Kathy Giacomini, PhD
|School||UCSF School of Pharmacy|
|Address||1550 4th Street, Bldg 19B|
San Francisco CA 94158
|Title||Chair, Bioengineering and Therapeutic Sciences|
|Swedish Academy of Pharmaceutical Scientists||2011||Scheele Award|
|Therapeutic Frontiers Lecture Award||2010||Therapeutic Frontiers Lecture Award|
|Postdoctoral Scholars Association, University of California, San Francisco||2009||Outstanding Mentor Award|
|American Society for Clinical Pharmacology and Therapeutics||2009||Rawls-Palmer Progress in Medicine Award|
|Japan Society for the Promotion of Science||2008||Invitation Fellowship Program for Research in Japan|
|Academy of Pharmaceutical Sciences and Technology, Japan||2007||International Woman Scientist Award|
|Pharmaceutical Sciences World Congress||2007||Research Achievement Award|
|Institute of Medicine of the National Academy of Sciences||2006||Elected Member|
|American Association of Pharmaceutical Scientists||2006||Distinguished Scientist Award in Drug Metabolism|
|American Association of Colleges of Pharmacy||2005||Paul Dawson Biotechnology Award|
|State University of New York at Buffalo||2002||Distinguished Gerhard Levy Lectureship|
|U.S. Food and Drug Administration||2002||Distinguished Bill Abram's Lectureship|
|University of California, San Francisco||2002||Honored Celebrating Women Faculty|
|University of Kentucky||2000||Guttman Lecturer|
|International Pharmaceutical Federation (FIP)||1999||Scientist of the Year|
|University of California, San Francisco||1999||Recognition Award for Distinguished Achievement of a Filipino at UCSF|
|University of California, San Francisco||1997||Chancellor's Award for the Advancement of Women|
|University of California, San Francisco||1994||Martin Luther King, Jr. Award for the Advancement of Minorities|
|National Institutes of Health||1992||Fogarty International Fellowship|
|American Society for Clinical Pharmacology and Therapeutics||1990||Leon Goldberg Young Investigator Award|
|University of California, San Francisco, Academic Senate||1985||Distinguished Teaching Award|
|American Association of University Women||1984||UCSF Nominee for Recognition Award for Young Scholar|
|School of Pharmacy, University of California, San Francisco||1983||Long Foundation Award for Excellence in Teaching|
Kathy Giacomini's research group focuses on membrane transporters, which are of great pharmacological importance as they play a major role in drug disposition and response. Major questions addressed in the laboratory include: What is the in vivo role of membrane transporters in drug disposition and response? How does genetic variation in membrane transporters affect clinical drug response? What is the endogenous role of membrane transporters? What are the structural determinants of specificity?
As PI of the major project funded by NIH, Pharmacogenetics of Membrane Transporters, Giacomini is leading an effort to understand the implications of genetic variation in over 100 membrane transporters on clinical drug response. Studies of the project, ranging from discovery to clinical studies, have demonstrated that common variants of membrane transporters contribute to variation in drug response. Ultimately, the information obtained from these studies may be used in personalizing drug therapy and may even be used to design drugs to better treat subsets of patients who do not respond to standard treatments.
Research in the laboratory focuses on the anti-diabetic drug, metformin, and on anti-cancer drugs. By mediating influx of efflux in tumor cells, many membrane transporters play critical roles in sensitivity and resistance to anti-cancer drugs. Giacomini and her colleagues seek to determine whether genetic variation in transporters contributes to variation in sensitivity and resistance to anti-cancer drugs. She is particularly interested in modifying anti-cancer drugs to target transporters in tumors thereby enhancing their uptake and efficacy.
Pharmaceutical sciences, pharmacogenomics, pharmacogenetics, membrane transporters, metformin, regulatory sciences, bioengineering, therapeutics.
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