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Ma Somsouk, MD, MAS

Title(s)Professor, Medicine
SchoolSchool of Medicine
Address1001 Potrero Ave
San Francisco CA 94110
Phone628-206-6480
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    Collapse Biography 
    Collapse Education and Training
    UCSF, Epidemiology and BiostatisticsM.A.S. 2008
    UCSF, Gastroenterology & HepatologyFellowship2008
    Harvard Medical SchoolM.D.2002
    UCLA-Harbor Medical CenterResidency2005
    Beijing Medical University, Research ScholarFellowship2001
    Pomona College, ChemistryB.A.1997
    Collapse Awards and Honors
    UCSF2016Dean M. Craig Endowed Chair in Gastrointestinal Medicine
    American Gastroenterology Association2015AGA Fellow
    UCSF Academic Senate Nomination2015Distinction in Mentoring
    Harvard2001Paul Dudley White / Andrew Sellard Fellowship
    Pomona College1997Magna Cum Laude

    Collapse Overview 
    Collapse Overview
    1. Leveraging digital health and care coordination to improve health services delivery to vulnerable populations. We embrace big data and technology to design, develop, and deliver economic and effective services for patients in the area of cancer screening and follow-up.

    2. Development of intestinal organoids from humans to understand barrier function, systemic inflammation, inflammatory bowel disease, HIV persistence, infection, and microbiome. Approaches employed: organoid models, isolation of epithelial cells, lymphocytes, microbiota, and interventional trials such as fecal transplant.

    Collapse Research 
    Collapse Research Activities and Funding
    Modeling intestinal dysfunction in HIV infection with organoid technology
    NIH/NIDDK R01DK123746Jan 10, 2020 - Dec 31, 2024
    Role: Co-Principal Investigator
    Delaney AIDS Research Enterprise to Cure HIV
    NIH/NIAID UM1AI126611Jul 14, 2016 - Jun 30, 2021
    Role: Co-Investigator
    Institute for HIV CURE Research
    amfAR 109301-59-RGRLJan 1, 2016 - Dec 31, 2020
    Role: Co-Investigator
    Intestinal MAIT Cells in HIV Infection
    NIH R01DK108350Sep 22, 2015 - Aug 31, 2020
    Role: Co-Investigator
    Investigating Mechanisms of HIV Persistence in the Gut
    NIH/NIDDK R01DK108349Sep 21, 2015 - Aug 31, 2020
    Role: Co-Investigator
    Fecal microbial transplantation to reduce HIV-associated inflammation
    NIH/NIDDK R21DK104664Aug 1, 2015 - Jul 31, 2017
    Role: Principal Investigator
    Timing of ART and homeostasis of the persistent HIV reservoir in the adult
    NIH/NIAID R01AI116368Feb 4, 2015 - Jan 31, 2020
    Role: Co-Investigator
    Understanding barriers to colorectal cancer screening in South Asians
    CDC U48DP004998-01S4Sep 1, 2014 - Mar 31, 2016
    Role: Principal Investigator
    Determinants of Functional Immune Defects in Treated HIV Infection and Aging
    NIH/NIAID R01AI110271Jun 1, 2014 - May 31, 2019
    Role: Co-Investigator
    HIV, Gut Mucosal Turnover and Inflammation, and the Risk of Colorectal Neoplasia
    NIH/NCI K23CA157929Sep 22, 2011 - Aug 31, 2016
    Role: Principal Investigator
    HIV-Specific T Cell Responses in Rectal Mucosa
    NIH R01AI057020Jul 11, 2003 - May 31, 2017
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Changes in gastrointestinal microbial communities influence HIV-specific CD8+ T-cell responsiveness to immune checkpoint blockade. AIDS. 2020 Aug 01; 34(10):1451-1460. SahBandar IN, Chew GM, Corley MJ, Pang APS, Tsai N, Hanks N, Khadka VS, Klatt NR, Hensley-McBain T, Somsouk M, Vujkovic-Cvijin I, Chow DC, Shikuma CM, Ndhlovu LC. PMID: 32675558.
      View in: PubMed   Mentions:    Fields:    
    2. Obesity and metabolic outcomes in a safety-net health system. Biodemography Soc Biol. 2020 Jul-Sep; 65(3):257-267. Huynh MP, Bradshaw PT, Tana MM, Rachocki C, Somsouk M. PMID: 32727275.
      View in: PubMed   Mentions:
    3. A Root Cause Analysis of Barriers to Timely Colonoscopy in California Safety-Net Health Systems. J Patient Saf. 2020 May 26. Sharma AE, Lyson HC, Cherian R, Somsouk M, Schillinger D, Sarkar U. PMID: 32467445.
      View in: PubMed   Mentions:    Fields:    
    4. Antiretroviral Therapy Concentrations Differ in Gut vs. Lymph Node Tissues and Are Associated With HIV Viral Transcription by a Novel RT-ddPCR Assay. J Acquir Immune Defic Syndr. 2020 Apr 15; 83(5):530-537. Lee SA, Telwatte S, Hatano H, Kashuba ADM, Cottrell ML, Hoh R, Liegler TJ, Stephenson S, Somsouk M, Hunt PW, Deeks SG, Yukl S, Savic RM. PMID: 32168200.
      View in: PubMed   Mentions: 1     Fields:    
    5. Standardized Workflows Improve Colonoscopy Follow-Up After Abnormal Fecal Immunochemical Tests in a Safety-Net System. Dig Dis Sci. 2020 Mar 31. Issaka RB, Rachocki C, Huynh MP, Chen E, Somsouk M. PMID: 32236885.
      View in: PubMed   Mentions: 1     Fields:    
    6. Effectiveness and Cost of Organized Outreach for Colorectal Cancer Screening: A Randomized, Controlled Trial. J Natl Cancer Inst. 2020 Mar 01; 112(3):305-313. Somsouk M, Rachocki C, Mannalithara A, Garcia D, Laleau V, Grimes B, Issaka RB, Chen E, Vittinghoff E, Shapiro JA, Ladabaum U. PMID: 31187126.
      View in: PubMed   Mentions:    Fields:    
    7. Human Immunodeficiency Virus (HIV)-Infected CCR6+ Rectal CD4+ T Cells and HIV Persistence On Antiretroviral Therapy. J Infect Dis. 2020 Feb 18; 221(5):744-755. Anderson JL, Khoury G, Fromentin R, Solomon A, Chomont N, Sinclair E, Milush JM, Hartogensis W, Bacchetti P, Roche M, Tumpach C, Gartner M, Pitman MC, Epling CL, Hoh R, Hecht FM, Somsouk M, Cameron PU, Deeks SG, Lewin SR. PMID: 31796951.
      View in: PubMed   Mentions: 2     Fields:    
    8. HIV-1-induced cytokines deplete homeostatic innate lymphoid cells and expand TCF7-dependent memory NK cells. Nat Immunol. 2020 03; 21(3):274-286. Wang Y, Lifshitz L, Gellatly K, Vinton CL, Busman-Sahay K, McCauley S, Vangala P, Kim K, Derr A, Jaiswal S, Kucukural A, McDonel P, Hunt PW, Greenough T, Houghton J, Somsouk M, Estes JD, Brenchley JM, Garber M, Deeks SG, Luban J. PMID: 32066947.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    9. Impact of Antiretroviral Therapy Duration on HIV-1 Infection of T Cells within Anatomic Sites. J Virol. 2020 Jan 17; 94(3). Lee E, von Stockenstrom S, Morcilla V, Odevall L, Hiener B, Shao W, Hartogensis W, Bacchetti P, Milush J, Liegler T, Sinclair E, Hatano H, Hoh R, Somsouk M, Hunt P, Boritz E, Douek D, Fromentin R, Chomont N, Deeks SG, Hecht FM, Palmer S. PMID: 31723024.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    10. Disparities in Hepatocellular Carcinoma Incidence in California: An Update. Cancer Epidemiol Biomarkers Prev. 2020 01; 29(1):79-87. Sangaramoorthy M, Yang J, DeRouen MC, Ho C, Somsouk M, Tana MM, Thompson CA, Gibbons J, Gomez SL, Shariff-Marco S. PMID: 31719066.
      View in: PubMed   Mentions:    Fields:    
    11. TFF3 interacts with LINGO2 to regulate EGFR activation for protection against colitis and gastrointestinal helminths. Nat Commun. 2019 09 27; 10(1):4408. Belle NM, Ji Y, Herbine K, Wei Y, Park J, Zullo K, Hung LY, Srivatsa S, Young T, Oniskey T, Pastore C, Nieves W, Somsouk M, Herbert DR. PMID: 31562318.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    12. Fecal Microbiota Transplantation in Pouchitis: Clinical, Endoscopic, Histologic, and Microbiota Results from a Pilot Study. Dig Dis Sci. 2020 Apr; 65(4):1099-1106. Selvig D, Piceno Y, Terdiman J, Zydek M, Umetsu SE, Balitzer D, Fadrosh D, Lynch K, Lamere B, Leith T, Kassam Z, Beck K, Lewin S, Ma A, Somsouk M, Lynch SV, El-Nachef N. PMID: 31302808.
      View in: PubMed   Mentions: 2     Fields:    
    13. HIV and the Gut Microbiota: Composition, Consequences, and Avenues for Amelioration. Curr HIV/AIDS Rep. 2019 06; 16(3):204-213. Vujkovic-Cvijin I, Somsouk M. PMID: 31037552.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    14. Serum Bovine Immunoglobulins Improve Inflammation and Gut Barrier Function in Persons with HIV and Enteropathy on Suppressive ART. Pathog Immun. 2019; 4(1):124-146. Utay NS, Somasunderam A, Hinkle JE, Petschow BW, Detzel CJ, Somsouk M, Fichtenbaum CJ, Weaver EM, Shaw AL, Asmuth DM. PMID: 31139758.
      View in: PubMed   Mentions:
    15. CD32-RNA Co-localizes with HIV-RNA in CD3+ Cells Found within Gut Tissues from Viremic and ART-Suppressed Individuals. Pathog Immun. 2019; 4(1):147-160. Vásquez JJ, Aguilar-Rodriguez BL, Rodriguez L, Hogan LE, Somsouk M, McCune JM, Deeks SG, Laszik ZG, Hunt PW, Henrich TJ. PMID: 31139759.
      View in: PubMed   Mentions:
    16. Fecal microbiota transplant for Crohn disease: A study evaluating safety, efficacy, and microbiome profile. United European Gastroenterol J. 2019 07; 7(6):807-814. Gutin L, Piceno Y, Fadrosh D, Lynch K, Zydek M, Kassam Z, LaMere B, Terdiman J, Ma A, Somsouk M, Lynch S, El-Nachef N. PMID: 31316785.
      View in: PubMed   Mentions:
    17. Increased mucosal neutrophil survival is associated with altered microbiota in HIV infection. PLoS Pathog. 2019 04; 15(4):e1007672. Hensley-McBain T, Wu MC, Manuzak JA, Cheu RK, Gustin A, Driscoll CB, Zevin AS, Miller CJ, Coronado E, Smith E, Chang J, Gale M, Somsouk M, Burgener AD, Hunt PW, Hope TJ, Collier AC, Klatt NR. PMID: 30973942.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    18. Cellular HIV Reservoirs and Viral Rebound from the Lymphoid Compartments of 4'-Ethynyl-2-Fluoro-2'-Deoxyadenosine (EFdA)-Suppressed Humanized Mice. Viruses. 2019 03 13; 11(3). Maidji E, Moreno ME, Rivera JM, Joshi P, Galkina SA, Kosikova G, Somsouk M, Stoddart CA. PMID: 30871222.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    19. Low Literacy Level Instructions and Reminder Calls Improve Patient Handling of Fecal Immunochemical Test Samples. Clin Gastroenterol Hepatol. 2019 08; 17(9):1822-1828. Wang A, Rachocki C, Shapiro JA, Issaka RB, Somsouk M. PMID: 30503967.
      View in: PubMed   Mentions: 1     Fields:    
    20. Gut and blood differ in constitutive blocks to HIV transcription, suggesting tissue-specific differences in the mechanisms that govern HIV latency. PLoS Pathog. 2018 11; 14(11):e1007357. Telwatte S, Lee S, Somsouk M, Hatano H, Baker C, Kaiser P, Kim P, Chen TH, Milush J, Hunt PW, Deeks SG, Wong JK, Yukl SA. PMID: 30440043.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    21. Population health interventions to improve colorectal cancer screening by fecal immunochemical tests: A systematic review. Prev Med. 2019 01; 118:113-121. Issaka RB, Avila P, Whitaker E, Bent S, Somsouk M. PMID: 30367972.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    22. Macrophage Activation Marker Soluble CD163 Is a Dynamic Marker of Liver Fibrogenesis in Human Immunodeficiency Virus/Hepatitis C Virus Coinfection. J Infect Dis. 2018 09 22; 218(9):1394-1403. Lidofsky A, Holmes JA, Feeney ER, Kruger AJ, Salloum S, Zheng H, Seguin IS, Altinbas A, Masia R, Corey KE, Gustafson JL, Schaefer EA, Hunt PW, Deeks S, Somsouk M, Chew KW, Chung RT, Alatrakchi N. PMID: 29868909.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    23. Colorectal Cancer Incidence Trends by Age, Stage, and Racial/Ethnic Group in California, 1990-2014. Cancer Epidemiol Biomarkers Prev. 2018 09; 27(9):1011-1018. Ellis L, Abrahão R, McKinley M, Yang J, Somsouk M, Marchand LL, Cheng I, Gomez SL, Shariff-Marco S. PMID: 30115679.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    24. Race/ethnicity is an independent risk factor for autoimmune hepatitis among the San Francisco underserved. Autoimmunity. 2018 08; 51(5):258-264. Lee B, Holt EW, Wong RJ, Sewell JL, Somsouk M, Khalili M, Maher JJ, Tana MM. PMID: 29890851.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    25. Yield of Colonoscopy After a Positive Result From a Fecal Immunochemical Test OC-Light. Clin Gastroenterol Hepatol. 2018 10; 16(10):1593-1597.e1. Alsayid M, Singh MH, Issaka R, Laleau V, Day L, Lee J, Allison J, Somsouk M. PMID: 29660528.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    26. A20 upregulation during treated HIV disease is associated with intestinal epithelial cell recovery and function. PLoS Pathog. 2018 03; 14(3):e1006806. Chitre AS, Kattah MG, Rosli YY, Pao M, Deswal M, Deeks SG, Hunt PW, Abdel-Mohsen M, Montaner LJ, Kim CC, Ma A, Somsouk M, McCune JM. PMID: 29505600.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    27. Increased HIV-1 transcriptional activity and infectious burden in peripheral blood and gut-associated CD4+ T cells expressing CD30. PLoS Pathog. 2018 02; 14(2):e1006856. Hogan LE, Vasquez J, Hobbs KS, Hanhauser E, Aguilar-Rodriguez B, Hussien R, Thanh C, Gibson EA, Carvidi AB, Smith LCB, Khan S, Trapecar M, Sanjabi S, Somsouk M, Stoddart CA, Kuritzkes DR, Deeks SG, Henrich TJ. PMID: 29470552.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    28. Hospitalizations for Autoimmune Hepatitis Disproportionately Affect Black and Latino Americans. Am J Gastroenterol. 2018 02; 113(2):243-253. Wen JW, Kohn MA, Wong R, Somsouk M, Khalili M, Maher J, Tana MM. PMID: 29380822.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    29. Differential Expression of CD8+ T Cell Cytotoxic Effector Molecules in Blood and Gastrointestinal Mucosa in HIV-1 Infection. J Immunol. 2018 03 01; 200(5):1876-1888. Kiniry BE, Hunt PW, Hecht FM, Somsouk M, Deeks SG, Shacklett BL. PMID: 29352005.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    30. Missed Opportunities in Colorectal Cancer Prevention in Patients With Inadequate Bowel Preparations. Clin Gastroenterol Hepatol. 2018 09; 16(9):1533-1534. Issaka RB, Singh MH, Rachocki C, Day LW, Horton C, Somsouk M. PMID: 29330098.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    31. The San Francisco Cancer Initiative: A Community Effort To Reduce The Population Burden Of Cancer. Health Aff (Millwood). 2018 01; 37(1):54-61. Hiatt RA, Sibley A, Fejerman L, Glantz S, Nguyen T, Pasick R, Palmer N, Perkins A, Potter MB, Somsouk M, Vargas RA, van 't Veer LJ, Ashworth A. PMID: 29309234.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    32. Colorectal Cancer Screening Among South Asians: Focus Group Findings on Attitudes, Knowledge, Barriers and Facilitators. J Health Care Poor Underserved. 2018; 29(4):1416-1437. Ivey SL, Mukherjea A, Patel A, Kapoor N, Rau S, Kazi E, Bhatia J, Somsouk M, Tseng W. PMID: 30449755.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    33. Risk factors for postpolypectomy bleeding in patients receiving anticoagulation or antiplatelet medications. Gastrointest Endosc. 2018 Apr; 87(4):1106-1113. Lin D, Soetikno RM, McQuaid K, Pham C, Doan G, Mou S, Shergill AK, Somsouk M, Rouse RV, Kaltenbach T. PMID: 29208464.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    34. Detection of HIV-1-specific gastrointestinal tissue resident CD8+ T-cells in chronic infection. Mucosal Immunol. 2018 05; 11(3):909-920. Kiniry BE, Li S, Ganesh A, Hunt PW, Somsouk M, Skinner PJ, Deeks SG, Shacklett BL. PMID: 29139476.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    35. Evaluation of oral serum-derived bovine immunoglobulins in HIV-infected patients with chronic idiopathic diarrhea. HIV Clin Trials. 2017 Nov-Dec; 18(5-6):205-213. Asmuth DM, Hinkle JE, LaMarca A, Fichtenbaum CJ, Somsouk M, Utay NS, Shaw AL, Petschow BW, Detzel CJ, Weaver EM. PMID: 29210625.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    36. An Optimized and Validated Method for Isolation and Characterization of Lymphocytes from HIV+ Human Gut Biopsies. AIDS Res Hum Retroviruses. 2017 Nov; 33(S1):S31-S39. Trapecar M, Khan S, Roan NR, Chen TH, Telwatte S, Deswal M, Pao M, Somsouk M, Deeks SG, Hunt PW, Yukl S, Sanjabi S. PMID: 28882052.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    37. A Randomized Controlled Trial of Lisinopril to Decrease Lymphoid Fibrosis in Antiretroviral-Treated, HIV-infected Individuals. Pathog Immun. 2017; 2(3):310-334. Cockerham LR, Yukl SA, Harvill K, Somsouk M, Joshi SK, Sinclair E, Liegler T, Hoh R, Lyons S, Hunt PW, Rupert A, Sereti I, Morcock DR, Rhodes A, Emson C, Hellerstein MK, Estes JD, Lewin S, Deeks SG, Hatano H. PMID: 28936485.
      View in: PubMed   Mentions:
    38. Circulating LOXL2 Levels Reflect Severity of Intestinal Fibrosis and GALT CD4+ T Lymphocyte Depletion in Treated HIV Infection. Pathog Immun. 2017; 2(2):239-252. Seang S, Somasunderam A, Nigalye M, Somsouk M, Schacker TW, Sanchez JL, Hunt PW, Utay NS, Lake JE. PMID: 28782046.
      View in: PubMed   Mentions:
    39. Limited engraftment of donor microbiome via one-time fecal microbial transplantation in treated HIV-infected individuals. Gut Microbes. 2017 09 03; 8(5):440-450. Vujkovic-Cvijin I, Rutishauser RL, Pao M, Hunt PW, Lynch SV, McCune JM, Somsouk M. PMID: 28541799.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    40. Human Immunodeficiency Virus Persistence and T-Cell Activation in Blood, Rectal, and Lymph Node Tissue in Human Immunodeficiency Virus-Infected Individuals Receiving Suppressive Antiretroviral Therapy. J Infect Dis. 2017 03 15; 215(6):911-919. Khoury G, Fromentin R, Solomon A, Hartogensis W, Killian M, Hoh R, Somsouk M, Hunt PW, Girling V, Sinclair E, Bacchetti P, Anderson JL, Hecht FM, Deeks SG, Cameron PU, Chomont N, Lewin SR. PMID: 28453847.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    41. Replication of CMV in the gut of HIV-infected individuals and epithelial barrier dysfunction. PLoS Pathog. 2017 02; 13(2):e1006202. Maidji E, Somsouk M, Rivera JM, Hunt PW, Stoddart CA. PMID: 28241080.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    42. Mucosal stromal fibroblasts markedly enhance HIV infection of CD4+ T cells. PLoS Pathog. 2017 02; 13(2):e1006163. Neidleman JA, Chen JC, Kohgadai N, Müller JA, Laustsen A, Thavachelvam K, Jang KS, Stürzel CM, Jones JJ, Ochsenbauer C, Chitre A, Somsouk M, Garcia MM, Smith JF, Greenblatt RM, Münch J, Jakobsen MR, Giudice LC, Greene WC, Roan NR. PMID: 28207890.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    43. Urgent colonoscopy in patients with lower GI bleeding: a systematic review and meta-analysis. Gastrointest Endosc. 2017 Jul; 86(1):107-117.e1. Kouanda AM, Somsouk M, Sewell JL, Day LW. PMID: 28174123.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansPHPublic Health
    44. Inadequate Utilization of Diagnostic Colonoscopy Following Abnormal FIT Results in an Integrated Safety-Net System. Am J Gastroenterol. 2017 02; 112(2):375-382. Issaka RB, Singh MH, Oshima SM, Laleau VJ, Rachocki CD, Chen EH, Day LW, Sarkar U, Somsouk M. PMID: 28154400.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    45. Predominance of weakly cytotoxic, T-betLowEomesNeg CD8+ T-cells in human gastrointestinal mucosa: implications for HIV infection. Mucosal Immunol. 2017 07; 10(4):1008-1020. Kiniry BE, Ganesh A, Critchfield JW, Hunt PW, Hecht FM, Somsouk M, Deeks SG, Shacklett BL. PMID: 27827375.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    46. Bacteroides are associated with GALT iNKT cell function and reduction of microbial translocation in HIV-1 infection. Mucosal Immunol. 2017 01; 10(1):69-78. Paquin-Proulx D, Ching C, Vujkovic-Cvijin I, Fadrosh D, Loh L, Huang Y, Somsouk M, Lynch SV, Hunt PW, Nixon DF, SenGupta D. PMID: 27049061.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    47. Protective association of colonoscopy against proximal and distal colon cancer and patterns in interval cancer. Gastrointest Endosc. 2015 Sep; 82(3):529-37.e1. Shergill AK, Conners EE, McQuaid KR, Epstein S, Ryan JC, Shah JN, Inadomi J, Somsouk M. PMID: 25936449.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    48. Longitudinal Genetic Characterization Reveals That Cell Proliferation Maintains a Persistent HIV Type 1 DNA Pool During Effective HIV Therapy. J Infect Dis. 2015 Aug 15; 212(4):596-607. von Stockenstrom S, Odevall L, Lee E, Sinclair E, Bacchetti P, Killian M, Epling L, Shao W, Hoh R, Ho T, Faria NR, Lemey P, Albert J, Hunt P, Loeb L, Pilcher C, Poole L, Hatano H, Somsouk M, Douek D, Boritz E, Deeks SG, Hecht FM, Palmer S. PMID: 25712966.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansCells
    49. Gut epithelial barrier and systemic inflammation during chronic HIV infection. AIDS. 2015 Jan 02; 29(1):43-51. Somsouk M, Estes JD, Deleage C, Dunham RM, Albright R, Inadomi JM, Martin JN, Deeks SG, McCune JM, Hunt PW. PMID: 25387317.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansCells
    50. The immunologic effects of mesalamine in treated HIV-infected individuals with incomplete CD4+ T cell recovery: a randomized crossover trial. PLoS One. 2014; 9(12):e116306. Somsouk M, Dunham RM, Cohen M, Albright R, Abdel-Mohsen M, Liegler T, Lifson J, Piatak M, Gorelick R, Huang Y, Wu Y, Hsue PY, Martin JN, Deeks SG, McCune JM, Hunt PW. PMID: 25545673.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    51. Lymphoid fibrosis occurs in long-term nonprogressors and persists with antiretroviral therapy but may be reversible with curative interventions. J Infect Dis. 2015 Apr 01; 211(7):1068-75. Sanchez JL, Hunt PW, Reilly CS, Hatano H, Beilman GJ, Khoruts A, Jasurda JS, Somsouk M, Thorkelson A, Russ S, Anderson J, Deeks SG, Schacker TW. PMID: 25344521.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    52. The CD8? memory stem T cell (T(SCM)) subset is associated with improved prognosis in chronic HIV-1 infection. J Virol. 2014 Dec; 88(23):13836-44. Ribeiro SP, Milush JM, Cunha-Neto E, Kallas EG, Kalil J, Somsouk M, Hunt PW, Deeks SG, Nixon DF, SenGupta D. PMID: 25253339.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    53. HIV-infected individuals with low CD4/CD8 ratio despite effective antiretroviral therapy exhibit altered T cell subsets, heightened CD8+ T cell activation, and increased risk of non-AIDS morbidity and mortality. PLoS Pathog. 2014 May; 10(5):e1004078. Serrano-Villar S, Sainz T, Lee SA, Hunt PW, Sinclair E, Shacklett BL, Ferre AL, Hayes TL, Somsouk M, Hsue PY, Van Natta ML, Meinert CL, Lederman MM, Hatano H, Jain V, Huang Y, Hecht FM, Martin JN, McCune JM, Moreno S, Deeks SG. PMID: 24831517.
      View in: PubMed   Mentions: 140     Fields:    Translation:HumansCells
    54. Esophageal varices on computed tomography and subsequent variceal hemorrhage. Abdom Imaging. 2014 Apr; 39(2):251-6. Somsouk M, To'o K, Ali M, Vittinghoff E, Yeh BM, Yee J, Monto A, Inadomi JM, Aslam R. PMID: 24366107.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    55. Challenges and possible solutions to colorectal cancer screening for the underserved. J Natl Cancer Inst. 2014 Apr; 106(4):dju032. Gupta S, Sussman DA, Doubeni CA, Anderson DS, Day L, Deshpande AR, Elmunzer BJ, Laiyemo AO, Mendez J, Somsouk M, Allison J, Bhuket T, Geng Z, Green BB, Itzkowitz SH, Martinez ME. PMID: 24681602.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansPHPublic Health
    56. Non-physician performance of lower and upper endoscopy: a systematic review and meta-analysis. Endoscopy. 2014 May; 46(5):401-10. Day LW, Siao D, Inadomi JM, Somsouk M. PMID: 24627086.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    57. Adverse events in older patients undergoing ERCP: a systematic review and meta-analysis. Endosc Int Open. 2014 Mar; 2(1):E28-36. Day LW, Lin L, Somsouk M. PMID: 26134610.
      View in: PubMed   Mentions:
    58. Discordance between peripheral and colonic markers of inflammation during suppressive ART. J Acquir Immune Defic Syndr. 2014 Feb 01; 65(2):133-41. Dunham RM, Vujkovic-Cvijin I, Yukl SA, Broadhurst MJ, Loke P, Albright RG, Wong JK, Lederman MM, Somsouk M, Hunt PW, Martin JN, Deeks SG, McCune JM. PMID: 24121758.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    59. A comparison of methods for measuring rectal HIV levels suggests that HIV DNA resides in cells other than CD4+ T cells, including myeloid cells. AIDS. 2014 Jan 28; 28(3):439-42. Yukl SA, Sinclair E, Somsouk M, Hunt PW, Epling L, Killian M, Girling V, Li P, Havlir DV, Deeks SG, Wong JK, Hatano H. PMID: 24322272.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    60. Commentary: Towards an effective and safe treatment of small intestine bacterial overgrowth - Authors' reply. Aliment Pharmacol Ther. 2013 Dec; 38(11-12):1411. Sewell JL, Somsouk M, Shah SC, Day LW. PMID: 24206377.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    61. The HIV-1 reservoir in eight patients on long-term suppressive antiretroviral therapy is stable with few genetic changes over time. Proc Natl Acad Sci U S A. 2013 Dec 17; 110(51):E4987-96. Josefsson L, von Stockenstrom S, Faria NR, Sinclair E, Bacchetti P, Killian M, Epling L, Tan A, Ho T, Lemey P, Shao W, Hunt PW, Somsouk M, Wylie W, Douek DC, Loeb L, Custer J, Hoh R, Poole L, Deeks SG, Hecht F, Palmer S. PMID: 24277811.
      View in: PubMed   Mentions: 116     Fields:    Translation:HumansCellsCTClinical Trials
    62. Prospective antiretroviral treatment of asymptomatic, HIV-1 infected controllers. PLoS Pathog. 2013; 9(10):e1003691. Hatano H, Yukl SA, Ferre AL, Graf EH, Somsouk M, Sinclair E, Abdel-Mohsen M, Liegler T, Harvill K, Hoh R, Palmer S, Bacchetti P, Hunt PW, Martin JN, McCune JM, Tracy RP, Busch MP, O'Doherty U, Shacklett BL, Wong JK, Deeks SG. PMID: 24130489.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCellsCTClinical Trials
    63. Helicobacter pylori: evidence-based review with a focus on immigrant populations. J Gen Intern Med. 2014 Mar; 29(3):520-8. Siao D, Somsouk M. PMID: 24065381.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCellsPHPublic Health
    64. Comparison of HIV DNA and RNA in gut-associated lymphoid tissue of HIV-infected controllers and noncontrollers. AIDS. 2013 Sep 10; 27(14):2255-60. Hatano H, Somsouk M, Sinclair E, Harvill K, Gilman L, Cohen M, Hoh R, Hunt PW, Martin JN, Wong JK, Deeks SG, Yukl SA. PMID: 24157906.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    65. Meta-analysis: antibiotic therapy for small intestinal bacterial overgrowth. Aliment Pharmacol Ther. 2013 Oct; 38(8):925-34. Shah SC, Day LW, Somsouk M, Sewell JL. PMID: 24004101.
      View in: PubMed   Mentions: 30     Fields:    Translation:Humans
    66. Dysbiosis of the gut microbiota is associated with HIV disease progression and tryptophan catabolism. Sci Transl Med. 2013 Jul 10; 5(193):193ra91. Vujkovic-Cvijin I, Dunham RM, Iwai S, Maher MC, Albright RG, Broadhurst MJ, Hernandez RD, Lederman MM, Huang Y, Somsouk M, Deeks SG, Hunt PW, Lynch SV, McCune JM. PMID: 23843452.
      View in: PubMed   Mentions: 188     Fields:    Translation:HumansAnimalsCells
    67. The immunologic effects of maraviroc intensification in treated HIV-infected individuals with incomplete CD4+ T-cell recovery: a randomized trial. Blood. 2013 Jun 06; 121(23):4635-46. Hunt PW, Shulman NS, Hayes TL, Dahl V, Somsouk M, Funderburg NT, McLaughlin B, Landay AL, Adeyemi O, Gilman LE, Clagett B, Rodriguez B, Martin JN, Schacker TW, Shacklett BL, Palmer S, Lederman MM, Deeks SG. PMID: 23589670.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansCells
    68. Late presentation of colorectal cancer in a vulnerable population. Am J Gastroenterol. 2013 Apr; 108(4):466-70. Ho C, Kornfield R, Vittinghoff E, Inadomi J, Yee H, Somsouk M. PMID: 23552303.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    69. Comparative analysis of measures of viral reservoirs in HIV-1 eradication studies. PLoS Pathog. 2013 Feb; 9(2):e1003174. Eriksson S, Graf EH, Dahl V, Strain MC, Yukl SA, Lysenko ES, Bosch RJ, Lai J, Chioma S, Emad F, Abdel-Mohsen M, Hoh R, Hecht F, Hunt P, Somsouk M, Wong J, Johnston R, Siliciano RF, Richman DD, O'Doherty U, Palmer S, Deeks SG, Siliciano JD. PMID: 23459007.
      View in: PubMed   Mentions: 246     Fields:    Translation:HumansCells
    70. Activation, exhaustion, and persistent decline of the antimicrobial MR1-restricted MAIT-cell population in chronic HIV-1 infection. Blood. 2013 Feb 14; 121(7):1124-35. Leeansyah E, Ganesh A, Quigley MF, Sönnerborg A, Andersson J, Hunt PW, Somsouk M, Deeks SG, Martin JN, Moll M, Shacklett BL, Sandberg JK. PMID: 23243281.
      View in: PubMed   Mentions: 108     Fields:    Translation:HumansCells
    71. Short communication: HIV+ viremic slow progressors maintain low regulatory T cell numbers in rectal mucosa but exhibit high T cell activation. AIDS Res Hum Retroviruses. 2013 Jan; 29(1):172-7. Shaw JM, Hunt PW, Critchfield JW, McConnell DH, Garcia JC, Pollard RB, Somsouk M, Deeks SG, Shacklett BL. PMID: 22998457.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    72. Adherence to colorectal cancer screening: a randomized clinical trial of competing strategies. Arch Intern Med. 2012 Apr 09; 172(7):575-82. Inadomi JM, Vijan S, Janz NK, Fagerlin A, Thomas JP, Lin YV, Muñoz R, Lau C, Somsouk M, El-Nachef N, Hayward RA. PMID: 22493463.
      View in: PubMed   Mentions: 138     Fields:    Translation:HumansPHPublic Health
    73. Adverse events in older patients undergoing colonoscopy: a systematic review and meta-analysis. Gastrointest Endosc. 2011 Oct; 74(4):885-96. Day LW, Kwon A, Inadomi JM, Walter LC, Somsouk M. PMID: 21951478.
      View in: PubMed   Mentions: 34     Fields:    Translation:Humans
    74. Prevalence of gastric cancer versus colorectal cancer in Asians with a positive fecal occult blood test. Indian J Gastroenterol. 2011 Sep; 30(5):209-16. Day LW, Cello JP, Somsouk M, Inadomi JM. PMID: 21948130.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    75. Increased frequency of regulatory T cells accompanies increased immune activation in rectal mucosae of HIV-positive noncontrollers. J Virol. 2011 Nov; 85(21):11422-34. Shaw JM, Hunt PW, Critchfield JW, McConnell DH, Garcia JC, Pollard RB, Somsouk M, Deeks SG, Shacklett BL. PMID: 21880771.
      View in: PubMed   Mentions: 49     Fields:    Translation:Cells
    76. Moderate ascites identifies patients with low model for end-stage liver disease scores awaiting liver transplantation who have a high mortality risk. Liver Transpl. 2011 Feb; 17(2):129-36. Somsouk M, Kornfield R, Vittinghoff E, Inadomi JM, Biggins SW. PMID: 21280185.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    77. Ascites improves upon [corrected] serum sodium plus [corrected] model for end-stage liver disease (MELD) for predicting mortality in patients with advanced liver disease. Aliment Pharmacol Ther. 2009 Oct; 30(7):741-8. Somsouk M, Guy J, Biggins SW, Vittinghoff E, Kohn MA, Inadomi JM. PMID: 19604177.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    78. New model for end stage liver disease improves prognostic capability after transjugular intrahepatic portosystemic shunt. Clin Gastroenterol Hepatol. 2009 Nov; 7(11):1236-40. Guy J, Somsouk M, Shiboski S, Kerlan R, Inadomi JM, Biggins SW. PMID: 19560557.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    79. Understanding liver health using the National Center for Health Statistics. Dig Dis Sci. 2009 Nov; 54(11):2325-9. Somsouk M, Yee HF, Biggins SW. PMID: 19424799.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    80. A cost-utility analysis of ablative therapy for Barrett's esophagus. Gastroenterology. 2009 Jun; 136(7):2101-2114.e1-6. Inadomi JM, Somsouk M, Madanick RD, Thomas JP, Shaheen NJ. PMID: 19272389.
      View in: PubMed   Mentions: 49     Fields:    Translation:Humans
    81. Management of obscure occult gastrointestinal bleeding: a cost-minimization analysis. Clin Gastroenterol Hepatol. 2008 Jun; 6(6):661-70. Somsouk M, Gralnek IM, Inadomi JM. PMID: 18550005.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    82. Actinomycosis mimicking a pancreatic head neoplasm diagnosed by EUS-guided FNA. Gastrointest Endosc. 2008 Jul; 68(1):186-7. Somsouk M, Shergill AK, Grenert JP, Harris H, Cello JP, Shah JN. PMID: 18291393.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    83. A cost-identification analysis of screening and surveillance of hepatitis C infection in a prospective cohort of dialysis patients. Dig Dis Sci. 2008 Apr; 53(4):1093-9. Somsouk M, Langfield DE, Inadomi JM, Yee HF. PMID: 17934829.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansPHPublic Health
    84. Will virtual colonoscopy replace optical colonoscopy for colorectal cancer screening? Gastroenterology. 2007 Oct; 133(4):1384-5; discussion 1385-6. Inadomi JM, Somsouk MA. PMID: 17919513.
      View in: PubMed   Mentions:    Fields:    
    85. Proton pump inhibitors and hip fracture: cause for alarm? Gastroenterology. 2007 May; 132(5):2063-5; discussion 2065. Inadomi JM, Somsouk MA. PMID: 17484900.
      View in: PubMed   Mentions:    Fields:    
    86. Determination of the three-dimensional, solution-phase structure of the macrolide antibiotic oxolide in CD2Cl2 and D2O from NMR constraints. Magn Reson Chem. 2005 Jan; 43(1):16-20. Steinmetz WE, Sparrow A, Somsouk M. PMID: 15468276.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    87. Constitutive activation of Stat3 signaling pathway in human colorectal carcinoma. World J Gastroenterol. 2004 Jun 01; 10(11):1569-73. Ma XT, Wang S, Ye YJ, Du RY, Cui ZR, Somsouk M. PMID: 15162527.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCells
    88. Hepatitis C virus is independently associated with increased insulin resistance after liver transplantation. Transplantation. 2004 Mar 15; 77(5):703-10. Delgado-Borrego A, Casson D, Schoenfeld D, Somsouk M, Terella A, Jordan SH, Bhan A, Baid S, Cosimi AB, Pascual M, Chung RT. PMID: 15021833.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    89. Critical elements of the immunoglobulin heavy chain gene enhancers for deregulated expression of bcl-2. Cancer Res. 2003 Oct 15; 63(20):6666-73. Heckman CA, Cao T, Somsouk L, Duan H, Mehew JW, Zhang CY, Boxer LM. PMID: 14583460.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    90. Spontaneous resolution of chronic hepatitis C virus disease after withdrawal of immunosuppression. Gastroenterology. 2003 Jun; 124(7):1946-9. Somsouk M, Lauer GM, Casson D, Terella A, Day CL, Walker BD, Chung RT. PMID: 12806627.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    91. Promoter structure and cell cycle dependent expression of the human methylpurine-DNA glycosylase gene. Mutat Res. 2000 Sep 15; 461(1):15-29. Bouziane M, Miao F, Bates SE, Somsouk L, Sang BC, Denissenko M, O'Connor TR. PMID: 10980409.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    92. Partial functional deficiency of E160D flap endonuclease-1 mutant in vitro and in vivo is due to defective cleavage of DNA substrates. J Biol Chem. 1998 Dec 04; 273(49):33064-72. Frank G, Qiu J, Somsouk M, Weng Y, Somsouk L, Nolan JP, Shen B. PMID: 9830061.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
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