Aaron Scheffler, PhD, MS

Title(s)Assistant Professor, Epidemiology & Biostatistics
SchoolSchool of Medicine
Address550 16th. Street, #2544
San Francisco CA 94158
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ORCID ORCID Icon0000-0003-3212-748X Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of California, Los AngelesPhD2019Biostatistics
    University of California, Los AngelesMS2015Biostatistics
    Columbia UniversityBA2011Biochemistry

    Collapse Overview 
    Collapse Overview
    My research centers on the statistical challenges posed by highly structured data collected in an increasing number of applications ranging from imaging to wearable technologies. Frequently, the observed data are discrete samples of an underlying functional process which exhibits complex dependencies that are difficult to capture using traditional statistical models. A central theme in my research is to provide computationally efficient methods for these rich data structures that maintain information along each dimension while simultaneously providing interpretable components and inferences. In addition, I apply techniques from statistics and machine learning including mixed effects models, gradient boosting, and tree based methods, to assist collaborators in psychiatry, neurology, oncology, and HIV/AIDS research.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Maternal treatment with selective serotonin reuptake inhibitors during pregnancy and delayed neonatal adaptation: a population-based cohort study. Arch Dis Child Fetal Neonatal Ed. 2023 Nov 29. Cornet MC, Wu YW, Forquer H, Avalos LA, Sriram A, Scheffler AW, Newman TB, Kuzniewicz MW. PMID: 38071585.
      View in: PubMed   Mentions:    Fields:    
    2. Bayesian adaptive design for covariate-adaptive historical control information borrowing. Stat Med. 2023 12 20; 42(29):5338-5352. Jin H, Kim MO, Scheffler A, Jiang F. PMID: 37750361; PMCID: PMC10919261.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Quantitative analysis of MGMT promoter methylation in glioblastoma suggests nonlinear prognostic effect. Neurooncol Adv. 2023 Jan-Dec; 5(1):vdad115. Gibson D, Ravi A, Rodriguez E, Chang S, Oberheim Bush N, Taylor J, Clarke J, Solomon D, Scheffler A, Witte J, Lambing H, Okada H, Berger M, Chehab F, Butowski NA. PMID: 37899778; PMCID: PMC10611422.
      View in: PubMed   Mentions: 2  
    4. Correlating Quantitative MRI-based Apparent Diffusion Coefficient Metrics with 24-month Neurodevelopmental Outcomes in Neonates from the HEAL Trial. Radiology. 2023 09; 308(3):e223262. Calabrese E, Wu Y, Scheffler AW, Wisnowski JL, McKinstry RC, Mathur A, Glass HC, Comstock BA, Heagerty PJ, Gillon S, Juul SE, Hess CP, Li Y. PMID: 37698478; PMCID: PMC10546287.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. Perinatal Hypoxic-Ischemic Encephalopathy: Incidence Over Time Within a Modern US Birth Cohort. Pediatr Neurol. 2023 Dec; 149:145-150. Cornet MC, Kuzniewicz M, Scheffler A, Forquer H, Hamilton E, Newman TB, Wu YW. PMID: 37883841; PMCID: PMC10842130.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    6. CAPER: patient preferences to inform nonsurgical treatment of chronic low back pain: a discrete-choice experiment. Pain Med. 2023 08 01; 24(8):963-973. Wilson L, Zheng P, Ionova Y, Denham A, Yoo C, Ma Y, Greco CM, Hanmer J, Williams DA, Hassett AL, Scheffler AW, Valone F, Mehling W, Berven S, Lotz J, O'Neill C. PMID: 36975607.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    7. Neonatal brain MRI and short-term outcomes after acute provoked seizures. J Perinatol. 2023 11; 43(11):1392-1397. Li Y, Scheffler A, Barkovich AJ, Chang T, Chu CJ, Massey SL, Abend NS, Lemmon ME, Thomas C, Numis A, Franck LS, Rogers E, Callen A, McCulloch CE, Shellhaas RA, Glass HC. PMID: 37454174; PMCID: PMC10615741.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    8. Network anatomy in logopenic variant of primary progressive aphasia. Hum Brain Mapp. 2023 08 01; 44(11):4390-4406. Mandelli ML, Lorca-Puls DL, Lukic S, Montembeault M, Gajardo-Vidal A, Licata A, Scheffler A, Battistella G, Grasso SM, Bogley R, Ratnasiri BM, La Joie R, Mundada NS, Europa E, Rabinovici G, Miller BL, De Leon J, Henry ML, Miller Z, Gorno-Tempini ML. PMID: 37306089; PMCID: PMC10318204.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    9. Efficacy of alcohol reduction interventions among people with HIV as evaluated by self-report and a phosphatidylethanol (PEth) outcome: protocol for a systematic review and individual participant data meta-analysis. BMJ Open. 2023 06 06; 13(6):e070713. Kane JC, Allen I, Fatch R, Scheffler A, Emenyonu N, Puryear SB, Chirayil P, So-Armah K, Kahler CW, Magidson JF, Conroy AA, Edelman EJ, Woolf-King S, Parry C, Kiene SM, Chamie G, Adong J, Go VF, Cook RL, Muyindike W, Morojele N, Blokhina E, Krupitsky E, Fiellin DA, Hahn JA. PMID: 37280036; PMCID: PMC10254608.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    10. A novel thiol-saccharide mucolytic for the treatment of muco-obstructive lung diseases. Eur Respir J. 2023 05; 61(5). Addante A, Raymond W, Gitlin I, Charbit A, Orain X, Scheffler AW, Kuppe A, Duerr J, Daniltchenko M, Drescher M, Graeber SY, Healy AM, Oscarson S, Fahy JV, Mall MA. PMID: 37080569; PMCID: PMC10209473.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    11. Network anatomy in logopenic variant of primary progressive aphasia. medRxiv. 2023 May 16. Mandelli ML, Lorca-Puls DL, Lukic S, Montembeault M, Gajardo-Vidal A, Licata A, Scheffler A, Battistella G, Grasso SM, Bogley R, Ratnasiri BM, La Joie R, Mundada NS, Europa E, Rabinovici G, Miller BL, De Leon J, Henry ML, Miller Z, Gorno-Tempini ML. PMID: 37292690; PMCID: PMC10246009.
      View in: PubMed   Mentions:
    12. Modeling longitudinal trends in event-related potentials. . 2023 Jan 1. Senturk SD, Scheffler SA. .
      View in: Publisher Site   Mentions:
    13. Point-of-care motion capture and biomechanical assessment improve clinical utility of dynamic balance testing for lower extremity osteoarthritis. PLOS Digit Health. 2022 Jul; 1(7):e0000068. Halvorson RT, Castillo FT, Ahamed F, Khattab K, Scheffler A, Matthew RP, Lotz J, Vail TP, Feeley BT, Bailey JF. PMID: 36812556; PMCID: PMC9931224.
      View in: PubMed   Mentions:
    14. Mild hypoxic-ischemic encephalopathy (HIE): timing and pattern of MRI brain injury. Pediatr Res. 2022 12; 92(6):1731-1736. Li Y, Wisnowski JL, Chalak L, Mathur AM, McKinstry RC, Licona G, Mayock DE, Chang T, Van Meurs KP, Wu TW, Ahmad KA, Cornet MC, Rao R, Scheffler A, Wu YW. PMID: 35354930; PMCID: PMC9771796.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    15. 5-Year Revision Rates After Elective Multilevel Lumbar/Thoracolumbar Instrumented Fusions in Older Patients: An Analysis of State Databases. J Am Acad Orthop Surg. 2022 May 15; 30(10):476-483. Cummins DD, Callahan M, Scheffler A, Theologis AA. PMID: 35196291.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    16. Germline biomarkers predict toxicity to anti-PD1/PDL1 checkpoint therapy. J Immunother Cancer. 2022 02; 10(2). Weidhaas J, Marco N, Scheffler AW, Kalbasi A, Wilenius K, Rietdorf E, Gill J, Heilig M, Desler C, Chin RK, Kaprealian T, McCloskey S, Raldow A, Raja NP, Kesari S, Carrillo J, Drakaki A, Scholz M, Telesca D. PMID: 35115362; PMCID: PMC8804679.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    17. Covariate-adjusted hybrid principal components analysis for region-referenced functional EEG data. Stat Interface. 2022; 15(2):209-223. Scheffler AW, Dickinson A, DiStefano C, Jeste S, Sentürk D. PMID: 35664510; PMCID: PMC9165697.
      View in: PubMed   Mentions: 1  
    18. Persistence, Magnitude, and Patterns of Postacute Symptoms and Quality of Life Following Onset of SARS-CoV-2 Infection: Cohort Description and Approaches for Measurement. Open Forum Infect Dis. 2022 Feb; 9(2):ofab640. Peluso MJ, Kelly JD, Lu S, Goldberg SA, Davidson MC, Mathur S, Durstenfeld MS, Spinelli MA, Hoh R, Tai V, Fehrman EA, Torres L, Hernandez Y, Williams MC, Arreguin MI, Ngo LH, Deswal M, Munter SE, Martinez EO, Anglin KA, Romero MD, Tavs J, Rugart PR, Chen JY, Sans HM, Murray VW, Ellis PK, Donohue KC, Massachi JA, Weiss JO, Mehdi I, Pineda-Ramirez J, Tang AF, Wenger MA, Assenzio MT, Yuan Y, Krone MR, Rutishauser RL, Rodriguez-Barraquer I, Greenhouse B, Sauceda JA, Gandhi M, Scheffler AW, Hsue PY, Henrich TJ, Deeks SG, Martin JN. PMID: 35106317; PMCID: PMC8755302.
      View in: PubMed   Mentions: 38  
    19. BIOM-07. QUANTITATIVE MGMT PROMOTER METHYLATION INDEX INDICATES A NON-LINEAR PROGNOSTIC EFFECT IN GLIOBLASTOMA, SUGGESTING THAT USE OF OPTIMAL CUTOFF POINTS MAY BE CLINICALLY DISADVANTAGEOUS. Neuro-Oncology. 2021 Nov 12; 23(Supplement_6):vi11-vi11. Gibson GD, Ravi RA, Almaraz AE, Chang CS, Oberheim-Bush ON, Taylor TJ, Clarke CJ, Solomon SD, Scheffler SA, Witte WJ, Lambing LH, Berger BM, Okada OH, Chehab CF, Butowski BN. .
      View in: Publisher Site   Mentions:
    20. Biomechanical changes in the lumbar spine following spaceflight and factors associated with postspaceflight disc herniation. Spine J. 2022 02; 22(2):197-206. Bailey JF, Nyayapati P, Johnson GTA, Dziesinski L, Scheffler AW, Crawford R, Scheuring R, O'Neill CW, Chang D, Hargens AR, Lotz JC. PMID: 34343665.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    21. Early Magnetic Resonance Imaging Predicts 30-Month Outcomes after Therapeutic Hypothermia for Neonatal Encephalopathy. J Pediatr. 2021 Nov; 238:94-101.e1. Bach AM, Fang AY, Bonifacio S, Rogers EE, Scheffler A, Partridge JC, Xu D, Barkovich AJ, Ferriero DM, Glass HC, Gano D. PMID: 34237346.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    22. NGMA-6. Quantitative MGMT Promoter Methylation Index Indicates Non-Linear, Prognostic Effect in Glioblastoma. Neuro-Oncology Advances. 2021 Jul 5; 3(Supplement_2):ii5-ii5. Gibson GD, Ravi RA, Rodriguez RE, Chang CS, Bush BN, Taylor TJ, Clarke CJ, Solomon SD, Scheffler SA, Witte WJ, Okada OH, Berger BM, Chehab CF, Butowski BN. .
      View in: Publisher Site   Mentions:
    23. Cortically constrained shape recognition: Automated white matter tract segmentation validated in the pediatric brain. J Neuroimaging. 2021 07; 31(4):758-772. Jordan KM, Lauricella M, Licata AE, Sacco S, Asteggiano C, Wang C, Sudarsan SP, Watson C, Scheffler AW, Battistella G, Miller ZA, Gorno-Tempini ML, Caverzasi E, Mandelli ML. PMID: 33878229.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    24. Functional connectivity during language processing in 3-month-old infants at familial risk for autism spectrum disorder. Eur J Neurosci. 2021 03; 53(5):1621-1637. Tran XA, McDonald N, Dickinson A, Scheffler A, Frohlich J, Marin A, Kure Liu C, Nosco E, Sentürk D, Dapretto M, Spurling Jeste S. PMID: 33043498.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    25. A pilot randomized controlled trial (RCT) of daily versus weekly interactive voice response calls to support adherence among antiretroviral treatment patients in India. Mhealth. 2020; 6:35. Swendeman D, Fehrenbacher AE, Roy S, Ray P, Sumstine S, Scheffler A, Das R, Jana S. PMID: 33437832; PMCID: PMC7793015.
      View in: PubMed   Mentions: 3  
    26. Properties of beta oscillations in Dup15q syndrome. J Neurodev Disord. 2020 08 13; 12(1):22. Saravanapandian V, Frohlich J, Hipp JF, Hyde C, Scheffler AW, Golshani P, Cook EH, Reiter LT, Senturk D, Jeste SS. PMID: 32791992; PMCID: PMC7425173.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    27. Day-to-Day Test-Retest Reliability of EEG Profiles in Children With Autism Spectrum Disorder and Typical Development. Front Integr Neurosci. 2020; 14:21. Levin AR, Naples AJ, Scheffler AW, Webb SJ, Shic F, Sugar CA, Murias M, Bernier RA, Chawarska K, Dawson G, Faja S, Jeste S, Nelson CA, McPartland JC, Sentürk D. PMID: 32425762; PMCID: PMC7204836.
      View in: PubMed   Mentions: 16  
    28. Developmental Trajectories of Infants With Multiplex Family Risk for Autism: A Baby Siblings Research Consortium Study. JAMA Neurol. 2020 01 01; 77(1):73-81. McDonald NM, Senturk D, Scheffler A, Brian JA, Carver LJ, Charman T, Chawarska K, Curtin S, Hertz-Piccioto I, Jones EJH, Klin A, Landa R, Messinger DS, Ozonoff S, Stone WL, Tager-Flusberg H, Webb SJ, Young G, Zwaigenbaum L, Jeste SS. PMID: 31589284; PMCID: PMC6784852.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    29. Hybrid principal components analysis for region-referenced longitudinal functional EEG data. Biostatistics. 2020 01 01; 21(1):139-157. Scheffler A, Telesca D, Li Q, Sugar CA, Distefano C, Jeste S, Sentürk D. PMID: 30084925; PMCID: PMC6920529.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    30. Covariate-Adjusted Hybrid Principal Components Analysis. . 2020 Jan 1; 1239:391-404. Scheffler SA, Dickinson DA, DiStefano DC, Jeste JS, Sentürk SD. .
      View in: Publisher Site   Mentions:
    31. Covariate-adjusted region-referenced generalized functional linear model for EEG data. Stat Med. 2019 12 30; 38(30):5587-5602. Scheffler AW, Telesca D, Sugar CA, Jeste S, Dickinson A, DiStefano C, Sentürk D. PMID: 31659786; PMCID: PMC6891124.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    32. A germline microRNA-based biomarker signature of immune-associated toxicity to anti-PD1/PDL1 therapy. Journal of Clinical Oncology. 2019 Mar 10; 37(8_suppl):96-96. Weidhaas WJ, Scheffler SA, Salzman SD, Kalbasi KA, Wilenius WK, Rietdorf RE, Heilig HM, Pitka PM, Desler DC, Ruan RD, Ribas RA, Drakaki DA, Scholz SM, Telesca TD. .
      View in: Publisher Site   Mentions:
    33. Interhemispheric alpha-band hypoconnectivity in children with autism spectrum disorder. Behav Brain Res. 2018 08 01; 348:227-234. Dickinson A, DiStefano C, Lin YY, Scheffler AW, Senturk D, Jeste SS. PMID: 29689375; PMCID: PMC5993636.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    34. Maternal patterns of antenatal and postnatal depressed mood and the impact on child health at 3-years postpartum. J Consult Clin Psychol. 2018 03; 86(3):218-230. Rotheram-Fuller EJ, Tomlinson M, Scheffler A, Weichle TW, Hayati Rezvan P, Comulada WS, Rotheram-Borus MJ. PMID: 29504791; PMCID: PMC5842813.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    35. A microRNA-based signature predicting immune-related toxicity (iRAEs) to pembrolizumab in prostate cancer patients. Journal of Clinical Oncology. 2018 Feb 20; 36(6_suppl):269-269. Weidhaas WJ, Wilenius WK, Scheffler SA, Higa HJ, Telesca TD, Scholz SM. .
      View in: Publisher Site   Mentions:
    36. Antenatal depressed mood and child cognitive and physical growth at 18-months in South Africa: a cluster randomised controlled trial of home visiting by community health workers. Epidemiol Psychiatr Sci. 2018 Dec; 27(6):601-610. Tomlinson M, Rotheram-Borus MJ, Scheffler A, le Roux I. PMID: 28606206; PMCID: PMC6998999.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    37. Adjustment of a Population of South African Children of Mothers Living With/and Without HIV Through Three Years Post-Birth. AIDS Behav. 2017 Jun; 21(6):1601-1610. Rotheram-Borus MJ, Tomlinson M, Scheffler A, Harris DM, Nelson S. PMID: 27260178; PMCID: PMC5136343.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansPHPublic Health
    38. A multi-dimensional functional principal components analysis of EEG data. Biometrics. 2017 09; 73(3):999-1009. Hasenstab K, Scheffler A, Telesca D, Sugar CA, Jeste S, DiStefano C, Sentürk D. PMID: 28072468; PMCID: PMC5517364.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    39. Thirty-Six-Month Outcomes of a Generalist Paraprofessional Perinatal Home Visiting Intervention in South Africa on Maternal Health and Child Health and Development. Prev Sci. 2016 11; 17(8):937-948. Tomlinson M, Rotheram-Borus MJ, le Roux IM, Youssef M, Nelson SH, Scheffler A, Weiss RE, O'Connor M, Worthman CM. PMID: 27438294; PMCID: PMC5111552.
      View in: PubMed   Mentions: 32     Fields:    Translation:Humans
    40. Drug use and emotional distress differentiate unstably- versus stably-housed adults living with HIV who engage in unprotected sex. J Health Psychol. 2017 03; 22(3):302-313. Arnold EM, Desmond KA, Rotheram-Borus MJ, Scheffler A, Comulada WS, Johnson MO, Kelly JA, Healthy Living Project Group. PMID: 26359286; PMCID: PMC4785098.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    41. Re-engagement in HIV care among mothers living with HIV in South Africa over 36 months post-birth. AIDS. 2015 Nov; 29(17):2361-2. Rotheram-Borus MJ, Tomlinson M, Scheffler A, Le Roux IM. PMID: 26258526; PMCID: PMC4641027.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    42. Smartphone self-monitoring to support self-management among people living with HIV: perceived benefits and theory of change from a mixed-methods randomized pilot study. J Acquir Immune Defic Syndr. 2015 May 01; 69 Suppl 1:S80-91. Swendeman D, Ramanathan N, Baetscher L, Medich M, Scheffler A, Comulada WS, Estrin D. PMID: 25867783; PMCID: PMC4485442.
      View in: PubMed   Mentions: 42     Fields:    Translation:Humans
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