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    Kathleen Liu, MD

    TitleAssociate Professor
    SchoolUCSF School of Medicine
    DepartmentMedicine
    Address521 Parnassus Avenue
    San Francisco CA 94143
    Phone415-502-7998

       Biography 
       Education and Training
      University of California, San FranciscoM.A.S. in Clinical Research Graduate Division (Advance Training in Clinical Research)2007
      University of California, San FranciscoM.D. Medicine1999
      University of California, San FranciscoPh.D. Graduate Division (Biochemistry)1997

       Overview 
       Overview
      EDUCATION

      College: Harvard University, AB
      Medical/Graduate School: University of California, San Francisco, MD, PhD

      RESEARCH

      My current research areas of interest focus on the predictive and pathogenetic role of biomarkers for both acute and chronic disease states. My long term goal is to identify and validate novel biomarkers of organ injury (specifically, the kidney and lung) that may have predictive value for disease outcomes as well as shed important insight into disease pathogenesis. In addition, I have a major interest in clinical trials in the Intensive Care Unit, with a particular focus on acute lung injury and acute kidney injury.


       ORNG Applications 
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       Bibliographic 
       Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Beitler JR, Thompson BT, Matthay MA, Talmor D, Liu KD, Zhuo H, Hayden D, Spragg RG, Malhotra A. Estimating dead-space fraction for secondary analyses of acute respiratory distress syndrome clinical trials. Crit Care Med. 2015 May; 43(5):1026-35.
        View in: PubMed
      2. Shieh SC, Liu KD. Finding the key to dialysis catheter lock. Am J Respir Crit Care Med. 2015 May 1; 191(9):972-4.
        View in: PubMed
      3. Wilson J, McKenna D, Liu KD, Matthay MA. Mesenchymal stem (stromal) cells for treatment of acute respiratory distress syndrome - Authors' reply. Lancet Respir Med. 2015 Apr; 3(4):e12-3.
        View in: PubMed
      4. Hsu CY, Ballard S, Batlle D, Bonventre JV, Böttinger EP, Feldman HI, Klein JB, Coresh J, Eckfeldt JH, Inker LA, Kimmel PL, Kusek JW, Liu KD, Mauer M, Mifflin TE, Molitch ME, Nelsestuen GL, Rebholz CM, Rovin BH, Sabbisetti VS, Van Eyk JE, Vasan RS, Waikar SS, Whitehead KM, Nelson RG. Cross-Disciplinary Biomarkers Research: Lessons Learned by the CKD Biomarkers Consortium. Clin J Am Soc Nephrol. 2015 May 7; 10(5):894-902.
        View in: PubMed
      5. Sapru A, Calfee CS, Liu KD, Kangelaris K, Hansen H, Pawlikowska L, Ware LB, Alkhouli MF, Abbott J, Matthay MA. Erratum to: Plasma soluble thrombomodulin levels are associated with mortality in the acute respiratory distress syndrome. Intensive Care Med. 2015 Mar; 41(3):574.
        View in: PubMed
      6. Ghannoum M, Wiegand TJ, Liu KD, Calello DP, Godin M, Lavergne V, Gosselin S, Nolin TD, Hoffman RS. Extracorporeal treatment for theophylline poisoning: Systematic review and recommendations from the EXTRIP workgroup. Clin Toxicol (Phila). 2015 May; 53(4):215-29.
        View in: PubMed
      7. Faubel S, Franch H, Vijayan A, Barron MA, Heung M, Liu KD, Koyner JL, Conner MJ. Preparing for renal replacement therapy in patients with the ebola virus disease. Blood Purif. 2014; 38(3-4):276-85.
        View in: PubMed
      8. Sapru A, Calfee CS, Liu KD, Kangelaris K, Hansen H, Pawlikowska L, Ware LB, Alkhouli MF, Abbot J, Matthay MA. Plasma soluble thrombomodulin levels are associated with mortality in the acute respiratory distress syndrome. Intensive Care Med. 2015 Mar; 41(3):470-8.
        View in: PubMed
      9. Grissom CK, Hirshberg EL, Dickerson JB, Brown SM, Lanspa MJ, Liu KD, Schoenfeld D, Tidswell M, Hite RD, Rock P, Miller RR, Morris AH. Fluid management with a simplified conservative protocol for the acute respiratory distress syndrome*. Crit Care Med. 2015 Feb; 43(2):288-95.
        View in: PubMed
      10. Schell-Chaple HM, Puntillo KA, Matthay MA, Liu KD. Body temperature and mortality in patients with acute respiratory distress syndrome. Am J Crit Care. 2015 Jan; 24(1):15-23.
        View in: PubMed
      11. Wilson JG, Liu KD, Zhuo H, Caballero L, McMillan M, Fang X, Cosgrove K, Vojnik R, Calfee CS, Lee JW, Rogers AJ, Levitt J, Wiener-Kronish J, Bajwa EK, Leavitt A, McKenna D, Thompson BT, Matthay MA. Mesenchymal stem (stromal) cells for treatment of ARDS: a phase 1 clinical trial. Lancet Respir Med. 2015 Jan; 3(1):24-32.
        View in: PubMed
      12. Fufaa GD, Weil EJ, Nelson RG, Hanson RL, Bonventre JV, Sabbisetti V, Waikar SS, Mifflin TE, Zhang X, Xie D, Hsu CY, Feldman HI, Coresh J, Vasan RS, Kimmel PL, Liu KD. Association of urinary KIM-1, L-FABP, NAG and NGAL with incident end-stage renal disease and mortality in American Indians with type 2 diabetes mellitus. Diabetologia. 2015 Jan; 58(1):188-98.
        View in: PubMed PMC4258130
      13. Liu KD, Yang W, Go AS, Anderson AH, Feldman HI, Fischer MJ, He J, Kallem RR, Kusek JW, Master SR, Miller ER, Rosas SE, Steigerwalt S, Tao K, Weir MR, Hsu CY. Urine Neutrophil Gelatinase-Associated Lipocalin and Risk of Cardiovascular Disease and Death in CKD: Results From the Chronic Renal Insufficiency Cohort (CRIC) Study. Am J Kidney Dis. 2015 Feb; 65(2):267-74.
        View in: PubMed
      14. Liu KD. Therapeutic strategies for clinical trials targeting renal recovery. Nephron Clin Pract. 2014; 127(1-4):113-6.
        View in: PubMed
      15. Liu KD, Dong N, Truwit JD. Rosuvastatin for sepsis-associated ARDS. N Engl J Med. 2014 Sep 4; 371(10):968-9.
        View in: PubMed
      16. Hsieh SJ, Zhuo H, Benowitz NL, Thompson BT, Liu KD, Matthay MA, Calfee CS. Prevalence and impact of active and passive cigarette smoking in acute respiratory distress syndrome. Crit Care Med. 2014 Sep; 42(9):2058-68.
        View in: PubMed PMC4134734
      17. Huddleston LL, Liu KD. Propofol as a panacea for acute kidney injury? Kidney Int. 2014 Aug; 86(2):240-3.
        View in: PubMed
      18. Krupa A, Fol M, Rahman M, Stokes KY, Florence JM, Leskov IL, Khoretonenko MV, Matthay MA, Liu KD, Calfee CS, Tvinnereim A, Rosenfield GR, Kurdowska AK. Silencing Bruton's tyrosine kinase in alveolar neutrophils protects mice from LPS/immune complex-induced acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2014 Sep 15; 307(6):L435-48.
        View in: PubMed PMC4166786
      19. Liu KD, Wilson JG, Zhuo H, Caballero L, McMillan ML, Fang X, Cosgrove K, Calfee CS, Lee JW, Kangelaris KN, Gotts JE, Rogers AJ, Levitt JE, Wiener-Kronish JP, Delucchi KL, Leavitt AD, McKenna DH, Thompson BT, Matthay MA. Design and implementation of the START (STem cells for ARDS Treatment) trial, a phase 1/2 trial of human mesenchymal stem/stromal cells for the treatment of moderate-severe acute respiratory distress syndrome. Ann Intensive Care. 2014; 4:22.
        View in: PubMed
      20. Moseson EM, Zhuo H, Chu J, Stein JC, Matthay MA, Kangelaris KN, Liu KD, Calfee CS. Intensive care unit scoring systems outperform emergency department scoring systems for mortality prediction in critically ill patients: a prospective cohort study. J Intensive Care. 2014; 2:40.
        View in: PubMed
      21. Asmussen S, Ito H, Traber DL, Lee JW, Cox RA, Hawkins HK, McAuley DF, McKenna DH, Traber LD, Zhuo H, Wilson J, Herndon DN, Prough DS, Liu KD, Matthay MA, Enkhbaatar P. Human mesenchymal stem cells reduce the severity of acute lung injury in a sheep model of bacterial pneumonia. Thorax. 2014 Sep; 69(9):819-25.
        View in: PubMed
      22. Orme RM, Perkins GD, McAuley DF, Liu KD, Mason AJ, Morelli A, Singer M, Ashby D, Gordon AC. An efficacy and mechanism evaluation study of Levosimendan for the Prevention of Acute oRgan Dysfunction in Sepsis (LeoPARDS): protocol for a randomized controlled trial. Trials. 2014; 15:199.
        View in: PubMed PMC4061524
      23. Rosuvastatin for sepsis-associated acute respiratory distress syndrome. N Engl J Med. 2014 Jun 5; 370(23):2191-200.
        View in: PubMed
      24. Koyner JL, Cerdá J, Goldstein SL, Jaber BL, Liu KD, Shea JA, Faubel S. The daily burden of acute kidney injury: a survey of U.S. nephrologists on World Kidney Day. Am J Kidney Dis. 2014 Sep; 64(3):394-401.
        View in: PubMed
      25. Wong HR, Liu KD, Kangelaris KN, Lahni P, Calfee CS. Performance of interleukin-27 as a sepsis diagnostic biomarker in critically ill adults. J Crit Care. 2014 Oct; 29(5):718-22.
        View in: PubMed PMC4141017
      26. Hsu CY, Liu KD. Cardiovascular events after AKI: a new dimension. J Am Soc Nephrol. 2014 Mar; 25(3):425-7.
        View in: PubMed PMC3935600
      27. Asija R, Roth SJ, Hanley FL, Peng L, Liu K, Abbott J, Zhuo H, Matthay M. Reperfusion pulmonary edema in children with tetralogy of Fallot, pulmonary atresia, and major aortopulmonary collateral arteries undergoing unifocalization procedures: A pilot study examining potential pathophysiologic mechanisms and clinical significance. J Thorac Cardiovasc Surg. 2014 Oct; 148(4):1560-5.
        View in: PubMed
      28. Kwon SH, Liu KD, Mostov KE. Intercellular transfer of GPRC5B via exosomes drives HGF-mediated outward growth. Curr Biol. 2014 Jan 20; 24(2):199-204.
        View in: PubMed PMC3938203
      29. Kallet RH, Zhuo H, Liu KD, Calfee CS, Matthay MA. The Association Between Physiologic Dead-Space Fraction and Mortality in Subjects With ARDS Enrolled in a Prospective Multi-Center Clinical Trial. Respir Care. 2014 Nov; 59(11):1611-8.
        View in: PubMed PMC4077995
      30. Wilson JG, Butcher BW, Liu KD. Evolving practices in critical care and their influence on acute kidney injury. Curr Opin Crit Care. 2013 Dec; 19(6):523-30.
        View in: PubMed
      31. Parikh CR, Butrymowicz I, Yu A, Chinchilli VM, Park M, Hsu CY, Reeves WB, Devarajan P, Kimmel PL, Siew ED, Liu KD. Urine stability studies for novel biomarkers of acute kidney injury. Am J Kidney Dis. 2014 Apr; 63(4):567-72.
        View in: PubMed PMC3969397
      32. Bonventre JV, Basile D, Liu KD, McKay D, Molitoris BA, Nath KA, Nickolas TL, Okusa MD, Palevsky PM, Schnellmann R, Rys-Sikora K, Kimmel PL, Star RA. AKI: a path forward. Clin J Am Soc Nephrol. 2013 Sep; 8(9):1606-8.
        View in: PubMed PMC3805072
      33. Liu KD, Yang W, Hsu CY. The authors reply. Kidney Int. 2013 Jul; 84(1):217.
        View in: PubMed
      34. Lameire NH, Bagga A, Cruz D, De Maeseneer J, Endre Z, Kellum JA, Liu KD, Mehta RL, Pannu N, Van Biesen W, Vanholder R. Acute kidney injury: an increasing global concern. Lancet. 2013 Jul 13; 382(9887):170-9.
        View in: PubMed
      35. Agrawal A, Matthay MA, Kangelaris KN, Stein J, Chu JC, Imp BM, Cortez A, Abbott J, Liu KD, Calfee CS. Plasma angiopoietin-2 predicts the onset of acute lung injury in critically ill patients. Am J Respir Crit Care Med. 2013 Apr 1; 187(7):736-42.
        View in: PubMed PMC3678110
      36. Palevsky PM, Liu KD, Brophy PD, Chawla LS, Parikh CR, Thakar CV, Tolwani AJ, Waikar SS, Weisbord SD. KDOQI US commentary on the 2012 KDIGO clinical practice guideline for acute kidney injury. Am J Kidney Dis. 2013 May; 61(5):649-72.
        View in: PubMed
      37. Park M, Vittinghoff E, Liu KD, Shlipak MG, Hsu CY. Urine Biomarkers Neutrophil Gelatinase-Associated Lipocalin (NGAL) and Kidney Injury Molecule-1 (KIM-1) Have Different Patterns in Heart Failure Exacerbation. Biomark Insights. 2013; 8:15-8.
        View in: PubMed PMC3603387
      38. Liu KD, Yang W, Anderson AH, Feldman HI, Demirjian S, Hamano T, He J, Lash J, Lustigova E, Rosas SE, Simonson MS, Tao K, Hsu CY. Urine neutrophil gelatinase-associated lipocalin levels do not improve risk prediction of progressive chronic kidney disease. Kidney Int. 2013 May; 83(5):909-14.
        View in: PubMed PMC3642209
      39. Liu KD. Critical care nephrology: update in critical care for the nephrologist. Adv Chronic Kidney Dis. 2013 Jan; 20(1):4-5.
        View in: PubMed
      40. Butcher BW, Liu KD. Fluid overload in AKI: epiphenomenon or putative effect on mortality? Curr Opin Crit Care. 2012 Dec; 18(6):593-8.
        View in: PubMed PMC3782260
      41. Agrawal A, Zhuo H, Brady S, Levitt J, Steingrub J, Siegel MD, Soto G, Peterson MW, Chesnutt MS, Matthay MA, Liu KD. Pathogenetic and predictive value of biomarkers in patients with ALI and lower severity of illness: results from two clinical trials. Am J Physiol Lung Cell Mol Physiol. 2012 Oct 15; 303(8):L634-9.
        View in: PubMed PMC3469636
      42. Ghannoum M, Nolin TD, Goldfarb DS, Roberts DM, Mactier R, Mowry JB, Dargan PI, Maclaren R, Hoegberg LC, Laliberté M, Calello D, Kielstein JT, Anseeuw K, Winchester JF, Burdmann EA, Bunchman TE, Li Y, Juurlink DN, Lavergne V, Megarbane B, Gosselin S, Liu KD, Hoffman RS. Extracorporeal treatment for thallium poisoning: recommendations from the EXTRIP Workgroup. Clin J Am Soc Nephrol. 2012 Oct; 7(10):1682-90.
        View in: PubMed
      43. Lavergne V, Nolin TD, Hoffman RS, Roberts D, Gosselin S, Goldfarb DS, Kielstein JT, Mactier R, Maclaren R, Mowry JB, Bunchman TE, Juurlink D, Megarbane B, Anseeuw K, Winchester JF, Dargan PI, Liu KD, Hoegberg LC, Li Y, Calello DP, Burdmann EA, Yates C, Laliberté M, Decker BS, Mello-Da-Silva CA, Lavonas E, Ghannoum M. The EXTRIP (EXtracorporeal TReatments In Poisoning) workgroup: guideline methodology. Clin Toxicol (Phila). 2012 Jun; 50(5):403-13.
        View in: PubMed
      44. Palevsky PM, Molitoris BA, Okusa MD, Levin A, Waikar SS, Wald R, Chertow GM, Murray PT, Parikh CR, Shaw AD, Go AS, Faubel SG, Kellum JA, Chinchilli VM, Liu KD, Cheung AK, Weisbord SD, Chawla LS, Kaufman JS, Devarajan P, Toto RM, Hsu CY, Greene T, Mehta RL, Stokes JB, Thompson AM, Thompson BT, Westenfelder CS, Tumlin JA, Warnock DG, Shah SV, Xie Y, Duggan EG, Kimmel PL, Star RA. Design of clinical trials in acute kidney injury: report from an NIDDK workshop on trial methodology. Clin J Am Soc Nephrol. 2012 May; 7(5):844-50.
        View in: PubMed
      45. Faubel S, Chawla LS, Chertow GM, Goldstein SL, Jaber BL, Liu KD. Ongoing clinical trials in AKI. Clin J Am Soc Nephrol. 2012 May; 7(5):861-73.
        View in: PubMed
      46. Molitoris BA, Okusa MD, Palevsky PM, Chawla LS, Kaufman JS, Devarajan P, Toto RM, Hsu CY, Greene TH, Faubel SG, Kellum JA, Wald R, Chertow GM, Levin A, Waikar SS, Murray PT, Parikh CR, Shaw AD, Go AS, Chinchilli VM, Liu KD, Cheung AK, Weisbord SD, Mehta RL, Stokes JB, Thompson AM, Thompson BT, Westenfelder CS, Tumlin JA, Warnock DG, Shah SV, Xie Y, Duggan EG, Kimmel PL, Star RA. Design of clinical trials in AKI: a report from an NIDDK workshop. Trials of patients with sepsis and in selected hospital settings. Clin J Am Soc Nephrol. 2012 May; 7(5):856-60.
        View in: PubMed
      47. Okusa MD, Molitoris BA, Palevsky PM, Chinchilli VM, Liu KD, Cheung AK, Weisbord SD, Faubel S, Kellum JA, Wald R, Chertow GM, Levin A, Waikar SS, Murray PT, Parikh CR, Shaw AD, Go AS, Chawla LS, Kaufman JS, Devarajan P, Toto RM, Hsu CY, Greene TH, Mehta RL, Stokes JB, Thompson AM, Thompson BT, Westenfelder CS, Tumlin JA, Warnock DG, Shah SV, Xie Y, Duggan EG, Kimmel PL, Star RA. Design of clinical trials in acute kidney injury: a report from an NIDDK workshop--prevention trials. Clin J Am Soc Nephrol. 2012 May; 7(5):851-5.
        View in: PubMed
      48. Kangelaris KN, Sapru A, Calfee CS, Liu KD, Pawlikowska L, Witte JS, Vittinghoff E, Zhuo H, Auerbach AD, Ziv E, Matthay MA. The association between a Darc gene polymorphism and clinical outcomes in African American patients with acute lung injury. Chest. 2012 May; 141(5):1160-9.
        View in: PubMed PMC3342784
      49. Liu KD, Thompson BT, Ancukiewicz M, Steingrub JS, Douglas IS, Matthay MA, Wright P, Peterson MW, Rock P, Hyzy RC, Anzueto A, Truwit JD. Acute kidney injury in patients with acute lung injury: impact of fluid accumulation on classification of acute kidney injury and associated outcomes. Crit Care Med. 2011 Dec; 39(12):2665-71.
        View in: PubMed PMC3220741
      50. Britos M, Smoot E, Liu KD, Thompson BT, Checkley W, Brower RG. The value of positive end-expiratory pressure and Fio2 criteria in the definition of the acute respiratory distress syndrome. Crit Care Med. 2011 Sep; 39(9):2025-30.
        View in: PubMed PMC3157575
      51. Randomized, placebo-controlled clinical trial of an aerosolized ß2-agonist for treatment of acute lung injury. Am J Respir Crit Care Med. 2011 Sep 1; 184(5):561-8.
        View in: PubMed PMC3175548
      52. Zhang M, Hsu R, Hsu CY, Kordesch K, Nicasio E, Cortez A, McAlpine I, Brady S, Zhuo H, Kangelaris KN, Stein J, Calfee CS, Liu KD. FGF-23 and PTH levels in patients with acute kidney injury: A cross-sectional case series study. Ann Intensive Care. 2011; 1(1):21.
        View in: PubMed PMC3224491
      53. Cepkova M, Kapur V, Ren X, Quinn T, Zhuo H, Foster E, Matthay MA, Liu KD. Clinical significance of elevated B-type natriuretic peptide in patients with acute lung injury with or without right ventricular dilatation: an observational cohort study. Ann Intensive Care. 2011; 1(1):18.
        View in: PubMed PMC3224453
      54. Flori HR, Church G, Liu KD, Gildengorin G, Matthay MA. Positive fluid balance is associated with higher mortality and prolonged mechanical ventilation in pediatric patients with acute lung injury. Crit Care Res Pract. 2011; 2011:854142.
        View in: PubMed PMC3114079
      55. Matthay MA, Liu KD. Con: corticosteroids are not indicated for treatment of acute lung injury from H1N1 viral pneumonia. Am J Respir Crit Care Med. 2011 May 1; 183(9):1127-8.
        View in: PubMed PMC3114049
      56. Grams ME, Estrella MM, Coresh J, Brower RG, Liu KD. Fluid balance, diuretic use, and mortality in acute kidney injury. Clin J Am Soc Nephrol. 2011 May; 6(5):966-73.
        View in: PubMed PMC3087792
      57. Sapru A, Pawlikowska L, Liu KD, Khush KK, Ann-Baxter-Lowe L, Hayden V, Menza RL, Convery M, Poon A, Landeck M, Zaroff JG, Matthay MA. Single-nucleotide polymorphisms in the ß-adrenergic receptor genes are associated with lung allograft utilization. J Heart Lung Transplant. 2011 Feb; 30(2):211-7.
        View in: PubMed PMC3019270
      58. Liu KD, Chertow GM. Curbing the use of ultrasonography in the diagnosis of acute kidney injury: Penny wise or pound foolish?: Comment on "Renal ultrasonography in the evaluation of acute kidney injury". Arch Intern Med. 2010 Nov 22; 170(21):1907-8.
        View in: PubMed PMC4095784
      59. Matthay MA, Thompson BT, Read EJ, McKenna DH, Liu KD, Calfee CS, Lee JW. Therapeutic potential of mesenchymal stem cells for severe acute lung injury. Chest. 2010 Oct; 138(4):965-72.
        View in: PubMed PMC2951759
      60. Ong T, McClintock DE, Kallet RH, Ware LB, Matthay MA, Liu KD. Ratio of angiopoietin-2 to angiopoietin-1 as a predictor of mortality in acute lung injury patients. Crit Care Med. 2010 Sep; 38(9):1845-51.
        View in: PubMed PMC4009623
      61. Go AS, Parikh CR, Ikizler TA, Coca S, Siew ED, Chinchilli VM, Hsu CY, Garg AX, Zappitelli M, Liu KD, Reeves WB, Ghahramani N, Devarajan P, Faulkner GB, Tan TC, Kimmel PL, Eggers P, Stokes JB. The assessment, serial evaluation, and subsequent sequelae of acute kidney injury (ASSESS-AKI) study: design and methods. BMC Nephrol. 2010; 11:22.
        View in: PubMed PMC2944247
      62. Liu KD. Acute kidney injury: is acute kidney injury a risk factor for long-term mortality? Nat Rev Nephrol. 2010 Jul; 6(7):389-91.
        View in: PubMed
      63. Johnson XD, Liu KD. Acute renal syndrome/renal angina: a new paradigm for studies of acute kidney injury? Clin J Am Soc Nephrol. 2010 May; 5(5):753-5.
        View in: PubMed
      64. Liu KD, Glidden DV. Clinical trials for acute kidney injury: design challenges and possible solutions. Curr Drug Targets. 2009 Dec; 10(12):1190-5.
        View in: PubMed
      65. Brown LM, Liu KD, Matthay MA. Measurement of extravascular lung water using the single indicator method in patients: research and potential clinical value. Am J Physiol Lung Cell Mol Physiol. 2009 Oct; 297(4):L547-58.
        View in: PubMed PMC2770794
      66. Liu KD, Altmann C, Smits G, Krawczeski CD, Edelstein CL, Devarajan P, Faubel S. Serum interleukin-6 and interleukin-8 are early biomarkers of acute kidney injury and predict prolonged mechanical ventilation in children undergoing cardiac surgery: a case-control study. Crit Care. 2009; 13(4):R104.
        View in: PubMed PMC2750143
      67. Liu KD, Looney MR, Matthay MA. Inhaled activated protein C: a novel therapy for acute lung injury? Crit Care. 2009; 13(3):150.
        View in: PubMed PMC2717421
      68. Neyrinck AP, Liu KD, Howard JP, Matthay MA. Protective mechanisms of activated protein C in severe inflammatory disorders. Br J Pharmacol. 2009 Oct; 158(4):1034-47.
        View in: PubMed PMC2785525
      69. Church GD, Matthay MA, Liu K, Milet M, Flori HR. Blood product transfusions and clinical outcomes in pediatric patients with acute lung injury. Pediatr Crit Care Med. 2009 May; 10(3):297-302.
        View in: PubMed PMC3586190
      70. Liu KD, Lo L, Hsu CY. Some methodological issues in studying the long-term renal sequelae of acute kidney injury. Curr Opin Nephrol Hypertens. 2009 May; 18(3):241-5.
        View in: PubMed
      71. Ong T, Stuart-Killion RB, Daniel BM, Presnell LB, Zhuo H, Matthay MA, Liu KD. Higher pulmonary dead space may predict prolonged mechanical ventilation after cardiac surgery. Pediatr Pulmonol. 2009 May; 44(5):457-63.
        View in: PubMed PMC2768264
      72. Lo L, Liu KD, Hsu CY. Long-term outcomes after acute kidney injury: where we stand and how we can move forward. Am J Kidney Dis. 2009 Jun; 53(6):928-31.
        View in: PubMed
      73. Liu KD. Critical care nephrology: Core Curriculum 2009. Am J Kidney Dis. 2009 May; 53(5):898-910.
        View in: PubMed PMC2697970
      74. Brakeman PR, Liu KD, Shimizu K, Takai Y, Mostov KE. Nectin proteins are expressed at early stages of nephrogenesis and play a role in renal epithelial cell morphogenesis. Am J Physiol Renal Physiol. 2009 Mar; 296(3):F564-74.
        View in: PubMed PMC2660185
      75. Liu KD. Impact of acute kidney injury on lung injury. Am J Physiol Lung Cell Mol Physiol. 2009 Jan; 296(1):L1-2.
        View in: PubMed
      76. Liu KD, Levitt J, Zhuo H, Kallet RH, Brady S, Steingrub J, Tidswell M, Siegel MD, Soto G, Peterson MW, Chesnutt MS, Phillips C, Weinacker A, Thompson BT, Eisner MD, Matthay MA. Randomized clinical trial of activated protein C for the treatment of acute lung injury. Am J Respir Crit Care Med. 2008 Sep 15; 178(6):618-23.
        View in: PubMed PMC2542435
      77. Liu KD, Matthay MA. Protein C as a surrogate end-point for clinical trials of sepsis. Crit Care. 2008; 12(2):139.
        View in: PubMed PMC2447596
      78. Liu KD, Brakeman PR. Renal repair and recovery. Crit Care Med. 2008 Apr; 36(4 Suppl):S187-92.
        View in: PubMed
      79. Lindemann MJ, Hu Z, Benczik M, Liu KD, Gaffen SL. Differential regulation of the IL-17 receptor by gammac cytokines: inhibitory signaling by the phosphatidylinositol 3-kinase pathway. J Biol Chem. 2008 May 16; 283(20):14100-8.
        View in: PubMed PMC2376247
      80. Waikar SS, Liu KD, Chertow GM. Diagnosis, epidemiology and outcomes of acute kidney injury. Clin J Am Soc Nephrol. 2008 May; 3(3):844-61.
        View in: PubMed
      81. Liu KD, Matthay MA. Advances in critical care for the nephrologist: acute lung injury/ARDS. Clin J Am Soc Nephrol. 2008 Mar; 3(2):578-86.
        View in: PubMed
      82. Liu KD, Glidden DV, Eisner MD, Parsons PE, Ware LB, Wheeler A, Korpak A, Thompson BT, Chertow GM, Matthay MA. Predictive and pathogenetic value of plasma biomarkers for acute kidney injury in patients with acute lung injury. Crit Care Med. 2007 Dec; 35(12):2755-61.
        View in: PubMed PMC3293249
      83. Liu KD, Datta A, Yu W, Brakeman PR, Jou TS, Matthay MA, Mostov KE. Rac1 is required for reorientation of polarity and lumen formation through a PI 3-kinase-dependent pathway. Am J Physiol Renal Physiol. 2007 Nov; 293(5):F1633-40.
        View in: PubMed
      84. Cepkova M, Kapur V, Ren X, Quinn T, Zhuo H, Foster E, Liu KD, Matthay MA. Pulmonary dead space fraction and pulmonary artery systolic pressure as early predictors of clinical outcome in acute lung injury. Chest. 2007 Sep; 132(3):836-42.
        View in: PubMed
      85. Waikar SS, Liu KD, Chertow GM. The incidence and prognostic significance of acute kidney injury. Curr Opin Nephrol Hypertens. 2007 May; 16(3):227-36.
        View in: PubMed PMC3027554
      86. Liu KD, Himmelfarb J, Paganini E, Ikizler TA, Soroko SH, Mehta RL, Chertow GM. Timing of initiation of dialysis in critically ill patients with acute kidney injury. Clin J Am Soc Nephrol. 2006 Sep; 1(5):915-9.
        View in: PubMed
      87. Liu KD, Matthay MA, Chertow GM. Evolving practices in critical care and potential implications for management of acute kidney injury. Clin J Am Soc Nephrol. 2006 Jul; 1(4):869-73.
        View in: PubMed
      88. Mostov K, Brakeman P, Datta A, Gassama A, Katz L, Kim M, Leroy P, Levin M, Liu K, Martin F, O'Brien LE, Verges M, Su T, Tang K, Tanimizu N, Yamaji T, Yu W. Formation of multicellular epithelial structures. Novartis Found Symp. 2005; 269:193-200; discussion 200-5, 223-30.
        View in: PubMed
      89. Gaffen SL, Liu KD. Overview of interleukin-2 function, production and clinical applications. Cytokine. 2004 Nov 7; 28(3):109-23.
        View in: PubMed
      90. Kallet RH, Liu K, Tang J. Management of acidosis during lung-protective ventilation in acute respiratory distress syndrome. Respir Care Clin N Am. 2003 Dec; 9(4):437-56.
        View in: PubMed
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