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    David Solomon, MD, PhD

    TitleAssistant Professor
    SchoolUCSF School of Medicine
    Address513 Parnassus Ave
    San Francisco CA 94143
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      Collapse Biography 
      Collapse Education and Training
      College of William and MaryB.S. Molecular Cell Biology, Chemistry2002
      Georgetown University School of MedicineM.D., Ph.D. Tumor Biology2012
      University of California, San FranciscoResidency in Anatomic Pathology2015
      University of California, San FranciscoFellowship in Neuropathology2016
      Collapse Awards and Honors
      NIH Director's Early Independence Award2015 - 2020High-Risk, High-Reward Research Program supported by the NIH Common Fund
      Harold M. Weintraub Graduate Student Award2012one of twelve recipients at the Weintraub Symposium, Fred Hutchinson Cancer Research Center, Seattle
      Future Leaders in Basic Cancer Research2012one of four recipients at the 2012 American Association for Cancer Research Annual Meeting, Chicago
      Career Development Research Award2015 - 2016UCSF Brain Tumor SPORE
      Stowell-Orbison Award2014best abstract presentation by a trainee at Annual Meeting of the US & Canada Academy of Pathology
      Young Investigator Award2014best abstract presentation by a trainee, International Society of Bone and Soft Tissue Pathology
      Stowell-Orbison Award2013best abstract presentation by a trainee at Annual Meeting of the US & Canada Academy of Pathology
      Julius Krevans Award2013outstanding clinical service by a UCSF Pathology Intern, San Francisco General Hospital
      Clifford C. Kaslow Research Achievement Award2011Department of Medicine, Georgetown University Medical Center (2008 and 2011)
      Robert Dickson Graduate Prize2011recipient of inaugural award, Lombardi Cancer Center, Georgetown University Medical Center
      Strauss Physician Scientist Training Fellowship2004 - 2012Georgetown University School of Medicine
      Howard Hughes Medical Institute student research grants2000 - 2002College of William and Mary Undergraduate Science Education and Research Program
      William and Mary Monroe Scholar1998 - 2002College of William and Mary, Williamsburg, VA
      National Merit Scholar1998

      Collapse Overview 
      Collapse Overview
      I am a neuropathologist and cancer researcher at the University of California, San Francisco with a dedicated interest in the genetic alterations that drive cancer development. We have recently discovered frequent inactivating mutations of the cohesin complex gene STAG2 in glioblastoma, urothelial bladder cancer, Ewing sarcoma, and acute myeloid leukemia (AML), which define molecular subgroups of these tumors with distinct clinical outcomes. The cohesin complex is responsible for sister chromatid cohesion following DNA replication and helps ensure faithful chromosome segregation during mitosis, but has also been implicated in additional cellular processes such as regulation of chromatin architecture and gene transcription. Our studies in glioblastoma demonstrated that STAG2 mutations were a direct cause of chromosomal instability and aneuploidy; however, cohesin gene alterations in urothelial carcinoma and AML have been identified primarily in near-diploid tumors, suggesting alternative mechanisms by which cohesin inactivation drives oncogenesis. Using a newly generated conditional STAG2 knockout mouse and isogenic sets of STAG2 proficient and deficient cancer cell lines, we are currently working to determine the function of STAG2 in mouse development and tumorigenesis and to identify therapeutic vulnerabilities in the many cancers harboring cohesin gene alterations. Other ongoing studies in the Solomon Lab include genomic characterization of brain tumor variants such as chordoid gliomas, choroid plexus tumors, and pineal parenchymal tumors.

      Collapse Interests
      cohesin, sister chromatid cohesion, STAG2, aneuploidy, chromosomal instability, cancer genetics, genetic pathways in tumorigenesis, molecular diagnostics, next-generation sequencing, glioblastoma, glioma, astrocytoma, oligodendroglioma, neurocytoma, choroid plexus neoplasms, pineal parenchymal tumors, pineoblastoma, PPTID, brain tumors, Ewing sarcoma, urothelial carcinoma, bladder cancer, Langerhans cell histiocytosis, surgical pathology, neuropathology, molecular pathology

      Collapse ORNG Applications 
      Collapse Websites
      Collapse In The News
      Collapse Featured Publications

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Joseph NM, Chen YY, Nasr A, Yeh I, Talevich E, Onodera C, Bastian BC, Rabban JT, Garg K, Zaloudek C, Solomon DA. Genomic profiling of malignant peritoneal mesothelioma reveals recurrent alterations in epigenetic regulatory genes BAP1, SETD2, and DDX3X. Mod Pathol. 2016 Nov 04. PMID: 27813512.
        View in: PubMed
      2. Phillips JJ, Gong H, Chen K, Joseph NM, van Ziffle J, Jin LW, Bastian BC, Bollen AW, Perry A, Nicolaides T, Solomon DA, Shieh JT, et al. Activating NRF1-BRAF and ATG7-RAF1 fusions in anaplastic pleomorphic xanthoastrocytoma without BRAF p.V600E mutation. Acta Neuropathol. 2016 Sep 13. PMID: 27624885.
        View in: PubMed
      3. Cohen JN, Solomon DA, Horvai AE, Kakar S, et al. Pancreatic Involvement by Mesenchymal Chondrosarcoma Harboring the HEY1-NCOA2 Gene Fusion. Hum Pathol. 2016 Aug 17. PMID: 27544802.
        View in: PubMed
      4. Hale G, Liu X, Hu J, Xu Z, Che L, Solomon D, Tsokos C, Shafizadeh N, Chen X, Gill R, Kakar S, et al. Correlation of exon 3 ß-catenin mutations with glutamine synthetase staining patterns in hepatocellular adenoma and hepatocellular carcinoma. Mod Pathol. 2016 Jul 29. PMID: 27469330.
        View in: PubMed
      5. Raleigh DR, Solomon DA, Lloyd SA, Lazar A, Garcia MA, Sneed PK, Clarke JL, McDermott MW, Berger MS, Tihan T, Haas-Kogan DA, et al. Histopathologic review of pineal parenchymal tumors identifies novel morphologic subtypes and prognostic factors for outcome. Neuro Oncol. 2016 Jun 9. PMID: 27282397.
        View in: PubMed
      6. Ferris SP, Goode B, Joseph NM, Kline CN, Samuel D, Gupta N, Bollen A, Perry A, Mueller S, Solomon DA. IDH1 mutation can be present in diffuse astrocytomas and giant cell glioblastomas of young children under 10 years of age. Acta Neuropathol. 2016 Jul; 132(1):153-5. PMID: 27161253.
        View in: PubMed
      7. Garcia MA, Solomon DA, Haas-Kogan DA. Exploiting molecular biology for diagnosis and targeted management of pediatric low-grade gliomas. Future Oncol. 2016 Jun; 12(12):1493-506. PMID: 27072750.
        View in: PubMed
      8. Kline CN, Joseph NM, Grenert JP, van Ziffle J, Yeh I, Bastian BC, Mueller S, Solomon DA. Inactivating MUTYH germline mutations in pediatric patients with high-grade midline gliomas. Neuro Oncol. 2016 May; 18(5):752-3. PMID: 26902849.
        View in: PubMed
      9. Joseph NM, Solomon DA, Frizzell N, Rabban JT, Zaloudek C, Garg K. Morphology and Immunohistochemistry for 2SC and FH Aid in Detection of Fumarate Hydratase Gene Aberrations in Uterine Leiomyomas From Young Patients. Am J Surg Pathol. 2015 Nov; 39(11):1529-39. PMID: 26457356.
        View in: PubMed
      10. Solomon DA, Wood MD, Tihan T, Bollen AW, Gupta N, Phillips JJ, Perry A. Diffuse Midline Gliomas with Histone H3-K27M Mutation: A Series of 47 Cases Assessing the Spectrum of Morphologic Variation and Associated Genetic Alterations. Brain Pathol. 2015 Oct 30. PMID: 26517431.
        View in: PubMed
      11. Mabray MC, Glastonbury CM, Mamlouk MD, Punch GE, Solomon DA, Cha S. Direct Cranial Nerve Involvement by Gliomas: Case Series and Review of the Literature. AJNR Am J Neuroradiol. 2015 Jul; 36(7):1349-54. PMID: 25857757.
        View in: PubMed
      12. Solomon DA, Brohl AS, Khan J, Miettinen M. Clinicopathologic features of a second patient with Ewing-like sarcoma harboring CIC-FOXO4 gene fusion. Am J Surg Pathol. 2014 Dec; 38(12):1724-5. PMID: 25321332; PMCID: PMC4229425 [Available on 12/01/15].
      13. Hashizume R, Andor N, Ihara Y, Lerner R, Gan H, Chen X, Fang D, Huang X, Tom MW, Ngo V, Solomon D, Mueller S, Paris PL, Zhang Z, Petritsch C, Gupta N, Waldman TA, James CD. Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma. Nat Med. 2014 Dec; 20(12):1394-6. PMID: 25401693; PMCID: PMC4257862.
      14. Raygor KP, Rowland NC, Cooke DL, Solomon DA, Huang MC. Aneurysm of the posterior meningeal artery embedded within a dorsal exophytic medullary hemangioblastoma: surgical management and review of literature. J Cerebrovasc Endovasc Neurosurg. 2014 Sep; 16(3):293-8. PMID: 25340034; PMCID: PMC4205258.
      15. Walia V, Prickett TD, Kim JS, Gartner JJ, Lin JC, Zhou M, Rosenberg SA, Elble RC, Solomon DA, Waldman T, Samuels Y. Mutational and functional analysis of the tumor-suppressor PTPRD in human melanoma. Hum Mutat. 2014 Nov; 35(11):1301-10. PMID: 25113440; PMCID: PMC4394620.
      16. Brohl AS, Solomon DA, Chang W, Wang J, Song Y, Sindiri S, Patidar R, Hurd L, Chen L, Shern JF, Liao H, Wen X, Gerard J, Kim JS, Lopez Guerrero JA, Machado I, Wai DH, Picci P, Triche T, Horvai AE, Miettinen M, Wei JS, Catchpool D, Llombart-Bosch A, Waldman T, Khan J. The genomic landscape of the Ewing Sarcoma family of tumors reveals recurrent STAG2 mutation. PLoS Genet. 2014 Jul; 10(7):e1004475. PMID: 25010205; PMCID: PMC4091782.
      17. Solomon DA, Kim JS, Waldman T. Cohesin gene mutations in tumorigenesis: from discovery to clinical significance. BMB Rep. 2014 Jun; 47(6):299-310. PMID: 24856830; PMCID: PMC4163871.
      18. Bailey ML, O'Neil NJ, van Pel DM, Solomon DA, Waldman T, Hieter P. Glioblastoma cells containing mutations in the cohesin component STAG2 are sensitive to PARP inhibition. Mol Cancer Ther. 2014 Mar; 13(3):724-32. PMID: 24356817; PMCID: PMC4130349.
      19. Solomon DA, Kim JS, Bondaruk J, Shariat SF, Wang ZF, Elkahloun AG, Ozawa T, Gerard J, Zhuang D, Zhang S, Navai N, Siefker-Radtke A, Phillips JJ, Robinson BD, Rubin MA, Volkmer B, Hautmann R, Küfer R, Hogendoorn PC, Netto G, Theodorescu D, James CD, Czerniak B, Miettinen M, Waldman T. Frequent truncating mutations of STAG2 in bladder cancer. Nat Genet. 2013 Dec; 45(12):1428-30. PMID: 24121789; PMCID: PMC3875130.
      20. Solomon DA, Antonescu CR, Link TM, O'Donnell RJ, Folpe AL, Horvai AE. Hemosiderotic fibrolipomatous tumor, not an entirely benign entity. Am J Surg Pathol. 2013 Oct; 37(10):1627-30. PMID: 24025526.
        View in: PubMed
      21. Nicolaides TP, Li H, Solomon DA, Hariono S, Hashizume R, Barkovich K, Baker SJ, Paugh BS, Jones C, Forshew T, Hindley GF, Hodgson JG, Kim JS, Rowitch DH, Weiss WA, Waldman TA, James CD. Targeted therapy for BRAFV600E malignant astrocytoma. Clin Cancer Res. 2011 Dec 15; 17(24):7595-604. PMID: 22038996; PMCID: PMC3638050.
      22. Solomon DA, Kim T, Diaz-Martinez LA, Fair J, Elkahloun AG, Harris BT, Toretsky JA, Rosenberg SA, Shukla N, Ladanyi M, Samuels Y, James CD, Yu H, Kim JS, Waldman T. Mutational inactivation of STAG2 causes aneuploidy in human cancer. Science. 2011 Aug 19; 333(6045):1039-43. PMID: 21852505; PMCID: PMC3374335.
      23. Kim JS, Xu X, Li H, Solomon D, Lane WS, Jin T, Waldman T. Mechanistic analysis of a DNA damage-induced, PTEN-dependent size checkpoint in human cells. Mol Cell Biol. 2011 Jul; 31(13):2756-71. PMID: 21536651; PMCID: PMC3133370.
      24. Duncan CG, Killela PJ, Payne CA, Lampson B, Chen WC, Liu J, Solomon D, Waldman T, Towers AJ, Gregory SG, McDonald KL, McLendon RE, Bigner DD, Yan H. Integrated genomic analyses identify ERRFI1 and TACC3 as glioblastoma-targeted genes. Oncotarget. 2010 Aug; 1(4):265-77. PMID: 21113414.
        View in: PubMed
      25. Lopez GY, Reitman ZJ, Solomon D, Waldman T, Bigner DD, McLendon RE, Rosenberg SA, Samuels Y, Yan H. IDH1(R132) mutation identified in one human melanoma metastasis, but not correlated with metastases to the brain. Biochem Biophys Res Commun. 2010 Jul 30; 398(3):585-7. PMID: 20603105; PMCID: PMC2987603.
      26. Michaud K, Solomon DA, Oermann E, Kim JS, Zhong WZ, Prados MD, Ozawa T, James CD, Waldman T. Pharmacologic inhibition of cyclin-dependent kinases 4 and 6 arrests the growth of glioblastoma multiforme intracranial xenografts. Cancer Res. 2010 Apr 15; 70(8):3228-38. PMID: 20354191; PMCID: PMC2855904.
      27. Solomon DA, Kim JS, Ressom HW, Sibenaller Z, Ryken T, Jean W, Bigner D, Yan H, Waldman T. Sample type bias in the analysis of cancer genomes. Cancer Res. 2009 Jul 15; 69(14):5630-3. PMID: 19567670; PMCID: PMC3690469.
      28. Solomon DA, Kim JS, Yang XR, Tucker MA, Goldstein AM, Samuels Y, Waldman T. Lack of inherited mutations of PTPRD in familial melanoma and melanoma-astrocytoma syndrome. Pigment Cell Melanoma Res. 2009 Aug; 22(4):489-91. PMID: 19500277; PMCID: PMC2758084.
      29. Bourgo RJ, Siddiqui H, Fox S, Solomon D, Sansam CG, Yaniv M, Muchardt C, Metzger D, Chambon P, Roberts CW, Knudsen ES. SWI/SNF deficiency results in aberrant chromatin organization, mitotic failure, and diminished proliferative capacity. Mol Biol Cell. 2009 Jul; 20(14):3192-9. PMID: 19458193; PMCID: PMC2710832.
      30. Stengel KR, Thangavel C, Solomon DA, Angus SP, Zheng Y, Knudsen ES. Retinoblastoma/p107/p130 pocket proteins: protein dynamics and interactions with target gene promoters. J Biol Chem. 2009 Jul 17; 284(29):19265-71. PMID: 19279001; PMCID: PMC2740551.
      31. Solomon DA, Kim JS, Cronin JC, Sibenaller Z, Ryken T, Rosenberg SA, Ressom H, Jean W, Bigner D, Yan H, Samuels Y, Waldman T. Mutational inactivation of PTPRD in glioblastoma multiforme and malignant melanoma. Cancer Res. 2008 Dec 15; 68(24):10300-6. PMID: 19074898; PMCID: PMC2760967.
      32. Solomon DA, Kim JS, Jean W, Waldman T. Conspirators in a capital crime: co-deletion of p18INK4c and p16INK4a/p14ARF/p15INK4b in glioblastoma multiforme. Cancer Res. 2008 Nov 1; 68(21):8657-60. PMID: 18974105; PMCID: PMC2828676.
      33. Solomon DA, Kim JS, Jenkins S, Ressom H, Huang M, Coppa N, Mabanta L, Bigner D, Yan H, Jean W, Waldman T. Identification of p18 INK4c as a tumor suppressor gene in glioblastoma multiforme. Cancer Res. 2008 Apr 15; 68(8):2564-9. PMID: 18381405; PMCID: PMC4394609.
      34. Kim HJ, DiBernardo AB, Sloane JA, Rasband MN, Solomon D, Kosaras B, Kwak SP, Vartanian TK. WAVE1 is required for oligodendrocyte morphogenesis and normal CNS myelination. J Neurosci. 2006 May 24; 26(21):5849-59. PMID: 16723544.
        View in: PubMed
      35. Solomon DA, Cardoso MC, Knudsen ES. Dynamic targeting of the replication machinery to sites of DNA damage. J Cell Biol. 2004 Aug 16; 166(4):455-63. PMID: 15314062; PMCID: PMC2172213.
      36. Angus SP, Mayhew CN, Solomon DA, Braden WA, Markey MP, Okuno Y, Cardoso MC, Gilbert DM, Knudsen ES. RB reversibly inhibits DNA replication via two temporally distinct mechanisms. Mol Cell Biol. 2004 Jun; 24(12):5404-20. PMID: 15169903; PMCID: PMC419877.
      37. Gunawardena RW, Siddiqui H, Solomon DA, Mayhew CN, Held J, Angus SP, Knudsen ES. Hierarchical requirement of SWI/SNF in retinoblastoma tumor suppressor-mediated repression of Plk1. J Biol Chem. 2004 Jul 9; 279(28):29278-85. PMID: 15105433.
        View in: PubMed
      38. Mayhew CN, Bosco EE, Solomon DA, Knudsen ES, Angus SP. Analysis of RB action in DNA damage checkpoint response. Methods Mol Biol. 2004; 281:3-16. PMID: 15220518.
        View in: PubMed
      39. Angus SP, Solomon DA, Kuschel L, Hennigan RF, Knudsen ES. Retinoblastoma tumor suppressor: analyses of dynamic behavior in living cells reveal multiple modes of regulation. Mol Cell Biol. 2003 Nov; 23(22):8172-88. PMID: 14585976; PMCID: PMC262398.
      40. Siddiqui H, Solomon DA, Gunawardena RW, Wang Y, Knudsen ES. Histone deacetylation of RB-responsive promoters: requisite for specific gene repression but dispensable for cell cycle inhibition. Mol Cell Biol. 2003 Nov; 23(21):7719-31. PMID: 14560017; PMCID: PMC207566.
      41. Solomon DA, Wang Y, Fox SR, Lambeck TC, Giesting S, Lan Z, Senderowicz AM, Conti CJ, Knudsen ES. Cyclin D1 splice variants. Differential effects on localization, RB phosphorylation, and cellular transformation. J Biol Chem. 2003 Aug 8; 278(32):30339-47. PMID: 12746453.
        View in: PubMed
      42. Park SK, Solomon D, Vartanian T. Growth factor control of CNS myelination. Dev Neurosci. 2001; 23(4-5):327-37. PMID: 11756748.
        View in: PubMed
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