Anatoly Urisman, MD, PhD
|School||UCSF School of Medicine|
|Address||513 Parnassus Avenue|
San Francisco CA 94117
|University of California, San Francisco||M.D.||2008|| Medicine|
|University of California, San Francisco||Ph.D.||2006|| Graduate Division (Biomedical Sciences)|
|University of California, Berkeley||BA||1999||Biochemistry|
2008-2010 Residency in Anatomic Pathology, UCSF
2010-2011 Pulmonary Pathology Fellowship, UCSF
2011-2014 Research Fellow, Department of Pathology, UCSF
2014-2016 Clinical Instructor, Department of Pathology, UCSF
2016-now Assistant Professor, Department of Pathology, UCSF
My research is focused on understanding regulation of cell signaling by post-tranlational modifications in cancer cells. Specifically, we are using targeted proteomic techniques to study phosphorylation dynamics in key signaling networks such as EGFR, RAS/ERK, and AKT/mTOR. The studies are aimed at identifying key regulatory phosphorylation sites relevant to tumor development, progression, response to targeted therapies, and development of resistance. As part of this effort, we are working on novel approaches for quantifying site-specific phosphorylation of low-abundance proteins, such as transcription factors and other nuclear targets of the intracellular signal transduction pathways.
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