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    Alan Wu, PhD

    TitleProfessor
    SchoolUCSF School of Medicine
    DepartmentLaboratory Medicine
    Address1001 Potrero Ave, SFGH 5
    San Francisco CA 94110
    Phone415-206-3540
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      Alan Wu has several areas of expertise. He is chief of the clinical chemistry and toxicology laboratories at San Francisco General Hospital. In this capacity, his clinical and research laboratory conducts testing for routine analytes in blood, urine and cerebral spinal fluid for electrolytes, metabolites, hormones, proteins, and biomarkers. His particular area of interest is in cardiac biomarkers for acute cardiac diseases (troponin, B-type natriuretic peptide, and novel biomarkers of ACS and heart failure).

      The toxicology laboratory has expertise and analytic equipment for quantitation of drugs and other small molecules in biological fluids. Using liquid chromatography (LC) /time-of-flight (TOF) mass spectrometry (MS), this laboratory is able to conduct unknown searches for chemicals in these samples based on high resolution molecular weight (2-5 ppm), enabling the assignment of precise molecular formula. The LC/TOF-MS is ideal for detection of unknown drugs, chemicals and specimens. Recently, this laboratory has expanded its services to include analysis of medications both pharmaceuticals and nutriceuticals (herbals) and street preparations for the presence of adulterants, contaminants, and supplements. Once tentatively identified, the toxicology laboratory has LC-tandem MS capability for quantitation in the pg/mL concentrations.

      Dr. Wu is also chief of the clinical pharmacogenomics laboratory and offers a clinical service and clinical research in pharmacogenomic for genomic targets such as cytochrome p450 2D6, 2C9, 2C19, vitamin K receptor complex, UDP glucuronsyltransferase, kif-6, and HLA-B*5710, 1502, and 5801. These targets for important for certain therapeutic drugs such as tamoxifen, codeine, antidepressants, warfarin, clopidogrel, irinotecan, statins, abacavir, carbamazepine, phenytoin, and allopurinol, respectively.


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      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Wu AH. High-sensitivity cardiac troponin testing for primary care: analytical assay considerations required before widespread implementation. Ann Transl Med. 2016 Jul; 4(13):251. PMID: 27501115.
        View in: PubMed
      2. Ruaño G, Seip R, Windemuth A, Wu AH, Thompson PD. Laboratory Medicine in the Clinical Decision Support for Treatment of Hypercholesterolemia: Pharmacogenetics of Statins. Clin Lab Med. 2016 Sep; 36(3):473-91. PMID: 27514463.
        View in: PubMed
      3. Vo KT, van Wijk XM, Lynch KL, Wu AH, Smollin CG. Counterfeit Norco Poisoning Outbreak - San Francisco Bay Area, California, March 25-April 5, 2016. MMWR Morb Mortal Wkly Rep. 2016; 65(16):420-3. PMID: 27123589.
        View in: PubMed
      4. Yang HS, Wu AH, Lynch KL. Development and Validation of a Novel LC-MS/MS Opioid Confirmation Assay: Evaluation of ß-glucuronidase Enzymes and Sample Cleanup Methods. J Anal Toxicol. 2016 Jun; 40(5):323-9. PMID: 27121711.
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      5. Sandoval Y, Herzog CA, Love SA, Cao J, Hu Y, Wu AH, Gilbertson D, Brunelli SM, Young A, Ler R, Apple FS. Prognostic Value of Serial Changes in High-Sensitivity Cardiac Troponin I and T over 3 Months Using Reference Change Values in Hemodialysis Patients. Clin Chem. 2016 Apr; 62(4):631-8. PMID: 26847217.
        View in: PubMed
      6. Wu AH, Christenson RH. The standards for reporting diagnostic accuracy studies 2015 update: is there a missing link to the triumvirate? Ann Transl Med. 2016 Feb; 4(3):44. PMID: 26904566.
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      7. Yang HS, Wu AH, Johnson-Davis KL, Lynch KL. Development and validation of an LC-MS/MS sulfonylurea assay for hypoglycemia cases in the emergency department. Clin Chim Acta. 2016 Feb 15; 454:130-4. PMID: 26790752.
        View in: PubMed
      8. Wu AH, Colby J. High-Resolution Mass Spectrometry for Untargeted Drug Screening. Methods Mol Biol. 2016; 1383:153-66. PMID: 26660184.
        View in: PubMed
      9. Oh SS, Galanter J, Thakur N, Pino-Yanes M, Barcelo NE, White MJ, de Bruin DM, Greenblatt RM, Bibbins-Domingo K, Wu AH, Borrell LN, Gunter C, Powe NR, Burchard EG. Diversity in Clinical and Biomedical Research: A Promise Yet to Be Fulfilled. PLoS Med. 2015 Dec; 12(12):e1001918. PMID: 26671224.
        View in: PubMed
      10. Putterman C, Wu A, Reiner-Benaim A, Batty DS, Sanz I, Oates J, Jakobi K, Petri M, Safer P, Gerwien R, Sorek R, Blumenstein Y, Cohen IR. SLE-key(®) rule-out serologic test for excluding the diagnosis of systemic lupus erythematosus: Developing the ImmunArray iCHIP(®). J Immunol Methods. 2016 Feb; 429:1-6. PMID: 26678162.
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      11. Thoren KL, Colby JM, Shugarts SB, Wu AH, Lynch KL. Comparison of Information-Dependent Acquisition on a Tandem Quadrupole TOF vs a Triple Quadrupole Linear Ion Trap Mass Spectrometer for Broad-Spectrum Drug Screening. Clin Chem. 2016 Jan; 62(1):170-8. PMID: 26453698.
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      12. Korley FK, Diaz-Arrastia R, Wu AH, Yue JK, Manley GT, Sair HI, Van Eyk J, Everett AD, Okonkwo DO, Valadka AB, Gordon WA, Maas AI, Mukherjee P, Yuh EL, Lingsma HF, Puccio AM, Schnyer DM. Circulating Brain-Derived Neurotrophic Factor Has Diagnostic and Prognostic Value in Traumatic Brain Injury. J Neurotrauma. 2016 Jan 15; 33(2):215-25. PMID: 26159676.
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      13. Secemsky EA, Scherzer R, Nitta E, Wu AH, Lange DC, Deeks SG, Martin JN, Snider J, Ganz P, Hsue PY. Novel Biomarkers of Cardiac Stress, Cardiovascular Dysfunction, and Outcomes in HIV-Infected Individuals. JACC Heart Fail. 2015 Aug; 3(8):591-9. PMID: 26164679; PMCID: PMC4529774 [Available on 08/01/16].
      14. Marston NA, Shah KS, Mueller C, Neath SX, Christenson RH, McCord J, Nowak RM, Daniels LB, Hollander JE, Apple F, Nagurney J, Schreiber D, deFilippi C, Diercks D, Limkakeng A, Anand IS, Wu AH, Jaffe AS, Peacock WF, Maisel AS. Serial sampling of copeptin levels improves diagnosis and risk stratification in patients presenting with chest pain: results from the CHOPIN trial. Emerg Med J. 2016 Jan; 33(1):23-9. PMID: 26105583.
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      15. Shah KS, Marston NA, Mueller C, Neath SX, Christenson RH, McCord J, Nowak RM, Vilke GM, Daniels LB, Hollander JE, Apple FS, Cannon CM, Nagurney J, Schreiber D, deFilippi C, Hogan CJ, Diercks DB, Limkakeng A, Anand IS, Wu AH, Clopton P, Jaffe AS, Peacock WF, Maisel AS. Midregional proadrenomedullin predicts mortality and major adverse cardiac events in patients presenting with chest pain: results from the CHOPIN trial. Acad Emerg Med. 2015 May; 22(5):554-63. PMID: 25908114.
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      16. Maxwell NM, Nevin RL, Stahl S, Block J, Shugarts S, Wu AH, Dominy S, Solano-Blanco MA, Kappelman-Culver S, Lee-Messer C, Maldonado J, Maxwell AJ. Prolonged neuropsychiatric effects following management of chloroquine intoxication with psychotropic polypharmacy. Clin Case Rep. 2015 Jun; 3(6):379-87. PMID: 26185633; PMCID: PMC4498847.
      17. Aw TC, van Wijk XM, Wu AH, Jaffe AS. Release of cardiac troponin using a high sensitivity assay after exercise: Type 2 acute myocardial infarction? Clin Chim Acta. 2015 Jun 15; 446:6-8. PMID: 25862921.
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      18. Colby JM, Wu AH, Lynch KL. Analysis of codeine positivity in urine of pain management patients. J Anal Toxicol. 2015 Jun; 39(5):407-10. PMID: 25840440.
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      19. Wu AH. Pharmacogenomic testing and response to warfarin. Lancet. 2015 Jun 6; 385(9984):2231-2. PMID: 25769360.
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      20. Wu AH. Analytical validation of novel cardiac biomarkers used in clinical trials. Am Heart J. 2015 May; 169(5):674-83. PMID: 25965715.
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      21. Wu AH, Hamilton R, Middleberg R, Kacinko S, Kearney T. Investigation of postmortem absorption and redistribution after the application of a fentanyl patch. J Forensic Sci. 2015 Mar; 60(2):532-5. PMID: 25676881.
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      22. Wu AH, Hale K. Predicting mortality after elective open-heart surgery using midregional-proadrenomedullin: is it time to scalp Acute Physiology and Chronic Health Evaluation IV? Crit Care Med. 2015 Feb; 43(2):494-5. PMID: 25599481.
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      23. Madasamy S, Chaudhuri V, Kong R, Alderete B, Adams CM, Knaak TD, Ruan W, Wu AH, Bigos M, Amento EP. Plaque array method and proteomics-based identification of biomarkers from Alzheimer's disease serum. Clin Chim Acta. 2015 Feb 20; 441:79-85. PMID: 25532947.
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      24. Hussan JR, Hunter PJ, Gladding PA, Greenberg N, Christie R, Wu A, Sorby H, Thomas JD. ICMA: an integrated cardiac modeling and analysis platform. Bioinformatics. 2015 Apr 15; 31(8):1331-3. PMID: 25481009; PMCID: PMC4393521.
      25. Wu AH, van Wijk XM. A new ultra-high sensitivity troponin I assay for chest pain patients with no evidence of troponin I using a conventional assay. Clin Biochem. 2015 Mar; 48(4-5):358-9. PMID: 25482854.
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      26. Lipinski MJ, Baker NC, Escárcega RO, Torguson R, Chen F, Aldous SJ, Christ M, Collinson PO, Goodacre SW, Mair J, Inoue K, Lotze U, Sebbane M, Cristol JP, Freund Y, Chenevier-Gobeaux C, Meune C, Eggers KM, Pracon R, Schreiber DH, Wu AH, Ordoñez-Llanos J, Jaffe AS, Twerenbold R, Mueller C, Waksman R. Comparison of conventional and high-sensitivity troponin in patients with chest pain: a collaborative meta-analysis. Am Heart J. 2015 Jan; 169(1):6-16.e6. PMID: 25497242.
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      27. Wu AH. Folate testing: time to retire your VCR. JAMA Intern Med. 2014 Oct; 174(10):1697-8. PMID: 25111459.
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      28. Storrow AB, Nowak RM, Diercks DB, Singer AJ, Wu AH, Kulstad E, LoVecchio F, Fromm C, Headden G, Potis T, Hogan CJ, Schrock JW, Zelinski DP, Greenberg MR, Christenson RH, Ritchie JC, Chamberlin JS, Bray KR, Rhodes DW, Trainor D, Southwick PC. Absolute and relative changes (delta) in troponin I for early diagnosis of myocardial infarction: Results of a prospective multicenter trial. Clin Biochem. 2015 Mar; 48(4-5):260-7. PMID: 25261587.
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      29. Wang BT, Colby JM, Wu AH, Lynch KL. Cross-reactivity of acetylfentanyl and risperidone with a fentanyl immunoassay. J Anal Toxicol. 2014 Nov-Dec; 38(9):672-5. PMID: 25248490.
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      30. Storrow AB, Christenson RH, Nowak RM, Diercks DB, Singer AJ, Wu AH, Kulstad E, LoVecchio F, Fromm C, Headden G, Potis T, Hogan CJ, Schrock JW, Zelinski DP, Greenberg MR, Ritchie JC, Chamberlin JS, Bray KR, Rhodes DW, Trainor D, Holmes D, Southwick PC. Diagnostic performance of cardiac Troponin I for early rule-in and rule-out of acute myocardial infarction: Results of a prospective multicenter trial. Clin Biochem. 2015 Mar; 48(4-5):254-9. PMID: 25195101.
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      31. Wu AH, Yang HS, Thoren K. Biological variation of the osmolality and the osmolal gap. Clin Biochem. 2014 Oct; 47(15):130-1. PMID: 25130958.
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      32. Apple FS, Hollander J, Wu AH, Jaffe AS. Improving the 510(k) FDA process for cardiac troponin assays: in search of common ground. Clin Chem. 2014 Oct; 60(10):1273-5. PMID: 25114274.
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      33. Mishra RK, Beatty AL, Jaganath R, Regan M, Wu AH, Whooley MA. B-type natriuretic peptides for the prediction of cardiovascular events in patients with stable coronary heart disease: the Heart and Soul Study. J Am Heart Assoc. 2014 Aug; 3(4). PMID: 25053234; PMCID: PMC4310375.
      34. Finlay JA, Wu AH. Biological variation of immunoglobulin heavy chain-light chain pairs in serum. Clin Chim Acta. 2014 Sep 25; 436:68-71. PMID: 24824555.
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      35. Wu AH. Biomarkers for cholesterol absorption and synthesis in hyperlipidemic patients: role for therapeutic selection. Clin Lab Med. 2014 Mar; 34(1):157-66, viii. PMID: 24507794.
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      36. Agarwal D, Pineda S, Michailidou K, Herranz J, Pita G, Moreno LT, Alonso MR, Dennis J, Wang Q, Bolla MK, Meyer KB, Menéndez-Rodríguez P, Hardisson D, Mendiola M, González-Neira A, Lindblom A, Margolin S, Swerdlow A, Ashworth A, Orr N, Jones M, Matsuo K, Ito H, Iwata H, Kondo N, Hartman M, Hui M, Lim WY, Iau PT, Sawyer E, Tomlinson I, Kerin M, Miller N, Kang D, Choi J-, Park SK, Noh D-, Hopper JL, Schmidt DF, Makalic E, Southey MC, Teo SH, Yip CH, Sivanandan K, Tay W-, Brauch H, Brüning T, Hamann U, Dunning AM, Shah M, Andrulis IL, Knight JA, Glendon G, Tchatchou S, Schmidt MK, Broeks A, Rosenberg EH, van't Veer LJ, Fasching PA, Renner SP, Ekici AB, Beckmann MW, Shen C-, Hsiung C-, Yu J-, Hou M-, Blot W, Cai Q, Wu AH, Tseng C-, Van Den Berg D, Stram DO, Cox A, Brock IW, Reed MW, Muir K, Lophatananon A, Stewart-Brown S, Siriwanarangsan P, Zheng W, Deming-Halverson S, Shrubsole MJ, Long J, Shu X-, Lu W, Gao Y-, Zhang B, Radice P, Peterlongo P, Manoukian S, Mariette F, Sangrajrang S, McKay J, Couch FJ, Toland AE, Yannoukakos D, Fletcher O, Johnson N, dos Santos Silva I, Peto J, Marme F, Burwinkel B, Guénel P, Truong T, Sanchez M, Mulot C, Bojesen SE, Nordestgaard BG, Flyer H, Brenner H, Dieffenbach AK, Arndt V, Stegmaier C, Mannermaa A, Kataja V, Kosma V-, Hartikainen JM, Lambrechts D, Yesilyurt BT, Floris G, Leunen K, Chang-Claude J, Rudolph A, Seibold P, Flesch-Janys D, Wang X, Olson JE, Vachon C, Purrington K, Giles GG, Severi G, Baglietto L, Haiman CA, Henderson BE, Schumacher F, Marchand LL, Simard J, Dumont M, Goldberg MS, Labréche F, Winqvist R, Pylkäs K, Jukkola-Vuorinen A, Grip M, Devilee P, Tollenaar RA, Seynaeve C, García-Closas M, Chanock SJ, Lissowska J, Figueroa JD, Czene K, Eriksson M, Humphreys K, Darabi H, Hooning MJ, Kriege M, Collée JM, Tilanus-Linthorst M, Li J, Jakubowska A, Lubinski J, Jaworska-Bieniek K, Durda K, Nevanlinna H, Muranen TA, Aittomäki K, Blomqvist C, Bogdanova N, Dörk T, Hall P, Chenevix-Trench G, Easton DF, Pharroah PD, Arias-Perez JI, Zamora P, Benítez J, Milne RL. FGF receptor genes and breast cancer susceptibility: results from the Breast Cancer Association Consortium. Br J Cancer. 2014 Feb 18; 110(4):1088-100. PMID: 24548884; PMCID: PMC3929867.
      37. Wu AH, Ruan W, Todd J, Lynch KL. Biological variation of ß-sitosterol, campesterol, and lathosterol as cholesterol absorption and synthesis biomarkers. Clin Chim Acta. 2014 Mar 20; 430:43-7. PMID: 24394292.
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      38. Neath SX, Jefferies JL, Berger JS, Wu AH, McConnell JP, Boone JL, McCullough PA, Jesse RL, Maisel AS. The current and future landscape of urinary thromboxane testing to evaluate atherothrombotic risk. Rev Cardiovasc Med. 2014; 15(2):119-30. PMID: 25051129.
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      39. Heath DD, Flat SW, Wu AH, Pruitt MA, Rock CL. Evaluation of tamoxifen and metabolites by LC-MS/MS and HPLC methods. Br J Biomed Sci. 2014; 71(1):33-9. PMID: 24693573; PMCID: PMC4337796.
      40. Wu AH. Biological and analytical variation of clinical biomarker testing: implications for biomarker-guided therapy. Curr Heart Fail Rep. 2013 Dec; 10(4):434-40. PMID: 24037380.
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      41. Roberts TK, Kraft CS, French D, Ji W, Wu AH, Tangpricha V, Fantz CR. Interpreting laboratory results in transgender patients on hormone therapy. Am J Med. 2014 Feb; 127(2):159-62. PMID: 24332725.
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      42. Wu AH, Kearney T. Lack of impairment due to confirmed codeine use prior to a motor vehicle accident: role of pharmacogenomics. J Forensic Leg Med. 2013 Nov; 20(8):1024-7. PMID: 24237812.
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      43. Ruddy KJ, Desantis SD, Gelman RS, Wu AH, Punglia RS, Mayer EL, Tolaney SM, Winer EP, Partridge AH, Burstein HJ. Personalized medicine in breast cancer: tamoxifen, endoxifen, and CYP2D6 in clinical practice. Breast Cancer Res Treat. 2013 Oct; 141(3):421-7. PMID: 24062210.
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      44. Province MA, Goetz MP, Brauch H, Flockhart DA, Hebert JM, Whaley R, Suman VJ, Schroth W, Winter S, Zembutsu H, Mushiroda T, Newman WG, Lee MT, Ambrosone CB, Beckmann MW, Choi JY, Dieudonné AS, Fasching PA, Ferraldeschi R, Gong L, Haschke-Becher E, Howell A, Jordan LB, Hamann U, Kiyotani K, Krippl P, Lambrechts D, Latif A, Langsenlehner U, Lorizio W, Neven P, Nguyen AT, Park BW, Purdie CA, Quinlan P, Renner W, Schmidt M, Schwab M, Shin JG, Stingl JC, Wegman P, Wingren S, Wu AH, Ziv E, Zirpoli G, Thompson AM, Jordan VC, Nakamura Y, Altman RB, Ames MM, Weinshilboum RM, Eichelbaum M, Ingle JN, Klein TE. CYP2D6 genotype and adjuvant tamoxifen: meta-analysis of heterogeneous study populations. Clin Pharmacol Ther. 2014 Feb; 95(2):216-27. PMID: 24060820; PMCID: PMC3904554.
      45. Wu AH. Genotype and phenotype concordance for pharmacogenetic tests through proficiency survey testing. Arch Pathol Lab Med. 2013 Sep; 137(9):1232-6. PMID: 23991737.
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      46. Lung DD, Scott BJ, Wu AH, Gerona RR. Prolonged ventilatory failure and flaccid quadriparesis after ingestion of poison hemlock. Muscle Nerve. 2013 Nov; 48(5):823-7. PMID: 23733387.
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      47. Kim Y, Smith A, Wu AH. C3435T polymorphism of MDR1 gene with warfarin resistance. Clin Chim Acta. 2013 Oct 21; 425:34-6. PMID: 23872171.
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      48. Lung DD, Wu AH, Gerona RR. Cardiotoxicity in a citalopram and olanzapine overdose. J Emerg Med. 2013 Oct; 45(4):554-8. PMID: 23871479.
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      49. Markova SM, De Marco T, Bendjilali N, Kobashigawa EA, Mefford J, Sodhi J, Le H, Zhang C, Halladay J, Rettie AE, Khojasteh C, McGlothlin D, Wu AH, Hsueh WC, Witte JS, Schwartz JB, Kroetz DL. Association of CYP2C9*2 with bosentan-induced liver injury. Clin Pharmacol Ther. 2013 Dec; 94(6):678-86. PMID: 23863877; PMCID: PMC3834031.
      50. Smith A, Wu AH, Lynch KL, Ko N, Grenache DG. Multi-wavelength spectrophotometric analysis for detection of xanthochromia in cerebrospinal fluid and accuracy for the diagnosis of subarachnoid hemorrhage. Clin Chim Acta. 2013 Sep 23; 424:231-6. PMID: 23800427.
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      51. Perera MA, Cavallari LH, Limdi NA, Gamazon ER, Konkashbaev A, Daneshjou R, Pluzhnikov A, Crawford DC, Wang J, Liu N, Tatonetti N, Bourgeois S, Takahashi H, Bradford Y, Burkley BM, Desnick RJ, Halperin JL, Khalifa SI, Langaee TY, Lubitz SA, Nutescu EA, Oetjens M, Shahin MH, Patel SR, Sagreiya H, Tector M, Weck KE, Rieder MJ, Scott SA, Wu AH, Burmester JK, Wadelius M, Deloukas P, Wagner MJ, Mushiroda T, Kubo M, Roden DM, Cox NJ, Altman RB, Klein TE, Nakamura Y, Johnson JA. Genetic variants associated with warfarin dose in African-American individuals: a genome-wide association study. Lancet. 2013 Aug 31; 382(9894):790-6. PMID: 23755828; PMCID: PMC3759580.
      52. Richards M, Di Somma S, Mueller C, Nowak R, Peacock WF, Ponikowski P, Mockel M, Hogan C, Wu AH, Clopton P, Filippatos GS, Anand I, Ng L, Daniels LB, Neath SX, Shah K, Christenson R, Hartmann O, Anker SD, Maisel A. Atrial fibrillation impairs the diagnostic performance of cardiac natriuretic peptides in dyspneic patients: results from the BACH Study (Biomarkers in ACute Heart Failure). JACC Heart Fail. 2013 Jun; 1(3):192-9. PMID: 24621869.
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      53. Maisel A, Mueller C, Neath SX, Christenson RH, Morgenthaler NG, McCord J, Nowak RM, Vilke G, Daniels LB, Hollander JE, Apple FS, Cannon C, Nagurney JT, Schreiber D, deFilippi C, Hogan C, Diercks DB, Stein JC, Headden G, Limkakeng AT, Anand I, Wu AH, Papassotiriou J, Hartmann O, Ebmeyer S, Clopton P, Jaffe AS, Peacock WF. Copeptin helps in the early detection of patients with acute myocardial infarction: primary results of the CHOPIN trial (Copeptin Helps in the early detection Of Patients with acute myocardial INfarction). J Am Coll Cardiol. 2013 Jul 9; 62(2):150-60. PMID: 23643595.
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      54. Wu AH, Christenson RH. Analytical and assay issues for use of cardiac troponin testing for risk stratification in primary care. Clin Biochem. 2013 Aug; 46(12):969-78. PMID: 23623945.
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      55. Wu AH, Bolger AF, Hollander JE. Growing pains with the use of high-sensitivity cardiac troponin assays. J Am Coll Cardiol. 2013 Oct 1; 62(14):1250-1. PMID: 23583241.
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      56. Wu AH, Wians F, Jaffe A. Biological variation of galectin-3 and soluble ST2 for chronic heart failure: implication on interpretation of test results. Am Heart J. 2013 Jun; 165(6):995-9. PMID: 23708172.
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      57. O'Conor K, Chang AM, Wu AH, Hollander JE. Myeloperoxidase and C-reactive protein in patients with cocaine-associated chest pain. Am J Emerg Med. 2013 Apr; 31(4):664-9. PMID: 23380098.
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      58. Petrie M, Lynch KL, Ekins S, Chang JS, Goetz RJ, Wu AH, Krasowski MD. Cross-reactivity studies and predictive modeling of "Bath Salts" and other amphetamine-type stimulants with amphetamine screening immunoassays. Clin Toxicol (Phila). 2013 Feb; 51(2):83-91. PMID: 23387345.
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      59. Petrie MS, Lynch KL, Wu AH, Steinhardt AA, Horowitz GL. Prescription compliance or illicit designer drug abuse? Clin Chem. 2012 Dec; 58(12):1631-4. PMID: 23193148.
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      60. Cantrell L, Suchard JR, Wu A, Gerona RR. Stability of active ingredients in long-expired prescription medications. Arch Intern Med. 2012 Nov 26; 172(21):1685-7. PMID: 23045150.
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      61. Thornton SL, Lo J, Clark RF, Wu AH, Gerona RR. Simultaneous detection of multiple designer drugs in serum, urine, and CSF in a patient with prolonged psychosis. Clin Toxicol (Phila). 2012 Dec; 50(10):1165-8. PMID: 23163617.
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      62. Wu AH, French D. Implementation of liquid chromatography/mass spectrometry into the clinical laboratory. Clin Chim Acta. 2013 May; 420:4-10. PMID: 23085380.
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      63. Möckel M, Searle J, Hartmann O, Anker SD, Peacock WF, Wu AH, Maisel A, Slagman A, Vollert JO, Papassotiriou J, Anand I, Christenson R, Daniels LB, Filippatos GS, Hogan C, Morgenthaler N, Mueller C, Neath SX, Ng L, Nowak R, Richards M, Di Somma S, Ponikowski P. Mid-regional pro-adrenomedullin improves disposition strategies for patients with acute dyspnoea: results from the BACH trial. Emerg Med J. 2013 Aug; 30(8):633-7. PMID: 22962091.
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      64. Dempsey DA, Meyers MJ, Oh SS, Nguyen EA, Fuentes-Afflick E, Wu AH, Jacob P, Benowitz NL. Determination of tobacco smoke exposure by plasma cotinine levels in infants and children attending urban public hospital clinics. Arch Pediatr Adolesc Med. 2012 Sep 1; 166(9):851-6. PMID: 22566513; PMCID: PMC3997061.
      65. Gerona RR, Wu AH. Bath salts. Clin Lab Med. 2012 Sep; 32(3):415-27. PMID: 22939300.
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      66. Wu AH, Gerona R, Armenian P, French D, Petrie M, Lynch KL. Role of liquid chromatography-high-resolution mass spectrometry (LC-HR/MS) in clinical toxicology. Clin Toxicol (Phila). 2012 Sep; 50(8):733-42. PMID: 22888997.
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      67. Schreiber DH, Agbo C, Wu AH. Short-term (90 min) diagnostic performance for acute non-ST segment elevation myocardial infarction and 30-day prognostic evaluation of a novel third-generation high sensitivity troponin I assay. Clin Biochem. 2012 Nov; 45(16-17):1295-301. PMID: 22705845.
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      68. Wu AH, Lorizio W, Tchu S, Lynch K, Gerona R, Ji W, Ruan W, Ruddy KJ, Desantis SD, Burstein HJ, Ziv E. Estimation of tamoxifen metabolite concentrations in the blood of breast cancer patients through CYP2D6 genotype activity score. Breast Cancer Res Treat. 2012 Jun; 133(2):677-83. PMID: 22294487.
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      69. Armenian P, Mamantov TM, Tsutaoka BT, Gerona RR, Silman EF, Wu AH, Olson KR. Multiple MDMA (Ecstasy) overdoses at a rave event: a case series. J Intensive Care Med. 2013 Jul-Aug; 28(4):252-8. PMID: 22640978.
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      70. Wu AH, Tabas J, Stein J, Potocki M, Mueller C, McCord J, Richards M, Hartmann O, Nowak R, Peacock WF, Ponikowski P, Moeckel M, Hogan C, Filippatos GS, Di Somma S, Anand I, Ng L, Neath SX, Christenson R, Morgenthaler NG, Anker SD, Maisel AS. The effect of diabetes on the diagnostic and prognostic performance of mid-region pro-atrial natriuretic peptide and mid-region pro-adrenomedullin in patients with acute dyspnea. Biomarkers. 2012 Sep; 17(6):490-7. PMID: 22616939.
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      71. Rifai N, Annesley TM, Berg JP, Brugnara C, Delvin E, Lamb EJ, Ness PM, Plebani M, Wick MR, Wu A, Delanghe J. An appeal to medical journal editors: the need for a full description of laboratory methods and specimen handling in clinical study reports. Am J Hematol. 2012 Apr; 87(4):347-8. PMID: 22410758.
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      248. Wu AH, Bellantoni NF. Stability of cholesterol gall stones after 165 years of burial. J Forensic Sci. 2003 May; 48(3):633-4. PMID: 12762537.
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      256. Phillips JE, Bogema S, Fu P, Furmaga W, Wu AH, Zic V, Hammett-Stabler C. Signify ER Drug Screen Test evaluation: comparison to Triage Drug of Abuse Panel plus tricyclic antidepressants. Clin Chim Acta. 2003 Feb; 328(1-2):31-8. PMID: 12559596.
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      259. DeRoche ME, Ingardia CJ, Guerette PJ, Wu AH, LaSala CA, Mandavilli SR. The use of lamellar body counts to predict fetal lung maturity in pregnancies complicated by diabetes mellitus. Am J Obstet Gynecol. 2002 Oct; 187(4):908-12. PMID: 12388975.
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      337. Tsongalis GJ, Anamani DE, Wu AH. Identification of urine specimen donors by the PM+DQA1 amplification and typing kit. J Forensic Sci. 1996 Nov; 41(6):1031-4. PMID: 8914292.
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      338. Abbas SA, Glazier JJ, Wu AH, Dupont C, Green SF, Pearsall LA, Waters DD, McKay RG. Factors associated with the release of cardiac troponin T following percutaneous transluminal coronary angioplasty. Clin Cardiol. 1996 Oct; 19(10):782-6. PMID: 8896910.
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      339. Morris S, Wu AH, Heller GV. The role of cardiac imaging and biochemical markers in patients with acute chest pain. Curr Opin Cardiol. 1996 Jul; 11(4):386-93. PMID: 8879949.
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      340. Wu AH, Feng YJ, Contois JH, Pervaiz S. Comparison of myoglobin, creatine kinase-MB, and cardiac troponin I for diagnosis of acute myocardial infarction. Ann Clin Lab Sci. 1996 Jul-Aug; 26(4):291-300. PMID: 8800429.
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      341. Nicolau DP, Feng YJ, Wu AH, Bernstein SP, Nightingale CH. Swine model of continuous arteriovenous hemofiltration. Lab Anim Sci. 1996 Jun; 46(3):355-7. PMID: 8799948.
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      342. Nicolau DP, Wu AH, Finocchiaro S, Udeh E, Chow MS, Quintiliani R, Nightingale CH. Once-daily aminoglycoside dosing: impact on requests and costs for therapeutic drug monitoring. Ther Drug Monit. 1996 Jun; 18(3):263-6. PMID: 8738765.
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      343. Wu AH, Feng YJ, Contois JH, Azar R, Waters D. Prognostic value of cardiac troponin I in patients with chest pain. Clin Chem. 1996 Apr; 42(4):651-2. PMID: 8605692.
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      344. Apple FS, Wu AH, Valdes R. Serum cardiac troponin T concentrations in hospitalized patients without acute myocardial infarction. Scand J Clin Lab Invest. 1996 Feb; 56(1):63-8. PMID: 8850174.
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      345. Cao G, Verdon CP, Wu AH, Wang H, Prior RL. Automated assay of oxygen radical absorbance capacity with the COBAS FARA II. Clin Chem. 1995 Dec; 41(12 Pt 1):1738-44. PMID: 7497614.
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      346. Wu AH, Abbas SA, Green S, Pearsall L, Dhakam S, Azar R, Onoroski M, Senaie A, Mckay RG, Waters D. Prognostic value of cardiac troponin T in unstable angina pectoris. Am J Cardiol. 1995 Nov 1; 76(12):970-2. PMID: 7484843.
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      347. Sulkowski HA, Wu AH, McCarter YS. In-vitro production of ethanol in urine by fermentation. J Forensic Sci. 1995 Nov; 40(6):990-3. PMID: 8522931.
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      348. Wu AH, Whittemore AS, Kolonel LN, John EM, Gallagher RP, West DW, Hankin J, Teh CZ, Dreon DM, Paffenbarger RS. Serum androgens and sex hormone-binding globulins in relation to lifestyle factors in older African-American, white, and Asian men in the United States and Canada. Cancer Epidemiol Biomarkers Prev. 1995 Oct-Nov; 4(7):735-41. PMID: 8672990.
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      349. Wu AH, Lane PL. Metaanalysis in clinical chemistry: validation of cardiac troponin T as a marker for ischemic heart diseases. Clin Chem. 1995 Aug; 41(8 Pt 2):1228-33. PMID: 7628112.
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      350. Wu AH. Mechanism of interferences for gas chromatography/mass spectrometry analysis of urine for drugs of abuse. Ann Clin Lab Sci. 1995 Jul-Aug; 25(4):319-29. PMID: 7668815.
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      351. Wu AH, Forte E, Casella G, Sun K, Hemphill G, Foery R, Schanzenbach H. CEDIA for screening drugs of abuse in urine and the effect of adulterants. J Forensic Sci. 1995 Jul; 40(4):614-8. PMID: 7595298.
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      352. Wu AH, Fontham ET, Reynolds P, Greenberg RS, Buffler P, Liff J, Boyd P, Henderson BE, Correa P. Previous lung disease and risk of lung cancer among lifetime nonsmoking women in the United States. Am J Epidemiol. 1995 Jun 1; 141(11):1023-32. PMID: 7771438.
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      353. John EM, Whittemore AS, Wu AH, Kolonel LN, Hislop TG, Howe GR, West DW, Hankin J, Dreon DM, Teh CZ. Vasectomy and prostate cancer: results from a multiethnic case-control study. J Natl Cancer Inst. 1995 May 3; 87(9):662-9. PMID: 7538594.
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      354. Whittemore AS, Wu AH, Kolonel LN, John EM, Gallagher RP, Howe GR, West DW, Teh CZ, Stamey T. Family history and prostate cancer risk in black, white, and Asian men in the United States and Canada. Am J Epidemiol. 1995 Apr 15; 141(8):732-40. PMID: 7535977.
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      355. Laios ID, Caruk R, Wu AH. Myoglobin clearance as an early indicator for rhabdomyolysis-induced acute renal failure. Ann Clin Lab Sci. 1995 Mar-Apr; 25(2):179-84. PMID: 7785966.
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      356. Makowski GS, Richter JJ, Moore RE, Eisma R, Ostheimer D, Onoroski M, Wu AH. An enzyme-linked immunosorbent assay for urinary screening of fentanyl citrate abuse. Ann Clin Lab Sci. 1995 Mar-Apr; 25(2):169-78. PMID: 7785965.
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      357. Wu AH, Kelly T, McKay C, Ostheimer D, Forte E, Hill D. Definitive identification of an exceptionally high methanol concentration in an intoxication of a surviving infant: methanol metabolism by first-order elimination kinetics. J Forensic Sci. 1995 Mar; 40(2):315-20. PMID: 7602299.
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      358. Wu AH, Valdes R, Apple FS, Gornet T, Stone MA, Mayfield-Stokes S, Ingersoll-Stroubos AM, Wiler B. Cardiac troponin-T immunoassay for diagnosis of acute myocardial infarction. Clin Chem. 1994 Jun; 40(6):900-7. PMID: 8087984.
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      359. Wu AH, Laios I, Green S, Gornet TG, Wong SS, Parmley L, Tonnesen AS, Plaisier B, Orlando R. Immunoassays for serum and urine myoglobin: myoglobin clearance assessed as a risk factor for acute renal failure. Clin Chem. 1994 May; 40(5):796-802. PMID: 8174254.
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      360. Wu AH, Ostheimer D, Cremese M, Forte E, Hill D. Characterization of drug interferences caused by coelution of substances in gas chromatography/mass spectrometry confirmation of targeted drugs in full-scan and selected-ion monitoring modes. Clin Chem. 1994 Feb; 40(2):216-20. PMID: 8313597.
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      361. Liu N, Wu AH, Wong SS. Improved quantitative Apt test for detecting fetal hemoglobin in bloody stools of newborns. Clin Chem. 1993 Nov; 39(11 Pt 1):2326-9. PMID: 7693375.
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      362. Friedman DL, Kesterson R, Puleo P, Wu AH, Perryman MB. Recombinant creatine kinase proteins and proposed standards for creatine kinase isoenzyme and subform assays. Clin Chem. 1993 Aug; 39(8):1598-601. PMID: 8353943.
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      363. Wu AH, Wong SS, Johnson KG, Callies J, Shu DX, Dunn WE, Wong SH. Evaluation of the triage system for emergency drugs-of-abuse testing in urine. J Anal Toxicol. 1993 Jul-Aug; 17(4):241-5. PMID: 8371556.
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      364. Wu AH, Liu N, Cho YJ, Johnson KG, Wong SS. Extraction and simultaneous elution and derivatization of 11-nor-9-carboxy-delta 9-tetrahydrocannabinol using Toxi-Lab SPEC prior to GC/MS analysis of urine. J Anal Toxicol. 1993 Jul-Aug; 17(4):215-7. PMID: 8396694.
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      365. Wu AH, Taylor GR, Graham GA, McKinley BA. The clinical chemistry and immunology of long-duration space missions. Clin Chem. 1993 Jan; 39(1):22-36. PMID: 8419055.
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      366. Wu AH, Gornet TG, Schenkel O, Smith-Cronin L, Graham GA, Tonnesen AS, McKinley BA. Preliminary evaluation of an experimental clinical chemistry analyzer developed for space medicine. Clin Chem. 1993 Jan; 39(1):37-44. PMID: 8419056.
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      367. Onigbinde TA, Wu AH, Wu YS, Simmons MJ, Wong SS. Mechanism of differential inhibition of lactate dehydrogenase isoenzymes in the BMC LD-1 assay. Clin Biochem. 1992 Dec; 25(6):425-9. PMID: 1477966.
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      368. Wu AH, Perryman MB. Clinical applications of muscle enzymes and proteins. Curr Opin Rheumatol. 1992 Dec; 4(6):815-20. PMID: 1457275.
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      369. Wu AH, Wang XM, Gornet TG, Ordóñez-Llanos J. Creatine kinase MB isoforms in patients with skeletal muscle injury: ramifications for early detection of acute myocardial infarction. Clin Chem. 1992 Dec; 38(12):2396-400. PMID: 1458574.
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      370. Wu AH, Johnson KG, Wong SS. Impact of revised NIDA guidelines for methamphetamine testing in urine. Clin Chem. 1992 Nov; 38(11):2352-3. PMID: 1424147.
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      371. Wu AH, Onigbinde TA, Wong SS, Johnson KG. Evaluation of full-scanning GC/ion trap MS analysis of NIDA drugs-of-abuse urine testing in urine. J Anal Toxicol. 1992 May-Jun; 16(3):202-6. PMID: 1522718.
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      372. Wu AH, Onigbinde TA, Wong SS, Johnson KG. Identification of methamphetamines and over-the-counter sympathometic amines by full-scan GC-ion trap MS with electron impact and chemical ionization. J Anal Toxicol. 1992 Mar-Apr; 16(2):137-41. PMID: 1501464.
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      373. Wu AH, Onigbinde TA, Johnson KG, Wimbish GH. Alcohol-specific cocaine metabolites in serum and urine of hospitalized patients. J Anal Toxicol. 1992 Mar-Apr; 16(2):132-6. PMID: 1501463.
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      374. Rosano TG, Ambrose RT, Wu AH, Swift TA, Yadegari P. Candidate reference method for determining creatinine in serum: method development and interlaboratory validation. Clin Chem. 1990 Nov; 36(11):1951-5. PMID: 2242575.
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      375. Onigbinde TA, Wu AH, Johnson M, Wu YS, Collinsworth WL, Simmons MJ. Clinical evaluation of an automated chemical inhibition assay for lactate dehydrogenase isoenzyme 1. Clin Chem. 1990 Oct; 36(10):1819-22. PMID: 2208662.
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      376. Khalil SN, Florence FB, Van den Nieuwenhuyzen MC, Wu AH, Stanley TH. Rectal methohexital: concentration and length of the rectal catheters. Anesth Analg. 1990 Jun; 70(6):645-9. PMID: 2344059.
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      377. Wu AH, Gornet TG, Harker CC, Chen HL. Role of rapid immunoassays for urgent ("stat") determinations of creatine kinase isoenyme MB. Clin Chem. 1989 Aug; 35(8):1752-6. PMID: 2758646.
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      378. Wu AH. Creatine kinase isoforms in ischemic heart disease. Clin Chem. 1989 Jan; 35(1):7-13. PMID: 2642764.
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      379. Jone CM, Wu AH. An unusual case of toluene-induced metabolic acidosis. Clin Chem. 1988 Dec; 34(12):2596-9. PMID: 3197320.
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      380. LeMaistre A, Bracey A, Katz A, Wu AH. Role of qualitative choriogonadotropin assays in diagnosis of ectopic pregnancy. Clin Chem. 1987 Oct; 33(10):1908-10. PMID: 2959401.
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      381. Wu AH, Wong SS, Waldron C, Chan DW. Automated quantification of choriogonadotropin: analytical correlation between serum and urine with creatinine correction. Clin Chem. 1987 Aug; 33(8):1424-6. PMID: 3038377.
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      382. Wong SS, Earl R, Wu AH. Simultaneous presence of IgA- and IgG-CK-BB in a patient without myocardial infarction. Clin Chim Acta. 1987 Jun 30; 166(1):99-100. PMID: 3608205.
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      383. Wong SS, Wu AH, Fritsche HA. Reassessment of creatine kinase BB as a marker for cancer of the prostate, breast, and lung. Clin Chem. 1987 Jun; 33(6):809-11. PMID: 3594821.
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      384. Wu AH, Gornet TG, Wu VH, Brockie RE, Nishikawa A. Early diagnosis of acute myocardial infarction by rapid analysis of creatine kinase isoenzyme-3 (CK-MM) sub-types. Clin Chem. 1987 Mar; 33(3):358-62. PMID: 3815799.
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      385. Spain MA, Wu AH. Bilirubin interference with determination of uric acid, cholesterol, and triglycerides in commercial peroxidase-coupled assays, and the effect of ferrocyanide. Clin Chem. 1986 Mar; 32(3):518-21. PMID: 3948397.
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      386. Wu AH, Gornet TG. Measurement of creatine kinase MM sub-type by anion-exchange liquid chromatography. Clin Chem. 1985 Nov; 31(11):1841-5. PMID: 3931938.
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      387. Wu AH, Gornet TG, Bretaudiere JP, Panfili PR. Comparison of enzyme immunoassay and immunoprecipitation for creatine kinase MB in diagnosis of acute myocardial infarction. Clin Chem. 1985 Mar; 31(3):470-4. PMID: 3882278.
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      388. Wu AH, Gornet TG. Preparation of urine samples for liquid-chromatographic determination of catecholamines: bonded-phase phenylboronic acid, cation-exchange resin, and alumina adsorbents compared. Clin Chem. 1985 Feb; 31(2):298-302. PMID: 3967369.
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      389. Wu AH, Strocchia C, Gornet TG, Edwards J. An inexpensive lyophilized quality-control material for cardiac isoenzymes. Clin Chem. 1984 Oct; 30(10):1718-9. PMID: 6478610.
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      390. Wu AH, Parker OS, Ford L. Hyperviscosity caused by hyaluronic acid in serum in a case of Wilms' tumor. Clin Chem. 1984 Jun; 30(6):914-6. PMID: 6327120.
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      391. Wu AH, Herson VC, Bowers GN. Macro creatine kinase types 1 and 2: clinical significance in neonates and children as compared with adults. Clin Chem. 1983 Jan; 29(1):201-4. PMID: 6848262.
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      392. WU AH, Stout R, McComb RB. Falsely high serum creatinine concentration associated with severe methanol intoxication. Clin Chem. 1983 Jan; 29(1):205-8. PMID: 6848263.
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      393. Wu AH, Bowers GN. Evaluation and comparison of immunoinhibition and immunoprecipitation methods for differentiating MB and BB from macro forms of creatine kinase isoenzymes in patients and healthy individuals. Clin Chem. 1982 Oct; 28(10):2017-21. PMID: 7127730.
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      394. Wu AH, Ohneck J, Klaus E, McComb RB. A washer-dryer system for cuvette rotors used in the Cobas-Bio Centrifugal Analyzer. Clin Chem. 1982 Oct; 28(10):2188-9. PMID: 7127762.
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      395. Wu AH, Rotunno T, Malmstadt HV. Microcomputer controlled titration for determination of protein nitrogen in feeds and wheat. J Assoc Off Anal Chem. 1979 Sep; 62(5):969-75. PMID: 393695.
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