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    Annette Molinaro, PhD

    TitleAssociate Professor
    SchoolUCSF School of Medicine
    DepartmentNeurological Surgery
    Address400 Parnassus Ave, UC Clinics
    San Francisco CA 94143
    Phone415-353-2136

       Biography 
       Awards and Honors
      UCSF2013Diane D. Ralston Clinical and Basic Neuroscience Teaching Award
      Yale University School of Public Health2008Teacher of the Year Award
      International Statistical Institute2006Elected as a Member
      University of California, Berkeley2004Chin Long Chiang Biostatistics Student of the Year
      University of California, Berkeley2004Evelyn Fix Prize

       Overview 
       Overview
      Dr. Molinaro is a principal investigator in the Brain Tumor Research Center at UCSF and the Co-Director of the Clinical and Biostatistics Core for the newly funded UCSF Brain SPORE as well as the Co-Director of the Biospecimen and Biostatistics Core for the newly funded UCSF Brain P01. Dr. Molinaro’s research interests are primarily focused on statistical genetics and computational biology, including prediction, survival analysis and classification with additional curiosities in cancer epidemiology and in the estimation of absolute risk in stratified case-cohort studies. Her research has pertained to predicting clinical outcomes with high-dimensional explanatory variables, such as SNP and methylation arrays, and large-scale epidemiology studies. This has included an adaptation to Classification and Regression Trees (CART) for survival outcomes, the introduction of partDSA, a novel data-adaptive algorithm that builds Boolean combinations of explanatory variables, and a non-parametric method for point estimation based on a stratified case-cohort study design. Dr. Molinaro was recently awarded an R01 by the NCI to expand partDSA for building risk models accommodating various study designs and competing risks. In addition, she has worked with collaborators at the National Cancer Institute (NCI) on comparing cross-validation approaches to validating predictors in small sample sizes and the power of data mining methods for detecting genetic associations and interactions.


       ORNG Applications 
       Featured Publications
       Websites
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       Bibliographic 
       Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Ferrucci LM, Cartmel B, Molinaro AM, Leffell DJ, Bale AE, Mayne ST. Tea, coffee, and caffeine and early-onset basal cell carcinoma in a case-control study. Eur J Cancer Prev. 2014 Jul; 23(4):296-302.
        View in: PubMed
      2. Clarke JL, Molinaro AM, Phillips JJ, Butowski NA, Chang SM, Perry A, Costello JF, DeSilva AA, Rabbitt JE, Prados MD. A single-institution phase II trial of radiation, temozolomide, erlotinib, and bevacizumab for initial treatment of glioblastoma. Neuro Oncol. 2014 Jul; 16(7):984-90.
        View in: PubMed
      3. Walsh KM, Codd V, Smirnov IV, Rice T, Decker PA, Hansen HM, Kollmeyer T, Kosel ML, Molinaro AM, McCoy LS, Bracci PM, Cabriga BS, Pekmezci M, Zheng S, Wiemels JL, Pico AR, Tihan T, Berger MS, Chang SM, Prados MD, Lachance DH, O'Neill BP, Sicotte H, Eckel-Passow JE. Variants near TERT and TERC influencing telomere length are associated with high-grade glioma risk. Nat Genet. 2014 Jun 8.
        View in: PubMed
      4. Han SJ, Rolston JD, Molinaro AM, Clarke JL, Prados MD, Chang SM, Berger MS, DeSilva A, Butowski NA. Phase II trial of 7 days on/7 days off temozolmide for recurrent high-grade glioma. Neuro Oncol. 2014 Sep; 16(9):1255-62.
        View in: PubMed
      5. Han SJ, Rolston JD, Molinaro AM, Clarke JL, Prados MD, Chang SM, Berger MS, DeSilva A, Butowski NA. Phase II trial of 7 days on/7 days off temozolmide for recurrent high-grade glioma. Neuro Oncol. 2014 Sep; 16(9):1255-62.
        View in: PubMed
      6. Moore CL, Bomann S, Daniels B, Luty S, Molinaro A, Singh D, Gross CP. Derivation and validation of a clinical prediction rule for uncomplicated ureteral stone--the STONE score: retrospective and prospective observational cohort studies. BMJ. 2014; 348:g2191.
        View in: PubMed
      7. Herbst MK, Rosenberg G, Daniels B, Gross CP, Singh D, Molinaro AM, Luty S, Moore CL. Effect of provider experience on clinician-performed ultrasonography for hydronephrosis in patients with suspected renal colic. Ann Emerg Med. 2014 Sep; 64(3):269-76.
        View in: PubMed
      8. Elkhaled A, Jalbert L, Constantin A, Yoshihara HA, Phillips JJ, Molinaro AM, Chang SM, Nelson SJ. Characterization of metabolites in infiltrating gliomas using ex vivo (1) H high-resolution magic angle spinning spectroscopy. NMR Biomed. 2014 May; 27(5):578-93.
        View in: PubMed
      9. Potts MB, Shah JK, Molinaro AM, Blevins LS, Tyrrell JB, Kunwar S, Dowd CF, Hetts SW, Aghi MK. Cavernous and inferior petrosal sinus sampling and dynamic magnetic resonance imaging in the preoperative evaluation of Cushing's disease. J Neurooncol. 2014 Feb; 116(3):593-600.
        View in: PubMed
      10. Sun MZ, Ivan ME, Clark AJ, Oh MC, Delance AR, Oh T, Safaee M, Kaur G, Bloch O, Molinaro A, Gupta N, Parsa AT. Gross total resection improves overall survival in children with choroid plexus carcinoma. J Neurooncol. 2014 Jan; 116(1):179-85.
        View in: PubMed
      11. Wang DD, Ouyang D, Englot DJ, Rolston JD, Molinaro AM, Ward M, Chang EF. Trends in surgical treatment for trigeminal neuralgia in the United States of America from 1988 to 2008. J Clin Neurosci. 2013 Nov; 20(11):1538-45.
        View in: PubMed
      12. Walsh KM, Rice T, Decker PA, Kosel ML, Kollmeyer T, Hansen HM, Zheng S, McCoy LS, Bracci PM, Anderson E, Hsuang G, Wiemels JL, Pico AR, Smirnov I, Molinaro AM, Tihan T, Berger MS, Chang SM, Prados MD, Lachance DH, Sicotte H, Eckel-Passow JE, Wiencke JK, Jenkins RB, Wrensch MR. Genetic variants in telomerase-related genes are associated with an older age at diagnosis in glioma patients: evidence for distinct pathways of gliomagenesis. Neuro Oncol. 2013 Aug; 15(8):1041-7.
        View in: PubMed
      13. Moore CL, Daniels B, Singh D, Luty S, Molinaro A. Prevalence and clinical importance of alternative causes of symptoms using a renal colic computed tomography protocol in patients with flank or back pain and absence of pyuria. Acad Emerg Med. 2013 May; 20(5):470-8.
        View in: PubMed
      14. Safaee M, Oh MC, Sughrue ME, Delance AR, Bloch O, Sun M, Kaur G, Molinaro AM, Parsa AT. The relative patient benefit of gross total resection in adult choroid plexus papillomas. J Clin Neurosci. 2013 Jun; 20(6):808-12.
        View in: PubMed
      15. Phillips JJ, Aranda D, Ellison DW, Judkins AR, Croul SE, Brat DJ, Ligon KL, Horbinski C, Venneti S, Zadeh G, Santi M, Zhou S, Appin CL, Sioletic S, Sullivan LM, Martinez-Lage M, Robinson AE, Yong WH, Cloughesy T, Lai A, Phillips HS, Marshall R, Mueller S, Haas-Kogan DA, Molinaro AM, Perry A. PDGFRA amplification is common in pediatric and adult high-grade astrocytomas and identifies a poor prognostic group in IDH1 mutant glioblastoma. Brain Pathol. 2013 Sep; 23(5):565-73.
        View in: PubMed
      16. Mueller S, Bhargava S, Molinaro AM, Yang X, Kolkowitz I, Olow A, Wehmeijer N, Orbach S, Chen J, Matthay KK, Haas-Kogan DA. Poly (ADP-Ribose) polymerase inhibitor MK-4827 together with radiation as a novel therapy for metastatic neuroblastoma. Anticancer Res. 2013 Mar; 33(3):755-62.
        View in: PubMed
      17. Lupo JM, Essock-Burns E, Molinaro AM, Cha S, Chang SM, Butowski N, Nelson SJ. Using susceptibility-weighted imaging to determine response to combined anti-angiogenic, cytotoxic, and radiation therapy in patients with glioblastoma multiforme. Neuro Oncol. 2013 Apr; 15(4):480-9.
        View in: PubMed
      18. Oh MC, Kim JM, Kaur G, Safaee M, Sun MZ, Singh A, Aranda D, Molinaro AM, Parsa AT. Prognosis by tumor location in adults with spinal ependymomas. J Neurosurg Spine. 2013 Mar; 18(3):226-35.
        View in: PubMed
      19. Oh MC, Sayegh ET, Safaee M, Sun MZ, Kaur G, Kim JM, Aranda D, Molinaro AM, Gupta N, Parsa AT. Prognosis by tumor location for pediatric spinal cord ependymomas. J Neurosurg Pediatr. 2013 Mar; 11(3):282-8.
        View in: PubMed
      20. Essock-Burns E, Phillips JJ, Molinaro AM, Lupo JM, Cha S, Chang SM, Nelson SJ. Comparison of DSC-MRI post-processing techniques in predicting microvascular histopathology in patients newly diagnosed with GBM. J Magn Reson Imaging. 2013 Aug; 38(2):388-400.
        View in: PubMed
      21. Chakravarti A, Wang M, Robins HI, Lautenschlaeger T, Curran WJ, Brachman DG, Schultz CJ, Choucair A, Dolled-Filhart M, Christiansen J, Gustavson M, Molinaro A, Mischel P, Dicker AP, Bredel M, Mehta M. RTOG 0211: a phase 1/2 study of radiation therapy with concurrent gefitinib for newly diagnosed glioblastoma patients. Int J Radiat Oncol Biol Phys. 2013 Apr 1; 85(5):1206-11.
        View in: PubMed
      22. Engler JR, Robinson AE, Smirnov I, Hodgson JG, Berger MS, Gupta N, James CD, Molinaro A, Phillips JJ. Increased microglia/macrophage gene expression in a subset of adult and pediatric astrocytomas. PLoS One. 2012; 7(8):e43339.
        View in: PubMed
      23. Barajas RF, Phillips JJ, Parvataneni R, Molinaro A, Essock-Burns E, Bourne G, Parsa AT, Aghi MK, McDermott MW, Berger MS, Cha S, Chang SM, Nelson SJ. Regional variation in histopathologic features of tumor specimens from treatment-naive glioblastoma correlates with anatomic and physiologic MR Imaging. Neuro Oncol. 2012 Jul; 14(7):942-54.
        View in: PubMed
      24. Lostritto K, Strawderman RL, Molinaro AM. A partitioning deletion/substitution/addition algorithm for creating survival risk groups. Biometrics. 2012 Dec; 68(4):1146-56.
        View in: PubMed
      25. Hu YL, DeLay M, Jahangiri A, Molinaro AM, Rose SD, Carbonell WS, Aghi MK. Hypoxia-induced autophagy promotes tumor cell survival and adaptation to antiangiogenic treatment in glioblastoma. Cancer Res. 2012 Apr 1; 72(7):1773-83.
        View in: PubMed
      26. Baquero MT, Hanna JA, Neumeister V, Cheng H, Molinaro AM, Harris LN, Rimm DL. Stathmin expression and its relationship to microtubule-associated protein tau and outcome in breast cancer. Cancer. 2012 Oct 1; 118(19):4660-9.
        View in: PubMed
      27. Lostritto K, Ferrucci LM, Cartmel B, Leffell DJ, Molinaro AM, Bale AE, Mayne ST. Lifetime history of indoor tanning in young people: a retrospective assessment of initiation, persistence, and correlates. BMC Public Health. 2012; 12:118.
        View in: PubMed
      28. Ferrucci LM, Cartmel B, Molinaro AM, Leffell DJ, Bale AE, Mayne ST. Indoor tanning and risk of early-onset basal cell carcinoma. J Am Acad Dermatol. 2012 Oct; 67(4):552-62.
        View in: PubMed
      29. Ferrucci LM, Cartmel B, Molinaro AM, Gordon PB, Leffell DJ, Bale AE, Mayne ST. Host phenotype characteristics and MC1R in relation to early-onset basal cell carcinoma. J Invest Dermatol. 2012 Apr; 132(4):1272-9.
        View in: PubMed
      30. Baquero MT, Lostritto K, Gustavson MD, Bassi KA, Appia F, Camp RL, Molinaro AM, Harris LN, Rimm DL. Evaluation of prognostic and predictive value of microtubule associated protein tau in two independent cohorts. Breast Cancer Res. 2011; 13(5):R85.
        View in: PubMed
      31. Potts MB, Smith JS, Molinaro AM, Berger MS. Natural history and surgical management of incidentally discovered low-grade gliomas. J Neurosurg. 2012 Feb; 116(2):365-72.
        View in: PubMed
      32. Molinaro AM, Carriero N, Bjornson R, Hartge P, Rothman N, Chatterjee N. Power of data mining methods to detect genetic associations and interactions. Hum Hered. 2011; 72(2):85-97.
        View in: PubMed
      33. Jahangiri A, Molinaro AM, Tarapore PE, Blevins L, Auguste KI, Gupta N, Kunwar S, Aghi MK. Rathke cleft cysts in pediatric patients: presentation, surgical management, and postoperative outcomes. Neurosurg Focus. 2011 Jul; 31(1):E3.
        View in: PubMed
      34. Tolles J, Bai Y, Baquero M, Harris LN, Rimm DL, Molinaro AM. Optimal tumor sampling for immunostaining of biomarkers in breast carcinoma. Breast Cancer Res. 2011; 13(3):R51.
        View in: PubMed
      35. Bai Y, Tolles J, Cheng H, Siddiqui S, Gopinath A, Pectasides E, Camp RL, Rimm DL, Molinaro AM. Quantitative assessment shows loss of antigenic epitopes as a function of pre-analytic variables. Lab Invest. 2011 Aug; 91(8):1253-61.
        View in: PubMed
      36. Kluger HM, Hoyt K, Bacchiocchi A, Mayer T, Kirsch J, Kluger Y, Sznol M, Ariyan S, Molinaro A, Halaban R. Plasma markers for identifying patients with metastatic melanoma. Clin Cancer Res. 2011 Apr 15; 17(8):2417-25.
        View in: PubMed
      37. Martin KD, Naert L, Goldstein LB, Kasl S, Molinaro AM, Lichtman JH. Comparing the use of diagnostic imaging and receipt of carotid endarterectomy in elderly black and white stroke patients. J Stroke Cerebrovasc Dis. 2012 Oct; 21(7):600-6.
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      38. Pelizzola M, Molinaro A. Methylated DNA immunoprecipitation genome-wide analysis. Methods Mol Biol. 2011; 791:113-23.
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      39. Godshalk SE, Paranjape T, Nallur S, Speed W, Chan E, Molinaro AM, Bacchiocchi A, Hoyt K, Tworkoski K, Stern DF, Sznol M, Ariyan S, Lazova R, Halaban R, Kidd KK, Weidhaas JB, Slack FJ. A Variant in a MicroRNA complementary site in the 3' UTR of the KIT oncogene increases risk of acral melanoma. Oncogene. 2011 Mar 31; 30(13):1542-50.
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      40. Kluger HM, Dudek AZ, McCann C, Ritacco J, Southard N, Jilaveanu LB, Molinaro A, Sznol M. A phase 2 trial of dasatinib in advanced melanoma. Cancer. 2011 May 15; 117(10):2202-8.
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      41. Kerlikowske K, Molinaro AM, Gauthier ML, Berman HK, Waldman F, Bennington J, Sanchez H, Jimenez C, Stewart K, Chew K, Ljung BM, Tlsty TD. Biomarker expression and risk of subsequent tumors after initial ductal carcinoma in situ diagnosis. J Natl Cancer Inst. 2010 May 5; 102(9):627-37.
        View in: PubMed
      42. Molinaro AM, Lostritto K, van der Laan M. partDSA: deletion/substitution/addition algorithm for partitioning the covariate space in prediction. Bioinformatics. 2010 May 15; 26(10):1357-63.
        View in: PubMed
      43. Molinaro AM and Lostritto K. STATISTICALBIOINFORMATICS: A GUIDE FOR LIFE AND BIOMEDICAL SCIENCE RESEARCHERS. Ed. Jae K. Lee. Statistical resampling for large screening data analysis such as classical resampling Bootstrapping, Markov chain Monte Carlo, and statistical simulation and validation strategies. 2010.
      44. Gould Rothberg BE, Berger AJ, Molinaro AM, Subtil A, Krauthammer MO, Camp RL, Bradley WR, Ariyan S, Kluger HM, Rimm DL. Melanoma prognostic model using tissue microarrays and genetic algorithms. J Clin Oncol. 2009 Dec 1; 27(34):5772-80.
        View in: PubMed
      45. Koga Y, Pelizzola M, Cheng E, Krauthammer M, Sznol M, Ariyan S, Narayan D, Molinaro AM, Halaban R, Weissman SM. Genome-wide screen of promoter methylation identifies novel markers in melanoma. Genome Res. 2009 Aug; 19(8):1462-70.
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      46. Halaban R, Krauthammer M, Pelizzola M, Cheng E, Kovacs D, Sznol M, Ariyan S, Narayan D, Bacchiocchi A, Molinaro A, Kluger Y, Deng M, Tran N, Zhang W, Picardo M, Enghild JJ. Integrative analysis of epigenetic modulation in melanoma cell response to decitabine: clinical implications. PLoS One. 2009; 4(2):e4563.
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      47. Erickson AH, Wise A, Fleming S, Molinaro AM, Teboh-Ewungkem M, Baird M, Lateef Z, and de Pillis L. A preliminary mathematical model of skin dendritic cell trafficking and induction of t-cell immunity. Discrete and Continuous Dynamical Systems - Series B (DCDS-B): Special Issue on Mathematical Biology and Medicine. 2009; 12(2).
      48. Gustavson MD, Molinaro AM, Tedeschi G, Camp RL, Rimm DL. AQUA analysis of thymidylate synthase reveals localization to be a key prognostic biomarker in 2 large cohorts of colorectal carcinoma. Arch Pathol Lab Med. 2008 Nov; 132(11):1746-52.
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      49. Giltnane JM, Molinaro A, Cheng H, Robinson A, Turbin D, Gelmon K, Huntsman D, Rimm DL. Comparison of quantitative immunofluorescence with conventional methods for HER2/neu testing with respect to response to trastuzumab therapy in metastatic breast cancer. Arch Pathol Lab Med. 2008 Oct; 132(10):1635-47.
        View in: PubMed
      50. Pelizzola M, Koga Y, Urban AE, Krauthammer M, Weissman S, Halaban R, Molinaro AM. MEDME: an experimental and analytical methodology for the estimation of DNA methylation levels based on microarray derived MeDIP-enrichment. Genome Res. 2008 Oct; 18(10):1652-9.
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      51. Ghosh S, Sullivan CA, Zerkowski MP, Molinaro AM, Rimm DL, Camp RL, Chung GG. High levels of vascular endothelial growth factor and its receptors (VEGFR-1, VEGFR-2, neuropilin-1) are associated with worse outcome in breast cancer. Hum Pathol. 2008 Dec; 39(12):1835-43.
        View in: PubMed
      52. Kluger HM, Siddiqui SF, Angeletti C, Sznol M, Kelly WK, Molinaro AM, Camp RL. Classification of renal cell carcinoma based on expression of VEGF and VEGF receptors in both tumor cells and endothelial cells. Lab Invest. 2008 Sep; 88(9):962-72.
        View in: PubMed
      53. Petersen ML, Molinaro AM, Sinisi SE, van der Laan MJ. Cross-Validated Bagged Learning. J Multivar Anal. 2008 Mar; 25(2):260-266.
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      54. Moeder CB, Giltnane JM, Harigopal M, Molinaro A, Robinson A, Gelmon K, Huntsman D, Camp RL, Rimm DL. Quantitative justification of the change from 10% to 30% for human epidermal growth factor receptor 2 scoring in the American Society of Clinical Oncology/College of American Pathologists guidelines: tumor heterogeneity in breast cancer and its implications for tissue microarray based assessment of outcome. J Clin Oncol. 2007 Dec 1; 25(34):5418-25.
        View in: PubMed
      55. White SD, Affolter VK, Schultheiss PC, Ball BA, Wessel MT, Kass P, Molinaro AM, Bannasch DL, Ihrke PJ. Clinical and pathological findings in a HERDA-affected foal for 1.5 years of life. Vet Dermatol. 2007 Feb; 18(1):36-40.
        View in: PubMed
      56. Moore LE, Fung ET, McGuire M, Rabkin CC, Molinaro A, Wang Z, Zhang F, Wang J, Yip C, Meng XY, Pfeiffer RM. Evaluation of apolipoprotein A1 and posttranslationally modified forms of transthyretin as biomarkers for ovarian cancer detection in an independent study population. Cancer Epidemiol Biomarkers Prev. 2006 Sep; 15(9):1641-6.
        View in: PubMed
      57. Hothorn T, Bühlmann P, Dudoit S, Molinaro A, van der Laan MJ. Survival ensembles. Biostatistics. 2006 Jul; 7(3):355-73.
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      58. Molinaro AM, Simon R, Pfeiffer RM. Prediction error estimation: a comparison of resampling methods. Bioinformatics. 2005 Aug 1; 21(15):3301-7.
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      59. Molinaro AM, Dudoit S, and van der Laan MJ. Tree-based multivariate regression and density estimation with right-censored data. Journal of Multivariate Analysis. 2004; 90(1):154-177.
      60. Kerlikowske K, Molinaro A, Cha I, Ljung BM, Ernster VL, Stewart K, Chew K, Moore DH, Waldman F. Characteristics associated with recurrence among women with ductal carcinoma in situ treated by lumpectomy. J Natl Cancer Inst. 2003 Nov 19; 95(22):1692-702.
        View in: PubMed
      61. Dudoit S, van der Laan MJ, Keles¸ S, Molinaro AM, Sinisi S, and Teng SL. Loss-based estimation with cross-validation: Applications to microarray data analysis and motif finding. SIGKDD Explorations. 2003; 5(2):37-49.
      62. Aust DE, Terdiman JP, Willenbucher RF, Chang CG, Molinaro AM, Baretton GB, Loehrs U, and Waldman FM. The apc/beta-catenin pathway in ulcerative colitis-related colorectal carcinomas: A mutational analysis. Cancer. 2002; 94(5):1421-7.
      63. Etzell JE, Devries S, Chew K, Florendo C, Molinaro A, Ljung BM, Waldman FM. Loss of chromosome 16q in lobular carcinoma in situ. Hum Pathol. 2001 Mar; 32(3):292-6.
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      64. Aust DE, Terdiman JP, Willenbucher RF, Chew K, Ferrell L, Florendo C, Molinaro AM, Baretton GB, Loehrs U, Waldman, FM. Altered Distribution of beta-catenin, and its binding proteins E-cadherin and APC, in Ulcerative Colitis-Related Colorectal Cancers. Modern Pathology. 2001; 14:29-39.
      65. Aust DE, Willenbucher RF, Terdiman JP, Ferrell LD, Chang CG, Moore DH, Molinaro AM, Baretton GB, Loehrs U, Waldman FM. Chromosomal Alterations in Ulcerative Colitis-Related and Sporadic Colorectal Cancers by Comparative Genomic Hybridization. Human Pathology. 2000; 31(1):109-114.
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