Bruce Conklin, MD
|School||UCSF School of Medicine|
|Address||1650 Owens St, SF 94158|
We use induced pluripotent stem (iPS) cells to model human disease. Our major focus is on genes that cause “sudden death” due to abnormal heart rhythm, and heart failure from cardiomyopathy. We use iPS cells from patients and also engineering iPS cells to have specific mutations. Engineering iPS cells allows direct comparison of cells with the exact same (isogenic) background. Recent genetic studies provide gene variant associations that are largely untested. comparing iPS cells with discrete mutations in an isogenic background provide an experimental system to directly test these genetic associations. Personalized medicine can benefit from experimental testing of gene variants to prove (or disprove) hypothetical genetic associations.
iPS cells, Cardiomyopathy, Genetics, Genome Engineering
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