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    Ma Somsouk

    TitleAssistant Professor
    SchoolUCSF School of Medicine
    DepartmentMedicine
    Address1001 Potrero Ave, SFGH 5
    San Francisco CA 94143
    Phone415-206-6480

       Overview 
       Overview
      1. Gastrointestinal tract as a reservoir and site of HIV pathogenesis. We study the impact of HIV in the gut, answering questions related to viral persistence, immune activation, epithelial barrier dysfunction, and their relationship to systemic inflammation, aging, and cancer using observational studies and interventional trials.
      2. Prevention of colorectal cancer. The SFGH population often presents with late-stage cancer, particularly among Asians and blacks, with low rates of colorectal cancer screening and late utilization of health care services. We identify barriers to access healthcare / colorectal cancer screening in the safety-net population. In addition to cohort studies, we use mathematical simulation models to identify challenges and best practices for colorectal cancer screening / surveillance.

      2006-2008 Master's in Epidemiology and Biostatistics, UCSF
      2005-2008 Gastroenterology Fellowship, UCSF
      2002-2005 Residency in Internal Medicine, UCLA-Harbor
      2000-2001 Paul Dudley White / Andrew Sellard Fellowship, Beijing University
      1997-2002 Harvard Medical School
      1993-1997 Pomona College, Chemistry, Magna Cum Laude


       Bibliographic 
       Publications
      Publications by year:
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      1. Ho C, Kornfield R, Vittinghoff E, Inadomi J, Yee H, Somsouk M. Late presentation of colorectal cancer in a vulnerable population. Am J Gastroenterol. 2013 Apr; 108(4):466-70.
        View in: PubMed
      2. Eriksson S, Graf EH, Dahl V, Strain MC, Yukl SA, Lysenko ES, Bosch RJ, Lai J, Chioma S, Emad F, Abdel-Mohsen M, Hoh R, Hecht F, Hunt P, Somsouk M, Wong J, Johnston R, Siliciano RF, Richman DD, O'Doherty U, Palmer S, Deeks SG, Siliciano JD. Comparative Analysis of Measures of Viral Reservoirs in HIV-1 Eradication Studies. PLoS Pathog. 2013 Feb; 9(2):e1003174.
        View in: PubMed
      3. Leeansyah E, Ganesh A, Quigley MF, Sönnerborg A, Andersson J, Hunt PW, Somsouk M, Deeks SG, Martin JN, Moll M, Shacklett BL, Sandberg JK. Activation, exhaustion, and persistent decline of the antimicrobial MR1-restricted MAIT-cell population in chronic HIV-1 infection. Blood. 2013 Feb 14; 121(7):1124-35.
        View in: PubMed
      4. Shaw JM, Hunt PW, Critchfield JW, McConnell DH, Garcia JC, Pollard RB, Somsouk M, Deeks SG, Shacklett BL. Short Communication: HIV(+) Viremic Slow Progressors Maintain Low Regulatory T Cell Numbers in Rectal Mucosa but Exhibit High T Cell Activation. AIDS Res Hum Retroviruses. 2013 Jan; 29(1):172-7.
        View in: PubMed
      5. Day LW, Kwon A, Inadomi JM, Walter LC, Somsouk M. Adverse events in older patients undergoing colonoscopy: a systematic review and meta-analysis. Gastrointest Endosc. 2011 Oct; 74(4):885-96.
        View in: PubMed
      6. Day LW, Cello JP, Somsouk M, Inadomi JM. Prevalence of gastric cancer versus colorectal cancer in Asians with a positive fecal occult blood test. Indian J Gastroenterol. 2011 Sep; 30(5):209-16.
        View in: PubMed
      7. Shaw JM, Hunt PW, Critchfield JW, McConnell DH, Garcia JC, Pollard RB, Somsouk M, Deeks SG, Shacklett BL. Increased frequency of regulatory T cells accompanies increased immune activation in rectal mucosae of HIV-positive noncontrollers. J Virol. 2011 Nov; 85(21):11422-34.
        View in: PubMed
      8. Somsouk M, Kornfield R, Vittinghoff E, Inadomi JM, Biggins SW. Moderate ascites identifies patients with low model for end-stage liver disease scores awaiting liver transplantation who have a high mortality risk. Liver Transpl. 2011 Feb; 17(2):129-36.
        View in: PubMed
      9. Somsouk M, Guy J, Biggins SW, Vittinghoff E, Kohn MA, Inadomi JM. Ascites improves upon [corrected] serum sodium plus [corrected] model for end-stage liver disease (MELD) for predicting mortality in patients with advanced liver disease. Aliment Pharmacol Ther. 2009 Oct; 30(7):741-8.
        View in: PubMed
      10. Guy J, Somsouk M, Shiboski S, Kerlan R, Inadomi JM, Biggins SW. New model for end stage liver disease improves prognostic capability after transjugular intrahepatic portosystemic shunt. Clin Gastroenterol Hepatol. 2009 Nov; 7(11):1236-40.
        View in: PubMed
      11. Somsouk M, Yee HF, Biggins SW. Understanding liver health using the National Center for Health Statistics. Dig Dis Sci. 2009 Nov; 54(11):2325-9.
        View in: PubMed
      12. Inadomi JM, Somsouk M, Madanick RD, Thomas JP, Shaheen NJ. A cost-utility analysis of ablative therapy for Barrett's esophagus. Gastroenterology. 2009 Jun; 136(7):2101-2114.e1-6.
        View in: PubMed
      13. Somsouk M, Gralnek IM, Inadomi JM. Management of obscure occult gastrointestinal bleeding: a cost-minimization analysis. Clin Gastroenterol Hepatol. 2008 Jun; 6(6):661-70.
        View in: PubMed
      14. Somsouk M, Shergill AK, Grenert JP, Harris H, Cello JP, Shah JN. Actinomycosis mimicking a pancreatic head neoplasm diagnosed by EUS-guided FNA. Gastrointest Endosc. 2008 Jul; 68(1):186-7.
        View in: PubMed
      15. Somsouk M, Langfield DE, Inadomi JM, Yee HF. A cost-identification analysis of screening and surveillance of hepatitis C infection in a prospective cohort of dialysis patients. Dig Dis Sci. 2008 Apr; 53(4):1093-9.
        View in: PubMed
      16. Inadomi JM, Somsouk MA. Will virtual colonoscopy replace optical colonoscopy for colorectal cancer screening? Gastroenterology. 2007 Oct; 133(4):1384-5; discussion 1385-6.
        View in: PubMed
      17. Inadomi JM, Somsouk MA. Proton pump inhibitors and hip fracture: cause for alarm? Gastroenterology. 2007 May; 132(5):2063-5; discussion 2065.
        View in: PubMed
      18. Steinmetz WE, Sparrow A, Somsouk M. Determination of the three-dimensional, solution-phase structure of the macrolide antibiotic oxolide in CD2Cl2 and D2O from NMR constraints. Magn Reson Chem. 2005 Jan; 43(1):16-20.
        View in: PubMed
      19. Ma XT, Wang S, Ye YJ, Du RY, Cui ZR, Somsouk M. Constitutive activation of Stat3 signaling pathway in human colorectal carcinoma. World J Gastroenterol. 2004 Jun 1; 10(11):1569-73.
        View in: PubMed
      20. Delgado-Borrego A, Casson D, Schoenfeld D, Somsouk M, Terella A, Jordan SH, Bhan A, Baid S, Cosimi AB, Pascual M, Chung RT. Hepatitis C virus is independently associated with increased insulin resistance after liver transplantation. Transplantation. 2004 Mar 15; 77(5):703-10.
        View in: PubMed
      21. Heckman CA, Cao T, Somsouk L, Duan H, Mehew JW, Zhang CY, Boxer LM. Critical elements of the immunoglobulin heavy chain gene enhancers for deregulated expression of bcl-2. Cancer Res. 2003 Oct 15; 63(20):6666-73.
        View in: PubMed
      22. Somsouk M, Lauer GM, Casson D, Terella A, Day CL, Walker BD, Chung RT. Spontaneous resolution of chronic hepatitis C virus disease after withdrawal of immunosuppression. Gastroenterology. 2003 Jun; 124(7):1946-9.
        View in: PubMed
      23. Bouziane M, Miao F, Bates SE, Somsouk L, Sang BC, Denissenko M, O'Connor TR. Promoter structure and cell cycle dependent expression of the human methylpurine-DNA glycosylase gene. Mutat Res. 2000 Sep 15; 461(1):15-29.
        View in: PubMed
      24. Frank G, Qiu J, Somsouk M, Weng Y, Somsouk L, Nolan JP, Shen B. Partial functional deficiency of E160D flap endonuclease-1 mutant in vitro and in vivo is due to defective cleavage of DNA substrates. J Biol Chem. 1998 Dec 4; 273(49):33064-72.
        View in: PubMed
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