Sam Pleasure, MD, PhD

Title(s)Professor, Neurology
SchoolSchool of Medicine
Address675 Nelson Rising Lane, #214
San Francisco CA 94158
Phone415-514-4949
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    Other Positions
    Title(s)UCSF Weill Institute for Neurosciences


    Collapse Biography 
    Collapse Education and Training
    University of PennsylvaniaBA1986Biology/Medieval Studies
    University of PennsylvaniaM.D.1993School of Medicine
    University of PennsylvaniaPh.D.1993Neuroscience
    University of California, San FranciscoResidency 1997School of Medicine

    Collapse Overview 
    Collapse Overview
    Dr. Samuel J. Pleasure is a neurologist who specializes in caring for patients with multiple sclerosis. He also has expertise in caring for patients with epilepsy as well as years of experience in managing a variety of neurological conditions in both clinic and hospital settings.

    Pleasure has two main areas of inquiry for his research. He studies processes that regulate early brain development in both normal and diseased situations. He also studies autoimmune forms of meningoencephalitis, where inflammation in specific brain areas causes severe neurologic dysfunction.

    Pleasure received his medical degree and a doctorate in neuroscience from the University of Pennsylvania. He was chief resident during his neurology residency at UCSF, where he then completed a research fellowship in neuroscience.

    Pleasure is a fellow of the American Neurological Association and a member of the American Academy of Neurology, American Epilepsy Society, Society for Neuroscience, Society for Developmental Biology and Cajal Club. He has won numerous awards for his research and has received research funding from a wide variety of private, state and federal sources. He has served in leadership roles in national organizations and in the UCSF Department of Neurology.

    Pleasure is the Glenn W. Johnson, Jr. Memorial Endowed Chair in Neurology at UCSF.

    Collapse Research 
    Collapse Research Activities and Funding
    Predoctoral Training in Neurobiology
    NIH T32NS115706Jul 15, 2020 - Jun 30, 2025
    Role: Principal Investigator
    NMDA receptors and callosal circuitry: development and molecular mechanisms
    NIH R01MH119435Jul 1, 2020 - Apr 30, 2024
    Role: Principal Investigator
    Autoimmune Encephalitis - Ataxia and Psychiatric Disease: Identifying and Characterizing Novel Antibody Targets
    NIH R01MH122471Apr 16, 2020 - Jan 31, 2025
    Role: Principal Investigator
    Description: This is a multi-PI grant with three PI's - Pleasure, Wilson, DeRisi
    Autoantibody Discovery in Neuropsychiatric Disease
    Brain Research Foundation Scientific Innovations AwardJan 1, 2020 - Dec 31, 2021
    Role: Principal Investigator
    Control of dentate neurogenesis: Shh, mossy cells, activity and seizures
    NIH R01NS118995Sep 1, 2007 - Mar 31, 2025
    Role: Principal Investigator
    Forced Differentiation of CNS Neural Precursors in vitro and in vivo
    NIH R21NS055783Mar 1, 2007 - Feb 28, 2009
    Role: Principal Investigator
    Wnt Signaling in Hippocampal and Neocortical Development
    NIH K02MH074958Jul 1, 2005 - Jun 30, 2010
    Role: Principal Investigator
    Wnt Signaling in Hippocampal &Neocortical Development
    NIH R01MH066084Jul 1, 2003 - Jun 30, 2008
    Role: Principal Investigator
    Regulation of Hippocampal Development by Wnt Signaling
    NIH K08NS002208Sep 20, 2000 - Jun 30, 2005
    Role: Principal Investigator
    Defective Forebrain Development in Mutant Mice
    NIH R01MH105360Feb 1, 1998 - Mar 31, 2016
    Role: Principal Investigator
    Mechanisms of Ischemic Neonatal Brain Injury
    NIH P50NS035902Apr 1, 1997 - Jan 31, 2015
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Collaboration Interests

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Shh from mossy cells contributes to preventing NSC pool depletion after seizure-induced neurogenesis and in aging. Elife. 2023 Dec 11; 12. Noguchi H, Arela JC, Ngo T, Cocas L, Pleasure S. PMID: 38079471; PMCID: PMC10712957.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    2. Expanding Spectrum and Therapeutic Insights in Inflammatory Brain Disorders. Dev Neurosci. 2023; 45(6):313-314. Pleasure SJ. PMID: 37935157; PMCID: PMC10668618.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Neuronal Activity Changes the Number of Neurons That Are Synaptically Connected to OPCs. eNeuro. 2023 10; 10(10). Moura D, Parvathaneni A, Sahagun A, Noguchi H, Garcia J, Brennan E, Brock R, Tilton I, Halladay L, Pleasure S, Cocas L. PMID: 37813563; PMCID: PMC10598642.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    4. Detection of High-Risk Paraneoplastic Antibodies against TRIM9 and TRIM67 Proteins. Ann Neurol. 2023 12; 94(6):1086-1101. Bartley CM, Ngo TT, Do LD, Zekeridou A, Dandekar R, Muñiz-Castrillo S, Alvarenga BD, Zorn KC, Tubati A, Pinto AL, Browne WD, Hullett PW, Terrelonge M, Schubert RD, Piquet AL, Yang B, Montalvo M, Kung AF, Mann SA, Shah MP, Geschwind MD, Gelfand JM, DeRisi JL, Pittock SJ, Honnorat J, Pleasure SJ, Wilson MR. PMID: 37632288; PMCID: PMC10842626.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. CaMKII autophosphorylation but not downstream kinase activity is required for synaptic memory. bioRxiv. 2023 Aug 26. Chen X, Cai Q, Zhou J, Pleasure SJ, Schulman H, Zhang M, Nicoll RA. PMID: 37662326; PMCID: PMC10473743.
      View in: PubMed   Mentions:
    6. Shh from mossy cells contributes to preventing NSC pool depletion after seizure-induced neurogenesis and in aging. bioRxiv. 2023 Aug 22. Noguchi H, Arela JC, Ngo TT, Cocas L, Pleasure SJ. PMID: 37662214; PMCID: PMC10473584.
      View in: PubMed   Mentions:
    7. Viral co-infection, autoimmunity, and CSF HIV antibody profiles in HIV central nervous system escape. J Neuroimmunol. 2023 08 15; 381:578141. Hawes IA, Alvarenga BD, Browne W, Wapniarski A, Dandekar R, Bartley CM, Sowa GM, DeRisi JL, Cinque P, Dravid AN, Pleasure SJ, Gisslen M, Price RW, Wilson MR. PMID: 37418948.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    8. Synchrony 2022: Epilepsy and Seizures in Autism Spectrum Disorder Roundtable. J Pers Med. 2023 Mar 20; 13(3). Frye RE, Nanda H, Pleasure SJ, Casanova MF, Boles RG, Lewine J, Gaitanis J, Adams JB. PMID: 36983738; PMCID: PMC10052130.
      View in: PubMed   Mentions:
    9. Dual ankyrinG and subpial autoantibodies in a man with well-controlled HIV infection with steroid-responsive meningoencephalitis: A case report. Front Neurol. 2022; 13:1102484. Bartley CM, Ngo TT, Cadwell CR, Harroud A, Schubert RD, Alvarenga BD, Hawes IA, Zorn KC, Hunyh T, Teliska LH, Kung AF, Shah S, Gelfand JM, Chow FC, Rasband MN, Dubey D, Pittock SJ, DeRisi JL, Wilson MR, Pleasure SJ. PMID: 36756346; PMCID: PMC9900111.
      View in: PubMed   Mentions: 2  
    10. Brain heterotopia formation by ciliopathic breakdown of neuroepithelial and blood-cerebrospinal fluid barriers. Brain Pathol. 2023 07; 33(4):e13148. Jung HJ, Yeo S, Jang J, Pleasure S, Choe Y. PMID: 36623505; PMCID: PMC10307530.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    11. Anti-SARS-CoV-2 and Autoantibody Profiling of a COVID-19 Patient With Subacute Psychosis Who Remitted After Treatment With Intravenous Immunoglobulin. Biol Psychiatry. 2023 05 01; 93(9):e25-e29. McAlpine LS, Lifland B, Check JR, Angarita GA, Ngo TT, Chen P, Dandekar R, Alvarenga BD, Browne WD, Pleasure SJ, Wilson MR, Spudich SS, Farhadian SF, Bartley CM. PMID: 36481066; PMCID: PMC9722219.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    12. The CRHR1/CREB/REST signaling cascade regulates mammalian embryonic neural stem cell properties. EMBO Rep. 2023 02 06; 24(2):e55313. Kwon M, Lee JH, Yoon Y, Pleasure SJ, Yoon K. PMID: 36413000; PMCID: PMC9900344.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    13. ZSCAN1 Autoantibodies Are Associated with Pediatric Paraneoplastic ROHHAD. Ann Neurol. 2022 08; 92(2):279-291. Mandel-Brehm C, Benson LA, Tran B, Kung AF, Mann SA, Vazquez SE, Retallack H, Sample HA, Zorn KC, Khan LM, Kerr LM, McAlpine PL, Zhang L, McCarthy F, Elias JE, Katwa U, Astley CM, Tomko S, Dalmau J, Seeley WW, Pleasure SJ, Wilson MR, Gorman MP, DeRisi JL. PMID: 35466441; PMCID: PMC9329235.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    14. βIV-Spectrin Autoantibodies in 2 Individuals With Neuropathy of Possible Paraneoplastic Origin: A Case Series. Neurol Neuroimmunol Neuroinflamm. 2022 07; 9(4). Bartley CM, Ngo TT, Alvarenga BD, Kung AF, Teliska LH, Sy M, DeRisi JL, Rasband MN, Pittock SJ, Dubey D, Wilson MR, Pleasure SJ. PMID: 35581007; PMCID: PMC9128026.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    15. Corrigendum: Case Report: A False Negative Case of Anti-Yo Paraneoplastic Myelopathy. Front Neurol. 2022; 13:888513. Bartley CM, Parikshak NN, Ngo TT, Alexander JA, Zorn KC, Alvarenga BD, Kang MK, Pedriali M, Pleasure SJ, Wilson MR. PMID: 35401388; PMCID: PMC8988224.
      View in: PubMed   Mentions:
    16. Risk factors and abnormal cerebrospinal fluid associate with cognitive symptoms after mild COVID-19. Ann Clin Transl Neurol. 2022 02; 9(2):221-226. Apple AC, Oddi A, Peluso MJ, Asken BM, Henrich TJ, Kelly JD, Pleasure SJ, Deeks SG, Allen IE, Martin JN, Ndhlovu LC, Miller BL, Stephens ML, Hellmuth J. PMID: 35043593; PMCID: PMC8862406.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    17. Synaptic memory requires CaMKII. Elife. 2021 12 15; 10. Tao W, Lee J, Chen X, Díaz-Alonso J, Zhou J, Pleasure S, Nicoll RA. PMID: 34908526; PMCID: PMC8798046.
      View in: PubMed   Mentions: 20     Fields:    
    18. Anti-SARS-CoV-2 and Autoantibody Profiles in the Cerebrospinal Fluid of 3 Teenaged Patients With COVID-19 and Subacute Neuropsychiatric Symptoms. JAMA Neurol. 2021 12 01; 78(12):1503-1509. Bartley CM, Johns C, Ngo TT, Dandekar R, Loudermilk RL, Alvarenga BD, Hawes IA, Zamecnik CR, Zorn KC, Alexander JR, Wapniarski AE, DeRisi JL, Francisco C, Nash KB, Wietstock SO, Pleasure SJ, Wilson MR. PMID: 34694339; PMCID: PMC8546622.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimals
    19. Case Report: A False Negative Case of Anti-Yo Paraneoplastic Myelopathy. Front Neurol. 2021; 12:728700. Bartley CM, Parikshak NN, Ngo TT, Alexander JA, Zorn KC, Alvarenga BA, Kang MK, Pedriali M, Pleasure SJ, Wilson MR. PMID: 34744969; PMCID: PMC8570369.
      View in: PubMed   Mentions: 2  
    20. Divergent and self-reactive immune responses in the CNS of COVID-19 patients with neurological symptoms. Cell Rep Med. 2021 05 18; 2(5):100288. Song E, Bartley CM, Chow RD, Ngo TT, Jiang R, Zamecnik CR, Dandekar R, Loudermilk RP, Dai Y, Liu F, Sunshine S, Liu J, Wu W, Hawes IA, Alvarenga BD, Huynh T, McAlpine L, Rahman NT, Geng B, Chiarella J, Goldman-Israelow B, Vogels CBF, Grubaugh ND, Casanovas-Massana A, Phinney BS, Salemi M, Alexander JR, Gallego JA, Lencz T, Walsh H, Wapniarski AE, Mohanty S, Lucas C, Klein J, Mao T, Oh J, Ring A, Spudich S, Ko AI, Kleinstein SH, Pak J, DeRisi JL, Iwasaki A, Pleasure SJ, Wilson MR, Farhadian SF. PMID: 33969321; PMCID: PMC8091032.
      View in: PubMed   Mentions: 86     Fields:    
    21. RETRACTED: Remission of Subacute Psychosis in a COVID-19 Patient With an Antineuronal Autoantibody After Treatment With Intravenous Immunoglobulin. Biol Psychiatry. 2021 08 15; 90(4):e23-e26. McAlpine LS, Lifland B, Check JR, Angarita GA, Ngo TT, Pleasure SJ, Wilson MR, Spudich SS, Farhadian SF, Bartley CM. PMID: 34001372; PMCID: PMC8041149.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    22. NMDA receptors control development of somatosensory callosal axonal projections. Elife. 2021 03 04; 10. Zhou J, Lin Y, Huynh T, Noguchi H, Bush JO, Pleasure SJ. PMID: 33661095; PMCID: PMC7959694.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    23. The Neocortical Progenitor Specification Program Is Established through Combined Modulation of SHH and FGF Signaling. J Neurosci. 2020 09 02; 40(36):6872-6887. Yabut OR, Ng HX, Yoon K, Arela JC, Ngo T, Pleasure SJ. PMID: 32737167; PMCID: PMC7470916.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    24. The Spectrum of Neurologic Disease in the Severe Acute Respiratory Syndrome Coronavirus 2 Pandemic Infection: Neurologists Move to the Frontlines. JAMA Neurol. 2020 06 01; 77(6):679-680. Pleasure SJ, Green AJ, Josephson SA. PMID: 32275291.
      View in: PubMed   Mentions: 94     Fields:    Translation:HumansCellsPHPublic Health
    25. Non-cell autonomous promotion of astrogenesis at late embryonic stages by constitutive YAP activation. Sci Rep. 2020 04 27; 10(1):7041. Han D, Kwon M, Lee SM, Pleasure SJ, Yoon K. PMID: 32341445; PMCID: PMC7184574.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    26. ANA Investigates: Pioneering Unbiased Diagnostics. Ann Neurol. 2020 03; 87(3):327-328. Richie M, Pleasure S, Hurley J, Goss A, Wilson M. PMID: 31953868.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    27. Kelch-like Protein 11 Antibodies in Seminoma-Associated Paraneoplastic Encephalitis. N Engl J Med. 2019 07 04; 381(1):47-54. Mandel-Brehm C, Dubey D, Kryzer TJ, O'Donovan BD, Tran B, Vazquez SE, Sample HA, Zorn KC, Khan LM, Bledsoe IO, McKeon A, Pleasure SJ, Lennon VA, DeRisi JL, Wilson MR, Pittock SJ. PMID: 31269365; PMCID: PMC6800027.
      View in: PubMed   Mentions: 78     Fields:    Translation:Humans
    28. Suppressor of Fused regulates the proliferation of postnatal neural stem and precursor cells via a Gli3-dependent mechanism. Biol Open. 2019 Jun 06; 8(6). Gomez HG, Noguchi H, Castillo JG, Aguilar D, Pleasure SJ, Yabut OR. PMID: 31142467; PMCID: PMC6602331.
      View in: PubMed   Mentions: 5     Fields:    
    29. Suppressor of fused controls perinatal expansion and quiescence of future dentate adult neural stem cells. Elife. 2019 04 11; 8. Noguchi H, Castillo JG, Nakashima K, Pleasure SJ. PMID: 30973324; PMCID: PMC6459675.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    30. Neural-Derived Extracellular Vesicles in Clinical Trials: Message in a Bottle. JAMA Neurol. 2019 04 01; 76(4):402-404. Dubal DB, Pleasure SJ. PMID: 30640380.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    31. Foxg1 Regulates the Postnatal Development of Cortical Interneurons. Cereb Cortex. 2019 04 01; 29(4):1547-1560. Shen W, Ba R, Su Y, Ni Y, Chen D, Xie W, Pleasure SJ, Zhao C. PMID: 29912324; PMCID: PMC6676970.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    32. Meningeal Bmps Regulate Cortical Layer Formation. Brain Plast. 2018 Dec 26; 4(2):169-183. Choe Y, Pleasure SJ. PMID: 30598868; PMCID: PMC6311355.
      View in: PubMed   Mentions: 6  
    33. FoxG1 Directly Represses Dentate Granule Cell Fate During Forebrain Development. Front Cell Neurosci. 2018; 12:452. Han X, Gu X, Zhang Q, Wang Q, Cheng Y, Pleasure SJ, Zhao C. PMID: 30532694; PMCID: PMC6265346.
      View in: PubMed   Mentions: 3  
    34. Ttyh1 regulates embryonic neural stem cell properties by enhancing the Notch signaling pathway. EMBO Rep. 2018 11; 19(11). Kim J, Han D, Byun SH, Kwon M, Cho JY, Pleasure SJ, Yoon K. PMID: 30177553; PMCID: PMC6216262.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    35. Sonic Hedgehog Signaling Rises to the Surface: Emerging Roles in Neocortical Development. Brain Plast. 2018 Aug 10; 3(2):119-128. Yabut OR, Pleasure SJ. PMID: 30151337; PMCID: PMC6091060.
      View in: PubMed   Mentions: 16  
    36. Impaired Organization of GABAergic Neurons Following Prenatal Hypoxia. Neuroscience. 2018 08 01; 384:300-313. Nisimov H, Orenbuch A, Pleasure SJ, Golan HM. PMID: 29874549.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    37. The Dorsal Wave of Neocortical Oligodendrogenesis Begins Embryonically and Requires Multiple Sources of Sonic Hedgehog. J Neurosci. 2018 06 06; 38(23):5237-5250. Winkler CC, Yabut OR, Fregoso SP, Gomez HG, Dwyer BE, Pleasure SJ, Franco SJ. PMID: 29739868; PMCID: PMC5990977.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    38. Focal cerebral β-amyloid angiopathy: A distinct clinicopathologic presentation. Neurol Clin Pract. 2017 Oct; 7(5):444-448. Karageorgiou E, Naasan G, Pleasure SJ, Alexandrescu S, Gelfand JM, Tammewar G, Miller BL, Rabinovici GD, Grinberg LT. PMID: 29620074; PMCID: PMC5874474.
      View in: PubMed   Mentions:
    39. Human Cytomegalovirus IE2 Protein Disturbs Brain Development by the Dysregulation of Neural Stem Cell Maintenance and the Polarization of Migrating Neurons. J Virol. 2017 09 01; 91(17). Han D, Byun SH, Kim J, Kwon M, Pleasure SJ, Ahn JH, Yoon K. PMID: 28615204; PMCID: PMC5553173.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    40. TRBP maintains mammalian embryonic neural stem cell properties by acting as a novel transcriptional coactivator of the Notch signaling pathway. Development. 2017 03 01; 144(5):778-783. Byun SH, Kim J, Han D, Kwon M, Cho JY, Ng HX, Pleasure SJ, Yoon K. PMID: 28174252; PMCID: PMC6514399.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    41. TAOK2 Kinase Mediates PSD95 Stability and Dendritic Spine Maturation through Septin7 Phosphorylation. Neuron. 2017 Jan 18; 93(2):379-393. Yadav S, Oses-Prieto JA, Peters CJ, Zhou J, Pleasure SJ, Burlingame AL, Jan LY, Jan YN. PMID: 28065648; PMCID: PMC5267388.
      View in: PubMed   Mentions: 67     Fields:    Translation:AnimalsCells
    42. The Crossroads of Neural Stem Cell Development and Tumorigenesis. Opera Med Physiol. 2016 Dec; 2(3-4):181-187. Yabut OR, Pleasure SJ. PMID: 28795171; PMCID: PMC5546789.
      View in: PubMed   Mentions: 6  
    43. Loss of Suppressor of Fused in Mid-Corticogenesis Leads to the Expansion of Intermediate Progenitors. J Dev Biol. 2016 Dec; 4(4). Yabut OR, Ng HX, Fernandez G, Yoon K, Kuhn J, Pleasure SJ. PMID: 28781964; PMCID: PMC5542684.
      View in: PubMed   Mentions: 5  
    44. Cerebrovascular defects in Foxc1 mutants correlate with aberrant WNT and VEGF-A pathways downstream of retinoic acid from the meninges. Dev Biol. 2016 Dec 01; 420(1):148-165. Mishra S, Choe Y, Pleasure SJ, Siegenthaler JA. PMID: 27671872; PMCID: PMC5124406.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    45. Diverse Functions of Retinoic Acid in Brain Vascular Development. J Neurosci. 2016 07 20; 36(29):7786-801. Bonney S, Harrison-Uy S, Mishra S, MacPherson AM, Choe Y, Li D, Jaminet SC, Fruttiger M, Pleasure SJ, Siegenthaler JA. PMID: 27445154; PMCID: PMC4951581.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    46. Cell Type-Specific Circuit Mapping Reveals the Presynaptic Connectivity of Developing Cortical Circuits. J Neurosci. 2016 Mar 16; 36(11):3378-90. Cocas LA, Fernandez G, Barch M, Doll J, Zamora Diaz I, Pleasure SJ. PMID: 26985044; PMCID: PMC4792945.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    47. Control of Adult Neurogenesis by Short-Range Morphogenic-Signaling Molecules. Cold Spring Harb Perspect Biol. 2015 Dec 04; 8(3):a018887. Choe Y, Pleasure SJ, Mira H. PMID: 26637286; PMCID: PMC4772099.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    48. Epithelial cells supply Sonic Hedgehog to the perinatal dentate gyrus via transport by platelets. Elife. 2015 Oct 12; 4. Choe Y, Huynh T, Pleasure SJ. PMID: 26457609; PMCID: PMC4600762.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    49. Suppressor of Fused Is Critical for Maintenance of Neuronal Progenitor Identity during Corticogenesis. Cell Rep. 2015 Sep 29; 12(12):2021-34. Yabut OR, Fernandez G, Huynh T, Yoon K, Pleasure SJ. PMID: 26387942; PMCID: PMC4591209.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    50. A Notch above Sonic Hedgehog. Dev Cell. 2015 May 26; 33(4):371-2. Yabut O, Pleasure SJ, Yoon K. PMID: 26017768.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    51. Migration of oligodendrocyte progenitor cells is controlled by transforming growth factor β family proteins during corticogenesis. J Neurosci. 2014 Nov 05; 34(45):14973-83. Choe Y, Huynh T, Pleasure SJ. PMID: 25378163; PMCID: PMC4220029.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    52. Heterogeneously expressed fezf2 patterns gradient Notch activity in balancing the quiescence, proliferation, and differentiation of adult neural stem cells. J Neurosci. 2014 Oct 15; 34(42):13911-23. Berberoglu MA, Dong Z, Li G, Zheng J, Trejo Martinez Ldel C, Peng J, Wagle M, Reichholf B, Petritsch C, Li H, Pleasure SJ, Guo S. PMID: 25319688; PMCID: PMC4198537.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    53. Loss of Wdfy3 in mice alters cerebral cortical neurogenesis reflecting aspects of the autism pathology. Nat Commun. 2014 Sep 08; 5:4692. Orosco LA, Ross AP, Cates SL, Scott SE, Wu D, Sohn J, Pleasure D, Pleasure SJ, Adamopoulos IE, Zarbalis KS. PMID: 25198012; PMCID: PMC4159772.
      View in: PubMed   Mentions: 43     Fields:    Translation:Animals
    54. Wrong place, wrong time: ectopic progenitors cause cortical heterotopias. Nat Neurosci. 2014 Jul; 17(7):894-5. Cocas L, Pleasure SJ. PMID: 24964156.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    55. The quintessence of quiescence. Neuron. 2014 May 07; 82(3):501-3. Yabut O, Pleasure SJ. PMID: 24811373.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    56. Neural crest-derived mesenchymal cells require Wnt signaling for their development and drive invagination of the telencephalic midline. PLoS One. 2014; 9(2):e86025. Choe Y, Zarbalis KS, Pleasure SJ. PMID: 24516524; PMCID: PMC3916303.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    57. The development of hippocampal cellular assemblies. Wiley Interdiscip Rev Dev Biol. 2014 Mar-Apr; 3(2):165-77. Li G, Pleasure SJ. PMID: 24719288.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    58. Cxcl12/Cxcr4 signaling controls the migration and process orientation of A9-A10 dopaminergic neurons. Development. 2013 Nov; 140(22):4554-64. Yang S, Edman LC, Sánchez-Alcañiz JA, Fritz N, Bonilla S, Hecht J, Uhlén P, Pleasure SJ, Villaescusa JC, Marín O, Arenas E. PMID: 24154522.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    59. Importance and hurdles to drug discovery for neurological disease. Ann Neurol. 2013 Sep; 74(3):441-6. Berger JR, Choi D, Kaminski HJ, Gordon MF, Hurko O, D'Cruz O, Pleasure SJ, Feldman EL. PMID: 25813523.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    60. A mutation in mouse Pak1ip1 causes orofacial clefting while human PAK1IP1 maps to 6p24 translocation breaking points associated with orofacial clefting. PLoS One. 2013; 8(7):e69333. Ross AP, Mansilla MA, Choe Y, Helminski S, Sturm R, Maute RL, May SR, Hozyasz KK, Wójcicki P, Mostowska A, Davidson B, Adamopoulos IE, Pleasure SJ, Murray JC, Zarbalis KS. PMID: 23935987; PMCID: PMC3723895.
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    141. Primitive neuroectodermal tumors (PNETs) of the CNS and PNS that express functional nerve growth factor receptors (NGFR) but fail to differentiate in response to NGF. Prog Clin Biol Res. 1991; 366:243-8. Reddy UR, Pleasure S, Baker D, Lee VM, Ross AH, Pleasure D. PMID: 1648743.
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    142. Introduction of nerve growth factor (NGF) receptors into a medulloblastoma cell line results in expression of high- and low-affinity NGF receptors but not NGF-mediated differentiation. Proc Natl Acad Sci U S A. 1990 Nov; 87(21):8496-500. Pleasure SJ, Reddy UR, Venkatakrishnan G, Roy AK, Chen J, Ross AH, Trojanowski JQ, Pleasure DE, Lee VM. PMID: 2172988; PMCID: PMC54983.
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    143. Human central nervous system primitive neuroectodermal tumor expressing nerve growth factor receptors: CHP707m. Ann Neurol. 1990 Aug; 28(2):136-45. Baker DL, Reddy UR, Pleasure S, Hardy M, Williams M, Tartaglione M, Biegel JA, Emanuel BS, Lo Presti P, Kreider B, et al. PMID: 2171417.
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    144. Site-specific phosphorylation of the middle molecular weight human neurofilament protein in transfected non-neuronal cells. J Neurosci. 1990 Jul; 10(7):2428-37. Pleasure SJ, Lee VM, Nelson DL. PMID: 1695947; PMCID: PMC6570384.
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    145. Lamprey neurofilaments combine in one subunit the features of each mammalian NF triplet protein but are highly phosphorylated only in large axons. J Neurosci. 1989 Feb; 9(2):698-709. Pleasure SJ, Selzer ME, Lee VM. PMID: 2493079; PMCID: PMC6569803.
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