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    Tejal Desai, PhD

    TitleProfessor
    SchoolUCSF School of Pharmacy
    DepartmentBioengineering
    Address1700 4th Street
    San Francisco CA 94158
    Phone415-514-4503

       Biography 
       Education and Training
      Institution Degree School or Department Year
      University of California, San FranciscoPh.D. Graduate Division (Bioengineering)1998
       Awards and Honors
      Sigma Xi, Scientific Honor Society1994Member
      University of California, San Francisco1994Fellowship of the Regents
      National Science Foundation1995Graduate Fellowship Recipient
      Whitaker Foundation1995Graduate Fellowship in Biomedical Engineering
      University of California, San Francisco1997Graduate Conference Presentation Award
      University of California, San Francisco1997Graduate Dissertation Research Award
      University of California, San Francisco1997Graduate Students Association Travel Award
      Crain's Chicago Business1998Who's Who among America's Teachers
      Crain's Chicago Business199940 Under 40 Award: For Leadership and Innovation
      Technology Review Magazine's Top 100 Young Innovators1999MIT's TR100 Award
      University of Illinois, Chicago, College of Engineering2000Award of Distinction
      National Science Foundation2000CAREER Award
      University of Illinois, Chicago, College of Engineering2000Best Advisor Award
      National Science Foundation2000New Century Scholar Award
      BioMEMS and Nanotechnology Society2001Visionary Science Award
      Frontiers in Engineering, National Academy of Engineering2001Invited Participant
      Johnson and Johnson2002Focused Giving Award
      McGowan Institute2002Award for Contributions to Regenerative Medicine
      EURAND2003Grand Prize Award for Outstanding Research in Oral Drug Delivery
      Massachusetts Institute of Technology2003Globus Indus Technovator Award
      Popular Science2003"Brilliant 10" Top Scientists in the Nation
      Whitaker Leadership Conference2003Invited Conference Participant
      INDIA New England2004Woman of the Year
      World Technology Award2004Award Finalist in Health and Medicine
      Capsugel/Pfizer2004Innovative Aspects of Oral Drug Delivery Award (Paper Competition)
      National Academy of Engineering2004Invited Participant: Keck Futures Initiative: Designing Nanostructure
      INDUS2004Winner of INDUS Top 15
      Women in Engineering Leadership Conference2005Nomination and Award
      Siemens National Competition2005Judge in Nanotechnology
      Lawrence Hall of Science2005Featured Exhibit, Women in Nanotechnology
      EURAND2006Grand Prize Award for Innovative Approaches to Drug Delivery
      2006Rogers Bridging the Gap Award for New Technologies
      University of California, Berkeley2006Distinguished Engineering Alumni Award
      University of California, San Francisco, UCSF/CORO2007Faculty Leadership Collaborative
      Capsugel/Pfizer2007Innovative Aspects of Oral Drug Delivery Award (Two Paper Awards)
      Engineering in Medicine and Biology Society (EMBS)2007Career Award
      7 x 7 Magazine2008San Francisco's Top 40 under 40
      Diversity in Higher Education Journal2008Emerging Scholar Award
      Controlled Release Society2009Awards for Best Papers (Oral and Pharmaceutical Categories)
      IEEE Society2009Senior Member
      Siemens Math, Science, and Technology Competition2009National Judge
      Nature Medicine's 5 Big Ideas for Nanotechnology2009Work Cited
      NIH Biomaterials and Biointerfaces Study Section2010Standing Member
      University of California, San Francisco2010Dean's Citation for Excellence in Teaching
      American Insitute of Medical and Biological Engineering (AIMBE)2011Elected Fellow of American Insitute of Medical and Biological Engineering (AIMBE)
      Wallace H. Coulter Foundation2011Translational Award Recipient
      Whitaker International Scholars2011Review Committee
      Siemens National Competition2011Nanotechnology Judge
      American Association of Colleges of Pharmacy2012Paul Dawson Biotechnology Award
      Invited Participant2013OME Precision Medicine Summit
      Whitaker International Scholars Programs2013Steering Committee
      Scientific American2013Featured Innovator
      Invited Participant2013McKinsey's 3rd Annual Women's Leadership Summit
      Appointed Chair2014Biomaterial and Biointerfaces NIH Study Section

       Overview 
       Overview
      Dr. Desai’s research brings together advanced micro and nanotechnologies, fundamental insight into cellular behavior in engineered environments, and novel pharmacologic delivery approaches to address disease treatment and clinical translation. Currently, her laboratory focuses on four highly interdisciplinary directions: 1. Hierarchical devices for enhanced cellular adhesion and paracellular drug transport; 2. Injectable and flexible nanoporous devices for rate-controlled long term release of therapeutics; 3. Nanostructured coatings and scaffolds for pro-healing implants and in vivo modulation of fibrosis, and 4. Cell-based delivery platforms for autoimmune disease applications. She envisions a future of precision medicine, enabled by advances in nanotechnology, engineering, and cell biology directed to clinical challenges in disease treatment. By taking advantage of our understanding of how cells respond to engineered materials and our ability to fabricate precise structural domains, her lab seeks to design new platforms to overcome existing challenges in therapeutic delivery.

       Interests
      Nanostructured materials, BioMEMS and Biomedical Nanotechnology, bioengineering, drug delivery (Oral, Ocular, and Implantable), cell encapsulation technologies (Pancreatic and Neurosecretory), tissue engineering (Cardiovascular, Retinal, Corneal, and Bone), three dimensional scaffold and matrix fabrication, medical devices, surface modification and biocompatibility

       ORNG Applications 
       Websites
       Featured Videos
       In The News
       Faculty Mentoring
       NIH Grants Awarded
       Global Health
       Twitter
       More Info

       Bibliographic 
       Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Doroudian G, Pinney J, Ayala P, Los T, Desai TA, Russell B. Sustained delivery of MGF peptide from microrods attracts stem cells and reduces apoptosis of myocytes. Biomed Microdevices. 2014 Oct; 16(5):705-15.
        View in: PubMed
      2. Lee PP, Cerchiari A, Desai TA. Nitinol-based nanotubular coatings for the modulation of human vascular cell function. Nano Lett. 2014 Sep 10; 14(9):5021-8.
        View in: PubMed
      3. Wade JS, Desai TA. Planar microdevices enhance transport of large molecular weight molecules across retinal pigment epithelial cells. Biomed Microdevices. 2014 Aug; 16(4):629-38.
        View in: PubMed
      4. Pinney JR, Melkus G, Cerchiari A, Hawkins J, Desai TA. Novel functionalization of discrete polymeric biomaterial microstructures for applications in imaging and three-dimensional manipulation. ACS Appl Mater Interfaces. 2014 Aug 27; 6(16):14477-85.
        View in: PubMed
      5. Uskokovic V, Desai TA. Does Translational Symmetry Matter on the Micro Scale? Fibroblastic and Osteoblastic Interactions with the Topographically Distinct Poly(e-caprolactone)/Hydroxyapatite Thin Films. ACS Appl Mater Interfaces. 2014 Aug 13; 6(15):13209-20.
        View in: PubMed
      6. Pinney JR, Du KT, Ayala P, Fang Q, Sievers RE, Chew P, Delrosario L, Lee RJ, Desai TA. Discrete microstructural cues for the attenuation of fibrosis following myocardial infarction. Biomaterials. 2014 Oct; 35(31):8820-8.
        View in: PubMed
      7. Muthusubramaniam L, Zaitseva T, Paukshto M, Martin G, Desai T. Effect of collagen nanotopography on keloid fibroblast proliferation and matrix synthesis: Implications for dermal wound healing. Tissue Eng Part A. 2014 Apr 11.
        View in: PubMed
      8. Chirra HD, Shao L, Ciaccio N, Fox CB, Wade JM, Ma A, Desai TA. Planar Microdevices for Enhanced In Vivo Retention and Oral Bioavailability of Poorly Permeable Drugs. Adv Healthc Mater. 2014 Apr 7.
        View in: PubMed
      9. Schweicher J, Desai TA. Facile Synthesis of Robust Free-Standing TiO2 Nanotubular Membranes for Biofiltration Applications. J Appl Electrochem. 2014 Mar 1; 44(3):411-418.
        View in: PubMed
      10. Nyitray CE, Chavez MG, Desai TA. Compliant 3D Microenvironment Improves ß-Cell Cluster Insulin Expression Through Mechanosensing and ß-Catenin Signaling. Tissue Eng Part A. 2014 Feb 24.
        View in: PubMed
      11. Uskokovic V, Desai TA. Simultaneous bactericidal and osteogenic effect of nanoparticulate calcium phosphate powders loaded with clindamycin on osteoblasts infected with Staphylococcus aureus. Mater Sci Eng C Mater Biol Appl. 2014 Apr 1; 37:210-22.
        View in: PubMed
      12. Kurpinski K, Johnson T, Kumar S, Desai T, Li S. Mastering translational medicine: interdisciplinary education for a new generation. Sci Transl Med. 2014 Jan 8; 6(218):218fs2.
        View in: PubMed
      13. Schweicher J, Nyitray C, Desai TA. Membranes to achieve immunoprotection of transplanted islets. Front Biosci (Landmark Ed). 2014; 19:49-76.
        View in: PubMed
      14. Calvert KL, Desai T, Webster TJ. Advances in calcium phosphate coatings - anodic spark deposition: a review. Front Biosci (Landmark Ed). 2014; 19:475-89.
        View in: PubMed
      15. Fox CB, Chirra HD, Desai TA. Planar bioadhesive microdevices: a new technology for oral drug delivery. Curr Pharm Biotechnol. 2014; 15(7):673-83.
        View in: PubMed
      16. Uskokovic V, Desai TA. In vitro analysis of nanoparticulate hydroxyapatite/chitosan composites as potential drug delivery platforms for the sustained release of antibiotics in the treatment of osteomyelitis. J Pharm Sci. 2014 Feb; 103(2):567-79.
        View in: PubMed
      17. Kam KR, Walsh LA, Bock SM, Ollerenshaw JD, Ross RF, Desai TA. The effect of nanotopography on modulating protein adsorption and the fibrotic response. Tissue Eng Part A. 2014 Jan; 20(1-2):130-8.
        View in: PubMed
      18. Desai TA, Uskokovic V. Calcium phosphate nanoparticles: a future therapeutic platform for the treatment of osteomyelitis? Ther Deliv. 2013 Jun; 4(6):643-5.
        View in: PubMed
      19. Uskokovic V, Hoover C, Vukomanovic M, Uskokovic DP, Desai TA. Osteogenic and antimicrobial nanoparticulate calcium phosphate and poly-(D,L-lactide-co-glycolide) powders for the treatment of osteomyelitis. Mater Sci Eng C Mater Biol Appl. 2013 Aug 1; 33(6):3362-73.
        View in: PubMed
      20. Uskokovic V, Batarni SS, Schweicher J, King A, Desai TA. Effect of calcium phosphate particle shape and size on their antibacterial and osteogenic activity in the delivery of antibiotics in vitro. ACS Appl Mater Interfaces. 2013 Apr 10; 5(7):2422-31.
        View in: PubMed
      21. Koulajian K, Desai T, Liu GC, Ivovic A, Patterson JN, Tang C, El-Benna J, Joseph JW, Scholey JW, Giacca A. NADPH oxidase inhibition prevents beta cell dysfunction induced by prolonged elevation of oleate in rodents. Diabetologia. 2013 May; 56(5):1078-87.
        View in: PubMed
      22. Bernards DA, Bhisitkul RB, Wynn P, Steedman MR, Lee OT, Wong F, Thoongsuwan S, Desai TA. Ocular biocompatibility and structural integrity of micro- and nanostructured poly(caprolactone) films. J Ocul Pharmacol Ther. 2013 Mar; 29(2):249-57.
        View in: PubMed
      23. Silvestrini MT, Yin D, Coppes VG, Mann P, Martin AJ, Larson PS, Starr PA, Gupta N, Panter SS, Desai TA, Lim DA. Radially branched deployment for more efficient cell transplantation at the scale of the human brain. Stereotact Funct Neurosurg. 2013; 91(2):92-103.
        View in: PubMed
      24. Kam KR, Desai TA. Nano- and microfabrication for overcoming drug delivery challenges. J Mater Chem B Mater Biol Med. 2013; 1(14):1878-1884.
        View in: PubMed
      25. Kam KR, Walsh LA, Bock SM, Koval M, Fischer KE, Ross RF, Desai TA. Nanostructure-mediated transport of biologics across epithelial tissue: enhancing permeability via nanotopography. Nano Lett. 2013 Jan 9; 13(1):164-71.
        View in: PubMed
      26. Desai T. In the spotlight: Tissue engineering. IEEE Rev Biomed Eng. 2013; 6:27-8.
        View in: PubMed
      27. Uskokovic V, Desai TA. Phase composition control of calcium phosphate nanoparticles for tunable drug delivery kinetics and treatment of osteomyelitis. I. Preparation and drug release. J Biomed Mater Res A. 2013 May; 101(5):1416-26.
        View in: PubMed
      28. Uskokovic V, Desai TA. Phase composition control of calcium phosphate nanoparticles for tunable drug delivery kinetics and treatment of osteomyelitis. II. Antibacterial and osteoblastic response. J Biomed Mater Res A. 2013 May; 101(5):1427-36.
        View in: PubMed
      29. Bernards DA, Lance KD, Ciaccio NA, Desai TA. Nanostructured thin film polymer devices for constant-rate protein delivery. Nano Lett. 2012 Oct 10; 12(10):5355-61.
        View in: PubMed
      30. Chirra HD, Desai TA. Multi-reservoir bioadhesive microdevices for independent rate-controlled delivery of multiple drugs. Small. 2012 Dec 21; 8(24):3839-46.
        View in: PubMed
      31. Chirra HD, Desai TA. Emerging microtechnologies for the development of oral drug delivery devices. Adv Drug Deliv Rev. 2012 Nov; 64(14):1569-78.
        View in: PubMed
      32. Uskokovic V, Lee K, Lee PP, Fischer KE, Desai TA. Shape effect in the design of nanowire-coated microparticles as transepithelial drug delivery devices. ACS Nano. 2012 Sep 25; 6(9):7832-41.
        View in: PubMed
      33. Chavez MG, Yu W, Biehs B, Harada H, Snead ML, Lee JS, Desai TA, Klein OD. Characterization of dental epithelial stem cells from the mouse incisor with two-dimensional and three-dimensional platforms. Tissue Eng Part C Methods. 2013 Jan; 19(1):15-24.
        View in: PubMed
      34. Mendelsohn AD, Nyitray C, Sena M, Desai TA. Size-controlled insulin-secreting cell clusters. Acta Biomater. 2012 Dec; 8(12):4278-84.
        View in: PubMed
      35. Crawford C, Kennedy-Lydon T, Sprott C, Desai T, Sawbridge L, Munday J, Unwin RJ, Wildman SS, Peppiatt-Wildman CM. An intact kidney slice model to investigate vasa recta properties and function in situ. Nephron Physiol. 2012; 120(3):p17-31.
        View in: PubMed
      36. Horst OV, Chavez MG, Jheon AH, Desai T, Klein OD. Stem cell and biomaterials research in dental tissue engineering and regeneration. Dent Clin North Am. 2012 Jul; 56(3):495-520.
        View in: PubMed
      37. Tucker RM, Parcher BW, Jones EF, Desai TA. Single-injection HPLC method for rapid analysis of a combination drug delivery system. AAPS PharmSciTech. 2012 Jun; 13(2):605-10.
        View in: PubMed
      38. Curtis MW, Budyn E, Desai TA, Samarel AM, Russell B. Microdomain heterogeneity in 3D affects the mechanics of neonatal cardiac myocyte contraction. Biomech Model Mechanobiol. 2013 Jan; 12(1):95-109.
        View in: PubMed
      39. Armitage B, Desai T, Jiang S, Whitten D. Preface for the Bioinspired Assemblies and Interfaces Special Issue. Langmuir. 2012 Jan 31; 28(4):1943.
        View in: PubMed
      40. Minami SS, Sun B, Popat K, Kauppinen T, Pleiss M, Zhou Y, Ward ME, Floreancig P, Mucke L, Desai T, Gan L. Selective targeting of microglia by quantum dots. J Neuroinflammation. 2012; 9:22.
        View in: PubMed
      41. Muthusubramaniam L, Peng L, Zaitseva T, Paukshto M, Martin GR, Desai TA. Collagen fibril diameter and alignment promote the quiescent keratocyte phenotype. J Biomed Mater Res A. 2012 Mar; 100(3):613-21.
        View in: PubMed
      42. Uskokovic V, Lee PP, Walsh LA, Fischer KE, Desai TA. PEGylated silicon nanowire coated silica microparticles for drug delivery across intestinal epithelium. Biomaterials. 2012 Feb; 33(5):1663-72.
        View in: PubMed
      43. Roy S, Goldman K, Marchant R, Zydney A, Brown D, Fleischman A, Conlisk A, Desai T, Duffy S, Humes H, Fissell W. Implanted renal replacement for end-stage renal disease. Panminerva Med. 2011 Sep; 53(3):155-66.
        View in: PubMed
      44. Patel AA, Desai TA, Kumar S. Microtopographical assembly of cardiomyocytes. Integr Biol (Camb). 2011 Oct; 3(10):1011-9.
        View in: PubMed
      45. Ayala P, Desai TA. Integrin a3 blockade enhances microtopographical down-regulation of a-smooth muscle actin: role of microtopography in ECM regulation. Integr Biol (Camb). 2011 Jul; 3(7):733-41.
        View in: PubMed
      46. Van Hoof D, Mendelsohn AD, Seerke R, Desai TA, German MS. Differentiation of human embryonic stem cells into pancreatic endoderm in patterned size-controlled clusters. Stem Cell Res. 2011 May; 6(3):276-85.
        View in: PubMed
      47. Fischer KE, Nagaraj G, Hugh Daniels R, Li E, Cowles VE, Miller JL, Bunger MD, Desai TA. Hierarchical nanoengineered surfaces for enhanced cytoadhesion and drug delivery. Biomaterials. 2011 May; 32(13):3499-506.
        View in: PubMed
      48. Muthusubramaniam L, Lowe R, Fissell WH, Li L, Marchant RE, Desai TA, Roy S. Hemocompatibility of silicon-based substrates for biomedical implant applications. Ann Biomed Eng. 2011 Apr; 39(4):1296-305.
        View in: PubMed
      49. Fischer KE, Jayagopal A, Nagaraj G, Daniels RH, Li EM, Silvestrini MT, Desai TA. Nanoengineered surfaces enhance drug loading and adhesion. Nano Lett. 2011 Mar 9; 11(3):1076-81.
        View in: PubMed
      50. Desai T. In the spotlight: tissue engineering--translation for tissue engineering and regenerative medicine. IEEE Rev Biomed Eng. 2011; 4:24-5.
        View in: PubMed
      51. Curtis MW, Sharma S, Desai TA, Russell B. Hypertrophy, gene expression, and beating of neonatal cardiac myocytes are affected by microdomain heterogeneity in 3D. Biomed Microdevices. 2010 Dec; 12(6):1073-85.
        View in: PubMed
      52. Saldanha KJ, Doan RP, Ainslie KM, Desai TA, Majumdar S. Micrometer-sized iron oxide particle labeling of mesenchymal stem cells for magnetic resonance imaging-based monitoring of cartilage tissue engineering. Magn Reson Imaging. 2011 Jan; 29(1):40-9.
        View in: PubMed
      53. Ayala P, Lopez JI, Desai TA. Microtopographical cues in 3D attenuate fibrotic phenotype and extracellular matrix deposition: implications for tissue regeneration. Tissue Eng Part A. 2010 Aug; 16(8):2519-27.
        View in: PubMed
      54. Mendelsohn AD, Bernards DA, Lowe RD, Desai TA. Patterning of mono- and multilayered pancreatic beta-cell clusters. Langmuir. 2010 Jun 15; 26(12):9943-9.
        View in: PubMed
      55. Bernards DA, Desai TA. Nanotemplating of biodegradable polymer membranes for constant-rate drug delivery. Adv Mater. 2010 Jun 4; 22(21):2358-62.
        View in: PubMed
      56. Steedman MR, Tao SL, Klassen H, Desai TA. Enhanced differentiation of retinal progenitor cells using microfabricated topographical cues. Biomed Microdevices. 2010 Jun; 12(3):363-9.
        View in: PubMed
      57. Patel AA, Thakar RG, Chown M, Ayala P, Desai TA, Kumar S. Biophysical mechanisms of single-cell interactions with microtopographical cues. Biomed Microdevices. 2010 Apr; 12(2):287-96.
        View in: PubMed
      58. Collins JM, Ayala P, Desai TA, Russell B. Three-dimensional culture with stiff microstructures increases proliferation and slows osteogenic differentiation of human mesenchymal stem cells. Small. 2010 Feb 5; 6(3):355-60.
        View in: PubMed
      59. Peng L, Barczak AJ, Barbeau RA, Xiao Y, LaTempa TJ, Grimes CA, Desai TA. Whole genome expression analysis reveals differential effects of TiO2 nanotubes on vascular cells. Nano Lett. 2010 Jan; 10(1):143-8.
        View in: PubMed
      60. Bernards DA, Desai TA. Nanoscale porosity in polymer films: fabrication and therapeutic applications. Soft Matter. 2010 Jan 1; 6(8):1621-1631.
        View in: PubMed
      61. Mendelsohn A, Desai T. Inorganic nanoporous membranes for immunoisolated cell-based drug delivery. Adv Exp Med Biol. 2010; 670:104-25.
        View in: PubMed
      62. Desai TA. In the spotlight: tissue engineering. IEEE Rev Biomed Eng. 2010; 3:23-4.
        View in: PubMed
      63. Ainslie KM, Tao SL, Popat KC, Daniels H, Hardev V, Grimes CA, Desai TA. In vitro inflammatory response of nanostructured titania, silicon oxide, and polycaprolactone. J Biomed Mater Res A. 2009 Dec; 91(3):647-55.
        View in: PubMed
      64. Ainslie KM, Lowe RD, Beaudette TT, Petty L, Bachelder EM, Desai TA. Microfabricated devices for enhanced bioadhesive drug delivery: attachment to and small-molecule release through a cell monolayer under flow. Small. 2009 Dec; 5(24):2857-63.
        View in: PubMed
      65. Biehl JK, Yamanaka S, Desai TA, Boheler KR, Russell B. Proliferation of mouse embryonic stem cell progeny and the spontaneous contractile activity of cardiomyocytes are affected by microtopography. Dev Dyn. 2009 Aug; 238(8):1964-73.
        View in: PubMed
      66. Peng L, Mendelsohn AD, LaTempa TJ, Yoriya S, Grimes CA, Desai TA. Long-term small molecule and protein elution from TiO2 nanotubes. Nano Lett. 2009 May; 9(5):1932-6.
        View in: PubMed
      67. Fischer KE, Alemán BJ, Tao SL, Hugh Daniels R, Li EM, Bünger MD, Nagaraj G, Singh P, Zettl A, Desai TA. Biomimetic nanowire coatings for next generation adhesive drug delivery systems. Nano Lett. 2009 Feb; 9(2):716-20.
        View in: PubMed
      68. Desai TA. In the spotlight: tissue engineering--quantitative analysis of complex 3-D tissues. IEEE Rev Biomed Eng. 2009; 2:21-2.
        View in: PubMed
      69. Peng L, Eltgroth ML, LaTempa TJ, Grimes CA, Desai TA. The effect of TiO2 nanotubes on endothelial function and smooth muscle proliferation. Biomaterials. 2009 Mar; 30(7):1268-72.
        View in: PubMed
      70. Ainslie KM, Desai TA. Microfabricated implants for applications in therapeutic delivery, tissue engineering, and biosensing. Lab Chip. 2008 Nov; 8(11):1864-78.
        View in: PubMed
      71. Thakar RG, Chown MG, Patel A, Peng L, Kumar S, Desai TA. Contractility-dependent modulation of cell proliferation and adhesion by microscale topographical cues. Small. 2008 Sep; 4(9):1416-24.
        View in: PubMed
      72. Pattani VP, Li C, Desai TA, Vu TQ. Microcontact printing of quantum dot bioconjugate arrays for localized capture and detection of biomolecules. Biomed Microdevices. 2008 Jun; 10(3):367-74.
        View in: PubMed
      73. Redenti S, Tao S, Yang J, Gu P, Klassen H, Saigal S, Desai T, Young MJ. Retinal tissue engineering using mouse retinal progenitor cells and a novel biodegradable, thin-film poly(e-caprolactone) nanowire scaffold. J Ocul Biol Dis Infor. 2008 Mar; 1(1):19-29.
        View in: PubMed
      74. Ainslie KM, Kraning CM, Desai TA. Microfabrication of an asymmetric, multi-layered microdevice for controlled release of orally delivered therapeutics. Lab Chip. 2008 Jul; 8(7):1042-7.
        View in: PubMed
      75. Ainslie KM, Tao SL, Popat KC, Desai TA. In vitro immunogenicity of silicon-based micro- and nanostructured surfaces. ACS Nano. 2008 May; 2(5):1076-84.
        View in: PubMed
      76. Norman JJ, Collins JM, Sharma S, Russell B, Desai TA. Microstructures in 3D biological gels affect cell proliferation. Tissue Eng Part A. 2008 Mar; 14(3):379-90.
        View in: PubMed
      77. Nehilla BJ, Allen PG, Desai TA. Surfactant-free, drug-quantum-dot coloaded poly(lactide-co-glycolide) nanoparticles: towards multifunctional nanoparticles. ACS Nano. 2008 Mar; 2(3):538-44.
        View in: PubMed
      78. Tao SL, Popat KC, Norman JJ, Desai TA. Surface modification of SU-8 for enhanced biofunctionality and nonfouling properties. Langmuir. 2008 Mar 18; 24(6):2631-6.
        View in: PubMed
      79. Houtchens GR, Foster MD, Desai TA, Morgan EF, Wong JY. Combined effects of microtopography and cyclic strain on vascular smooth muscle cell orientation. J Biomech. 2008; 41(4):762-9.
        View in: PubMed
      80. Sarkar S, Isenberg BC, Hodis E, Leach JB, Desai TA, Wong JY. Fabrication of a layered microstructured polycaprolactone construct for 3-D tissue engineering. J Biomater Sci Polym Ed. 2008; 19(10):1347-62.
        View in: PubMed
      81. Desai TA. In the Spotlight: Tissue and Molecular Engineering. IEEE Rev Biomed Eng. 2008; 1:21-2.
        View in: PubMed
      82. Popat KC, Eltgroth M, LaTempa TJ, Grimes CA, Desai TA. Titania nanotubes: a novel platform for drug-eluting coatings for medical implants? Small. 2007 Nov; 3(11):1878-81.
        View in: PubMed
      83. Neeley WL, Redenti S, Klassen H, Tao S, Desai T, Young MJ, Langer R. A microfabricated scaffold for retinal progenitor cell grafting. Biomaterials. 2008 Feb; 29(4):418-26.
        View in: PubMed
      84. Popat KC, Eltgroth M, Latempa TJ, Grimes CA, Desai TA. Decreased Staphylococcus epidermis adhesion and increased osteoblast functionality on antibiotic-loaded titania nanotubes. Biomaterials. 2007 Nov; 28(32):4880-8.
        View in: PubMed
      85. Nehilla BJ, Bergkvist M, Popat KC, Desai TA. Purified and surfactant-free coenzyme Q10-loaded biodegradable nanoparticles. Int J Pharm. 2008 Feb 4; 348(1-2):107-14.
        View in: PubMed
      86. Tao SL, Desai TA. Aligned arrays of biodegradable poly(epsilon-caprolactone) nanowires and nanofibers by template synthesis. Nano Lett. 2007 Jun; 7(6):1463-8.
        View in: PubMed
      87. Tan W, Vinegoni C, Norman JJ, Desai TA, Boppart SA. Imaging cellular responses to mechanical stimuli within three-dimensional tissue constructs. Microsc Res Tech. 2007 Apr; 70(4):361-71.
        View in: PubMed
      88. Tao S, Young C, Redenti S, Zhang Y, Klassen H, Desai T, Young MJ. Survival, migration and differentiation of retinal progenitor cells transplanted on micro-machined poly(methyl methacrylate) scaffolds to the subretinal space. Lab Chip. 2007 Jun; 7(6):695-701.
        View in: PubMed
      89. Popat KC, Leoni L, Grimes CA, Desai TA. Influence of engineered titania nanotubular surfaces on bone cells. Biomaterials. 2007 Jul; 28(21):3188-97.
        View in: PubMed
      90. Popat KC, Chatvanichkul KI, Barnes GL, Latempa TJ, Grimes CA, Desai TA. Osteogenic differentiation of marrow stromal cells cultured on nanoporous alumina surfaces. J Biomed Mater Res A. 2007 Mar 15; 80(4):955-64.
        View in: PubMed
      91. La Flamme KE, Popat KC, Leoni L, Markiewicz E, La Tempa TJ, Roman BB, Grimes CA, Desai TA. Biocompatibility of nanoporous alumina membranes for immunoisolation. Biomaterials. 2007 Jun; 28(16):2638-45.
        View in: PubMed
      92. La Flamme KE, LaTempa TJ, Grimes CA, Desai TA. The effects of cell density and device arrangement on the behavior of macroencapsulated beta-cells. Cell Transplant. 2007; 16(8):765-74.
        View in: PubMed
      93. Tan W, Oldenburg AL, Norman JJ, Desai TA, Boppart SA. Optical coherence tomography of cell dynamics in three-dimensional tissue models. Opt Express. 2006 Aug 7; 14(16):7159-71.
        View in: PubMed
      94. Sarkar S, Lee GY, Wong JY, Desai TA. Development and characterization of a porous micro-patterned scaffold for vascular tissue engineering applications. Biomaterials. 2006 Sep; 27(27):4775-82.
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      95. Popat KC, Daniels RH, Dubrow RS, Hardev V, Desai TA. Nanostructured surfaces for bone biotemplating applications. J Orthop Res. 2006 Apr; 24(4):619-27.
        View in: PubMed
      96. Ohno S, Schmid T, Tanne Y, Kamiya T, Honda K, Ohno-Nakahara M, Swentko N, Desai TA, Tanne K, Knudson CB, Knudson W. Expression of superficial zone protein in mandibular condyle cartilage. Osteoarthritis Cartilage. 2006 Aug; 14(8):807-13.
        View in: PubMed
      97. Norman JJ, Desai TA. Methods for fabrication of nanoscale topography for tissue engineering scaffolds. Ann Biomed Eng. 2006 Jan; 34(1):89-101.
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      98. Lopez CA, Fleischman AJ, Roy S, Desai TA. Evaluation of silicon nanoporous membranes and ECM-based microenvironments on neurosecretory cells. Biomaterials. 2006 Jun; 27(16):3075-83.
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      99. Saltzman M, Desai T. Drug delivery in the BME curricula. Ann Biomed Eng. 2006 Feb; 34(2):270-5.
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      100. Nayak NR, Kuo CJ, Desai TA, Wiegand SJ, Lasley BL, Giudice LC, Brenner RM. Expression, localization and hormonal control of angiopoietin-1 in the rhesus macaque endometrium: potential role in spiral artery growth. Mol Hum Reprod. 2005 Nov; 11(11):791-9.
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      101. Tao SL, Popat K, Desai TA. Off-wafer fabrication and surface modification of asymmetric 3D SU-8 microparticles. Nat Protoc. 2006; 1(6):3153-8.
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      102. Gimi B, Leoni L, Oberholzer J, Braun M, Avila J, Wang Y, Desai T, Philipson LH, Magin RL, Roman BB. Functional MR microimaging of pancreatic beta-cell activation. Cell Transplant. 2006; 15(2):195-203.
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      103. Nehilla BJ, Vu TQ, Desai TA. Stoichiometry-dependent formation of quantum dot-antibody bioconjugates: a complementary atomic force microscopy and agarose gel electrophoresis study. J Phys Chem B. 2005 Nov 10; 109(44):20724-30.
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      104. Tao SL, Desai TA. Micromachined devices: the impact of controlled geometry from cell-targeting to bioavailability. J Control Release. 2005 Dec 5; 109(1-3):127-38.
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      105. La Flamme KE, Mor G, Gong D, La Tempa T, Fusaro VA, Grimes CA, Desai TA. Nanoporous alumina capsules for cellular macroencapsulation: transport and biocompatibility. Diabetes Technol Ther. 2005 Oct; 7(5):684-94.
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      106. Popat KC, Leary Swan EE, Desai TA. Modeling of RGDC film parameters using X-ray photoelectron spectroscopy. Langmuir. 2005 Aug 2; 21(16):7061-5.
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      107. Tao SL, Desai TA. Gastrointestinal patch systems for oral drug delivery. Drug Discov Today. 2005 Jul 1; 10(13):909-15.
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      108. Swan EE, Popat KC, Desai TA. Peptide-immobilized nanoporous alumina membranes for enhanced osteoblast adhesion. Biomaterials. 2005 May; 26(14):1969-76.
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      109. Vu TQ, Maddipati R, Blute TA, Nehilla BJ, Nusblat L, Desai TA. Peptide-conjugated quantum dots activate neuronal receptors and initiate downstream signaling of neurite growth. Nano Lett. 2005 Apr; 5(4):603-7.
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      110. Swan EE, Popat KC, Grimes CA, Desai TA. Fabrication and evaluation of nanoporous alumina membranes for osteoblast culture. J Biomed Mater Res A. 2005 Mar 1; 72(3):288-95.
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      111. Norman JJ, Desai TA. Control of cellular organization in three dimensions using a microfabricated polydimethylsiloxane-collagen composite tissue scaffold. Tissue Eng. 2005 Mar-Apr; 11(3-4):378-86.
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      112. Tan W, Desai TA. Microscale multilayer cocultures for biomimetic blood vessels. J Biomed Mater Res A. 2005 Feb 1; 72(2):146-60.
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      113. Sharma S, Desai TA. Nanostructured antifouling poly(ethylene glycol) films for silicon-based microsystems. J Nanosci Nanotechnol. 2005 Feb; 5(2):235-43.
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      114. Sharma S, Tan W, Desai TA. Improving the integrity of three-dimensional vascular patterns by poly(ethylene glycol) conjugation. Bioconjug Chem. 2005 Jan-Feb; 16(1):18-22.
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      115. Sarkar S, Dadhania M, Rourke P, Desai TA, Wong JY. Vascular tissue engineering: microtextured scaffold templates to control organization of vascular smooth muscle cells and extracellular matrix. Acta Biomater. 2005 Jan; 1(1):93-100.
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      116. Popat KC, Leary Swan EE, Mukhatyar V, Chatvanichkul KI, Mor GK, Grimes CA, Desai TA. Influence of nanoporous alumina membranes on long-term osteoblast response. Biomaterials. 2005 Aug; 26(22):4516-22.
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      117. Desai TA, West T, Cohen M, Boiarski T, Rampersaud A. Nanoporous microsystems for islet cell replacement. Adv Drug Deliv Rev. 2004 Sep 22; 56(11):1661-73.
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      118. Sharma S, Johnson RW, Desai TA. XPS and AFM analysis of antifouling PEG interfaces for microfabricated silicon biosensors. Biosens Bioelectron. 2004 Sep 15; 20(2):227-39.
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      119. Popat KC, Mor G, Grimes CA, Desai TA. Surface modification of nanoporous alumina surfaces with poly(ethylene glycol). Langmuir. 2004 Sep 14; 20(19):8035-41.
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      120. Nehilla BJ, Popat KC, Vu TQ, Chowdhury S, Standaert RF, Pepperberg DR, Desai TA. Neurotransmitter analog tethered to a silicon platform for neuro-BioMEMS applications. Biotechnol Bioeng. 2004 Sep 5; 87(5):669-74.
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      121. Cai Q, Zeng K, Ruan C, Desai TA, Grimes CA. A wireless, remote query glucose biosensor based on a pH-sensitive polymer. Anal Chem. 2004 Jul 15; 76(14):4038-43.
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      122. Popat KC, Desai TA. Poly(ethylene glycol) interfaces: an approach for enhanced performance of microfluidic systems. Biosens Bioelectron. 2004 Apr 15; 19(9):1037-44.
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      123. Tan W, Desai TA. Layer-by-layer microfluidics for biomimetic three-dimensional structures. Biomaterials. 2004 Mar-Apr; 25(7-8):1355-64.
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      124. Leoni L, Desai TA. Micromachined biocapsules for cell-based sensing and delivery. Adv Drug Deliv Rev. 2004 Feb 10; 56(2):211-29.
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      125. Sharma S, Johnson RW, Desai TA. Evaluation of the stability of nonfouling ultrathin poly(ethylene glycol) films for silicon-based microdevices. Langmuir. 2004 Jan 20; 20(2):348-56.
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      126. Tao SL, Lubeley MW, Desai TA. Synthesis of cytoadhesive poly(methylmethacrylate) for applications in targeted drug delivery. J Biomed Mater Res A. 2003 Nov 1; 67(2):369-75.
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      127. Attiah DG, Kopher RA, Desai TA. Characterization of PC12 cell proliferation and differentiation-stimulated by ECM adhesion proteins and neurotrophic factors. J Mater Sci Mater Med. 2003 Nov; 14(11):1005-9.
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      128. Motlagh D, Hartman TJ, Desai TA, Russell B. Microfabricated grooves recapitulate neonatal myocyte connexin43 and N-cadherin expression and localization. J Biomed Mater Res A. 2003 Oct 1; 67(1):148-57.
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      129. Saifuddin U, Vu TQ, Rezac M, Qian H, Pepperberg DR, Desai TA. Assembly and characterization of biofunctional neurotransmitter-immobilized surfaces for interaction with postsynaptic membrane receptors. J Biomed Mater Res A. 2003 Jul 1; 66(1):184-91.
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      130. Motlagh D, Senyo SE, Desai TA, Russell B. Microtextured substrata alter gene expression, protein localization and the shape of cardiac myocytes. Biomaterials. 2003 Jun; 24(14):2463-76.
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      131. Boateng SY, Hartman TJ, Ahluwalia N, Vidula H, Desai TA, Russell B. Inhibition of fibroblast proliferation in cardiac myocyte cultures by surface microtopography. Am J Physiol Cell Physiol. 2003 Jul; 285(1):C171-82.
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      132. Tan W, Desai TA. Microfluidic patterning of cells in extracellular matrix biopolymers: effects of channel size, cell type, and matrix composition on pattern integrity. Tissue Eng. 2003 Apr; 9(2):255-67.
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      133. Tao SL, Lubeley MW, Desai TA. Bioadhesive poly(methyl methacrylate) microdevices for controlled drug delivery. J Control Release. 2003 Mar 7; 88(2):215-28.
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      134. Tao SL, Desai TA. Microfabricated drug delivery systems: from particles to pores. Adv Drug Deliv Rev. 2003 Feb 24; 55(3):315-28.
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      135. Davis DH, Giannoulis CS, Johnson RW, Desai TA. Immobilization of RGD to < 1 1 1 > silicon surfaces for enhanced cell adhesion and proliferation. Biomaterials. 2002 Oct; 23(19):4019-27.
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      136. Desai TA. Microfabrication technology for pancreatic cell encapsulation. Expert Opin Biol Ther. 2002 Aug; 2(6):633-46.
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      137. Ahmed A, Bonner C, Desai TA. Bioadhesive microdevices with multiple reservoirs: a new platform for oral drug delivery. J Control Release. 2002 Jun 17; 81(3):291-306.
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      138. Weis RP, Montchamp JL, Coffer JL, Attiah DG, Desai TA. Calcified nanostructured silicon wafer surfaces for biosensing: effects of surface modification on bioactivity. Dis Markers. 2002; 18(4):159-65.
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      139. Giannoulis CS, Desai TA. Characterization of proteins and fibroblasts on thin inorganic films. J Mater Sci Mater Med. 2002 Jan; 13(1):75-80.
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      140. Leoni L, Desai TA. Nanoporous biocapsules for the encapsulation of insulinoma cells: biotransport and biocompatibility considerations. IEEE Trans Biomed Eng. 2001 Nov; 48(11):1335-41.
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      141. Tan W, Krishnaraj R, Desai TA. Evaluation of nanostructured composite collagen--chitosan matrices for tissue engineering. Tissue Eng. 2001 Apr; 7(2):203-10.
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      142. Snyder JD, Desai TA. Microscale three-dimensional polymeric platforms for in vitro cell culture systems. J Biomater Sci Polym Ed. 2001; 12(8):921-32.
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      143. Desai TA. Micro- and nanoscale structures for tissue engineering constructs. Med Eng Phys. 2000 Nov; 22(9):595-606.
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      144. Desai TA, Hansford DJ, Ferrari M. Micromachined interfaces: new approaches in cell immunoisolation and biomolecular separation. Biomol Eng. 2000 Oct; 17(1):23-36.
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      145. Desai TA, Hansford DJ, Leoni L, Essenpreis M, Ferrari M. Nanoporous anti-fouling silicon membranes for biosensor applications. Biosens Bioelectron. 2000; 15(9-10):453-62.
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      146. Deutsch J, Motlagh D, Russell B, Desai TA. Fabrication of microtextured membranes for cardiac myocyte attachment and orientation. J Biomed Mater Res. 2000; 53(3):267-75.
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      147. Desai TA, Chu WH, Rasi G, Sinibaldi-Vallebona P, Guarino E, Ferrari M. Microfabricated biocapsules provide short-term immunoisolation of insulinoma xenografts. Biomed Microdevices. 1999; 1(2):131-8.
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      148. Zhang M, Desai T, Ferrari M. Proteins and cells on PEG immobilized silicon surfaces. Biomaterials. 1998 May; 19(10):953-60.
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      149. Desai TA, Chu WH, Tu JK, Beattie GM, Hayek A, Ferrari M. Microfabricated immunoisolating biocapsules. Biotechnol Bioeng. 1998 Jan 5; 57(1):118-20.
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      150. Wang W, Wu W, Desai T, Ward DC, Kaufman SJ. Localization of the alpha 7 integrin gene (ITGA7) on human chromosome 12q13: clustering of integrin and Hox genes implies parallel evolution of these gene families. Genomics. 1995 Apr 10; 26(3):568-70.
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