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Ma Somsouk, MD, MAS

TitleAssociate Professor
SchoolUCSF School of Medicine
DepartmentMedicine
Address1001 Potrero Ave, SFGH 5
San Francisco CA 94110
Phone415-206-6480
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    Collapse Biography 
    Collapse Education and Training
    UCSF, Epidemiology and BiostatisticsM.A.S. 2008
    UCSF, Gastroenterology & HepatologyFellowship2008
    Harvard Medical SchoolM.D.2002
    UCLA-Harbor Medical CenterResidency2005
    Beijing Medical University, Research ScholarFellowship2001
    Pomona College, ChemistryB.A.1997
    Collapse Awards and Honors
    UCSF2016Dean M. Craig Endowed Chair in Gastrointestinal Medicine
    American Gastroenterology Association2015AGA Fellow
    UCSF Academic Senate Nomination2015Distinction in Mentoring
    Harvard2001Paul Dudley White / Andrew Sellard Fellowship
    Pomona College1997Magna Cum Laude

    Collapse Overview 
    Collapse Overview
    1. Precision population health. Quality of care for patient populations can be enhanced by embracing health information technology paired with tailored interventions. Dr. Somsouk's research program is funded by CDC, in partnership with the SF Department of Public Health, to examine how patient panel management can be employed to improve the continuum of colorectal cancer screening as a model condition. Randomized designs test health interventions and health economic approaches quantify the value of efficacious activities.

    2. Intestinal mucosal biology. The gastrointestinal tract is a major site of disease pathogenesis. One major focus is HIV, quantifying the HIV reservoir and host control. Another focus is targeted interventions to modulate the microbiota. Approaches employed: organoid models, isolation of epithelial cells, lymphocytes, microbiota, and interventional trials such as fecal transplant.


    Collapse Research 
    Collapse Research Activities and Funding
    Delaney AIDS Research Enterprise to Cure HIV
    NIH/NIAID UM1AI126611Jul 14, 2016 - Jun 30, 2021
    Role: Co-Investigator
    Institute for HIV CURE Research
    amfAR 109301-59-RGRLJan 1, 2016 - Dec 31, 2020
    Role: Co-Investigator
    Intestinal MAIT Cells in HIV Infection
    NIH R01DK108350Sep 22, 2015 - Aug 31, 2020
    Role: Co-Investigator
    Investigating Mechanisms of HIV Persistence in the Gut
    NIH/NIDDK R01DK108349Sep 21, 2015 - Aug 31, 2020
    Role: Co-Investigator
    Fecal microbial transplantation to reduce HIV-associated inflammation
    NIH/NIDDK R21DK104664Aug 1, 2015 - Jul 31, 2017
    Role: Principal Investigator
    Timing of ART and homeostasis of the persistent HIV reservoir in the adult
    NIH/NIAID R01AI116368Feb 4, 2015 - Jan 31, 2020
    Role: Co-Investigator
    Mailed FIT to Improve Colorectal Cancer Screening in the San Francisco Safety-Net System by Centralized Population Management
    CDC U48DP004998Sep 1, 2014 - Aug 30, 2019
    Role: Principal Investigator
    Understanding barriers to colorectal cancer screening in South Asians
    CDC U48DP004998-01S4Sep 1, 2014 - Mar 31, 2016
    Role: Principal Investigator
    Determinants of Functional Immune Defects in Treated HIV Infection and Aging
    NIH/NIAID R01AI110271Jun 1, 2014 - May 31, 2019
    Role: Co-Investigator
    Gut barrier dysfunction and dysbiosis on HIV persistence and immune activation
    NIH P30AI027763Sep 1, 2013 - Aug 31, 2016
    Role: Principal Investigator
    HIV, Gut Mucosal Turnover and Inflammation, and the Risk of Colorectal Neoplasia
    NIH/NCI K23CA157929Sep 22, 2011 - Aug 31, 2016
    Role: Principal Investigator
    HIV-Specific T Cell Responses in Rectal Mucosa
    NIH R01AI057020Jul 11, 2003 - May 31, 2017
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse In The News
    Collapse Clinical Trials
    Collapse Global Health

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Kiniry BE, Ganesh A, Critchfield JW, Hunt PW, Hecht FM, Somsouk M, Deeks SG, Shacklett BL. Predominance of weakly cytotoxic, T-bet(Low)Eomes(Neg) CD8(+) T-cells in human gastrointestinal mucosa: implications for HIV infection. Mucosal Immunol. 2016 Nov 09. PMID: 27827375.
      View in: PubMed
    2. Paquin-Proulx D, Ching C, Vujkovic-Cvijin I, Fadrosh D, Loh L, Huang Y, Somsouk M, Lynch SV, Hunt PW, Nixon DF, SenGupta D. Bacteroides are associated with GALT iNKT cell function and reduction of microbial translocation in HIV-1 infection. Mucosal Immunol. 2016 Apr 6. PMID: 27049061.
      View in: PubMed
    3. Shergill AK, Conners EE, McQuaid KR, Epstein S, Ryan JC, Shah JN, Inadomi J, Somsouk M. Protective association of colonoscopy against proximal and distal colon cancer and patterns in interval cancer. Gastrointest Endosc. 2015 Sep; 82(3):529-37.e1. PMID: 25936449; PMCID: PMC4540647 [Available on 09/01/16].
    4. von Stockenstrom S, Odevall L, Lee E, Sinclair E, Bacchetti P, Killian M, Epling L, Shao W, Hoh R, Ho T, Faria NR, Lemey P, Albert J, Hunt P, Loeb L, Pilcher C, Poole L, Hatano H, Somsouk M, Douek D, Boritz E, Deeks SG, Hecht FM, Palmer S. Longitudinal Genetic Characterization Reveals That Cell Proliferation Maintains a Persistent HIV Type 1 DNA Pool During Effective HIV Therapy. J Infect Dis. 2015 Aug 15; 212(4):596-607. PMID: 25712966; PMCID: PMC4539896 [Available on 08/15/16].
    5. Somsouk M, Estes JD, Deleage C, Dunham RM, Albright R, Inadomi JM, Martin JN, Deeks SG, McCune JM, Hunt PW. Gut epithelial barrier and systemic inflammation during chronic HIV infection. AIDS. 2015 Jan 2; 29(1):43-51. PMID: 25387317; PMCID: PMC4444362 [Available on 01/02/16].
    6. Somsouk M, Dunham RM, Cohen M, Albright R, Abdel-Mohsen M, Liegler T, Lifson J, Piatak M, Gorelick R, Huang Y, Wu Y, Hsue PY, Martin JN, Deeks SG, McCune JM, Hunt PW. The immunologic effects of mesalamine in treated HIV-infected individuals with incomplete CD4+ T cell recovery: a randomized crossover trial. PLoS One. 2014; 9(12):e116306. PMID: 25545673; PMCID: PMC4283685.
    7. Sanchez JL, Hunt PW, Reilly CS, Hatano H, Beilman GJ, Khoruts A, Jasurda JS, Somsouk M, Thorkelson A, Russ S, Anderson J, Deeks SG, Schacker TW. Lymphoid fibrosis occurs in long-term nonprogressors and persists with antiretroviral therapy but may be reversible with curative interventions. J Infect Dis. 2015 Apr 1; 211(7):1068-75. PMID: 25344521; PMCID: PMC4416122 [Available on 04/01/16].
    8. Ribeiro SP, Milush JM, Cunha-Neto E, Kallas EG, Kalil J, Somsouk M, Hunt PW, Deeks SG, Nixon DF, SenGupta D. The CD8? memory stem T cell (T(SCM)) subset is associated with improved prognosis in chronic HIV-1 infection. J Virol. 2014 Dec; 88(23):13836-44. PMID: 25253339; PMCID: PMC4248986.
    9. Serrano-Villar S, Sainz T, Lee SA, Hunt PW, Sinclair E, Shacklett BL, Ferre AL, Hayes TL, Somsouk M, Hsue PY, Van Natta ML, Meinert CL, Lederman MM, Hatano H, Jain V, Huang Y, Hecht FM, Martin JN, McCune JM, Moreno S, Deeks SG. HIV-infected individuals with low CD4/CD8 ratio despite effective antiretroviral therapy exhibit altered T cell subsets, heightened CD8+ T cell activation, and increased risk of non-AIDS morbidity and mortality. PLoS Pathog. 2014 May; 10(5):e1004078. PMID: 24831517; PMCID: PMC4022662.
    10. Somsouk M, To'o K, Ali M, Vittinghoff E, Yeh BM, Yee J, Monto A, Inadomi JM, Aslam R. Esophageal varices on computed tomography and subsequent variceal hemorrhage. Abdom Imaging. 2014 Apr; 39(2):251-6. PMID: 24366107; PMCID: PMC3979277.
    11. Gupta S, Sussman DA, Doubeni CA, Anderson DS, Day L, Deshpande AR, Elmunzer BJ, Laiyemo AO, Mendez J, Somsouk M, Allison J, Bhuket T, Geng Z, Green BB, Itzkowitz SH, Martinez ME. Challenges and possible solutions to colorectal cancer screening for the underserved. J Natl Cancer Inst. 2014 Apr; 106(4):dju032. PMID: 24681602; PMCID: PMC3982886.
    12. Day LW, Siao D, Inadomi JM, Somsouk M. Non-physician performance of lower and upper endoscopy: a systematic review and meta-analysis. Endoscopy. 2014 May; 46(5):401-10. PMID: 24627086; PMCID: PMC4153714.
    13. Day LW, Lin L, Somsouk M. Adverse events in older patients undergoing ERCP: a systematic review and meta-analysis. Endosc Int Open. 2014 Mar; 2(1):E28-36. PMID: 26134610; PMCID: PMC4423280.
    14. Dunham RM, Vujkovic-Cvijin I, Yukl SA, Broadhurst MJ, Loke P, Albright RG, Wong JK, Lederman MM, Somsouk M, Hunt PW, Martin JN, Deeks SG, McCune JM. Discordance between peripheral and colonic markers of inflammation during suppressive ART. J Acquir Immune Defic Syndr. 2014 Feb 1; 65(2):133-41. PMID: 24121758; PMCID: PMC3997573.
    15. Yukl SA, Sinclair E, Somsouk M, Hunt PW, Epling L, Killian M, Girling V, Li P, Havlir DV, Deeks SG, Wong JK, Hatano H. A comparison of methods for measuring rectal HIV levels suggests that HIV DNA resides in cells other than CD4+ T cells, including myeloid cells. AIDS. 2014 Jan 28; 28(3):439-42. PMID: 24322272; PMCID: PMC4130176.
    16. Sewell JL, Somsouk M, Shah SC, Day LW. Commentary: Towards an effective and safe treatment of small intestine bacterial overgrowth - Authors' reply. Aliment Pharmacol Ther. 2013 Dec; 38(11-12):1411. PMID: 24206377.
      View in: PubMed
    17. Josefsson L, von Stockenstrom S, Faria NR, Sinclair E, Bacchetti P, Killian M, Epling L, Tan A, Ho T, Lemey P, Shao W, Hunt PW, Somsouk M, Wylie W, Douek DC, Loeb L, Custer J, Hoh R, Poole L, Deeks SG, Hecht F, Palmer S. The HIV-1 reservoir in eight patients on long-term suppressive antiretroviral therapy is stable with few genetic changes over time. Proc Natl Acad Sci U S A. 2013 Dec 17; 110(51):E4987-96. PMID: 24277811; PMCID: PMC3870728.
    18. Hatano H, Yukl SA, Ferre AL, Graf EH, Somsouk M, Sinclair E, Abdel-Mohsen M, Liegler T, Harvill K, Hoh R, Palmer S, Bacchetti P, Hunt PW, Martin JN, McCune JM, Tracy RP, Busch MP, O'Doherty U, Shacklett BL, Wong JK, Deeks SG. Prospective antiretroviral treatment of asymptomatic, HIV-1 infected controllers. PLoS Pathog. 2013; 9(10):e1003691. PMID: 24130489; PMCID: PMC3795031.
    19. Siao D, Somsouk M. Helicobacter pylori: evidence-based review with a focus on immigrant populations. J Gen Intern Med. 2014 Mar; 29(3):520-8. PMID: 24065381; PMCID: PMC3930769.
    20. Hatano H, Somsouk M, Sinclair E, Harvill K, Gilman L, Cohen M, Hoh R, Hunt PW, Martin JN, Wong JK, Deeks SG, Yukl SA. Comparison of HIV DNA and RNA in gut-associated lymphoid tissue of HIV-infected controllers and noncontrollers. AIDS. 2013 Sep 10; 27(14):2255-60. PMID: 24157906; PMCID: PMC4143147.
    21. Shah SC, Day LW, Somsouk M, Sewell JL. Meta-analysis: antibiotic therapy for small intestinal bacterial overgrowth. Aliment Pharmacol Ther. 2013 Oct; 38(8):925-34. PMID: 24004101; PMCID: PMC3819138.
    22. Vujkovic-Cvijin I, Dunham RM, Iwai S, Maher MC, Albright RG, Broadhurst MJ, Hernandez RD, Lederman MM, Huang Y, Somsouk M, Deeks SG, Hunt PW, Lynch SV, McCune JM. Dysbiosis of the gut microbiota is associated with HIV disease progression and tryptophan catabolism. Sci Transl Med. 2013 Jul 10; 5(193):193ra91. PMID: 23843452; PMCID: PMC4094294.
    23. Hunt PW, Shulman NS, Hayes TL, Dahl V, Somsouk M, Funderburg NT, McLaughlin B, Landay AL, Adeyemi O, Gilman LE, Clagett B, Rodriguez B, Martin JN, Schacker TW, Shacklett BL, Palmer S, Lederman MM, Deeks SG. The immunologic effects of maraviroc intensification in treated HIV-infected individuals with incomplete CD4+ T-cell recovery: a randomized trial. Blood. 2013 Jun 6; 121(23):4635-46. PMID: 23589670; PMCID: PMC3685899.
    24. Ho C, Kornfield R, Vittinghoff E, Inadomi J, Yee H, Somsouk M. Late presentation of colorectal cancer in a vulnerable population. Am J Gastroenterol. 2013 Apr; 108(4):466-70. PMID: 23552303; PMCID: PMC3740533.
    25. Eriksson S, Graf EH, Dahl V, Strain MC, Yukl SA, Lysenko ES, Bosch RJ, Lai J, Chioma S, Emad F, Abdel-Mohsen M, Hoh R, Hecht F, Hunt P, Somsouk M, Wong J, Johnston R, Siliciano RF, Richman DD, O'Doherty U, Palmer S, Deeks SG, Siliciano JD. Comparative analysis of measures of viral reservoirs in HIV-1 eradication studies. PLoS Pathog. 2013 Feb; 9(2):e1003174. PMID: 23459007; PMCID: PMC3573107.
    26. Leeansyah E, Ganesh A, Quigley MF, Sönnerborg A, Andersson J, Hunt PW, Somsouk M, Deeks SG, Martin JN, Moll M, Shacklett BL, Sandberg JK. Activation, exhaustion, and persistent decline of the antimicrobial MR1-restricted MAIT-cell population in chronic HIV-1 infection. Blood. 2013 Feb 14; 121(7):1124-35. PMID: 23243281; PMCID: PMC3575756.
    27. Shaw JM, Hunt PW, Critchfield JW, McConnell DH, Garcia JC, Pollard RB, Somsouk M, Deeks SG, Shacklett BL. Short communication: HIV+ viremic slow progressors maintain low regulatory T cell numbers in rectal mucosa but exhibit high T cell activation. AIDS Res Hum Retroviruses. 2013 Jan; 29(1):172-7. PMID: 22998457; PMCID: PMC3537318.
    28. Inadomi JM, Vijan S, Janz NK, Fagerlin A, Thomas JP, Lin YV, Muñoz R, Lau C, Somsouk M, El-Nachef N, Hayward RA. Adherence to colorectal cancer screening: a randomized clinical trial of competing strategies. Arch Intern Med. 2012 Apr 9; 172(7):575-82. PMID: 22493463; PMCID: PMC3360917.
    29. Day LW, Kwon A, Inadomi JM, Walter LC, Somsouk M. Adverse events in older patients undergoing colonoscopy: a systematic review and meta-analysis. Gastrointest Endosc. 2011 Oct; 74(4):885-96. PMID: 21951478; PMCID: PMC3371336.
    30. Day LW, Cello JP, Somsouk M, Inadomi JM. Prevalence of gastric cancer versus colorectal cancer in Asians with a positive fecal occult blood test. Indian J Gastroenterol. 2011 Sep; 30(5):209-16. PMID: 21948130.
      View in: PubMed
    31. Shaw JM, Hunt PW, Critchfield JW, McConnell DH, Garcia JC, Pollard RB, Somsouk M, Deeks SG, Shacklett BL. Increased frequency of regulatory T cells accompanies increased immune activation in rectal mucosae of HIV-positive noncontrollers. J Virol. 2011 Nov; 85(21):11422-34. PMID: 21880771; PMCID: PMC3194952.
    32. Somsouk M, Kornfield R, Vittinghoff E, Inadomi JM, Biggins SW. Moderate ascites identifies patients with low model for end-stage liver disease scores awaiting liver transplantation who have a high mortality risk. Liver Transpl. 2011 Feb; 17(2):129-36. PMID: 21280185; PMCID: PMC3058247.
    33. Somsouk M, Guy J, Biggins SW, Vittinghoff E, Kohn MA, Inadomi JM. Ascites improves upon [corrected] serum sodium plus [corrected] model for end-stage liver disease (MELD) for predicting mortality in patients with advanced liver disease. Aliment Pharmacol Ther. 2009 Oct; 30(7):741-8. PMID: 19604177; PMCID: PMC2742706.
    34. Guy J, Somsouk M, Shiboski S, Kerlan R, Inadomi JM, Biggins SW. New model for end stage liver disease improves prognostic capability after transjugular intrahepatic portosystemic shunt. Clin Gastroenterol Hepatol. 2009 Nov; 7(11):1236-40. PMID: 19560557; PMCID: PMC2783337.
    35. Somsouk M, Yee HF, Biggins SW. Understanding liver health using the National Center for Health Statistics. Dig Dis Sci. 2009 Nov; 54(11):2325-9. PMID: 19424799; PMCID: PMC2762048.
    36. Inadomi JM, Somsouk M, Madanick RD, Thomas JP, Shaheen NJ. A cost-utility analysis of ablative therapy for Barrett's esophagus. Gastroenterology. 2009 Jun; 136(7):2101-2114.e1-6. PMID: 19272389; PMCID: PMC2693449.
    37. Somsouk M, Gralnek IM, Inadomi JM. Management of obscure occult gastrointestinal bleeding: a cost-minimization analysis. Clin Gastroenterol Hepatol. 2008 Jun; 6(6):661-70. PMID: 18550005; PMCID: PMC2652579.
    38. Somsouk M, Shergill AK, Grenert JP, Harris H, Cello JP, Shah JN. Actinomycosis mimicking a pancreatic head neoplasm diagnosed by EUS-guided FNA. Gastrointest Endosc. 2008 Jul; 68(1):186-7. PMID: 18291393.
      View in: PubMed
    39. Somsouk M, Langfield DE, Inadomi JM, Yee HF. A cost-identification analysis of screening and surveillance of hepatitis C infection in a prospective cohort of dialysis patients. Dig Dis Sci. 2008 Apr; 53(4):1093-9. PMID: 17934829.
      View in: PubMed
    40. Inadomi JM, Somsouk MA. Will virtual colonoscopy replace optical colonoscopy for colorectal cancer screening? Gastroenterology. 2007 Oct; 133(4):1384-5; discussion 1385-6. PMID: 17919513.
      View in: PubMed
    41. Inadomi JM, Somsouk MA. Proton pump inhibitors and hip fracture: cause for alarm? Gastroenterology. 2007 May; 132(5):2063-5; discussion 2065. PMID: 17484900.
      View in: PubMed
    42. Steinmetz WE, Sparrow A, Somsouk M. Determination of the three-dimensional, solution-phase structure of the macrolide antibiotic oxolide in CD2Cl2 and D2O from NMR constraints. Magn Reson Chem. 2005 Jan; 43(1):16-20. PMID: 15468276.
      View in: PubMed
    43. Ma XT, Wang S, Ye YJ, Du RY, Cui ZR, Somsouk M. Constitutive activation of Stat3 signaling pathway in human colorectal carcinoma. World J Gastroenterol. 2004 Jun 1; 10(11):1569-73. PMID: 15162527; PMCID: PMC4572756.
    44. Delgado-Borrego A, Casson D, Schoenfeld D, Somsouk M, Terella A, Jordan SH, Bhan A, Baid S, Cosimi AB, Pascual M, Chung RT. Hepatitis C virus is independently associated with increased insulin resistance after liver transplantation. Transplantation. 2004 Mar 15; 77(5):703-10. PMID: 15021833.
      View in: PubMed
    45. Heckman CA, Cao T, Somsouk L, Duan H, Mehew JW, Zhang CY, Boxer LM. Critical elements of the immunoglobulin heavy chain gene enhancers for deregulated expression of bcl-2. Cancer Res. 2003 Oct 15; 63(20):6666-73. PMID: 14583460.
      View in: PubMed
    46. Somsouk M, Lauer GM, Casson D, Terella A, Day CL, Walker BD, Chung RT. Spontaneous resolution of chronic hepatitis C virus disease after withdrawal of immunosuppression. Gastroenterology. 2003 Jun; 124(7):1946-9. PMID: 12806627.
      View in: PubMed
    47. Bouziane M, Miao F, Bates SE, Somsouk L, Sang BC, Denissenko M, O'Connor TR. Promoter structure and cell cycle dependent expression of the human methylpurine-DNA glycosylase gene. Mutat Res. 2000 Sep 15; 461(1):15-29. PMID: 10980409.
      View in: PubMed
    48. Frank G, Qiu J, Somsouk M, Weng Y, Somsouk L, Nolan JP, Shen B. Partial functional deficiency of E160D flap endonuclease-1 mutant in vitro and in vivo is due to defective cleavage of DNA substrates. J Biol Chem. 1998 Dec 4; 273(49):33064-72. PMID: 9830061.
      View in: PubMed
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