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Aashish Manglik, PhD, MD

TitleAssistant Professor
SchoolUCSF School of Pharmacy
DepartmentPharmaceutical Chemistry
Address1700 4th St
San Francisco CA 94158
Phone415-502-3744
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    Collapse Biography 
    Collapse Education and Training
    Washington University in St. Louis, St. Louis, MOB.A.05/2008Chemistry and Biology
    Stanford University, Stanford, CAPh.D.02/2014Biophysics
    Stanford University, Stanford, CAM.D.05/2016
    Collapse Awards and Honors
    Washington University in St. Louis2008Spector Award
    Scientific American201330 under 30
    National Institutes of Health2016  - 2021Director's Early Independence Award
    International Narcotics Research Conference2017Young Investigator Award

    Collapse Overview 

    Collapse ORNG Applications 
    Collapse Websites
    Collapse In The News
    Collapse Twitter
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Manglik A, Kobilka BK, Steyaert J. Nanobodies to Study G Protein-Coupled Receptor Structure and Function. Annu Rev Pharmacol Toxicol. 2017 Jan 06; 57:19-37. PMID: 27959623.
      View in: PubMed
    2. Manglik A, Lin H, Aryal DK, McCorvy JD, Dengler D, Corder G, Levit A, Kling RC, Bernat V, Hübner H, Huang XP, Sassano MF, Giguère PM, Löber S, Scherrer G, Kobilka BK, Gmeiner P, Roth BL, Shoichet BK, et al. Structure-based discovery of opioid analgesics with reduced side effects. Nature. 2016 Aug 17; 537(7619):185-190. PMID: 27533032.
      View in: PubMed
    3. Staus DP, Strachan RT, Manglik A, Pani B, Kahsai AW, Kim TH, Wingler LM, Ahn S, Chatterjee A, Masoudi A, Kruse AC, Pardon E, Steyaert J, Weis WI, Prosser RS, Kobilka BK, Costa T, Lefkowitz RJ. Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation. Nature. 2016 07 21; 535(7612):448-52. PMID: 27409812; PMCID: PMC4961583 [Available on 01/21/17].
    4. DeVree BT, Mahoney JP, Vélez-Ruiz GA, Rasmussen SG, Kuszak AJ, Edwald E, Fung JJ, Manglik A, Masureel M, Du Y, Matt RA, Pardon E, Steyaert J, Kobilka BK, Sunahara RK. Allosteric coupling from G protein to the agonist-binding pocket in GPCRs. Nature. 2016 07 07; 535(7610):182-6. PMID: 27362234.
      View in: PubMed
    5. Schmidt HR, Zheng S, Gurpinar E, Koehl A, Manglik A, Kruse AC. Crystal structure of the human σ1 receptor. Nature. 2016 Apr 28; 532(7600):527-30. PMID: 27042935.
      View in: PubMed
    6. Baxter EL, Aguila L, Alonso-Mori R, Barnes CO, Bonagura CA, Brehmer W, Brunger AT, Calero G, Caradoc-Davies TT, Chatterjee R, Degrado WF, Fraser JS, Ibrahim M, Kern J, Kobilka BK, Kruse AC, Larsson KM, Lemke HT, Lyubimov AY, Manglik A, McPhillips SE, Norgren E, Pang SS, Soltis SM, Song J, Thomaston J, Tsai Y, Weis WI, Woldeyes RA, Yachandra V, Yano J, Zouni A, Cohen AE. High-density grids for efficient data collection from multiple crystals. Acta Crystallogr D Struct Biol. 2016 Jan; 72(Pt 1):2-11. PMID: 26894529.
      View in: PubMed
    7. Maute RL, Gordon SR, Mayer AT, McCracken MN, Natarajan A, Ring NG, Kimura R, Tsai JM, Manglik A, Kruse AC, Gambhir SS, Weissman IL, Ring AM. Engineering high-affinity PD-1 variants for optimized immunotherapy and immuno-PET imaging. Proc Natl Acad Sci U S A. 2015 Nov 24; 112(47):E6506-14. PMID: 26604307; PMCID: PMC4664306.
    8. Huang W, Manglik A, Venkatakrishnan AJ, Laeremans T, Feinberg EN, Sanborn AL, Kato HE, Livingston KE, Thorsen TS, Kling RC, Granier S, Gmeiner P, Husbands SM, Traynor JR, Weis WI, Steyaert J, Dror RO, Kobilka BK. Structural insights into µ-opioid receptor activation. Nature. 2015 Aug 20; 524(7565):315-21. PMID: 26245379; PMCID: PMC4639397.
    9. Sounier R, Mas C, Steyaert J, Laeremans T, Manglik A, Huang W, Kobilka BK, Déméné H, Granier S. Propagation of conformational changes during μ-opioid receptor activation. Nature. 2015 Aug 20; 524(7565):375-8. PMID: 26245377; PMCID: PMC4820006.
    10. Dror RO, Mildorf TJ, Hilger D, Manglik A, Borhani DW, Arlow DH, Philippsen A, Villanueva N, Yang Z, Lerch MT, Hubbell WL, Kobilka BK, Sunahara RK, Shaw DE. SIGNAL TRANSDUCTION. Structural basis for nucleotide exchange in heterotrimeric G proteins. Science. 2015 Jun 19; 348(6241):1361-5. PMID: 26089515; PMCID: PMC4968074.
    11. Manglik A, Kim TH, Masureel M, Altenbach C, Yang Z, Hilger D, Lerch MT, Kobilka TS, Thian FS, Hubbell WL, Prosser RS, Kobilka BK. Structural Insights into the Dynamic Process of β2-Adrenergic Receptor Signaling. Cell. 2015 May 21; 161(5):1101-11. PMID: 25981665; PMCID: PMC4441853.
    12. Ye L, Larda ST, Frank Li YF, Manglik A, Prosser RS. A comparison of chemical shift sensitivity of trifluoromethyl tags: optimizing resolution in ¹⁹F NMR studies of proteins. J Biomol NMR. 2015 May; 62(1):97-103. PMID: 25813845.
      View in: PubMed
    13. Li L, Homan KT, Vishnivetskiy SA, Manglik A, Tesmer JJ, Gurevich VV, Gurevich EV. G Protein-coupled Receptor Kinases of the GRK4 Protein Subfamily Phosphorylate Inactive G Protein-coupled Receptors (GPCRs). J Biol Chem. 2015 Apr 24; 290(17):10775-90. PMID: 25770216; PMCID: PMC4409243.
    14. Cohen AE, Soltis SM, González A, Aguila L, Alonso-Mori R, Barnes CO, Baxter EL, Brehmer W, Brewster AS, Brunger AT, Calero G, Chang JF, Chollet M, Ehrensberger P, Eriksson TL, Feng Y, Hattne J, Hedman B, Hollenbeck M, Holton JM, Keable S, Kobilka BK, Kovaleva EG, Kruse AC, Lemke HT, Lin G, Lyubimov AY, Manglik A, Mathews II, McPhillips SE, Nelson S, Peters JW, Sauter NK, Smith CA, Song J, Stevenson HP, Tsai Y, Uervirojnangkoorn M, Vinetsky V, Wakatsuki S, Weis WI, Zadvornyy OA, Zeldin OB, Zhu D, Hodgson KO. Goniometer-based femtosecond crystallography with X-ray free electron lasers. Proc Natl Acad Sci U S A. 2014 Dec 2; 111(48):17122-7. PMID: 25362050; PMCID: PMC4260607.
    15. Weichert D, Kruse AC, Manglik A, Hiller C, Zhang C, Hübner H, Kobilka BK, Gmeiner P. Covalent agonists for studying G protein-coupled receptor activation. Proc Natl Acad Sci U S A. 2014 Jul 22; 111(29):10744-8. PMID: 25006259; PMCID: PMC4115510.
    16. Manglik A, Kobilka B. The role of protein dynamics in GPCR function: insights from the β2AR and rhodopsin. Curr Opin Cell Biol. 2014 Apr; 27:136-43. PMID: 24534489; PMCID: PMC3986065.
    17. Kruse AC, Ring AM, Manglik A, Hu J, Hu K, Eitel K, Hübner H, Pardon E, Valant C, Sexton PM, Christopoulos A, Felder CC, Gmeiner P, Steyaert J, Weis WI, Garcia KC, Wess J, Kobilka BK. Activation and allosteric modulation of a muscarinic acetylcholine receptor. Nature. 2013 Dec 05; 504(7478):101-6. PMID: 24256733; PMCID: PMC4020789.
    18. Kruse AC, Manglik A, Kobilka BK, Weis WI. Applications of molecular replacement to G protein-coupled receptors. Acta Crystallogr D Biol Crystallogr. 2013 Nov; 69(Pt 11):2287-92. PMID: 24189241; PMCID: PMC3817703.
    19. Ring AM, Manglik A, Kruse AC, Enos MD, Weis WI, Garcia KC, Kobilka BK. Adrenaline-activated structure of β2-adrenoceptor stabilized by an engineered nanobody. Nature. 2013 Oct 24; 502(7472):575-579. PMID: 24056936; PMCID: PMC3822040.
    20. Kim TH, Chung KY, Manglik A, Hansen AL, Dror RO, Mildorf TJ, Shaw DE, Kobilka BK, Prosser RS. The role of ligands on the equilibria between functional states of a G protein-coupled receptor. J Am Chem Soc. 2013 Jun 26; 135(25):9465-74. PMID: 23721409; PMCID: PMC3763947.
    21. Shukla AK, Manglik A, Kruse AC, Xiao K, Reis RI, Tseng WC, Staus DP, Hilger D, Uysal S, Huang LY, Paduch M, Tripathi-Shukla P, Koide A, Koide S, Weis WI, Kossiakoff AA, Kobilka BK, Lefkowitz RJ. Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide. Nature. 2013 May 02; 497(7447):137-41. PMID: 23604254; PMCID: PMC3654799.
    22. Nygaard R, Zou Y, Dror RO, Mildorf TJ, Arlow DH, Manglik A, Pan AC, Liu CW, Fung JJ, Bokoch MP, Thian FS, Kobilka TS, Shaw DE, Mueller L, Prosser RS, Kobilka BK. The dynamic process of ß(2)-adrenergic receptor activation. Cell. 2013 Jan 31; 152(3):532-42. PMID: 23374348; PMCID: PMC3586676.
    23. Chung KY, Kim TH, Manglik A, Alvares R, Kobilka BK, Prosser RS. Role of detergents in conformational exchange of a G protein-coupled receptor. J Biol Chem. 2012 Oct 19; 287(43):36305-11. PMID: 22893704; PMCID: PMC3476297.
    24. Chae PS, Rasmussen SG, Rana RR, Gotfryd K, Kruse AC, Manglik A, Cho KH, Nurva S, Gether U, Guan L, Loland CJ, Byrne B, Kobilka BK, Gellman SH. A new class of amphiphiles bearing rigid hydrophobic groups for solubilization and stabilization of membrane proteins. Chemistry. 2012 Jul 27; 18(31):9485-90. PMID: 22730191; PMCID: PMC3493560.
    25. Granier S, Manglik A, Kruse AC, Kobilka TS, Thian FS, Weis WI, Kobilka BK. Structure of the δ-opioid receptor bound to naltrindole. Nature. 2012 May 16; 485(7398):400-4. PMID: 22596164; PMCID: PMC3523198.
    26. Manglik A, Kruse AC, Kobilka TS, Thian FS, Mathiesen JM, Sunahara RK, Pardo L, Weis WI, Kobilka BK, Granier S. Crystal structure of the µ-opioid receptor bound to a morphinan antagonist. Nature. 2012 Mar 21; 485(7398):321-6. PMID: 22437502; PMCID: PMC3523197.
    27. Flentie KN, Qi M, Gammon ST, Razia Y, Lui F, Marpegan L, Manglik A, Piwnica-Worms D, McKinney JS. Stably integrated luxCDABE for assessment of Salmonella invasion kinetics. Mol Imaging. 2008 Sep-Oct; 7(5):222-33. PMID: 19123992; PMCID: PMC2743400.
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