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Valerie Weaver, PhD

TitleProfessor
SchoolUCSF School of Medicine
DepartmentSurgery
Address513 Parnassus Ave
San Francisco CA 94143
Phone415-476-3826
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    Collapse Research 
    Collapse Research Activities and Funding
    ECM geometrical and mechanical properties modulate RTK signaling
    NIH/NCI U01CA202241Sep 22, 2015 - Aug 31, 2020
    Role: Co-Principal Investigator
    2015 Fibronectin, Integrins &Related Molecules Gordon Research Conference &Gordon Research Seminar
    NIH/NIAMS R13AR068188May 1, 2015 - Apr 30, 2016
    Role: Principal Investigator
    Tension-Stat3-miR-mediated metastasis
    NIH/NCI R01CA192914Apr 1, 2015 - Mar 31, 2020
    Role: Co-Principal Investigator
    A biophysical stromal basis for radiation sensitivity in ductal carcinoma in situ
    NIH/NCI R01CA174929May 5, 2014 - Feb 28, 2019
    Role: Co-Principal Investigator
    Advanced Methods to Evaluate Extracellular Matrix and Crosslinking in the Tumor M
    NIH/NCI R33CA183685May 2, 2014 - Apr 30, 2017
    Role: Co-Principal Investigator
    2013 Fibronectin, Integrins &Related Molecules GRC/GRS
    NIH/NCI R13CA174204Feb 6, 2013 - Jan 31, 2014
    Role: Principal Investigator
    Biophysical and molecular dialogue of glioma cells and the brain microenvironment
    NIH/NCI U54CA163155Sep 26, 2011 - Jul 31, 2016
    Role: Co-Principal Investigator
    Role of Fibroblasts, Myeloid Cells and Matrix in PDAC
    NIH/NCI U01CA151925Sep 30, 2010 - Aug 31, 2015
    Role: Co-Principal Investigator
    Collagen remodeling and tumor progression
    NIH/NCI R01CA138818May 7, 2010 - Feb 28, 2015
    Role: Principal Investigator
    Fundamental Mechanobiology of Tumor Progression
    NIH U54CA143836Sep 29, 2009 - Jul 31, 2015
    Role: Co-Investigator
    NFkB, tissue polarity and apoptosis resistance
    NIH/NCI R01CA078731Jul 1, 2000 - Jun 30, 2010
    Role: Principal Investigator
    TGF-beta Suppression and Promotion of Mammary Carcinomas
    NIH/NCI R01CA085492May 20, 2000 - Feb 29, 2016
    Role: Co-Principal Investigator

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    Collapse Global Health
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Barnes JM, Przybyla L, Weaver VM. Tissue mechanics regulate brain development, homeostasis and disease. J Cell Sci. 2017 Jan 01; 130(1):71-82. PMID: 28043968.
      View in: PubMed
    2. Chang TT, Thakar D, Weaver VM. Force-dependent breaching of the basement membrane. Matrix Biol. 2016 Dec 23. PMID: 28025167.
      View in: PubMed
    3. Kaushik S, Pickup MW, Weaver VM. From transformation to metastasis: deconstructing the extracellular matrix in breast cancer. Cancer Metastasis Rev. 2016 Dec 02. PMID: 27914000.
      View in: PubMed
    4. Chan TS, Hsu CC, Pai VC, Liao WY, Huang SS, Tan KT, Yen CJ, Hsu SC, Chen WY, Shan YS, Li CR, Lee MT, Jiang KY, Chu JM, Lien GS, Weaver VM, Tsai KK. Metronomic chemotherapy prevents therapy-induced stromal activation and induction of tumor-initiating cells. J Exp Med. 2016 Nov 23. PMID: 27881732.
      View in: PubMed
    5. Miroshnikova YA, Mouw JK, Barnes JM, Pickup MW, Lakins JN, Kim Y, Lobo K, Persson AI, Reis GF, McKnight TR, Holland EC, Phillips JJ, Weaver VM. Tissue mechanics promote IDH1-dependent HIF1a-tenascin C feedback to regulate glioblastoma aggression. Nat Cell Biol. 2016 Nov 07. PMID: 27820599.
      View in: PubMed
    6. Takai K, Le A, Weaver VM, Werb Z. Targeting the cancer-associated fibroblasts as a treatment in triple-negative breast cancer. Oncotarget. 2016 Oct 14. PMID: 27756881.
      View in: PubMed
    7. Przybyla L, Lakins JN, Weaver VM. Tissue Mechanics Orchestrate Wnt-Dependent Human Embryonic Stem Cell Differentiation. Cell Stem Cell. 2016 Oct 6; 19(4):462-475. PMID: 27452175.
      View in: PubMed
    8. Ou G, Thakar D, Tung JC, Miroshnikova YA, Dufort CC, Gutierrez E, Groisman A, Weaver V. Visualizing mechanical modulation of nanoscale organization of cell-matrix adhesions. Integr Biol (Camb). 2016 Jul 11; 8(7):795-804. PMID: 27334548.
      View in: PubMed
    9. Przybyla L, Muncie JM, Weaver VM. Mechanical Control of Epithelial-to-Mesenchymal Transitions in Development and Cancer. Annu Rev Cell Dev Biol. 2016 Oct 6; 32:527-554. PMID: 27298087.
      View in: PubMed
    10. Bhagawati M, Rubashkin MG, Lee JP, Ananthanarayanan B, Weaver VM, Kumar S. Site-Specific Modulation of Charge Controls the Structure and Stimulus Responsiveness of Intrinsically Disordered Peptide Brushes. Langmuir. 2016 Jun 14; 32(23):5990-6. PMID: 27203736.
      View in: PubMed
    11. Laklai H, Miroshnikova YA, Pickup MW, Collisson EA, Kim GE, Barrett AS, Hill RC, Lakins JN, Schlaepfer DD, Mouw JK, LeBleu VS, Roy N, Novitskiy SV, Johansen JS, Poli V, Kalluri R, Iacobuzio-Donahue CA, Wood LD, Hebrok M, Hansen K, Moses HL, Weaver V. Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression. Nat Med. 2016 May; 22(5):497-505. PMID: 27089513.
      View in: PubMed
    12. Kai F, Laklai H, Weaver VM. Force Matters: Biomechanical Regulation of Cell Invasion and Migration in Disease. Trends Cell Biol. 2016 Jul; 26(7):486-97. PMID: 27056543.
      View in: PubMed
    13. Le LT, Cazares O, Mouw JK, Chatterjee S, Macias H, Moran A, Ramos J, Keely PJ, Weaver VM, Hinck L. Loss of miR-203 regulates cell shape and matrix adhesion through ROBO1/Rac/FAK in response to stiffness. J Cell Biol. 2016 Mar 14; 212(6):707-19. PMID: 26975850.
      View in: PubMed
    14. Desai SS, Tung JC, Zhou VX, Grenert JP, Malato Y, Rezvani M, Español-Suñer R, Willenbring H, Weaver V, Chang TT. Physiological ranges of matrix rigidity modulate primary mouse hepatocyte function in part through hepatocyte nuclear factor 4 alpha. Hepatology. 2016 Jul; 64(1):261-75. PMID: 26755329.
      View in: PubMed
    15. Ou G, Weaver VM. Tumor-induced solid stress activates ß-catenin signaling to drive malignant behavior in normal, tumor-adjacent cells. Bioessays. 2015 Dec; 37(12):1293-7. PMID: 26439949.
      View in: PubMed
    16. Lin CH, Pelissier FA, Zhang H, Lakins J, Weaver VM, Park C, LaBarge MA. Microenvironment rigidity modulates responses to the HER2 receptor tyrosine kinase inhibitor lapatinib via YAP and TAZ transcription factors. Mol Biol Cell. 2015 Nov 5; 26(22):3946-53. PMID: 26337386.
      View in: PubMed
    17. Przybyla L, Lakins JN, Sunyer R, Trepat X, Weaver VM. Monitoring developmental force distributions in reconstituted embryonic epithelia. Methods. 2016 Feb 1; 94:101-13. PMID: 26342256.
      View in: PubMed
    18. Lau J, Ilkhanizadeh S, Wang S, Miroshnikova YA, Salvatierra NA, Wong RA, Schmidt C, Weaver VM, Weiss WA, Persson AI. STAT3 Blockade Inhibits Radiation-Induced Malignant Progression in Glioma. Cancer Res. 2015 Oct 15; 75(20):4302-11. PMID: 26282165; PMCID: PMC4609277 [Available on 10/15/16].
    19. Acerbi I, Cassereau L, Dean I, Shi Q, Au A, Park C, Chen YY, Liphardt J, Hwang ES, Weaver V. Human breast cancer invasion and aggression correlates with ECM stiffening and immune cell infiltration. Integr Biol (Camb). 2015 Oct 5; 7(10):1120-34. PMID: 25959051; PMCID: PMC4593730.
    20. Northcott JM, Northey JJ, Barnes JM, Weaver VM. Fighting the force: Potential of homeobox genes for tumor microenvironment regulation. Biochim Biophys Acta. 2015 Apr; 1855(2):248-53. PMID: 25818365; PMCID: PMC4433566 [Available on 04/01/16].
    21. Tung JC, Barnes JM, Desai SR, Sistrunk C, Conklin MW, Schedin P, Eliceiri KW, Keely PJ, Seewaldt VL, Weaver VM. Tumor mechanics and metabolic dysfunction. Free Radic Biol Med. 2015 Feb; 79:269-80. PMID: 25532934; PMCID: PMC4339308 [Available on 02/01/16].
    22. Cassereau L, Miroshnikova YA, Ou G, Lakins J, Weaver VM. A 3D tension bioreactor platform to study the interplay between ECM stiffness and tumor phenotype. J Biotechnol. 2015 Jan 10; 193:66-9. PMID: 25435379; PMCID: PMC4454500.
    23. Pickup MW, Mouw JK, Weaver VM. The extracellular matrix modulates the hallmarks of cancer. EMBO Rep. 2014 Dec; 15(12):1243-53. PMID: 25381661; PMCID: PMC4264927.
    24. Mouw JK, Ou G, Weaver VM. Extracellular matrix assembly: a multiscale deconstruction. Nat Rev Mol Cell Biol. 2014 Dec; 15(12):771-85. PMID: 25370693.
      View in: PubMed
    25. Weaver VM. The microenvironment matters. Mol Biol Cell. 2014 Nov 1; 25(21):3254-8. PMID: 25360044; PMCID: PMC4214768.
    26. Rubashkin MG, Cassereau L, Bainer R, DuFort CC, Yui Y, Ou G, Paszek MJ, Davidson MW, Chen YY, Weaver VM. Force engages vinculin and promotes tumor progression by enhancing PI3K activation of phosphatidylinositol (3,4,5)-triphosphate. Cancer Res. 2014 Sep 1; 74(17):4597-611. PMID: 25183785; PMCID: PMC4191931.
    27. Venugopalan G, Camarillo DB, Webster KD, Reber CD, Sethian JA, Weaver VM, Fletcher DA, El-Samad H, Rycroft CH. Multicellular architecture of malignant breast epithelia influences mechanics. PLoS One. 2014; 9(8):e101955. PMID: 25111489; PMCID: PMC4128597.
    28. Paszek MJ, DuFort CC, Rossier O, Bainer R, Mouw JK, Godula K, Hudak JE, Lakins JN, Wijekoon AC, Cassereau L, Rubashkin MG, Magbanua MJ, Thorn KS, Davidson MW, Rugo HS, Park JW, Hammer DA, Giannone G, Bertozzi CR, Weaver VM. The cancer glycocalyx mechanically primes integrin-mediated growth and survival. Nature. 2014 Jul 17; 511(7509):319-25. PMID: 25030168; PMCID: PMC4487551.
    29. Özdemir BC, Pentcheva-Hoang T, Carstens JL, Zheng X, Wu CC, Simpson TR, Laklai H, Sugimoto H, Kahlert C, Novitskiy SV, De Jesus-Acosta A, Sharma P, Heidari P, Mahmood U, Chin L, Moses HL, Weaver VM, Maitra A, Allison JP, LeBleu VS, Kalluri R. Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival. Cancer Cell. 2014 Jun 16; 25(6):719-34. PMID: 24856586; PMCID: PMC4180632.
    30. Michor F, Weaver VM. Understanding tissue context influences on intratumour heterogeneity. Nat Cell Biol. 2014 Apr; 16(4):301-2. PMID: 24691256; PMCID: PMC4180082.
    31. Rubashkin MG, Ou G, Weaver VM. Deconstructing signaling in three dimensions. Biochemistry. 2014 Apr 8; 53(13):2078-90. PMID: 24649923; PMCID: PMC3985742.
    32. Mouw JK, Yui Y, Damiano L, Bainer RO, Lakins JN, Acerbi I, Ou G, Wijekoon AC, Levental KR, Gilbert PM, Hwang ES, Chen YY, Weaver VM. Tissue mechanics modulate microRNA-dependent PTEN expression to regulate malignant progression. Nat Med. 2014 Apr; 20(4):360-7. PMID: 24633304; PMCID: PMC3981899.
    33. Shi Q, Ghosh RP, Engelke H, Rycroft CH, Cassereau L, Sethian JA, Weaver VM, Liphardt JT. Rapid disorganization of mechanically interacting systems of mammary acini. Proc Natl Acad Sci U S A. 2014 Jan 14; 111(2):658-63. PMID: 24379367; PMCID: PMC3896145.
    34. Bainer R, Weaver V. Cell biology. Strength under tension. Science. 2013 Aug 30; 341(6149):965-6. PMID: 23990548.
      View in: PubMed
    35. Pickup MW, Laklai H, Acerbi I, Owens P, Gorska AE, Chytil A, Aakre M, Weaver VM, Moses HL. Stromally derived lysyl oxidase promotes metastasis of transforming growth factor-ß-deficient mouse mammary carcinomas. Cancer Res. 2013 Sep 1; 73(17):5336-46. PMID: 23856251; PMCID: PMC3766496.
    36. Maller O, Hansen KC, Lyons TR, Acerbi I, Weaver VM, Prekeris R, Tan AC, Schedin P. Collagen architecture in pregnancy-induced protection from breast cancer. J Cell Sci. 2013 Sep 15; 126(Pt 18):4108-10. PMID: 23843613; PMCID: PMC3772386.
    37. Damiano L, Stewart KM, Cohet N, Mouw JK, Lakins JN, Debnath J, Reisman D, Nickerson JA, Imbalzano AN, Weaver VM. Oncogenic targeting of BRM drives malignancy through C/EBPß-dependent induction of a5 integrin. Oncogene. 2014 May 8; 33(19):2441-53. PMID: 23770848; PMCID: PMC3960370.
    38. Maller O, DuFort CC, Weaver VM. YAP forces fibroblasts to feel the tension. Nat Cell Biol. 2013 Jun; 15(6):570-2. PMID: 23728464.
      View in: PubMed
    39. Tang Y, Rowe RG, Botvinick EL, Kurup A, Putnam AJ, Seiki M, Weaver VM, Keller ET, Goldstein S, Dai J, Begun D, Saunders T, Weiss SJ. MT1-MMP-dependent control of skeletal stem cell commitment via a ß1-integrin/YAP/TAZ signaling axis. Dev Cell. 2013 May 28; 25(4):402-16. PMID: 23685250; PMCID: PMC3736823.
    40. Agus DB, Alexander JF, Arap W, Ashili S, Aslan JE, Austin RH, Backman V, Bethel KJ, Bonneau R, Chen WC, Chen-Tanyolac C, Choi NC, Curley SA, Dallas M, Damania D, Davies PC, Decuzzi P, Dickinson L, Estevez-Salmeron L, Estrella V, Ferrari M, Fischbach C, Foo J, Fraley SI, Frantz C, Fuhrmann A, Gascard P, Gatenby RA, Geng Y, Gerecht S, Gillies RJ, Godin B, Grady WM, Greenfield A, Hemphill C, Hempstead BL, Hielscher A, Hillis WD, Holland EC, Ibrahim-Hashim A, Jacks T, Johnson RH, Joo A, Katz JE, Kelbauskas L, Kesselman C, King MR, Konstantopoulos K, Kraning-Rush CM, Kuhn P, Kung K, Kwee B, Lakins JN, Lambert G, Liao D, Licht JD, Liphardt JT, Liu L, Lloyd MC, Lyubimova A, Mallick P, Marko J, McCarty OJ, Meldrum DR, Michor F, Mumenthaler SM, Nandakumar V, O'Halloran TV, Oh S, Pasqualini R, Paszek MJ, Philips KG, Poultney CS, Rana K, Reinhart-King CA, Ros R, Semenza GL, Senechal P, Shuler ML, Srinivasan S, Staunton JR, Stypula Y, Subramanian H, Tlsty TD, Tormoen GW, Tseng Y, van Oudenaarden A, Verbridge SS, Wan JC, Weaver VM, Widom J, Will C, Wirtz D, Wojtkowiak J, Wu PH. A physical sciences network characterization of non-tumorigenic and metastatic cells. Sci Rep. 2013; 3:1449. PMID: 23618955; PMCID: PMC3636513.
    41. Li CR, Su JJ, Wang WY, Lee MT, Wang TY, Jiang KY, Li CF, Hsu JM, Chen CK, Chen M, Jiang SS, Weaver VM, Tsai KK. Molecular profiling of prostatic acinar morphogenesis identifies PDCD4 and KLF6 as tissue architecture-specific prognostic markers in prostate cancer. Am J Pathol. 2013 Feb; 182(2):363-74. PMID: 23219426; PMCID: PMC3562735.
    42. Paszek MJ, DuFort CC, Rubashkin MG, Davidson MW, Thorn KS, Liphardt JT, Weaver VM. Scanning angle interference microscopy reveals cell dynamics at the nanoscale. Nat Methods. 2012 Aug; 9(8):825-7. PMID: 22751201; PMCID: PMC3454456.
    43. Cassereau L, DuFort CC, Weaver VM. Morphogenesis: Laying down the tracks. Nat Mater. 2012 Jun; 11(6):490-2. PMID: 22614514.
      View in: PubMed
    44. Lu P, Weaver VM, Werb Z. The extracellular matrix: a dynamic niche in cancer progression. J Cell Biol. 2012 Feb 20; 196(4):395-406. PMID: 22351925; PMCID: PMC3283993.
    45. Lakins JN, Chin AR, Weaver VM. Exploring the link between human embryonic stem cell organization and fate using tension-calibrated extracellular matrix functionalized polyacrylamide gels. Methods Mol Biol. 2012; 916:317-50. PMID: 22914951.
      View in: PubMed
    46. Lu P, Takai K, Weaver VM, Werb Z. Extracellular matrix degradation and remodeling in development and disease. Cold Spring Harb Perspect Biol. 2011 Dec; 3(12). PMID: 21917992; PMCID: PMC3225943.
    47. Lopez JI, Kang I, You WK, McDonald DM, Weaver VM. In situ force mapping of mammary gland transformation. Integr Biol (Camb). 2011 Sep; 3(9):910-21. PMID: 21842067; PMCID: PMC3564969.
    48. Samuel MS, Lopez JI, McGhee EJ, Croft DR, Strachan D, Timpson P, Munro J, Schröder E, Zhou J, Brunton VG, Barker N, Clevers H, Sansom OJ, Anderson KI, Weaver VM, Olson MF. Actomyosin-mediated cellular tension drives increased tissue stiffness and ß-catenin activation to induce epidermal hyperplasia and tumor growth. Cancer Cell. 2011 Jun 14; 19(6):776-91. PMID: 21665151; PMCID: PMC3115541.
    49. Weaver V. Valerie Weaver: overcoming cancer's stiff resistance. Interview by Caitlin Sedwick. J Cell Biol. 2011 May 30; 193(5):802-3. PMID: 21624950; PMCID: PMC3105548.
    50. DuFort CC, Paszek MJ, Weaver VM. Balancing forces: architectural control of mechanotransduction. Nat Rev Mol Cell Biol. 2011 May; 12(5):308-19. PMID: 21508987; PMCID: PMC3564968.
    51. Dvorak HF, Weaver VM, Tlsty TD, Bergers G. Tumor microenvironment and progression. J Surg Oncol. 2011 May 1; 103(6):468-74. PMID: 21480238; PMCID: PMC3277953.
    52. Miroshnikova YA, Jorgens DM, Spirio L, Auer M, Sarang-Sieminski AL, Weaver VM. Engineering strategies to recapitulate epithelial morphogenesis within synthetic three-dimensional extracellular matrix with tunable mechanical properties. Phys Biol. 2011 Apr; 8(2):026013. PMID: 21441648; PMCID: PMC3401181.
    53. Frantz C, Stewart KM, Weaver VM. The extracellular matrix at a glance. J Cell Sci. 2010 Dec 15; 123(Pt 24):4195-200. PMID: 21123617; PMCID: PMC2995612.
    54. Yu H, Mouw JK, Weaver VM. Forcing form and function: biomechanical regulation of tumor evolution. Trends Cell Biol. 2011 Jan; 21(1):47-56. PMID: 20870407; PMCID: PMC3014395.
    55. Brown XQ, Bartolak-Suki E, Williams C, Walker ML, Weaver VM, Wong JY. Effect of substrate stiffness and PDGF on the behavior of vascular smooth muscle cells: implications for atherosclerosis. J Cell Physiol. 2010 Oct; 225(1):115-22. PMID: 20648629; PMCID: PMC2920297.
    56. Egeblad M, Rasch MG, Weaver VM. Dynamic interplay between the collagen scaffold and tumor evolution. Curr Opin Cell Biol. 2010 Oct; 22(5):697-706. PMID: 20822891; PMCID: PMC2948601.
    57. Cohet N, Stewart KM, Mudhasani R, Asirvatham AJ, Mallappa C, Imbalzano KM, Weaver VM, Imbalzano AN, Nickerson JA. SWI/SNF chromatin remodeling enzyme ATPases promote cell proliferation in normal mammary epithelial cells. J Cell Physiol. 2010 Jun; 223(3):667-78. PMID: 20333683; PMCID: PMC3320666.
    58. Gilbert PM, Mouw JK, Unger MA, Lakins JN, Gbegnon MK, Clemmer VB, Benezra M, Licht JD, Boudreau NJ, Tsai KK, Welm AL, Feldman MD, Weber BL, Weaver VM. HOXA9 regulates BRCA1 expression to modulate human breast tumor phenotype. J Clin Invest. 2010 May; 120(5):1535-50. PMID: 20389018; PMCID: PMC2860938.
    59. Paszek M, Weaver V. Biophysics. Enforcing order on signaling. Science. 2010 Mar 12; 327(5971):1335-6. PMID: 20223974.
      View in: PubMed
    60. Paszek MJ, Boettiger D, Weaver VM, Hammer DA. Integrin clustering is driven by mechanical resistance from the glycocalyx and the substrate. PLoS Comput Biol. 2009 Dec; 5(12):e1000604. PMID: 20011123; PMCID: PMC2782178.
    61. Levental KR, Yu H, Kass L, Lakins JN, Egeblad M, Erler JT, Fong SF, Csiszar K, Giaccia A, Weninger W, Yamauchi M, Gasser DL, Weaver VM. Matrix crosslinking forces tumor progression by enhancing integrin signaling. Cell. 2009 Nov 25; 139(5):891-906. PMID: 19931152; PMCID: PMC2788004.
    62. Kumar S, Weaver VM. Mechanics, malignancy, and metastasis: the force journey of a tumor cell. Cancer Metastasis Rev. 2009 Jun; 28(1-2):113-27. PMID: 19153673; PMCID: PMC2658728.
    63. Gehler S, Baldassarre M, Lad Y, Leight JL, Wozniak MA, Riching KM, Eliceiri KW, Weaver VM, Calderwood DA, Keely PJ. Filamin A-beta1 integrin complex tunes epithelial cell response to matrix tension. Mol Biol Cell. 2009 Jul; 20(14):3224-38. PMID: 19458194; PMCID: PMC2710838.
    64. Hansma P, Yu H, Schultz D, Rodriguez A, Yurtsev EA, Orr J, Tang S, Miller J, Wallace J, Zok F, Li C, Souza R, Proctor A, Brimer D, Nogues-Solan X, Mellbovsky L, Peña MJ, Diez-Ferrer O, Mathews P, Randall C, Kuo A, Chen C, Peters M, Kohn D, Buckley J, Li X, Pruitt L, Diez-Perez A, Alliston T, Weaver V, Lotz J. The tissue diagnostic instrument. Rev Sci Instrum. 2009 May; 80(5):054303. PMID: 19485522; PMCID: PMC2832056.
    65. Engler AJ, Humbert PO, Wehrle-Haller B, Weaver VM. Multiscale modeling of form and function. Science. 2009 Apr 10; 324(5924):208-12. PMID: 19359578; PMCID: PMC4527531.
    66. Vasilatos SN, Broadwater G, Barry WT, Baker JC, Lem S, Dietze EC, Bean GR, Bryson AD, Pilie PG, Goldenberg V, Skaar D, Paisie C, Torres-Hernandez A, Grant TL, Wilke LG, Ibarra-Drendall C, Ostrander JH, D'Amato NC, Zalles C, Jirtle R, Weaver VM, Seewaldt VL. CpG island tumor suppressor promoter methylation in non-BRCA-associated early mammary carcinogenesis. Cancer Epidemiol Biomarkers Prev. 2009 Mar; 18(3):901-14. PMID: 19258476; PMCID: PMC2667866.
    67. Butcher DT, Alliston T, Weaver VM. A tense situation: forcing tumour progression. Nat Rev Cancer. 2009 Feb; 9(2):108-22. PMID: 19165226; PMCID: PMC2649117.
    68. Lopez JI, Mouw JK, Weaver VM. Biomechanical regulation of cell orientation and fate. Oncogene. 2008 Nov 24; 27(55):6981-93. PMID: 19029939; PMCID: PMC2648514.
    69. Erler JT, Weaver VM. Three-dimensional context regulation of metastasis. Clin Exp Metastasis. 2009; 26(1):35-49. PMID: 18814043; PMCID: PMC2648515.
    70. Rizki A, Weaver VM, Lee SY, Rozenberg GI, Chin K, Myers CA, Bascom JL, Mott JD, Semeiks JR, Grate LR, Mian IS, Borowsky AD, Jensen RA, Idowu MO, Chen F, Chen DJ, Petersen OW, Gray JW, Bissell MJ. A human breast cell model of preinvasive to invasive transition. Cancer Res. 2008 Mar 1; 68(5):1378-87. PMID: 18316601; PMCID: PMC2662716.
    71. Fournier AK, Campbell LE, Castagnino P, Liu WF, Chung BM, Weaver VM, Chen CS, Assoian RK. Rac-dependent cyclin D1 gene expression regulated by cadherin- and integrin-mediated adhesion. J Cell Sci. 2008 Jan 15; 121(Pt 2):226-33. PMID: 18187454; PMCID: PMC2662746.
    72. Hebner C, Weaver VM, Debnath J. Modeling morphogenesis and oncogenesis in three-dimensional breast epithelial cultures. Annu Rev Pathol. 2008; 3:313-39. PMID: 18039125.
      View in: PubMed
    73. Yee KL, Weaver VM, Hammer DA. Integrin-mediated signalling through the MAP-kinase pathway. IET Syst Biol. 2008 Jan; 2(1):8-15. PMID: 18248081.
      View in: PubMed
    74. Friedland JC, Lakins JN, Kazanietz MG, Chernoff J, Boettiger D, Weaver VM. alpha6beta4 integrin activates Rac-dependent p21-activated kinase 1 to drive NF-kappaB-dependent resistance to apoptosis in 3D mammary acini. J Cell Sci. 2007 Oct 15; 120(Pt 20):3700-12. PMID: 17911169.
      View in: PubMed
    75. Weaver V, Werb Z. G'rab'bing the microenvironment for invasion. Dev Cell. 2007 Oct; 13(4):462-3. PMID: 17925222.
      View in: PubMed
    76. Kass L, Erler JT, Dembo M, Weaver VM. Mammary epithelial cell: influence of extracellular matrix composition and organization during development and tumorigenesis. Int J Biochem Cell Biol. 2007; 39(11):1987-94. PMID: 17719831; PMCID: PMC2658720.
    77. Johnson KR, Leight JL, Weaver VM. Demystifying the effects of a three-dimensional microenvironment in tissue morphogenesis. Methods Cell Biol. 2007; 83:547-83. PMID: 17613324; PMCID: PMC2658721.
    78. Underwood JM, Imbalzano KM, Weaver VM, Fischer AH, Imbalzano AN, Nickerson JA. The ultrastructure of MCF-10A acini. J Cell Physiol. 2006 Jul; 208(1):141-8. PMID: 16607610.
      View in: PubMed
    79. Boudreau N, Weaver V. Forcing the third dimension. Cell. 2006 May 5; 125(3):429-31. PMID: 16678088.
      View in: PubMed
    80. Yan Y, Weaver VM, Blair IA. Analysis of protein expression during oxidative stress in breast epithelial cells using a stable isotope labeled proteome internal standard. J Proteome Res. 2005 Nov-Dec; 4(6):2007-14. PMID: 16335945.
      View in: PubMed
    81. Paszek MJ, Zahir N, Johnson KR, Lakins JN, Rozenberg GI, Gefen A, Reinhart-King CA, Margulies SS, Dembo M, Boettiger D, Hammer DA, Weaver VM. Tensional homeostasis and the malignant phenotype. Cancer Cell. 2005 Sep; 8(3):241-54. PMID: 16169468.
      View in: PubMed
    82. Yang C, Liu Y, Leskow FC, Weaver VM, Kazanietz MG. Rac-GAP-dependent inhibition of breast cancer cell proliferation by {beta}2-chimerin. J Biol Chem. 2005 Jul 1; 280(26):24363-70. PMID: 15863513.
      View in: PubMed
    83. Cowden Dahl KD, Robertson SE, Weaver VM, Simon MC. Hypoxia-inducible factor regulates alphavbeta3 integrin cell surface expression. Mol Biol Cell. 2005 Apr; 16(4):1901-12. PMID: 15689487; PMCID: PMC1073670.
    84. Yeung T, Georges PC, Flanagan LA, Marg B, Ortiz M, Funaki M, Zahir N, Ming W, Weaver V, Janmey PA. Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion. Cell Motil Cytoskeleton. 2005 Jan; 60(1):24-34. PMID: 15573414.
      View in: PubMed
    85. Paszek MJ, Weaver VM. The tension mounts: mechanics meets morphogenesis and malignancy. J Mammary Gland Biol Neoplasia. 2004 Oct; 9(4):325-42. PMID: 15838603.
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    86. Weaver VM, Gilbert P. Watch thy neighbor: cancer is a communal affair. J Cell Sci. 2004 Mar 15; 117(Pt 8):1287-90. PMID: 15020668.
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    87. Zahir N, Weaver VM. Death in the third dimension: apoptosis regulation and tissue architecture. Curr Opin Genet Dev. 2004 Feb; 14(1):71-80. PMID: 15108808.
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    88. Zahir N, Lakins JN, Russell A, Ming W, Chatterjee C, Rozenberg GI, Marinkovich MP, Weaver VM. Autocrine laminin-5 ligates alpha6beta4 integrin and activates RAC and NFkappaB to mediate anchorage-independent survival of mammary tumors. J Cell Biol. 2003 Dec 22; 163(6):1397-407. PMID: 14691145; PMCID: PMC2173718.
    89. Russell AJ, Fincher EF, Millman L, Smith R, Vela V, Waterman EA, Dey CN, Guide S, Weaver VM, Marinkovich MP. Alpha 6 beta 4 integrin regulates keratinocyte chemotaxis through differential GTPase activation and antagonism of alpha 3 beta 1 integrin. J Cell Sci. 2003 Sep 1; 116(Pt 17):3543-56. PMID: 12865436.
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    90. Unger M, Weaver VM. The tissue microenvironment as an epigenetic tumor modifier. Methods Mol Biol. 2003; 223:315-47. PMID: 12777739.
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    91. Bissell MJ, Radisky DC, Rizki A, Weaver VM, Petersen OW. The organizing principle: microenvironmental influences in the normal and malignant breast. Differentiation. 2002 Dec; 70(9-10):537-46. PMID: 12492495; PMCID: PMC2933198.
    92. Weaver VM, Lelièvre S, Lakins JN, Chrenek MA, Jones JC, Giancotti F, Werb Z, Bissell MJ. beta4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium. Cancer Cell. 2002 Sep; 2(3):205-16. PMID: 12242153; PMCID: PMC2788997.
    93. Weaver VM. Membrane-associated MMP regulators: novel cell adhesion tumor suppressor proteins? Dev Cell. 2002 Jan; 2(1):6-7. PMID: 11782309.
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    94. Chrenek MA, Wong P, Weaver VM. Tumour-stromal interactions. Integrins and cell adhesions as modulators of mammary cell survival and transformation. Breast Cancer Res. 2001; 3(4):224-9. PMID: 11434873; PMCID: PMC138686.
    95. Weaver VM, Buckley T, Groopman JD. Lack of specificity of trans,trans-muconic acid as a benzene biomarker after ingestion of sorbic acid-preserved foods. Cancer Epidemiol Biomarkers Prev. 2000 Jul; 9(7):749-55. PMID: 10919747.
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    96. Spancake KM, Anderson CB, Weaver VM, Matsunami N, Bissell MJ, White RL. E7-transduced human breast epithelial cells show partial differentiation in three-dimensional culture. Cancer Res. 1999 Dec 15; 59(24):6042-5. PMID: 10626787.
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    97. Guerra-Vladusic FK, Scott G, Weaver V, Vladusic EA, Tsai MS, Benz CC, Lupu R. Constitutive expression of Heregulin induces apoptosis in an erbB-2 overexpressing breast cancer cell line SKBr-3. Int J Oncol. 1999 Nov; 15(5):883-92. PMID: 10536169.
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    98. Weaver VM, Bissell MJ. Functional culture models to study mechanisms governing apoptosis in normal and malignant mammary epithelial cells. J Mammary Gland Biol Neoplasia. 1999 Apr; 4(2):193-201. PMID: 10426398; PMCID: PMC2933214.
    99. Bissell MJ, Weaver VM, Lelièvre SA, Wang F, Petersen OW, Schmeichel KL. Tissue structure, nuclear organization, and gene expression in normal and malignant breast. Cancer Res. 1999 Apr 1; 59(7 Suppl):1757-1763s; discussion 1763s-1764s. PMID: 10197593.
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    100. Wang F, Weaver VM, Petersen OW, Larabell CA, Dedhar S, Briand P, Lupu R, Bissell MJ. Reciprocal interactions between beta1-integrin and epidermal growth factor receptor in three-dimensional basement membrane breast cultures: a different perspective in epithelial biology. Proc Natl Acad Sci U S A. 1998 Dec 8; 95(25):14821-6. PMID: 9843973; PMCID: PMC24533.
    101. Lelièvre SA, Weaver VM, Nickerson JA, Larabell CA, Bhaumik A, Petersen OW, Bissell MJ. Tissue phenotype depends on reciprocal interactions between the extracellular matrix and the structural organization of the nucleus. Proc Natl Acad Sci U S A. 1998 Dec 8; 95(25):14711-6. PMID: 9843954; PMCID: PMC24514.
    102. Schmeichel KL, Weaver VM, Bissell MJ. Structural cues from the tissue microenvironment are essential determinants of the human mammary epithelial cell phenotype. J Mammary Gland Biol Neoplasia. 1998 Apr; 3(2):201-13. PMID: 10819528; PMCID: PMC2933208.
    103. Petersen OW, Rønnov-Jessen L, Weaver VM, Bissell MJ. Differentiation and cancer in the mammary gland: shedding light on an old dichotomy. Adv Cancer Res. 1998; 75:135-61. PMID: 9709809; PMCID: PMC3867313.
    104. Weaver VM, Petersen OW, Wang F, Larabell CA, Briand P, Damsky C, Bissell MJ. Reversion of the malignant phenotype of human breast cells in three-dimensional culture and in vivo by integrin blocking antibodies. J Cell Biol. 1997 Apr 7; 137(1):231-45. PMID: 9105051; PMCID: PMC2139858.
    105. Weaver VM, Roskelley CD. Extracellular matrix: the central regulator of cell and tissue homeostasis. Trends Cell Biol. 1997 Jan; 7(1):40-2. PMID: 17708898.
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    106. Weaver VM, Fischer AH, Peterson OW, Bissell MJ. The importance of the microenvironment in breast cancer progression: recapitulation of mammary tumorigenesis using a unique human mammary epithelial cell model and a three-dimensional culture assay. Biochem Cell Biol. 1996; 74(6):833-51. PMID: 9164652; PMCID: PMC2933195.
    107. Weaver VM, Carson CE, Walker PR, Chaly N, Lach B, Raymond Y, Brown DL, Sikorska M. Degradation of nuclear matrix and DNA cleavage in apoptotic thymocytes. J Cell Sci. 1996 Jan; 109 ( Pt 1):45-56. PMID: 8834789.
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    108. Lelièvre S, Weaver VM, Bissell MJ. Extracellular matrix signaling from the cellular membrane skeleton to the nuclear skeleton: a model of gene regulation. Recent Prog Horm Res. 1996; 51:417-32. PMID: 8701089; PMCID: PMC2937008.
    109. Weaver VM, Howlett AR, Langton-Webster B, Petersen OW, Bissell MJ. The development of a functionally relevant cell culture model of progressive human breast cancer. Semin Cancer Biol. 1995 Jun; 6(3):175-84. PMID: 7495986.
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