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Kathy Giacomini, PhD

TitleProfessor
SchoolUCSF School of Pharmacy
DepartmentBioengineering
Address1550 4th Street, Bldg 19B
San Francisco CA 94158
Phone415-476-1936
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    Other Positions
    TitleCo-Director UCSF-Stanford Center of Excellence in Regulatory Sciences and Innovation


    Collapse Biography 
    Collapse Awards and Honors
    Swedish Academy of Pharmaceutical Scientists2011Scheele Award
    Therapeutic Frontiers Lecture Award2010Therapeutic Frontiers Lecture Award
    Postdoctoral Scholars Association, University of California, San Francisco2009Outstanding Mentor Award
    American Society for Clinical Pharmacology and Therapeutics2009Rawls-Palmer Progress in Medicine Award
    Japan Society for the Promotion of Science2008Invitation Fellowship Program for Research in Japan
    Academy of Pharmaceutical Sciences and Technology, Japan2007International Woman Scientist Award
    Pharmaceutical Sciences World Congress2007Research Achievement Award
    Institute of Medicine of the National Academy of Sciences2006Elected Member
    American Association of Pharmaceutical Scientists2006Distinguished Scientist Award in Drug Metabolism
    American Association of Colleges of Pharmacy2005Paul Dawson Biotechnology Award
    State University of New York at Buffalo2002Distinguished Gerhard Levy Lectureship
    U.S. Food and Drug Administration2002Distinguished Bill Abram's Lectureship
    University of California, San Francisco2002Honored Celebrating Women Faculty
    University of Kentucky2000Guttman Lecturer
    International Pharmaceutical Federation (FIP)1999Scientist of the Year
    University of California, San Francisco1999Recognition Award for Distinguished Achievement of a Filipino at UCSF
    University of California, San Francisco1997Chancellor's Award for the Advancement of Women
    University of California, San Francisco1994Martin Luther King, Jr. Award for the Advancement of Minorities
    National Institutes of Health1992Fogarty International Fellowship
    American Society for Clinical Pharmacology and Therapeutics1990Leon Goldberg Young Investigator Award
    University of California, San Francisco, Academic Senate1985Distinguished Teaching Award
    American Association of University Women1984UCSF Nominee for Recognition Award for Young Scholar
    School of Pharmacy, University of California, San Francisco1983Long Foundation Award for Excellence in Teaching

    Collapse Overview 
    Collapse Overview
    The Giacomini research group focuses on expanding our understanding of membrane transporters. Membrane transporters are of great pharmacological importance, as they play a major role in drug efficacy by regulating drug disposition and distribution. Major questions addressed in the laboratory include: What is the in vivo role of membrane transporters in drug disposition and response? How does genetic variation in membrane transporters affect clinical drug response? What is the endogenous role of membrane transporters? And, what are the structural determinants of specificity?

    As PI of the NIH-funded Pharmacogenomics of Membrane Transporters project, Dr. Kathy Giacomini is leading an effort to determine the clinical implications of specific genetic variants in over 100 membrane transporters. Project ventures, ranging from basic discovery to clinical studies, have demonstrated that common variants of membrane transporters contribute to differences in drug response in ethnically diverse populations. Ultimately, these studies will increase our knowledge of the genetic basis underlying drug response, and will contribute to advancing the era of personalized medicine. Furthermore, our studies will elucidate the genetic mechanisms of decreased drug response and, ultimately, contribute to improving drug design for safe and effective treatments of subgroups of patients who do not respond to standard treatments.

    Research in the laboratory focuses on drugs used in the treatment of diseases associated with metabolic syndrome. We are particularly interested in two key therapeutic agents, allopurinol, first-line medical therapy for gout and high uric acid levels, and the anti-diabetic drug, metformin, one of the world’s most widely prescribed drugs. In particular, our research focuses on discovering functional genetic variants that underlie variation in response to these drugs in large ethnically diverse patient populations. As a co-leader of the international MetGen consortium with over 10,000 patients from Europe and the U.S. on metformin, Giacomini and her collaborators are seeking to discover genetic factors that contribute to poor response to metformin. Importantly, her group is interested in understanding the molecular mechanisms responsible for metformin’s pharmacologic action. For allopurinol, we have discovered that genetic variants in membrane transporters contribute to variation in response to allopurinol. We are now seeking to understand the mechanisms through which the variants act on allopurinol response.

    Finally, Kathy Giacomini and her collaborator, Russ Altman of Stanford University are the Co-PIs of the UCSF–Stanford Center of Excellence in Regulatory Sciences and Innovation (CERSI) funded by the Food and Drug Administration (FDA). Established in 2014, the UCSF-Stanford CERSI aims to advance the field of regulatory sciences and improve the development and evaluation of diagnostics, therapeutics and medical devices. The UCSF-Stanford CERSI is the first FDA funded CERSI on the west coast and seeks to address key challenges related to education and research that will advance the discovery and development of medical products.


    Collapse Research 
    Collapse Research Activities and Funding
    UCSF-Stanford Center of Excellence in Regulatory Science
    NIH U01FD005978Sep 15, 2016 - Aug 31, 2021
    Role: Principal Investigator
    Discovery of Pharmacogenomic Biomarkers for Metformin Response
    NIH R01GM117163Sep 25, 2015 - Aug 31, 2019
    Role: Principal Investigator
    PGRN Administrative Coordination Hub, ACH (PGRN)
    NIH/NIGMS U24GM115370Jul 15, 2015 - Jun 30, 2020
    Role: Principal Investigator
    Role of ABCG2 in the disposition and anti-hyperuricemic effects of allopurinol
    NIH R01DK103729Sep 20, 2014 - Jul 31, 2018
    Role: Principal Investigator
    UCSF-Stanford Center of Excellence in Regulatory Science and Innovation
    NIH U01FD004979Apr 15, 2014 - Mar 31, 2017
    Role: Principal Investigator
    Center for Structure of Membrane Proteins
    NIH/NIGMS U54GM094625Sep 30, 2010 - Jun 30, 2015
    Role: Co-Investigator
    A Comprehensive Platform for Transporter Mediated Drug-Drug Interaction Studies
    NIH R44GM086970Feb 1, 2009 - Sep 30, 2013
    Role: Principal Investigator
    Pharmacogenomics of Membrane Transporters
    NIH U19GM061390Apr 1, 2000 - Jun 30, 2015
    Role: Principal Investigator
    Pharmacogenetics of Membrane Transporters
    NIH U01GM061390Apr 1, 2000 - Jul 14, 2010
    Role: Principal Investigator
    MOLECULAR BASIS OF DRUG TRANSPORT IN THE INTESTINE
    NIH/NIGMS R01GM057656Aug 1, 1997 - Jul 31, 2001
    Role: Principal Investigator
    MOLECULAR MECHANISMS OF DRUG TRANSPORT
    NIH F06TW001776Jan 1, 1992
    Role: Principal Investigator
    CELLULAR MECHANISMS OF DRUG TRANSPORT IN CHOROID PLEXUS
    NIH R01GM042230Jan 1, 1991 - Dec 31, 2003
    Role: Principal Investigator
    Cellular Mechanisms of Drug Elimination
    NIH R01GM036780Apr 4, 1986 - May 31, 2012
    Role: Principal Investigator
    STEREOSELECTIVE PHARMACOKINETICS OF DRUGS IN THE KIDNEY
    NIH R01GM031254Mar 1, 1983 - Jun 30, 1989
    Role: Principal Investigator
    PHARMACOKINETICS/PHARMACODYNAMICS
    NIH/NIGMS P50GM026691Aug 1, 1979 - Jul 31, 1998
    Role: Co-Investigator
    Resource for Biocomputing, Visualization, and Informatics
    NIH/NCRR P41RR001081Jun 1, 1976 - Sep 14, 2012
    Role: Co-Investigator
    General Clinical Research Center
    NIH/NCRR M01RR000079Dec 1, 1974 - Mar 31, 2009
    Role: Co-Investigator
    General Clinical Research Center
    NIH/NCRR M01RR000083Oct 1, 1974 - Nov 30, 2007
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse In The News
    Collapse Clinical Trials
    Collapse Global Health

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Irwin JJ, Pottel J, Zou L, Wen H, Zuk S, Zhang X, Sterling T, Shoichet BK, Lionberger R, Giacomini K, et al. A Molecular Basis for Innovation in Drug Excipients. Clin Pharmacol Ther. 2016 Aug 24. PMID: 27557422.
      View in: PubMed
    2. Hsueh CH, Yoshida K, Zhao P, Meyer TW, Zhang L, Huang SM, Giacomini K, et al. Identification and Quantitative Assessment of Uremic Solutes as Inhibitors of Renal Organic Anion Transporters, OAT1 and OAT3. Mol Pharm. 2016 Aug 9. PMID: 27467266.
      View in: PubMed
    3. Zhou K, Yee SW, Seiser EL, van Leeuwen N, Tavendale R, Bennett AJ, Groves CJ, Coleman RL, van der Heijden AA, Beulens JW, de Keyser CE, Zaharenko L, Rotroff DM, Out M, Jablonski KA, Chen L, Javorský M, Židzik J, Levin AM, Williams LK, Dujic T, Semiz S, Kubo M, Chien HC, Maeda S, Witte JS, Wu L, Tkác I, Kooy A, van Schaik RH, Stehouwer CD, Logie L, Sutherland C, Klovins J, Pirags V, Hofman A, Stricker BH, Motsinger-Reif AA, Wagner MJ, Innocenti F, Hart LM, Holman RR, McCarthy MI, Hedderson MM, Palmer CN, Florez JC, Giacomini K, Pearson ER, et al. Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin. Nat Genet. 2016 Aug 8. PMID: 27500523.
      View in: PubMed
    4. Yee SW, Giacomini MM, Hsueh CH, Weitz D, Liang X, Goswami S, Kinchen JM, Coelho A, Zur AA, Mertsch K, Brian W, Kroetz DL, Giacomini K, et al. Metabolomic and Genome-wide Association Studies Reveal Potential Endogenous Biomarkers for OATP1B1. Clin Pharmacol Ther. 2016 Jul 22. PMID: 27447836.
      View in: PubMed
    5. Goswami S, Yee SW, Xu F, Sridhar SB, Mosley JJ, Takahashi A, Kubo M, Maeda S, Davis RL, Roden DM, Hedderson MM, Giacomini K, Savic RM, et al. A Longitudinal HbA1c Model Elucidates Genes Linked to Disease Progression on Metformin. Clin Pharmacol Ther. 2016 Jul 14. PMID: 27415606.
      View in: PubMed
    6. Rotroff DM, Oki NO, Liang X, Yee SW, Stocker SL, Corum DG, Meisner M, Fiehn O, Motsinger-Reif AA, Giacomini K, Kaddurah-Daouk R. Pharmacometabolomic Assessment of Metformin in Non-diabetic, African Americans. Front Pharmacol. 2016; 7:135. PMID: 27378919.
      View in: PubMed
    7. Yee SW, Momozawa Y, Kamatani Y, Tyndale RF, Weinshilboum RM, Ratain MJ, Giacomini K, Kubo M, et al. Genomewide Association Studies in Pharmacogenomics: Meeting Report of the NIH Pharmacogenomics Research Network-RIKEN (PGRN-RIKEN) Collaboration. Clin Pharmacol Ther. 2016 Jun 3. PMID: 27256705.
      View in: PubMed
    8. Hibma JE, Zur AA, Castro RA, Wittwer MB, Keizer RJ, Yee SW, Goswami S, Stocker SL, Zhang X, Huang Y, Brett CM, Savic RM, Giacomini K. The Effect of Famotidine, a MATE1-Selective Inhibitor, on the Pharmacokinetics and Pharmacodynamics of Metformin. Clin Pharmacokinet. 2016 Jun; 55(6):711-21. PMID: 26597253.
      View in: PubMed
    9. Altman RB, Prabhu S, Sidow A, Zook JM, Goldfeder R, Litwack D, Ashley E, Asimenos G, Bustamante CD, Donigan K, Giacomini K, Johansen E, Khuri N, Lee E, Liang XS, Salit M, Serang O, Tezak Z, Wall DP, Mansfield E, Kass-Hout T. A research roadmap for next-generation sequencing informatics. Sci Transl Med. 2016 Apr 20; 8(335):335ps10. PMID: 27099173.
      View in: PubMed
    10. Augustyn E, Finke K, Zur AA, Hansen L, Heeren N, Chien HC, Lin L, Giacomini K, Colas C, Schlessinger A, Thomas AA. LAT-1 activity of meta-substituted phenylalanine and tyrosine analogs. Bioorg Med Chem Lett. 2016 Jun 1; 26(11):2616-21. PMID: 27106710.
      View in: PubMed
    11. Morrissey KM, Stocker SL, Chen EC, Castro RA, Brett CM, Giacomini K. The Effect of Nizatidine, a MATE2K Selective Inhibitor, on the Pharmacokinetics and Pharmacodynamics of Metformin in Healthy Volunteers. Clin Pharmacokinet. 2016 Apr; 55(4):495-506. PMID: 26507723.
      View in: PubMed
    12. Chhibber A, French CE, Yee SW, Gamazon ER, Theusch E, Qin X, Webb A, Papp AC, Wang A, Simmons CQ, Konkashbaev A, Chaudhry AS, Mitchel K, Stryke D, Ferrin TE, Weiss ST, Kroetz DL, Sadee W, Nickerson DA, Krauss RM, George AL, Schuetz EG, Medina MW, Cox NJ, Scherer SE, Giacomini K, Brenner SE. Transcriptomic variation of pharmacogenes in multiple human tissues and lymphoblastoid cell lines. Pharmacogenomics J. 2016 Feb 9. PMID: 26856248.
      View in: PubMed
    13. Chien HC, Zur AA, Maurer TS, Yee SW, Tolsma J, Jasper P, Scott DO, Giacomini KM. Rapid Method To Determine Intracellular Drug Concentrations in Cellular Uptake Assays: Application to Metformin in Organic Cation Transporter 1-Transfected Human Embryonic Kidney 293 Cells. Drug Metab Dispos. 2016 Mar; 44(3):356-64. PMID: 26700958.
      View in: PubMed
    14. Altman RB, Khuri N, Salit M, Giacomini K. Unmet needs: Research helps regulators do their jobs. Sci Transl Med. 2015 Nov 25; 7(315):315ps22. PMID: 26606966.
      View in: PubMed
    15. Liang X, Chien HC, Yee SW, Giacomini MM, Chen EC, Piao M, Hao J, Twelves J, Lepist EI, Ray AS, Giacomini K. Metformin Is a Substrate and Inhibitor of the Human Thiamine Transporter, THTR-2 (SLC19A3). Mol Pharm. 2015 Dec 7; 12(12):4301-10. PMID: 26528626.
      View in: PubMed
    16. Temple W, Mendelsohn L, Kim GE, Nekritz E, Gustafson WC, Lin L, Giacomini K, Naranjo A, Van Ryn C, Yanik GA, Kreissman SG, Hogarty M, Matthay KK, DuBois SG. Vesicular monoamine transporter protein expression correlates with clinical features, tumor biology, and MIBG avidity in neuroblastoma: a report from the Children's Oncology Group. Eur J Nucl Med Mol Imaging. 2016 Mar; 43(3):474-81. PMID: 26338179.
      View in: PubMed
    17. Yee SW, Lin L, Merski M, Keiser MJ, Gupta A, Zhang Y, Chien HC, Shoichet BK, Giacomini K. Prediction and validation of enzyme and transporter off-targets for metformin. J Pharmacokinet Pharmacodyn. 2015 Oct; 42(5):463-75. PMID: 26335661; PMCID: PMC4656030.
    18. Lin L, Yee SW, Kim RB, Giacomini KM. SLC transporters as therapeutic targets: emerging opportunities. Nat Rev Drug Discov. 2015 Aug; 14(8):543-60. PMID: 26111766.
      View in: PubMed
    19. Chen EC, Liang X, Yee SW, Geier EG, Stocker SL, Chen L, Giacomini K. Targeted disruption of organic cation transporter 3 attenuates the pharmacologic response to metformin. Mol Pharmacol. 2015 Jul; 88(1):75-83. PMID: 25920679; PMCID: PMC4468641 [Available on 07/01/16].
    20. Wen CC, Yee SW, Liang X, Hoffmann TJ, Kvale MN, Banda Y, Jorgenson E, Schaefer C, Risch N, Giacomini K. Genome-wide association study identifies ABCG2 (BCRP) as an allopurinol transporter and a determinant of drug response. Clin Pharmacol Ther. 2015 May; 97(5):518-25. PMID: 25676789; PMCID: PMC4479153.
    21. DuBois SG, Groshen S, Park JR, Haas-Kogan DA, Yang X, Geier E, Chen E, Giacomini K, Weiss B, Cohn SL, Granger MM, Yanik GA, Hawkins R, Courtier J, Jackson H, Goodarzian F, Shimada H, Czarnecki S, Tsao-Wei D, Villablanca JG, Marachelian A, Matthay KK. Phase I Study of Vorinostat as a Radiation Sensitizer with 131I-Metaiodobenzylguanidine (131I-MIBG) for Patients with Relapsed or Refractory Neuroblastoma. Clin Cancer Res. 2015 Jun 15; 21(12):2715-21. PMID: 25695691; PMCID: PMC4470833 [Available on 06/15/16].
    22. Dahlin A, Wittwer M, de la Cruz M, Woo JM, Bam R, Scharen-Guivel V, Flaherty J, Ray AS, Cihlar T, Gupta SK, Giacomini KM. A pharmacogenetic candidate gene study of tenofovir-associated Fanconi syndrome. Pharmacogenet Genomics. 2015 Feb; 25(2):82-92. PMID: 25485598; PMCID: PMC4331349 [Available on 02/01/16].
    23. Chen L, Yee SW, Giacomini K. OCT1 in hepatic steatosis and thiamine disposition. Cell Cycle. 2015; 14(3):283-4. PMID: 25590948; PMCID: PMC4353231 [Available on 02/01/16].
    24. Smith RP, Eckalbar WL, Morrissey KM, Luizon MR, Hoffmann TJ, Sun X, Jones SL, Force Aldred S, Ramamoorthy A, Desta Z, Liu Y, Skaar TC, Trinklein ND, Giacomini KM, Ahituv N. Genome-wide discovery of drug-dependent human liver regulatory elements. PLoS Genet. 2014 Oct; 10(10):e1004648. PMID: 25275310; PMCID: PMC4183418.
    25. Pawlyk AC, Giacomini K, McKeon C, Shuldiner AR, Florez JC. Metformin pharmacogenomics: current status and future directions. Diabetes. 2014 Aug; 63(8):2590-9. PMID: 25060887; PMCID: PMC4113063.
    26. Chen L, Shu Y, Liang X, Chen EC, Yee SW, Zur AA, Li S, Xu L, Keshari KR, Lin MJ, Chien HC, Zhang Y, Morrissey KM, Liu J, Ostrem J, Younger NS, Kurhanewicz J, Shokat KM, Ashrafi K, Giacomini K. OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin. Proc Natl Acad Sci U S A. 2014 Jul 8; 111(27):9983-8. PMID: 24961373; PMCID: PMC4103324.
    27. Goswami S, Gong L, Giacomini K, Altman RB, Klein TE. PharmGKB summary: very important pharmacogene information for SLC22A1. Pharmacogenet Genomics. 2014 Jun; 24(6):324-8. PMID: 24681965; PMCID: PMC4035531.
    28. Goswami S, Yee SW, Stocker S, Mosley JD, Kubo M, Castro R, Mefford JA, Wen C, Liang X, Witte J, Brett C, Maeda S, Simpson MD, Hedderson MM, Davis RL, Roden DM, Giacomini K, Savic RM. Genetic variants in transcription factors are associated with the pharmacokinetics and pharmacodynamics of metformin. Clin Pharmacol Ther. 2014 Sep; 96(3):370-9. PMID: 24853734; PMCID: PMC4171106.
    29. Clancy JP, Johnson SG, Yee SW, McDonagh EM, Caudle KE, Klein TE, Cannavo M, Giacomini K. Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for ivacaftor therapy in the context of CFTR genotype. Clin Pharmacol Ther. 2014 Jun; 95(6):592-7. PMID: 24598717; PMCID: PMC4026598.
    30. Hsu V, de L T Vieira M, Zhao P, Zhang L, Zheng JH, Nordmark A, Berglund EG, Giacomini K, Huang SM. Towards quantitation of the effects of renal impairment and probenecid inhibition on kidney uptake and efflux transporters, using physiologically based pharmacokinetic modelling and simulations. Clin Pharmacokinet. 2014 Mar; 53(3):283-93. PMID: 24214317; PMCID: PMC3927056.
    31. Geier EG, Chen EC, Webb A, Papp AC, Yee SW, Sadee W, Giacomini K. Profiling solute carrier transporters in the human blood-brain barrier. Clin Pharmacol Ther. 2013 Dec; 94(6):636-9. PMID: 24013810; PMCID: PMC3906042.
    32. Drake KA, Torgerson DG, Gignoux CR, Galanter JM, Roth LA, Huntsman S, Eng C, Oh SS, Yee SW, Lin L, Bustamante CD, Moreno-Estrada A, Sandoval K, Davis A, Borrell LN, Farber HJ, Kumar R, Avila PC, Brigino-Buenaventura E, Chapela R, Ford JG, Lenoir MA, Lurmann F, Meade K, Serebrisky D, Thyne S, Rodríguez-Cintrón W, Sen S, Rodríguez-Santana JR, Hernandez RD, Giacomini KM, Burchard EG. A genome-wide association study of bronchodilator response in Latinos implicates rare variants. J Allergy Clin Immunol. 2014 Feb; 133(2):370-8. PMID: 23992748; PMCID: PMC3938989.
    33. Schlessinger A, Yee SW, Sali A, Giacomini K. SLC classification: an update. Clin Pharmacol Ther. 2013 Jul; 94(1):19-23. PMID: 23778706; PMCID: PMC4068830.
    34. Giacomini K, Huang SM. Transporters in drug development and clinical pharmacology. Clin Pharmacol Ther. 2013 Jul; 94(1):3-9. PMID: 23778703.
      View in: PubMed
    35. Giacomini KM, Balimane PV, Cho SK, Eadon M, Edeki T, Hillgren KM, Huang SM, Sugiyama Y, Weitz D, Wen Y, Xia CQ, Yee SW, Zimdahl H, Niemi M. International Transporter Consortium commentary on clinically important transporter polymorphisms. Clin Pharmacol Ther. 2013 Jul; 94(1):23-6. PMID: 23778707.
      View in: PubMed
    36. Mushiroda T, Giacomini K, Kubo M. Special Section on Pharmacogenomics: recent advances and future directions. J Hum Genet. 2013 Jun; 58(6):305. PMID: 23797326.
      View in: PubMed
    37. Yee SW, Mefford JA, Singh N, Percival ME, Stecula A, Yang K, Witte JS, Takahashi A, Kubo M, Matsuda K, Giacomini K, Andreadis C. Impact of polymorphisms in drug pathway genes on disease-free survival in adults with acute myeloid leukemia. J Hum Genet. 2013 Jun; 58(6):353-61. PMID: 23677058; PMCID: PMC4068832.
    38. Yee SW, Nguyen AN, Brown C, Savic RM, Zhang Y, Castro RA, Cropp CD, Choi JH, Singh D, Tahara H, Stocker SL, Huang Y, Brett CM, Giacomini K. Reduced renal clearance of cefotaxime in asians with a low-frequency polymorphism of OAT3 (SLC22A8). J Pharm Sci. 2013 Sep; 102(9):3451-7. PMID: 23649425; PMCID: PMC4151246.
    39. Hillgren KM, Keppler D, Zur AA, Giacomini K, Stieger B, Cass CE, Zhang L. Emerging transporters of clinical importance: an update from the International Transporter Consortium. Clin Pharmacol Ther. 2013 Jul; 94(1):52-63. PMID: 23588305.
      View in: PubMed
    40. Geier EG, Schlessinger A, Fan H, Gable JE, Irwin JJ, Sali A, Giacomini K. Structure-based ligand discovery for the Large-neutral Amino Acid Transporter 1, LAT-1. Proc Natl Acad Sci U S A. 2013 Apr 2; 110(14):5480-5. PMID: 23509259; PMCID: PMC3619328.
    41. Dahlin A, Geier E, Stocker SL, Cropp CD, Grigorenko E, Bloomer M, Siegenthaler J, Xu L, Basile AS, Tang-Liu DD, Giacomini K. Gene expression profiling of transporters in the solute carrier and ATP-binding cassette superfamilies in human eye substructures. Mol Pharm. 2013 Feb 4; 10(2):650-63. PMID: 23268600; PMCID: PMC4032224.
    42. Wittwer MB, Zur AA, Khuri N, Kido Y, Kosaka A, Zhang X, Morrissey KM, Sali A, Huang Y, Giacomini K. Discovery of potent, selective multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) inhibitors through prescription drug profiling and computational modeling. J Med Chem. 2013 Feb 14; 56(3):781-95. PMID: 23241029; PMCID: PMC4068829.
    43. Schlessinger A, Khuri N, Giacomini K, Sali A. Molecular modeling and ligand docking for solute carrier (SLC) transporters. Curr Top Med Chem. 2013; 13(7):843-56. PMID: 23578028; PMCID: PMC4056341.
    44. Morrissey KM, Stocker SL, Wittwer MB, Xu L, Giacomini K. Renal transporters in drug development. Annu Rev Pharmacol Toxicol. 2013; 53:503-29. PMID: 23140242.
      View in: PubMed
    45. Zamek-Gliszczynski MJ, Hoffmaster KA, Tweedie DJ, Giacomini K, Hillgren KM. Highlights from the International Transporter Consortium second workshop. Clin Pharmacol Ther. 2012 Nov; 92(5):553-6. PMID: 23085880.
      View in: PubMed
    46. Morrissey KM, Wen CC, Johns SJ, Zhang L, Huang SM, Giacomini K. The UCSF-FDA TransPortal: a public drug transporter database. Clin Pharmacol Ther. 2012 Nov; 92(5):545-6. PMID: 23085876; PMCID: PMC3974775.
    47. Gong L, Goswami S, Giacomini K, Altman RB, Klein TE. Metformin pathways: pharmacokinetics and pharmacodynamics. Pharmacogenet Genomics. 2012 Nov; 22(11):820-7. PMID: 22722338; PMCID: PMC3651676.
    48. Stocker SL, Morrissey KM, Yee SW, Castro RA, Xu L, Dahlin A, Ramirez AH, Roden DM, Wilke RA, McCarty CA, Davis RL, Brett CM, Giacomini K. The effect of novel promoter variants in MATE1 and MATE2 on the pharmacokinetics and pharmacodynamics of metformin. Clin Pharmacol Ther. 2013 Feb; 93(2):186-94. PMID: 23267855; PMCID: PMC3671611.
    49. Giacomini KM, Yee SW, Ratain MJ, Weinshilboum RM, Kamatani N, Nakamura Y. Pharmacogenomics and patient care: one size does not fit all. Sci Transl Med. 2012 Sep 26; 4(153):153ps18. PMID: 23019654; PMCID: PMC3963516.
    50. Dubois SG, Geier E, Batra V, Yee SW, Neuhaus J, Segal M, Martinez D, Pawel B, Yanik G, Naranjo A, London WB, Kreissman S, Baker D, Attiyeh E, Hogarty MD, Maris JM, Giacomini K, Matthay KK. Evaluation of Norepinephrine Transporter Expression and Metaiodobenzylguanidine Avidity in Neuroblastoma: A Report from the Children's Oncology Group. Int J Mol Imaging. 2012; 2012:250834. PMID: 23050139; PMCID: PMC3463166.
    51. Schlessinger A, Wittwer MB, Dahlin A, Khuri N, Bonomi M, Fan H, Giacomini K, Sali A. High selectivity of the ?-aminobutyric acid transporter 2 (GAT-2, SLC6A13) revealed by structure-based approach. J Biol Chem. 2012 Nov 2; 287(45):37745-56. PMID: 22932902; PMCID: PMC3488050.
    52. Smith DE, Rowland M, Giacomini K, Amidon GL. Dedication to professor Leslie Z. Benet: 50 years of scientific excellence and still going strong! Pharm Res. 2012 Sep; 29(9):2345-53. PMID: 22814901.
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    53. Yee SW, Chen L, Giacomini K. The role of ATM in response to metformin treatment and activation of AMPK. Nat Genet. 2012 Apr; 44(4):359-60. PMID: 22456732; PMCID: PMC3359140.
    54. Chen L, Hong C, Chen EC, Yee SW, Xu L, Almof EU, Wen C, Fujii K, Johns SJ, Stryke D, Ferrin TE, Simko J, Chen X, Costello JF, Giacomini K. Genetic and epigenetic regulation of the organic cation transporter 3, SLC22A3. Pharmacogenomics J. 2013 Apr; 13(2):110-20. PMID: 22231567; PMCID: PMC3396779.
    55. Ramsey LB, Bruun GH, Yang W, Treviño LR, Vattathil S, Scheet P, Cheng C, Rosner GL, Giacomini K, Fan Y, Sparreboom A, Mikkelsen TS, Corydon TJ, Pui CH, Evans WE, Relling MV. Rare versus common variants in pharmacogenetics: SLCO1B1 variation and methotrexate disposition. Genome Res. 2012 Jan; 22(1):1-8. PMID: 22147369; PMCID: PMC3246196.
    56. Innocenti F, Owzar K, Cox NL, Evans P, Kubo M, Zembutsu H, Jiang C, Hollis D, Mushiroda T, Li L, Friedman P, Wang L, Glubb D, Hurwitz H, Giacomini K, McLeod HL, Goldberg RM, Schilsky RL, Kindler HL, Nakamura Y, Ratain MJ. A genome-wide association study of overall survival in pancreatic cancer patients treated with gemcitabine in CALGB 80303. Clin Cancer Res. 2012 Jan 15; 18(2):577-84. PMID: 22142827; PMCID: PMC3412624.
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    243. Giacomini K, Abang A, Blaschke TF. Calculation of drug concentration in plasma after equilibrium dialysis. Br J Clin Pharmacol. 1982 Nov; 14(5):752-4. PMID: 7138760; PMCID: PMC1427475.
    244. Pollick C, Giacomini K, Blaschke TF, Nelson WL, Turner-Tamiyasu K, Briskin V, Popp RL. The cardiac effects of d- and l-disopyramide in normal subjects: a noninvasive study. Circulation. 1982 Aug; 66(2):447-53. PMID: 7094252.
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    245. Smith GA, Schulz P, Giacomini K, Blaschke TF. High-pressure liquid chromatographic determination of amitriptyline and its major metabolites in human whole blood. J Pharm Sci. 1982 May; 71(5):581-3. PMID: 7097507.
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    246. Swezey SF, Giacomini K, Abang A, Brass C, Stevens DA, Blaschke TF. Measurement of ketoconazole, a new antifungal agent, by high-performance liquid chromatography. J Chromatogr. 1982 Feb 12; 227(2):510-5. PMID: 6277970.
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    247. Giacomini K, Swezey SE, Turner-Tamiyasu K, Blaschke TF. The effect of saturable binding to plasma proteins on the pharmacokinetic properties of disopyramide. J Pharmacokinet Biopharm. 1982 Feb; 10(1):1-14. PMID: 7069575.
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    248. Nelson WL, Sneed CK, Giacomini K, Giacomini JC, Stauss J, Blaschke TF, Cox BM. Synthesis and anticholinergic properties of the enantiomers of 4-(isopropylamino)-2-(2-pyridyl)-2-phenylbutyramide, the mono-N-dealkylated metabolite of disopyramide. J Med Chem. 1981 May; 24(5):614-7. PMID: 7241519.
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    249. Giacomini K, Roberts SM, Levy G. Evaluation of methods for producing renal dysfunction in rats. J Pharm Sci. 1981 Feb; 70(2):117-21. PMID: 7205211.
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    250. Giacomini K, Giacomini JC, Blaschke TF. Absence of effect of heparin on the binding of prazosin and phenytoin to plasma proteins. Biochem Pharmacol. 1980 Dec; 29(24):3337-40. PMID: 7213407.
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    251. Giacomini K, Giacomini JC, Swezey SE, Harrison DC, Nelson WL, Burke TR, Blaschke TF. The stereoselective disposition of disopyramide in the dog. J Cardiovasc Pharmacol. 1980 Nov-Dec; 2(6):825-32. PMID: 6160331.
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    252. Giacomini K, Cox BM, Blaschke TF. Comparative anticholinergic potencies of R- and S- disopyramide in longitudinal muscle strips from guinea pig ileum. Life Sci. 1980 Sep 29; 27(13):1191-7. PMID: 7421405.
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    253. Giacomini K, Giacomini JC, Gibson TP, Levy G. Propoxyphene and norpropoxyphene plasma concentrations after oral propoxyphene in cirrhotic patients with and without surgically constructed portacaval shunt. Clin Pharmacol Ther. 1980 Sep; 28(3):417-24. PMID: 7408401.
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    254. Giacomini K, Swezey SE, Giacomini JC, Blaschke TF. Administration of heparin causes in vitro release of non-esterified fatty acids in human plasma. Life Sci. 1980 Sep 1; 27(9):771-80. PMID: 7412503.
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    255. Giacomini K, Nakeeb SM, Levy G. Pharmacokinetic studies of propoxyphene I:Effect of portacaval shunt on systemic availability in dogs. J Pharm Sci. 1980 Jul; 69(7):786-9. PMID: 7391940.
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    256. Gibson TP, Giacomini K, Briggs WA, Whitman W, Levy G. Propoxyphene and norpropoxyphene plasma concentrations in the anephric patient. Clin Pharmacol Ther. 1980 May; 27(5):665-70. PMID: 7371364.
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    257. Giacomini K, Gibson TP, Levy G. Effect of hemodialysis on propoxyphene and norpropoxyphene concentrations in blood of anephric patients. Clin Pharmacol Ther. 1980 Apr; 27(4):508-14. PMID: 7357810.
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    258. Jones MR, Kopple JD, Swendseid ME. Phenylalanine metabolism in uremic and normal man. Kidney Int. 1978 Aug; 14(2):169-79. PMID: 357810.
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    259. Levy G, Giacomini K. Rational aspirin dosage regimens. Clin Pharmacol Ther. 1978 Mar; 23(3):247-52. PMID: 627128.
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    260. Giacomini K, Gibson TP, Levy G. Plasma protein binding of d-propoxyphene in normal subjects and anephric patients. J Clin Pharmacol. 1978 Feb-Mar; 18(2-3):106-9. PMID: 624774.
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    261. Soles C, Giacomini KM, Roberts SM, Giacomini JC. Soles C, Giacomini KM, Roberts SM, Giacomini JC. A Convenient Method for Repetitive Blood Sampling in the Dog. J. Pharmacol. Meth. 1978; (1):259-261.
    262. Senet JM, Robert R, Mauras G. [Diagnosis of toxoplasmosis by indirect hemagglutination. II. Value of mixed total antigen fixation in the presence of glutaraldehyde in the early diagnosis of the disease]. Biomedicine. 1976 Jul; 25(6):212-4. PMID: 822893.
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