Steve Braunstein, MD, PhD

Address505 Parnassus Ave, Long
San Francisco CA 94117
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    Collapse Biography 
    Collapse education and training
    New York University School of MedicineMD,PhD2009Medicine, Microbiology
    Brigham and Women's Hospital/DFCIInternship2010Internal Medicine
    UCSFResidency2014Radiation Oncology
    Collapse Awards and Honors
    UCSF2013Exceptional Physician Award

    Collapse Overview 
    Collapse overview
    Dr. Braunstein is a radiation oncologist with a clinical interest in the treatment of pediatric, central nervous system, and soft tissue malignancies. He has expertise in modern radiation therapy techniques including stereotactic radiotherapy (Gamma Knife, Cyberknife, Linac-based SBRT), intraoperative radiotherapy, and intensity modulated radiation therapy.

    Dr. Braunstein earned his M.D. at New York University School of Medicine where he also obtained a Ph.D. studying essential molecular pathways by which cancer cells mediate response to radiation. He completed residency at UCSF in 2014, during which time he continued to study cancer cell response to radiation, investigating genetic polymorphisms which yield the observed heterogeneity of tumor cell population radiosensitivity and risk of radiation-related secondary cancer.

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    Collapse Bibliographic 
    Collapse Selected Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Sperduto PW, Yang TJ, Beal K, Pan H, Brown PD, Bangdiwala A, Shanley R, Yeh N, Gaspar LE, Braunstein S, Sneed P, Boyle J, Kirkpatrick JP, Mak KS, Shih HA, Engelman A, Roberge D, Arvold ND, Alexander B, Awad MM, Contessa J, Chiang V, Hardie J, Ma D, Lou E, Sperduto W, Mehta MP. Estimating Survival in Patients With Lung Cancer and Brain Metastases: An Update of the Graded Prognostic Assessment for Lung Cancer Using Molecular Markers (Lung-molGPA). JAMA Oncol. 2016 Nov 17. PMID: 27892978.
      View in: PubMed
    2. Verma V, Simone CB, Allen PK, Gajjar SR, Shah C, Zhen W, Harkenrider MM, Hallemeier CL, Jabbour SK, Matthiesen CL, Braunstein SE, Lee P, Dilling TJ, Allen BG, Nichols EM, Attia A, Zeng J, Biswas T, Paximadis P, Wang F, Walker JM, Stahl JM, Daly ME, Decker RH, Hales RK, Willers H, Videtic GM, Mehta MP, Lin SH. Multi-Institutional Experience of Stereotactic Ablative Radiation Therapy for Stage I Small Cell Lung Cancer. Int J Radiat Oncol Biol Phys. 2016 Nov 02. PMID: 28011047.
      View in: PubMed
    3. Chiu J, Pierce M, Braunstein SE, Theodosopoulos PV, McDermott MW, Sneed PK, Ma L. Sharpening peripheral dose gradient via beam number enhancement from patient head tilt for stereotactic brain radiosurgery. Phys Med Biol. 2016 Oct 03; 61(20):N532-N541. PMID: 27694708.
      View in: PubMed
    4. Magnuson WJ, Amini A, Patil T, Kavanagh BD, Camidge DR, Braunstein S, Boreta L, Attia A, Rana N, Contessa JN, Gettinger SN, Lester-Coll NH, Yu JB, Chiang VL, et al. Deferring Radiation Therapy for Brain Metastases in Patients With EGFR-Mutant Non-Small Cell Lung Cancer: A Multi-Institutional Analysis. Int J Radiat Oncol Biol Phys. 2016 Oct 1; 96(2S):S57-S58. PMID: 27675963.
      View in: PubMed
    5. Raleigh D, Tomlin B, Del Buono B, Roddy E, Sear K, Byer L, Felton E, Banerjee A, Torkildson J, Samuel D, Horn B, Braunstein S, Haas-Kogan DA, Mueller S, et al. High-Dose Chemotherapy With Stem Cell Transplant to Delay Craniospinal Irradiation in Pediatric Embryonal Brain Tumor Patients. Int J Radiat Oncol Biol Phys. 2016 Oct 1; 96(2S):S231. PMID: 27675857.
      View in: PubMed
    6. McTyre E, Ayala-Peacock DN, Contessa JN, Chung C, Fiveash JB, Ahluwalia M, Kotecha R, Chao ST, Attia A, Hepel JT, Braunstein S, Chan MD, et al. Multi-Institutional Competing Risks Analysis Predicting Distant Brain Failure and Salvage Patterns After Upfront Radiosurgery Without Whole-Brain Radiation Therapy for Brain Metastasis. Int J Radiat Oncol Biol Phys. 2016 Oct 1; 96(2S):S180-S181. PMID: 27675725.
      View in: PubMed
    7. Sperduto PW, Jiang W, Brown PD, Braunstein S, Sneed PK, Wattson DA, Shih HA, Bangdiwala A, Shanley R, Lockney NA, Beal K, Lou E, Amatruda T, Sperduto WA, Kirkpatrick JP, Yeh N, Gaspar LE, Molitoris JK, Masucci L, Roberge D, Yu JB, Chiang VL, Mehta MP, et al. The Effect of Gene Mutations on Survival in Patients With Melanoma Following the Development of Brain Metastases. Int J Radiat Oncol Biol Phys. 2016 Oct 1; 96(2S):S178. PMID: 27675718.
      View in: PubMed
    8. Ma L, Braunstein S, Theodosopoulos P, McDermott MW, Sneed PK, et al. Inherent Functional Dependence Among Cochlear Dose Surrogates for Stereotactic Radiosurgery of Acoustic Schwannomas. Int J Radiat Oncol Biol Phys. 2016 Oct 1; 96(2S):E81-E82. PMID: 27675473.
      View in: PubMed
    9. Garcia MA, Fogh SE, Anderson W, Hertan LM, Balboni TA, Haas-Kogan DA, Braunstein S, et al. Pain Assessment at Radiation Oncology Consultation for Bone Metastases. Int J Radiat Oncol Biol Phys. 2016 Oct 1; 96(2S):E514-E515. PMID: 27674895.
      View in: PubMed
    10. Kauffmann G, Gunther JR, Braunstein S, Hara W, Spektor A, Brower JV, Stahl JM, Rao YJ, Vargo J, Ye JC, Fields EC, Thomas CR, Du KL, Kruser TJ, Jimenez RB, Hirsch AE, Currey AD, Yechieli R, Mohindra P, Golden DW, et al. Updated Analysis of a Multi-Institutional Radiation Oncology Clerkship Curriculum: A Report From the Radiation Oncology Education Collaborative Study Group. Int J Radiat Oncol Biol Phys. 2016 Oct 1; 96(2S):E412. PMID: 27674624.
      View in: PubMed
    11. Singer L, Boreta L, Braunstein S, Fogh SE, et al. A Quality Improvement Study to Improve Assessment of Patient Readiness to Quit Tobacco Prior to Treatment With Radiation Therapy. Int J Radiat Oncol Biol Phys. 2016 Oct 1; 96(2S):E408. PMID: 27674611.
      View in: PubMed
    12. Braunstein S, Garcia MA, Xu C, et al. Influence of Molecular Subgroups and Systemic Therapy on Outcomes of Metastatic Breast Cancer Patients Receiving Stereotactic Radiosurgery for Brain Metastases. Int J Radiat Oncol Biol Phys. 2016 Oct 1; 96(2S):E134. PMID: 27673865.
      View in: PubMed
    13. Yu Y, Garcia MA, Braunstein S, Sneed PK, et al. Patterns of Failure after Adjuvant Radiosurgery for Surgically Resected Brain Metastases: Surgical Tract Failures and Implications for Target Delineation. Int J Radiat Oncol Biol Phys. 2016 Oct 1; 96(2S):E130. PMID: 27673856.
      View in: PubMed
    14. Paulsson AK, Garcia MA, Tinkle CL, Nakamura JL, Fogh SE, Sneed PK, Braunstein S, et al. The Impact of Targeted Therapy and Immunotherapy on Melanoma Brain Metastases Treated With Stereotactic Radiosurgery. Int J Radiat Oncol Biol Phys. 2016 Oct 1; 96(2S):E108. PMID: 27673798.
      View in: PubMed
    15. Ma L, Braunstein SE, Theodosopoulos PV, McDermott MW, Sneed PK. Inherent functional dependence among cochlear dose surrogates for stereotactic radiosurgery of vestibular schwannomas. Pract Radiat Oncol. 2016 Aug 20. PMID: 27742557.
      View in: PubMed
    16. Sperduto PW, Yang TJ, Beal K, Pan H, Brown PD, Bangdiwala A, Shanley R, Yeh N, Gaspar LE, Braunstein S, Sneed P, Boyle J, Kirkpatrick JP, Mak KS, Shih HA, Engelman A, Roberge D, Arvold ND, Alexander B, Awad MM, Contessa J, Chiang V, Hardie J, Ma D, Lou E, Sperduto W, Mehta MP. The Effect of Gene Alterations and Tyrosine Kinase Inhibition on Survival and Cause of Death in Patients With Adenocarcinoma of the Lung and Brain Metastases. Int J Radiat Oncol Biol Phys. 2016 Oct 1; 96(2):406-13. PMID: 27598807.
      View in: PubMed
    17. Ye JC, Thomas CR, Braunstein S, Hirsch AE, Gunther JR, Golden DW. In Regard to Ahmed et al. Int J Radiat Oncol Biol Phys. 2016 Apr 1; 94(5):1221-2. PMID: 27026323.
      View in: PubMed
    18. Held M, Cremers F, Sneed PK, Braunstein S, Fogh SE, Nakamura J, Barani I, Perez-Andujar A, Pouliot J, Morin O. Assessment of image quality and dose calculation accuracy on kV CBCT, MV CBCT, and MV CT images for urgent palliative radiotherapy treatments. J Appl Clin Med Phys. 2016; 17(2):6040. PMID: 27074487.
      View in: PubMed
    19. Imber BS, Braunstein SE, Wu FY, Nabavizadeh N, Boehling N, Weinberg VK, Tihan T, Barnes M, Mueller S, Butowski NA, Clarke JL, Chang SM, McDermott MM, Prados MD, Berger MS, Haas-Kogan DA. Clinical outcome and prognostic factors for central neurocytoma: twenty year institutional experience. J Neurooncol. 2016 Jan; 126(1):193-200. PMID: 26493740.
      View in: PubMed
    20. Singer L, Braunstein S, Fogh SE. Looking Ahead: Practicing Radiation Oncology in the Era of ICD-10. Int J Radiat Oncol Biol Phys. 2015 Dec 1; 93(5):949-52. PMID: 26581130.
      View in: PubMed
    21. Golden DW, Braunstein S, Jimenez RB, Mohindra P, Spektor A, Ye JC. Multi-Institutional Implementation and Evaluation of a Curriculum for the Medical Student Clerkship in Radiation Oncology. J Am Coll Radiol. 2016 Feb; 13(2):203-9. PMID: 26410347; PMCID: PMC4744090 [Available on 02/01/17].
    22. Tinkle CL, Weinberg V, Braunstein SE, Wustrack R, Horvai A, Jahan T, O'Donnell RJ, Gottschalk AR. Intraoperative Radiotherapy in the Management of Locally Recurrent Extremity Soft Tissue Sarcoma. Sarcoma. 2015; 2015:913565. PMID: 26346118; PMCID: PMC4546758.
    23. Raleigh DR, Chang AJ, Tomlin B, Cunha JA, Braunstein S, Shinohara K, Gottschalk AR, Roach M, Hsu IC. Patient- and treatment-specific predictors of genitourinary function after high-dose-rate monotherapy for favorable prostate cancer. Brachytherapy. 2015 Nov-Dec; 14(6):795-800. PMID: 26198421.
      View in: PubMed
    24. Mroue R, Huang B, Braunstein S, Firestone AJ, Nakamura JL. Correction: Monoallelic Loss of the Imprinted Gene Grb10 Promotes Tumor Formation in Irradiated Nf1+/- Mice. PLoS Genet. 2015 Jun; 11(6):e1005327. PMID: 26075392; PMCID: PMC4468248.
    25. Mroue R, Huang B, Braunstein S, Firestone AJ, Nakamura JL. Monoallelic loss of the imprinted gene Grb10 promotes tumor formation in irradiated Nf1+/- mice. PLoS Genet. 2015 May; 11(5):e1005235. PMID: 26000738; PMCID: PMC4441450.
    26. Seymour ZA, Fogh SE, Westcott SK, Braunstein S, Larson DA, Barani IJ, Nakamura J, Sneed PK. Interval From Imaging to Treatment Delivery in the Radiation Surgery Age: How Long Is Too Long? Int J Radiat Oncol Biol Phys. 2015 Sep 1; 93(1):126-32. PMID: 26279030.
      View in: PubMed
    27. Raleigh DR, Hsu IC, Braunstein S, Chang AJ, Simko JP, Roach M. Bladder wall recurrence of prostate cancer after high-dose-rate brachytherapy. Brachytherapy. 2015 Mar-Apr; 14(2):185-8. PMID: 25533416.
      View in: PubMed
    28. Chen CP, Braunstein S, Mourad M, Hsu IC, Haas-Kogan D, Roach M, Fogh SE. Quality improvement of International Classification of Diseases, 9th revision, diagnosis coding in radiation oncology: single-institution prospective study at University of California, San Francisco. Pract Radiat Oncol. 2015 Jan-Feb; 5(1):e45-51. PMID: 25413428.
      View in: PubMed
    29. Braunstein S, Nakamura JL. Radiotherapy-induced malignancies: review of clinical features, pathobiology, and evolving approaches for mitigating risk. Front Oncol. 2013; 3:73. PMID: 23565507; PMCID: PMC3615242.
    30. Nie K, Chuang C, Kirby N, Braunstein S, Pouliot J. Site-specific deformable imaging registration algorithm selection using patient-based simulated deformations. Med Phys. 2013 Apr; 40(4):041911. PMID: 23556905.
      View in: PubMed
    31. Badura M, Braunstein S, Zavadil J, Schneider RJ. DNA damage and eIF4G1 in breast cancer cells reprogram translation for survival and DNA repair mRNAs. Proc Natl Acad Sci U S A. 2012 Nov 13; 109(46):18767-72. PMID: 23112151; PMCID: PMC3503184.
    32. Choi G, Huang B, Pinarbasi E, Braunstein SE, Horvai AE, Kogan S, Bhatia S, Faddegon B, Nakamura JL. Genetically mediated Nf1 loss in mice promotes diverse radiation-induced tumors modeling second malignant neoplasms. Cancer Res. 2012 Dec 15; 72(24):6425-34. PMID: 23071067; PMCID: PMC3787120.
    33. Ramírez-Valle F, Badura ML, Braunstein S, Narasimhan M, Schneider RJ. Mitotic raptor promotes mTORC1 activity, G(2)/M cell cycle progression, and internal ribosome entry site-mediated mRNA translation. Mol Cell Biol. 2010 Jul; 30(13):3151-64. PMID: 20439490; PMCID: PMC2897579.
    34. Braunstein S, Badura ML, Xi Q, Formenti SC, Schneider RJ. Regulation of protein synthesis by ionizing radiation. Mol Cell Biol. 2009 Nov; 29(21):5645-56. PMID: 19704005; PMCID: PMC2772731.
    35. Matsumura S, Wang B, Kawashima N, Braunstein S, Badura M, Cameron TO, Babb JS, Schneider RJ, Formenti SC, Dustin ML, Demaria S. Radiation-induced CXCL16 release by breast cancer cells attracts effector T cells. J Immunol. 2008 Sep 1; 181(5):3099-107. PMID: 18713980; PMCID: PMC2587101.
    36. Ramírez-Valle F, Braunstein S, Zavadil J, Formenti SC, Schneider RJ. eIF4GI links nutrient sensing by mTOR to cell proliferation and inhibition of autophagy. J Cell Biol. 2008 Apr 21; 181(2):293-307. PMID: 18426977; PMCID: PMC2315676.
    37. Braunstein S, Formenti SC, Schneider RJ. Acquisition of stable inducible up-regulation of nuclear factor-kappaB by tumor necrosis factor exposure confers increased radiation resistance without increased transformation in breast cancer cells. Mol Cancer Res. 2008 Jan; 6(1):78-88. PMID: 18234964.
      View in: PubMed
    38. Braunstein S, Karpisheva K, Pola C, Goldberg J, Hochman T, Yee H, Cangiarella J, Arju R, Formenti SC, Schneider RJ. A hypoxia-controlled cap-dependent to cap-independent translation switch in breast cancer. Mol Cell. 2007 Nov 9; 28(3):501-12. PMID: 17996713.
      View in: PubMed
    39. Oxelmark E, Roth JM, Brooks PC, Braunstein SE, Schneider RJ, Garabedian MJ. The cochaperone p23 differentially regulates estrogen receptor target genes and promotes tumor cell adhesion and invasion. Mol Cell Biol. 2006 Jul; 26(14):5205-13. PMID: 16809759; PMCID: PMC1592714.
    40. Connolly E, Braunstein S, Formenti S, Schneider RJ. Hypoxia inhibits protein synthesis through a 4E-BP1 and elongation factor 2 kinase pathway controlled by mTOR and uncoupled in breast cancer cells. Mol Cell Biol. 2006 May; 26(10):3955-65. PMID: 16648488; PMCID: PMC1489005.
    41. Kim SS, Zhang RG, Braunstein SE, Joachimiak A, Cvekl A, Hegde RS. Structure of the retinal determination protein Dachshund reveals a DNA binding motif. Structure. 2002 Jun; 10(6):787-95. PMID: 12057194.
      View in: PubMed
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