CLINICAL INTERESTS: Dr. Olgin is a Cardiologist and a Cardiac Electrophysiologist. His main clinical interests include conduction disorders, arrhythmias, catheter ablation, implantable devices—pacemakers and defibrillators, atrial fibrillation, atrial flutter, ventricular tachycardia, sudden death and supraventricular tachycardia.
RESEARCH INTERESTS: Mechanisms of arrhythmias, remodeling and cardiac fibrosis, atrial fibrillation, ventricular fibrillation, sudden death, prediction of atrial fibrillation, prediction of sudden death, mobile health and clinical trials.
Dr. Olgin's basic research lab is interested in atrial and ventricular remodeling and how these processes occur to develop a substrate for atrial fibrillation and ventricular tachycardia. His work has demonstrated the circuit for human atrial flutter and has demonstrated the importance of atrial fibrosis as a cause for atrial fibrillation. He is currently interested in how TGFß signaling is regulated in the atria to produce atrial fibrosis and atrial fibrillation. His lab is translational in that he utilizes a spectrum of techniques and studies that span from mouse, large animal physiologic models, human tissue, human biomarkers and genetic approaches to understanding the disease. He also has active studies in understanding the remodeling that occurs in the ventricle in the setting of heart failure and myocardial infarction to create the substrate for sudden death and ventricular tachycardia and fibrillation.
Dr. Olgin’s clinical research has focused on atrial fibrillation and sudden cardiac death mechanisms, epidemiology, genetics and interventions. He has run clinical trial coordinating centers. He has developed mobile and digital health tools for performing large, pragmatic research studies. He has developed the Health eHeart Study, an eCohort to study cardiovascular disease prevention and to validate mobile health applications in disease outcomes studies, with many studies using the platform and over 300,000 participants recruited. This novel approach to doing clinical trials has been expanded beyond cardiovascular disease through an NIH grant to create the Eureka Research Platform for Mobilized Research. Through all of these programs, we have developed the infrastructure and experience to manage large blended teams of software developers, designers and research coordinators, data managers and epidemiologists to create a novel “digital” coordinating center.