Scott Kogan, MD

Title(s)Professor, Laboratory Medicine
SchoolSchool of Medicine
Address513 Parnassus Avenue, MSB, #561A
San Francisco CA 94117
Phone415-514-0815
ORCID ORCID Icon0000-0002-2395-8479 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of California, San Francisco, CAM.D.1991 School of Medicine
    University of California, San Francisco, CA Residency 1994School of Medicine
    University of California, San Francisco, CA10/2020Diversity, Equity, and Inclusion Champion Training

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Impact of low IL-10 levels at birth and leukemia risk
    NIH R01CA185058Jun 1, 2014 - May 31, 2020
    Role: Co-Principal Investigator
    Impact of B-Cell Lineage on Progression of B-Acute Lymphoblastic Leukemia
    NIH R21CA173028Feb 1, 2013 - Jan 31, 2016
    Role: Co-Principal Investigator
    Center for Integrative Research on Childhood Leukemia and the Environment
    NIH P50ES018172Sep 25, 2009 - Jun 30, 2019
    Role: Co-Investigator
    Molecular Mechanisms of Leukemogenesis by PMLRAR alpha
    NIH R01CA095274Apr 1, 2002 - Jan 31, 2014
    Role: Principal Investigator
    PATHOGENESIS AND THERAPY OF ACUTE PROMYELOCYTIC LEUKEMIA
    NIH K08CA075986Feb 19, 1999 - Jan 31, 2004
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. LNK/SH2B3 as a novel driver in juvenile myelomonocytic leukemia. Haematologica. 2023 Dec 28. Wintering A, Hecht A, Meyer J, Wong EB, Hübner J, Abelson S, Feldman K, Kennedy VE, Peretz CAC, French DL, Maguire JA, Jobaliya C, Vasquez MR, Desai S, Dulman R, Nemecek E, Haines H, Hammad M, El Haddad A, Kogan SC, Abdullaev Z, Chehab FF, Tasian SK, Smith CC, Loh ML, Stieglitz E. PMID: 38152053.
      View in: PubMed   Mentions:    Fields:    
    2. Impact of pinworm infection on the development of murine B-cell leukemia/lymphoma in the presence and absence of ETV6::RUNX1. Haematologica. 2023 Dec 01; 108(12):3480-3484. Fitch BA, Situ J, Wiemels JL, Wiemels JL, Kogan SC, Zhou M. PMID: 37345483; PMCID: PMC10690896.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    3. Gene-Environment Analyses Reveal Novel Genetic Candidates with Prenatal Tobacco Exposure in Relation to Risk for Childhood Acute Lymphoblastic Leukemia. Cancer Epidemiol Biomarkers Prev. 2023 12 01; 32(12):1707-1715. Zhong C, Li S, Arroyo K, Morimoto LM, de Smith AJ, Metayer C, Ma X, Kogan SC, Gauderman WJ, Wiemels JL, Wiemels JL. PMID: 37773025.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCellsPHPublic Health
    4. Efficacy of the Allosteric MEK Inhibitor Trametinib in Relapsed and Refractory Juvenile Myelomonocytic Leukemia: A Report from the Children's Oncology Group. Blood. 2023 Nov 28; 142(Supplement 1):74. Stieglitz SE, Lee LA, Angus AS, Davis DC, Barkauskas BD, Hall HD, Kogan KS, Meyer MJ, Rhodes RS, Xuei XX, Shannon SK, Loh LM, Fox FE, Weigel WB. .
      View in: Publisher Site   Mentions:
    5. Genetic architecture of the acute and persistent immune cell response after radiation exposure. Cell Genom. 2023 Nov 08; 3(11):100422. He L, Zhong C, Chang H, Inman JL, Celniker SE, Ioakeim-Ioannidou M, Liu KX, Haas-Kogan D, MacDonald SM, Threadgill DW, Kogan SC, Mao JH, Snijders AM. PMID: 38020972; PMCID: PMC10667298.
      View in: PubMed   Mentions:
    6. The SWI/SNF chromatin-remodeling subunit DPF2 facilitates NRF2-dependent antiinflammatory and antioxidant gene expression. J Clin Invest. 2023 07 03; 133(13). Mas G, Man N, Nakata Y, Martinez-Caja C, Karl D, Beckedorff F, Tamiro F, Chen C, Duffort S, Itonaga H, Mookhtiar AK, Kunkalla K, Valencia AM, Collings CK, Kadoch C, Vega F, Kogan SC, Shiekhattar R, Morey L, Bilbao D, Nimer SD. PMID: 37200093; PMCID: PMC10313367.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    7. Dapsone-induced methemoglobinemia and hemolysis in a woman without G6PD deficiency presenting with idiopathic urticaria. Hematology. 2022 Dec; 27(1):1253-1258. Hu Y, Geere M, Awan M, Leavitt AD, Brown LE, Pearson HJ, Gandelman JS, Kogan SC. PMID: 36444994; PMCID: PMC9788447.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    8. Cytomegalovirus proteins, maternal pregnancy cytokines, and their impact on neonatal immune cytokine profiles and acute lymphoblastic leukemogenesis in children. Haematologica. 2022 09 01; 107(9):2266-2270. Wiemels JL, Wiemels JL, Wang R, Zhou M, Hansen H, Gallant R, Jung J, Mancuso N, De Smith AJ, Metayer C, Kogan SC, Ma X. PMID: 35638549; PMCID: PMC9425315.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    9. RASA2 ablation in T cells boosts antigen sensitivity and long-term function. Nature. 2022 09; 609(7925):174-182. Carnevale J, Shifrut E, Kale N, Nyberg WA, Blaeschke F, Chen YY, Li Z, Bapat SP, Diolaiti ME, O'Leary P, Vedova S, Belk J, Daniel B, Roth TL, Bachl S, Anido AA, Prinzing B, Ibañez-Vega J, Lange S, Haydar D, Luetke-Eversloh M, Born-Bony M, Hegde B, Kogan S, Feuchtinger T, Okada H, Satpathy AT, Shannon K, Gottschalk S, Eyquem J, Krenciute G, Ashworth A, Marson A. PMID: 36002574; PMCID: PMC9433322.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    10. Genomic Features of Interstitial Deletions of Chromosome 9q in Acute Myeloid Leukemia. Cytogenet Genome Res. 2022; 162(3):119-123. Qi Z, Wen KW, Ki A, Prakash S, Kogan S, Yu J. PMID: 35675801; PMCID: PMC9677869.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    11. Apixaban Concentrations in Routine Clinical Care of Older Adults With Nonvalvular Atrial Fibrillation. JACC Adv. 2022 Jun; 1(2). Thomas A, Fang MC, Kogan S, Hubbard CC, Friedman PN, Gong L, Klein TE, Nutescu EA, O'Brien TJ, Tuck M, Perera MA, Schwartz JB. PMID: 37961076; PMCID: PMC10643025.
      View in: PubMed   Mentions:
    12. Clinical characteristics of cytomegalovirus-positive pediatric acute lymphoblastic leukemia at diagnosis. Am J Hematol. 2022 06 01; 97(6):E198-E201. Gallant RE, Arroyo K, Bracci PM, Li S, Metayer C, Kogan SC, Wendt GA, Francis SS, de Smith AJ, Wiemels JL, Wiemels JL. PMID: 35285969.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    13. Decreased IL-10 accelerates B-cell leukemia/lymphoma in a mouse model of pediatric lymphoid leukemia. Blood Adv. 2022 01 08; 6(3):854-865. Fitch BA, Zhou M, Situ J, Surianarayanan S, Reeves MQ, Hermiston ML, Wiemels JL, Wiemels JL, Kogan SC. PMID: 34727170; PMCID: PMC8945291.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    14. Preventing Bleeding With Direct-Acting Oral Anticoagulants. J Am Coll Cardiol. 2021 10 19; 78(16):e127. Schwartz JB, Kogan SC, Fang MC. PMID: 34649705; PMCID: PMC10631742.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    15. Nf1 and Sh2b3 mutations cooperate in vivo in a mouse model of juvenile myelomonocytic leukemia. Blood Adv. 2021 09 28; 5(18):3587-3591. Morales CE, Stieglitz E, Kogan SC, Loh ML, Braun BS. PMID: 34464969; PMCID: PMC8945579.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    16. Cytokine Levels at Birth in Children Who Developed Acute Lymphoblastic Leukemia. Cancer Epidemiol Biomarkers Prev. 2021 08; 30(8):1526-1535. Whitehead TP, Wiemels JL, Wiemels JL, Zhou M, Kang AY, McCoy LS, Wang R, Fitch B, Petrick LM, Yano Y, Imani P, Rappaport SM, Dahl GV, Kogan SC, Ma X, Metayer C. PMID: 34078642; PMCID: PMC8338848.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansPHPublic Health
    17. Epigenetic Biomarkers of Prenatal Tobacco Smoke Exposure Are Associated with Gene Deletions in Childhood Acute Lymphoblastic Leukemia. Cancer Epidemiol Biomarkers Prev. 2021 08; 30(8):1517-1525. Xu K, Li S, Whitehead TP, Pandey P, Kang AY, Morimoto LM, Kogan SC, Metayer C, Wiemels JL, Wiemels JL, de Smith AJ. PMID: 34020997; PMCID: PMC8338876.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCellsPHPublic Health
    18. Anti-factor Xa activity assays of direct-acting oral anticoagulants during clinical care: An observational study. Res Pract Thromb Haemost. 2021 May; 5(4):e12528. Sukumar S, Cabero M, Tiu S, Fang MC, Kogan SC, Schwartz JB. PMID: 34013157; PMCID: PMC8114026.
      View in: PubMed   Mentions: 1  
    19. In utero and early-life exposure to thirdhand smoke causes profound changes to the immune system. Clin Sci (Lond). 2021 04 30; 135(8):1053-1063. Snijders AM, Zhou M, Whitehead TP, Fitch B, Pandey P, Hechmer A, Huang A, Schick SF, de Smith AJ, Olshen AB, Metayer C, Mao JH, Wiemels JL, Wiemels JL, Kogan SC. PMID: 33851706; PMCID: PMC8086195.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsPHPublic Health
    20. Trends in Acute Lymphoblastic Leukemia Incidence in the United States by Race/Ethnicity From 2000 to 2016. Am J Epidemiol. 2021 04 06; 190(4):519-527. Feng Q, de Smith AJ, Vergara-Lluri M, Muskens IS, McKean-Cowdin R, Kogan S, Brynes R, Wiemels JL, Wiemels JL. PMID: 33034340.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    21. PML-RARα: changing myeloid networks. Blood. 2021 03 18; 137(11):1439-1440. Kogan SC. PMID: 33734342.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    22. KrasP34R and KrasT58I mutations induce distinct RASopathy phenotypes in mice. JCI Insight. 2020 11 05; 5(21). Wong JC, Perez-Mancera PA, Huang TQ, Kim J, Grego-Bessa J, Del Pilar Alzamora M, Kogan SC, Sharir A, Keefe SH, Morales CE, Schanze D, Castel P, Hirose K, Huang GN, Zenker M, Sheppard D, Klein OD, Tuveson DA, Braun BS, Shannon K. PMID: 32990679; PMCID: PMC7710308.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    23. The Baf Subunit Dpf2 Regulates Resolution of Inflammation By Controlling Macrophage Differentiation Transcription Factor Networks. Blood. 2020 Nov 5; 136(Supplement 1):13-13. Mas Martin MG, Man MN, Karl KD, Martinez MC, Duffort DS, Itonaga IH, Mookhtiar MA, Bilbao BD, Kunkalla KK, Valencia VA, Collings CC, Kadoch KC, Vega VF, Kogan KS, Nimer NS. .
      View in: Publisher Site   Mentions:
    24. History of Early Childhood Infections and Acute Lymphoblastic Leukemia Risk Among Children in a US Integrated Health-Care System. Am J Epidemiol. 2020 10 01; 189(10):1076-1085. Morimoto LM, Kwan ML, Deosaransingh K, Munneke JR, Kang AY, Quesenberry C, Kogan S, de Smith AJ, Metayer C, Wiemels JL, Wiemels JL. PMID: 32322901; PMCID: PMC7670873.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    25. Human pediatric B-cell acute lymphoblastic leukemias can be classified as B-1 or B-2-like based on a minimal transcriptional signature. Exp Hematol. 2020 10; 90:65-71.e1. Fitch B, Roy R, Geng H, Montecino-Rodriguez E, Bengtsson H, Gaillard C, Hiam K, Casero D, Olshen AB, Dorshkind K, Kogan SC. PMID: 32946981; PMCID: PMC7606616.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    26. Abstract A105: Trends in acute lymphocytic leukemia (ALL) incidence in the US from 2000-2016. Cancer Epidemiology Biomarkers & Prevention. 2020 Jun 1; 29(6_Supplement_2):a105-a105. Feng FQ, Vergara-Lluri VM, Muskens MI, McKean-Cowdin MR, Kogan KS, Brynes BR, de Smith dA, Wiemels WJ. .
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    27. Genetic disruption of N-RasG12D palmitoylation perturbs hematopoiesis and prevents myeloid transformation in mice. Blood. 2020 05 14; 135(20):1772-1782. Zambetti NA, Firestone AJ, Remsberg JR, Huang BJ, Wong JC, Long AM, Predovic M, Suciu RM, Inguva A, Kogan SC, Haigis KM, Cravatt BF, Shannon K. PMID: 32219446; PMCID: PMC7225687.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    28. Abstract A23: A second site KrasG12D mutation that impairs PI3K binding rescues embryonic lethality, abrogates myeloproliferative disease, and delays lung tumorigenesis. Molecular Cancer Research. 2020 May 1; 18(5_Supplement):a23-a23. Wong WJ, Perez-Mancera PP, Kim KJ, Jen JK, Kogan KS, Firestone FA, Collisson CE, Tuveson TD, Shannon SK. .
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    29. Loss of glucocorticoid receptor expression mediates in vivo dexamethasone resistance in T-cell acute lymphoblastic leukemia. Leukemia. 2020 08; 34(8):2025-2037. Wandler AM, Huang BJ, Craig JW, Hayes K, Yan H, Meyer LK, Scacchetti A, Monsalve G, Dail M, Li Q, Wong JC, Weinberg O, Hasserjian RP, Kogan SC, Jonsson P, Yamamoto K, Sampath D, Nakitandwe J, Downing JR, Zhang J, Aster JC, Taylor BS, Shannon K. PMID: 32066867; PMCID: PMC7440098.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimals
    30. Increased neonatal level of arginase 2 in cases of childhood acute lymphoblastic leukemia implicates immunosuppression in the etiology. Haematologica. 2019 11; 104(11):e514-e516. Nielsen AB, Zhou M, de Smith AJ, Wang R, McCoy L, Hansen H, Morimoto L, Grønbæk K, Johansen C, Kogan SC, Metayer C, Bracci PM, Ma X, Wiemels JL, Wiemels JL. PMID: 30923090; PMCID: PMC6821599.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    31. FLT3-ITD impedes retinoic acid, but not arsenic, responses in murine acute promyelocytic leukemias. Blood. 2019 03 28; 133(13):1495-1506. Esnault C, Rahmé R, Rice KL, Berthier C, Gaillard C, Quentin S, Maubert AL, Kogan S, de Thé H. PMID: 30674471; PMCID: PMC6440296.
      View in: PubMed   Mentions: 24     Fields:    Translation:Animals
    32. Identification of IRF8 as a potent tumor suppressor in murine acute promyelocytic leukemia. Blood Adv. 2018 10 09; 2(19):2462-2466. Gaillard C, Surianarayanan S, Bentley T, Warr MR, Fitch B, Geng H, Passegué E, de Thé H, Kogan SC. PMID: 30266821; PMCID: PMC6177650.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    33. Dilute Russell viper venom time interpretation and clinical correlation: A two-year retrospective institutional review. Int J Lab Hematol. 2019 Feb; 41(1):80-86. Jacquot C, Wool GD, Kogan SC. PMID: 30194751.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    34. TCEA1 regulates the proliferative potential of mouse myeloid cells. Exp Cell Res. 2018 09 15; 370(2):551-560. Yang T, Cui H, Wen M, Zuber J, Kogan SC, Wei G. PMID: 30009791; PMCID: PMC6816334.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    35. Abstract 3241: Children with acute lymphoblastic leukemia have increased arginase 2 at birth, implicating immunosuppression in leukemogenesis. Epidemiology. 2018 Jul 1; 3241-3241. Nielsen NA, Zhou ZM, Smith SA, McCoy ML, Hansen HH, Bracci BP, Morimoto ML, Kogan KS, Metayer MC, Ma MX, Wiemels WJ. .
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    36. Severe Iron Metabolism Defects in Mice With Double Knockout of the Multicopper Ferroxidases Hephaestin and Ceruloplasmin. Cell Mol Gastroenterol Hepatol. 2018; 6(4):405-427. Fuqua BK, Lu Y, Frazer DM, Darshan D, Wilkins SJ, Dunn L, Loguinov AV, Kogan SC, Matak P, Chen H, Dunaief JL, Vulpe CD, Anderson GJ. PMID: 30182051; PMCID: PMC6120670.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    37. Age-Related Impaired Efficacy of Bone Marrow Cell Therapy for Myocardial Infarction Reflects a Decrease in B Lymphocytes. Mol Ther. 2018 07 05; 26(7):1685-1693. An S, Wang X, Ruck MA, Rodriguez HJ, Kostyushev DS, Varga M, Luu E, Derakhshandeh R, Suchkov SV, Kogan SC, Hermiston ML, Springer ML. PMID: 29914756; PMCID: PMC6036225.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    38. Dual origin of relapses in retinoic-acid resistant acute promyelocytic leukemia. Nat Commun. 2018 05 24; 9(1):2047. Lehmann-Che J, Bally C, Letouzé E, Berthier C, Yuan H, Jollivet F, Ades L, Cassinat B, Hirsch P, Pigneux A, Mozziconacci MJ, Kogan S, Fenaux P, de Thé H. PMID: 29795382; PMCID: PMC5967331.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimals
    39. Pml nuclear body disruption cooperates in APL pathogenesis and impairs DNA damage repair pathways in mice. Blood. 2018 02 08; 131(6):636-648. Voisset E, Moravcsik E, Stratford EW, Jaye A, Palgrave CJ, Hills RK, Salomoni P, Kogan SC, Solomon E, Grimwade D. PMID: 29191918; PMCID: PMC5805489.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    40. Acute myeloid leukemia with t(14;21) involving RUNX1 and SYNE2: A novel favorable-risk translocation? Cancer Genet. 2017 Oct; 216-217:74-78. Foley N, Van Ziffle J, Yu J, Qi Z, Grenert JP, Yeh I, Bastian B, Kogan S, Mannis GN. PMID: 29025598.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    41. In utero cytomegalovirus infection and development of childhood acute lymphoblastic leukemia. Blood. 2017 03 23; 129(12):1680-1684. Francis SS, Wallace AD, Wendt GA, Li L, Liu F, Riley LW, Kogan S, Walsh KM, de Smith AJ, Dahl GV, Ma X, Delwart E, Metayer C, Wiemels JL, Wiemels JL. PMID: 27979823; PMCID: PMC5364339.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansPHPublic Health
    42. Resistant T-Cell Acute Lymphoblastic Leukemias That Emerge after In Vivo Treatment with Dexamethasone Frequently Down-Regulate Glucocorticoid Receptor Protein Expression. Blood. 2016 Dec 2; 128(22):753-753. Wandler WA, Huang HB, Scacchetti SA, Craig CJ, Yan YH, Monsalve MG, Li LQ, Dail DM, Wong WJ, Nakitandwe NJ, Weinberg WO, Hasserjian HR, Kogan KS, Sampath SD, Downing DJ, Yamamoto YK, Taylor TB, Aster AJ, Zhang ZJ, Shannon SK. .
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    43. Mechanism of IL-10 Protective Effect in Development of Childhood B Cell Acute Lymphoblastic Leukemia. Blood. 2016 Dec 2; 128(22):4075-4075. Fitch FB, Hermiston HM, Wiemels WJ, Kogan KS. .
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    44. Dilute Russell Viper Venom Time Interpretation and Clinical Correlation: A Two-Year Retrospective Institutional Review. Blood. 2016 Dec 2; 128(22):2609-2609. Jacquot JC, Wool WG, Kogan KS. .
      View in: Publisher Site   Mentions:
    45. Identification of IRF8 As a Potent Tumor Suppressor in Murine Acute Promyelocytic Leukemia. Blood. 2016 Dec 2; 128(22):1518-1518. Surianarayanan SS, Gaillard GC, Bentley BT, Warr WM, Fitch FB, Geng GH, Passegue PE, de Thé dH, Kogan KS. .
      View in: Publisher Site   Mentions:
    46. Genetic Subtypes of Human Pediatric ALLs Show Gene Expression Differences That Parallel Those Observed in Mouse B1 and B2 Progenitors, Suggesting Divergent Developmental Origins. Blood. 2016 Dec 2; 128(22):1741-1741. Kogan KS, Geng GH, Roy RR, Montecino-Rodriguez ME, Gaillard GC, Hiam HK, Bengtsson BH, Casero CD, Olshen OA, Dorshkind DK. .
      View in: Publisher Site   Mentions:
    47. Pml Nuclear Body Disruption Cooperates in APL Pathogenesis, Impacting DNA Damage Repair Pathways. Blood. 2016 Dec 2; 128(22):742-742. Voisset VE, Moravcsik ME, Stratford SE, Jaye JA, Palgrave PC, Hills HR, Salomoni SP, Kogan KS, Solomon SE, Grimwade GD. .
      View in: Publisher Site   Mentions:
    48. Co-operative leukemogenesis in acute myeloid leukemia and acute promyelocytic leukemia reveals C/EBPα as a common target of TRIB1 and PML/RARA. Haematologica. 2016 10; 101(10):1228-1236. Keeshan K, Vieugué P, Chaudhury S, Rishi L, Gaillard C, Liang L, Garcia E, Nakamura T, Omidvar N, Kogan SC. PMID: 27390356; PMCID: PMC5046652.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    49. DNMT3A Haploinsufficiency Transforms FLT3ITD Myeloproliferative Disease into a Rapid, Spontaneous, and Fully Penetrant Acute Myeloid Leukemia. Cancer Discov. 2016 05; 6(5):501-15. Meyer SE, Qin T, Muench DE, Masuda K, Venkatasubramanian M, Orr E, Suarez L, Gore SD, Delwel R, Paietta E, Tallman MS, Fernandez H, Melnick A, Le Beau MM, Kogan S, Salomonis N, Figueroa ME, Grimes HL. PMID: 27016502; PMCID: PMC4861898.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    50. Sustained MEK inhibition abrogates myeloproliferative disease in Nf1 mutant mice. J Clin Invest. 2016 Jan; 126(1):404. Chang T, Krisman K, Theobald EH, Xu J, Akutagawa J, Lauchle JO, Kogan S, Braun BS, Shannon K. PMID: 26727232; PMCID: PMC4701564.
      View in: PubMed   Mentions: 2     Fields:    
    51. Functional evidence implicating chromosome 7q22 haploinsufficiency in myelodysplastic syndrome pathogenesis. Elife. 2015 Jul 20; 4. Wong JC, Weinfurtner KM, Alzamora Mdel P, Kogan SC, Burgess MR, Zhang Y, Nakitandwe J, Ma J, Cheng J, Chen SC, Ho TT, Flach J, Reynaud D, Passegué E, Downing JR, Shannon K. PMID: 26193121; PMCID: PMC4569895.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    52. Transcription and methylation analyses of preleukemic promyelocytes indicate a dual role for PML/RARA in leukemia initiation. Haematologica. 2015 Aug; 100(8):1064-75. Gaillard C, Tokuyasu TA, Rosen G, Sotzen J, Vitaliano-Prunier A, Roy R, Passegué E, de Thé H, Figueroa ME, Kogan SC. PMID: 26088929; PMCID: PMC5004423.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    53. Mechanisms of clonal evolution in childhood acute lymphoblastic leukemia. Nat Immunol. 2015 Jul; 16(7):766-774. Swaminathan S, Klemm L, Park E, Papaemmanuil E, Ford A, Kweon SM, Trageser D, Hasselfeld B, Henke N, Mooster J, Geng H, Schwarz K, Kogan SC, Casellas R, Schatz DG, Lieber MR, Greaves MF, Müschen M. PMID: 25985233; PMCID: PMC4475638.
      View in: PubMed   Mentions: 100     Fields:    Translation:HumansAnimalsCells
    54. Direct and indirect targeting of MYC to treat acute myeloid leukemia. Cancer Chemother Pharmacol. 2015 Jul; 76(1):35-46. Brondfield S, Umesh S, Corella A, Zuber J, Rappaport AR, Gaillard C, Lowe SW, Goga A, Kogan SC. PMID: 25956709; PMCID: PMC4485702.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    55. Cooperative loss of RAS feedback regulation drives myeloid leukemogenesis. Nat Genet. 2015 May; 47(5):539-43. Zhao Z, Chen CC, Rillahan CD, Shen R, Kitzing T, McNerney ME, Diaz-Flores E, Zuber J, Shannon K, Le Beau MM, Spector MS, Kogan SC, Lowe SW. PMID: 25822087; PMCID: PMC4414804.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    56. Preclinical Efficacy of MEK Inhibition in Nras Mutant Acute Myeloid Leukemia. Blood. 2014 Dec 6; 124(21):3753-3753. Burgess BM, Hwang HE, Firestone FA, Huang HT, Xu XJ, Zuber ZJ, Bohin BN, Wen WT, Kogan KS, Haigis HK, Lowe LS, Shannon SK, Li LQ. .
      View in: Publisher Site   Mentions:
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    121. Leukemia with distinct phenotypes in transgenic mice expressing PML/RAR alpha, PLZF/RAR alpha or NPM/RAR alpha. Oncogene. 2006 Mar 23; 25(13):1974-9. Rego EM, Ruggero D, Tribioli C, Cattoretti G, Kogan S, Redner RL, Pandolfi PP. PMID: 16331271.
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    122. Increased CCAAT enhancer-binding protein epsilon (C/EBPepsilon) expression and premature apoptosis in myeloid cells expressing Gfi-1 N382S mutant associated with severe congenital neutropenia. J Biol Chem. 2006 Apr 21; 281(16):10745-51. Zhuang D, Qiu Y, Kogan SC, Dong F. PMID: 16500901.
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    123. Forced retinoic acid receptor alpha homodimers prime mice for APL-like leukemia. Cancer Cell. 2006 Feb; 9(2):81-94. Sternsdorf T, Phan VT, Maunakea ML, Ocampo CB, Sohal J, Silletto A, Galimi F, Le Beau MM, Evans RM, Kogan SC. PMID: 16473276.
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    124. Cbf beta-SMMHC induces distinct abnormal myeloid progenitors able to develop acute myeloid leukemia. Cancer Cell. 2006 Jan; 9(1):57-68. Kuo YH, Landrette SF, Heilman SA, Perrat PN, Garrett L, Liu PP, Le Beau MM, Kogan SC, Castilla LH. PMID: 16413472.
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    125. Investigation of Hematopoietic Stem Cell and Progenitor Populations: Implication for Cell Fate Determination and Lineage Commitment. Blood. 2005 Nov 16; 106(11):801-801. Passegue PE, Forsberg FC, Serwold ST, Kogan KS, Weissman WI. .
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    126. Haploinsufficiency of Runx1/AML1 promotes myeloid features and leukaemogenesis in BXH2 mice. Br J Haematol. 2005 Nov; 131(4):495-507. Yamashita N, Osato M, Huang L, Yanagida M, Kogan SC, Iwasaki M, Nakamura T, Shigesada K, Asou N, Ito Y. PMID: 16281942.
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    127. Opinion: how patients have benefited from mouse models of acute promyelocytic leukaemia. Nat Rev Cancer. 2005 10; 5(10):821-7. Lallemand-Breitenbach V, Zhu J, Kogan S, Chen Z, de Thé H. PMID: 16175176.
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    128. Therapy-induced malignant neoplasms in Nf1 mutant mice. Cancer Cell. 2005 Oct; 8(4):337-48. Chao RC, Pyzel U, Fridlyand J, Kuo YM, Teel L, Haaga J, Borowsky A, Horvai A, Kogan SC, Bonifas J, Huey B, Jacks TE, Albertson DG, Shannon KM. PMID: 16226708.
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    129. Induction of tumor arrest and differentiation with prolonged survival by intermittent hypoxia in a mouse model of acute myeloid leukemia. Blood. 2006 Jan 15; 107(2):698-707. Liu W, Guo M, Xu YB, Li D, Zhou ZN, Wu YL, Chen Z, Kogan SC, Chen GQ. PMID: 16166593.
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    130. Role of O6-alkylguanine-DNA alkyltransferase in protecting against 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU)-induced long-term toxicities. J Pharmacol Exp Ther. 2005 Dec; 315(3):1247-55. Hansen RJ, Nagasubramanian R, Delaney SM, Cherian MM, Lin S, Kogan SC, Dolan ME. PMID: 16126841.
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    131. Cooperation of Cytokine Signaling with Chimeric Transcription Factors in Leukemogenesis: PML-Retinoic Acid Receptor Alpha Blocks Growth Factor-Mediated Differentiation. Molecular and Cellular Biology. 2005 Jul 1; 25(13):5787-5787. Phan PV, Shultz SD, Truong TB, Blake BT, Brown BA, Gonda GT, Le Beau LM, Kogan KS. .
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    132. A sumoylation site in PML/RARA is essential for leukemic transformation. Cancer Cell. 2005 Feb; 7(2):143-53. Zhu J, Zhou J, Peres L, Riaucoux F, Honoré N, Kogan S, de Thé H. PMID: 15710327.
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    133. Conditional MLL-CBP targets GMP and models therapy-related myeloproliferative disease. EMBO J. 2005 Jan 26; 24(2):368-81. Wang J, Iwasaki H, Krivtsov A, Febbo PG, Thorner AR, Ernst P, Anastasiadou E, Kutok JL, Kogan SC, Zinkel SS, Fisher JK, Hess JL, Golub TR, Armstrong SA, Akashi K, Korsmeyer SJ. PMID: 15635450; PMCID: PMC545811.
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    134. O-14 A reversible two-step model ofMDS/preleukemia: Transgenic mice expressing inducible BCL2 and mutant NRAS. Leukemia Research. 2005 Jan 1; 29:s5. Padua PR, Omidvar ON, Kogan KS, Phan PT, West WR, Felsher FD, Weissmann WI, Thomas TS, Whittaker WJ, Janin JA, Pla PM, Muftis MG, Bishop BJ, Chomienne CC. .
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    135. Discovery of Genes Involved in Experimental Pre-Leukemia to Leukemia Transition in Mice Using Expression Arrays. Blood. 2004 Nov 16; 104(11):1109-1109. Entin EI, Kogan KS. .
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    136. Cbfb-MYH11 Induces Expansion of a Lin-Kit+Sca1- Abnormal Progenitor Compartment that Predisposes Acute Myeloid Leukemia in Mice. Blood. 2004 Nov 16; 104(11):543-543. Kuo KY, Heilman HS, Chen CA, Liu LP, Gernstein GR, Kogan KS, Castilla CL. .
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    137. Identification of Cooperating Genetic Alterations in RUNX Leukemia Using the Mouse Model for the Human Familial Leukemia, FPD/AML. Blood. 2004 Nov 16; 104(11):3383-3383. Osato OM, Yamashita YN, Yanagida YM, Huang HL, Kogan KS, Iwasaki IM, Nakamura NT, Shigesada SK, Asou AN, Ito IY. .
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    138. Increased DNA Damage and Error-Prone Repair in MPD/MDS Mice with Disease Progression: Key Indicators for Increased Genomic Instability. Blood. 2004 Nov 16; 104(11):200-200. Rassool RF, Gaymes GT, Brady BN, Lea LN, Pla PM, Phan PT, Kogan KS, Chomienne CC, Thomas TN, Mafti MG, Padua PR. .
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    139. Cooperative Pathways to Acute Myeloid Leukemia Include the Combining of Transcription Factor Alterations: PML-RARa Cooperates with SOX4. Blood. 2004 Nov 16; 104(11):3385-3385. Kogan KS, Maunakea MM, Himmel HK, Yin YB, Le Beau LM, Largaespada LD. .
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    140. Homodimerization of Retinoic Acid Receptor alpha through its Fusion Partners Underlies Pathogenesis of Acute Promyelocytic Leukemia. Blood. 2004 Nov 16; 104(11):546-546. Kogan KS, Phan PV, Sternsdorf ST, Maunakea MM, Sohal SJ, Silletto SA, Galimi GF, Evans ER. .
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    141. HOXB6 overexpression in murine bone marrow immortalizes a myelomonocytic precursor in vitro and causes hematopoietic stem cell expansion and acute myeloid leukemia in vivo. Blood. 2005 Feb 15; 105(4):1456-66. Fischbach NA, Rozenfeld S, Shen W, Fong S, Chrobak D, Ginzinger D, Kogan SC, Radhakrishnan A, Le Beau MM, Largman C, Lawrence HJ. PMID: 15522959.
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    142. Myeloid Malignancies. Mouse Models of Human Cancer. 2004 Oct 15. Kogan KS. .
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    143. Mouse models of human cancers (part 3). Comp Med. 2004 Jun; 54(3):258-70. Borowsky AD, Munn RJ, Galvez JJ, Cardiff RD, Ward JM, Morse HC, Kogan SC, Aldape KD, Louis DN, Bosenberg MW. PMID: 15253271.
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    144. Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy. Nature. 2004 Mar 18; 428(6980):332-7. Wendel HG, De Stanchina E, Fridman JS, Malina A, Ray S, Kogan S, Cordon-Cardo C, Pelletier J, Lowe SW. PMID: 15029198.
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    145. Somatic inactivation of Nf1 in hematopoietic cells results in a progressive myeloproliferative disorder. Blood. 2004 Jun 01; 103(11):4243-50. Le DT, Kong N, Zhu Y, Lauchle JO, Aiyigari A, Braun BS, Wang E, Kogan SC, Le Beau MM, Parada L, Shannon KM. PMID: 14982883.
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    146. The role of p53 in suppression of KSHV cyclin-induced lymphomagenesis. Cancer Res. 2004 Jan 15; 64(2):581-9. Verschuren EW, Hodgson JG, Gray JW, Kogan S, Jones N, Evan GI. PMID: 14744772.
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    147. Somatic activation of oncogenic Kras in hematopoietic cells initiates a rapidly fatal myeloproliferative disorder. Proc Natl Acad Sci U S A. 2004 Jan 13; 101(2):597-602. Braun BS, Tuveson DA, Kong N, Le DT, Kogan SC, Rozmus J, Le Beau MM, Jacks TE, Shannon KM. PMID: 14699048; PMCID: PMC327193.
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    148. PML-RARA-targeted DNA vaccine induces protective immunity in a mouse model of leukemia. Nat Med. 2003 Nov; 9(11):1413-7. Padua RA, Larghero J, Robin M, le Pogam C, Schlageter MH, Muszlak S, Fric J, West R, Rousselot P, Phan TH, Mudde L, Teisserenc H, Carpentier AF, Kogan S, Degos L, Pla M, Bishop JM, Stevenson F, Charron D, Chomienne C. PMID: 14566333.
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    149. A PMLRARA transgene results in a retinoid-deficient phenotype associated with enhanced susceptibility to skin tumorigenesis. Cancer Res. 2003 Sep 01; 63(17):5257-65. Hansen LA, Brown D, Virador V, Tanaka T, Andreola F, Strain K, Dancheck B, Riley R, Arbeit JM, De Luca LM, Kogan S, Yuspa SH. PMID: 14500356.
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    150. Cooperation of cytokine signaling with chimeric transcription factors in leukemogenesis: PML-retinoic acid receptor alpha blocks growth factor-mediated differentiation. Mol Cell Biol. 2003 Jul; 23(13):4573-85. Phan VT, Shultz DB, Truong BT, Blake TJ, Brown AL, Gonda TJ, Le Beau MM, Kogan SC. PMID: 12808098; PMCID: PMC164846.
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    151. Recurring chromosomal abnormalities in leukemia in PML-RARA transgenic mice identify cooperating events and genetic pathways to acute promyelocytic leukemia. Blood. 2003 Aug 01; 102(3):1072-4. Le Beau MM, Davis EM, Patel B, Phan VT, Sohal J, Kogan SC. PMID: 12689927.
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    152. A model of APL with FLT3 mutation is responsive to retinoic acid and a receptor tyrosine kinase inhibitor, SU11657. Blood. 2003 Apr 15; 101(8):3188-97. Sohal J, Phan VT, Chan PV, Davis EM, Patel B, Kelly LM, Abrams TJ, O'Farrell AM, Gilliland DG, Le Beau MM, Kogan SC. PMID: 12515727.
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    153. Bethesda proposals for classification of nonlymphoid hematopoietic neoplasms in mice. Blood. 2002 Jul 01; 100(1):238-45. Kogan SC, Ward JM, Anver MR, Berman JJ, Brayton C, Cardiff RD, Carter JS, de Coronado S, Downing JR, Fredrickson TN, Haines DC, Harris AW, Harris NL, Hiai H, Jaffe ES, MacLennan IC, Pandolfi PP, Pattengale PK, Perkins AS, Simpson RM, Tuttle MS, Wong JF, Morse HC, Hematopathology subcommittee of the Mouse Models of Human Cancers Consortium. PMID: 12070033.
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    154. Recurring chromosomal abnormalities in leukemia in PML-RARA transgenic mice parallel human acute promyelocytic leukemia. Blood. 2002 Apr 15; 99(8):2985-91. Le Beau MM, Bitts S, Davis EM, Kogan SC. PMID: 11929790.
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    155. Retroviral integration at the Epi1 locus cooperates with Nf1 gene loss in the progression to acute myeloid leukemia. J Virol. 2001 Oct; 75(19):9427-34. Blaydes SM, Kogan SC, Truong BT, Gilbert DJ, Jenkins NA, Copeland NG, Largaespada DA, Brannan CI. PMID: 11533205; PMCID: PMC114510.
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    156. Mouse intestinal goblet cells expressing SV40 T antigen directed by the MUC2 mucin gene promoter undergo apoptosis upon migration to the villi. Cancer Res. 2001 Apr 15; 61(8):3472-9. Gum JR, Hicks JW, Gillespie AM, Rius JL, Treseler PA, Kogan SC, Carlson EJ, Epstein CJ, Kim YS. PMID: 11309310.
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    157. BCL-2 cooperates with promyelocytic leukemia retinoic acid receptor alpha chimeric protein (PMLRARalpha) to block neutrophil differentiation and initiate acute leukemia. J Exp Med. 2001 Feb 19; 193(4):531-43. Kogan SC, Brown DE, Shultz DB, Truong BT, Lallemand-Breitenbach V, Guillemin MC, Lagasse E, Weissman IL, Bishop JM. PMID: 11181704; PMCID: PMC2195904.
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    158. Patient and clinician vocabulary: how different are they? Stud Health Technol Inform. 2001; 84(Pt 1):399-403. Zeng Q, Kogan S, Ash N, Greenes RA. PMID: 11604772.
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    159. Acute promyelocytic leukemia: a view from a mouse. Blood Cells Mol Dis. 2000 Dec; 26(6):620-5. Kogan SC. PMID: 11358354.
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    160. Leukemia initiated by PMLRARalpha: the PML domain plays a critical role while retinoic acid-mediated transactivation is dispensable. Blood. 2000 Mar 01; 95(5):1541-50. Kogan SC, Hong SH, Shultz DB, Privalsky ML, Bishop JM. PMID: 10688806.
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    161. Acute promyelocytic leukemia: from treatment to genetics and back. Oncogene. 1999 Sep 20; 18(38):5261-7. Kogan SC, Bishop JM. PMID: 10498878.
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    162. Images in clinical medicine. Indinavir crystalluria. N Engl J Med. 1999 Apr 29; 340(17):1329. Tsao JW, Kogan SC. PMID: 10219068.
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    163. Retinoic acid and arsenic synergize to eradicate leukemic cells in a mouse model of acute promyelocytic leukemia. J Exp Med. 1999 Apr 05; 189(7):1043-52. Lallemand-Breitenbach V, Guillemin MC, Janin A, Daniel MT, Degos L, Kogan SC, Bishop JM, de Thé H. PMID: 10190895; PMCID: PMC2193002.
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    164. The PEBP2betaMYH11 fusion created by Inv(16)(p13;q22) in myeloid leukemia impairs neutrophil maturation and contributes to granulocytic dysplasia. Proc Natl Acad Sci U S A. 1998 Sep 29; 95(20):11863-8. Kogan SC, Lagasse E, Atwater S, Bae SC, Weissman I, Ito Y, Bishop JM. PMID: 9751756; PMCID: PMC21731.
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    165. A PMLRARalpha transgene initiates murine acute promyelocytic leukemia. Proc Natl Acad Sci U S A. 1997 Mar 18; 94(6):2551-6. Brown D, Kogan S, Lagasse E, Weissman I, Alcalay M, Pelicci PG, Atwater S, Bishop JM. PMID: 9122233; PMCID: PMC20126.
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    166. 6 The effect of fractionated radiotherapy in glioblastoma depends on P53 function. International Journal of Radiation Oncology • Biology • Physics. 1996 Jan 1; 36(1):161. Haas-Kogan HD, Kogan KS, Yount YG, Hsu HJ, Dewey DW, Phillips PT, Israel IM. .
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    167. Inhibition of apoptosis by the retinoblastoma gene product. EMBO J. 1995 Feb 01; 14(3):461-72. Haas-Kogan DA, Kogan SC, Levi D, Dazin P, T'Ang A, Fung YK, Israel MA. PMID: 7859736; PMCID: PMC398104.
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    168. 157 P53-dependent G1 arrest and P53-independent apoptosis influence the radiobiologic response of glioblastoma. International Journal of Radiation Oncology • Biology • Physics. 1995 Jan 1; 32:219. Haas-Kogan HD, Yount YG, Haas HM, Levi LD, Kogan KS, Hu HL, Vidair VC, Deen DD, Dewey DW, Israel IM. .
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    169. Genitourinary malformations associated with agenesis of the corpus callosum. J Urol. 1993 May; 149(5):1119-21. Franco I, Kogan S, Fisher J, Rifkinson-Mann S, Reda E, Levitt S, Roseman B. PMID: 8483226.
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    170. Amino acid substitutions in conserved domains of factor VIII and related proteins: study of patients with mild and moderately severe hemophilia A. Hum Mutat. 1992; 1(3):248-57. Diamond C, Kogan S, Levinson B, Gitschier J. PMID: 1301932.
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    171. Genetic basis of hemophilia A. Thromb Haemost. 1991 Jul 12; 66(1):37-9. Gitschier J, Kogan S, Diamond C, Levinson B. PMID: 1926049.
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    172. Mutations and a polymorphism in the factor VIII gene discovered by denaturing gradient gel electrophoresis. Proc Natl Acad Sci U S A. 1990 Mar; 87(6):2092-6. Kogan S, Gitschier J. PMID: 2107542; PMCID: PMC53632.
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    173. 35 GENETIC PREDICTION OF HEMOPHILIA A. PCR Protocols. 1990 Jan 1; 288-299. Kogan KS, Gitschier GJ. .
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    174. Accurate prenatal diagnosis with novel polymerase chain reaction primers in a family with sporadic hemophilia A. Obstet Gynecol. 1989 Sep; 74(3 Pt 1):414-7. Sarkar G, Evans MI, Kogan S, Lusher J, Sommer SS. PMID: 2569705.
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    175. Functional dissection and sequence of yeast HAP1 activator. Cell. 1989 Jan 27; 56(2):291-301. Pfeifer K, Kim KS, Kogan S, Guarente L. PMID: 2643482.
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    176. Mutations of factor VIII cleavage sites in hemophilia A. Blood. 1988 Sep; 72(3):1022-8. Gitschier J, Kogan S, Levinson B, Tuddenham EG. PMID: 3137981.
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    177. Mutations of factor VIII cleavage sites in hemophilia A. Blood. 1988 Sep 1; 72(3):1022-1028. Gitschier GJ, Kogan KS, Levinson LB, Tuddenham TE. .
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    178. An Improved Method for Prenatal Diagnosis of Genetic Diseases by Analysis of Amplified DNA Sequences. Obstetrical & Gynecological Survey. 1988 Apr 1; 43(4):236-238. KOGAN KS, DOHERTY DM, GITSCHIER GJ. .
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    179. An Improved Method for Prenatal Diagnosis of Genetic Diseases by Analysis of Amplified DNA Sequences. Obstetrical & Gynecological Survey. 1988 Apr 1; 43(4):236-238. KOGAN KS, DOHERTY DM, GITSCHIER GJ. .
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    180. An improved method for prenatal diagnosis of genetic diseases by analysis of amplified DNA sequences. Application to hemophilia A. N Engl J Med. 1987 Oct 15; 317(16):985-90. Kogan SC, Doherty M, Gitschier J. PMID: 3657865.
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