Ari Green, MD

Title(s)Professor, Neurology
SchoolSchool of Medicine
Address675 Nelson Rising Lane, #216A
San Francisco CA 94158
Phone415-260-9674
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    Other Positions
    Title(s)UCSF Weill Institute for Neurosciences


    Collapse Biography 
    Collapse Education and Training
    Miami University BA/BS Economics/ Philosophy/Physics Medicine
    Duke University MD Medicine
    University of California, San Francisco Intern. Medicine
    University of California, San Francisco Residency Neurology
    University of California, San Francisco Fellowship Neuroimmunology
    University of California, San Francisco Fellowship Neuro-ophthalmology
    University of California, San FranciscoMCR Clinical Research
    Queen’s University BelfastVisiting FellowNeuropath (retina)
    Collapse Awards and Honors
    1990Edward and Mary Shepherd Scholar
    1991University Scholar leader award
    1991Silber fellowship American Cancer Society
    1994Magna Cum Laude with Honors
    1994President’s Distinguished Service Award
    1996Teaching/Service Award Franklinton County Schools
    1998  - 2000Howard Hughes Medical Institute Predoctoral Fellowship
    2005Chief Resident in Neurology
    2008NIH Loan repayment program recipient
    2005NIH Loan repayment program recipient
    2006AAN Foundation Research Fellow Award
    2008HHMI Early Clinician Scientist Award
    2009Debbie and Andy Rachleff Distinguished Professor in Neurology
    2012CTSI T1 Catalyst Award
    2012Harry Weaver Neuroscience Scholar (National MS Society)
    2015UCSF Distinguished Professors Dinner Keynote
    2021AAN Expert Review Advisory Panels

    Collapse Overview 
    Collapse Overview
    Dr. Ari J Green is the Chief of the Division of Neuroimmunology and Glial Biology in the Department of Neurology at the University of California at San Francisco. His team consists of more than 20 laboratories and groups dedicated to discovering the causes of Multiple Sclerosis and related disorders; and to developing treatments as well as cures for these conditions. Dr. Green is also Medical Director of the UCSF MS and Neuroinflammation Center – one of the largest clinics of its kind in the United States with a broad focus on caring for patients with conditions in which immune dysregulation or inflammation play an important role. The clinic seeks to provide comprehensive, patient-centered care for people living with these diseases with a wide variety of ancillary services for diagnosis, monitoring and supporting patients and their families. Dr. Green’s laboratory is dedicated to the biological validation of potential biomarkers intended to measure remyelination and repair (as well as progression) in MS as a means to accelerate clinical trials for reparative treatments. His major scientific contributions include directing the first successful phase II clinical trial of a remyelinating agent for MS, developing methods for monitoring myelin repair, detailing the histopathological changes in the retina seen in MS, and describing the role of progranulin in the retina along with discovering a previously unknown retinal phenotype in progranulin-related frontotemporal dementia. His lab maintains an active interest in the developing and validating biomarkers for neurodegenerative disease generally and inflammatory diseases of the central nervous system in particular. He also co-directs the Program in Remyelination and Repair with Dr. Jonah Chan as well as the Neurodiagnostics Center in the Department of Neurology.

    Dr. Green completed medical school at Duke University School of Medicine in 2001 (during which time he had a Howard Hughes Medical Institute predoctoral fellowship with Drs. Jorge Oksenberg and Stephen L Hauser) and Internship in the Department of Medicine at UCSF in 2002. He completed Residency training at UCSF including Chief Residency in Neurology and post residency fellowships in Neuroimmunology under Dr. Stephen Hauser and Neuro-ophthalmology under Drs. William F. Hoyt and Kimberly Cockerham at UCSF. He then had a visiting fellowship at Queen’s University Belfast under Dame Ingrid Allen in Neuropathology. He was named the first AAN/NMSS Clinician Science Fellow in 2005 and received a Howard Hughes Clinician Scientist award from HHMI. He was named as the Debbie and Andy Rachleff Distinguished Professor of Neurology in 2009 and joined the Department of Ophthalmology at UCSF in 2011. He was a Harry Weaver Neuroscience Scholar and has served as Associate Editor for JAMA Neurology since 2017.

    The Division of Neuroimmunology and Glial Biology - since its inception under the leadership of Dr. Stephen Hauser in 1992 - has made major contributions to all aspects of the biology of MS and its treatment including defining the full genetic risk profile for MS, discovering the importance of B cell biology in MS, improving our understanding of adaptive immune processes in inflammatory diseases of the brain and making groundbreaking discoveries in therapeutics for repair and remyelination in MS and other demyelinating diseases. The group continues to be focused on breakthrough developments in the field including microbiome research, glial biology work, and working to uncover the triggers of MS and other inflammatory diseases of the CNS. Under Dr. Green’s leadership, the group has expanded its focus to investigate new methods for understanding infectious and inflammatory diseases of the brain as well as developmental and autoimmune disorders of the CNS that lead to neurological disability. The Division is also a leading force for the education of trainees in clinical care, scientific disciplines and graduate studies in all areas related to our clinical and research mission. We actively train clinical fellows, residents, students and community members in issues of importance to our patients and their families.

    Collapse Research 
    Collapse Research Activities and Funding
    Adelson Medical Research Foundation
    04-7023433Oct 1, 2019 - Sep 30, 2020
    Role: Co-Investigator
    Tracking Longitudinal Change in Presymptomatic Genetic Prion Disease (TLC-Pre-gPrD)
    NIH R01 AG062562-01Aug 1, 2019 - May 31, 2024
    Role: Co-Investigator
    Establishing VEP as a quantitative biomarker for remyelination using transgenic models for gain and loss of function
    NIH/NINDS R01NS105741May 15, 2018 - Feb 28, 2023
    Establishing VEP as a quantitative biomarker for remyelination using transgenic models for gain and loss of function
    NIH R01NS105741May 15, 2018 - Feb 28, 2023
    Role: Principal Investigator
    Functional validation of SERMs as remyelinating agents
    NMSS RG-1707-28564Apr 1, 2018 - Mar 31, 2021
    Role: Co-Investigator
    Goal:Functional Screening of GPCR Small Molecule Libraries for Remyelination Therapies
    NIH R01 NS095889Oct 1, 2016 - Sep 30, 2021
    Role: Co-Investigator
    Somatodendritic Inhibition of Oligodendrocyte Myelination
    NIH R01 NS062796Jun 1, 2016 - Feb 28, 2021
    Role: Co-Investigator
    The Four Repeat Tauopathy Neuroimaging Initiative
    NIH/NIA R01AG038791Mar 1, 2016 - Feb 28, 2021
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Synaptic injury in the inner plexiform layer of the retina is associated with progression in multiple sclerosis. Cell Rep Med. 2024 Mar 26; 101490. Cordano C, Werneburg S, Abdelhak A, Bennett DJ, Beaudry-Richard A, Duncan GJ, Oertel FC, Boscardin WJ, Yiu HH, Jabassini N, Merritt L, Nocera S, Sin JH, Samana IP, Condor Montes SY, Ananth K, Bischof A, UCSF MS EPIC Team, Nourbakhsh B, Hauser SL, Cree BAC, Emery B, Schafer DP, Chan JR, Green AJ. PMID: 38574736.
      View in: PubMed   Mentions:    Fields:    
    2. Minimum Effective Dose of Clemastine in a Mouse Model of Preterm White Matter Injury. bioRxiv. 2024 Mar 01. Odell E, Jabassini N, Schniedewind B, Pease-Raissi SE, Frymoyer A, Christians U, Green AJ, Chan JR, Ostrem BEL. PMID: 38464078; PMCID: PMC10925142.
      View in: PubMed   Mentions:
    3. Scientific commentary on: "Phosphorylated tau in the retina correlates with tau pathology in the brain in Alzheimer's disease and primary tauopathies". Acta Neuropathol. 2024 Feb 03; 147(1):30. Oertel FC, Casillas D, Cobigo Y, Condor Montes S, Heuer HW, Chapman M, Beaudry-Richard A, Reinsberg H, Abdelhak A, Cordano C, Boeve BF, Dickerson BC, Grossman M, Huey E, Irwin DJ, Litvan I, Pantelyat A, Tartaglia MC, Vandevrede L, Boxer A, Green AJ. PMID: 38308717; PMCID: PMC10838223.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. Identification and In Vivo Evaluation of Myelination Agent PIPE-3297, a Selective Kappa Opioid Receptor Agonist Devoid of β-Arrestin-2 Recruitment Efficacy. ACS Chem Neurosci. 2024 Feb 07; 15(3):685-698. Schrader TO, Lorrain KI, Bagnol D, Edu GC, Broadhead A, Baccei C, Poon MM, Stebbins KJ, Xiong Y, Lorenzana AO, Chan JR, Green AJ, Lorrain DS, Chen A. PMID: 38265210.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    5. Neurofilament Light Chain Elevation and Disability Progression in Multiple Sclerosis. JAMA Neurol. 2023 Dec 01; 80(12):1317-1325. Abdelhak A, Benkert P, Schaedelin S, Boscardin WJ, Cordano C, Oechtering J, Ananth K, Granziera C, Melie-Garcia L, Montes SC, Beaudry-Richard A, Achtnichts L, Oertel FC, Lalive PH, Leppert D, Müller S, Henry RG, Pot C, Matthias A, Salmen A, Oksenberg JR, Disanto G, Zecca C, D'Souza M, Du Pasquier R, Bridel C, Gobbi C, Kappos L, Hauser SL, Cree BAC, Kuhle J, Green AJ, UCSF, MS EPIC, and the SMSC Study Teams. PMID: 37930670; PMCID: PMC10628837.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    6. Patient-reported outcome parameters and disability worsening in progressive multiple sclerosis. Mult Scler Relat Disord. 2024 Jan; 81:105139. Abdelhak A, Antweiler K, Kowarik MC, Senel M, Havla J, Zettl UK, Kleiter I, Hoshi MM, Skripuletz T, Haarmann A, Stahmann A, Huss A, Gingele S, Krumbholz M, Selge C, Friede T, Ludolph AC, Overell J, Koendgen H, Clinch S, Wang Q, Ziemann U, Hauser SL, Kümpfel T, Green AJ, Tumani H. PMID: 38000130; PMCID: PMC10959125.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    7. Remyelination protects neurons from DLK-mediated neurodegeneration. bioRxiv. 2023 Oct 12. Duncan GJ, Ingram SD, Emberley K, Hill J, Cordano C, Abdelhak A, McCane M, Jabassini N, Ananth K, Ferrara SJ, Stedelin B, Sivyer B, Aicher SA, Scanlan T, Watkins TA, Mishra A, Nelson J, Green AJ, Emery B. PMID: 37873342; PMCID: PMC10592610.
      View in: PubMed   Mentions:
    8. Retinal Changes After Acute and Late Optic Neuritis in Aquaporin-4 Antibody Seropositive NMOSD. J Neuroophthalmol. 2023 Sep 29. Oertel FC, Zimmermann HG, Motamedi S, Bereuter C, Asseyer ES, Chien C, Marignier R, Cobo-Calvo A, Leocani L, Pisa M, Radaelli M, Villoslada P, Sanchez-Dalmau B, Martinez-Lapiscina EH, Lana-Peixoto MA, Fontenelle MA, Aktas O, Ringelstein M, Albrecht P, Green AJ, Yeaman MR, Smith TJ, Cook L, Paul F, Brandt AU. PMID: 37782525.
      View in: PubMed   Mentions:    Fields:    
    9. Attack adjudication in neuromyelitis optica spectrum disorder: Substantiation of criteria by magnetic resonance imaging and biomarkers in N-MOmentum. Mult Scler. 2023 07; 29(8):945-955. Weinshenker BG, Wingerchuk DM, Green AJ, Bennett JL, Kim HJ, Pittock SJ, Fujihara K, Paul F, Cutter G, Marignier R, Aktas O, Hartung HP, She D, Smith M, Rees W, Patterson K, Cimbora D, Katz E, Cree BA. PMID: 37282545; PMCID: PMC10338695.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    10. Challenges and Opportunities for the Promising Biomarker Blood Neurofilament Light Chain. JAMA Neurol. 2023 06 01; 80(6):542-543. Abdelhak A, Kuhle J, Green AJ. PMID: 37010852.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    11. Imaging immunomodulatory treatment responses in a multiple sclerosis mouse model using hyperpolarized 13C metabolic MRI. Commun Med (Lond). 2023 May 22; 3(1):71. Guglielmetti C, Cordano C, Najac C, Green AJ, Chaumeil MM. PMID: 37217574; PMCID: PMC10202949.
      View in: PubMed   Mentions: 1  
    12. Prognostic performance of blood neurofilament light chain protein in hospitalized COVID-19 patients without major central nervous system manifestations: an individual participant data meta-analysis. J Neurol. 2023 Jul; 270(7):3315-3328. Abdelhak A, Barba L, Romoli M, Benkert P, Conversi F, D'Anna L, Masvekar RR, Bielekova B, Prudencio M, Petrucelli L, Meschia JF, Erben Y, Furlan R, De Lorenzo R, Mandelli A, Sutter R, Hert L, Epple V, Marastoni D, Sellner J, Steinacker P, Aamodt AH, Heggelund L, Dyrhol-Riise AM, Virhammar J, Fällmar D, Rostami E, Kumlien E, Blennow K, Zetterberg H, Tumani H, Sacco S, Green AJ, Otto M, Kuhle J, Ornello R, Foschi M, Abu-Rumeileh S. PMID: 37184659; PMCID: PMC10183689.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    13. A Predictive Autoantibody Signature in Multiple Sclerosis. medRxiv. 2023 May 15. Zamecnik CR, Sowa GM, Abdelhak A, Dandekar R, Bair RD, Wade KJ, Bartley CM, Tubati A, Gomez R, Fouassier C, Gerungan C, Alexander J, Wapniarski AE, Loudermilk RP, Eggers EL, Zorn KC, Ananth K, Jabassini N, Mann SA, Ragan NR, Santaniello A, Henry RG, Baranzini SE, Zamvil SS, Bove RM, Guo CY, Gelfand JM, Cuneo R, von Büdingen HC, Oksenberg JR, Cree BA, Hollenbach JA, Green AJ, Hauser SL, Wallin MT, DeRisi JL, Wilson MR. PMID: 37205595; PMCID: PMC10187343.
      View in: PubMed   Mentions:
    14. MWF of the corpus callosum is a robust measure of remyelination: Results from the ReBUILD trial. Proc Natl Acad Sci U S A. 2023 05 16; 120(20):e2217635120. Caverzasi E, Papinutto N, Cordano C, Kirkish G, Gundel TJ, Zhu A, Akula AV, Boscardin WJ, Neeb H, Henry RG, Chan JR, Green AJ. PMID: 37155847; PMCID: PMC10193980.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    15. Neuron-oligodendrocyte potassium shuttling at nodes of Ranvier protects against inflammatory demyelination. J Clin Invest. 2023 04 03; 133(7). Kapell H, Fazio L, Dyckow J, Schwarz S, Cruz-Herranz A, Mayer C, Campos J, D'Este E, Möbius W, Cordano C, Pröbstel AK, Gharagozloo M, Zulji A, Narayanan Naik V, Delank A, Cerina M, Müntefering T, Lerma-Martin C, Sonner JK, Sin JH, Disse P, Rychlik N, Sabeur K, Chavali M, Srivastava R, Heidenreich M, Fitzgerald KC, Seebohm G, Stadelmann C, Hemmer B, Platten M, Jentsch TJ, Engelhardt M, Budde T, Nave KA, Calabresi PA, Friese MA, Green AJ, Acuna C, Rowitch DH, Meuth SG, Schirmer L. PMID: 36719741; PMCID: PMC10065072.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    16. Visually Evoked Potential as Prognostic Biomarker for Neuroaxonal Damage in Multiple Sclerosis From a Multicenter Longitudinal Cohort. Neurol Neuroimmunol Neuroinflamm. 2023 05; 10(3). Oertel FC, Krämer J, Motamedi S, Keihani A, Zimmermann HG, Dimitriou NG, Condor-Montes S, Bereuter C, Cordano C, Abdelhak A, Trip A, Aktas O, Meuth SG, Wiendl H, Ruprecht K, Bellmann-Strobl J, Paul F, Petzold A, Brandt AU, Albrecht P, Green AJ. PMID: 36878713; PMCID: PMC10026703.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    17. Diagnostic value of intereye difference metrics for optic neuritis in aquaporin-4 antibody seropositive neuromyelitis optica spectrum disorders. J Neurol Neurosurg Psychiatry. 2023 07; 94(7):560-566. Oertel FC, Zimmermann HG, Motamedi S, Chien C, Aktas O, Albrecht P, Ringelstein M, Dcunha A, Pandit L, Martinez-Lapiscina EH, Sanchez-Dalmau B, Villoslada P, Palace J, Roca-Fernández A, Leite MI, Sharma SM, Leocani L, Pisa M, Radaelli M, Lana-Peixoto MA, Fontenelle MA, Havla J, Ashtari F, Kafieh R, Dehghani A, Pourazizi M, Marignier R, Cobo-Calvo A, Asgari N, Jacob A, Huda S, Mao-Draayer Y, Green AJ, Kenney R, Yeaman MR, Smith TJ, Cook L, Brandt AU, Paul F, Petzold A. PMID: 36810323; PMCID: PMC10314042.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    18. Tailoring a home-based, multidisciplinary deprescribing intervention through clinicians and community-dwelling older adults. J Am Geriatr Soc. 2023 05; 71(5):1663-1666. Lee JW, Boyd CM, Leff B, Green A, Hornstein E, LaFave S, Seau Q, Nkodo A, Kachur S, Williams N, Riser T, Szanton SL. PMID: 36515689; PMCID: PMC10175124.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    19. Validating visual evoked potentials as a preclinical, quantitative biomarker for remyelination efficacy. Brain. 2022 11 21; 145(11):3943-3952. Cordano C, Sin JH, Timmons G, Yiu HH, Stebbins K, Guglielmetti C, Cruz-Herranz A, Xin W, Lorrain D, Chan JR, Green AJ. PMID: 35678509; PMCID: PMC10200282.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    20. Differences in Age-related Retinal and Cortical Atrophy Rates in Multiple Sclerosis. Neurology. 2022 10 11; 99(15):e1685-e1693. Cordano C, Nourbakhsh B, Yiu HH, Papinutto N, Caverzasi E, Abdelhak A, Oertel FC, Beaudry-Richard A, Santaniello A, Sacco S, Bennett DJ, Gomez A, Sigurdson CJ, Hauser SL, Magliozzi R, Cree BAC, Henry RG, Green AJ. PMID: 36038272; PMCID: PMC9559941.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    21. Longitudinal Retinal Changes in MOGAD. Ann Neurol. 2022 09; 92(3):476-485. Oertel FC, Sotirchos ES, Zimmermann HG, Motamedi S, Specovius S, Asseyer ES, Chien C, Cook L, Vasileiou E, Filippatou A, Calabresi PA, Saidha S, Pandit L, D'Cunha A, Outteryck O, Zéphir H, Pittock S, Flanagan EP, Bhatti MT, Rommer PS, Bsteh G, Zrzavy T, Kuempfel T, Aktas O, Ringelstein M, Albrecht P, Ayzenberg I, Pakeerathan T, Knier B, Aly L, Asgari N, Soelberg K, Marignier R, Tilikete CF, Cobo Calvo A, Villoslada P, Sanchez-Dalmau B, Martinez-Lapiscina EH, Llufriu S, Green AJ, Yeaman MR, Smith TJ, Brandt AU, Chen J, Paul F, Havla J, with the GJCF International Clinical Consortium for NMOSD and the CROCTINO study group. PMID: 35703428.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    22. Retinal arteriolar parameters as a surrogate marker of intracranial vascular pathology. Alzheimers Dement (Amst). 2022; 14(1):e12338. Abdelhak A, Solomon I, Montes SC, Saias A, Cordano C, Asken B, Fonseca C, Oertel FC, Arfanakis K, Staffaroni AM, Kramer JH, Geschwind M, Miller BL, Elahi FM, Green AJ. PMID: 35814617; PMCID: PMC9257197.
      View in: PubMed   Mentions: 1  
    23. Plasma neurofilament light chain levels suggest neuroaxonal stability following therapeutic remyelination in people with multiple sclerosis. J Neurol Neurosurg Psychiatry. 2022 Jun 16. Abdelhak A, Cordano C, Boscardin WJ, Caverzasi E, Kuhle J, Chan B, Gelfand JM, Yiu HH, Oertel FC, Beaudry-Richard A, Condor Montes S, Oksenberg JR, Lario Lago A, Boxer A, Rojas-Martinez JC, Elahi FM, Chan JR, Green AJ. PMID: 35710320; PMCID: PMC9984688.
      View in: PubMed   Mentions: 3     Fields:    
    24. Transitioning From S1P Receptor Modulators to B Cell-Depleting Therapies in Multiple Sclerosis: Clinical, Radiographic, and Laboratory Data. Neurol Neuroimmunol Neuroinflamm. 2022 07; 9(4). Rowles WM, Hsu WY, McPolin K, Li A, Merrill S, Guo CY, Green AJ, Gelfand JM, Bove RM. PMID: 35581005; PMCID: PMC9128034.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    25. Reply to "Interpretation of Longitudinal Changes of the Inner Nuclear Layer in MS". Ann Neurol. 2022 07; 92(1):156. Cordano C, Yiu HH, Abdelhak A, Beaudry-Richard A, Oertel FC, Green AJ. PMID: 35403744.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    26. Reply to "Spinal Cord Atrophy Is a Preclinical Marker of Progressive MS". Ann Neurol. 2022 05; 91(5):735-736. Bischof A, Papinutto N, Keshavan A, Rajesh A, Kirkish G, Zhang X, Mallott JM, Asteggiano C, Sacco S, Gundel TJ, Zhao C, Stern WA, Caverzasi E, Zhou Y, Gomez R, Ragan NR, Santaniello A, Zhu AH, Juwono J, Bevan CJ, Bove RM, Crabtree-Hartman E, Gelfand JM, Goodin DS, Graves JS, Green AJ, Oksenberg JR, Waubant E, Wilson MR, Zamvil SS, University of California, San Francisco MS-EPIC Team, Cree BA, Hauser SL, Henry RG. PMID: 35233827; PMCID: PMC9511767.
      View in: PubMed   Mentions:    Fields:    
    27. A hormonal therapy for menopausal women with MS: A phase Ib/IIa randomized controlled trial. Mult Scler Relat Disord. 2022 May; 61:103747. Bove R, Anderson A, Rowles W, Rankin KA, Hills NK, Carleton M, Cooper J, Cree BAC, Gelfand JM, Graves JS, Henry RG, Krysko KM, Rush G, Zamvil SS, Joffe H, Chan JR, Green AJ. PMID: 35397292.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCTClinical Trials
    28. Blood GFAP as an emerging biomarker in brain and spinal cord disorders. Nat Rev Neurol. 2022 03; 18(3):158-172. Abdelhak A, Foschi M, Abu-Rumeileh S, Yue JK, D'Anna L, Huss A, Oeckl P, Ludolph AC, Kuhle J, Petzold A, Manley GT, Green AJ, Otto M, Tumani H. PMID: 35115728.
      View in: PubMed   Mentions: 115     Fields:    Translation:HumansCells
    29. Characterizing Fixational Eye Motion Variance Over Time as Recorded by the Tracking Scanning Laser Ophthalmoscope. Transl Vis Sci Technol. 2022 Feb 01; 11(2):35. Condor Montes SY, Bennett D, Bensinger E, Rani L, Sherkat Y, Zhao C, Helft Z, Roorda A, Green AJ, Sheehy CK. PMID: 35201339; PMCID: PMC8883154.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    30. Spinal Cord Atrophy Predicts Progressive Disease in Relapsing Multiple Sclerosis. Ann Neurol. 2022 02; 91(2):268-281. Bischof A, Papinutto N, Keshavan A, Rajesh A, Kirkish G, Zhang X, Mallott JM, Asteggiano C, Sacco S, Gundel TJ, Zhao C, Stern WA, Caverzasi E, Zhou Y, Gomez R, Ragan NR, Santaniello A, Zhu AH, Juwono J, Bevan CJ, Bove RM, Crabtree E, Gelfand JM, Goodin DS, Graves JS, Green AJ, Oksenberg JR, Waubant E, Wilson MR, Zamvil SS, University of California, San Francisco MS-EPIC Team, Cree BAC, Hauser SL, Henry RG. PMID: 34878197; PMCID: PMC8916838.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    31. Socioeconomic disadvantage in multiple sclerosis: does inequality act on the substrate for disability? Brain. 2021 12 31; 144(12):3552-3554. Green AJ. PMID: 34927667.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    32. Interocular Difference in Retinal Nerve Fiber Layer Thickness Predicts Optic Neuritis in Pediatric-Onset Multiple Sclerosis. J Neuroophthalmol. 2021 12 01; 41(4):469-475. Waldman AT, Benson L, Sollee JR, Lavery AM, Liu GW, Green AJ, Waubant E, Heidary G, Conger D, Graves J, Greenberg B. PMID: 33105412; PMCID: PMC8846428.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    33. Optical coherence tomography in multiple sclerosis: A 3-year prospective multicenter study. Ann Clin Transl Neurol. 2021 12; 8(12):2235-2251. Paul F, Calabresi PA, Barkhof F, Green AJ, Kardon R, Sastre-Garriga J, Schippling S, Vermersch P, Saidha S, Gerendas BS, Schmidt-Erfurth U, Agoropoulou C, Zhang Y, Seifer G, Petzold A. PMID: 34792863; PMCID: PMC8670323.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    34. AQP4-IgG-seronegative patient outcomes in the N-MOmentum trial of inebilizumab in neuromyelitis optica spectrum disorder. Mult Scler Relat Disord. 2022 Jan; 57:103356. Marignier R, Pittock SJ, Paul F, Kim HJ, Bennett JL, Weinshenker BG, Wingerchuk DM, Green AJ, Fujihara K, Cutter G, Aktas O, Hartung HP, Drappa J, Ratchford JN, She D, Smith M, Rees W, Cimbora D, Katz E, Cree BAC, N-MOmentum study investigators. PMID: 35158465.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    35. Astrocytic outer retinal layer thinning is not a feature in AQP4-IgG seropositive neuromyelitis optica spectrum disorders. J Neurol Neurosurg Psychiatry. 2022 02; 93(2):188-195. Lu A, Zimmermann HG, Specovius S, Motamedi S, Chien C, Bereuter C, Lana-Peixoto MA, Fontenelle MA, Ashtari F, Kafieh R, Dehghani A, Pourazizi M, Pandit L, D'Cunha A, Kim HJ, Hyun JW, Jung SK, Leocani L, Pisa M, Radaelli M, Siritho S, May EF, Tongco C, De Sèze J, Senger T, Palace J, Roca-Fernández A, Leite MI, Sharma SM, Stiebel-Kalish H, Asgari N, Soelberg KK, Martinez-Lapiscina EH, Havla J, Mao-Draayer Y, Rimler Z, Reid A, Marignier R, Cobo-Calvo A, Altintas A, Tanriverdi U, Yildirim R, Aktas O, Ringelstein M, Albrecht P, Tavares IM, Bichuetti DB, Jacob A, Huda S, Soto de Castillo I, Petzold A, Green AJ, Yeaman MR, Smith TJ, Cook L, Paul F, Brandt AU, Oertel FC, GJCF International Clinical Consortium for NMOSD. PMID: 34711650; PMCID: PMC8785057.
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    39. Retinal imaging demonstrates reduced capillary density in clinically unimpaired APOE ε4 gene carriers. Alzheimers Dement (Amst). 2021; 13(1):e12181. Elahi FM, Ashimatey SB, Bennett DJ, Walters SM, La Joie R, Jiang X, Wolf A, Cobigo Y, Staffaroni AM, Rosen HJ, Miller BL, Rabinovici GD, Kramer JH, Green AJ, Kashani AH. PMID: 34013017; PMCID: PMC8111703.
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    43. Underutilization of physical therapy for symptomatic women with MS during and following pregnancy. Mult Scler Relat Disord. 2021 Feb; 48:102703. Block VJ, Mestas O, Anderson A, Singh J, Wylie L, Guo CY, Green AJ, Gelfand JM, Bove R. PMID: 33387862.
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    44. Retinal INL Thickness in Multiple Sclerosis: A Mere Marker of Neurodegeneration? Ann Neurol. 2021 01; 89(1):192-193. Cordano C, Yiu HH, Oertel FC, University of California, San Francisco MS-EPIC Team, Gelfand JM, Hauser SL, Cree BAC, Green AJ. PMID: 33067847; PMCID: PMC7990472.
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    45. Neurite Orientation Dispersion and Density Imaging for Assessing Acute Inflammation and Lesion Evolution in MS. AJNR Am J Neuroradiol. 2020 12; 41(12):2219-2226. Sacco S, Caverzasi E, Papinutto N, Cordano C, Bischof A, Gundel T, Cheng S, Asteggiano C, Kirkish G, Mallott J, Stern WA, Bastianello S, Bove RM, Gelfand JM, Goodin DS, Green AJ, Waubant E, Wilson MR, Zamvil SS, Cree BA, Hauser SL, Henry RG, University of California, San Francisco MS-EPIC Team. PMID: 33154077; PMCID: PMC7963254.
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    46. Importance of Not MSing Cerebral White Matter Disease in Patients with Inflammatory Bowel Disease. Dig Dis Sci. 2020 09; 65(9):2527-2532. Regner EH, Green AJ, Bain JL, Kattah MG, Mahadevan U. PMID: 32651742.
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    48. A pathogenic and clonally expanded B cell transcriptome in active multiple sclerosis. Proc Natl Acad Sci U S A. 2020 09 15; 117(37):22932-22943. Ramesh A, Schubert RD, Greenfield AL, Dandekar R, Loudermilk R, Sabatino JJ, Koelzer MT, Tran EB, Koshal K, Kim K, Pröbstel AK, Banerji D, University of California, San Francisco MS-EPIC Team, Guo CY, Green AJ, Bove RM, DeRisi JL, Gelfand JM, Cree BAC, Zamvil SS, Baranzini SE, Hauser SL, Wilson MR. PMID: 32859762; PMCID: PMC7502747.
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    50. The Spectrum of Neurologic Disease in the Severe Acute Respiratory Syndrome Coronavirus 2 Pandemic Infection: Neurologists Move to the Frontlines. JAMA Neurol. 2020 06 01; 77(6):679-680. Pleasure SJ, Green AJ, Josephson SA. PMID: 32275291.
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    60. Association of Continuous Assessment of Step Count by Remote Monitoring With Disability Progression Among Adults With Multiple Sclerosis. JAMA Netw Open. 2019 03 01; 2(3):e190570. Block VJ, Bove R, Zhao C, Garcha P, Graves J, Romeo AR, Green AJ, Allen DD, Hollenbach JA, Olgin JE, Marcus GM, Pletcher MJ, Cree BAC, Gelfand JM. PMID: 30874777; PMCID: PMC6484622.
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    61. Potential Benefits of Early Aggressive Treatment in Multiple Sclerosis. JAMA Neurol. 2019 03 01; 76(3):254-256. Green AJ. PMID: 30644966.
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    62. Selective Estrogen Receptor Modulators Enhance CNS Remyelination Independent of Estrogen Receptors. J Neurosci. 2019 03 20; 39(12):2184-2194. Rankin KA, Mei F, Kim K, Shen YA, Mayoral SR, Desponts C, Lorrain DS, Green AJ, Baranzini SE, Chan JR, Bove R. PMID: 30696729; PMCID: PMC6433770.
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    86. Tolerance checkpoint bypass permits emergence of pathogenic T cells to neuromyelitis optica autoantigen aquaporin-4. Proc Natl Acad Sci U S A. 2016 12 20; 113(51):14781-14786. Sagan SA, Winger RC, Cruz-Herranz A, Nelson PA, Hagberg S, Miller CN, Spencer CM, Ho PP, Bennett JL, Levy M, Levin MH, Verkman AS, Steinman L, Green AJ, Anderson MS, Sobel RA, Zamvil SS. PMID: 27940915; PMCID: PMC5187685.
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    87. Whole-body positional manipulators for ocular imaging of anaesthetised mice and rats: a do-it-yourself guide. BMJ Open Ophthalmol. 2017; 1(1):e000008. Dietrich M, Cruz-Herranz A, Yiu H, Aktas O, Brandt AU, Hartung HP, Green A, Albrecht P. PMID: 29354694; PMCID: PMC5759402.
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    88. Accelerated remyelination during inflammatory demyelination prevents axonal loss and improves functional recovery. Elife. 2016 Sep 27; 5. Mei F, Lehmann-Horn K, Shen YA, Rankin KA, Stebbins KJ, Lorrain DS, Pekarek K, A Sagan S, Xiao L, Teuscher C, von Büdingen HC, Wess J, Lawrence JJ, Green AJ, Fancy SP, Zamvil SS, Chan JR. PMID: 27671734; PMCID: PMC5039026.
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    89. Long-term evolution of multiple sclerosis disability in the treatment era. Ann Neurol. 2016 10; 80(4):499-510. University of California, San Francisco MS-EPIC Team:, Cree BA, Gourraud PA, Oksenberg JR, Bevan C, Crabtree-Hartman E, Gelfand JM, Goodin DS, Graves J, Green AJ, Mowry E, Okuda DT, Pelletier D, von Büdingen HC, Zamvil SS, Agrawal A, Caillier S, Ciocca C, Gomez R, Kanner R, Lincoln R, Lizee A, Qualley P, Santaniello A, Suleiman L, Bucci M, Panara V, Papinutto N, Stern WA, Zhu AH, Cutter GR, Baranzini S, Henry RG, Hauser SL. PMID: 27464262; PMCID: PMC5105678.
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    90. Identification of the Kappa-Opioid Receptor as a Therapeutic Target for Oligodendrocyte Remyelination. J Neurosci. 2016 07 27; 36(30):7925-35. Mei F, Mayoral SR, Nobuta H, Wang F, Desponts C, Lorrain DS, Xiao L, Green AJ, Rowitch D, Whistler J, Chan JR. PMID: 27466337; PMCID: PMC4961778.
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    91. Sex differences and subclinical retinal injury in pediatric-onset MS. Mult Scler. 2017 Mar; 23(3):447-455. Graves JS, Chohan H, Cedars B, Arnow S, Yiu H, Waubant E, Green A. PMID: 27306618.
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    92. The APOSTEL recommendations for reporting quantitative optical coherence tomography studies. Neurology. 2016 Jun 14; 86(24):2303-9. Cruz-Herranz A, Balk LJ, Oberwahrenbrock T, Saidha S, Martinez-Lapiscina EH, Lagreze WA, Schuman JS, Villoslada P, Calabresi P, Balcer L, Petzold A, Green AJ, Paul F, Brandt AU, Albrecht P, IMSVISUAL consortium. PMID: 27225223; PMCID: PMC4909557.
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    93. Timing of retinal neuronal and axonal loss in MS: a longitudinal OCT study. J Neurol. 2016 Jul; 263(7):1323-31. Balk LJ, Cruz-Herranz A, Albrecht P, Arnow S, Gelfand JM, Tewarie P, Killestein J, Uitdehaag BM, Petzold A, Green AJ. PMID: 27142714; PMCID: PMC4929170.
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    94. Retinal thickness measured with optical coherence tomography and risk of disability worsening in multiple sclerosis: a cohort study. Lancet Neurol. 2016 May; 15(6):574-84. Martinez-Lapiscina EH, Arnow S, Wilson JA, Saidha S, Preiningerova JL, Oberwahrenbrock T, Brandt AU, Pablo LE, Guerrieri S, Gonzalez I, Outteryck O, Mueller AK, Albrecht P, Chan W, Lukas S, Balk LJ, Fraser C, Frederiksen JL, Resto J, Frohman T, Cordano C, Zubizarreta I, Andorra M, Sanchez-Dalmau B, Saiz A, Bermel R, Klistorner A, Petzold A, Schippling S, Costello F, Aktas O, Vermersch P, Oreja-Guevara C, Comi G, Leocani L, Garcia-Martin E, Paul F, Havrdova E, Frohman E, Balcer LJ, Green AJ, Calabresi PA, Villoslada P, IMSVISUAL consortium. PMID: 27011339.
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    95. The challenge of comorbidity in clinical trials for multiple sclerosis. Neurology. 2016 Apr 12; 86(15):1437-1445. Marrie RA, Miller A, Sormani MP, Thompson A, Waubant E, Trojano M, O'Connor P, Reingold S, Cohen JA, attendees of the International Workshop on Comorbidity in Multiple Sclerosis. PMID: 26888986; PMCID: PMC4831041.
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    96. Recommendations for observational studies of comorbidity in multiple sclerosis. Neurology. 2016 Apr 12; 86(15):1446-1453. Marrie RA, Miller A, Sormani MP, Thompson A, Waubant E, Trojano M, O'Connor P, Fiest K, Reider N, Reingold S, Cohen JA, attendees of the International Workshop on Comorbidity in Multiple Sclerosis. PMID: 26865523; PMCID: PMC4831039.
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    97. Association Between Thoracic Spinal Cord Gray Matter Atrophy and Disability in Multiple Sclerosis. JAMA Neurol. 2015 Aug; 72(8):897-904. Schlaeger R, Papinutto N, Zhu AH, Lobach IV, Bevan CJ, Bucci M, Castellano A, Gelfand JM, Graves JS, Green AJ, Jordan KM, Keshavan A, Panara V, Stern WA, von Büdingen HC, Waubant E, Goodin DS, Cree BA, Hauser SL, Henry RG. PMID: 26053119; PMCID: PMC6002864.
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    98. Retinal damage and vision loss in African American multiple sclerosis patients. Ann Neurol. 2015 Feb; 77(2):228-36. Kimbrough DJ, Sotirchos ES, Wilson JA, Al-Louzi O, Conger A, Conger D, Frohman TC, Saidha S, Green AJ, Frohman EM, Balcer LJ, Calabresi PA. PMID: 25382184; PMCID: PMC4315746.
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    99. Encephalitis of unclear origin diagnosed by brain biopsy: a diagnostic challenge. JAMA Neurol. 2015 Jan; 72(1):66-72. Gelfand JM, Genrich G, Green AJ, Tihan T, Cree BA. PMID: 25365755.
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    100. The best basic science paper in MS in 2013: Antimuscarinic therapies in remyelination. Mult Scler. 2014 Dec; 20(14):1814-6. Green AJ. PMID: 25392329.
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    101. Precision medicine in chronic disease management: The multiple sclerosis BioScreen. Ann Neurol. 2014 Nov; 76(5):633-42. Gourraud PA, Henry RG, Cree BA, Crane JC, Lizee A, Olson MP, Santaniello AV, Datta E, Zhu AH, Bevan CJ, Gelfand JM, Graves JS, Goodin DS, Green AJ, von Büdingen HC, Waubant E, Zamvil SS, Crabtree-Hartman E, Nelson S, Baranzini SE, Hauser SL. PMID: 25263997; PMCID: PMC4214886.
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    102. Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD. J Exp Med. 2014 Sep 22; 211(10):1937-45. Ward ME, Taubes A, Chen R, Miller BL, Sephton CF, Gelfand JM, Minami S, Boscardin J, Martens LH, Seeley WW, Yu G, Herz J, Filiano AJ, Arrant AE, Roberson ED, Kraft TW, Farese RV, Green A, Gan L. PMID: 25155018; PMCID: PMC4172214.
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    103. Spinal cord gray matter atrophy correlates with multiple sclerosis disability. Ann Neurol. 2014 Oct; 76(4):568-80. Schlaeger R, Papinutto N, Panara V, Bevan C, Lobach IV, Bucci M, Caverzasi E, Gelfand JM, Green AJ, Jordan KM, Stern WA, von Büdingen HC, Waubant E, Zhu AH, Goodin DS, Cree BA, Hauser SL, Henry RG. PMID: 25087920; PMCID: PMC5316412.
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    104. Magnetic resonance imaging correlates of clinical outcomes in early multiple sclerosis. Mult Scler Relat Disord. 2014 Nov; 3(6):720-7. Maghzi AH, Revirajan N, Julian LJ, Spain R, Mowry EM, Liu S, Jin C, Green AJ, McCulloch CE, Pelletier D, Waubant E. PMID: 25891551.
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    105. Micropillar arrays as a high-throughput screening platform for therapeutics in multiple sclerosis. Nat Med. 2014 Aug; 20(8):954-960. Mei F, Fancy SPJ, Shen YA, Niu J, Zhao C, Presley B, Miao E, Lee S, Mayoral SR, Redmond SA, Etxeberria A, Xiao L, Franklin RJM, Green A, Hauser SL, Chan JR. PMID: 24997607; PMCID: PMC4830134.
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    106. Retinal architecture and mfERG: Optic nerve head component response characteristics in MS. Neurology. 2014 May 27; 82(21):1888-96. Schnurman ZS, Frohman TC, Beh SC, Conger D, Conger A, Saidha S, Galetta S, Calabresi PA, Green AJ, Balcer LJ, Frohman EM. PMID: 24789865; PMCID: PMC4105253.
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    107. Reply: Microcysts in the inner nuclear layer from optic atrophy are caused by retrograde trans-synaptic degeneration combined with vitreous traction on the retinal surface. Brain. 2013 Nov; 136(Pt 11):e261. Green AJ, Schwartz D, Gelfand J. PMID: 23872367.
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    108. Optic nerve head component responses of the multifocal electroretinogram in MS. Neurology. 2013 Aug 06; 81(6):545-51. Frohman TC, Beh SC, Saidha S, Schnurman Z, Conger D, Conger A, Ratchford JN, Lopez C, Galetta SL, Calabresi PA, Balcer LJ, Green AJ, Frohman EM. PMID: 23825172; PMCID: PMC3775685.
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    109. Microcystic inner nuclear layer abnormalities and neuromyelitis optica. JAMA Neurol. 2013 May; 70(5):629-33. Gelfand JM, Cree BA, Nolan R, Arnow S, Green AJ. PMID: 23529376.
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    110. Reply: Microcystic macular degeneration from optic neuropathy: not inflammatory, not trans-synaptic degeneration. Brain. 2013 Jul; 136(Pt 7):e240. Gelfand JM, Green AJ. PMID: 23650224; PMCID: PMC3692040.
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    111. Getting beyond the ganglion cell: morphometric adjustments for retinal optical coherence tomography in multiple sclerosis. JAMA Neurol. 2013 Jan; 70(1):13-5. Green AJ. PMID: 23318509.
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    112. Fingolimod treatment in multiple sclerosis leads to increased macular volume. Neurology. 2013 Jan 08; 80(2):139-44. Nolan R, Gelfand JM, Green AJ. PMID: 23223539; PMCID: PMC3589191.
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    113. Microcystic macular oedema, thickness of the inner nuclear layer of the retina, and disease characteristics in multiple sclerosis: a retrospective study. Lancet Neurol. 2012 Nov; 11(11):963-72. Saidha S, Sotirchos ES, Ibrahim MA, Crainiceanu CM, Gelfand JM, Sepah YJ, Ratchford JN, Oh J, Seigo MA, Newsome SD, Balcer LJ, Frohman EM, Green AJ, Nguyen QD, Calabresi PA. PMID: 23041237; PMCID: PMC3533139.
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    114. Retinal axonal loss begins early in the course of multiple sclerosis and is similar between progressive phenotypes. PLoS One. 2012; 7(5):e36847. Gelfand JM, Goodin DS, Boscardin WJ, Nolan R, Cuneo A, Green AJ. PMID: 22666330; PMCID: PMC3359324.
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    115. Microcystic macular oedema in multiple sclerosis is associated with disease severity. Brain. 2012 Jun; 135(Pt 6):1786-93. Gelfand JM, Nolan R, Schwartz DM, Graves J, Green AJ. PMID: 22539259; PMCID: PMC3359753.
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    116. Will the real optic nerve sheath please stand up? J Ultrasound Med. 2012 Jan; 31(1):130-1. Teismann NA, Lenaghan P, Stein J, Green A. PMID: 22215781.
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    117. Switching multiple sclerosis patients with breakthrough disease to second-line therapy. PLoS One. 2011 Feb 03; 6(2):e16664. Castillo-Trivino T, Mowry EM, Gajofatto A, Chabas D, Crabtree-Hartman E, Cree BA, Goodin DS, Green AJ, Okuda DT, Pelletier D, Zamvil SS, Vittinghoff E, Waubant E. PMID: 21304907; PMCID: PMC3033401.
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    118. Heterogeneous patterns of tissue injury in NARP syndrome. J Neurol. 2011 Mar; 258(3):440-8. Gelfand JM, Duncan JL, Racine CA, Gillum LA, Chin CT, Zhang Y, Zhang Q, Wong LJ, Roorda A, Green AJ. PMID: 20953793; PMCID: PMC3068520.
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    119. Optical coherence tomography: a sign of the times. Neurology. 2010 Oct 12; 75(15):1312-3. Green AJ. PMID: 20826713.
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    120. Optical coherence tomography in multiple sclerosis: a systematic review and meta-analysis. Lancet Neurol. 2010 Sep; 9(9):921-32. Petzold A, de Boer JF, Schippling S, Vermersch P, Kardon R, Green A, Calabresi PA, Polman C. PMID: 20723847.
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    121. Ocular pathology in multiple sclerosis: retinal atrophy and inflammation irrespective of disease duration. Brain. 2010 Jun; 133(Pt 6):1591-601. Green AJ, McQuaid S, Hauser SL, Allen IV, Lyness R. PMID: 20410146; PMCID: PMC2877904.
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    122. Understanding pseudo: the symptoms are real, the cause is unclear. Neurology. 2009 May 12; 72(19):1626-7. Green AJ. PMID: 19246422.
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    123. Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis. Hum Mol Genet. 2009 Feb 15; 18(4):767-78. Baranzini SE, Wang J, Gibson RA, Galwey N, Naegelin Y, Barkhof F, Radue EW, Lindberg RL, Uitdehaag BM, Johnson MR, Angelakopoulou A, Hall L, Richardson JC, Prinjha RK, Gass A, Geurts JJ, Kragt J, Sombekke M, Vrenken H, Qualley P, Lincoln RR, Gomez R, Caillier SJ, George MF, Mousavi H, Guerrero R, Okuda DT, Cree BA, Green AJ, Waubant E, Goodin DS, Pelletier D, Matthews PM, Hauser SL, Kappos L, Polman CH, Oksenberg JR. PMID: 19010793; PMCID: PMC4334814.
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    124. Pediatric multiple sclerosis. NeuroRx. 2006 Apr; 3(2):264-75. Chabas D, Green AJ, Waubant E. PMID: 16554264; PMCID: PMC3593440.
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    125. Progressive multifocal leukoencephalopathy in a patient treated with natalizumab. N Engl J Med. 2005 Jul 28; 353(4):375-81. Langer-Gould A, Atlas SW, Green AJ, Bollen AW, Pelletier D. PMID: 15947078.
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