David Solomon, MD, PhD
|School||UCSF School of Medicine|
|Address||513 Parnassus Ave|
San Francisco CA 94143
|College of William and Mary||B.S. Molecular Cell Biology, Chemistry||2002|
|Georgetown University School of Medicine||M.D., Ph.D. Tumor Biology||2012|
|University of California, San Francisco||Residency in Anatomic Pathology||2015|
|University of California, San Francisco||Fellowship in Neuropathology||2016|
|NIH Director's Early Independence Award||2015
||2020||High-Risk, High-Reward Research Program supported by the NIH Common Fund|
|Harold M. Weintraub Graduate Student Award||2012||one of twelve recipients at the Weintraub Symposium, Fred Hutchinson Cancer Research Center, Seattle|
|Future Leaders in Basic Cancer Research||2012||one of four recipients at the 2012 American Association for Cancer Research Annual Meeting, Chicago|
|Career Development Research Award||2015
||2016||UCSF Brain Tumor SPORE|
|Stowell-Orbison Award||2014||best abstract presentation by a trainee at Annual Meeting of the US & Canada Academy of Pathology|
|Young Investigator Award||2014||best abstract presentation by a trainee, International Society of Bone and Soft Tissue Pathology|
|Stowell-Orbison Award||2013||best abstract presentation by a trainee at Annual Meeting of the US & Canada Academy of Pathology|
|Julius Krevans Award||2013||outstanding clinical service by a UCSF Pathology Intern, San Francisco General Hospital|
|Clifford C. Kaslow Research Achievement Award||2011||Department of Medicine, Georgetown University Medical Center (2008 and 2011)|
|Robert Dickson Graduate Prize||2011||recipient of inaugural award, Lombardi Cancer Center, Georgetown University Medical Center|
|Strauss Physician Scientist Training Fellowship||2004
||2012||Georgetown University School of Medicine|
|Howard Hughes Medical Institute student research grants||2000
||2002||College of William and Mary Undergraduate Science Education and Research Program|
|William and Mary Monroe Scholar||1998
||2002||College of William and Mary, Williamsburg, VA|
|National Merit Scholar||1998|
I am a neuropathologist and cancer researcher at the University of California, San Francisco with a dedicated interest in the genetic alterations that drive cancer development. We have recently discovered frequent inactivating mutations of the cohesin complex gene STAG2 in glioblastoma, urothelial bladder cancer, Ewing sarcoma, and acute myeloid leukemia (AML), which define molecular subgroups of these tumors with distinct clinical outcomes. The cohesin complex is responsible for sister chromatid cohesion following DNA replication and helps ensure faithful chromosome segregation during mitosis, but has also been implicated in additional cellular processes such as regulation of chromatin architecture and gene transcription. Our studies in glioblastoma demonstrated that STAG2 mutations were a direct cause of chromosomal instability and aneuploidy; however, cohesin gene alterations in urothelial carcinoma and AML have been identified primarily in near-diploid tumors, suggesting alternative mechanisms by which cohesin inactivation drives oncogenesis. Using a newly generated conditional STAG2 knockout mouse and isogenic sets of STAG2 proficient and deficient cancer cell lines, we are currently working to determine the function of STAG2 in mouse development and tumorigenesis and to identify therapeutic vulnerabilities in the many cancers harboring cohesin gene alterations. Other ongoing studies in the Solomon Lab include genomic characterization of brain tumor variants such as chordoid gliomas, choroid plexus tumors, and pineal parenchymal tumors.
cohesin, sister chromatid cohesion, STAG2, aneuploidy, chromosomal instability, cancer genetics, genetic pathways in tumorigenesis, molecular diagnostics, next-generation sequencing, glioblastoma, glioma, astrocytoma, oligodendroglioma, neurocytoma, choroid plexus neoplasms, pineal parenchymal tumors, pineoblastoma, PPTID, brain tumors, Ewing sarcoma, urothelial carcinoma, bladder cancer, Langerhans cell histiocytosis, surgical pathology, neuropathology, molecular pathology
Derived automatically from this person's publications.
People in Profiles who have published with this person.
People who share related concepts with this person.