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    John Kornak, PhD

    TitleAssociate Professor
    SchoolUCSF School of Medicine
    DepartmentEpidemiology & Biostatistics
    Address550 16th Street, 2nd Floor
    San Francisco CA 94158
    Phone415-514-8028

       Biography 
       Education and Training
      University of California, San FranciscoPostdoctoral StudiesGraduate Division
      University of Nottingham, UKPhDStatistics2000
      University of Nottingham, UKB.Sc.Mathematics1996
       Awards and Honors
      Royal Statistical Society1999Elected Fellow
      UCSF CTSI Consultant of the Year Award2009Consistent Excellence Award
      UCSF CTSI Consultant of the Year Award2010Impact Award
      UCSF CTSI Consultant of the Year Award2011Excellence Award

       Overview 
       Overview
      Dr. Kornak received his BSc in Mathematics with Statistics (1996) and Ph.D. in Statistics (2000) from the University of Nottingham, UK. He spent time as a postdoc at UCSF and The Ohio State University before joining the Department of Radiology and Biomedical Imaging at UCSF in 2003. He transferred to Epidemiology and Biostatistics in July 2010.

      He is a biostatistics faculty consultant and the Consultation Services Unit Director in Biostatistics at UCSF's Clinical and Translational Sciences Institute (CTSI). Dr. Kornak's consulting work for the CTSI Consulting Service involves campus-wide statistical consultation and collaboration. The services he provides in that role include help with optimal experimental designs, data analysis, reporting of results, and drafting or editing grant and paper statistical sections. Biostatistical consultation projects that require significant statistical analysis require the coordination of statistical analysts via the development of appropriate analysis plans and the interpretation/dissemination of results.

       Interests
      Bayesian image analysis, Bayesian reconstruction of magnetic resonance imaging, statistical image analysis, Bayesian statistics, spatial statistics

       ORNG Applications 
       Websites

       Bibliographic 
       Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Insel PS, Mattsson N, Mackin RS, Kornak J, Nosheny R, Tosun-Turgut D, Donohue MC, Aisen PS, Weiner MW. Biomarkers and cognitive endpoints to optimize trials in Alzheimer's disease. Ann Clin Transl Neurol. 2015 May; 2(5):534-47.
        View in: PubMed
      2. Sha SJ, Ghosh PM, Lee SE, Corbetta-Rastelli C, Jagust WJ, Kornak J, Rankin KP, Grinberg LT, Vinters HV, Mendez MF, Dickson DW, Seeley WW, Gorno-Tempini M, Kramer J, Miller BL, Boxer AL, Rabinovici GD. Predicting amyloid status in corticobasal syndrome using modified clinical criteria, magnetic resonance imaging and fluorodeoxyglucose positron emission tomography. Alzheimers Res Ther. 2015; 7(1):8.
        View in: PubMed
      3. Sanlorenzo M, Wehner MR, Linos E, Kornak J, Kainz W, Posch C, Vujic I, Johnston K, Gho D, Monico G, McGrath JT, Osella-Abate S, Quaglino P, Cleaver JE, Ortiz-Urda S. The Risk of Melanoma in Airline Pilots and Cabin Crew: A Meta-analysis. JAMA Dermatol. 2015 Jan 1; 151(1):51-8.
        View in: PubMed
      4. Engelke K, Fuerst T, Dardzinski B, Kornak J, Ather S, Genant HK, de Papp A. Odanacatib treatment affects trabecular and cortical bone in the femur of postmenopausal women: results of a two-year placebo-controlled trial. J Bone Miner Res. 2015 Jan; 30(1):30-8.
        View in: PubMed
      5. Tillack AA, Joe BN, Yeh BM, Jun SL, Kornak J, Zhao S, Deng D. Vaginal shape at resting pelvic MRI: predictor of pelvic floor weakness? Clin Imaging. 2015 Mar-Apr; 39(2):285-8.
        View in: PubMed
      6. Shah SC, Kornak J, Khalili M. Depression is not associated with peripheral insulin resistance in patients with chronic hepatitis C infection. J Viral Hepat. 2015 Mar; 22(3):272-80.
        View in: PubMed
      7. Azevedo CJ, Kornak J, Chu P, Sampat M, Okuda DT, Cree BA, Nelson SJ, Hauser SL, Pelletier D. In vivo evidence of glutamate toxicity in multiple sclerosis. Ann Neurol. 2014 Aug; 76(2):269-78.
        View in: PubMed PMC4142752
      8. Llufriu S, Kornak J, Ratiney H, Oh J, Brenneman D, Cree BA, Sampat M, Hauser SL, Nelson SJ, Pelletier D. Magnetic resonance spectroscopy markers of disease progression in multiple sclerosis. JAMA Neurol. 2014 Jul 1; 71(7):840-7.
        View in: PubMed
      9. Johansen KL, Dalrymple LS, Delgado C, Kaysen GA, Kornak J, Grimes B, Chertow GM. Comparison of self-report-based and physical performance-based frailty definitions among patients receiving maintenance hemodialysis. Am J Kidney Dis. 2014 Oct; 64(4):600-7.
        View in: PubMed PMC4177262
      10. Delgado C, Ward P, Chertow GM, Storer L, Dalrymple L, Block T, Kaysen GA, Kornak J, Grimes B, Kutner NG, Johansen KL. Calibration of the brief food frequency questionnaire among patients on dialysis. J Ren Nutr. 2014 May; 24(3):151-156.e1.
        View in: PubMed PMC4145671
      11. Newitt DC, Aliu SO, Witcomb N, Sela G, Kornak J, Esserman L, Hylton NM. Real-Time Measurement of Functional Tumor Volume by MRI to Assess Treatment Response in Breast Cancer Neoadjuvant Clinical Trials: Validation of the Aegis SER Software Platform. Transl Oncol. 2014 Feb; 7(1):94-100.
        View in: PubMed PMC3998689
      12. Aliu SO, Jones EF, Azziz A, Kornak J, Wilmes LJ, Newitt DC, Suzuki SA, Klifa C, Gibbs J, Proctor EC, Joe BN, Hylton NM. Repeatability of quantitative MRI measurements in normal breast tissue. Transl Oncol. 2014 Feb; 7(1):130-7.
        View in: PubMed PMC3998684
      13. Caverzasi E, Henry RG, Vitali P, Lobach IV, Kornak J, Bastianello S, Dearmond SJ, Miller BL, Rosen HJ, Mandelli ML, Geschwind MD. Application of quantitative DTI metrics in sporadic CJD. Neuroimage Clin. 2014; 4:426-35.
        View in: PubMed PMC3950558
      14. Reza J, Sammann A, Jin C, Horvai A, Hudnall M, Jablons DM, Jahan T, Kornak J, Mann MJ. Aggressive and minimally invasive surgery for pulmonary metastasis of sarcoma. J Thorac Cardiovasc Surg. 2014 Apr; 147(4):1193-200; discussion 1200-1.
        View in: PubMed
      15. Jafri NF, Newitt DC, Kornak J, Esserman LJ, Joe BN, Hylton NM. Optimized breast MRI functional tumor volume as a biomarker of recurrence-free survival following neoadjuvant chemotherapy. J Magn Reson Imaging. 2014 Aug; 40(2):476-82.
        View in: PubMed
      16. Wisner DJ, Rogers N, Deshpande VS, Newitt DN, Laub GA, Porter DA, Kornak J, Joe BN, Hylton NM. High-resolution diffusion-weighted imaging for the separation of benign from malignant BI-RADS 4/5 lesions found on breast MRI at 3T. J Magn Reson Imaging. 2014 Sep; 40(3):674-81.
        View in: PubMed PMC4014534
      17. Smith-Bindman R, Lebda P, Feldstein VA, Sellami D, Goldstein RB, Brasic N, Jin C, Kornak J. Risk of thyroid cancer based on thyroid ultrasound imaging characteristics: results of a population-based study. JAMA Intern Med. 2013 Oct 28; 173(19):1788-96.
        View in: PubMed PMC3936789
      18. Johansen KL, Dalrymple LS, Delgado C, Kaysen GA, Kornak J, Grimes B, Chertow GM. Association between body composition and frailty among prevalent hemodialysis patients: a US Renal Data System special study. J Am Soc Nephrol. 2014 Feb; 25(2):381-9.
        View in: PubMed PMC3904567
      19. McLaughlin RL, Newitt DC, Wilmes LJ, Jones EF, Wisner DJ, Kornak J, Proctor E, Joe BN, Hylton NM. High resolution in vivo characterization of apparent diffusion coefficient at the tumor-stromal boundary of breast carcinomas: a pilot study to assess treatment response using proximity-dependent diffusion-weighted imaging. J Magn Reson Imaging. 2014 May; 39(5):1308-13.
        View in: PubMed PMC3983569
      20. Chao SZ, Matthews BR, Yokoyama JS, Lai NB, Ong H, Tse M, Yuan RF, Lin A, Kramer J, Yaffe K, Kornak J, Miller BL, Rosen HJ. Depressive symptoms in chinese-american subjects with cognitive impairment. Am J Geriatr Psychiatry. 2014 Jul; 22(7):642-52.
        View in: PubMed
      21. Kaysen GA, Dalrymple LS, Grimes B, Chertow GM, Kornak J, Johansen KL. Changes in serum inflammatory markers are associated with changes in apolipoprotein A1 but not B after the initiation of dialysis. Nephrol Dial Transplant. 2014 Feb; 29(2):430-7.
        View in: PubMed PMC3910339
      22. Jones EF, Sinha SP, Newitt DC, Klifa C, Kornak J, Park CC, Hylton NM. MRI enhancement in stromal tissue surrounding breast tumors: association with recurrence free survival following neoadjuvant chemotherapy. PLoS One. 2013; 8(5):e61969.
        View in: PubMed PMC3646993
      23. Wilmes LJ, McLaughlin RL, Newitt DC, Singer L, Sinha SP, Proctor E, Wisner DJ, Saritas EU, Kornak J, Shankaranarayanan A, Banerjee S, Jones EF, Joe BN, Hylton NM. High-resolution diffusion-weighted imaging for monitoring breast cancer treatment response. Acad Radiol. 2013 May; 20(5):581-9.
        View in: PubMed
      24. Bakken TE, Roddey JC, Djurovic S, Akshoomoff N, Amaral DG, Bloss CS, Casey BJ, Chang L, Ernst TM, Gruen JR, Jernigan TL, Kaufmann WE, Kenet T, Kennedy DN, Kuperman JM, Murray SS, Sowell ER, Rimol LM, Mattingsdal M, Melle I, Agartz I, Andreassen OA, Schork NJ, Dale AM. Association of common genetic variants in GPCPD1 with scaling of visual cortical surface area in humans. Proc Natl Acad Sci U S A. 2012 Mar 6; 109(10):3985-90.
        View in: PubMed PMC3309762
      25. Lang TF, Sigurdsson S, Karlsdottir G, Oskarsdottir D, Sigmarsdottir A, Chengshi J, Kornak J, Harris TB, Sigurdsson G, Jonsson BY, Siggeirsdottir K, Eiriksdottir G, Gudnason V, Keyak JH. Age-related loss of proximal femoral strength in elderly men and women: the Age Gene/Environment Susceptibility Study--Reykjavik. Bone. 2012 Mar; 50(3):743-8.
        View in: PubMed PMC3278586
      26. Olney NT, Goodkind MS, Lomen-Hoerth C, Whalen PK, Williamson CA, Holley DE, Verstaen A, Brown LM, Miller BL, Kornak J, Levenson RW, Rosen HJ. Behaviour, physiology and experience of pathological laughing and crying in amyotrophic lateral sclerosis. Brain. 2011 Dec; 134(Pt 12):3458-69.
        View in: PubMed PMC3235565
      27. Rabinovici GD, Rosen HJ, Alkalay A, Kornak J, Furst AJ, Agarwal N, Mormino EC, O'Neil JP, Janabi M, Karydas A, Growdon ME, Jang JY, Huang EJ, Dearmond SJ, Trojanowski JQ, Grinberg LT, Gorno-Tempini ML, Seeley WW, Miller BL, Jagust WJ. Amyloid vs FDG-PET in the differential diagnosis of AD and FTLD. Neurology. 2011 Dec 6; 77(23):2034-42.
        View in: PubMed PMC3236517
      28. Weiner MW, Meyerhoff DJ, Neylan TC, Hlavin J, Ramage ER, McCoy D, Studholme C, Cardenas V, Marmar C, Truran D, Chu PW, Kornak J, Furlong CE, McCarthy C. The relationship between Gulf War illness, brain N-acetylaspartate, and post-traumatic stress disorder. Mil Med. 2011 Aug; 176(8):896-902.
        View in: PubMed PMC3279571
      29. Kornak J, Hall DA, Haggard MP. Spatially extended FMRI signal response to stimulus in non-functionally relevant regions of the human brain: preliminary results. Open Neuroimag J. 2011; 5:24-32.
        View in: PubMed PMC3109590
      30. Sutton EJ, Henning TD, Boddington S, Demos S, Krug C, Meier R, Kornak J, Zhao S, Baehner R, Sharifi S, Daldrup-Link H. In vivo magnetic resonance imaging and optical imaging comparison of viable and nonviable mesenchymal stem cells with a bifunctional label. Mol Imaging. 2010 Oct; 9(5):278-90.
        View in: PubMed PMC3060764
      31. Zhao Q, Li W, Li C, Chu PW, Kornak J, Lang TF, Fang J, Lu Y. A statistical method (cross-validation) for bone loss region detection after spaceflight. Australas Phys Eng Sci Med. 2010 Jun; 33(2):163-9.
        View in: PubMed PMC2917547
      32. Blumenkrantz G, Zuo J, Li X, Kornak J, Link TM, Majumdar S. In vivo 3.0-tesla magnetic resonance T1rho and T2 relaxation mapping in subjects with intervertebral disc degeneration and clinical symptoms. Magn Reson Med. 2010 May; 63(5):1193-200.
        View in: PubMed PMC2988488
      33. Beckett LA, Harvey DJ, Gamst A, Donohue M, Kornak J, Zhang H, Kuo JH. The Alzheimer's Disease Neuroimaging Initiative: Annual change in biomarkers and clinical outcomes. Alzheimers Dement. 2010 May; 6(3):257-64.
        View in: PubMed PMC2867839
      34. Ho AJ, Hua X, Lee S, Leow AD, Yanovsky I, Gutman B, Dinov ID, Leporé N, Stein JL, Toga AW, Jack CR, Bernstein MA, Reiman EM, Harvey DJ, Kornak J, Schuff N, Alexander GE, Weiner MW, Thompson PM. Comparing 3 T and 1.5 T MRI for tracking Alzheimer's disease progression with tensor-based morphometry. Hum Brain Mapp. 2010 Apr; 31(4):499-514.
        View in: PubMed PMC2875376
      35. Kornak J, Young K, Soher BJ, Maudsley AA. Bayesian k -space-time reconstruction of MR spectroscopic imaging for enhanced resolution. IEEE Trans Med Imaging. 2010 Jul; 29(7):1333-50.
        View in: PubMed PMC2911978
      36. Hua X, Lee S, Hibar DP, Yanovsky I, Leow AD, Toga AW, Jack CR, Bernstein MA, Reiman EM, Harvey DJ, Kornak J, Schuff N, Alexander GE, Weiner MW, Thompson PM. Mapping Alzheimer's disease progression in 1309 MRI scans: power estimates for different inter-scan intervals. Neuroimage. 2010 May 15; 51(1):63-75.
        View in: PubMed PMC2846999
      37. Chao LL, Buckley ST, Kornak J, Schuff N, Madison C, Yaffe K, Miller BL, Kramer JH, Weiner MW. ASL perfusion MRI predicts cognitive decline and conversion from MCI to dementia. Alzheimer Dis Assoc Disord. 2010 Jan-Mar; 24(1):19-27.
        View in: PubMed PMC2865220
      38. Cohn BR, Joe BN, Zhao S, Kornak J, Zhang VY, Iman R, Kurhanewicz J, Vahidi K, Yu J, Caughey AB, Swanson MG. Quantitative metabolic profiles of 2nd and 3rd trimester human amniotic fluid using (1)H HR-MAS spectroscopy. MAGMA. 2009 Dec; 22(6):343-52.
        View in: PubMed
      39. Hua X, Lee S, Yanovsky I, Leow AD, Chou YY, Ho AJ, Gutman B, Toga AW, Jack CR, Bernstein MA, Reiman EM, Harvey DJ, Kornak J, Schuff N, Alexander GE, Weiner MW, Thompson PM. Optimizing power to track brain degeneration in Alzheimer's disease and mild cognitive impairment with tensor-based morphometry: an ADNI study of 515 subjects. Neuroimage. 2009 Dec; 48(4):668-81.
        View in: PubMed PMC2971697
      40. Cardenas VA, Meyerhoff DJ, Studholme C, Kornak J, Rothlind J, Lampiris H, Neuhaus J, Grant RM, Chao LL, Truran D, Weiner MW. Evidence for ongoing brain injury in human immunodeficiency virus-positive patients treated with antiretroviral therapy. J Neurovirol. 2009 Jul; 15(4):324-33.
        View in: PubMed PMC2889153
      41. Li W, Kornak J, Harris TB, Keyak J, Li C, Lu Y, Cheng X, Lang T. Bone fracture risk estimation based on image similarity. Bone. 2009 Sep; 45(3):560-7.
        View in: PubMed PMC2896043
      42. Leow AD, Yanovsky I, Parikshak N, Hua X, Lee S, Toga AW, Jack CR, Bernstein MA, Britson PJ, Gunter JL, Ward CP, Borowski B, Shaw LM, Trojanowski JQ, Fleisher AS, Harvey D, Kornak J, Schuff N, Alexander GE, Weiner MW, Thompson PM. Alzheimer's disease neuroimaging initiative: a one-year follow up study using tensor-based morphometry correlating degenerative rates, biomarkers and cognition. Neuroimage. 2009 Apr 15; 45(3):645-55.
        View in: PubMed PMC2696624
      43. Kornak J, Young K. K-Bayes reconstruction for perfusion MRI II: modeling and technical development. J Digit Imaging. 2010 Aug; 23(4):374-85.
        View in: PubMed PMC2896642
      44. Westphalen AC, Kurhanewicz J, Cunha RM, Hsu IC, Kornak J, Zhao S, Coakley FV. T2-Weighted endorectal magnetic resonance imaging of prostate cancer after external beam radiation therapy. Int Braz J Urol. 2009 Mar-Apr; 35(2):171-80; discussion 181-2.
        View in: PubMed
      45. Kornak J, Young K, Schuff N, Du A, Maudsley AA, Weiner MW. K-Bayes reconstruction for perfusion MRI. I: concepts and application. J Digit Imaging. 2010 Jun; 23(3):277-86.
        View in: PubMed PMC2865632
      46. Li W, Kornak J, Harris T, Keyak J, Li C, Lu Y, Cheng X, Lang T. Identify fracture-critical regions inside the proximal femur using statistical parametric mapping. Bone. 2009 Apr; 44(4):596-602.
        View in: PubMed PMC2656587
      47. Gazdzinski S, Kornak J, Weiner MW, Meyerhoff DJ. Body mass index and magnetic resonance markers of brain integrity in adults. Ann Neurol. 2008 May; 63(5):652-7.
        View in: PubMed PMC2542059
      48. Ludeman NA, Berman JI, Wu YW, Jeremy RJ, Kornak J, Bartha AI, Barkovich AJ, Ferriero DM, Henry RG, Glenn OA. Diffusion tensor imaging of the pyramidal tracts in infants with motor dysfunction. Neurology. 2008 Nov 18; 71(21):1676-82.
        View in: PubMed
      49. Hua X, Leow AD, Lee S, Klunder AD, Toga AW, Lepore N, Chou YY, Brun C, Chiang MC, Barysheva M, Jack CR, Bernstein MA, Britson PJ, Ward CP, Whitwell JL, Borowski B, Fleisher AS, Fox NC, Boyes RG, Barnes J, Harvey D, Kornak J, Schuff N, Boreta L, Alexander GE, Weiner MW, Thompson PM. 3D characterization of brain atrophy in Alzheimer's disease and mild cognitive impairment using tensor-based morphometry. Neuroimage. 2008 May 15; 41(1):19-34.
        View in: PubMed PMC2556222
      50. Schuff N, Neylan TC, Fox-Bosetti S, Lenoci M, Samuelson KW, Studholme C, Kornak J, Marmar CR, Weiner MW. Abnormal N-acetylaspartate in hippocampus and anterior cingulate in posttraumatic stress disorder. Psychiatry Res. 2008 Feb 28; 162(2):147-57.
        View in: PubMed PMC2443727
      51. Li W, Kezele I, Collins DL, Zijdenbos A, Keyak J, Kornak J, Koyama A, Saeed I, Leblanc A, Harris T, Lu Y, Lang T. Voxel-based modeling and quantification of the proximal femur using inter-subject registration of quantitative CT images. Bone. 2007 Nov; 41(5):888-95.
        View in: PubMed PMC2080679
      52. Zhu X, Schuff N, Kornak J, Soher B, Yaffe K, Kramer JH, Ezekiel F, Miller BL, Jagust WJ, Weiner MW. Effects of Alzheimer disease on fronto-parietal brain N-acetyl aspartate and myo-inositol using magnetic resonance spectroscopic imaging. Alzheimer Dis Assoc Disord. 2006 Apr-Jun; 20(2):77-85.
        View in: PubMed PMC1820860
      53. Leow AD, Klunder AD, Jack CR, Toga AW, Dale AM, Bernstein MA, Britson PJ, Gunter JL, Ward CP, Whitwell JL, Borowski BJ, Fleisher AS, Fox NC, Harvey D, Kornak J, Schuff N, Studholme C, Alexander GE, Weiner MW, Thompson PM. Longitudinal stability of MRI for mapping brain change using tensor-based morphometry. Neuroimage. 2006 Jun; 31(2):627-40.
        View in: PubMed PMC1941663
      54. Hayasaka S, Du AT, Duarte A, Kornak J, Jahng GH, Weiner MW, Schuff N. A non-parametric approach for co-analysis of multi-modal brain imaging data: application to Alzheimer's disease. Neuroimage. 2006 Apr 15; 30(3):768-79.
        View in: PubMed PMC1838962
      55. Du AT, Schuff N, Chao LL, Kornak J, Jagust WJ, Kramer JH, Reed BR, Miller BL, Norman D, Chui HC, Weiner MW. Age effects on atrophy rates of entorhinal cortex and hippocampus. Neurobiol Aging. 2006 May; 27(5):733-40.
        View in: PubMed PMC1779763
      56. Du AT, Schuff N, Chao LL, Kornak J, Ezekiel F, Jagust WJ, Kramer JH, Reed BR, Miller BL, Norman D, Chui HC, Weiner MW. White matter lesions are associated with cortical atrophy more than entorhinal and hippocampal atrophy. Neurobiol Aging. 2005 Apr; 26(4):553-9.
        View in: PubMed
      57. Young K, Chen Y, Kornak J, Matson GB, Schuff N. Summarizing complexity in high dimensions. Phys Rev Lett. 2005 Mar 11; 94(9):098701.
        View in: PubMed
      58. Ezekiel F, Chao L, Kornak J, Du AT, Cardenas V, Truran D, Jagust W, Chui H, Miller B, Yaffe K, Schuff N, Weiner M. Comparisons between global and focal brain atrophy rates in normal aging and Alzheimer disease: Boundary Shift Integral versus tracing of the entorhinal cortex and hippocampus. Alzheimer Dis Assoc Disord. 2004 Oct-Dec; 18(4):196-201.
        View in: PubMed PMC1820853
      59. Hall DA, Gonçalves MS, Smith S, Jezzard P, Haggard MP, Kornak J. A method for determining venous contribution to BOLD contrast sensory activation. Magn Reson Imaging. 2002 Dec; 20(10):695-706.
        View in: PubMed
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