan; 76(1):67-80. PMID: 25525693.
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    40. Hawryluk GW, Manley GT. Classification of traumatic brain injury: past, present, and future. Handb Clin Neurol. 2015; 127:15-21. PMID: 25702207.
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    41. Wright DW, Yeatts SD, Silbergleit R, Palesch YY, Hertzberg VS, Frankel M, Goldstein FC, Caveney AF, Howlett-Smith H, Bengelink EM, Manley GT, Merck LH, Janis LS, Barsan WG. Very early administration of progesterone for acute traumatic brain injury. N Engl J Med. 2014 Dec 25; 371(26):2457-66. PMID: 25493974; PMCID: PMC4303469.
    42. Lingsma HF, Yue JK, Maas AI, Steyerberg EW, Manley GT, Cooper SR, Dams-O'Connor K, Gordon WA, Menon DK, Mukherjee P, Okonkwo DO, Puccio AM, Schnyer DM, Valadka AB, Vassar MJ, Yuh EL. Outcome prediction after mild and complicated mild traumatic brain injury: external validation of existing models and identification of new predictors using the TRACK-TBI pilot study. J Neurotrauma. 2015 Jan 15; 32(2):83-94. PMID: 25025611; PMCID: PMC4291219 [Available on 01/15/16].
    43. Rosenthal G, Ng I, Moscovici S, Lee KK, Lay T, Martin C, Manley GT. Polyetheretherketone implants for the repair of large cranial defects: a 3-center experience. Neurosurgery. 2014 Nov; 75(5):523-9; discussion 528-9. PMID: 24979096.
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    44. Yao X, Derugin N, Manley GT, Verkman AS. Reduced brain edema and infarct volume in aquaporin-4 deficient mice after transient focal cerebral ischemia. Neurosci Lett. 2015 Jan 1; 584:368-72. PMID: 25449874.
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    45. Yuh EL, Hawryluk GW, Manley GT. Imaging concussion: a review. Neurosurgery. 2014 Oct; 75 Suppl 4:S50-63. PMID: 25232884.
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    46. Yuh EL, Cooper SR, Mukherjee P, Yue JK, Lingsma HF, Gordon WA, Valadka AB, Okonkwo DO, Schnyer DM, Vassar MJ, Maas AI, Manley GT, Casey SS, Cheong M, Dams-O'Connor K, Hricik AJ, Inoue T, Menon DK, Morabito DJ, Pacheco JL, Puccio AM, Sinha TK. Diffusion tensor imaging for outcome prediction in mild traumatic brain injury: a TRACK-TBI study. J Neurotrauma. 2014 Sep 1; 31(17):1457-77. PMID: 24742275; PMCID: PMC4144386.
    47. Ratcliff JJ, Adeoye O, Lindsell CJ, Hart KW, Pancioli A, McMullan JT, Yue JK, Nishijima DK, Gordon WA, Valadka AB, Okonkwo DO, Lingsma HF, Maas AI, Manley GT. ED disposition of the Glasgow Coma Scale 13 to 15 traumatic brain injury patient: analysis of the Transforming Research and Clinical Knowledge in TBI study. Am J Emerg Med. 2014 Aug; 32(8):844-50. PMID: 24857248; PMCID: PMC4283794.
    48. Moore M, Winkelman A, Kwong S, Segal SP, Manley GT, Shumway M. The emergency department social work intervention for mild traumatic brain injury (SWIFT-Acute): a pilot study. Brain Inj. 2014; 28(4):448-55. PMID: 24702522.
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    49. Kolias AG, Hutchinson PJ, Menon DK, Manley GT, Gallagher CN, Servadei F. Decompressive craniectomy for acute subdural hematomas. J Neurosurg. 2014 May; 120(5):1247-9; author reply 1249. PMID: 24655100.
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    50. Sivaganesan A, Manley GT, Huang MC. Informatics for neurocritical care: challenges and opportunities. Neurocrit Care. 2014 Feb; 20(1):132-41. PMID: 23884510.
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    51. Inoue T, Manley GT, Patel N, Whetstone WD. Medical and surgical management after spinal cord injury: vasopressor usage, early surgerys, and complications. J Neurotrauma. 2014 Feb 1; 31(3):284-91. PMID: 24020382.
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    52. McMahon P, Hricik A, Yue JK, Puccio AM, Inoue T, Lingsma HF, Beers SR, Gordon WA, Valadka AB, Manley G, Okonkwo DO. Symptomatology and functional outcome in mild traumatic brain injury: results from the prospective TRACK-TBI study. J Neurotrauma. 2014 Jan 1; 31(1):26-33. PMID: 23952719; PMCID: PMC3880097.
    53. Dams-O'Connor K, Spielman L, Singh A, Gordon WA, Lingsma HF, Maas AI, Manley GT, Mukherjee P, Okonkwo DO, Puccio AM, Schnyer DM, Valadka AB, Yue JK, Yuh EL. The impact of previous traumatic brain injury on health and functioning: a TRACK-TBI study. J Neurotrauma. 2013 Dec 15; 30(24):2014-20. PMID: 23924069; PMCID: PMC3868372.
    54. Diaz-Arrastia R, Wang KK, Papa L, Sorani MD, Yue JK, Puccio AM, McMahon PJ, Inoue T, Yuh EL, Lingsma HF, Maas AI, Valadka AB, Okonkwo DO, Manley G. Acute biomarkers of traumatic brain injury: relationship between plasma levels of ubiquitin C-terminal hydrolase-L1 and glial fibrillary acidic protein. J Neurotrauma. 2014 Jan 1; 31(1):19-25. PMID: 23865516; PMCID: PMC3880090.
    55. Yue JK, Vassar MJ, Lingsma HF, Cooper SR, Okonkwo DO, Valadka AB, Gordon WA, Maas AI, Mukherjee P, Yuh EL, Puccio AM, Schnyer DM, Manley GT. Transforming research and clinical knowledge in traumatic brain injury pilot: multicenter implementation of the common data elements for traumatic brain injury. J Neurotrauma. 2013 Nov 15; 30(22):1831-44. PMID: 23815563; PMCID: PMC3814815.
    56. Manley GT, Maas AI. Traumatic brain injury: an international knowledge-based approach. JAMA. 2013 Aug 7; 310(5):473-4. PMID: 23925611.
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    57. Okonkwo DO, Yue JK, Puccio AM, Panczykowski DM, Inoue T, McMahon PJ, Sorani MD, Yuh EL, Lingsma HF, Maas AI, Valadka AB, Manley GT. GFAP-BDP as an acute diagnostic marker in traumatic brain injury: results from the prospective transforming research and clinical knowledge in traumatic brain injury study. J Neurotrauma. 2013 Sep 1; 30(17):1490-7. PMID: 23489259; PMCID: PMC3751263.
    58. Weiner MW, Friedl KE, Pacifico A, Chapman JC, Jaffee MS, Little DM, Manley GT, McKee A, Petersen RC, Pitman RK, Yaffe K, Zetterberg H, Obana R, Bain LJ, Carrillo MC. Military risk factors for Alzheimer's disease. Alzheimers Dement. 2013 Jul; 9(4):445-51. PMID: 23809365.
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    59. Inoue T, Lin A, Ma X, McKenna SL, Creasey GH, Manley GT, Ferguson AR, Bresnahan JC, Beattie MS. Combined SCI and TBI: recovery of forelimb function after unilateral cervical spinal cord injury (SCI) is retarded by contralateral traumatic brain injury (TBI), and ipsilateral TBI balances the effects of SCI on paw placement. Exp Neurol. 2013 Oct; 248:136-47. PMID: 23770071; PMCID: PMC4617760.
    60. Grossman AD, Cohen MJ, Manley GT, Butte AJ. Altering physiological networks using drugs: steps towards personalized physiology. BMC Med Genomics. 2013; 6 Suppl 2:S7. PMID: 23819503; PMCID: PMC3654899.
    61. Tarapore PE, Findlay AM, Lahue SC, Lee H, Honma SM, Mizuiri D, Luks TL, Manley GT, Nagarajan SS, Mukherjee P. Resting state magnetoencephalography functional connectivity in traumatic brain injury. J Neurosurg. 2013 Jun; 118(6):1306-16. PMID: 23600939; PMCID: PMC4071964.
    62. Manley GA. Mosaic evolution of the mammalian auditory periphery. Adv Exp Med Biol. 2013; 787:3-9. PMID: 23716203.
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    63. Yuh EL, Mukherjee P, Lingsma HF, Yue JK, Ferguson AR, Gordon WA, Valadka AB, Schnyer DM, Okonkwo DO, Maas AI, Manley GT. Magnetic resonance imaging improves 3-month outcome prediction in mild traumatic brain injury. Ann Neurol. 2013 Feb; 73(2):224-35. PMID: 23224915; PMCID: PMC4060890.
    64. Rosenfeld JV, Maas AI, Bragge P, Morganti-Kossmann MC, Manley GT, Gruen RL. Early management of severe traumatic brain injury. Lancet. 2012 Sep 22; 380(9847):1088-98. PMID: 22998718.
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    65. Moen KG, Skandsen T, Folvik M, Brezova V, Kvistad KA, Rydland J, Manley GT, Vik A. A longitudinal MRI study of traumatic axonal injury in patients with moderate and severe traumatic brain injury. J Neurol Neurosurg Psychiatry. 2012 Dec; 83(12):1193-200. PMID: 22933813.
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    66. Laroche M, Kutcher ME, Huang MC, Cohen MJ, Manley GT. Coagulopathy after traumatic brain injury. Neurosurgery. 2012 Jun; 70(6):1334-45. PMID: 22307074.
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    67. Yuh EL, Cooper SR, Ferguson AR, Manley GT. Quantitative CT improves outcome prediction in acute traumatic brain injury. J Neurotrauma. 2012 Mar 20; 29(5):735-46. PMID: 21970562; PMCID: PMC3303103.
    68. Lu DC, Zador Z, Yao J, Fazlollahi F, Manley GT. Aquaporin-4 Reduces Post-Traumatic Seizure Susceptibility by Promoting Astrocytic Glial Scar Formation in Mice. J Neurotrauma. 2011 09 22. PMID: 21939392.
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    69. Maas AI, Menon DK, Lingsma HF, Pineda JA, Sandel ME, Manley GT. Re-orientation of clinical research in traumatic brain injury: report of an international workshop on comparative effectiveness research. J Neurotrauma. 2012 Jan 1; 29(1):32-46. PMID: 21545277; PMCID: PMC3253305.
    70. Nakagawa K, Hills NK, Kamel H, Patel PV, Manley GT, Hemphill JC. The effect of decompressive hemicraniectomy on brain temperature after severe brain injury. Neurocrit Care. 2011 Aug; 15(1):101-6. PMID: 21061187; PMCID: PMC3627059.
    71. Sughrue ME, Bloch OG, Manley GT, Stiver SI. Marked reduction in wound complication rates following decompressive hemicraniectomy with an improved operative closure technique. J Clin Neurosci. 2011 Sep; 18(9):1201-5. PMID: 21752652.
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    72. Flint AC, Gean AD, Manley GT, Rao VA, Sheridan WF, von Koch CS. Temporizing treatment of hyperacute subdural hemorrhage by subdural evacuation port system placement. J Neurosurg. 2011 Oct; 115(4):844-8. PMID: 21682569.
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    73. Nakagawa A, Manley GT, Gean AD, Ohtani K, Armonda R, Tsukamoto A, Yamamoto H, Takayama K, Tominaga T. Mechanisms of primary blast-induced traumatic brain injury: insights from shock-wave research. J Neurotrauma. 2011 Jun; 28(6):1101-19. PMID: 21332411.
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    74. Beattie MS, Manley GT. Tight squeeze, slow burn: inflammation and the aetiology of cervical myelopathy. Brain. 2011 May; 134(Pt 5):1259-61. PMID: 21596766; PMCID: PMC3139947.
    75. Sorani MD, Manley GT, Claude Hemphill J, Baranzini SE. Dynamic, multi-level network models of clinical trials. Pac Symp Biocomput. 2011; 38-49. PMID: 21121031.
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    76. Whyte J, Vasterling J, Manley GT. Common data elements for research on traumatic brain injury and psychological health: current status and future development. Arch Phys Med Rehabil. 2010 Nov; 91(11):1692-6. PMID: 21044713.
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    77. Voytek B, Secundo L, Bidet-Caulet A, Scabini D, Stiver SI, Gean AD, Manley GT, Knight RT. Hemicraniectomy: a new model for human electrophysiology with high spatio-temporal resolution. J Cogn Neurosci. 2010 Nov; 22(11):2491-502. PMID: 19925193; PMCID: PMC2888789.
    78. Manley GT, Diaz-Arrastia R, Brophy M, Engel D, Goodman C, Gwinn K, Veenstra TD, Ling G, Ottens AK, Tortella F, Hayes RL. Common data elements for traumatic brain injury: recommendations from the biospecimens and biomarkers working group. Arch Phys Med Rehabil. 2010 Nov; 91(11):1667-72. PMID: 21044710.
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    80. Monson KL, Matsumoto MM, Young WL, Manley GT, Hashimoto T. Abrupt increase in rat carotid blood flow induces rapid alteration of artery mechanical properties. J Mech Behav Biomed Mater. 2011 Jan; 4(1):9-15. PMID: 21094476; PMCID: PMC3058727.
    81. Gean AD, Fischbein NJ, Purcell DD, Aiken AH, Manley GT, Stiver SI. Benign anterior temporal epidural hematoma: indolent lesion with a characteristic CT imaging appearance after blunt head trauma. Radiology. 2010 Oct; 257(1):212-8. PMID: 20713606.
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    82. Rosenthal G, Sanchez-Mejia RO, Phan N, Hemphill JC, Martin C, Manley GT. Incorporating a parenchymal thermal diffusion cerebral blood flow probe in bedside assessment of cerebral autoregulation and vasoreactivity in patients with severe traumatic brain injury. J Neurosurg. 2011 Jan; 114(1):62-70. PMID: 20707619.
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    83. Cohen MJ, Grossman AD, Morabito D, Knudson MM, Butte AJ, Manley GT. Identification of complex metabolic states in critically injured patients using bioinformatic cluster analysis. Crit Care. 2010; 14(1):R10. PMID: 20122274; PMCID: PMC2875524.
    84. Chun KA, Manley GT, Stiver SI, Aiken AH, Phan N, Wang V, Meeker M, Cheng SC, Gean AD, Wintermark M. Interobserver variability in the assessment of CT imaging features of traumatic brain injury. J Neurotrauma. 2010 Feb; 27(2):325-30. PMID: 19895192; PMCID: PMC2834438.
    85. Maas AI, Roozenbeek B, Manley GT. Clinical trials in traumatic brain injury: past experience and current developments. Neurotherapeutics. 2010 Jan; 7(1):115-26. PMID: 20129503.
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    86. Grossman AD, Cohen MJ, Manley GT, Butte AJ. Infection in the intensive care unit alters physiological networks. BMC Bioinformatics. 2009; 10 Suppl 9:S4. PMID: 19761574; PMCID: PMC2745691.
    87. Sorani MD, Lee M, Kim H, Meeker M, Manley GT. Race\ethnicity and outcome after traumatic brain injury at a single, diverse center. J Trauma. 2009 Jul; 67(1):75-80. PMID: 19590312.
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    88. Chou D, Eltgroth M, Yang I, Lu D, Manley G. Rib head disarticulation for multilevel transpedicular thoracic corpectomies and expandable cage reconstruction. Neurol India. 2009 Jul-Aug; 57(4):469-74. PMID: 19770550.
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    89. Stiver SI, Gean AD, Manley GT. Survival with good outcome after cerebral herniation and Duret hemorrhage caused by traumatic brain injury. J Neurosurg. 2009 Jun; 110(6):1242-6. PMID: 19012479.
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    90. Manley GT. Introduction: decompressive craniectomy for trauma and cerebrovascular disease. Neurosurg Focus. 2009 Jun; 26(6):E1. PMID: 19485713.
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    91. Sparrey CJ, Manley GT, Keaveny TM. Effects of white, grey, and pia mater properties on tissue level stresses and strains in the compressed spinal cord. J Neurotrauma. 2009 Apr; 26(4):585-95. PMID: 19292657; PMCID: PMC2877118.
    92. Wan JJ, Cohen MJ, Rosenthal G, Haitsma IK, Morabito DJ, Derugin N, Knudson MM, Manley GT. Refining resuscitation strategies using tissue oxygen and perfusion monitoring in critical organ beds. J Trauma. 2009 Feb; 66(2):353-7. PMID: 19204507.
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    93. Zador Z, Stiver S, Wang V, Manley GT. Role of aquaporin-4 in cerebral edema and stroke. Handb Exp Pharmacol. 2009; (190):159-70. PMID: 19096776; PMCID: PMC3516842.
    94. Stewart C, Haitsma I, Zador Z, Hemphill JC, Morabito D, Manley G, Rosenthal G. The new Licox combined brain tissue oxygen and brain temperature monitor: assessment of in vitro accuracy and clinical experience in severe traumatic brain injury. Neurosurgery. 2008 Dec; 63(6):1159-64; discussion 1164-5. PMID: 19057329.
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    95. Niogi SN, Mukherjee P, Ghajar J, Johnson CE, Kolster R, Lee H, Suh M, Zimmerman RD, Manley GT, McCandliss BD. Structural dissociation of attentional control and memory in adults with and without mild traumatic brain injury. Brain. 2008 Dec; 131(Pt 12):3209-21. PMID: 18952679.
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    96. Monson KL, Barbaro NM, Manley GT. Biaxial response of passive human cerebral arteries. Ann Biomed Eng. 2008 Dec; 36(12):2028-41. PMID: 18855141; PMCID: PMC2613334.
    97. Vik A, Nag T, Fredriksli OA, Skandsen T, Moen KG, Schirmer-Mikalsen K, Manley GT. Relationship of "dose" of intracranial hypertension to outcome in severe traumatic brain injury. J Neurosurg. 2008 Oct; 109(4):678-84. PMID: 18826355.
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    98. Yuh EL, Gean AD, Manley GT, Callen AL, Wintermark M. Computer-aided assessment of head computed tomography (CT) studies in patients with suspected traumatic brain injury. J Neurotrauma. 2008 Oct; 25(10):1163-72. PMID: 18986221.
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    99. Stiver SI, Manley GT. Prehospital management of traumatic brain injury. Neurosurg Focus. 2008 Oct; 25(4):E5. PMID: 18828703.
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    100. Lee H, Wintermark M, Gean AD, Ghajar J, Manley GT, Mukherjee P. Focal lesions in acute mild traumatic brain injury and neurocognitive outcome: CT versus 3T MRI. J Neurotrauma. 2008 Sep; 25(9):1049-56. PMID: 18707244.
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    101. Sorani MD, Manley GT, Giacomini KM. Genetic variation in human aquaporins and effects on phenotypes of water homeostasis. Hum Mutat. 2008 Sep; 29(9):1108-17. PMID: 18470935.
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    102. Stiver SI, Wintermark M, Manley GT. Reversible monoparesis following decompressive hemicraniectomy for traumatic brain injury. J Neurosurg. 2008 Aug; 109(2):245-54. PMID: 18671636.
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    103. Saatman KE, Duhaime AC, Bullock R, Maas AI, Valadka A, Manley GT. Classification of traumatic brain injury for targeted therapies. J Neurotrauma. 2008 Jul; 25(7):719-38. PMID: 18627252; PMCID: PMC2721779.
    104. Rosenthal G, Hemphill JC, Sorani M, Martin C, Morabito D, Obrist WD, Manley GT. Brain tissue oxygen tension is more indicative of oxygen diffusion than oxygen delivery and metabolism in patients with traumatic brain injury. Crit Care Med. 2008 Jun; 36(6):1917-24. PMID: 18496376.
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    105. Sorani MD, Zador Z, Hurowitz E, Yan D, Giacomini KM, Manley GT. Novel variants in human Aquaporin-4 reduce cellular water permeability. Hum Mol Genet. 2008 Aug 1; 17(15):2379-89. PMID: 18511455; PMCID: PMC2733814.
    106. Yao X, Hrabetová S, Nicholson C, Manley GT. Aquaporin-4-deficient mice have increased extracellular space without tortuosity change. J Neurosci. 2008 May 21; 28(21):5460-4. PMID: 18495879; PMCID: PMC2659334.
    107. Flint AC, Manley GT, Gean AD, Hemphill JC, Rosenthal G. Post-operative expansion of hemorrhagic contusions after unilateral decompressive hemicraniectomy in severe traumatic brain injury. J Neurotrauma. 2008 May; 25(5):503-12. PMID: 18346002.
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    108. Sorani MD, Morabito D, Rosenthal G, Giacomini KM, Manley GT. Characterizing the dose-response relationship between mannitol and intracranial pressure in traumatic brain injury patients using a high-frequency physiological data collection system. J Neurotrauma. 2008 Apr; 25(4):291-8. PMID: 18373479.
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    109. Lu DC, Binder DK, Chien B, Maisel A, Manley GT. Cerebral salt wasting and elevated brain natriuretic peptide levels after traumatic brain injury: 2 case reports. Surg Neurol. 2008 Mar; 69(3):226-9. PMID: 18325424.
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    110. Rosenthal G, Morabito D, Cohen M, Roeytenberg A, Derugin N, Panter SS, Knudson MM, Manley G. Use of hemoglobin-based oxygen-carrying solution-201 to improve resuscitation parameters and prevent secondary brain injury in a swine model of traumatic brain injury and hemorrhage: laboratory investigation. J Neurosurg. 2008 Mar; 108(3):575-87. PMID: 18312106.
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    111. Niogi SN, Mukherjee P, Ghajar J, Johnson C, Kolster RA, Sarkar R, Lee H, Meeker M, Zimmerman RD, Manley GT, McCandliss BD. Extent of microstructural white matter injury in postconcussive syndrome correlates with impaired cognitive reaction time: a 3T diffusion tensor imaging study of mild traumatic brain injury. AJNR Am J Neuroradiol. 2008 May; 29(5):967-73. PMID: 18272556.
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    112. Wang VY, Manley G. Recognition of paroxysmal autonomic instability with dystonia (PAID) in a patient with traumatic brain injury. J Trauma. 2008 Feb; 64(2):500-2. PMID: 18301221.
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    113. Haitsma I, Rosenthal G, Morabito D, Rollins M, Maas AI, Manley GT. In vitro comparison of two generations of Licox and Neurotrend catheters. Acta Neurochir Suppl. 2008; 102:197-202. PMID: 19388316.
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    114. Stiver SI, Wintermark M, Manley GT. Motor trephine syndrome: a mechanistic hypothesis. Acta Neurochir Suppl. 2008; 102:273-7. PMID: 19388328.
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    115. Potts MB, Chi JH, Meeker M, Holland MC, Claude HJ, Manley GT. Predictive values of age and the Glasgow Coma Scale in traumatic brain injury patients treated with decompressive craniectomy. Acta Neurochir Suppl. 2008; 102:109-12. PMID: 19388299.
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    116. Sorani MD, Manley GT. Dose-response relationship of mannitol and intracranial pressure: a metaanalysis. J Neurosurg. 2008 Jan; 108(1):80-7. PMID: 18173314.
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    117. Rosenthal G, Hemphill JC, Sorani M, Martin C, Morabito D, Meeker M, Wang V, Manley GT. The role of lung function in brain tissue oxygenation following traumatic brain injury. J Neurosurg. 2008 Jan; 108(1):59-65. PMID: 18173311.
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    118. Cohen MJ, Brohi K, Ganter MT, Manley GT, Mackersie RC, Pittet JF. Early coagulopathy after traumatic brain injury: the role of hypoperfusion and the protein C pathway. J Trauma. 2007 Dec; 63(6):1254-61; discussion 1261-2. PMID: 18212647.
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    119. Zador Z, Magzoub M, Jin S, Manley GT, Papadopoulos MC, Verkman AS. Microfiberoptic fluorescence photobleaching reveals size-dependent macromolecule diffusion in extracellular space deep in brain. FASEB J. 2008 Mar; 22(3):870-9. PMID: 17965267.
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    120. Smith JS, Chang EF, Rosenthal G, Meeker M, von Koch C, Manley GT, Holland MC. The role of early follow-up computed tomography imaging in the management of traumatic brain injury patients with intracranial hemorrhage. J Trauma. 2007 Jul; 63(1):75-82. PMID: 17622872.
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    121. Quiñones-Hinojosa A, Chi JH, Manley GT. Emergent placement of halo orthosis after a traumatic cervical injury leading to a cerebral abscess. J Trauma. 2007 Jun; 62(6):E11-3. PMID: 17563638.
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    122. Bloch O, Manley GT. The role of aquaporin-4 in cerebral water transport and edema. Neurosurg Focus. 2007; 22(5):E3. PMID: 17613234.
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    123. Bratton SL, Chestnut RM, Ghajar J, McConnell Hammond FF, Harris OA, Hartl R, Manley GT, Nemecek A, Newell DW, Rosenthal G, Schouten J, Shutter L, Timmons SD, Ullman JS, Videtta W, Wilberger JE, Wright DW. Guidelines for the management of severe traumatic brain injury. IX. Cerebral perfusion thresholds. J Neurotrauma. 2007; 24 Suppl 1:S59-64. PMID: 17511547.
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    124. Bratton SL, Chestnut RM, Ghajar J, McConnell Hammond FF, Harris OA, Hartl R, Manley GT, Nemecek A, Newell DW, Rosenthal G, Schouten J, Shutter L, Timmons SD, Ullman JS, Videtta W, Wilberger JE, Wright DW. Guidelines for the management of severe traumatic brain injury. VIII. Intracranial pressure thresholds. J Neurotrauma. 2007; 24 Suppl 1:S55-8. PMID: 17511546.
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    125. Bratton SL, Chestnut RM, Ghajar J, McConnell Hammond FF, Harris OA, Hartl R, Manley GT, Nemecek A, Newell DW, Rosenthal G, Schouten J, Shutter L, Timmons SD, Ullman JS, Videtta W, Wilberger JE, Wright DW. Guidelines for the management of severe traumatic brain injury. XII. Nutrition. J Neurotrauma. 2007; 24 Suppl 1:S77-82. PMID: 17511551.
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    126. Bratton SL, Chestnut RM, Ghajar J, McConnell Hammond FF, Harris OA, Hartl R, Manley GT, Nemecek A, Newell DW, Rosenthal G, Schouten J, Shutter L, Timmons SD, Ullman JS, Videtta W, Wilberger JE, Wright DW. Guidelines for the management of severe traumatic brain injury. III. Prophylactic hypothermia. J Neurotrauma. 2007; 24 Suppl 1:S21-5. PMID: 17511540.
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    127. Bratton SL, Chestnut RM, Ghajar J, McConnell Hammond FF, Harris OA, Hartl R, Manley GT, Nemecek A, Newell DW, Rosenthal G, Schouten J, Shutter L, Timmons SD, Ullman JS, Videtta W, Wilberger JE, Wright DW. Guidelines for the management of severe traumatic brain injury. XIV. Hyperventilation. J Neurotrauma. 2007; 24 Suppl 1:S87-90. PMID: 17511553.
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    128. Bratton SL, Chestnut RM, Ghajar J, McConnell Hammond FF, Harris OA, Hartl R, Manley GT, Nemecek A, Newell DW, Rosenthal G, Schouten J, Shutter L, Timmons SD, Ullman JS, Videtta W, Wilberger JE, Wright DW. Guidelines for the management of severe traumatic brain injury. I. Blood pressure and oxygenation. J Neurotrauma. 2007; 24 Suppl 1:S7-13. PMID: 17511549.
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    129. Bratton SL, Chestnut RM, Ghajar J, McConnell Hammond FF, Harris OA, Hartl R, Manley GT, Nemecek A, Newell DW, Rosenthal G, Schouten J, Shutter L, Timmons SD, Ullman JS, Videtta W, Wilberger JE, Wright DW. Guidelines for the management of severe traumatic brain injury. XIII. Antiseizure prophylaxis. J Neurotrauma. 2007; 24 Suppl 1:S83-6. PMID: 17511552.
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    130. Bratton SL, Chestnut RM, Ghajar J, McConnell Hammond FF, Harris OA, Hartl R, Manley GT, Nemecek A, Newell DW, Rosenthal G, Schouten J, Shutter L, Timmons SD, Ullman JS, Videtta W, Wilberger JE, Wright DW. Guidelines for the management of severe traumatic brain injury. V. Deep vein thrombosis prophylaxis. J Neurotrauma. 2007; 24 Suppl 1:S32-6. PMID: 17511543.
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    131. Bratton SL, Chestnut RM, Ghajar J, McConnell Hammond FF, Harris OA, Hartl R, Manley GT, Nemecek A, Newell DW, Rosenthal G, Schouten J, Shutter L, Timmons SD, Ullman JS, Videtta W, Wilberger JE, Wright DW. Guidelines for the management of severe traumatic brain injury. IV. Infection prophylaxis. J Neurotrauma. 2007; 24 Suppl 1:S26-31. PMID: 17511541.
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    132. Bratton SL, Chestnut RM, Ghajar J, McConnell Hammond FF, Harris OA, Hartl R, Manley GT, Nemecek A, Newell DW, Rosenthal G, Schouten J, Shutter L, Timmons SD, Ullman JS, Videtta W, Wilberger JE, Wright DW. Guidelines for the management of severe traumatic brain injury. VII. Intracranial pressure monitoring technology. J Neurotrauma. 2007; 24 Suppl 1:S45-54. PMID: 17511545.
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    133. Bratton SL, Chestnut RM, Ghajar J, McConnell Hammond FF, Harris OA, Hartl R, Manley GT, Nemecek A, Newell DW, Rosenthal G, Schouten J, Shutter L, Timmons SD, Ullman JS, Videtta W, Wilberger JE, Wright DW. Guidelines for the management of severe traumatic brain injury. VI. Indications for intracranial pressure monitoring. J Neurotrauma. 2007; 24 Suppl 1:S37-44. PMID: 17511544.
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    134. Bratton SL, Chestnut RM, Ghajar J, McConnell Hammond FF, Harris OA, Hartl R, Manley GT, Nemecek A, Newell DW, Rosenthal G, Schouten J, Shutter L, Timmons SD, Ullman JS, Videtta W, Wilberger JE, Wright DW. Guidelines for the management of severe traumatic brain injury. II. Hyperosmolar therapy. J Neurotrauma. 2007; 24 Suppl 1:S14-20. PMID: 17511539.
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    135. Bratton SL, Chestnut RM, Ghajar J, McConnell Hammond FF, Harris OA, Hartl R, Manley GT, Nemecek A, Newell DW, Rosenthal G, Schouten J, Shutter L, Timmons SD, Ullman JS, Videtta W, Wilberger JE, Wright DW. Guidelines for the management of severe traumatic brain injury. X. Brain oxygen monitoring and thresholds. J Neurotrauma. 2007; 24 Suppl 1:S65-70. PMID: 17511548.
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    136. Zador Z, Bloch O, Yao X, Manley GT. Aquaporins: role in cerebral edema and brain water balance. Prog Brain Res. 2007; 161:185-94. PMID: 17618977.
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    137. Bratton SL, Chestnut RM, Ghajar J, McConnell Hammond FF, Harris OA, Hartl R, Manley GT, Nemecek A, Newell DW, Rosenthal G, Schouten J, Shutter L, Timmons SD, Ullman JS, Videtta W, Wilberger JE, Wright DW. Guidelines for the management of severe traumatic brain injury. XV. Steroids. J Neurotrauma. 2007; 24 Suppl 1:S91-5. PMID: 17511554.
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    138. Sorani MD, Hemphill JC, Morabito D, Rosenthal G, Manley GT. New approaches to physiological informatics in neurocritical care. Neurocrit Care. 2007; 7(1):45-52. PMID: 17565451.
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    139. Bratton SL, Chestnut RM, Ghajar J, McConnell Hammond FF, Harris OA, Hartl R, Manley GT, Nemecek A, Newell DW, Rosenthal G, Schouten J, Shutter L, Timmons SD, Ullman JS, Videtta W, Wilberger JE, Wright DW. Guidelines for the management of severe traumatic brain injury. XI. Anesthetics, analgesics, and sedatives. J Neurotrauma. 2007; 24 Suppl 1:S71-6. PMID: 17511550.
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    140. Auguste KI, Jin S, Uchida K, Yan D, Manley GT, Papadopoulos MC, Verkman AS. Greatly impaired migration of implanted aquaporin-4-deficient astroglial cells in mouse brain toward a site of injury. FASEB J. 2007 Jan; 21(1):108-16. PMID: 17135365.
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    141. Chi JH, Knudson MM, Vassar MJ, McCarthy MC, Shapiro MB, Mallet S, Holcroft JJ, Moncrief H, Noble J, Wisner D, Kaups KL, Bennick LD, Manley GT. Prehospital hypoxia affects outcome in patients with traumatic brain injury: a prospective multicenter study. J Trauma. 2006 Nov; 61(5):1134-41. PMID: 17099519.
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    142. Ikossi DG, Knudson MM, Morabito DJ, Cohen MJ, Wan JJ, Khaw L, Stewart CJ, Hemphill C, Manley GT. Continuous muscle tissue oxygenation in critically injured patients: a prospective observational study. J Trauma. 2006 Oct; 61(4):780-8; discussion 788-90. PMID: 17033541.
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    143. Binder DK, Yao X, Zador Z, Sick TJ, Verkman AS, Manley GT. Increased seizure duration and slowed potassium kinetics in mice lacking aquaporin-4 water channels. Glia. 2006 Apr 15; 53(6):631-6. PMID: 16470808.
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    144. Bloch O, Auguste KI, Manley GT, Verkman AS. Accelerated progression of kaolin-induced hydrocephalus in aquaporin-4-deficient mice. J Cereb Blood Flow Metab. 2006 Dec; 26(12):1527-37. PMID: 16552421.
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    145. Manley GT, Rosenthal G, Lam M, Morabito D, Yan D, Derugin N, Bollen A, Knudson MM, Panter SS. Controlled cortical impact in swine: pathophysiology and biomechanics. J Neurotrauma. 2006 Feb; 23(2):128-39. PMID: 16503797.
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    146. Oshio K, Watanabe H, Yan D, Verkman AS, Manley GT. Impaired pain sensation in mice lacking Aquaporin-1 water channels. Biochem Biophys Res Commun. 2006 Mar 24; 341(4):1022-8. PMID: 16476579.
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    147. Binder DK, Yao X, Verkman AS, Manley GT. Increased seizure duration in mice lacking aquaporin-4 water channels. Acta Neurochir Suppl. 2006; 96:389-92. PMID: 16671491.
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    148. Livingston DH, Lavery RF, Mosenthal AC, Knudson MM, Lee S, Morabito D, Manley GT, Nathens A, Jurkovich G, Hoyt DB, Coimbra R. Recovery at one year following isolated traumatic brain injury: a Western Trauma Association prospective multicenter trial. J Trauma. 2005 Dec; 59(6):1298-304; discussion 1304. PMID: 16394900.
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    149. Saadoun S, Papadopoulos MC, Watanabe H, Yan D, Manley GT, Verkman AS. Involvement of aquaporin-4 in astroglial cell migration and glial scar formation. J Cell Sci. 2005 Dec 15; 118(Pt 24):5691-8. PMID: 16303850.
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    150. Padmawar P, Yao X, Bloch O, Manley GT, Verkman AS. K+ waves in brain cortex visualized using a long-wavelength K+-sensing fluorescent indicator. Nat Methods. 2005 Nov; 2(11):825-7. PMID: 16278651.
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    151. Ware ML, Nemani VM, Meeker M, Lee C, Morabito DJ, Manley GT. Effects of 23.4% sodium chloride solution in reducing intracranial pressure in patients with traumatic brain injury: a preliminary study. Neurosurgery. 2005 Oct; 57(4):727-36; discussion 727-36. PMID: 16239885.
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    152. Bloch O, Papadopoulos MC, Manley GT, Verkman AS. Aquaporin-4 gene deletion in mice increases focal edema associated with staphylococcal brain abscess. J Neurochem. 2005 Oct; 95(1):254-62. PMID: 16181429.
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    153. Chi JH, Manley GT, Chou D. Pregnancy-related vertebral hemangioma. Case report, review of the literature, and management algorithm. Neurosurg Focus. 2005 Sep 15; 19(3):E7. PMID: 16190606.
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    154. Quiñones-Hinojosa A, Jun P, Manley GT, Knudson MM, Gupta N. Airbag deployment and improperly restrained children: a lethal combination. J Trauma. 2005 Sep; 59(3):729-33. PMID: 16361920.
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    155. Du R, Meeker M, Bacchetti P, Larson MD, Holland MC, Manley GT. Evaluation of the portable infrared pupillometer. Neurosurgery. 2005 Jul; 57(1):198-203; discussion 198-203. PMID: 15987563.
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    156. Hemphill JC, Smith WS, Sonne DC, Morabito D, Manley GT. Relationship between brain tissue oxygen tension and CT perfusion: feasibility and initial results. AJNR Am J Neuroradiol. 2005 May; 26(5):1095-100. PMID: 15891166.
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    157. Hemphill JC, Barton CW, Morabito D, Manley GT. Influence of data resolution and interpolation method on assessment of secondary brain insults in neurocritical care. Physiol Meas. 2005 Aug; 26(4):373-86. PMID: 15886433.
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    158. Monson KL, Goldsmith W, Barbaro NM, Manley GT. Significance of source and size in the mechanical response of human cerebral blood vessels. J Biomech. 2005 Apr; 38(4):737-44. PMID: 15713294.
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    159. Oshio K, Binder DK, Liang Y, Bollen A, Feuerstein B, Berger MS, Manley GT. Expression of the aquaporin-1 water channel in human glial tumors. Neurosurgery. 2005 Feb; 56(2):375-81; discussion 375-81. PMID: 15670385.
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    160. Meeker M, Du R, Bacchetti P, Privitera CM, Larson MD, Holland MC, Manley G. Pupil examination: validity and clinical utility of an automated pupillometer. J Neurosci Nurs. 2005 Feb; 37(1):34-40. PMID: 15794443.
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    161. Le TH, Mukherjee P, Henry RG, Berman JI, Ware M, Manley GT. Diffusion tensor imaging with three-dimensional fiber tractography of traumatic axonal shearing injury: an imaging correlate for the posterior callosal "disconnection" syndrome: case report. Neurosurgery. 2005; 56(1):189. PMID: 15617604.
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    162. Barton CW, Hemphill JC, Morabito D, Manley G. A novel method of evaluating the impact of secondary brain insults on functional outcomes in traumatic brain-injured patients. Acad Emerg Med. 2005 Jan; 12(1):1-6. PMID: 15635130.
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    163. Hemphill JC, Morabito D, Farrant M, Manley GT. Brain tissue oxygen monitoring in intracerebral hemorrhage. Neurocrit Care. 2005; 3(3):260-70. PMID: 16377842.
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    164. Oshio K, Watanabe H, Song Y, Verkman AS, Manley GT. Reduced cerebrospinal fluid production and intracranial pressure in mice lacking choroid plexus water channel Aquaporin-1. FASEB J. 2005 Jan; 19(1):76-8. PMID: 15533949.
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    165. Papadopoulos MC, Manley GT, Krishna S, Verkman AS. Aquaporin-4 facilitates reabsorption of excess fluid in vasogenic brain edema. FASEB J. 2004 Aug; 18(11):1291-3. PMID: 15208268.
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    166. Mosenthal AC, Livingston DH, Lavery RF, Knudson MM, Lee S, Morabito D, Manley GT, Nathens A, Jurkovich G, Hoyt DB, Coimbra R. The effect of age on functional outcome in mild traumatic brain injury: 6-month report of a prospective multicenter trial. J Trauma. 2004 May; 56(5):1042-8. PMID: 15179244.
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    167. Govindaraju V, Gauger GE, Manley GT, Ebel A, Meeker M, Maudsley AA. Volumetric proton spectroscopic imaging of mild traumatic brain injury. AJNR Am J Neuroradiol. 2004 May; 25(5):730-7. PMID: 15140711.
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    168. Binder DK, Lyon R, Manley GT. Transcranial motor evoked potential recording in a case of Kernohan's notch syndrome: case report. Neurosurgery. 2004 Apr; 54(4):999-1002; discussion 1002-3. PMID: 15046669.
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    169. Binder DK, Oshio K, Ma T, Verkman AS, Manley GT. Increased seizure threshold in mice lacking aquaporin-4 water channels. Neuroreport. 2004 Feb 9; 15(2):259-62. PMID: 15076748.
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    170. Manley GT, Binder DK, Papadopoulos MC, Verkman AS. New insights into water transport and edema in the central nervous system from phenotype analysis of aquaporin-4 null mice. Neuroscience. 2004; 129(4):983-91. PMID: 15561413.
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    171. Papadopoulos MC, Saadoun S, Binder DK, Manley GT, Krishna S, Verkman AS. Molecular mechanisms of brain tumor edema. Neuroscience. 2004; 129(4):1011-20. PMID: 15561416.
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    172. Oshio K, Binder DK, Yang B, Schecter S, Verkman AS, Manley GT. Expression of aquaporin water channels in mouse spinal cord. Neuroscience. 2004; 127(3):685-93. PMID: 15283967.
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    173. Quiñones-Hinojosa A, Binder DK, Hemphill JC, Manley GT. Diagnosis of posttraumatic transverse sinus thrombosis with magnetic resonance imaging/magnetic resonance venography: report of two cases. J Trauma. 2004 Jan; 56(1):201-4. PMID: 14749592.
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    174. Solenov E, Watanabe H, Manley GT, Verkman AS. Sevenfold-reduced osmotic water permeability in primary astrocyte cultures from AQP-4-deficient mice, measured by a fluorescence quenching method. Am J Physiol Cell Physiol. 2004 Feb; 286(2):C426-32. PMID: 14576087.
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    175. Monson KL, Goldsmith W, Barbaro NM, Manley GT. Axial mechanical properties of fresh human cerebral blood vessels. J Biomech Eng. 2003 Apr; 125(2):288-94. PMID: 12751292.
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    176. Knudson MM, Lee S, Erickson V, Morabito D, Derugin N, Manley GT. Tissue oxygen monitoring during hemorrhagic shock and resuscitation: a comparison of lactated Ringer's solution, hypertonic saline dextran, and HBOC-201. J Trauma. 2003 Feb; 54(2):242-52. PMID: 12579047.
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    177. Manley GT, Hemphill JC, Morabito D, Erickson V, Holcroft JJ, Derugin N, Knudson MM. Small-volume resuscitation with the hemoglobin substitute HBOC-201: effect on brain tissue oxygenation. Adv Exp Med Biol. 2003; 530:311-7. PMID: 14562727.
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    178. Oshio K, Binder DK, Bollen A, Verkman AS, Berger MS, Manley GT. Aquaporin-1 expression in human glial tumors suggests a potential novel therapeutic target for tumor-associated edema. Acta Neurochir Suppl. 2003; 86:499-502. PMID: 14753494.
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    179. Oshio K, Song Y, Verkman AS, Manley GT. Aquaporin-1 deletion reduces osmotic water permeability and cerebrospinal fluid production. Acta Neurochir Suppl. 2003; 86:525-8. PMID: 14753499.
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    180. Zhang L, Bae J, Hardy WN, Monson KL, Manley GT, Goldsmith W, Yang KH, King AI. Computational study of the contribution of the vasculature on the dynamic response of the brain. Stapp Car Crash J. 2002 Nov; 46:145-64. PMID: 17096223.
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    181. Lee SK, Morabito D, Hemphill JC, Erickson V, Holcroft JJ, Derugin N, Knudson MM, Manley GT. Small-volume resuscitation with HBOC-201: effects on cardiovascular parameters and brain tissue oxygen tension in an out-of-hospital model of hemorrhage in swine. Acad Emerg Med. 2002 Oct; 9(10):969-76. PMID: 12359531.
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    182. Manley GT, Larson MD. Infrared pupillometry during uncal herniation. J Neurosurg Anesthesiol. 2002 Jul; 14(3):223-8. PMID: 12172296.
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    183. Solenov EI, Vetrivel L, Oshio K, Manley GT, Verkman AS. Optical measurement of swelling and water transport in spinal cord slices from aquaporin null mice. J Neurosci Methods. 2002 Jan 15; 113(1):85-90. PMID: 11741725.
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    184. Manley G, Knudson MM, Morabito D, Damron S, Erickson V, Pitts L. Hypotension, hypoxia, and head injury: frequency, duration, and consequences. Arch Surg. 2001 Oct; 136(10):1118-23. PMID: 11585502.
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    185. Hemphill JC, Bonovich DC, Besmertis L, Manley GT, Johnston SC. The ICH score: a simple, reliable grading scale for intracerebral hemorrhage. Stroke. 2001 Apr; 32(4):891-7. PMID: 11283388.
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    186. Hemphill JC, Knudson MM, Derugin N, Morabito D, Manley GT. Carbon dioxide reactivity and pressure autoregulation of brain tissue oxygen. Neurosurgery. 2001 Feb; 48(2):377-83; discussion 383-4. PMID: 11220382.
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    187. Yang B, Verbavatz JM, Song Y, Vetrivel L, Manley G, Kao WM, Ma T, Verkman AS. Skeletal muscle function and water permeability in aquaporin-4 deficient mice. Am J Physiol Cell Physiol. 2000 Jun; 278(6):C1108-15. PMID: 10837338.
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    188. Manley GT, Hemphill JC, Morabito D, Derugin N, Erickson V, Pitts LH, Knudson MM. Cerebral oxygenation during hemorrhagic shock: perils of hyperventilation and the therapeutic potential of hypoventilation. J Trauma. 2000 Jun; 48(6):1025-32; discussion 1032-3. PMID: 10866246.
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    189. Verkman AS, Yang B, Song Y, Manley GT, Ma T. Role of water channels in fluid transport studied by phenotype analysis of aquaporin knockout mice. Exp Physiol. 2000 Mar; 85 Spec No:233S-241S. PMID: 10795927.
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    190. Manley GT, Dillon W. Acute posterior fossa syndrome following lumbar drainage for treatment of suboccipital pseudomeningocele. Report of three cases. J Neurosurg. 2000 Mar; 92(3):469-74. PMID: 10701537.
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    191. Manley GT, Fujimura M, Ma T, Noshita N, Filiz F, Bollen AW, Chan P, Verkman AS. Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke. Nat Med. 2000 Feb; 6(2):159-63. PMID: 10655103.
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    192. Manley GT, Pitts LH, Morabito D, Doyle CA, Gibson J, Gimbel M, Hopf HW, Knudson MM. Brain tissue oxygenation during hemorrhagic shock, resuscitation, and alterations in ventilation. J Trauma. 1999 Feb; 46(2):261-7. PMID: 10029031.
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    193. George TI, Manley G, Koehler JE, Hung VS, McDermott M, Bollen A. Detection of Bartonella henselae by polymerase chain reaction in brain tissue of an immunocompromised patient with multiple enhancing lesions. Case report and review of the literature. J Neurosurg. 1998 Oct; 89(4):640-4. PMID: 9761060.
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    194. Stockhammer G, Manley GT, Johnson R, Rosenblum MK, Samid D, Lieberman FS. Inhibition of proliferation and induction of differentiation in medulloblastoma- and astrocytoma-derived cell lines with phenylacetate. J Neurosurg. 1995 Oct; 83(4):672-81. PMID: 7674018.
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    195. Manley GA, Köppl C, Konishi M. A neural map of interaural intensity differences in the brain stem of the barn owl. J Neurosci. 1988 Aug; 8(8):2665-76. PMID: 3411346.
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