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    Deepak Srivastava

    TitleProfessor
    SchoolUCSF School of Medicine
    DepartmentPediatrics
    Address1650 Owens St, Mission Bay
    San Francisco CA 94158
    Phone415-734-2716

       Overview 
       Overview
      Our laboratory focuses on understanding the causes of heart disease and on using knowledge of cardiac developmental pathways to devise novel therapeutic approaches for human cardiac disorders. Specifically, we study the molecular events regulating early and late developmental decisions that instruct progenitor cells to adopt a cardiac cell fate and subsequently fashion a functioning heart. We focus on transcriptional and post-transcriptional steps, including those involving microRNAs. We have leveraged this knowledge to reprogram fibroblasts directly into cardiomyocyte-like cells for regenerative purposes. We also seek to identify the causes of human cardiovascular disease by applying modern genetic technologies for the study of complex traits such as congenital heart disease. By using a spectrum of approaches including mouse and human genetics, molecular and developmental biology, and biochemistry we hope to develop a broad understanding of the biology underlying cardiogenesis and cardiovascular disorders.


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       Bibliographic 
       Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Heidersbach A, Saxby C, Carver-Moore K, Huang Y, Ang YS, de Jong PJ, Ivey KN, Srivastava D. microRNA-1 regulates sarcomere formation and suppresses smooth muscle gene expression in the mammalian heart. Elife. 2013; 2(0).
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      2. Worringer KA, Rand TA, Hayashi Y, Sami S, Takahashi K, Tanabe K, Narita M, Srivastava D, Yamanaka S. The let-7/LIN-41 Pathway Regulates Reprogramming to Human Induced Pluripotent Stem Cells by Controlling Expression of Prodifferentiation Genes. Cell Stem Cell. 2014 Jan 2; 14(1):40-52.
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      3. Qian L, Srivastava D. Direct cardiac reprogramming: from developmental biology to cardiac regeneration. Circ Res. 2013 Sep 13; 113(7):915-21.
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      4. Srivastava D, Berry EC. Cardiac reprogramming: from mouse toward man. Curr Opin Genet Dev. 2013 Oct; 23(5):574-8.
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      5. Fu JD, Stone NR, Liu L, Spencer CI, Qian L, Hayashi Y, Delgado-Olguin P, Ding S, Bruneau BG, Srivastava D. Direct Reprogramming of Human Fibroblasts toward a Cardiomyocyte-like State. Stem Cell Reports. 2013; 1(3):235-47.
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      6. Cheng P, Andersen P, Hassel D, Kaynak BL, Limphong P, Juergensen L, Kwon C, Srivastava D. Fibronectin mediates mesendodermal cell fate decisions. Development. 2013 Jun; 140(12):2587-96.
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      7. Qian L, Berry EC, Fu JD, Ieda M, Srivastava D. Reprogramming of mouse fibroblasts into cardiomyocyte-like cells in vitro. Nat Protoc. 2013 Jun; 8(6):1204-15.
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      8. Srivastava D, Heidersbach AJ. Small solutions to big problems: microRNAs for cardiac regeneration. Circ Res. 2013 May 24; 112(11):1412-4.
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      9. Spindler MJ, Burmeister BT, Huang Y, Hsiao EC, Salomonis N, Scott MJ, Srivastava D, Carnegie GK, Conklin BR. AKAP13 Rho-GEF and PKD-binding domain deficient mice develop normally but have an abnormal response to ß-adrenergic-induced cardiac hypertrophy. PLoS One. 2013; 8(4):e62705.
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      10. Srivastava D, Cordes Metzler KR. Fending for a Braveheart. EMBO J. 2013 May 2; 32(9):1211-3.
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      11. Limphong P, Zhang H, Christians E, Liu Q, Riedel M, Ivey K, Cheng P, Mitzelfelt K, Taylor G, Winge D, Srivastava D, Benjamin I. Modeling human protein aggregation cardiomyopathy using murine induced pluripotent stem cells. Stem Cells Transl Med. 2013 Mar; 2(3):161-6.
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      12. White MP, Rufaihah AJ, Liu L, Ghebremariam YT, Ivey KN, Cooke JP, Srivastava D. Limited gene expression variation in human embryonic stem cell and induced pluripotent stem cell-derived endothelial cells. Stem Cells. 2013 Jan; 31(1):92-103.
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      13. Plath K, Srivastava D, Alvarez-Buylla A, Tanaka EM, Kriegstein AR. Stem cells in the land of the rising sun: ISSCR 2012. Cell Stem Cell. 2012 Nov 2; 11(5):607-14.
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      14. Vedantham V, Evangelista M, Huang Y, Srivastava D. Spatiotemporal regulation of an Hcn4 enhancer defines a role for Mef2c and HDACs in cardiac electrical patterning. Dev Biol. 2013 Jan 1; 373(1):149-62.
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      15. Srivastava D, Ieda M, Fu J, Qian L. Cardiac repair with thymosin ß4 and cardiac reprogramming factors. Ann N Y Acad Sci. 2012 Oct; 1270:66-72.
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      16. Wamstad JA, Alexander JM, Truty RM, Shrikumar A, Li F, Eilertson KE, Ding H, Wylie JN, Pico AR, Capra JA, Erwin G, Kattman SJ, Keller GM, Srivastava D, Levine SS, Pollard KS, Holloway AK, Boyer LA, Bruneau BG. Dynamic and coordinated epigenetic regulation of developmental transitions in the cardiac lineage. Cell. 2012 Sep 28; 151(1):206-20.
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      17. Hassel D, Cheng P, White MP, Ivey KN, Kroll J, Augustin HG, Katus HA, Stainier DY, Srivastava D. MicroRNA-10 regulates the angiogenic behavior of zebrafish and human endothelial cells by promoting vascular endothelial growth factor signaling. Circ Res. 2012 Nov 9; 111(11):1421-33.
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      18. Tomoda K, Takahashi K, Leung K, Okada A, Narita M, Yamada NA, Eilertson KE, Tsang P, Baba S, White MP, Sami S, Srivastava D, Conklin BR, Panning B, Yamanaka S. Derivation conditions impact X-inactivation status in female human induced pluripotent stem cells. Cell Stem Cell. 2012 Jul 6; 11(1):91-9.
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      19. Srivastava D, Ieda M. Critical factors for cardiac reprogramming. Circ Res. 2012 Jun 22; 111(1):5-8.
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      20. Qian L, Huang Y, Spencer CI, Foley A, Vedantham V, Liu L, Conway SJ, Fu JD, Srivastava D. In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes. Nature. 2012 May 31; 485(7400):593-8.
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      21. Misra C, Sachan N, McNally CR, Koenig SN, Nichols HA, Guggilam A, Lucchesi PA, Pu WT, Srivastava D, Garg V. Congenital heart disease-causing Gata4 mutation displays functional deficits in vivo. PLoS Genet. 2012; 8(5):e1002690.
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      22. Park CY, Jeker LT, Carver-Moore K, Oh A, Liu HJ, Cameron R, Richards H, Li Z, Adler D, Yoshinaga Y, Martinez M, Nefadov M, Abbas AK, Weiss A, Lanier LL, de Jong PJ, Bluestone JA, Srivastava D, McManus MT. A resource for the conditional ablation of microRNAs in the mouse. Cell Rep. 2012 Apr 19; 1(4):385-91.
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      23. Kathiresan S, Srivastava D. Genetics of human cardiovascular disease. Cell. 2012 Mar 16; 148(6):1242-57.
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      24. Funato N, Nakamura M, Richardson JA, Srivastava D, Yanagisawa H. Tbx1 regulates oral epithelial adhesion and palatal development. Hum Mol Genet. 2012 Jun 1; 21(11):2524-37.
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      25. Bernstein HS, Srivastava D. Stem cell therapy for cardiac disease. Pediatr Res. 2012 Apr; 71(4 Pt 2):491-9.
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      26. Roach JC, Glusman G, Hubley R, Montsaroff SZ, Holloway AK, Mauldin DE, Srivastava D, Garg V, Pollard KS, Galas DJ, Hood L, Smit AF. Chromosomal haplotypes by genetic phasing of human families. Am J Hum Genet. 2011 Sep 9; 89(3):382-97.
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      27. Kwon C, Cheng P, King IN, Andersen P, Shenje L, Nigam V, Srivastava D. Notch post-translationally regulates ß-catenin protein in stem and progenitor cells. Nat Cell Biol. 2011 Oct; 13(10):1244-51.
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      28. AlRais F, Feldstein VA, Srivastava D, Gosnell K, Moon-Grady AJ. Monochorionic twins discordant for congenital heart disease: a referral center's experience and possible pathophysiologic mechanisms. Prenat Diagn. 2011 Oct; 31(10):978-84.
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      29. Qian L, Wythe JD, Liu J, Cartry J, Vogler G, Mohapatra B, Otway RT, Huang Y, King IN, Maillet M, Zheng Y, Crawley T, Taghli-Lamallem O, Semsarian C, Dunwoodie S, Winlaw D, Harvey RP, Fatkin D, Towbin JA, Molkentin JD, Srivastava D, Ocorr K, Bruneau BG, Bodmer R. Tinman/Nkx2-5 acts via miR-1 and upstream of Cdc42 to regulate heart function across species. J Cell Biol. 2011 Jun 27; 193(7):1181-96.
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      30. Shieh JT, Huang Y, Gilmore J, Srivastava D. Elevated miR-499 levels blunt the cardiac stress response. PLoS One. 2011; 6(5):e19481.
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      31. King IN, Qian L, Liang J, Huang Y, Shieh JT, Kwon C, Srivastava D. A genome-wide screen reveals a role for microRNA-1 in modulating cardiac cell polarity. Dev Cell. 2011 Apr 19; 20(4):497-510.
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      32. Fish JE, Wythe JD, Xiao T, Bruneau BG, Stainier DY, Srivastava D, Woo S. A Slit/miR-218/Robo regulatory loop is required during heart tube formation in zebrafish. Development. 2011 Apr; 138(7):1409-19.
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      33. Qian L, Van Laake LW, Huang Y, Liu S, Wendland MF, Srivastava D. miR-24 inhibits apoptosis and represses Bim in mouse cardiomyocytes. J Exp Med. 2011 Mar 14; 208(3):549-60.
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      34. Li Q, Kannan A, DeMayo FJ, Lydon JP, Cooke PS, Yamagishi H, Srivastava D, Bagchi MK, Bagchi IC. The antiproliferative action of progesterone in uterine epithelium is mediated by Hand2. Science. 2011 Feb 18; 331(6019):912-6.
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      35. Yu S, Crawford D, Tsuchihashi T, Behrens TW, Srivastava D. The chemokine receptor CXCR7 functions to regulate cardiac valve remodeling. Dev Dyn. 2011 Feb; 240(2):384-93.
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      36. Srivastava D. Rudplph's Pediatrics (Rudolph C, Rudolph A, Lister G, First L, Gershon A, Eds). Control of embryologic cardiac development. 2011.
      37. Tsuchihashi T, Maeda J, Shin CH, Ivey KN, Black BL, Olson EN, Yamagishi H, Srivastava D. Hand2 function in second heart field progenitors is essential for cardiogenesis. Dev Biol. 2011 Mar 1; 351(1):62-9.
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      38. Sheehy NT, Cordes KR, White MP, Ivey KN, Srivastava D. The neural crest-enriched microRNA miR-452 regulates epithelial-mesenchymal signaling in the first pharyngeal arch. Development. 2010 Dec; 137(24):4307-16.
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      39. Park CY, Pierce SA, von Drehle M, Ivey KN, Morgan JA, Blau HM, Srivastava D. skNAC, a Smyd1-interacting transcription factor, is involved in cardiac development and skeletal muscle growth and regeneration. Proc Natl Acad Sci U S A. 2010 Nov 30; 107(48):20750-5.
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      40. Maitra M, Koenig SN, Srivastava D, Garg V. Identification of GATA6 sequence variants in patients with congenital heart defects. Pediatr Res. 2010 Oct; 68(4):281-5.
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      41. Ieda M, Fu JD, Delgado-Olguin P, Vedantham V, Hayashi Y, Bruneau BG, Srivastava D. Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors. Cell. 2010 Aug 6; 142(3):375-86.
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      42. Ivey KN, Srivastava D. MicroRNAs as regulators of differentiation and cell fate decisions. Cell Stem Cell. 2010 Jul 2; 7(1):36-41.
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      43. Nigam V, Sievers HH, Jensen BC, Sier HA, Simpson PC, Srivastava D, Mohamed SA. Altered microRNAs in bicuspid aortic valve: a comparison between stenotic and insufficient valves. J Heart Valve Dis. 2010 Jul; 19(4):459-65.
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      44. van Laake LW, Qian L, Cheng P, Huang Y, Hsiao EC, Conklin BR, Srivastava D. Reporter-based isolation of induced pluripotent stem cell- and embryonic stem cell-derived cardiac progenitors reveals limited gene expression variance. Circ Res. 2010 Aug 6; 107(3):340-7.
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      45. Shrivastava S, Srivastava D, Olson EN, DiMaio JM, Bock-Marquette I. Thymosin beta4 and cardiac repair. Ann N Y Acad Sci. 2010 Apr; 1194:87-96.
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      46. Qian L, Srivastava D. Monkeying around with cardiac progenitors: hope for the future. J Clin Invest. 2010 Apr; 120(4):1034-6.
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      47. Cordes KR, Srivastava D, Ivey KN. MicroRNAs in cardiac development. Pediatr Cardiol. 2010 Apr; 31(3):349-56.
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      48. Cordes KR, Srivastava D. Heart Development and Regeneration (Rosenthal N, Harvey R, Eds). MicroRNA regulation of cardiac development and disease. 2010; 2:729–740.
      49. Bruneau BG, Burn J, Srivastava D. Paediatric Cardiology (Anderson RH, Baker EJ, Penny D, Redington AN, Rigby ML, Wernovsky G, Eds). The Aetiology of Congenital Cardiac Disease. 2010; 161–171.
      50. Fish JE, Yan MS, Matouk CC, St Bernard R, Ho JJ, Ho JJ, Gavryushova A, Srivastava D, Marsden PA. Hypoxic repression of endothelial nitric-oxide synthase transcription is coupled with eviction of promoter histones. J Biol Chem. 2010 Jan 8; 285(2):810-26.
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      51. Nigam V, Srivastava D. Notch1 represses osteogenic pathways in aortic valve cells. J Mol Cell Cardiol. 2009 Dec; 47(6):828-34.
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      52. Kwon C, Qian L, Cheng P, Nigam V, Arnold J, Srivastava D. A regulatory pathway involving Notch1/beta-catenin/Isl1 determines cardiac progenitor cell fate. Nat Cell Biol. 2009 Aug; 11(8):951-7.
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      53. Shieh JT, Srivastava D. Heart malformation: what are the chances it could happen again? Circulation. 2009 Jul 28; 120(4):269-71.
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      54. Cordes KR, Sheehy NT, White MP, Berry EC, Morton SU, Muth AN, Lee TH, Miano JM, Ivey KN, Srivastava D. miR-145 and miR-143 regulate smooth muscle cell fate and plasticity. Nature. 2009 Aug 6; 460(7256):705-10.
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      55. Bock-Marquette I, Shrivastava S, Pipes GC, Thatcher JE, Blystone A, Shelton JM, Galindo CL, Melegh B, Srivastava D, Olson EN, DiMaio JM. Thymosin beta4 mediated PKC activation is essential to initiate the embryonic coronary developmental program and epicardial progenitor cell activation in adult mice in vivo. J Mol Cell Cardiol. 2009 May; 46(5):728-38.
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      56. Cordes KR, Srivastava D. MicroRNA regulation of cardiovascular development. Circ Res. 2009 Mar 27; 104(6):724-32.
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      57. Ellis J, Bruneau BG, Keller G, Lemischka IR, Nagy A, Rossant J, Srivastava D, Zandstra PW, Stanford WL. Alternative induced pluripotent stem cell characterization criteria for in vitro applications. Cell Stem Cell. 2009 Mar 6; 4(3):198-9; author reply 202.
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      58. Ieda M, Tsuchihashi T, Ivey KN, Ross RS, Hong TT, Shaw RM, Srivastava D. Cardiac fibroblasts regulate myocardial proliferation through beta1 integrin signaling. Dev Cell. 2009 Feb; 16(2):233-44.
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      59. Fish JE, Srivastava D. MicroRNAs: opening a new vein in angiogenesis research. Sci Signal. 2009 Jan 6; 2(52):pe1.
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      60. Srivastava D, Kwon C. Handbook of Cell Signaling (Bradshaw RA, Dennis EA, Eds). Signaling pathways involved in cardiogenesis. 2009; 3:2601–2609.
      61. Kwon C, Cordes KR, Srivastava D. Wnt/beta-catenin signaling acts at multiple developmental stages to promote mammalian cardiogenesis. Cell Cycle. 2008 Dec 15; 7(24):3815-8.
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      62. Maitra M, Schluterman MK, Nichols HA, Richardson JA, Lo CW, Srivastava D, Garg V. Interaction of Gata4 and Gata6 with Tbx5 is critical for normal cardiac development. Dev Biol. 2009 Feb 15; 326(2):368-77.
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      63. Morton SU, Scherz PJ, Cordes KR, Ivey KN, Stainier DY, Srivastava D. microRNA-138 modulates cardiac patterning during embryonic development. Proc Natl Acad Sci U S A. 2008 Nov 18; 105(46):17830-5.
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      64. Niu Z, Iyer D, Conway SJ, Martin JF, Ivey K, Srivastava D, Nordheim A, Schwartz RJ. Serum response factor orchestrates nascent sarcomerogenesis and silences the biomineralization gene program in the heart. Proc Natl Acad Sci U S A. 2008 Nov 18; 105(46):17824-9.
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      65. Ransom JF, King IN, Garg V, Srivastava D. A rare human sequence variant reveals myocardin autoinhibition. J Biol Chem. 2008 Dec 19; 283(51):35845-52.
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      66. Penzes P, Cahill ME, Jones KA, Srivastava DP. Convergent CaMK and RacGEF signals control dendritic structure and function. Trends Cell Biol. 2008 Sep; 18(9):405-13.
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      67. Fish JE, Santoro MM, Morton SU, Yu S, Yeh RF, Wythe JD, Ivey KN, Bruneau BG, Stainier DY, Srivastava D. miR-126 regulates angiogenic signaling and vascular integrity. Dev Cell. 2008 Aug; 15(2):272-84.
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      68. Ivey KN, Sutcliffe D, Richardson J, Clyman RI, Garcia JA, Srivastava D. Transcriptional regulation during development of the ductus arteriosus. Circ Res. 2008 Aug 15; 103(4):388-95.
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      69. Saxena A, Fish JE, White MD, Yu S, Smyth JW, Shaw RM, DiMaio JM, Srivastava D. Stromal cell-derived factor-1alpha is cardioprotective after myocardial infarction. Circulation. 2008 Apr 29; 117(17):2224-31.
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      70. Ivey KN, Muth A, Arnold J, King FW, Yeh RF, Fish JE, Hsiao EC, Schwartz RJ, Conklin BR, Bernstein HS, Srivastava D. MicroRNA regulation of cell lineages in mouse and human embryonic stem cells. Cell Stem Cell. 2008 Mar 6; 2(3):219-29.
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      71. Gong B, Sun J, Vargas G, Chang Q, Xu Y, Srivastava D, Boor PJ. Nonlinear imaging study of extracellular matrix in chemical-induced, developmental dissecting aortic aneurysm: evidence for defective collagen type III. Birth Defects Res A Clin Mol Teratol. 2008 Jan; 82(1):16-24.
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      72. Nigam V, Srivastava D. Inborn Errors of Development (Epstein CJ, Ed). Molecular regulation of cardiogenesis. 2008; 124–129.
      73. Jia H, King IN, Chopra SS, Wan H, Ni TT, Jiang C, Guan X, Wells S, Srivastava D, Zhong TP. Vertebrate heart growth is regulated by functional antagonism between Gridlock and Gata5. Proc Natl Acad Sci U S A. 2007 Aug 28; 104(35):14008-13.
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      74. Srivastava D, Saxena A, Michael Dimaio J, Bock-Marquette I. Thymosin beta4 is cardioprotective after myocardial infarction. Ann N Y Acad Sci. 2007 Sep; 1112:161-70.
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      75. Rajagopal SK, Ma Q, Obler D, Shen J, Manichaikul A, Tomita-Mitchell A, Boardman K, Briggs C, Garg V, Srivastava D, Goldmuntz E, Broman KW, Benson DW, Smoot LB, Pu WT. Spectrum of heart disease associated with murine and human GATA4 mutation. J Mol Cell Cardiol. 2007 Dec; 43(6):677-85.
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      76. Kwon C, Arnold J, Hsiao EC, Taketo MM, Conklin BR, Srivastava D. Canonical Wnt signaling is a positive regulator of mammalian cardiac progenitors. Proc Natl Acad Sci U S A. 2007 Jun 26; 104(26):10894-9.
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      77. Pierpont ME, Basson CT, Benson DW, Gelb BD, Giglia TM, Goldmuntz E, McGee G, Sable CA, Srivastava D, Webb CL. Genetic basis for congenital heart defects: current knowledge: a scientific statement from the American Heart Association Congenital Cardiac Defects Committee, Council on Cardiovascular Disease in the Young: endorsed by the American Academy of Pediatrics. Circulation. 2007 Jun 12; 115(23):3015-38.
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      78. Xin M, Small EM, van Rooij E, Qi X, Richardson JA, Srivastava D, Nakagawa O, Olson EN. Essential roles of the bHLH transcription factor Hrt2 in repression of atrial gene expression and maintenance of postnatal cardiac function. Proc Natl Acad Sci U S A. 2007 May 8; 104(19):7975-80.
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      79. Schluterman MK, Krysiak AE, Kathiriya IS, Abate N, Chandalia M, Srivastava D, Garg V. Screening and biochemical analysis of GATA4 sequence variations identified in patients with congenital heart disease. Am J Med Genet A. 2007 Apr 15; 143A(8):817-23.
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      80. Zhao Y, Ransom JF, Li A, Vedantham V, von Drehle M, Muth AN, Tsuchihashi T, McManus MT, Schwartz RJ, Srivastava D. Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2. Cell. 2007 Apr 20; 129(2):303-17.
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      81. Zhao Y, Srivastava D. A developmental view of microRNA function. Trends Biochem Sci. 2007 Apr; 32(4):189-97.
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      82. Samal E, Srivastava D. Advances in Developmental Biology (Bodmer R, Ed). Role of microRNAs in Cardiovascular Biology. 2007; 18:167–178.
      83. Ransom J, Srivastava D. The genetics of cardiac birth defects. Semin Cell Dev Biol. 2007 Feb; 18(1):132-9.
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      84. Ivey KN, Srivastava D. The paradoxical patent ductus arteriosus. J Clin Invest. 2006 Nov; 116(11):2863-5.
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      85. Ramana KV, Willis MS, White MD, Horton JW, DiMaio JM, Srivastava D, Bhatnagar A, Srivastava SK. Endotoxin-induced cardiomyopathy and systemic inflammation in mice is prevented by aldose reductase inhibition. Circulation. 2006 Oct 24; 114(17):1838-46.
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      86. Srivastava D. Making or breaking the heart: from lineage determination to morphogenesis. Cell. 2006 Sep 22; 126(6):1037-48.
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      87. Srivastava D, Yu S. Stretching to meet needs: integrin-linked kinase and the cardiac pump. Genes Dev. 2006 Sep 1; 20(17):2327-31.
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      88. Srivastava D, Ivey KN. Potential of stem-cell-based therapies for heart disease. Nature. 2006 Jun 29; 441(7097):1097-9.
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      89. Capellini TD, Di Giacomo G, Salsi V, Brendolan A, Ferretti E, Srivastava D, Zappavigna V, Selleri L. Pbx1/Pbx2 requirement for distal limb patterning is mediated by the hierarchical control of Hox gene spatial distribution and Shh expression. Development. 2006 Jun; 133(11):2263-73.
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      90. King IN, Kathiriya IS, Murakami M, Nakagawa M, Gardner KA, Srivastava D, Nakagawa O. Hrt and Hes negatively regulate Notch signaling through interactions with RBP-Jkappa. Biochem Biophys Res Commun. 2006 Jun 23; 345(1):446-52.
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      91. Maeda J, Yamagishi H, McAnally J, Yamagishi C, Srivastava D. Tbx1 is regulated by forkhead proteins in the secondary heart field. Dev Dyn. 2006 Mar; 235(3):701-10.
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      92. Yamagishi C, Yamagishi H, Maeda J, Tsuchihashi T, Ivey K, Hu T, Srivastava D. Sonic hedgehog is essential for first pharyngeal arch development. Pediatr Res. 2006 Mar; 59(3):349-54.
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      93. Gong B, Trent MB, Srivastava D, Boor PJ. Chemical-induced, nonlethal, developmental model of dissecting aortic aneurysm. Birth Defects Res A Clin Mol Teratol. 2006 Jan; 76(1):29-38.
        View in: PubMed
      94. Srivastava D. Genetic regulation of cardiogenesis and congenital heart disease. Annu Rev Pathol. 2006; 1:199-213.
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      95. Koshiba-Takeuchi K, Takeuchi JK, Arruda EP, Kathiriya IS, Mo R, Hui CC, Srivastava D, Bruneau BG. Cooperative and antagonistic interactions between Sall4 and Tbx5 pattern the mouse limb and heart. Nat Genet. 2006 Feb; 38(2):175-83.
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      96. Kwon C, Han Z, Olson EN, Srivastava D. MicroRNA1 influences cardiac differentiation in Drosophila and regulates Notch signaling. Proc Natl Acad Sci U S A. 2005 Dec 27; 102(52):18986-91.
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      97. Costantini DL, Arruda EP, Agarwal P, Kim KH, Zhu Y, Zhu W, Lebel M, Cheng CW, Park CY, Pierce SA, Guerchicoff A, Pollevick GD, Chan TY, Kabir MG, Cheng SH, Husain M, Antzelevitch C, Srivastava D, Gross GJ, Hui CC, Backx PH, Bruneau BG. The homeodomain transcription factor Irx5 establishes the mouse cardiac ventricular repolarization gradient. Cell. 2005 Oct 21; 123(2):347-58.
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      98. Garg V, Muth AN, Ransom JF, Schluterman MK, Barnes R, King IN, Grossfeld PD, Srivastava D. Mutations in NOTCH1 cause aortic valve disease. Nature. 2005 Sep 8; 437(7056):270-4.
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      99. Zhao Y, Samal E, Srivastava D. Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesis. Nature. 2005 Jul 14; 436(7048):214-20.
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      100. Aiyer AR, Honarpour N, Herz J, Srivastava D. Loss of Apaf-1 leads to partial rescue of the HAND2-null phenotype. Dev Biol. 2005 Feb 1; 278(1):155-62.
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      101. Garg V, Srivastava D. Principles of Molecular Cardiology (Runge MS, Patterson C, Eds). Genetic underpinnings of cardiogenesis and congenital heart disease. 2005.
      102. McFadden DG, Barbosa AC, Richardson JA, Schneider MD, Srivastava D, Olson EN. The Hand1 and Hand2 transcription factors regulate expansion of the embryonic cardiac ventricles in a gene dosage-dependent manner. Development. 2005 Jan; 132(1):189-201.
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      103. Bock-Marquette I, Saxena A, White MD, Dimaio JM, Srivastava D. Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair. Nature. 2004 Nov 25; 432(7016):466-72.
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      104. Kathiriya IS, King IN, Murakami M, Nakagawa M, Astle JM, Gardner KA, Gerard RD, Olson EN, Srivastava D, Nakagawa O. Hairy-related transcription factors inhibit GATA-dependent cardiac gene expression through a signal-responsive mechanism. J Biol Chem. 2004 Dec 24; 279(52):54937-43.
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      105. Hu T, Yamagishi H, Maeda J, McAnally J, Yamagishi C, Srivastava D. Tbx1 regulates fibroblast growth factors in the anterior heart field through a reinforcing autoregulatory loop involving forkhead transcription factors. Development. 2004 Nov; 131(21):5491-502.
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      106. Cowan CA, Yokoyama N, Saxena A, Chumley MJ, Silvany RE, Baker LA, Srivastava D, Henkemeyer M. Ephrin-B2 reverse signaling is required for axon pathfinding and cardiac valve formation but not early vascular development. Dev Biol. 2004 Jul 15; 271(2):263-71.
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      107. Srivastava D. Heart disease: an ongoing genetic battle? Nature. 2004 Jun 24; 429(6994):819-22.
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      108. Srivastava D, Olson EN. Molecular Basis of Cardiovascular Disease: A Companion to Braunwald's Heart Disease (Chien KR, Ed). Cardiac Development and Congenital Heart Disease. 2004.
      109. Yamagishi H, Srivastava D. Unraveling the genetic and developmental mysteries of 22q11 deletion syndrome. Trends Mol Med. 2003 Sep; 9(9):383-9.
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      110. Garg V, Kathiriya IS, Barnes R, Schluterman MK, King IN, Butler CA, Rothrock CR, Eapen RS, Hirayama-Yamada K, Joo K, Matsuoka R, Cohen JC, Srivastava D. GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5. Nature. 2003 Jul 24; 424(6947):443-7.
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      111. Ivey K, Tyson B, Ukidwe P, McFadden DG, Levi G, Olson EN, Srivastava D, Wilkie TM. Galphaq and Galpha11 proteins mediate endothelin-1 signaling in neural crest-derived pharyngeal arch mesenchyme. Dev Biol. 2003 Mar 15; 255(2):230-7.
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      112. Yamagishi C, Hierck BP, Gittenberger-De Groot AC, Yamagishi H, Srivastava D. Functional attenuation of UFD1l, a 22q11.2 deletion syndrome candidate gene, leads to cardiac outflow septation defects in chicken embryos. Pediatr Res. 2003 Apr; 53(4):546-53.
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      113. Yamagishi H, Maeda J, Hu T, McAnally J, Conway SJ, Kume T, Meyers EN, Yamagishi C, Srivastava D. Tbx1 is regulated by tissue-specific forkhead proteins through a common Sonic hedgehog-responsive enhancer. Genes Dev. 2003 Jan 15; 17(2):269-81.
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      114. He F, Yang XP, Srivastava DK, Wilson SH. DNA polymerase beta gene expression: the promoter activator CREB-1 is upregulated in Chinese hamster ovary cells by DNA alkylating agent-induced stress. Biol Chem. 2003 Jan; 384(1):19-23.
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      115. Srivastava D. Building a heart: implications for congenital heart disease. J Nucl Cardiol. 2003 Jan-Feb; 10(1):63-70.
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      116. Srivastava D. Handbook of Cell Signaling (Bradshaw RA, Dennis EA, Eds). Signaling Pathways Involved in Cardiogenesis. 2003; 3:463–470.
      117. Villanueva MP, Aiyer AR, Muller S, Pletcher MT, Liu X, Emanuel B, Srivastava D, Reeves RH. Genetic and comparative mapping of genes dysregulated in mouse hearts lacking the Hand2 transcription factor gene. Genomics. 2002 Dec; 80(6):593-600.
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      118. Abe M, Tamamura Y, Yamagishi H, Maeda T, Kato J, Tabata MJ, Srivastava D, Wakisaka S, Kurisu K. Tooth-type specific expression of dHAND/Hand2: possible involvement in murine lower incisor morphogenesis. Cell Tissue Res. 2002 Nov; 310(2):201-12.
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      119. Gottlieb PD, Pierce SA, Sims RJ, Yamagishi H, Weihe EK, Harriss JV, Maika SD, Kuziel WA, King HL, Olson EN, Nakagawa O, Srivastava D. Bop encodes a muscle-restricted protein containing MYND and SET domains and is essential for cardiac differentiation and morphogenesis. Nat Genet. 2002 May; 31(1):25-32.
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      120. Srivastava D, Gottlieb PD, Olson EN. Molecular mechanisms of ventricular hypoplasia. Cold Spring Harb Symp Quant Biol. 2002; 67:121-5.
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      121. Srivastava D. Neonatal Cardiology (Artman M, Mahony L, Teitel DF, Eds). Molecular and morphogenetic cardiac embryology: Implications for congenital heart disease. 2002; 1–15.
      122. Yamagishi H, Yamagishi C, Nakagawa O, Harvey RP, Olson EN, Srivastava D. The combinatorial activities of Nkx2.5 and dHAND are essential for cardiac ventricle formation. Dev Biol. 2001 Nov 15; 239(2):190-203.
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      123. Kunte A, Ivey K, Yamagishi C, Garg V, Yamagishi H, Srivastava D. A common cis-acting sequence in the DiGeorge critical region regulates bi-directional transcription of UFD1L and CDC45L. Mech Dev. 2001 Oct; 108(1-2):81-92.
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      124. Natarajan A, Yamagishi H, Ahmad F, Li D, Roberts R, Matsuoka R, Hill S, Srivastava D. Human eHAND, but not dHAND, is down-regulated in cardiomyopathies. J Mol Cell Cardiol. 2001 Sep; 33(9):1607-14.
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      125. Garg V, Yamagishi C, Hu T, Kathiriya IS, Yamagishi H, Srivastava D. Tbx1, a DiGeorge syndrome candidate gene, is regulated by sonic hedgehog during pharyngeal arch development. Dev Biol. 2001 Jul 1; 235(1):62-73.
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      126. Liu ZP, Nakagawa O, Nakagawa M, Yanagisawa H, Passier R, Richardson JA, Srivastava D, Olson EN. CHAMP, a novel cardiac-specific helicase regulated by MEF2C. Dev Biol. 2001 Jun 15; 234(2):497-509.
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      127. Srivastava D. Genetic assembly of the heart: implications for congenital heart disease. Annu Rev Physiol. 2001; 63:451-69.
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      128. Srivastava D, Baldwin HS. Moss and Adams' Heart Disease in Infants, Children, and Adolescents (Allen HD, Gutsgell HP, Clark EB, Driscoll DJ, Eds). Molecular determinants of cardiac development. 2001.
      129. Olson EN, Srivastava D. Encyclopedia of Molecular Medicine (Creighton TE and Kazazian HH, Eds). HAND transcription factors. 2001.
      130. Nakagawa O, McFadden DG, Nakagawa M, Yanagisawa H, Hu T, Srivastava D, Olson EN. Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling. Proc Natl Acad Sci U S A. 2000 Dec 5; 97(25):13655-60.
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      131. McFadden DG, Charité J, Richardson JA, Srivastava D, Firulli AB, Olson EN. A GATA-dependent right ventricular enhancer controls dHAND transcription in the developing heart. Development. 2000 Dec; 127(24):5331-41.
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      132. Fisher SA, Langille BL, Srivastava D. Apoptosis during cardiovascular development. Circ Res. 2000 Nov 10; 87(10):856-64.
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      133. Srivastava D, Olson EN. A genetic blueprint for cardiac development. Nature. 2000 Sep 14; 407(6801):221-6.
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      134. Angelo S, Lohr J, Lee KH, Ticho BS, Breitbart RE, Hill S, Yost HJ, Srivastava D. Conservation of sequence and expression of Xenopus and zebrafish dHAND during cardiac, branchial arch and lateral mesoderm development. Mech Dev. 2000 Jul; 95(1-2):231-7.
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      135. Srivastava D. Congenital heart defects: trapping the genetic culprits. Circ Res. 2000 May 12; 86(9):917-8.
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      136. Fernandez-Teran M, Piedra ME, Kathiriya IS, Srivastava D, Rodriguez-Rey JC, Ros MA. Role of dHAND in the anterior-posterior polarization of the limb bud: implications for the Sonic hedgehog pathway. Development. 2000 May; 127(10):2133-42.
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      137. Yamagishi H, Olson EN, Srivastava D. The basic helix-loop-helix transcription factor, dHAND, is required for vascular development. J Clin Invest. 2000 Feb; 105(3):261-70.
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      138. Srivastava D. Etiology and Morphogenesis of Congenital Heart Disease (Takao A, Nakazawa M, Clark EB, Eds). Understanding CHD through dissection of segmental cardiac molecular pathways. 2000; 205–210.
      139. Yamagishi H, Srivastava D. Etiology and Morphogenesis of Congenital Heart Disease (Clark EB, Nakazawa M, Takao A, Eds). Role of the bHLH transcription factor, dHAND, in cranial/cardiac neural crest development. 2000; 325–328.
      140. Kathiriya IS, Srivastava D. Left-right asymmetry and cardiac looping: implications for cardiac development and congenital heart disease. Am J Med Genet. 2000; 97(4):271-9.
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      141. Srivastava D. DiGeorge syndrome: an enigma in mice and men. Mol Med Today. 2000 Jan; 6(1):13-4.
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      142. Nakagawa O, Nakagawa M, Richardson JA, Olson EN, Srivastava D. HRT1, HRT2, and HRT3: a new subclass of bHLH transcription factors marking specific cardiac, somitic, and pharyngeal arch segments. Dev Biol. 1999 Dec 1; 216(1):72-84.
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      143. Srivastava D, Yamagishi H. Reply: role of the dHAND-UFD1L pathway Trends Genet. 1999 Jul; 15(7):253-4.
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      144. Srivastava D. Developmental and genetic aspects of congenital heart disease. Curr Opin Cardiol. 1999 May; 14(3):263-8.
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      145. Yamagishi H, Garg V, Matsuoka R, Thomas T, Srivastava D. A molecular pathway revealing a genetic basis for human cardiac and craniofacial defects. Science. 1999 Feb 19; 283(5405):1158-61.
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      146. Srivastava D. Heart Development (Rosenthal N and Harvey R, Eds). Segmental regulation of cardiac development by the basic helix-loop-helix transcription factors dHAND and eHAND. 1999; 143–155.
      147. Srivastava D. HAND proteins: molecular mediators of cardiac development and congenital heart disease. Trends Cardiovasc Med. 1999 Jan-Feb; 9(1-2):11-8.
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      148. Thomas T, Kurihara H, Yamagishi H, Kurihara Y, Yazaki Y, Olson EN, Srivastava D. A signaling cascade involving endothelin-1, dHAND and msx1 regulates development of neural-crest-derived branchial arch mesenchyme. Development. 1998 Aug; 125(16):3005-14.
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      149. Thomas T, Yamagishi H, Overbeek PA, Olson EN, Srivastava D. The bHLH factors, dHAND and eHAND, specify pulmonary and systemic cardiac ventricles independent of left-right sidedness. Dev Biol. 1998 Apr 15; 196(2):228-36.
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      150. Firulli AB, McFadden DG, Lin Q, Srivastava D, Olson EN. Heart and extra-embryonic mesodermal defects in mouse embryos lacking the bHLH transcription factor Hand1. Nat Genet. 1998 Mar; 18(3):266-70.
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      151. Srivastava D. Left, right ... which way to turn? Nat Genet. 1997 Nov; 17(3):252-4.
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      152. Srivastava D, Olson EN. Knowing in your heart what's right. Trends Cell Biol. 1997 Nov; 7(11):447-53.
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      153. Srivastava D, Thomas T, Lin Q, Kirby ML, Brown D, Olson EN. Regulation of cardiac mesodermal and neural crest development by the bHLH transcription factor, dHAND. Nat Genet. 1997 Jun; 16(2):154-60.
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      154. Srivastava D. Genetic Control of Heart Development (Harvey RP, Olson EN, Schulz RA, Altman JS, Eds). The bHLH proteins, dHAND and eHAND in cardiac development. 1997.
      155. Lin Q, Srivastava D, Olson EN. A transcriptional pathway for cardiac development. Cold Spring Harb Symp Quant Biol. 1997; 62:405-11.
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      156. Srivastava D, Olson EN. Neurotrophin-3 knocks heart off Trk. Nat Med. 1996 Oct; 2(10):1069-71.
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      157. Olson EN, Srivastava D. Molecular pathways controlling heart development. Science. 1996 May 3; 272(5262):671-6.
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      158. Srivastava D, Cserjesi P, Olson EN. A subclass of bHLH proteins required for cardiac morphogenesis. Science. 1995 Dec 22; 270(5244):1995-9.
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      159. Srivastava D, Preminger T, Lock JE, Mandell V, Keane JF, Mayer JE, Kozakewich H, Spevak PJ. Hepatic venous blood and the development of pulmonary arteriovenous malformations in congenital heart disease. Circulation. 1995 Sep 1; 92(5):1217-22.
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      160. Srivastava D, Thompson EB. Two glucocorticoid binding sites on the human glucocorticoid receptor. Endocrinology. 1990 Oct; 127(4):1770-8.
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      161. Thompson EB, Srivastava D, Johnson BH. Interactions of the phenylpyrazolo steroid cortivazol with glucocorticoid receptors in steroid-sensitive and -resistant human leukemic cells. Cancer Res. 1989 Apr 15; 49(8 Suppl):2253s-2258s.
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