Jason Gestwicki, PhD

SchoolUCSF School of Medicine
DepartmentInstitute for Neurodegenerative Diseases
Address675 Nelson Rising Lane
San Francisco CA 94158
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    Collapse Biography 
    Collapse Awards and Honors
    University of Michigan2012American Association for the Advancement of Science (AAAS) Fellow
    University of Michigan2009NSF CAREER Award
    University of Michigan2006McKnight Foundation's Brain Disorders Award
    University of Michigan2005Biological Sciences Scholar
    Stanford Univeristy2003Helen Hay Whitney Foundation Fellow
    University of Wisconsin - Madison2001Sigrid Leirmo Award
    University of Wisconsin - Madison1998NIH Biotechnology Training Fellow

    Collapse Overview 
    Collapse Overview
    The Gestwicki Laboratory is interested in molecular chaperones, protein homeostasis and protein misfolding disorders. To approach the big questions in this area, we use a chemical biology strategy that includes the discovery and optimization of new chemical inhibitors. We use these chemical probes to acutely perturb chaperone functions, revealing how these systems normally protect from cancer and neurodegeneration. Many of our chemical probes target allosteric and protein-protein interaction sites on the molecular chaperones and we have a significant interest in discovering inhibitors of "difficult" targets. We hope to better understand the logic of protein folding and misfolding and use this information to design more effective therapies.

    Collapse Research 
    Collapse Research Activities and Funding
    Activation of the 20S Proteasome to Normalize Tau Homeostasis
    NIH/NIA R21AG053619Aug 15, 2016 - May 31, 2018
    Role: Principal Investigator
    Exploration of Molecular Chaperone Complexes During Active Protein Triage
    NIH/NIGMS R01GM109896Jun 1, 2014 - Feb 28, 2018
    Role: Co-Principal Investigator
    Chemical Probes and Chaperone-Accelerated Turnover of Tau
    NIH/NIA R21AG042813Aug 1, 2012 - Jul 31, 2014
    Role: Principal Investigator
    Natural Product-Inspired Method for Enhancing HIV Protease Inhibitors
    NIH/NIAID R21AI098431Feb 1, 2012 - Jan 31, 2014
    Role: Principal Investigator
    Molecular Chaperones and Small Molecules
    NIH/NINDS R01NS059690Feb 1, 2008 - Jul 31, 2018
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Young ZT, Mok SA, Gestwicki J. Therapeutic Strategies for Restoring Tau Homeostasis. Cold Spring Harb Perspect Med. 2017 Feb 03. PMID: 28159830.
      View in: PubMed
    2. Rauch JN, Olson SH, Gestwicki JE. Interactions between Microtubule-Associated Protein Tau (MAPT) and Small Molecules. Cold Spring Harb Perspect Med. 2016 Dec 09. PMID: 27940599.
      View in: PubMed
    3. Rauch JN, Tse E, Freilich R, Mok SA, Makley LN, Southworth DR, Gestwicki JE. BAG3 is a modular, scaffolding protein that physically links heat shock protein 70 (Hsp70) to the small heat shock proteins. J Mol Biol. 2016 Nov 21. PMID: 27884606.
      View in: PubMed
    4. Zuiderweg ER, Gestwicki JE. Backbone and methyl resonance assignments of the 42 kDa human Hsc70 nucleotide binding domain in the ADP state. Biomol NMR Assign. 2016 Oct 3. PMID: 27699616.
      View in: PubMed
    5. Costa MD, Ashraf NS, Fischer S, Yang Y, Schapka E, Joshi G, McQuade TJ, Dharia RM, Dulchavsky M, Ouyang M, Cook D, Sun D, Larsen MJ, Gestwicki JE, Todi SV, Ivanova MI, Paulson HL. Unbiased screen identifies aripiprazole as a modulator of abundance of the polyglutamine disease protein, ataxin-3. Brain. 2016 Sep 19. PMID: 27645800.
      View in: PubMed
    6. Gabai VL, Yaglom JA, Wang Y, Meng L, Shao H, Kim G, Colvin T, Gestwicki J, Sherman MY. Anticancer Effects of Targeting Hsp70 in Tumor Stromal Cells. Cancer Res. 2016 Oct 15; 76(20):5926-5932. PMID: 27503927.
      View in: PubMed
    7. Young ZT, Rauch JN, Assimon VA, Jinwal UK, Ahn M, Li X, Dunyak BM, Ahmad A, Carlson GA, Srinivasan SR, Zuiderweg ER, Dickey CA, Gestwicki JE. Stabilizing the Hsp70-Tau Complex Promotes Turnover in Models of Tauopathy. Cell Chem Biol. 2016 Aug 18; 23(8):992-1001. PMID: 27499529.
      View in: PubMed
    8. Rauch JN, Zuiderweg ER, Gestwicki JE. Non-canonical Interactions between Heat Shock Cognate Protein 70 (Hsc70) and Bcl2-associated Anthanogene (BAG) Co-Chaperones Are Important for Client Release. J Biol Chem. 2016 Sep 16; 291(38):19848-57. PMID: 27474739.
      View in: PubMed
    9. Ouimet CM, Shao H, Rauch JN, Dawod M, Nordhues B, Dickey CA, Gestwicki JE, Kennedy RT. Protein Cross-Linking Capillary Electrophoresis for Protein-Protein Interaction Analysis. Anal Chem. 2016 Aug 16; 88(16):8272-8. PMID: 27434096.
      View in: PubMed
    10. Dunyak BM, Gestwicki JE. Peptidyl-Proline Isomerases (PPIases): Targets for Natural Products and Natural Product-Inspired Compounds. J Med Chem. 2016 Nov 10; 59(21):9622-9644. PMID: 27409354.
      View in: PubMed
    11. Sabnis AJ, Guerriero CJ, Olivas V, Sayana A, Shue J, Flanagan J, Asthana S, Paton AW, Paton JC, Gestwicki JE, Walter P, Weissman JS, Wipf P, Brodsky JL, Bivona TG. Combined chemical-genetic approach identifies cytosolic HSP70 dependence in rhabdomyosarcoma. Proc Natl Acad Sci U S A. 2016 Aug 9; 113(32):9015-20. PMID: 27450084.
      View in: PubMed
    12. Morozova K, Clement CC, Kaushik S, Stiller B, Arias E, Ahmad A, Rauch JN, Chatterjee V, Melis C, Scharf B, Gestwicki JE, Cuervo AM, Zuiderweg ER, Santambrogio L. Structural and Biological Interaction of hsc-70 Protein with Phosphatidylserine in Endosomal Microautophagy. J Biol Chem. 2016 Aug 26; 291(35):18096-106. PMID: 27405763.
      View in: PubMed
    13. Martin MD, Baker JD, Suntharalingam A, Nordhues BA, Shelton LB, Zheng D, Sabbagh JJ, Haystead TA, Gestwicki J, Dickey CA. Inhibition of Both Hsp70 Activity and Tau Aggregation in Vitro Best Predicts Tau Lowering Activity of Small Molecules. ACS Chem Biol. 2016 Jul 15; 11(7):2041-8. PMID: 27177119.
      View in: PubMed
    14. Paatero AO, Kellosalo J, Dunyak BM, Almaliti J, Gestwicki JE, Gerwick WH, Taunton J, Paavilainen VO. Apratoxin Kills Cells by Direct Blockade of the Sec61 Protein Translocation Channel. Cell Chem Biol. 2016 May 19; 23(5):561-6. PMID: 27203376.
      View in: PubMed
    15. Li X, Shao H, Taylor IR, Gestwicki J. Targeting Allosteric Control Mechanisms in Heat Shock Protein 70 (Hsp70). Curr Top Med Chem. 2016 Apr 13. PMID: 27072701.
      View in: PubMed
    16. Khachatoorian R, Riahi R, Ganapathy E, Shao H, Wheatley NM, Sundberg C, Jung CL, Ruchala P, Dasgupta A, Arumugaswami V, Gestwicki J, French SW. Allosteric heat shock protein 70 inhibitors block hepatitis C virus assembly. Int J Antimicrob Agents. 2016 Apr; 47(4):289-96. PMID: 27013001.
      View in: PubMed
    17. Assimon VA, Southworth DR, Gestwicki J. Specific Binding of Tetratricopeptide Repeat Proteins to Heat Shock Protein 70 (Hsp70) and Heat Shock Protein 90 (Hsp90) Is Regulated by Affinity and Phosphorylation. Biochemistry. 2015 Dec 8; 54(48):7120-31. PMID: 26565746.
      View in: PubMed
    18. Taguwa S, Maringer K, Li X, Bernal-Rubio D, Rauch JN, Gestwicki JE, Andino R, Fernandez-Sesma A, Frydman J. Defining Hsp70 Subnetworks in Dengue Virus Replication Reveals Key Vulnerability in Flavivirus Infection. Cell. 2015 Nov 19; 163(5):1108-23. PMID: 26582131.
      View in: PubMed
    19. Makley LN, McMenimen KA, DeVree BT, Goldman JW, McGlasson BN, Rajagopal P, Dunyak BM, McQuade TJ, Thompson AD, Sunahara R, Klevit RE, Andley UP, Gestwicki JE. Pharmacological chaperone for a-crystallin partially restores transparency in cataract models. Science. 2015 Nov 6; 350(6261):674-7. PMID: 26542570.
      View in: PubMed
    20. Min SW, Chen X, Tracy TE, Li Y, Zhou Y, Wang C, Shirakawa K, Minami SS, Defensor E, Mok SA, Sohn PD, Schilling B, Cong X, Ellerby L, Gibson BW, Johnson J, Krogan N, Shamloo M, Gestwicki J, Masliah E, Verdin E, Gan L. Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits. Nat Med. 2015 Oct; 21(10):1154-62. PMID: 26390242; PMCID: PMC4598295 [Available on 04/01/16].
    21. Dunyak BM, Nakamura RL, Frankel AD, Gestwicki JE. Selective Targeting of Cells via Bispecific Molecules That Exploit Coexpression of Two Intracellular Proteins. ACS Chem Biol. 2015 Nov 20; 10(11):2441-7. PMID: 26322864.
      View in: PubMed
    22. Cesa LC, Mapp AK, Gestwicki JE. Direct and Propagated Effects of Small Molecules on Protein-Protein Interaction Networks. Front Bioeng Biotechnol. 2015; 3:119. PMID: 26380257; PMCID: PMC4547496.
    23. Guan S, Trnka MJ, Bushnell DA, Robinson PJ, Gestwicki JE, Burlingame AL. Deconvolution method for specific and nonspecific binding of ligand to multiprotein complex by native mass spectrometry. Anal Chem. 2015 Aug 18; 87(16):8541-6. PMID: 26189511.
      View in: PubMed
    24. Fontaine SN, Martin MD, Akoury E, Assimon VA, Borysov S, Nordhues BA, Sabbagh JJ, Cockman M, Gestwicki JE, Zweckstetter M, Dickey CA. The active Hsc70/tau complex can be exploited to enhance tau turnover without damaging microtubule dynamics. Hum Mol Genet. 2015 Jul 15; 24(14):3971-81. PMID: 25882706; PMCID: PMC4560066 [Available on 07/15/16].
    25. Fontaine SN, Rauch JN, Nordhues BA, Assimon VA, Stothert AR, Jinwal UK, Sabbagh JJ, Chang L, Stevens SM, Zuiderweg ER, Gestwicki JE, Dickey CA. Isoform-selective Genetic Inhibition of Constitutive Cytosolic Hsp70 Activity Promotes Client Tau Degradation Using an Altered Co-chaperone Complement. J Biol Chem. 2015 May 22; 290(21):13115-27. PMID: 25864199; PMCID: PMC4505567 [Available on 05/22/16].
    26. Assimon VA, Shao H, Garneau-Tsodikova S, Gestwicki JE. Concise Synthesis of Spergualin-Inspired Molecules With Broad-Spectrum Antibiotic Activity. Medchemcomm. 2015 May 1; 6(5):912-918. PMID: 27087913.
      View in: PubMed
    27. Martin MD, Calcul L, Smith C, Jinwal UK, Fontaine SN, Darling A, Seeley K, Wojtas L, Narayan M, Gestwicki JE, Smith GR, Reitz AB, Baker BJ, Dickey CA. Synthesis, stereochemical analysis, and derivatization of myricanol provide new probes that promote autophagic tau clearance. ACS Chem Biol. 2015 Apr 17; 10(4):1099-109. PMID: 25588114.
      View in: PubMed
    28. Li X, Colvin T, Rauch JN, Acosta-Alvear D, Kampmann M, Dunyak B, Hann B, Aftab BT, Murnane M, Cho M, Walter P, Weissman JS, Sherman MY, Gestwicki JE. Validation of the Hsp70-Bag3 protein-protein interaction as a potential therapeutic target in cancer. Mol Cancer Ther. 2015 Mar; 14(3):642-8. PMID: 25564440; PMCID: PMC4456214 [Available on 03/01/16].
    29. Evans CG, Gestwicki J. Correction to enantioselective organocatalytic hantzsch synthesis of polyhydroquinolines. Org Lett. 2014 Nov 21; 16(22):6040. PMID: 25275212.
      View in: PubMed
    30. Pratt WB, Gestwicki JE, Osawa Y, Lieberman AP. Targeting Hsp90/Hsp70-based protein quality control for treatment of adult onset neurodegenerative diseases. Annu Rev Pharmacol Toxicol. 2015; 55:353-71. PMID: 25292434; PMCID: PMC4372135 [Available on 01/01/16].
    31. Jaeger AM, Makley LN, Gestwicki JE, Thiele DJ. Genomic heat shock element sequences drive cooperative human heat shock factor 1 DNA binding and selectivity. J Biol Chem. 2014 Oct 31; 289(44):30459-69. PMID: 25204655; PMCID: PMC4215228.
    32. Selenica ML, Davtyan H, Housley SB, Blair LJ, Gillies A, Nordhues BA, Zhang B, Liu J, Gestwicki JE, Lee DC, Gordon MN, Morgan D, Dickey CA. Epitope analysis following active immunization with tau proteins reveals immunogens implicated in tau pathogenesis. J Neuroinflammation. 2014; 11:152. PMID: 25183004; PMCID: PMC4167523.
    33. Rauch JN, Gestwicki JE. Rehabilitating mutant GCase. Chem Biol. 2014 Aug 14; 21(8):919-20. PMID: 25126987.
      View in: PubMed
    34. Ung PM, Dunbar JB, Gestwicki JE, Carlson HA. An allosteric modulator of HIV-1 protease shows equipotent inhibition of wild-type and drug-resistant proteases. J Med Chem. 2014 Aug 14; 57(15):6468-78. PMID: 25062388; PMCID: PMC4136727.
    35. Colvin TA, Gabai VL, Gong J, Calderwood SK, Li H, Gummuluru S, Matchuk ON, Smirnova SG, Orlova NV, Zamulaeva IA, Garcia-Marcos M, Li X, Young ZT, Rauch JN, Gestwicki JE, Takayama S, Sherman MY. Hsp70-Bag3 interactions regulate cancer-related signaling networks. Cancer Res. 2014 Sep 1; 74(17):4731-40. PMID: 24994713; PMCID: PMC4174322.
    36. Pratt WB, Morishima Y, Gestwicki JE, Lieberman AP, Osawa Y. A model in which heat shock protein 90 targets protein-folding clefts: rationale for a new approach to neuroprotective treatment of protein folding diseases. Exp Biol Med (Maywood). 2014 Nov; 239(11):1405-13. PMID: 24990484; PMCID: PMC4318483.
    37. Walter GM, Raveh A, Mok SA, McQuade TJ, Arevang CJ, Schultz PJ, Smith MC, Asare S, Cruz PG, Wisen S, Matainaho T, Sherman DH, Gestwicki JE. High-throughput screen of natural product extracts in a yeast model of polyglutamine proteotoxicity. Chem Biol Drug Des. 2014 Apr; 83(4):440-9. PMID: 24636344; PMCID: PMC4068144.
    38. Connarn JN, Assimon VA, Reed RA, Tse E, Southworth DR, Zuiderweg ER, Gestwicki JE, Sun D. The molecular chaperone Hsp70 activates protein phosphatase 5 (PP5) by binding the tetratricopeptide repeat (TPR) domain. J Biol Chem. 2014 Jan 31; 289(5):2908-17. PMID: 24327656; PMCID: PMC3908423.
    39. Rauch JN, Gestwicki JE. Binding of human nucleotide exchange factors to heat shock protein 70 (Hsp70) generates functionally distinct complexes in vitro. J Biol Chem. 2014 Jan 17; 289(3):1402-14. PMID: 24318877; PMCID: PMC3894324.
    40. Ung PM, Thompson AD, Chang L, Gestwicki JE, Carlson HA. Identification of key hinge residues important for nucleotide-dependent allostery in E. coli Hsp70/DnaK. PLoS Comput Biol. 2013; 9(11):e1003279. PMID: 24277995; PMCID: PMC3836694.
    41. Li X, Srinivasan SR, Connarn J, Ahmad A, Young ZT, Kabza AM, Zuiderweg ER, Sun D, Gestwicki J. Analogs of the Allosteric Heat Shock Protein 70 (Hsp70) Inhibitor, MKT-077, as Anti-Cancer Agents. ACS Med Chem Lett. 2013 Nov 14; 4(11). PMID: 24312699.
      View in: PubMed
    42. Rauch JN, Nie J, Buchholz TJ, Gestwicki JE, Kennedy RT. Development of a capillary electrophoresis platform for identifying inhibitors of protein-protein interactions. Anal Chem. 2013 Oct 15; 85(20):9824-31. PMID: 24060167; PMCID: PMC3845662.
    43. Smith MC, Scaglione KM, Assimon VA, Patury S, Thompson AD, Dickey CA, Southworth DR, Paulson HL, Gestwicki JE, Zuiderweg ER. The E3 ubiquitin ligase CHIP and the molecular chaperone Hsc70 form a dynamic, tethered complex. Biochemistry. 2013 Aug 13; 52(32):5354-64. PMID: 23865999; PMCID: PMC3856692.
    44. Cesa LC, Patury S, Komiyama T, Ahmad A, Zuiderweg ER, Gestwicki JE. Inhibitors of difficult protein-protein interactions identified by high-throughput screening of multiprotein complexes. ACS Chem Biol. 2013 Sep 20; 8(9):1988-97. PMID: 23819499; PMCID: PMC3783524.
    45. Dunbar JB, Smith RD, Damm-Ganamet KL, Ahmed A, Esposito EX, Delproposto J, Chinnaswamy K, Kang YN, Kubish G, Gestwicki JE, Stuckey JA, Carlson HA. CSAR data set release 2012: ligands, affinities, complexes, and docking decoys. J Chem Inf Model. 2013 Aug 26; 53(8):1842-52. PMID: 23617227; PMCID: PMC3753885.
    46. Abisambra J, Jinwal UK, Miyata Y, Rogers J, Blair L, Li X, Seguin SP, Wang L, Jin Y, Bacon J, Brady S, Cockman M, Guidi C, Zhang J, Koren J, Young ZT, Atkins CA, Zhang B, Lawson LY, Weeber EJ, Brodsky JL, Gestwicki JE, Dickey CA. Allosteric heat shock protein 70 inhibitors rapidly rescue synaptic plasticity deficits by reducing aberrant tau. Biol Psychiatry. 2013 Sep 1; 74(5):367-74. PMID: 23607970; PMCID: PMC3740016.
    47. Miyata Y, Li X, Lee HF, Jinwal UK, Srinivasan SR, Seguin SP, Young ZT, Brodsky JL, Dickey CA, Sun D, Gestwicki JE. Synthesis and initial evaluation of YM-08, a blood-brain barrier permeable derivative of the heat shock protein 70 (Hsp70) inhibitor MKT-077, which reduces tau levels. ACS Chem Neurosci. 2013 Jun 19; 4(6):930-9. PMID: 23472668; PMCID: PMC3689201.
    48. Makley LN, Gestwicki JE. Expanding the number of 'druggable' targets: non-enzymes and protein-protein interactions. Chem Biol Drug Des. 2013 Jan; 81(1):22-32. PMID: 23253128; PMCID: PMC3531880.
    49. Assimon VA, Gillies AT, Rauch JN, Gestwicki JE. Hsp70 protein complexes as drug targets. Curr Pharm Des. 2013; 19(3):404-17. PMID: 22920901; PMCID: PMC3593251.
    50. Zuiderweg ER, Bertelsen EB, Rousaki A, Mayer MP, Gestwicki JE, Ahmad A. Allostery in the Hsp70 chaperone proteins. Top Curr Chem. 2013; 328:99-153. PMID: 22576356; PMCID: PMC3623542.
    51. Jinwal UK, Akoury E, Abisambra JF, O'Leary JC, Thompson AD, Blair LJ, Jin Y, Bacon J, Nordhues BA, Cockman M, Zhang J, Li P, Zhang B, Borysov S, Uversky VN, Biernat J, Mandelkow E, Gestwicki JE, Zweckstetter M, Dickey CA. Imbalance of Hsp70 family variants fosters tau accumulation. FASEB J. 2013 Apr; 27(4):1450-9. PMID: 23271055; PMCID: PMC3606536.
    52. Wang AM, Miyata Y, Klinedinst S, Peng HM, Chua JP, Komiyama T, Li X, Morishima Y, Merry DE, Pratt WB, Osawa Y, Collins CA, Gestwicki JE, Lieberman AP. Activation of Hsp70 reduces neurotoxicity by promoting polyglutamine protein degradation. Nat Chem Biol. 2013 Feb; 9(2):112-8. PMID: 23222885; PMCID: PMC3552084.
    53. Miyata Y, Rauch JN, Jinwal UK, Thompson AD, Srinivasan S, Dickey CA, Gestwicki JE. Cysteine reactivity distinguishes redox sensing by the heat-inducible and constitutive forms of heat shock protein 70. Chem Biol. 2012 Nov 21; 19(11):1391-9. PMID: 23177194; PMCID: PMC3508472.
    54. Gillies AT, Taylor R, Gestwicki JE. Synthetic lethal interactions in yeast reveal functional roles of J protein co-chaperones. Mol Biosyst. 2012 Nov; 8(11):2901-8. PMID: 22851130; PMCID: PMC3463740.
    55. Davis MJ, Gregorka B, Gestwicki JE, Swanson JA. Inducible renitence limits Listeria monocytogenes escape from vacuoles in macrophages. J Immunol. 2012 Nov 1; 189(9):4488-95. PMID: 23002437; PMCID: PMC3478491.
    56. Seguin SP, Ireland AW, Gupta T, Wright CM, Miyata Y, Wipf P, Pipas JM, Gestwicki JE, Brodsky JL. A screen for modulators of large T antigen's ATPase activity uncovers novel inhibitors of Simian Virus 40 and BK virus replication. Antiviral Res. 2012 Oct; 96(1):70-81. PMID: 22898086; PMCID: PMC3465505.
    57. Smith MC, Gestwicki JE. Features of protein-protein interactions that translate into potent inhibitors: topology, surface area and affinity. Expert Rev Mol Med. 2012; 14:e16. PMID: 22831787; PMCID: PMC3591511.
    58. Thompson AD, Scaglione KM, Prensner J, Gillies AT, Chinnaiyan A, Paulson HL, Jinwal UK, Dickey CA, Gestwicki JE. Analysis of the tau-associated proteome reveals that exchange of Hsp70 for Hsp90 is involved in tau degradation. ACS Chem Biol. 2012 Oct 19; 7(10):1677-86. PMID: 22769591; PMCID: PMC3477299.
    59. Thompson AD, Dugan A, Gestwicki JE, Mapp AK. Fine-tuning multiprotein complexes using small molecules. ACS Chem Biol. 2012 Aug 17; 7(8):1311-20. PMID: 22725693; PMCID: PMC3517816.
    60. Srinivasan SR, Gillies AT, Chang L, Thompson AD, Gestwicki JE. Molecular chaperones DnaK and DnaJ share predicted binding sites on most proteins in the E. coli proteome. Mol Biosyst. 2012 Sep; 8(9):2323-33. PMID: 22732719; PMCID: PMC3462289.
    61. Chafekar SM, Wisén S, Thompson AD, Echeverria A, Walter GM, Evans CG, Makley LN, Gestwicki JE, Duennwald ML. Pharmacological tuning of heat shock protein 70 modulates polyglutamine toxicity and aggregation. ACS Chem Biol. 2012 Sep 21; 7(9):1556-64. PMID: 22709427; PMCID: PMC3448832.
    62. Hammer ND, McGuffie BA, Zhou Y, Badtke MP, Reinke AA, Brännström K, Gestwicki JE, Olofsson A, Almqvist F, Chapman MR. The C-terminal repeating units of CsgB direct bacterial functional amyloid nucleation. J Mol Biol. 2012 Sep 21; 422(3):376-89. PMID: 22684146; PMCID: PMC3423549.
    63. Jinwal UK, Abisambra JF, Zhang J, Dharia S, O'Leary JC, Patel T, Braswell K, Jani T, Gestwicki JE, Dickey CA. Cdc37/Hsp90 protein complex disruption triggers an autophagic clearance cascade for TDP-43 protein. J Biol Chem. 2012 Jul 13; 287(29):24814-20. PMID: 22674575; PMCID: PMC3397908.
    64. Thompson AD, Makley LN, McMenimen K, Gestwicki JE. The three cornerstones of chemical biology: innovative probes, new discoveries, and enabling tools. ACS Chem Biol. 2012 May 18; 7(5):791-6. PMID: 22594530.
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    65. Koren J, Miyata Y, Kiray J, O'Leary JC, Nguyen L, Guo J, Blair LJ, Li X, Li X, Jinwal UK, Cheng JQ, Gestwicki JE, Dickey CA. Rhodacyanine derivative selectively targets cancer cells and overcomes tamoxifen resistance. PLoS One. 2012; 7(4):e35566. PMID: 22563386; PMCID: PMC3338522.
    66. Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, Al-Younes HM, Al-Zeer MA, Albert ML, Albin RL, Alegre-Abarrategui J, Aleo MF, Alirezaei M, Almasan A, Almonte-Becerril M, Amano A, Amaravadi R, Amarnath S, Amer AO, Andrieu-Abadie N, Anantharam V, Ann DK, Anoopkumar-Dukie S, Aoki H, Apostolova N, Arancia G, Aris JP, Asanuma K, Asare NY, Ashida H, Askanas V, Askew DS, Auberger P, Baba M, Backues SK, Baehrecke EH, Bahr BA, Bai XY, Bailly Y, Baiocchi R, Baldini G, Balduini W, Ballabio A, Bamber BA, Bampton ET, Bánhegyi G, Bartholomew CR, Bassham DC, Bast RC, Batoko H, Bay BH, Beau I, Béchet DM, Begley TJ, Behl C, Behrends C, Bekri S, Bellaire B, Bendall LJ, Benetti L, Berliocchi L, Bernardi H, Bernassola F, Besteiro S, Bhatia-Kissova I, Bi X, Biard-Piechaczyk M, Blum JS, Boise LH, Bonaldo P, Boone DL, Bornhauser BC, Bortoluci KR, Bossis I, Bost F, Bourquin JP, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady NR, Brancolini C, Brech A, Brenman JE, Brennand A, Bresnick EH, Brest P, Bridges D, Bristol ML, Brookes PS, Brown EJ, Brumell JH, Brunetti-Pierri N, Brunk UT, Bulman DE, Bultman SJ, Bultynck G, Burbulla LF, Bursch W, Butchar JP, Buzgariu W, Bydlowski SP, Cadwell K, Cahová M, Cai D, Cai J, Cai Q, Calabretta B, Calvo-Garrido J, Camougrand N, Campanella M, Campos-Salinas J, Candi E, Cao L, Caplan AB, Carding SR, Cardoso SM, Carew JS, Carlin CR, Carmignac V, Carneiro LA, Carra S, Caruso RA, Casari G, Casas C, Castino R, Cebollero E, Cecconi F, Celli J, Chaachouay H, Chae HJ, Chai CY, Chan DC, Chan EY, Chang RC, Che CM, Chen CC, Chen GC, Chen GQ, Chen M, Chen Q, Chen SS, Chen W, Chen X, Chen X, Chen X, Chen YG, Chen Y, Chen Y, Chen YJ, Chen Z, Cheng A, Cheng CH, Cheng Y, Cheong H, Cheong JH, Cherry S, Chess-Williams R, Cheung ZH, Chevet E, Chiang HL, Chiarelli R, Chiba T, Chin LS, Chiou SH, Chisari FV, Cho CH, Cho DH, Choi AM, Choi D, Choi KS, Choi ME, Chouaib S, Choubey D, Choubey V, Chu CT, Chuang TH, Chueh SH, Chun T, Chwae YJ, Chye ML, Ciarcia R, Ciriolo MR, Clague MJ, Clark RS, Clarke PG, Clarke R, Codogno P, Coller HA, Colombo MI, Comincini S, Condello M, Condorelli F, Cookson MR, Coombs GH, Coppens I, Corbalan R, Cossart P, Costelli P, Costes S, Coto-Montes A, Couve E, Coxon FP, Cregg JM, Crespo JL, Cronjé MJ, Cuervo AM, Cullen JJ, Czaja MJ, D'Amelio M, Darfeuille-Michaud A, Davids LM, Davies FE, De Felici M, de Groot JF, de Haan CA, De Martino L, De Milito A, De Tata V, Debnath J, Degterev A, Dehay B, Delbridge LM, Demarchi F, Deng YZ, Dengjel J, Dent P, Denton D, Deretic V, Desai SD, Devenish RJ, Di Gioacchino M, Di Paolo G, Di Pietro C, Díaz-Araya G, Díaz-Laviada I, Diaz-Meco MT, Diaz-Nido J, Dikic I, Dinesh-Kumar SP, Ding WX, Distelhorst CW, Diwan A, Djavaheri-Mergny M, Dokudovskaya S, Dong Z, Dorsey FC, Dosenko V, Dowling JJ, Doxsey S, Dreux M, Drew ME, Duan Q, Duchosal MA, Duff K, Dugail I, Durbeej M, Duszenko M, Edelstein CL, Edinger AL, Egea G, Eichinger L, Eissa NT, Ekmekcioglu S, El-Deiry WS, Elazar Z, Elgendy M, Ellerby LM, Eng KE, Engelbrecht AM, Engelender S, Erenpreisa J, Escalante R, Esclatine A, Eskelinen EL, Espert L, Espina V, Fan H, Fan J, Fan QW, Fan Z, Fang S, Fang Y, Fanto M, Fanzani A, Farkas T, Farré JC, Faure M, Fechheimer M, Feng CG, Feng J, Feng Q, Feng Y, Fésüs L, Feuer R, Figueiredo-Pereira ME, Fimia GM, Fingar DC, Finkbeiner S, Finkel T, Finley KD, Fiorito F, Fisher EA, Fisher PB, Flajolet M, Florez-McClure ML, Florio S, Fon EA, Fornai F, Fortunato F, Fotedar R, Fowler DH, Fox HS, Franco R, Frankel LB, Fransen M, Fuentes JM, Fueyo J, Fujii J, Fujisaki K, Fujita E, Fukuda M, Furukawa RH, Gaestel M, Gailly P, Gajewska M, Galliot B, Galy V, Ganesh S, Ganetzky B, Ganley IG, Gao FB, Gao GF, Gao J, Garcia L, Garcia-Manero G, Garcia-Marcos M, Garmyn M, Gartel AL, Gatti E, Gautel M, Gawriluk TR, Gegg ME, Geng J, Germain M, Gestwicki JE, Gewirtz DA, Ghavami S, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2012 Apr; 8(4):445-544. PMID: 22966490; PMCID: PMC3404883.
    67. Congdon EE, Wu JW, Myeku N, Figueroa YH, Herman M, Marinec PS, Gestwicki JE, Dickey CA, Yu WH, Duff KE. Methylthioninium chloride (methylene blue) induces autophagy and attenuates tauopathy in vitro and in vivo. Autophagy. 2012 Apr; 8(4):609-22. PMID: 22361619; PMCID: PMC3405840.
    68. Gestwicki JE, Garza D. Protein quality control in neurodegenerative disease. Prog Mol Biol Transl Sci. 2012; 107:327-53. PMID: 22482455.
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    69. Thompson AD, Bernard SM, Skiniotis G, Gestwicki JE. Visualization and functional analysis of the oligomeric states of Escherichia coli heat shock protein 70 (Hsp70/DnaK). Cell Stress Chaperones. 2012 May; 17(3):313-27. PMID: 22076723; PMCID: PMC3312962.
    70. Walter GM, Smith MC, Wisén S, Basrur V, Elenitoba-Johnson KS, Duennwald ML, Kumar A, Gestwicki JE. Ordered assembly of heat shock proteins, Hsp26, Hsp70, Hsp90, and Hsp104, on expanded polyglutamine fragments revealed by chemical probes. J Biol Chem. 2011 Nov 25; 286(47):40486-93. PMID: 21969373; PMCID: PMC3220478.
    71. Miyata Y, Koren J, Kiray J, Dickey CA, Gestwicki JE. Molecular chaperones and regulation of tau quality control: strategies for drug discovery in tauopathies. Future Med Chem. 2011 Sep; 3(12):1523-37. PMID: 21882945; PMCID: PMC3190966.
    72. Scaglione KM, Zavodszky E, Todi SV, Patury S, Xu P, Rodríguez-Lebrón E, Fischer S, Konen J, Djarmati A, Peng J, Gestwicki JE, Paulson HL. Ube2w and ataxin-3 coordinately regulate the ubiquitin ligase CHIP. Mol Cell. 2011 Aug 19; 43(4):599-612. PMID: 21855799; PMCID: PMC3166620.
    73. Morishima Y, Lau M, Peng HM, Miyata Y, Gestwicki JE, Pratt WB, Osawa Y. Heme-dependent activation of neuronal nitric oxide synthase by cytosol is due to an Hsp70-dependent, thioredoxin-mediated thiol-disulfide interchange in the heme/substrate binding cleft. Biochemistry. 2011 Aug 23; 50(33):7146-56. PMID: 21755988; PMCID: PMC3156863.
    74. Rousaki A, Miyata Y, Jinwal UK, Dickey CA, Gestwicki JE, Zuiderweg ER. Allosteric drugs: the interaction of antitumor compound MKT-077 with human Hsp70 chaperones. J Mol Biol. 2011 Aug 19; 411(3):614-32. PMID: 21708173; PMCID: PMC3146629.
    75. Reinke AA, Gestwicki JE. Insight into amyloid structure using chemical probes. Chem Biol Drug Des. 2011 Jun; 77(6):399-411. PMID: 21457473; PMCID: PMC3097318.
    76. Evans CG, Smith MC, Carolan JP, Gestwicki JE. Improved synthesis of 15-deoxyspergualin analogs using the Ugi multi-component reaction. Bioorg Med Chem Lett. 2011 May 1; 21(9):2587-90. PMID: 21420295; PMCID: PMC3088103.
    77. Chang L, Miyata Y, Ung PM, Bertelsen EB, McQuade TJ, Carlson HA, Zuiderweg ER, Gestwicki JE. Chemical screens against a reconstituted multiprotein complex: myricetin blocks DnaJ regulation of DnaK through an allosteric mechanism. Chem Biol. 2011 Feb 25; 18(2):210-21. PMID: 21338918; PMCID: PMC3057461.
    78. Reinke AA, Ung PM, Quintero JJ, Carlson HA, Gestwicki JE. Chemical probes that selectively recognize the earliest Aß oligomers in complex mixtures. J Am Chem Soc. 2010 Dec 22; 132(50):17655-7. PMID: 21105683; PMCID: PMC3005376.
    79. Evans CG, Jinwal UK, Makley LN, Dickey CA, Gestwicki JE. Identification of dihydropyridines that reduce cellular tau levels. Chem Commun (Camb). 2011 Jan 7; 47(1):529-31. PMID: 21082080; PMCID: PMC3251959.
    80. Bainor A, Chang L, McQuade TJ, Webb B, Gestwicki JE. Bicinchoninic acid (BCA) assay in low volume. Anal Biochem. 2011 Mar 15; 410(2):310-2. PMID: 21078286.
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    81. O'Leary JC, Li Q, Marinec P, Blair LJ, Congdon EE, Johnson AG, Jinwal UK, Koren J, Jones JR, Kraft C, Peters M, Abisambra JF, Duff KE, Weeber EJ, Gestwicki JE, Dickey CA. Phenothiazine-mediated rescue of cognition in tau transgenic mice requires neuroprotection and reduced soluble tau burden. Mol Neurodegener. 2010; 5:45. PMID: 21040568; PMCID: PMC2989315.
    82. Xu T, Johnson CA, Gestwicki JE, Kumar A. Conditionally controlling nuclear trafficking in yeast by chemical-induced protein dimerization. Nat Protoc. 2010 Nov; 5(11):1831-43. PMID: 21030958.
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    83. Miyata Y, Chang L, Bainor A, McQuade TJ, Walczak CP, Zhang Y, Larsen MJ, Kirchhoff P, Gestwicki JE. High-throughput screen for Escherichia coli heat shock protein 70 (Hsp70/DnaK): ATPase assay in low volume by exploiting energy transfer. J Biomol Screen. 2010 Dec; 15(10):1211-9. PMID: 20926844; PMCID: PMC3052282.
    84. Reinke AA, Abulwerdi GA, Gestwicki JE. Quantifying prefibrillar amyloids in vitro by using a "thioflavin-like" spectroscopic method. Chembiochem. 2010 Sep 3; 11(13):1889-95. PMID: 20677203; PMCID: PMC3244937.
    85. Evans CG, Chang L, Gestwicki JE. Heat shock protein 70 (hsp70) as an emerging drug target. J Med Chem. 2010 Jun 24; 53(12):4585-602. PMID: 20334364; PMCID: PMC2895966.
    86. Wisén S, Bertelsen EB, Thompson AD, Patury S, Ung P, Chang L, Evans CG, Walter GM, Wipf P, Carlson HA, Brodsky JL, Zuiderweg ER, Gestwicki JE. Binding of a small molecule at a protein-protein interface regulates the chaperone activity of hsp70-hsp40. ACS Chem Biol. 2010 Jun 18; 5(6):611-22. PMID: 20481474; PMCID: PMC2950966.
    87. Chang L, Thompson AD, Ung P, Carlson HA, Gestwicki JE. Mutagenesis reveals the complex relationships between ATPase rate and the chaperone activities of Escherichia coli heat shock protein 70 (Hsp70/DnaK). J Biol Chem. 2010 Jul 9; 285(28):21282-91. PMID: 20439464; PMCID: PMC2898401.
    88. Wang AM, Morishima Y, Clapp KM, Peng HM, Pratt WB, Gestwicki JE, Osawa Y, Lieberman AP. Inhibition of hsp70 by methylene blue affects signaling protein function and ubiquitination and modulates polyglutamine protein degradation. J Biol Chem. 2010 May 21; 285(21):15714-23. PMID: 20348093; PMCID: PMC2871437.
    89. Jinwal UK, O'Leary JC, Borysov SI, Jones JR, Li Q, Koren J, Abisambra JF, Vestal GD, Lawson LY, Johnson AG, Blair LJ, Jin Y, Miyata Y, Gestwicki JE, Dickey CA. Hsc70 rapidly engages tau after microtubule destabilization. J Biol Chem. 2010 May 28; 285(22):16798-805. PMID: 20308058; PMCID: PMC2878041.
    90. Gestwicki JE. Special series: Molecular chaperones in protein folding and disease. Biopolymers. 2010 Mar; 93(3):209-10. PMID: 20039372.
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    91. Koren J, Jinwal UK, Jin Y, O'Leary J, Jones JR, Johnson AG, Blair LJ, Abisambra JF, Chang L, Miyata Y, Cheng AM, Guo J, Cheng JQ, Gestwicki JE, Dickey CA. Facilitating Akt clearance via manipulation of Hsp70 activity and levels. J Biol Chem. 2010 Jan 22; 285(4):2498-505. PMID: 19889640; PMCID: PMC2807306.
    92. Jinwal UK, Miyata Y, Koren J, Jones JR, Trotter JH, Chang L, O'Leary J, Morgan D, Lee DC, Shults CL, Rousaki A, Weeber EJ, Zuiderweg ER, Gestwicki JE, Dickey CA. Chemical manipulation of hsp70 ATPase activity regulates tau stability. J Neurosci. 2009 Sep 30; 29(39):12079-88. PMID: 19793966; PMCID: PMC2775811.
    93. Reinke AA, Seh HY, Gestwicki JE. A chemical screening approach reveals that indole fluorescence is quenched by pre-fibrillar but not fibrillar amyloid-beta. Bioorg Med Chem Lett. 2009 Sep 1; 19(17):4952-7. PMID: 19640715; PMCID: PMC2730169.
    94. Marinec PS, Evans CG, Gibbons GS, Tarnowski MA, Overbeek DL, Gestwicki JE. Synthesis of orthogonally reactive FK506 derivatives via olefin cross metathesis. Bioorg Med Chem. 2009 Aug 15; 17(16):5763-8. PMID: 19643614; PMCID: PMC2758530.
    95. Evans CG, Gestwicki JE. Enantioselective organocatalytic Hantzsch synthesis of polyhydroquinolines. Org Lett. 2009 Jul 16; 11(14):2957-9. PMID: 19527003; PMCID: PMC2727599.
    96. Bertelsen EB, Chang L, Gestwicki JE, Zuiderweg ER. Solution conformation of wild-type E. coli Hsp70 (DnaK) chaperone complexed with ADP and substrate. Proc Natl Acad Sci U S A. 2009 May 26; 106(21):8471-6. PMID: 19439666; PMCID: PMC2689011.
    97. Lexa KW, Damm KL, Quintero JJ, Gestwicki JE, Carlson HA. Clarifying allosteric control of flap conformations in the 1TW7 crystal structure of HIV-1 protease. Proteins. 2009 Mar; 74(4):872-80. PMID: 18704936; PMCID: PMC2635929.
    98. Marinec PS, Chen L, Barr KJ, Mutz MW, Crabtree GR, Gestwicki JE. FK506-binding protein (FKBP) partitions a modified HIV protease inhibitor into blood cells and prolongs its lifetime in vivo. Proc Natl Acad Sci U S A. 2009 Feb 3; 106(5):1336-41. PMID: 19164520; PMCID: PMC2635806.
    99. Patury S, Geda P, Dobry CJ, Kumar A, Gestwicki JE. Conditional nuclear import and export of yeast proteins using a chemical inducer of dimerization. Cell Biochem Biophys. 2009; 53(3):127-34. PMID: 19159085.
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    100. Patury S, Miyata Y, Gestwicki JE. Pharmacological targeting of the Hsp70 chaperone. Curr Top Med Chem. 2009; 9(15):1337-51. PMID: 19860737; PMCID: PMC2799686.
    101. Geda P, Patury S, Ma J, Bharucha N, Dobry CJ, Lawson SK, Gestwicki JE, Kumar A. A small molecule-directed approach to control protein localization and function. Yeast. 2008 Aug; 25(8):577-94. PMID: 18668531.
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    102. Damm KL, Ung PM, Quintero JJ, Gestwicki JE, Carlson HA. A poke in the eye: inhibiting HIV-1 protease through its flap-recognition pocket. Biopolymers. 2008 Aug; 89(8):643-52. PMID: 18381626; PMCID: PMC2859825.
    103. Gestwicki JE. The interface of chemistry and biology is actually a continuum. ACS Chem Biol. 2008 Jun 20; 3(6):328-34. PMID: 18570351.
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    104. Marinec PS, Lancia JK, Gestwicki JE. Bifunctional molecules evade cytochrome P(450) metabolism by forming protective complexes with FK506-binding protein. Mol Biosyst. 2008 Jun; 4(6):571-8. PMID: 18493655.
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    105. Wisén S, Gestwicki JE. Identification of small molecules that modify the protein folding activity of heat shock protein 70. Anal Biochem. 2008 Mar 15; 374(2):371-7. PMID: 18191466.
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    106. Wisén S, Androsavich J, Evans CG, Chang L, Gestwicki JE. Chemical modulators of heat shock protein 70 (Hsp70) by sequential, microwave-accelerated reactions on solid phase. Bioorg Med Chem Lett. 2008 Jan 1; 18(1):60-5. PMID: 18060774.
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    107. Hadden MK, Galam L, Gestwicki JE, Matts RL, Blagg BS. Derrubone, an inhibitor of the Hsp90 protein folding machinery. J Nat Prod. 2007 Dec; 70(12):2014-8. PMID: 18020309.
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    108. Gestwicki JE, Marinec PS. Chemical control over protein-protein interactions: beyond inhibitors. Comb Chem High Throughput Screen. 2007 Sep; 10(8):667-75. PMID: 18045079.
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    109. Reinke AA, Gestwicki JE. Structure-activity relationships of amyloid beta-aggregation inhibitors based on curcumin: influence of linker length and flexibility. Chem Biol Drug Des. 2007 Sep; 70(3):206-15. PMID: 17718715.
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    110. Chang L, Bertelsen EB, Wisén S, Larsen EM, Zuiderweg ER, Gestwicki JE. High-throughput screen for small molecules that modulate the ATPase activity of the molecular chaperone DnaK. Anal Biochem. 2008 Jan 15; 372(2):167-76. PMID: 17904512.
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    111. Stankunas K, Bayle JH, Havranek JJ, Wandless TJ, Baker D, Crabtree GR, Gestwicki JE. Rescue of degradation-prone mutants of the FK506-rapamycin binding (FRB) protein with chemical ligands. Chembiochem. 2007 Jul 9; 8(10):1162-9. PMID: 17525916.
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    112. Rubinsztein DC, Gestwicki JE, Murphy LO, Klionsky DJ. Potential therapeutic applications of autophagy. Nat Rev Drug Discov. 2007 Apr; 6(4):304-12. PMID: 17396135.
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    113. Evans CG, Wisén S, Gestwicki JE. Heat shock proteins 70 and 90 inhibit early stages of amyloid beta-(1-42) aggregation in vitro. J Biol Chem. 2006 Nov 3; 281(44):33182-91. PMID: 16973602.
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    114. Gestwicki JE. Reclamation of proteins from the cellular scrap heap. ACS Chem Biol. 2006 May 23; 1(4):201-3. PMID: 17163671.
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    115. Kiessling LL, Gestwicki JE, Strong LE. Synthetic multivalent ligands as probes of signal transduction. Angew Chem Int Ed Engl. 2006 Apr 3; 45(15):2348-68. PMID: 16557636; PMCID: PMC2842921.
    116. Bayle JH, Grimley JS, Stankunas K, Gestwicki JE, Wandless TJ, Crabtree GR. Rapamycin analogs with differential binding specificity permit orthogonal control of protein activity. Chem Biol. 2006 Jan; 13(1):99-107. PMID: 16426976.
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    117. Bose M, Gestwicki JE, Devasthali V, Crabtree GR, Graef IA. 'Nature-inspired' drug-protein complexes as inhibitors of Abeta aggregation. Biochem Soc Trans. 2005 Aug; 33(Pt 4):543-7. PMID: 16042540.
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    118. Gestwicki JE. Target identification for a promising anti-lupus drug. Chem Biol. 2005 Apr; 12(4):414-5. PMID: 15850977.
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    119. Gestwicki JE, Crabtree GR, Graef IA. Harnessing chaperones to generate small-molecule inhibitors of amyloid beta aggregation. Science. 2004 Oct 29; 306(5697):865-9. PMID: 15514157.
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    120. Chang CP, Neilson JR, Bayle JH, Gestwicki JE, Kuo A, Stankunas K, Graef IA, Crabtree GR. A field of myocardial-endocardial NFAT signaling underlies heart valve morphogenesis. Cell. 2004 Sep 3; 118(5):649-63. PMID: 15339668.
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    121. Stankunas K, Bayle JH, Gestwicki JE, Lin YM, Wandless TJ, Crabtree GR. Conditional protein alleles using knockin mice and a chemical inducer of dimerization. Mol Cell. 2003 Dec; 12(6):1615-24. PMID: 14690613.
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    122. Gestwicki JE, Cairo CW, Borrok MJ, Kiessling LL. Visualization and characterization of receptor clusters by transmission electron microscopy. Methods Enzymol. 2003; 362:301-12. PMID: 12968372.
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    123. Gestwicki JE, Cairo CW, Strong LE, Oetjen KA, Kiessling LL. Influencing receptor-ligand binding mechanisms with multivalent ligand architecture. J Am Chem Soc. 2002 Dec 18; 124(50):14922-33. PMID: 12475334.
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    124. Lamanna AC, Gestwicki JE, Strong LE, Borchardt SL, Owen RM, Kiessling LL. Conserved amplification of chemotactic responses through chemoreceptor interactions. J Bacteriol. 2002 Sep; 184(18):4981-7. PMID: 12193613; PMCID: PMC135308.
    125. Owen RM, Gestwicki JE, Young T, Kiessling LL. Synthesis and applications of end-labeled neoglycopolymers. Org Lett. 2002 Jul 11; 4(14):2293-6. PMID: 12098230.
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    126. Gestwicki JE, Cairo CW, Mann DA, Owen RM, Kiessling LL. Selective immobilization of multivalent ligands for surface plasmon resonance and fluorescence microscopy. Anal Biochem. 2002 Jun 15; 305(2):149-55. PMID: 12054443.
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    127. Cairo CW, Gestwicki JE, Kanai M, Kiessling LL. Control of multivalent interactions by binding epitope density. J Am Chem Soc. 2002 Feb 27; 124(8):1615-9. PMID: 11853434.
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    128. Gestwicki JE, Strong LE, Cairo CW, Boehm FJ, Kiessling LL. Cell aggregation by scaffolded receptor clusters. Chem Biol. 2002 Feb; 9(2):163-9. PMID: 11880031.
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    129. Gestwicki JE, Kiessling LL. Inter-receptor communication through arrays of bacterial chemoreceptors. Nature. 2002 Jan 3; 415(6867):81-4. PMID: 11780121.
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    130. Gestwicki JE, Hsieh HV, Pitner JB. Using receptor conformational change to detect low molecular weight analytes by surface plasmon resonance. Anal Chem. 2001 Dec 1; 73(23):5732-7. PMID: 11774914.
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    131. Gestwicki JE, Strong LE, Borchardt SL, Cairo CW, Schnoes AM, Kiessling LL. Designed potent multivalent chemoattractants for Escherichia coli. Bioorg Med Chem. 2001 Sep; 9(9):2387-93. PMID: 11553480.
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    132. Gestwicki JE, Strong LE, Kiessling LL. Visualization of Single Multivalent Receptor-Ligand Complexes by Transmission Electron Microscopy The authors thank Colleen Lavin (UW Madison, Microscopy Resource) and Kim Dickson for experimental support. This work was supported in part by the NIH (GM 55984). J.E.G. acknowledges the NIH Biotechnology Training Grant for support (T32GM08349). L.E.S. was supported by an NIH predoctoral fellowship (GM 18750). Angew Chem Int Ed Engl. 2000 Dec 15; 39(24):4567-4570. PMID: 11169672.
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    133. Kiessling LL, Gestwicki JE, Strong LE. Synthetic multivalent ligands in the exploration of cell-surface interactions. Curr Opin Chem Biol. 2000 Dec; 4(6):696-703. PMID: 11102876.
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    134. Gestwicki JE, Lamanna AC, Harshey RM, McCarter LL, Kiessling LL, Adler J. Evolutionary conservation of methyl-accepting chemotaxis protein location in Bacteria and Archaea. J Bacteriol. 2000 Nov; 182(22):6499-502. PMID: 11053396; PMCID: PMC94798.
    135. Hoag KA, Clise-Dwyer K, Lim YH, Nashold FE, Gestwicki J, Cancro MP, Hayes CE. A quantitative-trait locus controlling peripheral B-cell deficiency maps to mouse Chromosome 15. Immunogenetics. 2000 Sep; 51(11):924-9. PMID: 11003386.
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    136. Maki N, Gestwicki JE, Lake EM, Kiessling LL, Adler J. Motility and chemotaxis of filamentous cells of Escherichia coli. J Bacteriol. 2000 Aug; 182(15):4337-42. PMID: 10894745; PMCID: PMC101954.
    137. Gestwicki JE, Strong LE, Kiessling LL. Tuning chemotactic responses with synthetic multivalent ligands. Chem Biol. 2000 Aug; 7(8):583-91. PMID: 11048949.
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    138. Kabza KG, Chapados BR, Gestwicki JE, McGrath JL. Microwave-induced esterification using heterogeneous acid catalyst in a low dielectric constant medium J Org Chem. 2000 Feb 25; 65(4):1210-4. PMID: 10814074.
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    139. Gordon EJ, Gestwicki JE, Strong LE, Kiessling LL. Synthesis of end-labeled multivalent ligands for exploring cell-surface-receptor-ligand interactions. Chem Biol. 2000 Jan; 7(1):9-16. PMID: 10662681.
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