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    Deepak Srivastava, MD

    SchoolUCSF School of Medicine
    Address1650 Owens St
    San Francisco CA 94107
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      Collapse Biography 
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      University of California, San FranciscoResidency School of Medicine

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      Our laboratory focuses on understanding the causes of heart disease and on using knowledge of cardiac developmental pathways to devise novel therapeutic approaches for human cardiac disorders. Specifically, we study the molecular events regulating early and late developmental decisions that instruct progenitor cells to adopt a cardiac cell fate and subsequently fashion a functioning heart. We focus on transcriptional and post-transcriptional steps, including those involving microRNAs. We have leveraged this knowledge to reprogram fibroblasts directly into cardiomyocyte-like cells for regenerative purposes. We also seek to identify the causes of human cardiovascular disease by applying modern genetic technologies for the study of complex traits such as congenital heart disease. By using a spectrum of approaches including mouse and human genetics, molecular and developmental biology, and biochemistry we hope to develop a broad understanding of the biology underlying cardiogenesis and cardiovascular disorders.

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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Kime C, Rand TA, Ivey KN, Srivastava D, Yamanaka S, Tomoda K. Practical Integration-Free Episomal Methods for Generating Human Induced Pluripotent Stem Cells. Curr Protoc Hum Genet. 2015; 87:21.2.1-21.2.21.
        View in: PubMed
      2. Ribeiro AJ, Ang YS, Fu JD, Rivas RN, Mohamed TM, Higgs GC, Srivastava D, Pruitt BL. Contractility of single cardiomyocytes differentiated from pluripotent stem cells depends on physiological shape and substrate stiffness. Proc Natl Acad Sci U S A. 2015 Oct 13; 112(41):12705-10.
        View in: PubMed
      3. Ivey KN, Srivastava D. microRNAs as Developmental Regulators. Cold Spring Harb Perspect Biol. 2015; 7(7).
        View in: PubMed
      4. White MP, Theodoris CV, Liu L, Collins WJ, Blue KW, Lee JH, Meng X, Robbins RC, Ivey KN, Srivastava D. NOTCH1 regulates matrix gla protein and calcification gene networks in human valve endothelium. J Mol Cell Cardiol. 2015 Jul; 84:13-23.
        View in: PubMed
      5. Rasmussen TL, Ma Y, Park CY, Harriss J, Pierce SA, Dekker JD, Valenzuela N, Srivastava D, Schwartz RJ, Stewart MD, Tucker HO. Smyd1 facilitates heart development by antagonizing oxidative and ER stress responses. PLoS One. 2015; 10(3):e0121765.
        View in: PubMed PMC4372598
      6. Theodoris CV, Li M, White MP, Liu L, He D, Pollard KS, Bruneau BG, Srivastava D. Human Disease Modeling Reveals Integrated Transcriptional and Epigenetic Mechanisms of NOTCH1 Haploinsufficiency. Cell. 2015 Mar 12; 160(6):1072-86.
        View in: PubMed
      7. Vedantham V, Galang G, Evangelista M, Deo RC, Srivastava D. RNA sequencing of mouse sinoatrial node reveals an upstream regulatory role for islet-1 in cardiac pacemaker cells. Circ Res. 2015 Feb 27; 116(5):797-803.
        View in: PubMed
      8. Fu JD, Srivastava D. Direct reprogramming of fibroblasts into cardiomyocytes for cardiac regenerative medicine. Circ J. 2015; 79(2):245-54.
        View in: PubMed
      9. Ang YS, Srivastava D. Oxygen: double-edged sword in cardiac function and repair. Circ Res. 2014 Oct 24; 115(10):824-5.
        View in: PubMed
      10. Funato N, Nakamura M, Richardson JA, Srivastava D, Yanagisawa H. Loss of Tbx1 induces bone phenotypes similar to cleidocranial dysplasia. Hum Mol Genet. 2015 Jan 15; 24(2):424-35.
        View in: PubMed
      11. Hua LL, Vedantham V, Barnes RM, Hu J, Robinson AS, Bressan M, Srivastava D, Black BL. Specification of the mouse cardiac conduction system in the absence of Endothelin signaling. Dev Biol. 2014 Sep 15; 393(2):245-54.
        View in: PubMed PMC4143461
      12. Hu H, Roach JC, Coon H, Guthery SL, Voelkerding KV, Margraf RL, Durtschi JD, Tavtigian SV. A unified test of linkage analysis and rare-variant association for analysis of pedigree sequence data. Nat Biotechnol. 2014 Jul; 32(7):663-9.
        View in: PubMed PMC4157619
      13. King IN, Yartseva V, Salas D, Kumar A, Heidersbach A, Ando DM, Stallings NR, Elliott JL, Srivastava D, Ivey KN. The RNA-binding protein TDP-43 selectively disrupts microRNA-1/206 incorporation into the RNA-induced silencing complex. J Biol Chem. 2014 May 16; 289(20):14263-71.
        View in: PubMed PMC4022891
      14. Wang H, Cao N, Spencer CI, Nie B, Ma T, Xu T, Zhang Y, Wang X, Srivastava D, Ding S. Small molecules enable cardiac reprogramming of mouse fibroblasts with a single factor, Oct4. Cell Rep. 2014 Mar 13; 6(5):951-60.
        View in: PubMed PMC4004339
      15. Bruneau BG, Srivastava D. Congenital heart disease: entering a new era of human genetics. Circ Res. 2014 Feb 14; 114(4):598-9.
        View in: PubMed
      16. Heidersbach A, Saxby C, Carver-Moore K, Huang Y, Ang YS, de Jong PJ, Ivey KN, Srivastava D. microRNA-1 regulates sarcomere formation and suppresses smooth muscle gene expression in the mammalian heart. Elife. 2013; 2:e01323.
        View in: PubMed PMC3833424
      17. Worringer KA, Rand TA, Hayashi Y, Sami S, Takahashi K, Tanabe K, Narita M, Srivastava D, Yamanaka S. The let-7/LIN-41 pathway regulates reprogramming to human induced pluripotent stem cells by controlling expression of prodifferentiation genes. Cell Stem Cell. 2014 Jan 2; 14(1):40-52.
        View in: PubMed PMC3982312
      18. Qian L, Srivastava D. Direct cardiac reprogramming: from developmental biology to cardiac regeneration. Circ Res. 2013 Sep 13; 113(7):915-21.
        View in: PubMed PMC3869462
      19. Srivastava D, Berry EC. Cardiac reprogramming: from mouse toward man. Curr Opin Genet Dev. 2013 Oct; 23(5):574-8.
        View in: PubMed PMC3782415
      20. Fu JD, Stone NR, Liu L, Spencer CI, Qian L, Hayashi Y, Delgado-Olguin P, Ding S, Bruneau BG, Srivastava D. Direct reprogramming of human fibroblasts toward a cardiomyocyte-like state. Stem Cell Reports. 2013; 1(3):235-47.
        View in: PubMed PMC3849259
      21. Cheng P, Andersen P, Hassel D, Kaynak BL, Limphong P, Juergensen L, Kwon C, Srivastava D. Fibronectin mediates mesendodermal cell fate decisions. Development. 2013 Jun; 140(12):2587-96.
        View in: PubMed PMC3666385
      22. Qian L, Berry EC, Fu JD, Ieda M, Srivastava D. Reprogramming of mouse fibroblasts into cardiomyocyte-like cells in vitro. Nat Protoc. 2013 Jun; 8(6):1204-15.
        View in: PubMed
      23. Srivastava D, Heidersbach AJ. Small solutions to big problems: microRNAs for cardiac regeneration. Circ Res. 2013 May 24; 112(11):1412-4.
        View in: PubMed PMC3760376
      24. Spindler MJ, Burmeister BT, Huang Y, Hsiao EC, Salomonis N, Scott MJ, Srivastava D, Carnegie GK, Conklin BR. AKAP13 Rho-GEF and PKD-binding domain deficient mice develop normally but have an abnormal response to ß-adrenergic-induced cardiac hypertrophy. PLoS One. 2013; 8(4):e62705.
        View in: PubMed PMC3637253
      25. Srivastava D, Cordes Metzler KR. Fending for a Braveheart. EMBO J. 2013 May 2; 32(9):1211-3.
        View in: PubMed PMC3642680
      26. Limphong P, Zhang H, Christians E, Liu Q, Riedel M, Ivey K, Cheng P, Mitzelfelt K, Taylor G, Winge D, Srivastava D, Benjamin I. Modeling human protein aggregation cardiomyopathy using murine induced pluripotent stem cells. Stem Cells Transl Med. 2013 Mar; 2(3):161-6.
        View in: PubMed PMC3659767
      27. White MP, Rufaihah AJ, Liu L, Ghebremariam YT, Ivey KN, Cooke JP, Srivastava D. Limited gene expression variation in human embryonic stem cell and induced pluripotent stem cell-derived endothelial cells. Stem Cells. 2013 Jan; 31(1):92-103.
        View in: PubMed PMC3528812
      28. Ivey KN Srivastava D. Tam PPL, Nelson WJ, Rossant J, Eds. Mammalian Development: Networks, Switches, and Morphogenetic Processes. MicroRNAs as developmental regulators. 2013; 33–42.
      29. Plath K, Srivastava D, Alvarez-Buylla A, Tanaka EM, Kriegstein AR. Stem cells in the land of the rising sun: ISSCR 2012. Cell Stem Cell. 2012 Nov 2; 11(5):607-14.
        View in: PubMed
      30. Vedantham V, Evangelista M, Huang Y, Srivastava D. Spatiotemporal regulation of an Hcn4 enhancer defines a role for Mef2c and HDACs in cardiac electrical patterning. Dev Biol. 2013 Jan 1; 373(1):149-62.
        View in: PubMed PMC3510001
      31. Farina NH, Hausburg M, Betta ND, Pulliam C, Srivastava D, Cornelison D, Olwin BB. A role for RNA post-transcriptional regulation in satellite cell activation. Skelet Muscle. 2012; 2(1):21.
        View in: PubMed PMC3563611
      32. Srivastava D, Ieda M, Fu J, Qian L. Cardiac repair with thymosin ß4 and cardiac reprogramming factors. Ann N Y Acad Sci. 2012 Oct; 1270:66-72.
        View in: PubMed
      33. Wamstad JA, Alexander JM, Truty RM, Shrikumar A, Li F, Eilertson KE, Ding H, Wylie JN, Pico AR, Capra JA, Erwin G, Kattman SJ, Keller GM, Srivastava D, Levine SS, Pollard KS, Holloway AK, Boyer LA, Bruneau BG. Dynamic and coordinated epigenetic regulation of developmental transitions in the cardiac lineage. Cell. 2012 Sep 28; 151(1):206-20.
        View in: PubMed PMC3462286
      34. Hassel D, Cheng P, White MP, Ivey KN, Kroll J, Augustin HG, Katus HA, Stainier DY, Srivastava D. MicroRNA-10 regulates the angiogenic behavior of zebrafish and human endothelial cells by promoting vascular endothelial growth factor signaling. Circ Res. 2012 Nov 9; 111(11):1421-33.
        View in: PubMed PMC3525481
      35. Tomoda K, Takahashi K, Leung K, Okada A, Narita M, Yamada NA, Eilertson KE, Tsang P, Baba S, White MP, Sami S, Srivastava D, Conklin BR, Panning B, Yamanaka S. Derivation conditions impact X-inactivation status in female human induced pluripotent stem cells. Cell Stem Cell. 2012 Jul 6; 11(1):91-9.
        View in: PubMed PMC3396435
      36. Srivastava DP, Woolfrey KM, Jones KA, Anderson CT, Smith KR, Russell TA, Lee H, Yasvoina MV, Wokosin DL, Ozdinler PH, Shepherd GM, Penzes P. An autism-associated variant of Epac2 reveals a role for Ras/Epac2 signaling in controlling basal dendrite maintenance in mice. PLoS Biol. 2012; 10(6):e1001350.
        View in: PubMed PMC3383751
      37. Srivastava D, Ieda M. Critical factors for cardiac reprogramming. Circ Res. 2012 Jun 22; 111(1):5-8.
        View in: PubMed PMC3404813
      38. Qian L, Huang Y, Spencer CI, Foley A, Vedantham V, Liu L, Conway SJ, Fu JD, Srivastava D. In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes. Nature. 2012 May 31; 485(7400):593-8.
        View in: PubMed PMC3369107
      39. Misra C, Sachan N, McNally CR, Koenig SN, Nichols HA, Guggilam A, Lucchesi PA, Pu WT, Srivastava D, Garg V. Congenital heart disease-causing Gata4 mutation displays functional deficits in vivo. PLoS Genet. 2012; 8(5):e1002690.
        View in: PubMed PMC3349729
      40. Park CY, Jeker LT, Carver-Moore K, Oh A, Liu HJ, Cameron R, Richards H, Li Z, Adler D, Yoshinaga Y, Martinez M, Nefadov M, Abbas AK, Weiss A, Lanier LL, de Jong PJ, Bluestone JA, Srivastava D, McManus MT. A resource for the conditional ablation of microRNAs in the mouse. Cell Rep. 2012 Apr 19; 1(4):385-91.
        View in: PubMed
      41. Kathiresan S, Srivastava D. Genetics of human cardiovascular disease. Cell. 2012 Mar 16; 148(6):1242-57.
        View in: PubMed PMC3319439
      42. Funato N, Nakamura M, Richardson JA, Srivastava D, Yanagisawa H. Tbx1 regulates oral epithelial adhesion and palatal development. Hum Mol Genet. 2012 Jun 1; 21(11):2524-37.
        View in: PubMed PMC3607464
      43. Bernstein HS, Srivastava D. Stem cell therapy for cardiac disease. Pediatr Res. 2012 Apr; 71(4 Pt 2):491-9.
        View in: PubMed
      44. Baldwin HS Srivastava D. Allen HD, Driscoll DJ, Shaddy RE, Feltes TF, Eds. Moss and Adams' Heart Disease in Infants, Children and Adolescents. Molecular determinants of cardiac development and disease. 2012.
      45. Roach JC, Glusman G, Hubley R, Montsaroff SZ, Holloway AK, Mauldin DE, Srivastava D, Garg V, Pollard KS, Galas DJ, Hood L, Smit AF. Chromosomal haplotypes by genetic phasing of human families. Am J Hum Genet. 2011 Sep 9; 89(3):382-97.
        View in: PubMed PMC3169815
      46. Kwon C, Cheng P, King IN, Andersen P, Shenje L, Nigam V, Srivastava D. Notch post-translationally regulates ß-catenin protein in stem and progenitor cells. Nat Cell Biol. 2011 Oct; 13(10):1244-51.
        View in: PubMed PMC3187850
      47. AlRais F, Feldstein VA, Srivastava D, Gosnell K, Moon-Grady AJ. Monochorionic twins discordant for congenital heart disease: a referral center's experience and possible pathophysiologic mechanisms. Prenat Diagn. 2011 Oct; 31(10):978-84.
        View in: PubMed
      48. Qian L, Wythe JD, Liu J, Cartry J, Vogler G, Mohapatra B, Otway RT, Huang Y, King IN, Maillet M, Zheng Y, Crawley T, Taghli-Lamallem O, Semsarian C, Dunwoodie S, Winlaw D, Harvey RP, Fatkin D, Towbin JA, Molkentin JD, Srivastava D, Ocorr K, Bruneau BG, Bodmer R. Tinman/Nkx2-5 acts via miR-1 and upstream of Cdc42 to regulate heart function across species. J Cell Biol. 2011 Jun 27; 193(7):1181-96.
        View in: PubMed PMC3216339
      49. Shieh JT, Huang Y, Gilmore J, Srivastava D. Elevated miR-499 levels blunt the cardiac stress response. PLoS One. 2011; 6(5):e19481.
        View in: PubMed PMC3090396
      50. King IN, Qian L, Liang J, Huang Y, Shieh JT, Kwon C, Srivastava D. A genome-wide screen reveals a role for microRNA-1 in modulating cardiac cell polarity. Dev Cell. 2011 Apr 19; 20(4):497-510.
        View in: PubMed PMC3086096
      51. Fish JE, Wythe JD, Xiao T, Bruneau BG, Stainier DY, Srivastava D, Woo S. A Slit/miR-218/Robo regulatory loop is required during heart tube formation in zebrafish. Development. 2011 Apr; 138(7):1409-19.
        View in: PubMed PMC3050667
      52. Qian L, Van Laake LW, Huang Y, Liu S, Wendland MF, Srivastava D. miR-24 inhibits apoptosis and represses Bim in mouse cardiomyocytes. J Exp Med. 2011 Mar 14; 208(3):549-60.
        View in: PubMed PMC3058576
      53. Li Q, Kannan A, DeMayo FJ, Lydon JP, Cooke PS, Yamagishi H, Srivastava D, Bagchi MK, Bagchi IC. The antiproliferative action of progesterone in uterine epithelium is mediated by Hand2. Science. 2011 Feb 18; 331(6019):912-6.
        View in: PubMed PMC3320855
      54. Yu S, Crawford D, Tsuchihashi T, Behrens TW, Srivastava D. The chemokine receptor CXCR7 functions to regulate cardiac valve remodeling. Dev Dyn. 2011 Feb; 240(2):384-93.
        View in: PubMed PMC3079332
      55. Srivastava D. Rudplph's Pediatrics (Rudolph C, Rudolph A, Lister G, First L, Gershon A, Eds). Control of embryologic cardiac development. 2011.
      56. Tsuchihashi T, Maeda J, Shin CH, Ivey KN, Black BL, Olson EN, Yamagishi H, Srivastava D. Hand2 function in second heart field progenitors is essential for cardiogenesis. Dev Biol. 2011 Mar 1; 351(1):62-9.
        View in: PubMed PMC3039109
      57. Sheehy NT, Cordes KR, White MP, Ivey KN, Srivastava D. The neural crest-enriched microRNA miR-452 regulates epithelial-mesenchymal signaling in the first pharyngeal arch. Development. 2010 Dec; 137(24):4307-16.
        View in: PubMed PMC2990216
      58. Park CY, Pierce SA, von Drehle M, Ivey KN, Morgan JA, Blau HM, Srivastava D. skNAC, a Smyd1-interacting transcription factor, is involved in cardiac development and skeletal muscle growth and regeneration. Proc Natl Acad Sci U S A. 2010 Nov 30; 107(48):20750-5.
        View in: PubMed PMC2996447
      59. Maitra M, Koenig SN, Srivastava D, Garg V. Identification of GATA6 sequence variants in patients with congenital heart defects. Pediatr Res. 2010 Oct; 68(4):281-5.
        View in: PubMed PMC2940936
      60. Ieda M, Fu JD, Delgado-Olguin P, Vedantham V, Hayashi Y, Bruneau BG, Srivastava D. Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors. Cell. 2010 Aug 6; 142(3):375-86.
        View in: PubMed PMC2919844
      61. Ivey KN, Srivastava D. MicroRNAs as regulators of differentiation and cell fate decisions. Cell Stem Cell. 2010 Jul 2; 7(1):36-41.
        View in: PubMed
      62. Nigam V, Sievers HH, Jensen BC, Sier HA, Simpson PC, Srivastava D, Mohamed SA. Altered microRNAs in bicuspid aortic valve: a comparison between stenotic and insufficient valves. J Heart Valve Dis. 2010 Jul; 19(4):459-65.
        View in: PubMed
      63. van Laake LW, Qian L, Cheng P, Huang Y, Hsiao EC, Conklin BR, Srivastava D. Reporter-based isolation of induced pluripotent stem cell- and embryonic stem cell-derived cardiac progenitors reveals limited gene expression variance. Circ Res. 2010 Aug 6; 107(3):340-7.
        View in: PubMed PMC2919280
      64. Shrivastava S, Srivastava D, Olson EN, DiMaio JM, Bock-Marquette I. Thymosin beta4 and cardiac repair. Ann N Y Acad Sci. 2010 Apr; 1194:87-96.
        View in: PubMed
      65. Qian L, Srivastava D. Monkeying around with cardiac progenitors: hope for the future. J Clin Invest. 2010 Apr; 120(4):1034-6.
        View in: PubMed PMC2846073
      66. Cordes KR, Srivastava D, Ivey KN. MicroRNAs in cardiac development. Pediatr Cardiol. 2010 Apr; 31(3):349-56.
        View in: PubMed PMC2836460
      67. Hayashi-Takagi A, Takaki M, Graziane N, Seshadri S, Murdoch H, Dunlop AJ, Makino Y, Seshadri AJ, Ishizuka K, Srivastava DP, Xie Z, Baraban JM, Houslay MD, Tomoda T, Brandon NJ, Kamiya A, Yan Z, Penzes P, Sawa A. Disrupted-in-Schizophrenia 1 (DISC1) regulates spines of the glutamate synapse via Rac1. Nat Neurosci. 2010 Mar; 13(3):327-32.
        View in: PubMed PMC2846623
      68. Bruneau BG, Burn J, Srivastava D. Paediatric Cardiology (Anderson RH, Baker EJ, Penny D, Redington AN, Rigby ML, Wernovsky G, Eds). The Aetiology of Congenital Cardiac Disease. 2010; 161–171.
      69. Cordes KR, Srivastava D. Heart Development and Regeneration (Rosenthal N, Harvey R, Eds). MicroRNA regulation of cardiac development and disease. 2010; 2:729–740.
      70. Fish JE, Yan MS, Matouk CC, St Bernard R, Ho JJ, Ho JJ, Gavryushova A, Srivastava D, Marsden PA. Hypoxic repression of endothelial nitric-oxide synthase transcription is coupled with eviction of promoter histones. J Biol Chem. 2010 Jan 8; 285(2):810-26.
        View in: PubMed PMC2801283
      71. Lisé MF, Srivastava DP, Arstikaitis P, Lett RL, Sheta R, Viswanathan V, Penzes P, O'Connor TP, El-Husseini A. Myosin-Va-interacting protein, RILPL2, controls cell shape and neuronal morphogenesis via Rac signaling. J Cell Sci. 2009 Oct 15; 122(Pt 20):3810-21.
        View in: PubMed PMC2758809
      72. Nigam V, Srivastava D. Notch1 represses osteogenic pathways in aortic valve cells. J Mol Cell Cardiol. 2009 Dec; 47(6):828-34.
        View in: PubMed PMC2783189
      73. Kwon C, Qian L, Cheng P, Nigam V, Arnold J, Srivastava D. A regulatory pathway involving Notch1/beta-catenin/Isl1 determines cardiac progenitor cell fate. Nat Cell Biol. 2009 Aug; 11(8):951-7.
        View in: PubMed PMC2748816
      74. Shieh JT, Srivastava D. Heart malformation: what are the chances it could happen again? Circulation. 2009 Jul 28; 120(4):269-71.
        View in: PubMed PMC2836435
      75. Cordes KR, Sheehy NT, White MP, Berry EC, Morton SU, Muth AN, Lee TH, Miano JM, Ivey KN, Srivastava D. miR-145 and miR-143 regulate smooth muscle cell fate and plasticity. Nature. 2009 Aug 6; 460(7256):705-10.
        View in: PubMed PMC2769203
      76. Bock-Marquette I, Shrivastava S, Pipes GC, Thatcher JE, Blystone A, Shelton JM, Galindo CL, Melegh B, Srivastava D, Olson EN, DiMaio JM. Thymosin beta4 mediated PKC activation is essential to initiate the embryonic coronary developmental program and epicardial progenitor cell activation in adult mice in vivo. J Mol Cell Cardiol. 2009 May; 46(5):728-38.
        View in: PubMed PMC2768533
      77. Cordes KR, Srivastava D. MicroRNA regulation of cardiovascular development. Circ Res. 2009 Mar 27; 104(6):724-32.
        View in: PubMed PMC2664538
      78. Ellis J, Bruneau BG, Keller G, Lemischka IR, Nagy A, Rossant J, Srivastava D, Zandstra PW, Stanford WL. Alternative induced pluripotent stem cell characterization criteria for in vitro applications. Cell Stem Cell. 2009 Mar 6; 4(3):198-9; author reply 202.
        View in: PubMed
      79. Ieda M, Tsuchihashi T, Ivey KN, Ross RS, Hong TT, Shaw RM, Srivastava D. Cardiac fibroblasts regulate myocardial proliferation through beta1 integrin signaling. Dev Cell. 2009 Feb; 16(2):233-44.
        View in: PubMed PMC2664087
      80. Fish JE, Srivastava D. MicroRNAs: opening a new vein in angiogenesis research. Sci Signal. 2009 Jan 6; 2(52):pe1.
        View in: PubMed PMC2680274
      81. Srivastava D, Kwon C. Handbook of Cell Signaling (Bradshaw RA, Dennis EA, Eds). Signaling pathways involved in cardiogenesis. 2009; 3:2601–2609.
      82. Kwon C, Cordes KR, Srivastava D. Wnt/beta-catenin signaling acts at multiple developmental stages to promote mammalian cardiogenesis. Cell Cycle. 2008 Dec 15; 7(24):3815-8.
        View in: PubMed PMC2727475
      83. Maitra M, Schluterman MK, Nichols HA, Richardson JA, Lo CW, Srivastava D, Garg V. Interaction of Gata4 and Gata6 with Tbx5 is critical for normal cardiac development. Dev Biol. 2009 Feb 15; 326(2):368-77.
        View in: PubMed PMC2651674
      84. Niu Z, Iyer D, Conway SJ, Martin JF, Ivey K, Srivastava D, Nordheim A, Schwartz RJ. Serum response factor orchestrates nascent sarcomerogenesis and silences the biomineralization gene program in the heart. Proc Natl Acad Sci U S A. 2008 Nov 18; 105(46):17824-9.
        View in: PubMed PMC2584699
      85. Morton SU, Scherz PJ, Cordes KR, Ivey KN, Stainier DY, Srivastava D. microRNA-138 modulates cardiac patterning during embryonic development. Proc Natl Acad Sci U S A. 2008 Nov 18; 105(46):17830-5.
        View in: PubMed
      86. Ransom JF, King IN, Garg V, Srivastava D. A rare human sequence variant reveals myocardin autoinhibition. J Biol Chem. 2008 Dec 19; 283(51):35845-52.
        View in: PubMed PMC2602885
      87. Fish JE, Santoro MM, Morton SU, Yu S, Yeh RF, Wythe JD, Ivey KN, Bruneau BG, Stainier DY, Srivastava D. miR-126 regulates angiogenic signaling and vascular integrity. Dev Cell. 2008 Aug; 15(2):272-84.
        View in: PubMed PMC2604134
      88. Ivey KN, Sutcliffe D, Richardson J, Clyman RI, Garcia JA, Srivastava D. Transcriptional regulation during development of the ductus arteriosus. Circ Res. 2008 Aug 15; 103(4):388-95.
        View in: PubMed PMC2645272
      89. Saxena A, Fish JE, White MD, Yu S, Smyth JW, Shaw RM, DiMaio JM, Srivastava D. Stromal cell-derived factor-1alpha is cardioprotective after myocardial infarction. Circulation. 2008 Apr 29; 117(17):2224-31.
        View in: PubMed PMC2743260
      90. Ivey KN, Muth A, Arnold J, King FW, Yeh RF, Fish JE, Hsiao EC, Schwartz RJ, Conklin BR, Bernstein HS, Srivastava D. MicroRNA regulation of cell lineages in mouse and human embryonic stem cells. Cell Stem Cell. 2008 Mar 6; 2(3):219-29.
        View in: PubMed PMC2293325
      91. Nigam V, Srivastava D. Inborn Errors of Development (Epstein CJ, Ed). Molecular regulation of cardiogenesis. 2008; 124–129.
      92. Schrick C, Fischer A, Srivastava DP, Tronson NC, Penzes P, Radulovic J. N-cadherin regulates cytoskeletally associated IQGAP1/ERK signaling and memory formation. Neuron. 2007 Sep 6; 55(5):786-98.
        View in: PubMed PMC2064867
      93. Jia H, King IN, Chopra SS, Wan H, Ni TT, Jiang C, Guan X, Wells S, Srivastava D, Zhong TP. Vertebrate heart growth is regulated by functional antagonism between Gridlock and Gata5. Proc Natl Acad Sci U S A. 2007 Aug 28; 104(35):14008-13.
        View in: PubMed PMC1955785
      94. Srivastava D, Saxena A, Michael Dimaio J, Bock-Marquette I. Thymosin beta4 is cardioprotective after myocardial infarction. Ann N Y Acad Sci. 2007 Sep; 1112:161-70.
        View in: PubMed
      95. Rajagopal SK, Ma Q, Obler D, Shen J, Manichaikul A, Tomita-Mitchell A, Boardman K, Briggs C, Garg V, Srivastava D, Goldmuntz E, Broman KW, Benson DW, Smoot LB, Pu WT. Spectrum of heart disease associated with murine and human GATA4 mutation. J Mol Cell Cardiol. 2007 Dec; 43(6):677-85.
        View in: PubMed PMC2573470
      96. Kwon C, Arnold J, Hsiao EC, Taketo MM, Conklin BR, Srivastava D. Canonical Wnt signaling is a positive regulator of mammalian cardiac progenitors. Proc Natl Acad Sci U S A. 2007 Jun 26; 104(26):10894-9.
        View in: PubMed PMC1904134
      97. Pierpont ME, Basson CT, Benson DW, Gelb BD, Giglia TM, Goldmuntz E, McGee G, Sable CA, Srivastava D, Webb CL. Genetic basis for congenital heart defects: current knowledge: a scientific statement from the American Heart Association Congenital Cardiac Defects Committee, Council on Cardiovascular Disease in the Young: endorsed by the American Academy of Pediatrics. Circulation. 2007 Jun 12; 115(23):3015-38.
        View in: PubMed
      98. Xin M, Small EM, van Rooij E, Qi X, Richardson JA, Srivastava D, Nakagawa O, Olson EN. Essential roles of the bHLH transcription factor Hrt2 in repression of atrial gene expression and maintenance of postnatal cardiac function. Proc Natl Acad Sci U S A. 2007 May 8; 104(19):7975-80.
        View in: PubMed PMC1876557
      99. Schluterman MK, Krysiak AE, Kathiriya IS, Abate N, Chandalia M, Srivastava D, Garg V. Screening and biochemical analysis of GATA4 sequence variations identified in patients with congenital heart disease. Am J Med Genet A. 2007 Apr 15; 143A(8):817-23.
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      100. Zhao Y, Ransom JF, Li A, Vedantham V, von Drehle M, Muth AN, Tsuchihashi T, McManus MT, Schwartz RJ, Srivastava D. Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2. Cell. 2007 Apr 20; 129(2):303-17.
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      101. Zhao Y, Srivastava D. A developmental view of microRNA function. Trends Biochem Sci. 2007 Apr; 32(4):189-97.
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      102. Samal E, Srivastava D. Advances in Developmental Biology (Bodmer R, Ed). Role of microRNAs in Cardiovascular Biology. 2007; 18:167–178.
      103. Ransom J, Srivastava D. The genetics of cardiac birth defects. Semin Cell Dev Biol. 2007 Feb; 18(1):132-9.
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      104. Ivey KN, Srivastava D. The paradoxical patent ductus arteriosus. J Clin Invest. 2006 Nov; 116(11):2863-5.
        View in: PubMed PMC1626120
      105. Ramana KV, Willis MS, White MD, Horton JW, DiMaio JM, Srivastava D, Bhatnagar A, Srivastava SK. Endotoxin-induced cardiomyopathy and systemic inflammation in mice is prevented by aldose reductase inhibition. Circulation. 2006 Oct 24; 114(17):1838-46.
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      106. Srivastava D. Making or breaking the heart: from lineage determination to morphogenesis. Cell. 2006 Sep 22; 126(6):1037-48.
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      107. Srivastava D, Yu S. Stretching to meet needs: integrin-linked kinase and the cardiac pump. Genes Dev. 2006 Sep 1; 20(17):2327-31.
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      108. Srivastava D, Ivey KN. Potential of stem-cell-based therapies for heart disease. Nature. 2006 Jun 29; 441(7097):1097-9.
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      109. Capellini TD, Di Giacomo G, Salsi V, Brendolan A, Ferretti E, Srivastava D, Zappavigna V, Selleri L. Pbx1/Pbx2 requirement for distal limb patterning is mediated by the hierarchical control of Hox gene spatial distribution and Shh expression. Development. 2006 Jun; 133(11):2263-73.
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      110. King IN, Kathiriya IS, Murakami M, Nakagawa M, Gardner KA, Srivastava D, Nakagawa O. Hrt and Hes negatively regulate Notch signaling through interactions with RBP-Jkappa. Biochem Biophys Res Commun. 2006 Jun 23; 345(1):446-52.
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      111. Yamagishi C, Yamagishi H, Maeda J, Tsuchihashi T, Ivey K, Hu T, Srivastava D. Sonic hedgehog is essential for first pharyngeal arch development. Pediatr Res. 2006 Mar; 59(3):349-54.
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      112. Maeda J, Yamagishi H, McAnally J, Yamagishi C, Srivastava D. Tbx1 is regulated by forkhead proteins in the secondary heart field. Dev Dyn. 2006 Mar; 235(3):701-10.
        View in: PubMed PMC3316489
      113. Srivastava D. Genetic regulation of cardiogenesis and congenital heart disease. Annu Rev Pathol. 2006; 1:199-213.
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      114. Gong B, Trent MB, Srivastava D, Boor PJ. Chemical-induced, nonlethal, developmental model of dissecting aortic aneurysm. Birth Defects Res A Clin Mol Teratol. 2006 Jan; 76(1):29-38.
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      115. Koshiba-Takeuchi K, Takeuchi JK, Arruda EP, Kathiriya IS, Mo R, Hui CC, Srivastava D, Bruneau BG. Cooperative and antagonistic interactions between Sall4 and Tbx5 pattern the mouse limb and heart. Nat Genet. 2006 Feb; 38(2):175-83.
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      116. Kwon C, Han Z, Olson EN, Srivastava D. MicroRNA1 influences cardiac differentiation in Drosophila and regulates Notch signaling. Proc Natl Acad Sci U S A. 2005 Dec 27; 102(52):18986-91.
        View in: PubMed PMC1315275
      117. Kumar A, Nadig M, Patra V, Srivastava DN, Verma K, Bal CS. Adrenal and renal metastases from follicular thyroid cancer. Br J Radiol. 2005 Nov; 78(935):1038-41.
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      118. Costantini DL, Arruda EP, Agarwal P, Kim KH, Zhu Y, Zhu W, Lebel M, Cheng CW, Park CY, Pierce SA, Guerchicoff A, Pollevick GD, Chan TY, Kabir MG, Cheng SH, Husain M, Antzelevitch C, Srivastava D, Gross GJ, Hui CC, Backx PH, Bruneau BG. The homeodomain transcription factor Irx5 establishes the mouse cardiac ventricular repolarization gradient. Cell. 2005 Oct 21; 123(2):347-58.
        View in: PubMed PMC1480411
      119. Garg V, Muth AN, Ransom JF, Schluterman MK, Barnes R, King IN, Grossfeld PD, Srivastava D. Mutations in NOTCH1 cause aortic valve disease. Nature. 2005 Sep 8; 437(7056):270-4.
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      120. Zhao Y, Samal E, Srivastava D. Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesis. Nature. 2005 Jul 14; 436(7048):214-20.
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      121. Aiyer AR, Honarpour N, Herz J, Srivastava D. Loss of Apaf-1 leads to partial rescue of the HAND2-null phenotype. Dev Biol. 2005 Feb 1; 278(1):155-62.
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      122. Garg V, Srivastava D. Principles of Molecular Cardiology (Runge MS, Patterson C, Eds). Genetic underpinnings of cardiogenesis and congenital heart disease. 2005.
      123. McFadden DG, Barbosa AC, Richardson JA, Schneider MD, Srivastava D, Olson EN. The Hand1 and Hand2 transcription factors regulate expansion of the embryonic cardiac ventricles in a gene dosage-dependent manner. Development. 2005 Jan; 132(1):189-201.
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      124. Bock-Marquette I, Saxena A, White MD, Dimaio JM, Srivastava D. Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair. Nature. 2004 Nov 25; 432(7016):466-72.
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      125. Kathiriya IS, King IN, Murakami M, Nakagawa M, Astle JM, Gardner KA, Gerard RD, Olson EN, Srivastava D, Nakagawa O. Hairy-related transcription factors inhibit GATA-dependent cardiac gene expression through a signal-responsive mechanism. J Biol Chem. 2004 Dec 24; 279(52):54937-43.
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      126. Hu T, Yamagishi H, Maeda J, McAnally J, Yamagishi C, Srivastava D. Tbx1 regulates fibroblast growth factors in the anterior heart field through a reinforcing autoregulatory loop involving forkhead transcription factors. Development. 2004 Nov; 131(21):5491-502.
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      127. Cowan CA, Yokoyama N, Saxena A, Chumley MJ, Silvany RE, Baker LA, Srivastava D, Henkemeyer M. Ephrin-B2 reverse signaling is required for axon pathfinding and cardiac valve formation but not early vascular development. Dev Biol. 2004 Jul 15; 271(2):263-71.
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      128. Srivastava D. Heart disease: an ongoing genetic battle? Nature. 2004 Jun 24; 429(6994):819-22.
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      129. Srivastava D, Olson EN. Molecular Basis of Cardiovascular Disease: A Companion to Braunwald's Heart Disease (Chien KR, Ed). Cardiac Development and Congenital Heart Disease. 2004.
      130. Yamagishi H, Srivastava D. Unraveling the genetic and developmental mysteries of 22q11 deletion syndrome. Trends Mol Med. 2003 Sep; 9(9):383-9.
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      131. Garg V, Kathiriya IS, Barnes R, Schluterman MK, King IN, Butler CA, Rothrock CR, Eapen RS, Hirayama-Yamada K, Joo K, Matsuoka R, Cohen JC, Srivastava D. GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5. Nature. 2003 Jul 24; 424(6947):443-7.
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      132. Ivey K, Tyson B, Ukidwe P, McFadden DG, Levi G, Olson EN, Srivastava D, Wilkie TM. Galphaq and Galpha11 proteins mediate endothelin-1 signaling in neural crest-derived pharyngeal arch mesenchyme. Dev Biol. 2003 Mar 15; 255(2):230-7.
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      133. Yamagishi C, Hierck BP, Gittenberger-De Groot AC, Yamagishi H, Srivastava D. Functional attenuation of UFD1l, a 22q11.2 deletion syndrome candidate gene, leads to cardiac outflow septation defects in chicken embryos. Pediatr Res. 2003 Apr; 53(4):546-53.
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      134. Yamagishi H, Maeda J, Hu T, McAnally J, Conway SJ, Kume T, Meyers EN, Yamagishi C, Srivastava D. Tbx1 is regulated by tissue-specific forkhead proteins through a common Sonic hedgehog-responsive enhancer. Genes Dev. 2003 Jan 15; 17(2):269-81.
        View in: PubMed PMC195981
      135. Srivastava D. Building a heart: implications for congenital heart disease. J Nucl Cardiol. 2003 Jan-Feb; 10(1):63-70.
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      136. Srivastava D. Handbook of Cell Signaling (Bradshaw RA, Dennis EA, Eds). Signaling Pathways Involved in Cardiogenesis. 2003; 3:463–470.
      137. Villanueva MP, Aiyer AR, Muller S, Pletcher MT, Liu X, Emanuel B, Srivastava D, Reeves RH. Genetic and comparative mapping of genes dysregulated in mouse hearts lacking the Hand2 transcription factor gene. Genomics. 2002 Dec; 80(6):593-600.
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      138. Abe M, Tamamura Y, Yamagishi H, Maeda T, Kato J, Tabata MJ, Srivastava D, Wakisaka S, Kurisu K. Tooth-type specific expression of dHAND/Hand2: possible involvement in murine lower incisor morphogenesis. Cell Tissue Res. 2002 Nov; 310(2):201-12.
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      139. Gottlieb PD, Pierce SA, Sims RJ, Yamagishi H, Weihe EK, Harriss JV, Maika SD, Kuziel WA, King HL, Olson EN, Nakagawa O, Srivastava D. Bop encodes a muscle-restricted protein containing MYND and SET domains and is essential for cardiac differentiation and morphogenesis. Nat Genet. 2002 May; 31(1):25-32.
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      140. Srivastava D, Gottlieb PD, Olson EN. Molecular mechanisms of ventricular hypoplasia. Cold Spring Harb Symp Quant Biol. 2002; 67:121-5.
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      141. Srivastava D. Neonatal Cardiology (Artman M, Mahony L, Teitel DF, Eds). Molecular and morphogenetic cardiac embryology: Implications for congenital heart disease. 2002; 1–15.
      142. Yamagishi H, Yamagishi C, Nakagawa O, Harvey RP, Olson EN, Srivastava D. The combinatorial activities of Nkx2.5 and dHAND are essential for cardiac ventricle formation. Dev Biol. 2001 Nov 15; 239(2):190-203.
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      143. Kunte A, Ivey K, Yamagishi C, Garg V, Yamagishi H, Srivastava D. A common cis-acting sequence in the DiGeorge critical region regulates bi-directional transcription of UFD1L and CDC45L. Mech Dev. 2001 Oct; 108(1-2):81-92.
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      144. Natarajan A, Yamagishi H, Ahmad F, Li D, Roberts R, Matsuoka R, Hill S, Srivastava D. Human eHAND, but not dHAND, is down-regulated in cardiomyopathies. J Mol Cell Cardiol. 2001 Sep; 33(9):1607-14.
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      145. Kumar A, Bansal M, Srivastava DN, Pandhi A, Menon A, Mehra NK, Malaviya AN. Long-term outcome of undifferentiated spondylarthropathy. Rheumatol Int. 2001 Aug; 20(6):221-4.
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      146. Garg V, Yamagishi C, Hu T, Kathiriya IS, Yamagishi H, Srivastava D. Tbx1, a DiGeorge syndrome candidate gene, is regulated by sonic hedgehog during pharyngeal arch development. Dev Biol. 2001 Jul 1; 235(1):62-73.
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      147. Liu ZP, Nakagawa O, Nakagawa M, Yanagisawa H, Passier R, Richardson JA, Srivastava D, Olson EN. CHAMP, a novel cardiac-specific helicase regulated by MEF2C. Dev Biol. 2001 Jun 15; 234(2):497-509.
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      148. Srivastava D. Genetic assembly of the heart: implications for congenital heart disease. Annu Rev Physiol. 2001; 63:451-69.
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      149. Srivastava D, Baldwin HS. Moss and Adams' Heart Disease in Infants, Children, and Adolescents (Allen HD, Gutsgell HP, Clark EB, Driscoll DJ, Eds). Molecular determinants of cardiac development. 2001.
      150. Olson EN, Srivastava D. Encyclopedia of Molecular Medicine (Creighton TE and Kazazian HH, Eds). HAND transcription factors. 2001.
      151. Nakagawa O, McFadden DG, Nakagawa M, Yanagisawa H, Hu T, Srivastava D, Olson EN. Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling. Proc Natl Acad Sci U S A. 2000 Dec 5; 97(25):13655-60.
        View in: PubMed PMC17631
      152. McFadden DG, Charité J, Richardson JA, Srivastava D, Firulli AB, Olson EN. A GATA-dependent right ventricular enhancer controls dHAND transcription in the developing heart. Development. 2000 Dec; 127(24):5331-41.
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      153. Fisher SA, Langille BL, Srivastava D. Apoptosis during cardiovascular development. Circ Res. 2000 Nov 10; 87(10):856-64.
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      154. Srivastava D, Olson EN. A genetic blueprint for cardiac development. Nature. 2000 Sep 14; 407(6801):221-6.
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      155. Angelo S, Lohr J, Lee KH, Ticho BS, Breitbart RE, Hill S, Yost HJ, Srivastava D. Conservation of sequence and expression of Xenopus and zebrafish dHAND during cardiac, branchial arch and lateral mesoderm development. Mech Dev. 2000 Jul; 95(1-2):231-7.
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      156. Srivastava D. Congenital heart defects: trapping the genetic culprits. Circ Res. 2000 May 12; 86(9):917-8.
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      157. Fernandez-Teran M, Piedra ME, Kathiriya IS, Srivastava D, Rodriguez-Rey JC, Ros MA. Role of dHAND in the anterior-posterior polarization of the limb bud: implications for the Sonic hedgehog pathway. Development. 2000 May; 127(10):2133-42.
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      158. Yamagishi H, Olson EN, Srivastava D. The basic helix-loop-helix transcription factor, dHAND, is required for vascular development. J Clin Invest. 2000 Feb; 105(3):261-70.
        View in: PubMed PMC377450
      159. Yamagishi H, Srivastava D. Etiology and Morphogenesis of Congenital Heart Disease (Clark EB, Nakazawa M, Takao A, Eds). Role of the bHLH transcription factor, dHAND, in cranial/cardiac neural crest development. 2000; 325–328.
      160. Srivastava D. Etiology and Morphogenesis of Congenital Heart Disease (Takao A, Nakazawa M, Clark EB, Eds). Understanding CHD through dissection of segmental cardiac molecular pathways. 2000; 205–210.
      161. Kathiriya IS, Srivastava D. Left-right asymmetry and cardiac looping: implications for cardiac development and congenital heart disease. Am J Med Genet. 2000; 97(4):271-9.
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      162. Srivastava D. DiGeorge syndrome: an enigma in mice and men. Mol Med Today. 2000 Jan; 6(1):13-4.
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      163. Nakagawa O, Nakagawa M, Richardson JA, Olson EN, Srivastava D. HRT1, HRT2, and HRT3: a new subclass of bHLH transcription factors marking specific cardiac, somitic, and pharyngeal arch segments. Dev Biol. 1999 Dec 1; 216(1):72-84.
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      164. Srivastava D. Developmental and genetic aspects of congenital heart disease. Curr Opin Cardiol. 1999 May; 14(3):263-8.
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      165. Yamagishi H, Garg V, Matsuoka R, Thomas T, Srivastava D. A molecular pathway revealing a genetic basis for human cardiac and craniofacial defects. Science. 1999 Feb 19; 283(5405):1158-61.
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      166. Srivastava D. Heart Development (Rosenthal N and Harvey R, Eds). Segmental regulation of cardiac development by the basic helix-loop-helix transcription factors dHAND and eHAND. 1999; 143–155.
      167. Srivastava D. HAND proteins: molecular mediators of cardiac development and congenital heart disease. Trends Cardiovasc Med. 1999 Jan-Feb; 9(1-2):11-8.
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      168. Thomas T, Kurihara H, Yamagishi H, Kurihara Y, Yazaki Y, Olson EN, Srivastava D. A signaling cascade involving endothelin-1, dHAND and msx1 regulates development of neural-crest-derived branchial arch mesenchyme. Development. 1998 Aug; 125(16):3005-14.
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      169. Thomas T, Yamagishi H, Overbeek PA, Olson EN, Srivastava D. The bHLH factors, dHAND and eHAND, specify pulmonary and systemic cardiac ventricles independent of left-right sidedness. Dev Biol. 1998 Apr 15; 196(2):228-36.
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      170. Firulli AB, McFadden DG, Lin Q, Srivastava D, Olson EN. Heart and extra-embryonic mesodermal defects in mouse embryos lacking the bHLH transcription factor Hand1. Nat Genet. 1998 Mar; 18(3):266-70.
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      171. Srivastava D. Left, right ... which way to turn? Nat Genet. 1997 Nov; 17(3):252-4.
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      172. Srivastava D, Olson EN. Knowing in your heart what's right. Trends Cell Biol. 1997 Nov; 7(11):447-53.
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      173. Srivastava D, Thomas T, Lin Q, Kirby ML, Brown D, Olson EN. Regulation of cardiac mesodermal and neural crest development by the bHLH transcription factor, dHAND. Nat Genet. 1997 Jun; 16(2):154-60.
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      174. Srivastava D. Genetic Control of Heart Development (Harvey RP, Olson EN, Schulz RA, Altman JS, Eds). The bHLH proteins, dHAND and eHAND in cardiac development. 1997.
      175. Lin Q, Srivastava D, Olson EN. A transcriptional pathway for cardiac development. Cold Spring Harb Symp Quant Biol. 1997; 62:405-11.
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      176. Srivastava D, Olson EN. Neurotrophin-3 knocks heart off Trk. Nat Med. 1996 Oct; 2(10):1069-71.
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      177. Olson EN, Srivastava D. Molecular pathways controlling heart development. Science. 1996 May 3; 272(5262):671-6.
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      178. Srivastava D, Cserjesi P, Olson EN. A subclass of bHLH proteins required for cardiac morphogenesis. Science. 1995 Dec 22; 270(5244):1995-9.
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      179. Srivastava D, Preminger T, Lock JE, Mandell V, Keane JF, Mayer JE, Kozakewich H, Spevak PJ. Hepatic venous blood and the development of pulmonary arteriovenous malformations in congenital heart disease. Circulation. 1995 Sep 1; 92(5):1217-22.
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      180. Srivastava D, Thompson EB. Two glucocorticoid binding sites on the human glucocorticoid receptor. Endocrinology. 1990 Oct; 127(4):1770-8.
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      181. Thompson EB, Srivastava D, Johnson BH. Interactions of the phenylpyrazolo steroid cortivazol with glucocorticoid receptors in steroid-sensitive and -resistant human leukemic cells. Cancer Res. 1989 Apr 15; 49(8 Suppl):2253s-2258s.
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