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    Kristine Yaffe, MD

    TitleProfessor of Psychiatry, Neurology and Epidemiology
    SchoolUCSF School of Medicine
    DepartmentPsychiatry
    Address4150 Clement St
    San Francisco CA 94121
    Phone415-221-4810x3985
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      Other Positions
      TitleRoy and Marie Scola Endowed Chair

      TitleVice Chair of Research in Psychiatry


      Collapse Biography 
      Collapse Education and Training
      Yale University BSBiology-Psychology
      University of Pennyslvania M.D.School of Medicine
      University of California, San FranciscoResidency Neurology and Psychiatry

      Collapse Overview 
      Collapse Overview
      Kristine Yaffe, MD, is a Professor of Psychiatry, Neurology and Epidemiology, the Roy and Marie Scola Endowed Chair and Vice Chair of Research in Psychiatry at UCSF. Dr. Yaffe is dually trained in neurology and psychiatry and completed postdoctoral training in epidemiology and geriatric psychiatry, all at UCSF. In addition to her positions at UCSF, Dr. Yaffe is the Chief of Geriatric Psychiatry and the Director of the Memory Disorders Clinic at the San Francisco Veteran’s Affairs Medical Center. In her research, clinical work, and mentoring, she has worked towards improving the care of patients with cognitive disorders and other geriatric neuropsychiatric conditions.

      Dr. Yaffe's research has focused on the predictors and outcomes of cognitive decline and dementia in older adults. She is particularly interested in identifying novel risk factors for cognitive impairment that may lead to strategies to prevent cognitive decline. Dr. Yaffe is the principal investigator of 7 NIH grants as well as several other grants, and she has published over 350 peer-reviewed articles (H-index=97) in numerous prestigious journals including the Lancet, BMJ, JAMA, and NEJM. Dr. Yaffe also edited a book published by Oxford Press, “Chronic Medical Disease and Cognitive Aging: Toward a Healthy Body and Brain.” In 2014, she was recognized as one of Thomas Reuters World’s Most Influential Scientific Minds and honored by the American Association for Geriatric Psychiatry with the Distinguished Scientist Award.


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      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Rodriguez RD, Suemoto CK, Molina M, Nascimento CF, Leite RE, de Lucena Ferretti-Rebustini RE, Farfel JM, Heinsen H, Nitrini R, Ueda K, Pasqualucci CA, Jacob-Filho W, Yaffe K, Grinberg LT. Argyrophilic Grain Disease: Demographics, Clinical, and Neuropathological Features From a Large Autopsy Study. J Neuropathol Exp Neurol. 2016 Jul; 75(7):628-35. PMID: 27283329.
        View in: PubMed
      2. Nettiksimmons J, Tranah G, Evans DS, Yokoyama JS, Yaffe K. Gene-based aggregate SNP associations between candidate AD genes and cognitive decline. Age (Dordr). 2016 Apr; 38(2):41. PMID: 27005436.
        View in: PubMed
      3. Kaup AR, Byers AL, Falvey C, Simonsick EM, Satterfield S, Ayonayon HN, Smagula SF, Rubin SM, Yaffe K. Trajectories of Depressive Symptoms in Older Adults and Risk of Dementia. JAMA Psychiatry. 2016 Mar 16. PMID: 26982217.
        View in: PubMed
      4. Kurella Tamura M, Yaffe K, Hsu CY, Yang J, Sozio S, Fischer M, Chen J, Ojo A, DeLuca J, Xie D, Vittinghoff E, Go AS. Cognitive Impairment and Progression of CKD. Am J Kidney Dis. 2016 Mar 10. PMID: 26972681.
        View in: PubMed
      5. Albanese E, Matthews KA, Zhang J, Jacobs DR, Whitmer RA, Wadley VG, Yaffe K, Sidney S, Launer LJ. Hostile attitudes and effortful coping in young adulthood predict cognition 25 years later. Neurology. 2016 Mar 29; 86(13):1227-34. PMID: 26935891.
        View in: PubMed
      6. Goveas JS, Rapp SR, Hogan PE, Driscoll I, Tindle HA, Smith JC, Kesler SR, Zaslavsky O, Rossom RC, Ockene JK, Yaffe K, Manson JE, Resnick SM, Espeland MA. Predictors of Optimal Cognitive Aging in 80+ Women: The Women's Health Initiative Memory Study. J Gerontol A Biol Sci Med Sci. 2016 Mar; 71 Suppl 1:S62-71. PMID: 26858326.
        View in: PubMed
      7. Auer R, Vittinghoff E, Yaffe K, Künzi A, Kertesz SG, Levine DA, Albanese E, Whitmer RA, Jacobs DR, Sidney S, Glymour MM, Pletcher MJ. Association Between Lifetime Marijuana Use and Cognitive Function in Middle Age: The Coronary Artery Risk Development in Young Adults (CARDIA) Study. JAMA Intern Med. 2016 Mar 1; 176(3):352-61. PMID: 26831916.
        View in: PubMed
      8. Contrera KJ, Betz J, Deal JA, Choi JS, Ayonayon HN, Harris T, Helzner E, Martin KR, Mehta K, Pratt S, Rubin SM, Satterfield S, Yaffe K, Garcia M, Simonsick EM, Lin FR. Association of Hearing Impairment and Emotional Vitality in Older Adults. J Gerontol B Psychol Sci Soc Sci. 2016 May; 71(3):400-4. PMID: 26883806.
        View in: PubMed
      9. Diem SJ, Blackwell TL, Stone KL, Yaffe K, Tranah G, Cauley JA, Ancoli-Israel S, Redline S, Spira AP, Hillier TA, Ensrud KE. Measures of Sleep-Wake Patterns and Risk of Mild Cognitive Impairment or Dementia in Older Women. Am J Geriatr Psychiatry. 2016 Mar; 24(3):248-58. PMID: 26964485.
        View in: PubMed
      10. Yaffe K. Moving Beyond Dualism to Advance Geriatric Neuropsychiatry. Am J Geriatr Psychiatry. 2016 May; 24(5):339-41. PMID: 27066734.
        View in: PubMed
      11. Kurella Tamura M, Vittinghoff E, Yang J, Go AS, Seliger SL, Kusek JW, Lash J, Cohen DL, Simon J, Batuman V, Ordonez J, Makos G, Yaffe K. Anemia and risk for cognitive decline in chronic kidney disease. BMC Nephrol. 2016; 17(1):13. PMID: 26823182.
        View in: PubMed
      12. Stone KL, Blackwell TL, Ancoli-Israel S, Barrett-Connor E, Bauer DC, Cauley JA, Ensrud KE, Hoffman AR, Mehra R, Stefanick ML, Varosy PD, Yaffe K, Redline S. Sleep Disordered Breathing and Risk of Stroke in Older Community-dwelling Men. Sleep. 2016 Jan 15. PMID: 26943468.
        View in: PubMed
      13. Byers AL, Lai AX, Arean P, Nelson JC, Yaffe K. Mental Health Service Use Across the Life Course Among Adults With Psychiatric Disorders and Prior Suicidal Behavior. Psychiatr Serv. 2016 Apr 1; 67(4):452-5. PMID: 26766753.
        View in: PubMed
      14. Yano Y, Ning H, Reis JP, Lewis CE, Launer LJ, Bryan RN, Yaffe K, Sidney S, Albanese E, Greenland P, Lloyd-Jones D, Liu K. Blood Pressure Reactivity to Psychological Stress in Young Adults and Cognition in Midlife: The Coronary Artery Risk Development in Young Adults (CARDIA) Study. J Am Heart Assoc. 2016; 5(1). PMID: 26764414.
        View in: PubMed
      15. Rosario BL, Rosso AL, Aizenstein HJ, Harris T, Newman AB, Satterfield S, Studenski SA, Yaffe K, Rosano C. Cerebral White Matter and Slow Gait: Contribution of Hyperintensities and Normal-appearing Parenchyma. J Gerontol A Biol Sci Med Sci. 2016 Jul; 71(7):968-73. PMID: 26755683.
        View in: PubMed
      16. Hoang TD, Reis J, Zhu N, Jacobs DR, Launer LJ, Whitmer RA, Sidney S, Yaffe K. Effect of Early Adult Patterns of Physical Activity and Television Viewing on Midlife Cognitive Function. JAMA Psychiatry. 2016 Jan 1; 73(1):73-9. PMID: 26629780.
        View in: PubMed
      17. Ensrud KE, Lui LY, Paudel ML, Schousboe JT, Kats AM, Cauley JA, McCulloch CE, Yaffe K, Cawthon PM, Hillier TA, Taylor BC. Effects of Mobility and Cognition on Risk of Mortality in Women in Late Life: A Prospective Study. J Gerontol A Biol Sci Med Sci. 2016 Jun; 71(6):759-65. PMID: 26714566.
        View in: PubMed
      18. Padula CB, Weitlauf JC, Rosen AC, Reiber G, Cochrane BB, Naughton MJ, Li W, Rissling M, Yaffe K, Hunt JR, Stefanick ML, Goldstein MK, Espeland MA. Longitudinal Cognitive Trajectories of Women Veterans from the Women's Health Initiative Memory Study. Gerontologist. 2016 Feb; 56(1):115-25. PMID: 26615021.
        View in: PubMed
      19. Kaup AR, Nettiksimmons J, LeBlanc ES, Yaffe K. Memory complaints and risk of cognitive impairment after nearly 2 decades among older women. Neurology. 2015 Oct 28. PMID: 26511452.
        View in: PubMed
      20. Espeland MA, Brinton RD, Hugenschmidt C, Manson JE, Craft S, Yaffe K, Weitlauf J, Vaughan L, Johnson KC, Padula CB, Jackson RD, Resnick SM. Impact of Type 2 Diabetes and Postmenopausal Hormone Therapy on Incidence of Cognitive Impairment in Older Women. Diabetes Care. 2015 Dec; 38(12):2316-24. PMID: 26486190.
        View in: PubMed
      21. Cade BE, Gottlieb DJ, Lauderdale DS, Bennett DA, Buchman AS, Buxbaum SG, De Jager PL, Evans DS, Fülöp T, Gharib SA, Johnson WC, Kim H, Larkin EK, Lee SK, Lim AS, Punjabi NM, Shin C, Stone KL, Tranah GJ, Weng J, Yaffe K, Zee PC, Patel SR, Zhu X, Redline S, Saxena R. Common variants in DRD2 are associated with sleep duration: the CARe consortium. Hum Mol Genet. 2016 Jan 1; 25(1):167-79. PMID: 26464489.
        View in: PubMed
      22. Naples JG, Marcum ZA, Perera S, Gray SL, Newman AB, Simonsick EM, Yaffe K, Shorr RI, Hanlon JT. Concordance Between Anticholinergic Burden Scales. J Am Geriatr Soc. 2015 Oct; 63(10):2120-4. PMID: 26480974.
        View in: PubMed
      23. Brown PJ, Roose SP, Zhang J, Wall M, Rutherford BR, Ayonayon HN, Butters MA, Harris T, Newman AB, Satterfield S, Simonsick EM, Yaffe K. Inflammation, Depression, and Slow Gait: A High Mortality Phenotype in Later Life. J Gerontol A Biol Sci Med Sci. 2016 Feb; 71(2):221-7. PMID: 26392405.
        View in: PubMed
      24. Tranah GJ, Yaffe K, Katzman SM, Lam ET, Pawlikowska L, Kwok PY, Schork NJ, Manini TM, Kritchevsky S, Thomas F, Newman AB, Harris TB, Coleman AL, Gorin MB, Helzner EP, Rowbotham MC, Browner WS, Cummings SR. Mitochondrial DNA Heteroplasmy Associations With Neurosensory and Mobility Function in Elderly Adults. J Gerontol A Biol Sci Med Sci. 2015 Nov; 70(11):1418-24. PMID: 26328603.
        View in: PubMed
      25. Poelke G, Ventura MI, Byers AL, Yaffe K, Sudore R, Barnes DE. Leisure activities and depressive symptoms in older adults with cognitive complaints. Int Psychogeriatr. 2016 Jan; 28(1):63-9. PMID: 26299193.
        View in: PubMed
      26. Murphy RA, Hagaman AK, Reinders I, Steeves JA, Newman AB, Rubin SM, Satterfield S, Kritchevsky SB, Yaffe K, Ayonayon HN, Nagin DS, Simonsick EM, Penninx BW, Harris TB. Depressive Trajectories and Risk of Disability and Mortality in Older Adults: Longitudinal Findings From the Health, Aging, and Body Composition Study. J Gerontol A Biol Sci Med Sci. 2016 Feb; 71(2):228-35. PMID: 26273025.
        View in: PubMed
      27. Kaup AR, Nettiksimmons J, Yaffe K. Diabetes Mellitus and Cognitive Resilience-Reply. JAMA Neurol. 2015 Aug 1; 72(8):949-50. PMID: 26258741.
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      28. Metti AL, Aizenstein H, Yaffe K, Boudreau RM, Newman A, Launer L, Gianaros PJ, Lopez OL, Saxton J, Ives DG, Kritchevsky S, Vallejo AN, Rosano C. Trajectories of peripheral interleukin-6, structure of the hippocampus, and cognitive impairment over 14 years in older adults. Neurobiol Aging. 2015 Nov; 36(11):3038-44. PMID: 26279115.
        View in: PubMed
      29. Hunt LJ, Covinsky KE, Yaffe K, Stephens CE, Miao Y, Boscardin WJ, Smith AK. Pain in Community-Dwelling Older Adults with Dementia: Results from the National Health and Aging Trends Study. J Am Geriatr Soc. 2015 Aug; 63(8):1503-11. PMID: 26200445.
        View in: PubMed
      30. Gardner RC, Hess CP, Brus-Ramer M, Possin KL, Cohn-Sheehy BI, Kramer JH, Berger MS, Yaffe K, Miller B, Rabinovici GD. Cavum Septum Pellucidum in Retired American Pro-Football Players. J Neurotrauma. 2016 Jan 1; 33(1):157-61. PMID: 25970145.
        View in: PubMed
      31. Espeland MA, Brinton RD, Manson JE, Yaffe K, Hugenschmidt C, Vaughan L, Craft S, Edwards BJ, Casanova R, Masaki K, Resnick SM. Postmenopausal hormone therapy, type 2 diabetes mellitus, and brain volumes. Neurology. 2015 Sep 29; 85(13):1131-8. PMID: 26163429.
        View in: PubMed
      32. Mayeda ER, Haan MN, Yaffe K, Kanaya AM, Neuhaus J. Does Type 2 Diabetes Increase Rate of Cognitive Decline in Older Mexican Americans? Alzheimer Dis Assoc Disord. 2015 Jul-Sep; 29(3):206-12. PMID: 25650694.
        View in: PubMed
      33. Gustafson DR, Clare Morris M, Scarmeas N, Shah RC, Sijben J, Yaffe K, Zhu X. New Perspectives on Alzheimer's Disease and Nutrition. J Alzheimers Dis. 2015 Jun 26; 46(4):1111-27. PMID: 26402637.
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      34. Zeki Al Hazzouri A, Vittinghoff E, Sidney S, Reis JP, Jacobs DR, Yaffe K. Intima-Media Thickness and Cognitive Function in Stroke-Free Middle-Aged Adults: Findings From the Coronary Artery Risk Development in Young Adults Study. Stroke. 2015 Aug; 46(8):2190-6. PMID: 26106116.
        View in: PubMed
      35. Carty CL, Keene KL, Cheng YC, Meschia JF, Chen WM, Nalls M, Bis JC, Kittner SJ, Rich SS, Tajuddin S, Zonderman AB, Evans MK, Langefeld CD, Gottesman R, Mosley TH, Shahar E, Woo D, Yaffe K, Liu Y, Sale MM, Dichgans M, Malik R, Longstreth WT, Mitchell BD, Psaty BM, Kooperberg C, Reiner A, Worrall BB, Fornage M. Meta-Analysis of Genome-Wide Association Studies Identifies Genetic Risk Factors for Stroke in African Americans. Stroke. 2015 Aug; 46(8):2063-8. PMID: 26089329.
        View in: PubMed
      36. Blazer DG, Yaffe K, Karlawish J. Cognitive aging: a report from the Institute of Medicine. JAMA. 2015 Jun 2; 313(21):2121-2. PMID: 25875498.
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      37. Gardner RC, Burke JF, Nettiksimmons J, Goldman S, Tanner CM, Yaffe K. Traumatic brain injury in later life increases risk for Parkinson disease. Ann Neurol. 2015 Jun; 77(6):987-95. PMID: 25726936.
        View in: PubMed
      38. Maglione JE, Nievergelt CM, Parimi N, Evans DS, Ancoli-Israel S, Stone KL, Yaffe K, Redline S, Tranah GJ. Associations of PER3 and RORA Circadian Gene Polymorphisms and Depressive Symptoms in Older Adults. Am J Geriatr Psychiatry. 2015 Oct; 23(10):1075-87. PMID: 25892098.
        View in: PubMed
      39. Gardner RC, Yaffe K. Epidemiology of mild traumatic brain injury and neurodegenerative disease. Mol Cell Neurosci. 2015 May; 66(Pt B):75-80. PMID: 25748121.
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      40. Blackwell T, Yaffe K, Laffan A, Redline S, Ancoli-Israel S, Ensrud KE, Song Y, Stone KL. Associations between sleep-disordered breathing, nocturnal hypoxemia, and subsequent cognitive decline in older community-dwelling men: the osteoporotic fractures in men sleep study. J Am Geriatr Soc. 2015 Mar; 63(3):453-61. PMID: 25803785.
        View in: PubMed
      41. Kaup AR, Nettiksimmons J, Harris TB, Sink KM, Satterfield S, Metti AL, Ayonayon HN, Yaffe K. Cognitive Resilience to Apolipoprotein E e4: Contributing Factors in Black and White Older Adults. JAMA Neurol. 2015 Mar 1; 72(3):340-8. PMID: 25599330.
        View in: PubMed
      42. Song Y, Blackwell T, Yaffe K, Ancoli-Israel S, Redline S, Stone KL. Relationships Between Sleep Stages and Changes in Cognitive Function in Older Men: The MrOS Sleep Study. Sleep. 2015; 38(3):411-21. PMID: 25325465.
        View in: PubMed
      43. Yaffe K, Nettiksimmons J, Yesavage J, Byers A. Sleep Quality and Risk of Dementia Among Older Male Veterans. Am J Geriatr Psychiatry. 2015 Jun; 23(6):651-4. PMID: 25794635.
        View in: PubMed
      44. Barnes DE, Mehling W, Wu E, Beristianos M, Yaffe K, Skultety K, Chesney MA. Preventing Loss of Independence through Exercise (PLIÉ): A Pilot Clinical Trial in Older Adults with Dementia. PLoS One. 2015; 10(2):e0113367. PMID: 25671576.
        View in: PubMed
      45. Tian Q, Glynn NW, Erickson KI, Aizenstein HJ, Simonsick EM, Yaffe K, Harris TB, Kritchevsky SB, Boudreau RM, Newman AB, Lopez OL, Saxton J, Rosano C. Objective measures of physical activity, white matter integrity and cognitive status in adults over age 80. Behav Brain Res. 2015 May 1; 284:51-7. PMID: 25655514.
        View in: PubMed
      46. Nettiksimmons J, Ayonayon H, Harris T, Phillips C, Rosano C, Satterfield S, Yaffe K. Development and validation of risk index for cognitive decline using blood-derived markers. Neurology. 2015 Feb 17; 84(7):696-702. PMID: 25609760.
        View in: PubMed
      47. Nadkarni NK, Perera S, Hanlon JT, Lopez O, Newman AB, Aizenstein H, Elam M, Harris TB, Kritchevsky S, Yaffe K, Rosano C. Statins and brain integrity in older adults: Secondary analysis of the Health ABC study. Alzheimers Dement. 2015 Oct; 11(10):1202-11. PMID: 25592659.
        View in: PubMed
      48. Liu G, Allen B, Lopez O, Aizenstein H, Boudreau R, Newman A, Yaffe K, Kritchevsky S, Launer L, Satterfield S, Simonsick E, Rosano C. Racial Differences in Gray Matter Integrity by Diffusion Tensor in Black and White Octogenarians. Curr Alzheimer Res. 2015; 12(7):648-54. PMID: 25387332.
        View in: PubMed
      49. Sin NL, Yaffe K, Whooley MA. Depressive symptoms, cardiovascular disease severity, and functional status in older adults with coronary heart disease: the heart and soul study. J Am Geriatr Soc. 2015 Jan; 63(1):8-15. PMID: 25597554.
        View in: PubMed
      50. Deckers K, van Boxtel MP, Schiepers OJ, de Vugt M, Muñoz Sánchez JL, Anstey KJ, Brayne C, Dartigues JF, Engedal K, Kivipelto M, Ritchie K, Starr JM, Yaffe K, Irving K, Verhey FR, Köhler S. Target risk factors for dementia prevention: a systematic review and Delphi consensus study on the evidence from observational studies. Int J Geriatr Psychiatry. 2015 Mar; 30(3):234-46. PMID: 25504093.
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      51. Beristianos MH, Yaffe K, Cohen B, Byers AL. PTSD and Risk of Incident Cardiovascular Disease in Aging Veterans. Am J Geriatr Psychiatry. 2016 Mar; 24(3):192-200. PMID: 25555625.
        View in: PubMed
      52. Lee SJ, Ritchie CS, Yaffe K, Stijacic Cenzer I, Barnes DE. A clinical index to predict progression from mild cognitive impairment to dementia due to Alzheimer's disease. PLoS One. 2014; 9(12):e113535. PMID: 25486250.
        View in: PubMed
      53. Chen DS, Betz J, Yaffe K, Ayonayon HN, Kritchevsky S, Martin KR, Harris TB, Purchase-Helzner E, Satterfield S, Xue QL, Pratt S, Simonsick EM, Lin FR. Association of hearing impairment with declines in physical functioning and the risk of disability in older adults. J Gerontol A Biol Sci Med Sci. 2015 May; 70(5):654-61. PMID: 25477427.
        View in: PubMed
      54. Gardner RC, Burke JF, Nettiksimmons J, Kaup A, Barnes DE, Yaffe K. Dementia Risk After Traumatic Brain Injury vs Nonbrain Trauma: The Role of Age and Severity. JAMA Neurol. 2014 Dec 1; 71(12):1490-7. PMID: 25347255.
        View in: PubMed
      55. Walsh CM, Blackwell T, Tranah GJ, Stone KL, Ancoli-Israel S, Redline S, Paudel M, Kramer JH, Yaffe K. Weaker Circadian Activity Rhythms are Associated with Poorer Executive Function in Older Women. Sleep. 2014; 37(12):2009-16. PMID: 25337947.
        View in: PubMed
      56. Pa J, Goodson W, Bloch A, King AC, Yaffe K, Barnes DE. Effect of exercise and cognitive activity on self-reported sleep quality in community-dwelling older adults with cognitive complaints: a randomized controlled trial. J Am Geriatr Soc. 2014 Dec; 62(12):2319-26. PMID: 25516028.
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      57. Mayeda ER, Whitmer RA, Yaffe K. Diabetes and cognition. Clin Geriatr Med. 2015 Feb; 31(1):101-15, ix. PMID: 25453304.
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      58. Mayeda ER, Haan MN, Neuhaus J, Yaffe K, Knopman DS, Sharrett AR, Griswold ME, Mosley TH. Type 2 Diabetes and Cognitive Decline Over 14 Years in Middle-Aged African Americans and Whites: The ARIC Brain MRI Study. Neuroepidemiology. 2014; 43(3-4):220-7. PMID: 25402639.
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      59. Bettcher BM, Yaffe K, Boudreau RM, Neuhaus J, Aizenstein H, Ding J, Kritchevsky SB, Launer LJ, Liu Y, Satterfield S, Rosano C. Declines in inflammation predict greater white matter microstructure in older adults. Neurobiol Aging. 2015 Feb; 36(2):948-54. PMID: 25554492.
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      60. Katzman SM, Strotmeyer ES, Nalls MA, Zhao Y, Mooney S, Schork N, Newman AB, Harris TB, Yaffe K, Cummings SR, Liu Y, Tranah GJ. Mitochondrial DNA Sequence Variation Associated With Peripheral Nerve Function in the Elderly. J Gerontol A Biol Sci Med Sci. 2015 Nov; 70(11):1400-8. PMID: 25394619.
        View in: PubMed
      61. Spira AP, Stone KL, Rebok GW, Punjabi NM, Redline S, Ancoli-Israel S, Yaffe K. Sleep-disordered breathing and functional decline in older women. J Am Geriatr Soc. 2014 Nov; 62(11):2040-6. PMID: 25376169.
        View in: PubMed
      62. Spira AP, Chen-Edinboro LP, Wu MN, Yaffe K. Impact of sleep on the risk of cognitive decline and dementia. Curr Opin Psychiatry. 2014 Nov; 27(6):478-83. PMID: 25188896.
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      63. Slinin Y, Peters KW, Ishani A, Yaffe K, Fink HA, Stone KL, Steffes M, Ensrud KE. Cystatin C and cognitive impairment 10 years later in older women. J Gerontol A Biol Sci Med Sci. 2015 Jun; 70(6):771-8. PMID: 25362662.
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      64. Williams JA, Sink KM, Tooze JA, Atkinson HH, Cauley JA, Yaffe K, Tylavsky FA, Rubin SM, Simonsick EM, Kritchevsky SB, Houston DK. Low 25-hydroxyvitamin d concentrations predict incident depression in well-functioning older adults: the health, aging, and body composition study. J Gerontol A Biol Sci Med Sci. 2015 Jun; 70(6):757-63. PMID: 25326643.
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      65. Yaffe K, Falvey CM, Hoang T. Connections between sleep and cognition in older adults. Lancet Neurol. 2014 Oct; 13(10):1017-28. PMID: 25231524.
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      66. Fargo KN, Aisen P, Albert M, Au R, Corrada MM, DeKosky S, Drachman D, Fillit H, Gitlin L, Haas M, Herrup K, Kawas C, Khachaturian AS, Khachaturian ZS, Klunk W, Knopman D, Kukull WA, Lamb B, Logsdon RG, Maruff P, Mesulam M, Mobley W, Mohs R, Morgan D, Nixon RA, Paul S, Petersen R, Plassman B, Potter W, Reiman E, Reisberg B, Sano M, Schindler R, Schneider LS, Snyder PJ, Sperling RA, Yaffe K, Bain LJ, Thies WH, Carrillo MC. 2014 Report on the Milestones for the US National Plan to Address Alzheimer's Disease. Alzheimers Dement. 2014 Oct; 10(5 Suppl):S430-52. PMID: 25341459.
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      67. Tinklenberg JR, Kraemer HC, Yaffe K, O'Hara R, Ringman JM, Ashford JW, Yesavage JA, Taylor JL. Donepezil treatment in ethnically diverse patients with Alzheimer disease. Am J Geriatr Psychiatry. 2015 Apr; 23(4):384-90. PMID: 25747405.
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      68. Yaffe K, Boustani M. Benzodiazepines and risk of Alzheimer's disease. BMJ. 2014; 349:g5312. PMID: 25205606.
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      69. Tian Q, Simonsick EM, Erickson KI, Aizenstein HJ, Glynn NW, Boudreau RM, Newman AB, Kritchevsky SB, Yaffe K, Harris T, Rosano C. Cardiorespiratory fitness and brain diffusion tensor imaging in adults over 80 years of age. Brain Res. 2014 Nov 7; 1588:63-72. PMID: 25204690; PMCID: PMC4252614 [Available on 11/07/15].
      70. Bettcher BM, Watson CL, Walsh CM, Lobach IV, Neuhaus J, Miller JW, Green R, Patel N, Dutt S, Busovaca E, Rosen HJ, Yaffe K, Miller BL, Kramer JH. Interleukin-6, age, and corpus callosum integrity. PLoS One. 2014; 9(9):e106521. PMID: 25188448; PMCID: PMC4154691.
      71. Rosano C, Abebe KZ, Aizenstein HJ, Boudreau R, Jennings JR, Venkatraman V, Harris TB, Yaffe K, Satterfield S, Newman AB. Longitudinal systolic blood pressure characteristics and integrity of white matter tracts in a cohort of very old black and white adults. Am J Hypertens. 2015 Mar; 28(3):326-34. PMID: 25159083.
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      72. Yano Y, Ning H, Allen N, Reis JP, Launer LJ, Liu K, Yaffe K, Greenland P, Lloyd-Jones DM. Long-term blood pressure variability throughout young adulthood and cognitive function in midlife: the Coronary Artery Risk Development in Young Adults (CARDIA) study. Hypertension. 2014 Nov; 64(5):983-8. PMID: 25156174; PMCID: PMC4192076 [Available on 11/01/15].
      73. Tudorascu DL, Rosano C, Venkatraman VK, MacCloud RL, Harris T, Yaffe K, Newman AB, Aizenstein HJ. Multimodal MRI markers support a model of small vessel ischemia for depressive symptoms in very old adults. Psychiatry Res. 2014 Nov 30; 224(2):73-80. PMID: 25205441; PMCID: PMC4195799 [Available on 11/30/15].
      74. Yaffe K, Kurella-Tamura M, Ackerson L, Hoang TD, Anderson AH, Duckworth M, Go AS, Krousel-Wood M, Kusek JW, Lash JP, Ojo A, Robinson N, Sehgal AR, Sondheimer JH, Steigerwalt S, Townsend RR. Higher levels of cystatin C are associated with worse cognitive function in older adults with chronic kidney disease: the chronic renal insufficiency cohort cognitive study. J Am Geriatr Soc. 2014 Sep; 62(9):1623-9. PMID: 25125225; PMCID: PMC4201363 [Available on 09/01/15].
      75. Norton S, Matthews FE, Barnes DE, Yaffe K, Brayne C. Potential for primary prevention of Alzheimer's disease: an analysis of population-based data. Lancet Neurol. 2014 Aug; 13(8):788-94. PMID: 25030513.
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      76. Genther DJ, Betz J, Pratt S, Kritchevsky SB, Martin KR, Harris TB, Helzner E, Satterfield S, Xue QL, Yaffe K, Simonsick EM, Lin FR. Association of hearing impairment and mortality in older adults. J Gerontol A Biol Sci Med Sci. 2015 Jan; 70(1):85-90. PMID: 25024235.
        View in: PubMed
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      341. Edwards ER, Lindquist K, Yaffe K. Clinical profile and course of cognitively normal patients evaluated in memory disorders clinics. Neurology. 2004 May 11; 62(9):1639-42. PMID: 15136703.
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      342. Kurella M, Ireland C, Hlatky MA, Shlipak MG, Yaffe K, Hulley SB, Chertow GM. Physical and sexual function in women with chronic kidney disease. Am J Kidney Dis. 2004 May; 43(5):868-76. PMID: 15112178.
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      343. Sands LP, Ferreira P, Stewart AL, Brod M, Yaffe K. What explains differences between dementia patients' and their caregivers' ratings of patients' quality of life? Am J Geriatr Psychiatry. 2004 May-Jun; 12(3):272-80. PMID: 15126228.
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      344. Yaffe K. Testosterone and the brain: uncharted territory. Lancet Neurol. 2004 May; 3(5):270. PMID: 15099540.
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      345. Covinsky KE, Yaffe K. Dementia, prognosis, and the needs of patients and caregivers. Ann Intern Med. 2004 Apr 6; 140(7):573-4. PMID: 15068987.
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      346. Barnes DE, Tager IB, Satariano WA, Yaffe K. The relationship between literacy and cognition in well-educated elders. J Gerontol A Biol Sci Med Sci. 2004 Apr; 59(4):390-5. PMID: 15071084.
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      347. Brach JS, Simonsick EM, Kritchevsky S, Yaffe K, Newman AB. The association between physical function and lifestyle activity and exercise in the health, aging and body composition study. J Am Geriatr Soc. 2004 Apr; 52(4):502-9. PMID: 15066063.
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      348. Du AT, Schuff N, Kramer JH, Ganzer S, Zhu XP, Jagust WJ, Miller BL, Reed BR, Mungas D, Yaffe K, Chui HC, Weiner MW. Higher atrophy rate of entorhinal cortex than hippocampus in AD. Neurology. 2004 Feb 10; 62(3):422-7. PMID: 14872024; PMCID: PMC1820859.
      349. Covinsky KE, Newcomer R, Fox P, Wood J, Sands L, Dane K, Yaffe K. Patient and caregiver characteristics associated with depression in caregivers of patients with dementia. J Gen Intern Med. 2003 Dec; 18(12):1006-14. PMID: 14687259; PMCID: PMC1494966.
      350. Yaffe K, Edwards ER, Lui LY, Zmuda JM, Ferrell RE, Cauley JA. Androgen receptor CAG repeat polymorphism is associated with cognitive function in older men. Biol Psychiatry. 2003 Nov 1; 54(9):943-6. PMID: 14573323.
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      351. Yaffe K, Edwards ER, Covinsky KE, Lui LY, Eng C. Depressive symptoms and risk of mortality in frail, community-living elderly persons. Am J Geriatr Psychiatry. 2003 Sep-Oct; 11(5):561-7. PMID: 14506090.
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      352. Penninx BW, Kritchevsky SB, Yaffe K, Newman AB, Simonsick EM, Rubin S, Ferrucci L, Harris T, Pahor M. Inflammatory markers and depressed mood in older persons: results from the Health, Aging and Body Composition study. Biol Psychiatry. 2003 Sep 1; 54(5):566-72. PMID: 12946885.
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      353. Schuff N, Capizzano AA, Du AT, Amend DL, O'Neill J, Norman D, Jagust WJ, Chui HC, Kramer JH, Reed BR, Miller BL, Yaffe K, Weiner MW. Different patterns of N-acetylaspartate loss in subcortical ischemic vascular dementia and AD. Neurology. 2003 Aug 12; 61(3):358-64. PMID: 12913198; PMCID: PMC1820863.
      354. Yaffe K, Lindquist K, Penninx BW, Simonsick EM, Pahor M, Kritchevsky S, Launer L, Kuller L, Rubin S, Harris T. Inflammatory markers and cognition in well-functioning African-American and white elders. Neurology. 2003 Jul 8; 61(1):76-80. PMID: 12847160.
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      355. Yaffe K. Hormone therapy and the brain: déjà vu all over again? JAMA. 2003 May 28; 289(20):2717-9. PMID: 12771119.
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      356. Newcomer R, Covinsky KE, Clay T, Yaffe K. Predicting 12-month mortality for persons with dementia. J Gerontol B Psychol Sci Soc Sci. 2003 May; 58(3):S187-98. PMID: 12730320.
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      357. Mehta KM, Yaffe K, Langa KM, Sands L, Whooley MA, Covinsky KE. Additive effects of cognitive function and depressive symptoms on mortality in elderly community-living adults. J Gerontol A Biol Sci Med Sci. 2003 May; 58(5):M461-7. PMID: 12730257; PMCID: PMC2939722.
      358. Wolkowitz OM, Kramer JH, Reus VI, Costa MM, Yaffe K, Walton P, Raskind M, Peskind E, Newhouse P, Sack D, De Souza E, Sadowsky C, Roberts E. DHEA treatment of Alzheimer's disease: a randomized, double-blind, placebo-controlled study. Neurology. 2003 Apr 8; 60(7):1071-6. PMID: 12682308.
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      359. Barnes DE, Yaffe K, Satariano WA, Tager IB. A longitudinal study of cardiorespiratory fitness and cognitive function in healthy older adults. J Am Geriatr Soc. 2003 Apr; 51(4):459-65. PMID: 12657064.
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      360. Mehta KM, Simonsick EM, Penninx BW, Schulz R, Rubin SM, Satterfield S, Yaffe K. Prevalence and correlates of anxiety symptoms in well-functioning older adults: findings from the health aging and body composition study. J Am Geriatr Soc. 2003 Apr; 51(4):499-504. PMID: 12657069.
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      361. Covinsky KE, Eng C, Lui LY, Sands LP, Yaffe K. The last 2 years of life: functional trajectories of frail older people. J Am Geriatr Soc. 2003 Apr; 51(4):492-8. PMID: 12657068.
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      362. Whitmer RA, Haan MN, Miller JW, Yaffe K. Hormone replacement therapy and cognitive performance: the role of homocysteine. J Gerontol A Biol Sci Med Sci. 2003 Apr; 58(4):324-30. PMID: 12663696.
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      363. Barton C, Miller B, Yaffe K. Evaluation of the diagnosis and management of cognitive impairment in long-term care. Alzheimer Dis Assoc Disord. 2003 Apr-Jun; 17(2):72-6. PMID: 12794383.
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      364. Du AT, Schuff N, Zhu XP, Jagust WJ, Miller BL, Reed BR, Kramer JH, Mungas D, Yaffe K, Chui HC, Weiner MW. Atrophy rates of entorhinal cortex in AD and normal aging. Neurology. 2003 Feb 11; 60(3):481-6. PMID: 12578931; PMCID: PMC1851672.
      365. Trinh NH, Hoblyn J, Mohanty S, Yaffe K. Efficacy of cholinesterase inhibitors in the treatment of neuropsychiatric symptoms and functional impairment in Alzheimer disease: a meta-analysis. JAMA. 2003 Jan 8; 289(2):210-6. PMID: 12517232.
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      366. Sands LP, Yaffe K, Covinsky K, Chren MM, Counsell S, Palmer R, Fortinsky R, Landefeld CS. Cognitive screening predicts magnitude of functional recovery from admission to 3 months after discharge in hospitalized elders. J Gerontol A Biol Sci Med Sci. 2003 Jan; 58(1):37-45. PMID: 12560409.
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      367. Kramer JH, Yaffe K, Lengenfelder J, Delis DC. Age and gender interactions on verbal memory performance. J Int Neuropsychol Soc. 2003 Jan; 9(1):97-102. PMID: 12570363.
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      368. Lui LY, Stone K, Cauley JA, Hillier T, Yaffe K. Bone loss predicts subsequent cognitive decline in older women: the study of osteoporotic fractures. J Am Geriatr Soc. 2003 Jan; 51(1):38-43. PMID: 12534843.
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      369. Grundman M, Jack CR, Petersen RC, Kim HT, Taylor C, Datvian M, Weiner MF, DeCarli C, DeKosky ST, van Dyck C, Darvesh S, Yaffe K, Kaye J, Ferris SH, Thomas RG, Thal LJ. Hippocampal volume is associated with memory but not monmemory cognitive performance in patients with mild cognitive impairment. J Mol Neurosci. 2003; 20(3):241-8. PMID: 14501003.
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      370. Grady D, Yaffe K, Kristof M, Lin F, Richards C, Barrett-Connor E. Effect of postmenopausal hormone therapy on cognitive function: the Heart and Estrogen/progestin Replacement Study. Am J Med. 2002 Nov; 113(7):543-8. PMID: 12459399.
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      371. Sands LP, Yaffe K, Lui LY, Stewart A, Eng C, Covinsky K. The effects of acute illness on ADL decline over 1 year in frail older adults with and without cognitive impairment. J Gerontol A Biol Sci Med Sci. 2002 Jul; 57(7):M449-54. PMID: 12084807.
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      372. Du AT, Schuff N, Laakso MP, Zhu XP, Jagust WJ, Yaffe K, Kramer JH, Miller BL, Reed BR, Norman D, Chui HC, Weiner MW. Effects of subcortical ischemic vascular dementia and AD on entorhinal cortex and hippocampus. Neurology. 2002 Jun 11; 58(11):1635-41. PMID: 12058091; PMCID: PMC1820858.
      373. Mehta KM, Yaffe K, Covinsky KE. Cognitive impairment, depressive symptoms, and functional decline in older people. J Am Geriatr Soc. 2002 Jun; 50(6):1045-50. PMID: 12110064; PMCID: PMC2939718.
      374. Yaffe K, Fox P, Newcomer R, Sands L, Lindquist K, Dane K, Covinsky KE. Patient and caregiver characteristics and nursing home placement in patients with dementia. JAMA. 2002 Apr 24; 287(16):2090-7. PMID: 11966383.
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      375. Yaffe K, Lui LY, Grady D, Stone K, Morin P. Estrogen receptor 1 polymorphisms and risk of cognitive impairment in older women. Biol Psychiatry. 2002 Apr 15; 51(8):677-82. PMID: 11955468.
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      376. Yaffe K, Lui LY, Zmuda J, Cauley J. Sex hormones and cognitive function in older men. J Am Geriatr Soc. 2002 Apr; 50(4):707-12. PMID: 11982672.
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      377. Schuff N, Capizzano AA, Du AT, Amend DL, O'Neill J, Norman D, Kramer J, Jagust W, Miller B, Wolkowitz OM, Yaffe K, Weiner MW. Selective reduction of N-acetylaspartate in medial temporal and parietal lobes in AD. Neurology. 2002 Mar 26; 58(6):928-35. PMID: 11914410; PMCID: PMC1851674.
      378. Yaffe K, Barrett-Connor E, Lin F, Grady D. Serum lipoprotein levels, statin use, and cognitive function in older women. Arch Neurol. 2002 Mar; 59(3):378-84. PMID: 11890840.
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      379. Yaffe K. Estrogens, selective estrogen receptor modulators, and dementia: what is the evidence? Ann N Y Acad Sci. 2001 Dec; 949:215-22. PMID: 11795356.
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      380. Covinsky KE, Eng C, Lui LY, Sands LP, Sehgal AR, Walter LC, Wieland D, Eleazer GP, Yaffe K. Reduced employment in caregivers of frail elders: impact of ethnicity, patient clinical characteristics, and caregiver characteristics. J Gerontol A Biol Sci Med Sci. 2001 Nov; 56(11):M707-13. PMID: 11682579.
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      381. Du AT, Schuff N, Amend D, Laakso MP, Hsu YY, Jagust WJ, Yaffe K, Kramer JH, Reed B, Norman D, Chui HC, Weiner MW. Magnetic resonance imaging of the entorhinal cortex and hippocampus in mild cognitive impairment and Alzheimer's disease. J Neurol Neurosurg Psychiatry. 2001 Oct; 71(4):441-7. PMID: 11561025; PMCID: PMC1763497.
      382. Yaffe K, Barnes D, Nevitt M, Lui LY, Covinsky K. A prospective study of physical activity and cognitive decline in elderly women: women who walk. Arch Intern Med. 2001 Jul 23; 161(14):1703-8. PMID: 11485502.
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      383. Yaffe K, Krueger K, Sarkar S, Grady D, Barrett-Connor E, Cox DA, Nickelsen T. Cognitive function in postmenopausal women treated with raloxifene. N Engl J Med. 2001 Apr 19; 344(16):1207-13. PMID: 11309635.
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      384. Yaffe K, Lui LY, Grady D, Cauley J, Kramer J, Cummings SR. Cognitive decline in women in relation to non-protein-bound oestradiol concentrations. Lancet. 2000 Aug 26; 356(9231):708-12. PMID: 11085689.
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      385. Yaffe K, Haan M, Byers A, Tangen C, Kuller L. Estrogen use, APOE, and cognitive decline: evidence of gene-environment interaction. Neurology. 2000 May 23; 54(10):1949-54. PMID: 10822435.
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      386. Kusdra L, Rempel H, Yaffe K, Pulliam L. Elevation of CD69+ monocyte/macrophages in patients with Alzheimer's disease. Immunobiology. 2000 May; 202(1):26-33. PMID: 10879686.
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      387. Covinsky KE, Fuller JD, Yaffe K, Johnston CB, Hamel MB, Lynn J, Teno JM, Phillips RS. Communication and decision-making in seriously ill patients: findings of the SUPPORT project. The Study to Understand Prognoses and Preferences for Outcomes and Risks of Treatments. J Am Geriatr Soc. 2000 May; 48(5 Suppl):S187-93. PMID: 10809474.
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      388. Yaffe K, Browner W, Cauley J, Launer L, Harris T. Association between bone mineral density and cognitive decline in older women. J Am Geriatr Soc. 1999 Oct; 47(10):1176-82. PMID: 10522949.
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      389. Yaffe K, Blackwell T, Gore R, Sands L, Reus V, Browner WS. Depressive symptoms and cognitive decline in nondemented elderly women: a prospective study. Arch Gen Psychiatry. 1999 May; 56(5):425-30. PMID: 10232297.
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      390. Yaffe K, Yaffe SJ. Commentary: Long-term cognitive effects of drugs used during labor. West J Med. 1999 May; 170(5):262. PMID: 18751141.
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      391. Yaffe K, Grady D, Pressman A, Cummings S. Serum estrogen levels, cognitive performance, and risk of cognitive decline in older community women. J Am Geriatr Soc. 1998 Jul; 46(7):816-21. PMID: 9670866.
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      392. Yaffe K, Ettinger B, Pressman A, Seeley D, Whooley M, Schaefer C, Cummings S. Neuropsychiatric function and dehydroepiandrosterone sulfate in elderly women: a prospective study. Biol Psychiatry. 1998 May 1; 43(9):694-700. PMID: 9583004.
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      393. Yaffe K, Sawaya G, Lieberburg I, Grady D. Estrogen therapy in postmenopausal women: effects on cognitive function and dementia. JAMA. 1998 Mar 4; 279(9):688-95. PMID: 9496988.
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      394. Yaffe K, Cauley J, Sands L, Browner W. Apolipoprotein E phenotype and cognitive decline in a prospective study of elderly community women. Arch Neurol. 1997 Sep; 54(9):1110-4. PMID: 9311354.
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      395. Yaffe K, Ferriero D, Barkovich AJ, Rowley H. Reversible MRI abnormalities following seizures. Neurology. 1995 Jan; 45(1):104-8. PMID: 7824097.
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      396. Yaffe K, Lowenstein DH. Prognostic factors of pentobarbital therapy for refractory generalized status epilepticus. Neurology. 1993 May; 43(5):895-900. PMID: 8492944.
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      397. Yaffe KL. Drug hazards. Md State Med J. 1979 Jun; 28(6):43. PMID: 491768.
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      398. Yaffe KL. The physician's role in narcotic abuse. Md State Med J. 1979 Mar; 28(3):36-7. PMID: 431141.
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