Jason Gestwicki, PhD
|Address||675 Nelson Rising Lane|
San Francisco CA 94158
|University of Michigan||2012||American Association for the Advancement of Science (AAAS) Fellow|
|University of Michigan||2009||NSF CAREER Award|
|University of Michigan||2006||McKnight Foundation's Brain Disorders Award|
|University of Michigan||2005||Biological Sciences Scholar|
|Stanford Univeristy||2003||Helen Hay Whitney Foundation Fellow|
|University of Wisconsin - Madison||2001||Sigrid Leirmo Award|
|University of Wisconsin - Madison||1998||NIH Biotechnology Training Fellow|
The Gestwicki Laboratory is interested in molecular chaperones, protein homeostasis and protein misfolding disorders. To approach the big questions in this area, we use a chemical biology strategy that includes the discovery and optimization of new chemical inhibitors. We use these chemical probes to acutely perturb chaperone functions, revealing how these systems normally protect from cancer and neurodegeneration. Many of our chemical probes target allosteric and protein-protein interaction sites on the molecular chaperones and we have a significant interest in discovering inhibitors of "difficult" targets. We hope to better understand the logic of protein folding and misfolding and use this information to design more effective therapies.
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