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    Lewis Lanier, PhD

    TitleProfessor
    SchoolUCSF School of Medicine
    DepartmentMicrobiology and Immunology
    AddressCore Campus, HSE
    San Francisco CA 94143
    Phone415-514-0829
      Other Positions
      TitleChair, Microbiology and Immunology


       Biography 
       Awards and Honors
      University of California San Francisco2013J. Michael Bishop MD Distinguished Professor
      University of North Carolina - Chapel Hill2013Distinguished UNC Alumnus Award
      American Academy of Arts and Sciences2011Member
      University of California San Francisco2011Faculty Research Lecture - Basic Science
      American Academy of Microbiology2011Fellow
      National Academy of Sciences2010Member
      American Association of Immunologists2006 - 2007President
      American Society for Histocompatibility & Immunogenetics2005Rose Payne Award
      American Cancer Society2003Research Professor
      Cancer Research Institute2002William B Coley Award for Distinguished Research in Basic and Tumor
      American Association of Immunologists 2001Distinguished Service Award
      Becton Dickinson1990Research Fellow
      Damon Runyon - Walter Winchell Cancer Fund1979 - 1981Postdoctoral Fellow

       Overview 
       Overview
      Natural killer (NK) cells are a type of white blood cell that provides protection against microbial pathogens and tumors. Since the early 1980’s, our lab has investigated how NK cells distinguish between normal healthy cells and cells that are transformed or infected with viruses. NK cells express a diverse array of inhibitory and activating receptors on their cells surface that bind to ligands expressed on the cell surface of potential target cells. When encountering healthy cells, signals transmitted by inhibitory NK receptors dominate and prevent autoimmunity, whereas the loss of ligands for the inhibitory receptors or the upregulation of ligands for the activating NK receptors on infected or transformed cells allows NK cells to kill these abnormal cells and secrete cytokine that influence the subsequent response by T cells and B cells. We have developed mouse models systems in which key signaling molecules such as DAP10 and DAP12 have been ablated to explore the physiological role of these NK receptors in resistance to viral infections (cytomegalovirus, poxviruses, and influenza) and primary tumorigenesis.


       ORNG Applications 
       Websites
       In The News
       Awarded Grants
       Global Health
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       Bibliographic 
       Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Weinger JG, Plaisted WC, Maciejewski SM, Lanier LL, Walsh CM, Lane TE. Activating Receptor NKG2D Targets RAE-1-Expressing Allogeneic Neural Precursor Cells in a Viral Model of Multiple Sclerosis. Stem Cells. 2014 Oct; 32(10):2690-701.
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      2. Lanier LL. Just the FACS. J Immunol. 2014 Sep 1; 193(5):2043-4.
        View in: PubMed
      3. Lanier LL. Just the FACS. J Immunol. 2014 Sep 1; 193(5):2043-4.
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      4. Crane CA, Austgen K, Haberthur K, Hofmann C, Moyes KW, Avanesyan L, Fong L, Campbell MJ, Cooper S, Oakes SA, Parsa AT, Lanier LL. Immune evasion mediated by tumor-derived lactate dehydrogenase induction of NKG2D ligands on myeloid cells in glioblastoma patients. Proc Natl Acad Sci U S A. 2014 Sep 2; 111(35):12823-8.
        View in: PubMed
      5. Du J, Lopez-Verges S, Pitcher BN, Johnson J, Jung SH, Zhou L, Hsu K, Czuczman MS, Cheson B, Kaplan L, Lanier LL, Venstrom JM. CALGB 150905 (Alliance): Rituximab Broadens the Antilymphoma Response by Activating Unlicensed NK Cells. Cancer Immunol Res. 2014 Sep; 2(9):878-89.
        View in: PubMed
      6. Min-Oo G, Bezman NA, Madera S, Sun JC, Lanier LL. Proapoptotic Bim regulates antigen-specific NK cell contraction and the generation of the memory NK cell pool after cytomegalovirus infection. J Exp Med. 2014 Jun 30; 211(7):1289-96.
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      7. Orbelyan GA, Tang F, Sally B, Solus J, Meresse B, Ciszewski C, Grenier JC, Barreiro LB, Lanier LL, Jabri B. Human NKG2E Is Expressed and Forms an Intracytoplasmic Complex with CD94 and DAP12. J Immunol. 2014 Jul 15; 193(2):610-6.
        View in: PubMed
      8. Kalinowski A, Ueki I, Min-Oo G, Ballon-Landa E, Knoff D, Galen B, Lanier LL, Nadel JA, Koff JL. EGFR activation suppresses respiratory virus-induced IRF1-dependent CXCL10 production. Am J Physiol Lung Cell Mol Physiol. 2014 Jul 15; 307(2):L186-96.
        View in: PubMed
      9. Hendricks DW, Balfour HH, Dunmire SK, Schmeling DO, Hogquist KA, Lanier LL. Cutting Edge: NKG2ChiCD57+ NK Cells Respond Specifically to Acute Infection with Cytomegalovirus and Not Epstein-Barr Virus. J Immunol. 2014 May 15; 192(10):4492-6.
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      10. Jin H, Arase N, Hirayasu K, Kohyama M, Suenaga T, Saito F, Tanimura K, Matsuoka S, Ebina K, Shi K, Toyama-Sorimachi N, Yasuda S, Horita T, Hiwa R, Takasugi K, Ohmura K, Yoshikawa H, Saito T, Atsumi T, Sasazuki T, Katayama I, Lanier LL, Arase H. Autoantibodies to IgG/HLA class II complexes are associated with rheumatoid arthritis susceptibility. Proc Natl Acad Sci U S A. 2014 Mar 11; 111(10):3787-92.
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      11. Lanier LL. Of snowflakes and natural killer cell subsets. Nat Biotechnol. 2014 Feb 7; 32(2):140-2.
        View in: PubMed
      12. Nabekura T, Kanaya M, Shibuya A, Fu G, Gascoigne NR, Lanier LL. Costimulatory Molecule DNAM-1 Is Essential for Optimal Differentiation of Memory Natural Killer Cells during Mouse Cytomegalovirus Infection. Immunity. 2014 Feb 20; 40(2):225-34.
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      13. Dangl JL, Lanier LL. Founding father of FACS: Professor Leonard A. Herzenberg (1931–2013). Proc Natl Acad Sci U S A. 2013 Dec 24; 110(52):20848-9.
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      14. Milush JM, López-Vergès S, York VA, Deeks SG, Martin JN, Hecht FM, Lanier LL, Nixon DF. CD56negCD16+ NK cells are activated mature NK cells with impaired effector function during HIV-1 infection. Retrovirology. 2013; 10(1):158.
        View in: PubMed
      15. Hartigan-O'Connor DJ, Lin D, Ryan JC, Shvachko VA, Cozen ML, Segal MR, Terrault NA, Lanier LL, Manos MM, McCune JM. Monocyte Activation by Interferon a Is Associated With Failure to Achieve a Sustained Virologic Response After Treatment for Hepatitis C Virus Infection. J Infect Dis. 2014 May; 209(10):1602-12.
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      16. Kim CC, Lanier LL. Beyond the transcriptome: completion of act one of the Immunological Genome Project. Curr Opin Immunol. 2013 Oct; 25(5):593-7.
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      17. Ueki IF, Min-Oo G, Kalinowski A, Ballon-Landa E, Lanier LL, Nadel JA, Koff JL. Respiratory virus-induced EGFR activation suppresses IRF1-dependent interferon ? and antiviral defense in airway epithelium. J Exp Med. 2013 Sep 23; 210(10):1929-36.
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      18. Co EC, Gormley M, Kapidzic M, Rosen DB, Scott MA, Stolp HA, McMaster M, Lanier LL, Bárcena A, Fisher SJ. Maternal decidual macrophages inhibit NK cell killing of invasive cytotrophoblasts during human pregnancy. Biol Reprod. 2013 Jun; 88(6):155.
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      19. Hosomi S, Chen Z, Baker K, Chen L, Huang YH, Olszak T, Zeissig S, Wang JH, Mandelboim O, Beauchemin N, Lanier LL, Blumberg RS. CEACAM1 on activated NK cells inhibits NKG2D-mediated cytolytic function and signaling. Eur J Immunol. 2013 Sep; 43(9):2473-83.
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      20. Mingueneau M, Kreslavsky T, Gray D, Heng T, Cruse R, Ericson J, Bendall S, Spitzer MH, Nolan GP, Kobayashi K, von Boehmer H, Mathis D, Benoist C. The transcriptional landscape of aß T cell differentiation. Nat Immunol. 2013 Jun; 14(6):619-32.
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      21. Beaulieu AM, Bezman NA, Lee JE, Matloubian M, Sun JC, Lanier LL. MicroRNA function in NK-cell biology. Immunol Rev. 2013 May; 253(1):40-52.
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      22. Jojic V, Shay T, Sylvia K, Zuk O, Sun X, Kang J, Regev A, Koller D. Identification of transcriptional regulators in the mouse immune system. Nat Immunol. 2013 Jun; 14(6):633-43.
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      23. Zawislak CL, Beaulieu AM, Loeb GB, Karo J, Canner D, Bezman NA, Lanier LL, Rudensky AY, Sun JC. Stage-specific regulation of natural killer cell homeostasis and response against viral infection by microRNA-155. Proc Natl Acad Sci U S A. 2013 Apr 23; 110(17):6967-72.
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      24. Min-Oo G, Kamimura Y, Hendricks DW, Nabekura T, Lanier LL. Natural killer cells: walking three paths down memory lane. Trends Immunol. 2013 Jun; 34(6):251-8.
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      25. Lanier LL. Shades of grey--the blurring view of innate and adaptive immunity. Nat Rev Immunol. 2013 Feb; 13(2):73-4.
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      26. Jiang Y, Arase N, Kohyama M, Hirayasu K, Suenaga T, Jin H, Matsumoto M, Shida K, Lanier LL, Saito T, Arase H. Transport of misfolded endoplasmic reticulum proteins to the cell surface by MHC class II molecules. Int Immunol. 2013 Apr; 25(4):235-46.
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      27. Batista MD, Ho EL, Kuebler PJ, Milush JM, Lanier LL, Kallas EG, York VA, Chang D, Liao W, Unemori P, Leslie KS, Maurer T, Nixon DF. Skewed distribution of natural killer cells in psoriasis skin lesions. Exp Dermatol. 2013 Jan; 22(1):64-6.
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      28. Benoist C, Lanier L, Merad M, Mathis D. Consortium biology in immunology: the perspective from the Immunological Genome Project. Nat Rev Immunol. 2012 Oct; 12(10):734-40.
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      29. Bezman NA, Kim CC, Sun JC, Min-Oo G, Hendricks DW, Kamimura Y, Best JA, Goldrath AW, Lanier LL. Molecular definition of the identity and activation of natural killer cells. Nat Immunol. 2012 Oct; 13(10):1000-9.
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      30. Thomas MF, Abdul-Wajid S, Panduro M, Babiarz JE, Rajaram M, Woodruff P, Lanier LL, Heissmeyer V, Ansel KM. Eri1 regulates microRNA homeostasis and mouse lymphocyte development and antiviral function. Blood. 2012 Jul 5; 120(1):130-42.
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      31. Beilke JN, Meagher CT, Hosiawa K, Champsaur M, Bluestone JA, Lanier LL. NK cells are not required for spontaneous autoimmune diabetes in NOD mice. PLoS One. 2012; 7(4):e36011.
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      32. Park CY, Jeker LT, Carver-Moore K, Oh A, Liu HJ, Cameron R, Richards H, Li Z, Adler D, Yoshinaga Y, Martinez M, Nefadov M, Abbas AK, Weiss A, Lanier LL, de Jong PJ, Bluestone JA, Srivastava D, McManus MT. A resource for the conditional ablation of microRNAs in the mouse. Cell Rep. 2012 Apr 19; 1(4):385-91.
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      33. Sun JC, Madera S, Bezman NA, Beilke JN, Kaplan MH, Lanier LL. Proinflammatory cytokine signaling required for the generation of natural killer cell memory. J Exp Med. 2012 May 7; 209(5):947-54.
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      34. Ndhlovu LC, Lopez-Vergès S, Barbour JD, Jones RB, Jha AR, Long BR, Schoeffler EC, Fujita T, Nixon DF, Lanier LL. Tim-3 marks human natural killer cell maturation and suppresses cell-mediated cytotoxicity. Blood. 2012 Apr 19; 119(16):3734-43.
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      35. Nielsen N, Ødum N, Ursø B, Lanier LL, Spee P. Cytotoxicity of CD56(bright) NK cells towards autologous activated CD4+ T cells is mediated through NKG2D, LFA-1 and TRAIL and dampened via CD94/NKG2A. PLoS One. 2012; 7(2):e31959.
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      36. Tietze JK, Wilkins DE, Sckisel GD, Bouchlaka MN, Alderson KL, Weiss JM, Ames E, Bruhn KW, Craft N, Wiltrout RH, Longo DL, Lanier LL, Blazar BR, Redelman D, Murphy WJ. Delineation of antigen-specific and antigen-nonspecific CD8(+) memory T-cell responses after cytokine-based cancer immunotherapy. Blood. 2012 Mar 29; 119(13):3073-83.
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      37. Foley B, Cooley S, Verneris MR, Pitt M, Curtsinger J, Luo X, Lopez-Vergès S, Lanier LL, Weisdorf D, Miller JS. Cytomegalovirus reactivation after allogeneic transplantation promotes a lasting increase in educated NKG2C+ natural killer cells with potent function. Blood. 2012 Mar 15; 119(11):2665-74.
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      38. Chen Z, Chen L, Baker K, Olszak T, Zeissig S, Huang YH, Kuo TT, Mandelboim O, Beauchemin N, Lanier LL, Blumberg RS. CEACAM1 dampens antitumor immunity by down-regulating NKG2D ligand expression on tumor cells. J Exp Med. 2011 Dec 19; 208(13):2633-40.
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      39. Bezman NA, Chakraborty T, Bender T, Lanier LL. miR-150 regulates the development of NK and iNKT cells. J Exp Med. 2011 Dec 19; 208(13):2717-31.
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      40. Sun JC, Lanier LL. NK cell development, homeostasis and function: parallels with CD8? T cells. Nat Rev Immunol. 2011 Oct; 11(10):645-57.
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      41. Lopez-Vergès S, Milush JM, Schwartz BS, Pando MJ, Jarjoura J, York VA, Houchins JP, Miller S, Kang SM, Norris PJ, Nixon DF, Lanier LL. Expansion of a unique CD57?NKG2Chi natural killer cell subset during acute human cytomegalovirus infection. Proc Natl Acad Sci U S A. 2011 Sep 6; 108(36):14725-32.
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      42. Nakano-Yokomizo T, Tahara-Hanaoka S, Nakahashi-Oda C, Nabekura T, Tchao NK, Kadosaki M, Totsuka N, Kurita N, Nakamagoe K, Tamaoka A, Takai T, Yasui T, Kikutani H, Honda S, Shibuya K, Lanier LL, Shibuya A. The immunoreceptor adapter protein DAP12 suppresses B lymphocyte-driven adaptive immune responses. J Exp Med. 2011 Aug 1; 208(8):1661-71.
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      43. Fang M, Orr MT, Spee P, Egebjerg T, Lanier LL, Sigal LJ. CD94 is essential for NK cell-mediated resistance to a lethal viral disease. Immunity. 2011 Apr 22; 34(4):579-89.
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      44. Barao I, Alvarez M, Ames E, Orr MT, Stefanski HE, Blazar BR, Lanier LL, Anderson SK, Redelman D, Murphy WJ. Mouse Ly49G2+ NK cells dominate early responses during both immune reconstitution and activation independently of MHC. Blood. 2011 Jun 30; 117(26):7032-41.
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      45. Sun JC, Lopez-Verges S, Kim CC, DeRisi JL, Lanier LL. NK cells and immune "memory". J Immunol. 2011 Feb 15; 186(4):1891-7.
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      46. Sun JC, Beilke JN, Bezman NA, Lanier LL. Homeostatic proliferation generates long-lived natural killer cells that respond against viral infection. J Exp Med. 2011 Feb 14; 208(2):357-68.
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      47. Hesslein DG, Palacios EH, Sun JC, Beilke JN, Watson SR, Weiss A, Lanier LL. Differential requirements for CD45 in NK-cell function reveal distinct roles for Syk-family kinases. Blood. 2011 Mar 17; 117(11):3087-95.
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      48. Kogure A, Shiratori I, Wang J, Lanier LL, Arase H. PANP is a novel O-glycosylated PILRa ligand expressed in neural tissues. Biochem Biophys Res Commun. 2011 Feb 18; 405(3):428-33.
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      49. Vivier E, Raulet DH, Moretta A, Caligiuri MA, Zitvogel L, Lanier LL, Yokoyama WM, Ugolini S. Innate or adaptive immunity? The example of natural killer cells. Science. 2011 Jan 7; 331(6013):44-9.
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      50. Orr MT, Lanier LL. Natural killer cell licensing during viral infection. Adv Exp Med Biol. 2011; 780:37-44.
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      51. Hesslein DG, Lanier LL. Transcriptional control of natural killer cell development and function. Adv Immunol. 2011; 109:45-85.
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      52. Orr MT, Lanier LL. Inhibitory Ly49 receptors on mouse natural killer cells. Curr Top Microbiol Immunol. 2011; 350:67-87.
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      53. Sun JC, Lanier LL. Versatility in NK cell memory. Immunol Cell Biol. 2011 Mar; 89(3):327-9.
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      54. Orr MT, Wu J, Fang M, Sigal LJ, Spee P, Egebjerg T, Dissen E, Fossum S, Phillips JH, Lanier LL. Development and function of CD94-deficient natural killer cells. PLoS One. 2010; 5(12):e15184.
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      55. Babic M, Pyzik M, Zafirova B, Mitrovic M, Butorac V, Lanier LL, Krmpotic A, Vidal SM, Jonjic S. Cytomegalovirus immunoevasin reveals the physiological role of "missing self" recognition in natural killer cell dependent virus control in vivo. J Exp Med. 2010 Nov 22; 207(12):2663-73.
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      56. Orr MT, Lanier LL. Natural killer cell education and tolerance. Cell. 2010 Sep 17; 142(6):847-56.
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      57. Bezman NA, Cedars E, Steiner DF, Blelloch R, Hesslein DG, Lanier LL. Distinct requirements of microRNAs in NK cell activation, survival, and function. J Immunol. 2010 Oct 1; 185(7):3835-46.
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      58. Beilke JN, Benjamin J, Lanier LL. The requirement for NKG2D in NK cell-mediated rejection of parental bone marrow grafts is determined by MHC class I expressed by the graft recipient. Blood. 2010 Dec 9; 116(24):5208-16.
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      59. Lopez-Vergès S, Milush JM, Pandey S, York VA, Arakawa-Hoyt J, Pircher H, Norris PJ, Nixon DF, Lanier LL. CD57 defines a functionally distinct population of mature NK cells in the human CD56dimCD16+ NK-cell subset. Blood. 2010 Nov 11; 116(19):3865-74.
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      60. Orr MT, Beilke JN, Proekt I, Lanier LL. Natural killer cells in NOD.NK1.1 mice acquire cytolytic function during viral infection and provide protection against cytomegalovirus. Proc Natl Acad Sci U S A. 2010 Sep 7; 107(36):15844-9.
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      61. Sun JC, Beilke JN, Lanier LL. Immune memory redefined: characterizing the longevity of natural killer cells. Immunol Rev. 2010 Jul; 236:83-94.
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      62. Champsaur M, Beilke JN, Ogasawara K, Koszinowski UH, Jonjic S, Lanier LL. Intact NKG2D-independent function of NK cells chronically stimulated with the NKG2D ligand Rae-1. J Immunol. 2010 Jul 1; 185(1):157-65.
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      63. Champsaur M, Lanier LL. Effect of NKG2D ligand expression on host immune responses. Immunol Rev. 2010 May; 235(1):267-85.
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      64. Koth LL, Cambier CJ, Ellwanger A, Solon M, Hou L, Lanier LL, Abram CL, Hamerman JA, Woodruff PG. DAP12 is required for macrophage recruitment to the lung in response to cigarette smoke and chemotaxis toward CCL2. J Immunol. 2010 Jun 1; 184(11):6522-8.
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      65. Orr MT, Murphy WJ, Lanier LL. 'Unlicensed' natural killer cells dominate the response to cytomegalovirus infection. Nat Immunol. 2010 Apr; 11(4):321-7.
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      66. Crane CA, Han SJ, Barry JJ, Ahn BJ, Lanier LL, Parsa AT. TGF-beta downregulates the activating receptor NKG2D on NK cells and CD8+ T cells in glioma patients. Neuro Oncol. 2010 Jan; 12(1):7-13.
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      67. Wang J, Fan Q, Satoh T, Arii J, Lanier LL, Spear PG, Kawaguchi Y, Arase H. Binding of herpes simplex virus glycoprotein B (gB) to paired immunoglobulin-like type 2 receptor alpha depends on specific sialylated O-linked glycans on gB. J Virol. 2009 Dec; 83(24):13042-5.
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      68. Jenne CN, Enders A, Rivera R, Watson SR, Bankovich AJ, Pereira JP, Xu Y, Roots CM, Beilke JN, Banerjee A, Reiner SL, Miller SA, Weinmann AS, Goodnow CC, Lanier LL, Cyster JG, Chun J. T-bet-dependent S1P5 expression in NK cells promotes egress from lymph nodes and bone marrow. J Exp Med. 2009 Oct 26; 206(11):2469-81.
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      69. Milush JM, Long BR, Snyder-Cappione JE, Cappione AJ, York VA, Ndhlovu LC, Lanier LL, Michaëlsson J, Nixon DF. Functionally distinct subsets of human NK cells and monocyte/DC-like cells identified by coexpression of CD56, CD7, and CD4. Blood. 2009 Nov 26; 114(23):4823-31.
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      70. Long BR, Erickson AE, Chapman JM, Barbour JD, Vu BA, Ho EL, Lanier LL, Sauer MM, Carvalho KI, Nixon DF, Kallas EG. Increased number and function of natural killer cells in human immunodeficiency virus 1-positive subjects co-infected with herpes simplex virus 2. Immunology. 2010 Feb; 129(2):186-96.
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      71. Sun JC, Lanier LL. Natural killer cells remember: an evolutionary bridge between innate and adaptive immunity? Eur J Immunol. 2009 Aug; 39(8):2059-64.
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      72. Sun JC, Ma A, Lanier LL. Cutting edge: IL-15-independent NK cell response to mouse cytomegalovirus infection. J Immunol. 2009 Sep 1; 183(5):2911-4.
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      73. Cao W, Bover L, Cho M, Wen X, Hanabuchi S, Bao M, Rosen DB, Wang YH, Shaw JL, Du Q, Li C, Arai N, Yao Z, Lanier LL, Liu YJ. Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction. J Exp Med. 2009 Jul 6; 206(7):1603-14.
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      74. Lanier LL, Sun JC. Do the terms innate and adaptive immunity create conceptual barriers? Nat Rev Immunol. 2009 May; 9(5):302-3.
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      75. Orr MT, Sun JC, Hesslein DG, Arase H, Phillips JH, Takai T, Lanier LL. Ly49H signaling through DAP10 is essential for optimal natural killer cell responses to mouse cytomegalovirus infection. J Exp Med. 2009 Apr 13; 206(4):807-17.
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      76. Kielczewska A, Pyzik M, Sun T, Krmpotic A, Lodoen MB, Munks MW, Babic M, Hill AB, Koszinowski UH, Jonjic S, Lanier LL, Vidal SM. Ly49P recognition of cytomegalovirus-infected cells expressing H2-Dk and CMV-encoded m04 correlates with the NK cell antiviral response. J Exp Med. 2009 Mar 16; 206(3):515-23.
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      77. Buhtoiarov IN, Rakhmilevich AL, Lanier LL, Ranheim EA, Sondel PM. Naive mouse macrophages become activated following recognition of L5178Y lymphoma cells via concurrent ligation of CD40, NKG2D, and CD18 molecules. J Immunol. 2009 Feb 15; 182(4):1940-53.
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      78. Sun JC, Beilke JN, Lanier LL. Adaptive immune features of natural killer cells. Nature. 2009 Jan 29; 457(7229):557-61.
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      79. Lanier LL. DAP10- and DAP12-associated receptors in innate immunity. Immunol Rev. 2009 Jan; 227(1):150-60.
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      80. Sun JC, Lanier LL. The Natural Selection of Herpesviruses and Virus-Specific NK Cell Receptors. Viruses. 2009; 1(3):362.
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      81. Sun JC, Lanier LL. Cutting edge: viral infection breaks NK cell tolerance to "missing self". J Immunol. 2008 Dec 1; 181(11):7453-7.
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      82. Kim CC, Parikh S, Sun JC, Myrick A, Lanier LL, Rosenthal PJ, DeRisi JL. Experimental malaria infection triggers early expansion of natural killer cells. Infect Immun. 2008 Dec; 76(12):5873-82.
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      83. Saether PC, Westgaard IH, Hoelsbrekken SE, Benjamin J, Lanier LL, Fossum S, Dissen E. KLRE/I1 and KLRE/I2: a novel pair of heterodimeric receptors that inversely regulate NK cell cytotoxicity. J Immunol. 2008 Sep 1; 181(5):3177-82.
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      84. Sun JC, Lanier LL. Tolerance of NK cells encountering their viral ligand during development. J Exp Med. 2008 Aug 4; 205(8):1819-28.
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      85. Rosen DB, Cao W, Avery DT, Tangye SG, Liu YJ, Houchins JP, Lanier LL. Functional consequences of interactions between human NKR-P1A and its ligand LLT1 expressed on activated dendritic cells and B cells. J Immunol. 2008 May 15; 180(10):6508-17.
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      86. Lanier LL. Up on the tightrope: natural killer cell activation and inhibition. Nat Immunol. 2008 May; 9(5):495-502.
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      87. Satoh T, Arii J, Suenaga T, Wang J, Kogure A, Uehori J, Arase N, Shiratori I, Tanaka S, Kawaguchi Y, Spear PG, Lanier LL, Arase H. PILRalpha is a herpes simplex virus-1 entry coreceptor that associates with glycoprotein B. Cell. 2008 Mar 21; 132(6):935-44.
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      88. Lanier LL. Evolutionary struggles between NK cells and viruses. Nat Rev Immunol. 2008 Apr; 8(4):259-68.
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      89. Long BR, Ndhlovu LC, Oksenberg JR, Lanier LL, Hecht FM, Nixon DF, Barbour JD. Conferral of enhanced natural killer cell function by KIR3DS1 in early human immunodeficiency virus type 1 infection. J Virol. 2008 May; 82(10):4785-92.
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      90. Fang M, Lanier LL, Sigal LJ. A role for NKG2D in NK cell-mediated resistance to poxvirus disease. PLoS Pathog. 2008 Feb 8; 4(2):e30.
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      91. Wang J, Shiratori I, Satoh T, Lanier LL, Arase H. An essential role of sialylated O-linked sugar chains in the recognition of mouse CD99 by paired Ig-like type 2 receptor (PILR). J Immunol. 2008 Feb 1; 180(3):1686-93.
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      92. Chu CL, Yu YL, Shen KY, Lowell CA, Lanier LL, Hamerman JA. Increased TLR responses in dendritic cells lacking the ITAM-containing adapters DAP12 and FcRgamma. Eur J Immunol. 2008 Jan; 38(1):166-73.
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      93. Michaëlsson J, Long BR, Loo CP, Lanier LL, Spotts G, Hecht FM, Nixon DF. Immune reconstitution of CD56(dim) NK cells in individuals with primary HIV-1 infection treated with interleukin-2. J Infect Dis. 2008 Jan 1; 197(1):117-25.
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      94. Walsh KB, Lanier LL, Lane TE. NKG2D receptor signaling enhances cytolytic activity by virus-specific CD8+ T cells: evidence for a protective role in virus-induced encephalitis. J Virol. 2008 Mar; 82(6):3031-44.
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      95. Walsh KB, Lodoen MB, Edwards RA, Lanier LL, Lane TE. Evidence for differential roles for NKG2D receptor signaling in innate host defense against coronavirus-induced neurological and liver disease. J Virol. 2008 Mar; 82(6):3021-30.
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      96. Kim J, Chang CK, Hayden T, Liu FC, Benjamin J, Hamerman JA, Lanier LL, Kang SM. The activating immunoreceptor NKG2D and its ligands are involved in allograft transplant rejection. J Immunol. 2007 Nov 15; 179(10):6416-20.
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      97. Long BR, Michaelsson J, Loo CP, Ballan WM, Vu BA, Hecht FM, Lanier LL, Chapman JM, Nixon DF. Elevated frequency of gamma interferon-producing NK cells in healthy adults vaccinated against influenza virus. Clin Vaccine Immunol. 2008 Jan; 15(1):120-30.
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      100. Ballan WM, Vu BA, Long BR, Loo CP, Michaëlsson J, Barbour JD, Lanier LL, Wiznia AA, Abadi J, Fennelly GJ, Rosenberg MG, Nixon DF. Natural killer cells in perinatally HIV-1-infected children exhibit less degranulation compared to HIV-1-exposed uninfected children and their expression of KIR2DL3, NKG2C, and NKp46 correlates with disease severity. J Immunol. 2007 Sep 1; 179(5):3362-70.
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      104. Carr WH, Rosen DB, Arase H, Nixon DF, Michaelsson J, Lanier LL. Cutting Edge: KIR3DS1, a gene implicated in resistance to progression to AIDS, encodes a DAP12-associated receptor expressed on NK cells that triggers NK cell activation. J Immunol. 2007 Jan 15; 178(2):647-51.
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      111. Hamerman JA, Jarjoura JR, Humphrey MB, Nakamura MC, Seaman WE, Lanier LL. Cutting edge: inhibition of TLR and FcR responses in macrophages by triggering receptor expressed on myeloid cells (TREM)-2 and DAP12. J Immunol. 2006 Aug 15; 177(4):2051-5.
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      115. Meresse B, Curran SA, Ciszewski C, Orbelyan G, Setty M, Bhagat G, Lee L, Tretiakova M, Semrad C, Kistner E, Winchester RJ, Braud V, Lanier LL, Geraghty DE, Green PH, Guandalini S, Jabri B. Reprogramming of CTLs into natural killer-like cells in celiac disease. J Exp Med. 2006 May 15; 203(5):1343-55.
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      116. Hesslein DG, Takaki R, Hermiston ML, Weiss A, Lanier LL. Dysregulation of signaling pathways in CD45-deficient NK cells leads to differentially regulated cytotoxicity and cytokine production. Proc Natl Acad Sci U S A. 2006 May 2; 103(18):7012-7.
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      117. Shiow LR, Rosen DB, Brdicková N, Xu Y, An J, Lanier LL, Cyster JG, Matloubian M. CD69 acts downstream of interferon-alpha/beta to inhibit S1P1 and lymphocyte egress from lymphoid organs. Nature. 2006 Mar 23; 440(7083):540-4.
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      118. Hamerman JA, Lanier LL. Inhibition of immune responses by ITAM-bearing receptors. Sci STKE. 2006 Jan 31; 2006(320):re1.
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      120. Bui JD, Carayannopoulos LN, Lanier LL, Yokoyama WM, Schreiber RD. IFN-dependent down-regulation of the NKG2D ligand H60 on tumors. J Immunol. 2006 Jan 15; 176(2):905-13.
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      121. Vidal SM, Lanier LL. NK cell recognition of mouse cytomegalovirus-infected cells. Curr Top Microbiol Immunol. 2006; 298:183-206.
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      122. Walsh KB, Lodoen MB, Lanier LL, Lane TE. NKG2D signaling and host defense after mouse hepatitis virus infection of the central nervous system. Adv Exp Med Biol. 2006; 581:369-72.
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      124. Chen S, Kawashima H, Lowe JB, Lanier LL, Fukuda M. Suppression of tumor formation in lymph nodes by L-selectin-mediated natural killer cell recruitment. J Exp Med. 2005 Dec 19; 202(12):1679-89.
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      125. Humphrey MB, Lanier LL, Nakamura MC. Role of ITAM-containing adapter proteins and their receptors in the immune system and bone. Immunol Rev. 2005 Dec; 208:50-65.
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      126. Routes JM, Ryan S, Morris K, Takaki R, Cerwenka A, Lanier LL. Adenovirus serotype 5 E1A sensitizes tumor cells to NKG2D-dependent NK cell lysis and tumor rejection. J Exp Med. 2005 Dec 5; 202(11):1477-82.
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      127. Ogasawara K, Lanier LL. NKG2D in NK and T cell-mediated immunity. J Clin Immunol. 2005 Nov; 25(6):534-40.
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      128. Humphrey MB, Daws MR, Spusta SC, Niemi EC, Torchia JA, Lanier LL, Seaman WE, Nakamura MC. TREM2, a DAP12-associated receptor, regulates osteoclast differentiation and function. J Bone Miner Res. 2006 Feb; 21(2):237-45.
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      129. Shiratori I, Yamaguchi M, Suzukawa M, Yamamoto K, Lanier LL, Saito T, Arase H. Down-regulation of basophil function by human CD200 and human herpesvirus-8 CD200. J Immunol. 2005 Oct 1; 175(7):4441-9.
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      130. Takaki R, Hayakawa Y, Nelson A, Sivakumar PV, Hughes S, Smyth MJ, Lanier LL. IL-21 enhances tumor rejection through a NKG2D-dependent mechanism. J Immunol. 2005 Aug 15; 175(4):2167-73.
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      132. Lanier LL. Missing self, NK cells, and The White Album. J Immunol. 2005 Jun 1; 174(11):6565.
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      134. Desrosiers MP, Kielczewska A, Loredo-Osti JC, Adam SG, Makrigiannis AP, Lemieux S, Pham T, Lodoen MB, Morgan K, Lanier LL, Vidal SM. Epistasis between mouse Klra and major histocompatibility complex class I loci is associated with a new mechanism of natural killer cell-mediated innate resistance to cytomegalovirus infection. Nat Genet. 2005 Jun; 37(6):593-9.
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      135. Ehrlich LI, Ogasawara K, Hamerman JA, Takaki R, Zingoni A, Allison JP, Lanier LL. Engagement of NKG2D by cognate ligand or antibody alone is insufficient to mediate costimulation of human and mouse CD8+ T cells. J Immunol. 2005 Feb 15; 174(4):1922-31.
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      137. Lanier LL. First sighting of the elusive T cell antigen receptor. J Immunol. 2005 Feb 1; 174(3):1143.
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      139. Lodoen MB, Lanier LL. Viral modulation of NK cell immunity. Nat Rev Microbiol. 2005 Jan; 3(1):59-69.
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      142. Bach JF, Bendelac A, Brenner MB, Cantor H, De Libero G, Kronenberg M, Lanier LL, Raulet DH, Shlomchik MJ, von Herrath MG. The role of innate immunity in autoimmunity. J Exp Med. 2004 Dec 20; 200(12):1527-31.
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      143. Lodoen MB, Abenes G, Umamoto S, Houchins JP, Liu F, Lanier LL. The cytomegalovirus m155 gene product subverts natural killer cell antiviral protection by disruption of H60-NKG2D interactions. J Exp Med. 2004 Oct 18; 200(8):1075-81.
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      144. Voehringer D, Rosen DB, Lanier LL, Locksley RM. CD200 receptor family members represent novel DAP12-associated activating receptors on basophils and mast cells. J Biol Chem. 2004 Dec 24; 279(52):54117-23.
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      145. Zingoni A, Sornasse T, Cocks BG, Tanaka Y, Santoni A, Lanier LL. Cross-talk between activated human NK cells and CD4+ T cells via OX40-OX40 ligand interactions. J Immunol. 2004 Sep 15; 173(6):3716-24.
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      146. Meresse B, Chen Z, Ciszewski C, Tretiakova M, Bhagat G, Krausz TN, Raulet DH, Lanier LL, Groh V, Spies T, Ebert EC, Green PH, Jabri B. Coordinated induction by IL15 of a TCR-independent NKG2D signaling pathway converts CTL into lymphokine-activated killer cells in celiac disease. Immunity. 2004 Sep; 21(3):357-66.
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      147. Rosen DB, Araki M, Hamerman JA, Chen T, Yamamura T, Lanier LL. A Structural basis for the association of DAP12 with mouse, but not human, NKG2D. J Immunol. 2004 Aug 15; 173(4):2470-8.
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      148. Ogasawara K, Hamerman JA, Ehrlich LR, Bour-Jordan H, Santamaria P, Bluestone JA, Lanier LL. NKG2D blockade prevents autoimmune diabetes in NOD mice. Immunity. 2004 Jun; 20(6):757-67.
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      149. Mócsai A, Humphrey MB, Van Ziffle JA, Hu Y, Burghardt A, Spusta SC, Majumdar S, Lanier LL, Lowell CA, Nakamura MC. The immunomodulatory adapter proteins DAP12 and Fc receptor gamma-chain (FcRgamma) regulate development of functional osteoclasts through the Syk tyrosine kinase. Proc Natl Acad Sci U S A. 2004 Apr 20; 101(16):6158-63.
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      150. Tahara-Hanaoka S, Shibuya K, Onoda Y, Zhang H, Yamazaki S, Miyamoto A, Honda S, Lanier LL, Shibuya A. Functional characterization of DNAM-1 (CD226) interaction with its ligands PVR (CD155) and nectin-2 (PRR-2/CD112). Int Immunol. 2004 Apr; 16(4):533-8.
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      151. Arase H, Lanier LL. Specific recognition of virus-infected cells by paired NK receptors. Rev Med Virol. 2004 Mar-Apr; 14(2):83-93.
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      152. Shiratori I, Ogasawara K, Saito T, Lanier LL, Arase H. Activation of natural killer cells and dendritic cells upon recognition of a novel CD99-like ligand by paired immunoglobulin-like type 2 receptor. J Exp Med. 2004 Feb 16; 199(4):525-33.
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      153. Hamerman JA, Ogasawara K, Lanier LL. Cutting edge: Toll-like receptor signaling in macrophages induces ligands for the NKG2D receptor. J Immunol. 2004 Feb 15; 172(4):2001-5.
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      154. Humphrey MB, Ogasawara K, Yao W, Spusta SC, Daws MR, Lane NE, Lanier LL, Nakamura MC. The signaling adapter protein DAP12 regulates multinucleation during osteoclast development. J Bone Miner Res. 2004 Feb; 19(2):224-34.
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      155. Lanier LL. NKG2D. J Biol Regul Homeost Agents. 2003 Oct-Dec; 17(4):338-40.
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      157. Westgaard IH, Dissen E, Torgersen KM, Lazetic S, Lanier LL, Phillips JH, Fossum S. The lectin-like receptor KLRE1 inhibits natural killer cell cytotoxicity. J Exp Med. 2003 Jun 2; 197(11):1551-61.
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      159. Lodoen M, Ogasawara K, Hamerman JA, Arase H, Houchins JP, Mocarski ES, Lanier LL. NKG2D-mediated natural killer cell protection against cytomegalovirus is impaired by viral gp40 modulation of retinoic acid early inducible 1 gene molecules. J Exp Med. 2003 May 19; 197(10):1245-53.
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      161. Cerwenka A, Lanier LL. NKG2D ligands: unconventional MHC class I-like molecules exploited by viruses and cancer. Tissue Antigens. 2003 May; 61(5):335-43.
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      164. Cooper MD, Lanier LL, Conley ME, Puck JM. Immunodeficiency disorders. Hematology Am Soc Hematol Educ Program. 2003; 314-30.
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      165. Michaëlsson J, Teixeira de Matos C, Achour A, Lanier LL, Kärre K, Söderström K. A signal peptide derived from hsp60 binds HLA-E and interferes with CD94/NKG2A recognition. J Exp Med. 2002 Dec 2; 196(11):1403-14.
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      168. Naper C, Hayashi S, Kveberg L, Niemi EC, Lanier LL, Vaage JT, Ryan JC. Ly-49s3 is a promiscuous activating rat NK cell receptor for nonclassical MHC class I-encoded target ligands. J Immunol. 2002 Jul 1; 169(1):22-30.
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      171. Masuda H, Saeki Y, Nomura M, Shida K, Matsumoto M, Ui M, Lanier LL, Seya T. High levels of RAE-1 isoforms on mouse tumor cell lines assessed by anti-"pan" RAE-1 antibody confer tumor susceptibility to NK cells. Biochem Biophys Res Commun. 2002 Jan 11; 290(1):140-5.
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      175. Smith WL, Collins J, Lanier L, Rao VM. Initiative of the Council of Academic Societies. Redefining scholarship in academic radiology. Acad Radiol. 2001 Sep; 8(9):919-21.
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      184. Steinle A, Li P, Morris DL, Groh V, Lanier LL, Strong RK, Spies T. Interactions of human NKG2D with its ligands MICA, MICB, and homologs of the mouse RAE-1 protein family. Immunogenetics. 2001 May-Jun; 53(4):279-87.
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      185. Yim D, Jie HB, Sotiriadis J, Kim YS, Kim KS, Rothschild MF, Lanier LL, Kim YB. Molecular cloning and characterization of pig immunoreceptor DAP10 and NKG2D. Immunogenetics. 2001 Apr; 53(3):243-9.
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      197. Paloneva J, Kestilä M, Wu J, Salminen A, Böhling T, Ruotsalainen V, Hakola P, Bakker AB, Phillips JH, Pekkarinen P, Lanier LL, Timonen T, Peltonen L. Loss-of-function mutations in TYROBP (DAP12) result in a presenile dementia with bone cysts. Nat Genet. 2000 Jul; 25(3):357-61.
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      210. Bakker AB, Baker E, Sutherland GR, Phillips JH, Lanier LL. Myeloid DAP12-associating lectin (MDL)-1 is a cell surface receptor involved in the activation of myeloid cells. Proc Natl Acad Sci U S A. 1999 Aug 17; 96(17):9792-6.
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      211. Bauer S, Groh V, Wu J, Steinle A, Phillips JH, Lanier LL, Spies T. Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA. Science. 1999 Jul 30; 285(5428):727-9.
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      212. Wu J, Song Y, Bakker AB, Bauer S, Spies T, Lanier LL, Phillips JH. An activating immunoreceptor complex formed by NKG2D and DAP10. Science. 1999 Jul 30; 285(5428):730-2.
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      213. Tangye SG, Lazetic S, Woollatt E, Sutherland GR, Lanier LL, Phillips JH. Cutting edge: human 2B4, an activating NK cell receptor, recruits the protein tyrosine phosphatase SHP-2 and the adaptor signaling protein SAP. J Immunol. 1999 Jun 15; 162(12):6981-5.
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      214. Meyaard L, Hurenkamp J, Clevers H, Lanier LL, Phillips JH. Leukocyte-associated Ig-like receptor-1 functions as an inhibitory receptor on cytotoxic T cells. J Immunol. 1999 May 15; 162(10):5800-4.
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      215. Lanier LL. Natural killer cells fertile with receptors for HLA-G? Proc Natl Acad Sci U S A. 1999 May 11; 96(10):5343-5.
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      216. Allan DS, Colonna M, Lanier LL, Churakova TD, Abrams JS, Ellis SA, McMichael AJ, Braud VM. Tetrameric complexes of human histocompatibility leukocyte antigen (HLA)-G bind to peripheral blood myelomonocytic cells. J Exp Med. 1999 Apr 5; 189(7):1149-56.
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      217. Tangye SG, Wu J, Aversa G, de Vries JE, Lanier LL, Phillips JH. Negative regulation of human T cell activation by the receptor-type protein tyrosine phosphatase CD148. J Immunol. 1998 Oct 15; 161(8):3803-7.
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      218. Barton K, Muthusamy N, Fischer C, Ting CN, Walunas TL, Lanier LL, Leiden JM. The Ets-1 transcription factor is required for the development of natural killer cells in mice. Immunity. 1998 Oct; 9(4):555-63.
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      219. Tangye SG, Phillips JH, Lanier LL, de Vries JE, Aversa G. CD148: a receptor-type protein tyrosine phosphatase involved in the regulation of human T cell activation. J Immunol. 1998 Oct 1; 161(7):3249-55.
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      220. Shibuya A, Lanier LL, Phillips JH. Protein kinase C is involved in the regulation of both signaling and adhesion mediated by DNAX accessory molecule-1 receptor. J Immunol. 1998 Aug 15; 161(4):1671-6.
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      221. Smith KM, Wu J, Bakker AB, Phillips JH, Lanier LL. Ly-49D and Ly-49H associate with mouse DAP12 and form activating receptors. J Immunol. 1998 Jul 1; 161(1):7-10.
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      222. Bakker AB, Phillips JH, Figdor CG, Lanier LL. Killer cell inhibitory receptors for MHC class I molecules regulate lysis of melanoma cells mediated by NK cells, gamma delta T cells, and antigen-specific CTL. J Immunol. 1998 Jun 1; 160(11):5239-45.
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      223. Lanier LL, Corliss B, Wu J, Phillips JH. Association of DAP12 with activating CD94/NKG2C NK cell receptors. Immunity. 1998 Jun; 8(6):693-701.
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      224. Leong CC, Chapman TL, Bjorkman PJ, Formankova D, Mocarski ES, Phillips JH, Lanier LL. Modulation of natural killer cell cytotoxicity in human cytomegalovirus infection: the role of endogenous class I major histocompatibility complex and a viral class I homolog. J Exp Med. 1998 May 18; 187(10):1681-7.
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      225. Lanier LL. Follow the leader: NK cell receptors for classical and nonclassical MHC class I. Cell. 1998 Mar 20; 92(6):705-7.
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      226. Braud VM, Allan DS, O'Callaghan CA, Söderström K, D'Andrea A, Ogg GS, Lazetic S, Young NT, Bell JI, Phillips JH, Lanier LL, McMichael AJ. HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C. Nature. 1998 Feb 19; 391(6669):795-9.
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      227. Lanier LL, Corliss BC, Wu J, Leong C, Phillips JH. Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cells. Nature. 1998 Feb 12; 391(6668):703-7.
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      228. Lanier LL. Activating and inhibitory NK cell receptors. Adv Exp Med Biol. 1998; 452:13-8.
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      229. D'Andrea A, Lanier LL. Killer cell inhibitory receptor expression by T cells. Curr Top Microbiol Immunol. 1998; 230:25-39.
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      230. Lanier LL. NK cell receptors. Annu Rev Immunol. 1998; 16:359-93.
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      231. Valiante NM, Uhrberg M, Shilling HG, Lienert-Weidenbach K, Arnett KL, D'Andrea A, Phillips JH, Lanier LL, Parham P. Functionally and structurally distinct NK cell receptor repertoires in the peripheral blood of two human donors. Immunity. 1997 Dec; 7(6):739-51.
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      232. Uhrberg M, Valiante NM, Shum BP, Shilling HG, Lienert-Weidenbach K, Corliss B, Tyan D, Lanier LL, Parham P. Human diversity in killer cell inhibitory receptor genes. Immunity. 1997 Dec; 7(6):753-63.
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      233. Söderström K, Corliss B, Lanier LL, Phillips JH. CD94/NKG2 is the predominant inhibitory receptor involved in recognition of HLA-G by decidual and peripheral blood NK cells. J Immunol. 1997 Aug 1; 159(3):1072-5.
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      234. Meyaard L, Adema GJ, Chang C, Woollatt E, Sutherland GR, Lanier LL, Phillips JH. LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes. Immunity. 1997 Aug; 7(2):283-90.
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      235. Jaleco AC, Blom B, Res P, Weijer K, Lanier LL, Phillips JH, Spits H. Fetal liver contains committed NK progenitors, but is not a site for development of CD34+ cells into T cells. J Immunol. 1997 Jul 15; 159(2):694-702.
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      236. Gumperz JE, Barber LD, Valiante NM, Percival L, Phillips JH, Lanier LL, Parham P. Conserved and variable residues within the Bw4 motif of HLA-B make separable contributions to recognition by the NKB1 killer cell-inhibitory receptor. J Immunol. 1997 Jun 1; 158(11):5237-41.
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      237. Houchins JP, Lanier LL, Niemi EC, Phillips JH, Ryan JC. Natural killer cell cytolytic activity is inhibited by NKG2-A and activated by NKG2-C. J Immunol. 1997 Apr 15; 158(8):3603-9.
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      238. Lanier LL. Natural killer cells: from no receptors to too many. Immunity. 1997 Apr; 6(4):371-8.
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      239. Lanier LL. Natural killer cell receptors and MHC class I interactions. Curr Opin Immunol. 1997 Feb; 9(1):126-31.
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      240. Lanier LL, Corliss B, Phillips JH. Arousal and inhibition of human NK cells. Immunol Rev. 1997 Feb; 155:145-54.
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      241. Renedo M, Arce I, Rodríguez A, Carretero M, Lanier LL, López-Botet M, Fernández-Ruiz E. The human natural killer gene complex is located on chromosome 12p12-p13. Immunogenetics. 1997; 46(4):307-11.
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      242. Binstadt BA, Brumbaugh KM, Dick CJ, Scharenberg AM, Williams BL, Colonna M, Lanier LL, Kinet JP, Abraham RT, Leibson PJ. Sequential involvement of Lck and SHP-1 with MHC-recognizing receptors on NK cells inhibits FcR-initiated tyrosine kinase activation. Immunity. 1996 Dec; 5(6):629-38.
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      243. Valiante NM, Phillips JH, Lanier LL, Parham P. Killer cell inhibitory receptor recognition of human leukocyte antigen (HLA) class I blocks formation of a pp36/PLC-gamma signaling complex in human natural killer (NK) cells. J Exp Med. 1996 Dec 1; 184(6):2243-50.
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      244. Lazetic S, Chang C, Houchins JP, Lanier LL, Phillips JH. Human natural killer cell receptors involved in MHC class I recognition are disulfide-linked heterodimers of CD94 and NKG2 subunits. J Immunol. 1996 Dec 1; 157(11):4741-5.
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      245. Gumperz JE, Paterson JC, Litwin V, Valiante N, Lanier LL, Parham P, Little AM. Specificity of two anti-class I HLA monoclonal antibodies that block class I recognition by the NKB1 killer cell inhibitory receptor. Tissue Antigens. 1996 Oct; 48(4 Pt 1):278-84.
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      246. D'Andrea A, Chang C, Phillips JH, Lanier LL. Regulation of T cell lymphokine production by killer cell inhibitory receptor recognition of self HLA class I alleles. J Exp Med. 1996 Aug 1; 184(2):789-94.
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      247. Phillips JH, Chang C, Mattson J, Gumperz JE, Parham P, Lanier LL. CD94 and a novel associated protein (94AP) form a NK cell receptor involved in the recognition of HLA-A, HLA-B, and HLA-C allotypes. Immunity. 1996 Aug; 5(2):163-72.
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      248. Barber LD, Percival L, Valiante NM, Chen L, Lee C, Gumperz JE, Phillips JH, Lanier LL, Bigge JC, Parekh RB, Parham P. The inter-locus recombinant HLA-B*4601 has high selectivity in peptide binding and functions characteristic of HLA-C. J Exp Med. 1996 Aug 1; 184(2):735-40.
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      249. Fry AM, Lanier LL, Weiss A. Phosphotyrosines in the killer cell inhibitory receptor motif of NKB1 are required for negative signaling and for association with protein tyrosine phosphatase 1C. J Exp Med. 1996 Jul 1; 184(1):295-300.
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      250. Shibuya A, Campbell D, Hannum C, Yssel H, Franz-Bacon K, McClanahan T, Kitamura T, Nicholl J, Sutherland GR, Lanier LL, Phillips JH. DNAM-1, a novel adhesion molecule involved in the cytolytic function of T lymphocytes. Immunity. 1996 Jun; 4(6):573-81.
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      251. Warren HS, Kinnear BF, Kastelein RL, Lanier LL. Analysis of the costimulatory role of IL-2 and IL-15 in initiating proliferation of resting (CD56dim) human NK cells. J Immunol. 1996 May 1; 156(9):3254-9.
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      252. Barber LD, Patel TP, Percival L, Gumperz JE, Lanier LL, Phillips JH, Bigge JC, Wormwald MR, Parekh RB, Parham P. Unusual uniformity of the N-linked oligosaccharides of HLA-A, -B, and -C glycoproteins. J Immunol. 1996 May 1; 156(9):3275-84.
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      253. Gumperz JE, Valiante NM, Parham P, Lanier LL, Tyan D. Heterogeneous phenotypes of expression of the NKB1 natural killer cell class I receptor among individuals of different human histocompatibility leukocyte antigens types appear genetically regulated, but not linked to major histocompatibililty complex haplotype. J Exp Med. 1996 Apr 1; 183(4):1817-27.
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      254. Long EO, Colonna M, Lanier LL. Inhibitory MHC class I receptors on NK and T cells: a standard nomenclature. Immunol Today. 1996 Feb; 17(2):100.
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      255. Onishi M, Kinoshita S, Morikawa Y, Shibuya A, Phillips J, Lanier LL, Gorman DM, Nolan GP, Miyajima A, Kitamura T. Applications of retrovirus-mediated expression cloning. Exp Hematol. 1996 Feb; 24(2):324-9.
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      256. Lanier LL, Phillips JH. Inhibitory MHC class I receptors on NK cells and T cells. Immunol Today. 1996 Feb; 17(2):86-91.
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      257. D'Andrea A, Lanier LL. NKB1: a killer cell inhibitory receptor for class I HLA-B allotypes. Chem Immunol. 1996; 64:104-15.
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      258. Lanier LL. The role of natural killer cells in transplantation. Curr Opin Immunol. 1995 Oct; 7(5):626-31.
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      259. D'Andrea A, Chang C, Franz-Bacon K, McClanahan T, Phillips JH, Lanier LL. Molecular cloning of NKB1. A natural killer cell receptor for HLA-B allotypes. J Immunol. 1995 Sep 1; 155(5):2306-10.
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      260. Chang C, Rodríguez A, Carretero M, López-Botet M, Phillips JH, Lanier LL. Molecular characterization of human CD94: a type II membrane glycoprotein related to the C-type lectin superfamily. Eur J Immunol. 1995 Sep; 25(9):2433-7.
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      261. Spits H, Lanier LL, Phillips JH. Development of human T and natural killer cells. Blood. 1995 May 15; 85(10):2654-70.
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      262. Warren HS, Kinnear BF, Phillips JH, Lanier LL. Production of IL-5 by human NK cells and regulation of IL-5 secretion by IL-4, IL-10, and IL-12. J Immunol. 1995 May 15; 154(10):5144-52.
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      263. Fernández-Ruiz E, Somoza C, Sánchez-Madrid F, Lanier LL. CD28/CTLA-4 ligands: the gene encoding CD86 (B70/B7.2) maps to the same region as CD80 (B7/B7.1) gene in human chromosome 3q13-q23. Eur J Immunol. 1995 May; 25(5):1453-6.
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      264. Phillips JH, Gumperz JE, Parham P, Lanier LL. Superantigen-dependent, cell-mediated cytotoxicity inhibited by MHC class I receptors on T lymphocytes. Science. 1995 Apr 21; 268(5209):403-5.
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      265. Lanier LL, Gumperz JE, Parham P, Melero I, López-Botet M, Phillips JH. The NKB1 and HP-3E4 NK cells receptors are structurally distinct glycoproteins and independently recognize polymorphic HLA-B and HLA-C molecules. J Immunol. 1995 Apr 1; 154(7):3320-7.
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      266. Lanier LL, Phillips JH. NK cell recognition of major histocompatibility complex class I molecules. Semin Immunol. 1995 Apr; 7(2):75-82.
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      267. Somoza C, Lanier LL. T-cell costimulation via CD28-CD80/CD86 and CD40-CD40 ligand interactions. Res Immunol. 1995 Mar-Apr; 146(3):171-6.
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      268. Gumperz JE, Litwin V, Phillips JH, Lanier LL, Parham P. The Bw4 public epitope of HLA-B molecules confers reactivity with natural killer cell clones that express NKB1, a putative HLA receptor. J Exp Med. 1995 Mar 1; 181(3):1133-44.
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      269. Lanier LL, O'Fallon S, Somoza C, Phillips JH, Linsley PS, Okumura K, Ito D, Azuma M. CD80 (B7) and CD86 (B70) provide similar costimulatory signals for T cell proliferation, cytokine production, and generation of CTL. J Immunol. 1995 Jan 1; 154(1):97-105.
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      270. Azuma M, Lanier LL. The role of CD28 costimulation in the generation of cytotoxic T lymphocytes. Curr Top Microbiol Immunol. 1995; 198:59-74.
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      271. Caux C, Vanbervliet B, Massacrier C, Azuma M, Okumura K, Lanier LL, Banchereau J. B70/B7-2 is identical to CD86 and is the major functional ligand for CD28 expressed on human dendritic cells. J Exp Med. 1994 Nov 1; 180(5):1841-7.
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      272. Cifone MG, De Maria R, Roncaioli P, Rippo MR, Azuma M, Lanier LL, Santoni A, Testi R. Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase. J Exp Med. 1994 Oct 1; 180(4):1547-52.
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      273. Lanier LL, Chang C, Phillips JH. Human NKR-P1A. A disulfide-linked homodimer of the C-type lectin superfamily expressed by a subset of NK and T lymphocytes. J Immunol. 1994 Sep 15; 153(6):2417-28.
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      274. Sánchez MJ, Muench MO, Roncarolo MG, Lanier LL, Phillips JH. Identification of a common T/natural killer cell progenitor in human fetal thymus. J Exp Med. 1994 Aug 1; 180(2):569-76.
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      275. Litwin V, Gumperz J, Parham P, Phillips JH, Lanier LL. NKB1: a natural killer cell receptor involved in the recognition of polymorphic HLA-B molecules. J Exp Med. 1994 Aug 1; 180(2):537-43.
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      276. Murphy EE, Terres G, Macatonia SE, Hsieh CS, Mattson J, Lanier L, Wysocka M, Trinchieri G, Murphy K, O'Garra A. B7 and interleukin 12 cooperate for proliferation and interferon gamma production by mouse T helper clones that are unresponsive to B7 costimulation. J Exp Med. 1994 Jul 1; 180(1):223-31.
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      277. Cayabyab M, Phillips JH, Lanier LL. CD40 preferentially costimulates activation of CD4+ T lymphocytes. J Immunol. 1994 Feb 15; 152(4):1523-31.
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      278. Sánchez MJ, Spits H, Lanier LL, Phillips JH. Human natural killer cell committed thymocytes and their relation to the T cell lineage. J Exp Med. 1993 Dec 1; 178(6):1857-66.
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      279. Azuma M, Ito D, Yagita H, Okumura K, Phillips JH, Lanier LL, Somoza C. B70 antigen is a second ligand for CTLA-4 and CD28. Nature. 1993 Nov 4; 366(6450):76-9.
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      280. Litwin V, Gumperz J, Parham P, Phillips JH, Lanier LL. Specificity of HLA class I antigen recognition by human NK clones: evidence for clonal heterogeneity, protection by self and non-self alleles, and influence of the target cell type. J Exp Med. 1993 Oct 1; 178(4):1321-36.
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      281. Yssel H, Schneider PV, Lanier LL. Interleukin-7 specifically induces the B7/BB1 antigen on human cord blood and peripheral blood T cells and T cell clones. Int Immunol. 1993 Jul; 5(7):753-9.
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      282. Lanier LL. Distribution and function of lymphocyte surface antigens. Molecules costimulating T lymphocyte activation and effector function. Ann N Y Acad Sci. 1993 Mar 20; 677:86-93.
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      283. Azuma M, Cayabyab M, Phillips JH, Lanier LL. Requirements for CD28-dependent T cell-mediated cytotoxicity. J Immunol. 1993 Mar 15; 150(6):2091-101.
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      284. Azuma M, Yssel H, Phillips JH, Spits H, Lanier LL. Functional expression of B7/BB1 on activated T lymphocytes. J Exp Med. 1993 Mar 1; 177(3):845-50.
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      285. Azuma M, Phillips JH, Lanier LL. CD28- T lymphocytes. Antigenic and functional properties. J Immunol. 1993 Feb 15; 150(4):1147-59.
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      286. Lanier LL, Spits H, Phillips JH. The developmental relationship between NK cells and T cells. Immunol Today. 1992 Oct; 13(10):392-5.
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      287. Lanier LL, Chang C, Spits H, Phillips JH. Expression of cytoplasmic CD3 epsilon proteins in activated human adult natural killer (NK) cells and CD3 gamma, delta, epsilon complexes in fetal NK cells. Implications for the relationship of NK and T lymphocytes. J Immunol. 1992 Sep 15; 149(6):1876-80.
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      288. Hori T, Phillips JH, Duncan B, Lanier LL, Spits H. Human fetal liver-derived CD7+CD2lowCD3-CD56- clones that express CD3 gamma, delta, and epsilon and proliferate in response to interleukin-2 (IL-2), IL-3, IL-4, or IL-7: implications for the relationship between T and natural killer cells. Blood. 1992 Sep 1; 80(5):1270-8.
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      289. Azuma M, Cayabyab M, Buck D, Phillips JH, Lanier LL. Involvement of CD28 in MHC-unrestricted cytotoxicity mediated by a human natural killer leukemia cell line. J Immunol. 1992 Aug 15; 149(4):1115-23.
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      290. Phillips JH, Hori T, Nagler A, Bhat N, Spits H, Lanier LL. Ontogeny of human natural killer (NK) cells: fetal NK cells mediate cytolytic function and express cytoplasmic CD3 epsilon,delta proteins. J Exp Med. 1992 Apr 1; 175(4):1055-66.
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      291. Azuma M, Cayabyab M, Buck D, Phillips JH, Lanier LL. CD28 interaction with B7 costimulates primary allogeneic proliferative responses and cytotoxicity mediated by small, resting T lymphocytes. J Exp Med. 1992 Feb 1; 175(2):353-60.
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      292. Lanier LL, Phillips JH. Natural killer cells. Curr Opin Immunol. 1992 Feb; 4(1):38-42.
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      293. Azuma M, Phillips JH, Lanier LL. CD28 co-stimulation of T-cell-mediated cytotoxicity. Int J Cancer Suppl. 1992; 7:33-5.
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      294. Phillips JH, McKinney L, Azuma M, Spits H, Lanier LL. A novel beta 4, alpha 6 integrin-associated epithelial cell antigen involved in natural killer cell and antigen-specific cytotoxic T lymphocyte cytotoxicity. J Exp Med. 1991 Dec 1; 174(6):1571-81.
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      295. Harrison D, Phillips JH, Lanier LL. Involvement of a metalloprotease in spontaneous and phorbol ester-induced release of natural killer cell-associated Fc gamma RIII (CD16-II). J Immunol. 1991 Nov 15; 147(10):3459-65.
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      296. Lanier LL, Chang C, Azuma M, Ruitenberg JJ, Hemperly JJ, Phillips JH. Molecular and functional analysis of human natural killer cell-associated neural cell adhesion molecule (N-CAM/CD56). J Immunol. 1991 Jun 15; 146(12):4421-6.
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      297. Phillips JH, Chang CW, Lanier LL. Platelet-induced expression of Fc gamma RIII (CD16) on human monocytes. Eur J Immunol. 1991 Apr; 21(4):895-9.
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      298. Lanier LL, Yu G, Phillips JH. Analysis of Fc gamma RIII (CD16) membrane expression and association with CD3 zeta and Fc epsilon RI-gamma by site-directed mutation. J Immunol. 1991 Mar 1; 146(5):1571-6.
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      299. Nagler A, Lanier LL, Phillips JH. Constitutive expression of high affinity interleukin 2 receptors on human CD16-natural killer cells in vivo. J Exp Med. 1990 May 1; 171(5):1527-33.
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      300. Lanier LL, Cwirla S, Yu G, Testi R, Phillips JH. Membrane anchoring of a human IgG Fc receptor (CD16) determined by a single amino acid. Science. 1989 Dec 22; 246(4937):1611-3.
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      301. Lanier LL, Yu G, Phillips JH. Co-association of CD3 zeta with a receptor (CD16) for IgG Fc on human natural killer cells. Nature. 1989 Dec 14; 342(6251):803-5.
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      302. Nagler A, Lanier LL, Cwirla S, Phillips JH. Comparative studies of human FcRIII-positive and negative natural killer cells. J Immunol. 1989 Nov 15; 143(10):3183-91.
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      303. Testi R, Phillips JH, Lanier LL. T cell activation via Leu-23 (CD69). J Immunol. 1989 Aug 15; 143(4):1123-8.
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      304. Phillips JH, Takeshita T, Sugamura K, Lanier LL. Activation of natural killer cells via the p75 interleukin 2 receptor. J Exp Med. 1989 Jul 1; 170(1):291-6.
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      305. Clark EA, Lanier LL. Report from Vienna: in search of all surface molecules expressed on human leukocytes. J Clin Immunol. 1989 Jul; 9(4):265-72.
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      306. Lanier LL, Testi R, Bindl J, Phillips JH. Identity of Leu-19 (CD56) leukocyte differentiation antigen and neural cell adhesion molecule. J Exp Med. 1989 Jun 1; 169(6):2233-8.
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      307. Groh V, Porcelli S, Fabbi M, Lanier LL, Picker LJ, Anderson T, Warnke RA, Bhan AK, Strominger JL, Brenner MB. Human lymphocytes bearing T cell receptor gamma/delta are phenotypically diverse and evenly distributed throughout the lymphoid system. J Exp Med. 1989 Apr 1; 169(4):1277-94.
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      308. Lanier LL, Phillips JH, Testi R. Membrane anchoring and spontaneous release of CD16 (FcR III) by natural killer cells and granulocytes. Eur J Immunol. 1989 Apr; 19(4):775-8.
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      309. Testi R, Phillips JH, Lanier LL. Leu 23 induction as an early marker of functional CD3/T cell antigen receptor triggering. Requirement for receptor cross-linking, prolonged elevation of intracellular [Ca++] and stimulation of protein kinase C. J Immunol. 1989 Mar 15; 142(6):1854-60.
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      310. Loh EY, Elliott JF, Cwirla S, Lanier LL, Davis MM. Polymerase chain reaction with single-sided specificity: analysis of T cell receptor delta chain. Science. 1989 Jan 13; 243(4888):217-20.
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      311. Testi R, Lanier LL. Functional expression of CD28 on T cell antigen receptor gamma/delta-bearing T lymphocytes. Eur J Immunol. 1989 Jan; 19(1):185-8.
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      312. Loh EY, Cwirla S, Serafini AT, Phillips JH, Lanier LL. Human T-cell-receptor delta chain: genomic organization, diversity, and expression in populations of cells. Proc Natl Acad Sci U S A. 1988 Dec; 85(24):9714-8.
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      313. Lanier LL, Ruitenberg J, Bolhuis RL, Borst J, Phillips JH, Testi R. Structural and serological heterogeneity of gamma/delta T cell antigen receptor expression in thymus and peripheral blood. Eur J Immunol. 1988 Dec; 18(12):1985-92.
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      314. Lanier LL, Ruitenberg JJ, Phillips JH. Functional and biochemical analysis of CD16 antigen on natural killer cells and granulocytes. J Immunol. 1988 Nov 15; 141(10):3478-85.
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      315. Arnaout MA, Lanier LL, Faller DV. Relative contribution of the leukocyte molecules Mo1, LFA-1, and p150,95 (LeuM5) in adhesion of granulocytes and monocytes to vascular endothelium is tissue- and stimulus-specific. J Cell Physiol. 1988 Nov; 137(2):305-9.
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      316. Testi R, Phillips JH, Lanier LL. Constitutive expression of a phosphorylated activation antigen (Leu 23) by CD3bright human thymocytes. J Immunol. 1988 Oct 15; 141(8):2557-63.
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      317. Nagler A, Lanier LL, Phillips JH. The effects of IL-4 on human natural killer cells. A potent regulator of IL-2 activation and proliferation. J Immunol. 1988 Oct 1; 141(7):2349-51.
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      318. Lanier LL, Phillips JH. Effectors, repertoire and receptors involved in lymphocyte-mediated mhc-unrestricted cytotoxicity. Ann Inst Pasteur Immunol. 1988 Jul-Aug; 139(4):450-6.
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      319. Nagler A, Greenberg PL, Lanier LL, Phillips JH. The effects of recombinant interleukin 2-activated natural killer cells on autologous peripheral blood hematopoietic progenitors. J Exp Med. 1988 Jul 1; 168(1):47-54.
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      320. Lanier LL, Buck DW, Rhodes L, Ding A, Evans E, Barney C, Phillips JH. Interleukin 2 activation of natural killer cells rapidly induces the expression and phosphorylation of the Leu-23 activation antigen. J Exp Med. 1988 May 1; 167(5):1572-85.
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      321. Skettino S, Phillips J, Lanier L, Nagler A, Greenberg P. Selective generation of erythroid burst-promoting activity by recombinant interleukin 2-stimulated human T lymphocytes and natural killer cells. Blood. 1988 Apr; 71(4):907-14.
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      322. Richie ER, McEntire B, Crispe N, Kimura J, Lanier LL, Allison JP. Alpha/beta T-cell antigen receptor gene and protein expression occurs at early stages of thymocyte differentiation. Proc Natl Acad Sci U S A. 1988 Feb; 85(4):1174-8.
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      323. Loh EY, Lanier LL, Turck CW, Littman DR, Davis MM, Chien YH, Weiss A. Identification and sequence of a fourth human T cell antigen receptor chain. Nature. 1987 Dec 10-16; 330(6148):569-72.
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      324. Phillips JH, Gemlo BT, Myers WW, Rayner AA, Lanier LL. In vivo and in vitro activation of natural killer cells in advanced cancer patients undergoing combined recombinant interleukin-2 and LAK cell therapy. J Clin Oncol. 1987 Dec; 5(12):1933-41.
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      325. Weiss A, Dazin PF, Shields R, Fu SM, Lanier LL. Functional competency of T cell antigen receptors in human thymus. J Immunol. 1987 Nov 15; 139(10):3245-50.
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      326. Phillips JH, Weiss A, Gemlo BT, Rayner AA, Lanier LL. Evidence that the T cell antigen receptor may not be involved in cytotoxicity mediated by gamma/delta and alpha/beta thymic cell lines. J Exp Med. 1987 Nov 1; 166(5):1579-84.
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      327. Lanier LL, Serafini AT, Ruitenberg JJ, Cwirla S, Federspiel NA, Phillips JH, Allison JP, Weiss A. The gamma T-cell antigen receptor. J Clin Immunol. 1987 Nov; 7(6):429-40.
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      328. Phillips JH, Lanier LL. Acquisition of non-MHC restricted cytotoxic function by IL 2 activated thymocytes with an "immature" antigenic phenotype. J Immunol. 1987 Aug 1; 139(3):683-7.
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      329. Lanier LL, Le AM, Ding A, Evans EL, Krensky AM, Clayberger C, Phillips JH. Expression of Leu-19 (NKH-1) antigen on IL 2-dependent cytotoxic and non-cytotoxic T cell lines. J Immunol. 1987 Apr 1; 138(7):2019-23.
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      330. Lanier LL, Federspiel NA, Ruitenberg JJ, Phillips JH, Allison JP, Littman D, Weiss A. The T cell antigen receptor complex expressed on normal peripheral blood CD4-, CD8- T lymphocytes. A CD3-associated disulfide-linked gamma chain heterodimer. J Exp Med. 1987 Apr 1; 165(4):1076-94.
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      331. Freimark B, Lanier L, Phillips J, Quertermous T, Fox R. Comparison of T cell receptor gene rearrangements in patients with large granular T cell leukemia and Felty's syndrome. J Immunol. 1987 Mar 15; 138(6):1724-9.
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      332. Nagasawa R, Gross J, Kanagawa O, Townsend K, Lanier LL, Chiller J, Allison JP. Identification of a novel T cell surface disulfide-bonded dimer distinct from the alpha/beta antigen receptor. J Immunol. 1987 Feb 1; 138(3):815-24.
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      333. Allison JP, Lanier LL. Structure, function, and serology of the T-cell antigen receptor complex. Annu Rev Immunol. 1987; 5:503-40.
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      334. Herberman RB, Hiserodt J, Vujanovic N, Balch C, Lotzova E, Bolhuis R, Golub S, Lanier LL, Phillips JH, Riccardi C, Ritz J, Santoni A, Schmidt RE, Uchida A. Lymphokine-activated killer cell activity Characteristics of effector cells and their progenitors in blood and spleen. Immunol Today. 1987; 8(6):178-81.
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      335. Allison JP, Lanier LL. The T-cell antigen receptor gamma gene: rearrangement and cell lineages. Immunol Today. 1987; 8(10):293-6.
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      336. Lanier LL, Cwirla S, Phillips JH. Genomic organization of T cell gamma genes in human peripheral blood natural killer cells. J Immunol. 1986 Dec 1; 137(11):3375-7.
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      337. Lanier LL, Le AM, Cwirla S, Federspiel N, Phillips JH. Antigenic, functional, and molecular genetic studies of human natural killer cells and cytotoxic T lymphocytes not restricted by the major histocompatibility complex. Fed Proc. 1986 Nov; 45(12):2823-8.
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      338. Lanier LL, Weiss A. Presence of Ti (WT31) negative T lymphocytes in normal blood and thymus. Nature. 1986 Nov 20-26; 324(6094):268-70.
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      339. Lanier LL, Phillips JH, Hackett J, Tutt M, Kumar V. Natural killer cells: definition of a cell type rather than a function. J Immunol. 1986 Nov 1; 137(9):2735-9.
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      340. Lanier LL, Allison JP, Phillips JH. Correlation of cell surface antigen expression on human thymocytes by multi-color flow cytometric analysis: implications for differentiation. J Immunol. 1986 Oct 15; 137(8):2501-7.
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      341. Tarkkanen J, Saksela E, Lanier LL. Bacterial activation of human natural killer cells. Characteristics of the activation process and identification of the effector cell. J Immunol. 1986 Oct 15; 137(8):2428-33.
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      342. Lanier LL, Ruitenberg JJ, Allison JP, Weiss A. Distinct epitopes on the T cell antigen receptor of HPB-ALL tumor cells identified by monoclonal antibodies. J Immunol. 1986 Oct 1; 137(7):2286-92.
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      343. Phillips JH, Lanier LL. Dissection of the lymphokine-activated killer phenomenon. Relative contribution of peripheral blood natural killer cells and T lymphocytes to cytolysis. J Exp Med. 1986 Sep 1; 164(3):814-25.
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      344. Lanier LL, Ruitenberg JJ, Phillips JH. Human CD3+ T lymphocytes that express neither CD4 nor CD8 antigens. J Exp Med. 1986 Jul 1; 164(1):339-44.
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      345. Lanier LL, Le AM, Civin CI, Loken MR, Phillips JH. The relationship of CD16 (Leu-11) and Leu-19 (NKH-1) antigen expression on human peripheral blood NK cells and cytotoxic T lymphocytes. J Immunol. 1986 Jun 15; 136(12):4480-6.
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      346. Lanier LL, Phillips JH. Evidence for three types of human cytotoxic lymphocyte. Immunol Today. 1986 May; 7(5):132-4.
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      347. Sriram S, Lanier L. NK cell function in a patient with IgM monoclonal antibody against myelin-associated glycoprotein. Neurology. 1986 Apr; 36(4):566-8.
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      348. Phillips JH, Lanier LL. Lectin-dependent and anti-CD3 induced cytotoxicity are preferentially mediated by peripheral blood cytotoxic T lymphocytes expressing Leu-7 antigen. J Immunol. 1986 Mar 1; 136(5):1579-85.
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      349. Clayberger C, Dyer B, McIntyre B, Koller TD, Hardy B, Parham P, Lanier LL, Krensky AM. Function and cell distribution of KC-1, a novel natural killer cell-associated antigen. J Immunol. 1986 Mar 1; 136(5):1537-41.
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      350. Lanier LL, Phillips JH. Human thymic and peripheral blood non-MHC-restricted cytotoxic lymphocytes. Med Oncol Tumor Pharmacother. 1986; 3(3-4):247-54.
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      351. Lanier LL, Cwirla S, Federspiel N, Phillips JH. Human natural killer cells isolated from peripheral blood do not rearrange T cell antigen receptor beta chain genes. J Exp Med. 1986 Jan 1; 163(1):209-14.
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      352. Lanier LL, Phillips JH. Ontogeny of natural killer cells. Nature. 1986 Jan 23-29; 319(6051):269-70.
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      353. Lanier LL, Kipps TJ, Phillips JH. Functional properties of a unique subset of cytotoxic CD3+ T lymphocytes that express Fc receptors for IgG (CD16/Leu-11 antigen). J Exp Med. 1985 Dec 1; 162(6):2089-106.
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      354. Allison JP, McIntyre BW, Ridge LL, Gross-Pelose J, Lanier LL. Molecular characterization of the murine T cell antigen receptor and associated structures. Fed Proc. 1985 Oct; 44(13):2870-3.
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      355. Lanier L. Lymphocyte surface antigens. Introduction. Fed Proc. 1985 Oct; 44(13):2863-4.
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      356. Strassmann G, Springer TA, Haskill SJ, Miraglia CC, Lanier LL, Adams DO. Antigens associated with the activation of murine mononuclear phagocytes in vivo: differential expression of lymphocyte function-associated antigen in the several stages of development. Cell Immunol. 1985 Aug; 94(1):265-75.
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      357. Ault KA, Lanier LL. Terminology in T gamma lymphoproliferative disease. Blood. 1985 Jul; 66(1):248-9.
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      358. Fox RI, Hugli TE, Lanier LL, Morgan EL, Howell F. Salivary gland lymphocytes in primary Sjogren's syndrome lack lymphocyte subsets defined by Leu-7 and Leu-11 antigens. J Immunol. 1985 Jul; 135(1):207-14.
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      359. Lanier LL, Arnaout MA, Schwarting R, Warner NL, Ross GD. p150/95, Third member of the LFA-1/CR3 polypeptide family identified by anti-Leu M5 monoclonal antibody. Eur J Immunol. 1985 Jul; 15(7):713-8.
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      360. Phillips JH, Lanier LL. A model for the differentiation of human natural killer cells. Studies on the in vitro activation of Leu-11+ granular lymphocytes with a natural killer-sensitive tumor cell, K562. J Exp Med. 1985 Jun 1; 161(6):1464-82.
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      361. Allison JP, Lanier LL. Identification of antigen receptor-associated structures on murine T cells. Nature. 1985 Mar 7-13; 314(6006):107-9.
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      362. Green PL, Lamph WW, Dudley J, Arfsten A, Risser R, Lanier LL, Warner NL, Tung JS, Scheid MP. Phenotypic variation in clonal Abelson virus lymphoma cells. J Immunol. 1985 Feb; 134(2):1268-75.
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      363. Lanier LL, Benike CJ, Phillips JH, Engleman EG. Recombinant interleukin 2 enhanced natural killer cell-mediated cytotoxicity in human lymphocyte subpopulations expressing the Leu 7 and Leu 11 antigens. J Immunol. 1985 Feb; 134(2):794-801.
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      364. Waldor MK, Sriram S, Hardy R, Herzenberg LA, Herzenberg LA, Lanier L, Lim M, Steinman L. Reversal of experimental allergic encephalomyelitis with monoclonal antibody to a T-cell subset marker. Science. 1985 Jan 25; 227(4685):415-7.
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      365. Krensky AM, Lanier LL, Engleman EG. Lymphocyte subsets and surface molecules in man. Clin Immunol Rev. 1985; 4(1):95-138.
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      366. Prince HE, Hirji K, Waldbeser LS, Plaeger-Marshall S, Kleinman S, Lanier LL. Influence of racial background on the distribution of T-cell subsets and Leu 11-positive lymphocytes in healthy blood donors. Diagn Immunol. 1985; 3(1):33-7.
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      367. Allison JP, Ridge L, Lund J, Gross-Pelose J, Lanier L, McIntyre BW. The murine T cell antigen receptor and associated structures. Immunol Rev. 1984 Oct; 81:145-60.
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      368. Chen YX, Evans RL, Pollack MS, Lanier LL, Phillips JH, Rousso C, Warner NL, Brodsky FM. Characterization and expression of the HLA-DC antigens defined by anti-Leu 10. Hum Immunol. 1984 Aug; 10(4):221-35.
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      369. Perussia B, Trinchieri G, Jackson A, Warner NL, Faust J, Rumpold H, Kraft D, Lanier LL. The Fc receptor for IgG on human natural killer cells: phenotypic, functional, and comparative studies with monoclonal antibodies. J Immunol. 1984 Jul; 133(1):180-9.
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      370. Basham T, Smith W, Lanier L, Morhenn V, Merigan T. Regulation of expression of class II major histocompatibility antigens on human peripheral blood monocytes and Langerhans cells by interferon. Hum Immunol. 1984 Jun; 10(2):83-93.
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      371. Phillips JH, Le AM, Lanier LL. Natural killer cells activated in a human mixed lymphocyte response culture identified by expression of Leu-11 and class II histocompatibility antigens. J Exp Med. 1984 Apr 1; 159(4):993-1008.
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      372. Lanier LL, Loken MR. Human lymphocyte subpopulations identified by using three-color immunofluorescence and flow cytometry analysis: correlation of Leu-2, Leu-3, Leu-7, Leu-8, and Leu-11 cell surface antigen expression. J Immunol. 1984 Jan; 132(1):151-6.
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      373. Lanier LL, Phillips JH, Warner NL, Babcock GF. A human natural killer cell-associated antigen defined by monoclonal antibody anti-Leu (NKP-15): functional and two-color flow cytometry analysis. J Leukoc Biol. 1984 Jan; 35(1):11-7.
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      374. Hogarth PM, McKenzie IF, Lanier L, Bailey DW, Taylor BA. Location of Ly-7 on mouse chromosome 12. Immunogenetics. 1984; 19(6):539-43.
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      375. Lanier LL, Le AM, Phillips JH, Warner NL, Babcock GF. Subpopulations of human natural killer cells defined by expression of the Leu-7 (HNK-1) and Leu-11 (NK-15) antigens. J Immunol. 1983 Oct; 131(4):1789-96.
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      376. Lanier LL, Warner NL. Lym 7.3: new murine specificity defining third allele of the Ly 7 locus. Hybridoma. 1983; 2(2):177-85.
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      377. Lanier LL, Engleman EG, Gatenby P, Babcock GF, Warner NL, Herzenberg LA. Correlation of functional properties of human lymphoid cell subsets and surface marker phenotypes using multiparameter analysis and flow cytometry. Immunol Rev. 1983; 74:143-60.
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      378. Lanier LL, Richie ER, Howell AL, Allison JP. Expression of Ly-1 and Ly-2 on a spontaneous AKR B-cell lymphoma. Immunogenetics. 1983; 17(6):655-9.
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      379. Phillips JH, Warner NL, Lanier LL. Correlation of biophysical properties and cell surface antigenic profile of Percoll gradient-separated human natural killer cells. Nat Immun Cell Growth Regul. 1983-1984; 3(2):73-86.
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      380. Lanier LL. Activation of murine B cell lymphomas. I. Influence of lipopolysaccharide. J Immunol. 1982 Sep; 129(3):1130-7.
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      381. Walker EB, Lanier LL, Warner NL. Concomitant induction of the cell surface expression of Ia determinants and accessory cell function by a murine macrophage tumor cell line. J Exp Med. 1982 Feb 1; 155(2):629-34.
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      382. Walker EB, Lanier LL, Warner NL. Characterization and functional properties of tumor cell lines in accessory cell replacement assays. J Immunol. 1982 Feb; 128(2):852-9.
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      383. Lanier LL, Gutman GA, Lewis DE, Griswold ST, Warner NL. Monoclonal antibodies against rat immunoglobulin kappa chains. Hybridoma. 1982; 1(2):125-31.
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      384. Lanier LL, Warner NL. Lym 7.2: monoclonal antibody defining an alloantigen similar or identical to Ly 7.2. Hybridoma. 1982; 1(3):227-41.
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      385. Lanier LL, Arnold LW, Raybourne RB, Russell S, Lynes MA, Warner NL, Haughton G. Transplantable B-cell lymphomas in B10. H-2aH-4bp/Wts mice. Immunogenetics. 1982; 16(4):367-71.
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      386. Lanier LL, Warner NL, Ledbetter JA, Herzenberg LA. Quantitative immunofluorescent analysis of surface phenotypes of murine B cell lymphomas and plasmacytomas with monoclonal antibodies. J Immunol. 1981 Oct; 127(4):1691-7.
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      387. Lanier LL, Warner NL, Ledbetter JA, Herzenberg LA. Expression of Lyt-1 antigen on certain murine B cell lymphomas. J Exp Med. 1981 Apr 1; 153(4):998-1003.
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      388. Lanier LL, Warner NL. Cell cycle related heterogeneity of Ia antigen expression on a murine B lymphoma cell line:analysis by flow cytometry. J Immunol. 1981 Feb; 126(2):626-31.
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      389. Lanier LL, Warner NL. Paraformaldehyde fixation of hematopoietic cells for quantitative flow cytometry (FACS) analysis. J Immunol Methods. 1981; 47(1):25-30.
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      390. Lanier LL, Babcock GF, Raybourne RB, Arnold LW, Warner NL, Haughton G. Mechanism of B cell lymphoma immunotherapy with passive xenogeneic anti-idiotype serum. J Immunol. 1980 Oct; 125(4):1730-6.
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      391. Lanier LL, Babcock GF, Lynes MA, Haughton G. Antigen-induced murine B-cell lymphomas. III. Passive anti-idiotype serum therapy and its combined effect with chemotherapy. J Natl Cancer Inst. 1979 Dec; 63(6):1417-22.
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      392. Lanier LL, Babcock GF, Lynes MA, Haughton G. Early detection of the CH1 murine lymphoma by tumor-associated idiotype in the serum. Int J Cancer. 1979 Jul 15; 24(1):53-9.
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      393. Lanier LL, Haughton G. Tolerance to non-H-2 histocompatibility antigens. Transplantation tolerance to the H-4 and H-7 histocompatibility antigens. Transplantation. 1979 Mar; 27(3):208-11.
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      394. Lynes MA, Lanier LL, Babcock GF, Wettstein PJ, Haughton G. Antigen-induced murine B cell lymphomas. I. Induction and characterization of CH1 and CH2. J Immunol. 1978 Dec; 121(6):2352-7.
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      395. Haughton G, Lanier LL, Babcock GF, Lynes MA. Antigen-induced murine B cell lymphomas. II. Exploitation of the surface idiotype as tumor specific antigen. J Immunol. 1978 Dec; 121(6):2358-62.
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      396. Haughton G, Lanier LL, Babcock GF. The murine kappa light chain shift. Nature. 1978 Sep 14; 275(5676):154-7.
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      397. Lanier LL, Lynes M, Haughton G, Wettstein PJ. Novel type of murine B-cell lymphoma. Nature. 1978 Feb 9; 271(5645):554-5.
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