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    David Solomon, MD, PhD

    TitleClinical Fellow
    SchoolUCSF School of Medicine
    Address505 Parnassus Ave, Moffitt
    San Francisco CA 94143
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      Collapse Biography 
      Collapse Awards and Honors
      Harold M. Weintraub Graduate Student Award2012one of twelve recipients at the Weintraub Symposium, Fred Hutchinson Cancer Research Center, Seattle
      Future Leaders in Basic Cancer Research2012one of four recipients at the 2012 American Association for Cancer Research Annual Meeting, Chicago
      Stowell-Orbison Award2014best abstract presentation by a trainee at Annual Meeting of the US & Canada Academy of Pathology
      Young Investigator Award2014best abstract presentation by a trainee, International Society of Bone and Soft Tissue Pathology
      Stowell-Orbison Award2013best abstract presentation by a trainee at Annual Meeting of the US & Canada Academy of Pathology
      Julius Krevans Award2013outstanding clinical service by a UCSF Pathology Intern, San Francisco General Hospital
      Clifford C. Kaslow Research Achievement Award2011Department of Medicine, Georgetown University Medical Center (2008 and 2011)
      Robert Dickson Graduate Prize2011recipient of inaugural award, Lombardi Cancer Center, Georgetown University Medical Center
      Best Poster Presentation, Lombardi Research Day2011Lombardi Cancer Center, Georgetown University Medical Center
      Bester poster presentation, Student Research Days2008 - 2010Georgetown University Biomedical Graduate Exposition
      Strauss Physician Scientist Training Fellowship2004 - 2012Georgetown University School of Medicine
      Howard Hughes Medical Institute student research grants2000 - 2002College of William and Mary Undergraduate Science Education and Research Program
      William and Mary Monroe Scholar1998 - 2002College of William and Mary, Williamsburg, VA
      National Merit Scholar1998

      Collapse Overview 
      Collapse Overview

      I completed my undergraduate education at the College of William and Mary from 1998-2002 with majors of Chemistry and Molecular Cell Biology, during which time I performed molecular neural development research in the lab of Dr. Margaret Saha. I spent my summers during my undergraduate training in the multiple sclerosis lab of Dr. Tim Vartanian at Harvard Medical School studying the regulation of oligodendrocyte myelination. I then worked for two years as a research assistant at the University of Cincinnati College of Medicine in the lab of Dr. Erik Knudsen studying regulation of cell growth by the retinoblastoma tumor suppressor. Thereafter I completed my medical and graduate training in the MD/PhD program at Georgetown University School of Medicine from 2004-2012 with my PhD thesis research “Identification and therapeutic targeting of novel transforming pathways in human glioblastoma multiforme” performed in the lab of Dr. Todd Waldman. I then completed a two year residency in Anatomic Pathology at the University of California, San Francisco from 2012-2014, following which I have begun a Neuropathology Fellowship also at UCSF. I am very interested in the future of molecular diagnostics for cancer pathology and the prospect of personalized targeted therapeutics based on the genetic profile of individual tumor specimens.

      Collapse Interests
      cohesin, sister chromatid cohesion, STAG2, aneuploidy, chromosomal instability, cancer genetics, genetic pathways in tumorigenesis, molecular diagnostics, next-generation sequencing, glioblastoma, glioma, neurocytoma, brain tumors, Ewing sarcoma, urothelial carcinoma, bladder cancer, Langerhans cell histiocytosis, surgical pathology, neuropathology, molecular pathology

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      Collapse Featured Publications
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      Collapse In The News

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Solomon DA, Brohl AS, Khan J, Miettinen M. Clinicopathologic Features of a Second Patient With Ewing-like Sarcoma Harboring CIC-FOXO4 Gene Fusion. Am J Surg Pathol. 2014 Dec; 38(12):1724-5.
        View in: PubMed
      2. Hashizume R, Andor N, Ihara Y, Lerner R, Gan H, Chen X, Fang D, Huang X, Tom MW, Ngo V, Solomon D, Mueller S, Paris PL, Zhang Z, Petritsch C, Gupta N, Waldman TA, James CD. Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma. Nat Med. 2014 Dec; 20(12):1394-6.
        View in: PubMed
      3. Raygor KP, Rowland NC, Cooke DL, Solomon DA, Huang MC. Aneurysm of the posterior meningeal artery embedded within a dorsal exophytic medullary hemangioblastoma: surgical management and review of literature. J Cerebrovasc Endovasc Neurosurg. 2014 Sep; 16(3):293-8.
        View in: PubMed
      4. Walia V, Prickett TD, Kim JS, Gartner JJ, Lin JC, Zhou M, Rosenberg SA, Elble RC, Solomon DA, Waldman T, Samuels Y. Mutational and Functional Analysis of the Tumor-Suppressor PTPRD in Human Melanoma. Hum Mutat. 2014 Nov; 35(11):1301-10.
        View in: PubMed
      5. Brohl AS, Solomon DA, Chang W, Wang J, Song Y, Sindiri S, Patidar R, Hurd L, Chen L, Shern JF, Liao H, Wen X, Gerard J, Kim JS, Lopez Guerrero JA, Machado I, Wai DH, Picci P, Triche T, Horvai AE, Miettinen M, Wei JS, Catchpool D, Llombart-Bosch A, Waldman T, Khan J. The genomic landscape of the Ewing Sarcoma family of tumors reveals recurrent STAG2 mutation. PLoS Genet. 2014 Jul; 10(7):e1004475.
        View in: PubMed PMC4091782
      6. Solomon DA, Kim JS, Waldman T. Cohesin gene mutations in tumorigenesis: from discovery to clinical significance. BMB Rep. 2014 Jun; 47(6):299-310.
        View in: PubMed
      7. Bailey ML, O'Neil NJ, van Pel DM, Solomon DA, Waldman T, Hieter P. Glioblastoma cells containing mutations in the cohesin component STAG2 are sensitive to PARP inhibition. Mol Cancer Ther. 2014 Mar; 13(3):724-32.
        View in: PubMed
      8. Solomon DA, Kim JS, Bondaruk J, Shariat SF, Wang ZF, Elkahloun AG, Ozawa T, Gerard J, Zhuang D, Zhang S, Navai N, Siefker-Radtke A, Phillips JJ, Robinson BD, Rubin MA, Volkmer B, Hautmann R, Küfer R, Hogendoorn PC, Netto G, Theodorescu D, James CD, Czerniak B, Miettinen M, Waldman T. Frequent truncating mutations of STAG2 in bladder cancer. Nat Genet. 2013 Dec; 45(12):1428-30.
        View in: PubMed
      9. Solomon DA, Antonescu CR, Link TM, O'Donnell RJ, Folpe AL, Horvai AE. Hemosiderotic fibrolipomatous tumor, not an entirely benign entity. Am J Surg Pathol. 2013 Oct; 37(10):1627-30.
        View in: PubMed
      10. Nicolaides TP, Li H, Solomon DA, Hariono S, Hashizume R, Barkovich K, Baker SJ, Paugh BS, Jones C, Forshew T, Hindley GF, Hodgson JG, Kim JS, Rowitch DH, Weiss WA, Waldman TA, James CD. Targeted therapy for BRAFV600E malignant astrocytoma. Clin Cancer Res. 2011 Dec 15; 17(24):7595-604.
        View in: PubMed
      11. Solomon DA, Kim T, Diaz-Martinez LA, Fair J, Elkahloun AG, Harris BT, Toretsky JA, Rosenberg SA, Shukla N, Ladanyi M, Samuels Y, James CD, Yu H, Kim JS, Waldman T. Mutational inactivation of STAG2 causes aneuploidy in human cancer. Science. 2011 Aug 19; 333(6045):1039-43.
        View in: PubMed
      12. Kim JS, Xu X, Li H, Solomon D, Lane WS, Jin T, Waldman T. Mechanistic analysis of a DNA damage-induced, PTEN-dependent size checkpoint in human cells. Mol Cell Biol. 2011 Jul; 31(13):2756-71.
        View in: PubMed PMC3133370
      13. Duncan CG, Killela PJ, Payne CA, Lampson B, Chen WC, Liu J, Solomon D, Waldman T, Towers AJ, Gregory SG, McDonald KL, McLendon RE, Bigner DD, Yan H. Integrated genomic analyses identify ERRFI1 and TACC3 as glioblastoma-targeted genes. Oncotarget. 2010 Aug; 1(4):265-77.
        View in: PubMed
      14. Lopez GY, Reitman ZJ, Solomon D, Waldman T, Bigner DD, McLendon RE, Rosenberg SA, Samuels Y, Yan H. IDH1(R132) mutation identified in one human melanoma metastasis, but not correlated with metastases to the brain. Biochem Biophys Res Commun. 2010 Jul 30; 398(3):585-7.
        View in: PubMed
      15. Michaud K, Solomon DA, Oermann E, Kim JS, Zhong WZ, Prados MD, Ozawa T, James CD, Waldman T. Pharmacologic inhibition of cyclin-dependent kinases 4 and 6 arrests the growth of glioblastoma multiforme intracranial xenografts. Cancer Res. 2010 Apr 15; 70(8):3228-38.
        View in: PubMed
      16. Solomon DA, Kim JS, Ressom HW, Sibenaller Z, Ryken T, Jean W, Bigner D, Yan H, Waldman T. Sample type bias in the analysis of cancer genomes. Cancer Res. 2009 Jul 15; 69(14):5630-3.
        View in: PubMed
      17. Solomon DA, Kim JS, Yang XR, Tucker MA, Goldstein AM, Samuels Y, Waldman T. Lack of inherited mutations of PTPRD in familial melanoma and melanoma-astrocytoma syndrome. Pigment Cell Melanoma Res. 2009 Aug; 22(4):489-91.
        View in: PubMed
      18. Bourgo RJ, Siddiqui H, Fox S, Solomon D, Sansam CG, Yaniv M, Muchardt C, Metzger D, Chambon P, Roberts CW, Knudsen ES. SWI/SNF deficiency results in aberrant chromatin organization, mitotic failure, and diminished proliferative capacity. Mol Biol Cell. 2009 Jul; 20(14):3192-9.
        View in: PubMed
      19. Stengel KR, Thangavel C, Solomon DA, Angus SP, Zheng Y, Knudsen ES. Retinoblastoma/p107/p130 pocket proteins: protein dynamics and interactions with target gene promoters. J Biol Chem. 2009 Jul 17; 284(29):19265-71.
        View in: PubMed
      20. Solomon DA, Kim JS, Cronin JC, Sibenaller Z, Ryken T, Rosenberg SA, Ressom H, Jean W, Bigner D, Yan H, Samuels Y, Waldman T. Mutational inactivation of PTPRD in glioblastoma multiforme and malignant melanoma. Cancer Res. 2008 Dec 15; 68(24):10300-6.
        View in: PubMed
      21. Solomon DA, Kim JS, Jean W, Waldman T. Conspirators in a capital crime: co-deletion of p18INK4c and p16INK4a/p14ARF/p15INK4b in glioblastoma multiforme. Cancer Res. 2008 Nov 1; 68(21):8657-60.
        View in: PubMed
      22. Solomon DA, Kim JS, Jenkins S, Ressom H, Huang M, Coppa N, Mabanta L, Bigner D, Yan H, Jean W, Waldman T. Identification of p18 INK4c as a tumor suppressor gene in glioblastoma multiforme. Cancer Res. 2008 Apr 15; 68(8):2564-9.
        View in: PubMed
      23. Kim HJ, DiBernardo AB, Sloane JA, Rasband MN, Solomon D, Kosaras B, Kwak SP, Vartanian TK. WAVE1 is required for oligodendrocyte morphogenesis and normal CNS myelination. J Neurosci. 2006 May 24; 26(21):5849-59.
        View in: PubMed
      24. Solomon DA, Cardoso MC, Knudsen ES. Dynamic targeting of the replication machinery to sites of DNA damage. J Cell Biol. 2004 Aug 16; 166(4):455-63.
        View in: PubMed
      25. Angus SP, Mayhew CN, Solomon DA, Braden WA, Markey MP, Okuno Y, Cardoso MC, Gilbert DM, Knudsen ES. RB reversibly inhibits DNA replication via two temporally distinct mechanisms. Mol Cell Biol. 2004 Jun; 24(12):5404-20.
        View in: PubMed
      26. Gunawardena RW, Siddiqui H, Solomon DA, Mayhew CN, Held J, Angus SP, Knudsen ES. Hierarchical requirement of SWI/SNF in retinoblastoma tumor suppressor-mediated repression of Plk1. J Biol Chem. 2004 Jul 9; 279(28):29278-85.
        View in: PubMed
      27. Mayhew CN, Bosco EE, Solomon DA, Knudsen ES, Angus SP. Analysis of RB action in DNA damage checkpoint response. Methods Mol Biol. 2004; 281:3-16.
        View in: PubMed
      28. Angus SP, Solomon DA, Kuschel L, Hennigan RF, Knudsen ES. Retinoblastoma tumor suppressor: analyses of dynamic behavior in living cells reveal multiple modes of regulation. Mol Cell Biol. 2003 Nov; 23(22):8172-88.
        View in: PubMed PMC262398
      29. Siddiqui H, Solomon DA, Gunawardena RW, Wang Y, Knudsen ES. Histone deacetylation of RB-responsive promoters: requisite for specific gene repression but dispensable for cell cycle inhibition. Mol Cell Biol. 2003 Nov; 23(21):7719-31.
        View in: PubMed
      30. Solomon DA, Wang Y, Fox SR, Lambeck TC, Giesting S, Lan Z, Senderowicz AM, Conti CJ, Knudsen ES. Cyclin D1 splice variants. Differential effects on localization, RB phosphorylation, and cellular transformation. J Biol Chem. 2003 Aug 8; 278(32):30339-47.
        View in: PubMed
      31. Park SK, Solomon D, Vartanian T. Growth factor control of CNS myelination. Dev Neurosci. 2001; 23(4-5):327-37.
        View in: PubMed
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